Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside O-phosphotransferase APH(2'')-If
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| APH(2'')-If | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 21 | TOBRAMYCIN, KANAMYCIN +8 | Campylobacter coli +6 | China, Europe|EU/EEA|China|Spain|USA|Denmark|Sweden|Belgium|Switzerland|Norway|Netherlands|Slovakia|Germany|Romania|Italy|Cyprus, Denmark, global, North Carolina, South China, South Korea, Europe|North America|United States, Chile, UK, Vietnam, Ecuador | 2013, 2017, 2018, 2020, 2021, 2022, 2023, 2024 | KF652097.1 | AGV79344.1 |
| APH(2"-If | Reslit | 1 | kanamycin, tobramycin +1 | Campylobacter jejuni +1 | - | 2013 | GI:57118025 | - |
| aph(2'' )-If | Reslit | 1 | gentamicin | Campylobacter jejuni +1 | USA | 2015 | KF652098|KF652097|KF652096|KF652095|KF652094 | - |
| aph(2"-If | Reslit | 1 | kanamycin, gentamicin | Campylobacter coli +1 | Europe|North America|United States | 2021 | CP061234|CP061235|CP061236|CP061237|CP061238|CP061239|CP061240|CP061241|CP061242|CP061243|CP061244|BioProject PRJNA292664 | - |
| aph(2''-If) | Reslit | 1 | gentamicin, kanamycin | Campylobacter coli +1 | Germany|Vietnam | 2024 | PRJNA562653|PRJNA595957|PRJNA648048|PRJNA872862|NZ_CP091310.1 | - |
| aph(2'')-If | ResFinder Database | 1 | TOBRAMYCIN, KANAMYCIN +2 | Campylobacter coli, Campylobacter jejuni | - | 2005 | KF652097, AY701528 | - |
Novel Aminoglycoside 2"-Phosphotransferase Identified in a Gram-Negative Pathogen.
A novel aminoglycoside 2"-phosphotransferase, APH(2"-If, was identified in Campylobacter jejuni and shown to confer resistance to several 4,6-disubstituted aminoglycosides.
Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen.
Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen.
Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen.
Novel gentamicin resistance genes in Campylobacter isolated from humans and retail meats in the USA.
Nine variants of gentamicin resistance genes were identified in Campylobacter, including six novel ones: aph(2'')-Ib, Ic, If1, If3, Ih, and aac(6')-Ie/aph(2'')-If2. The aph(2'')-Ig gene was shared between human and retail chicken isolates.
High Prevalence and Predominance of the aph(2")-If Gene Conferring Aminoglycoside Resistance in Campylobacter
The aph(2")-If gene was identified as a major contributor to aminoglycoside resistance in Campylobacter, particularly in C. coli isolates from China. It was shown to confer high-level resistance to gentamicin and kanamycin.
The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2016.
The report highlights high levels of antimicrobial resistance in zoonotic bacteria such as Salmonella and Campylobacter, with specific emphasis on resistance to fluoroquinolones, tetracyclines, and sulfonamides. It also notes the emergence of multidrug-resistant strains and the presence of ESBL-producing and carbapenemase-producing E. coli in poultry and meat.
The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2016.
The report highlights high levels of antimicrobial resistance in zoonotic bacteria such as Salmonella and Campylobacter, with specific emphasis on resistance to fluoroquinolones, tetracyclines, and sulfonamides. It also notes the emergence of multidrug-resistant strains and the presence of ESBL-producing and carbapenemase-producing E. coli in poultry and meat.
Prediction of antimicrobial resistance in clinical Campylobacter jejuni isolates from whole-genome sequencing data.
The study identified seven resistance genes and several mutations associated with antimicrobial resistance in Campylobacter jejuni isolates, demonstrating the effectiveness of whole-genome sequencing in predicting resistance.
Genomic Analysis Reveals the Genetic Determinants Associated With Antibiotic Resistance in the Zoonotic Pathogen Campylobacter spp. Distributed Globally.
The study identified 15 acquired genes associated with resistance to five distinct antibiotic classes in Campylobacter spp., including novel beta-lactamase genes blaOXA-493 and blaOXA-576, and characterized mutations in gyrA, rpsL, and 23S rRNA that confer resistance to fluoroquinolones, streptomycin, and macrolides, respectively.
Antimicrobial resistance and interspecies gene transfer in Campylobacter coli and Campylobacter jejuni isolated from food animals, poultry processing, and retail meat in North Carolina, 2018-2019.
The study identified various AMR genes and mutations in Campylobacter isolates from food animals, poultry processing, and retail meat in North Carolina, highlighting the prevalence of tetracycline, quinolone, and aminoglycoside resistance. Key findings include the detection of tet(O), gyrA(T86I), and multiple aminoglycoside resistance genes such as aad9, aadE-Cc, aph(2')-If, and aph(3')-IIIa.
Antimicrobial resistance and interspecies gene transfer in Campylobacter coli and Campylobacter jejuni isolated from food animals, poultry processing, and retail meat in North Carolina, 2018-2019.
