ant(6) fms-007

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aminoglycoside-6-adenyl transferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to ant(6) fms-007

AMR Rules

Browse AMR rules for ant(6) fms-007

Validation StatusCandidate

Overview

Mechanism: inactivation of streptomycin by modifying it with ATP to form streptomycin-AMP
Validation Method: cloning in E. coli + disk diffusion
Drug Classes: streptomycin
Organisms: Elizabethkingia meningoseptica, Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Characterization and Molecular Mechanism of Aminoglycoside-6-Adenyl Transferase Associated with Aminoglycoside Resistance from Elizabethkingia meningoseptica.

PMID 37638067 · 2023

The study identified the ant(6) FMS-007 gene in Elizabethkingia meningoseptica, which confers resistance to streptomycin by modifying it with ATP to form STR-AMP. Mutations N59H and K204Q in the ant(6) gene were found to reduce resistance.

Gene Information

Gene Name: ant(6) fms-007
Allele: ant(6) FMS-007
Encodes: aminoglycoside-6-adenyl transferase
Source Database: Reslit
Mechanism: inactivation of streptomycin by modifying it with ATP to form streptomycin-AMP
Confers Resistance To: streptomycin
Organisms Tested In: • Elizabethkingia meningoseptica
• Escherichia coli
Validation Method: cloning in E. coli + disk diffusion

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ant(6) fms-007

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ant(6) fms-007

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