The study identified various AMR genes and mutations in Campylobacter isolates from food animals, poultry processing, and retail meat in North Carolina, highlighting the prevalence of tetracycline, quinolone, and aminoglycoside resistance. Key findings include the detection of tet(O), gyrA(T86I), and multiple aminoglycoside resistance genes such as aad9, aadE-Cc, aph(2')-If, and aph(3')-IIIa.
Highly Prevalent Multidrug-Resistant Campylobacter spp. Isolated From a Yellow-Feathered Broiler Slaughterhouse in South China.
The study identified multiple AMR genes and mutations in Campylobacter spp. isolated from a yellow-feathered broiler slaughterhouse, highlighting high levels of multidrug resistance.
Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection.
Nine Clostridioides difficile strains isolated from Korean patients were analyzed, revealing diverse antibiotic resistance genes including those conferring resistance to erythromycin, clindamycin, glycopeptides, fluoroquinolones, aminoglycosides, and tetracyclines.
Natural Horizontal Gene Transfer of Antimicrobial Resistance Genes in Campylobacter spp. From Turkeys and Swine.
The study identified the horizontal transfer of antimicrobial resistance genes, including blaOXA, aph(2''')-If, aadE-Cc, and tet(O), in Campylobacter spp. from turkeys and swine, demonstrating the potential for resistance gene dissemination between different Campylobacter species and hosts.
Natural Horizontal Gene Transfer of Antimicrobial Resistance Genes in Campylobacter spp. From Turkeys and Swine.
The study identified the horizontal transfer of antimicrobial resistance genes, including blaOXA, aph(2''')-If, aadE-Cc, and tet(O), in Campylobacter spp. from turkeys and swine, demonstrating the potential for resistance gene dissemination between different Campylobacter species and hosts.
Differences in the Propensity of Different Antimicrobial Resistance Determinants to Be Disseminated via Transformation in Campylobacter jejuni and Campylobacter coli.
The study identified that the aminoglycoside phosphotransferase gene aph(2")-If confers resistance to gentamicin and kanamycin, and the tetracycline resistance gene tet(O) confers resistance to tetracycline in Campylobacter jejuni and Campylobacter coli.
Whole-genome sequencing reveals changes in genomic diversity and distinctive repertoires of T3SS and T6SS effector candidates in Chilean clinical Campylobacter strains.
The study identified a high genetic diversity among C. jejuni strains and detected mutations in the gyrA gene associated with fluoroquinolone resistance. No macrolide-resistance determinants were found, but tetracycline resistance genes (tetO) and beta-lactamase genes (blaOXA-61, blaOXA-193, blaOXA-450, blaOXA-605) were prevalent. Aminoglycoside resistance genes (aph(2")-If, aac(6')-Im, ant(6)-Ia) and multidrug efflux pump genes (cmeABC) were also detected in a multi-resistant strain.
Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study).
The study found no significant increase in clinically relevant antimicrobial resistance gene burden in critically ill children treated with SDD-enhanced infection control compared to standard care.
Antimicrobial Resistance of Clostridioides difficile in Children from a Tertiary Pediatric Hospital in Shanghai, China.
The study identifies various antimicrobial resistance genes in Clostridioides difficile isolates from children, including those conferring resistance to aminoglycosides, macrolides, fluoroquinolones, glycopeptides, lincosamides, tetracyclines, and others. Notably, the pCD-METRO plasmid and vanA/B were not detected, indicating alternative resistance mechanisms.
Prevalence, antibiotic resistance, and genomic characterisation of Campylobacter spp. in retail chicken in Hanoi, Vietnam.
The study identified multiple AMR genes and mutations in Campylobacter isolates from retail chicken in Hanoi, Vietnam, including aminoglycoside resistance genes (aadE, aadA9, aph(2'')-If, aac(6')-Ie/aph(2'')-Ia), erythromycin resistance gene ermB, tetracycline resistance gene tet(O), beta-lactam resistance gene blaOXA-193, and a quinolone resistance mutation (T86I) in gyrA.
Identification of knowledge gaps in whole-genome sequence analysis of multi-resistant thermotolerant Campylobacter spp.
The study identified 22 different resistance genes and gene variants, including erm(B), aph(3')-IIIa, aadE, catA, lnu(C), blaOXA, sat4, tet(O), and point mutations in gyrA, 23S rRNA, and rpsL, associated with antimicrobial resistance in thermotolerant Campylobacter spp.
Transmission of dominant strains of Campylobacter jejuni and Campylobacter coli between farms and retail stores in Ecuador: Genetic diversity and antimicrobial resistance.
The study identified 14 resistance genes in Campylobacter jejuni and Campylobacter coli isolates, including genes conferring resistance to tetracycline, beta-lactams, and aminoglycosides. Mutations in gyrA, rplV, 23S rRNA, and rpsL were also associated with resistance to fluoroquinolones, macrolides, and aminoglycosides.
Mosaic structure of a multiple-drug-resistant, conjugative plasmid from Campylobacter jejuni.
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