Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside O-phosphotransferase APH(3')-IIIa
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| APH(3')-IIIa | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 135 | KANAMYCIN, AMIKACIN +14 | Campylobacter jejuni +90 | Europe, Korea, New York|Pennsylvania, Taiwan, Greece, Uganda, Turkey, Poland, Warsaw, Texas, Japan, Malaysia|Austria|U.S.A., Seoul|Cheonan, Iran, Italy, China, Australia, Egypt, Latvia, Northwest Iran, Kenya, wastewater treatment plants|Canada, Eastern Uganda, Alberta, Canada, New Hampshire, USA, India, GA, USA, global, Pacific region|Hawaii, Portugal, South Africa, North Upper Egypt|Egypt, South Korea, Pakistan, China|United States of America|United Kingdom|Canada|Spain|Netherlands|France|Germany|Denmark|Europe|North America, Yunnan, China, Novosibirsk, Russia, Czech Republic, Mississippi State|Mississippi, Canada|China|Iran|Poland|United States|Turkey|South Korea|Hong Kong|India|Germany|France|Italy|Spain|Japan|Brazil|Australia|Russia|Mexico|Egypt|Saudi Arabia|South Africa|New Zealand|Sweden|Norway|Denmark|Finland|Iceland|Switzerland|Austria|Belgium|Netherlands|Luxembourg|Portugal|Greece|Czech Republic|Hungary|Romania|Bulgaria|Serbia|Croatia|Slovenia|Slovakia|Ukraine|Israel|Jordan|Lebanon|Syria|Iraq|Afghanistan|Pakistan|Bangladesh|Myanmar|Vietnam|Thailand|Malaysia|Indonesia|Philippines|Singapore|Brunei|Cambodia|Laos|Mongolia|North Korea|Taiwan|Macau|Macao|Taipei|Shanghai|Beijing|Guangzhou|Shenzhen|Chengdu|Chongqing|Wuhan|Hangzhou|Nanjing|Xi'an|Tianjin|Harbin|Changchun|Shenyang|Dalian|Qingdao|Ningbo|Wenzhou|Xiamen|Fuzhou|Quanzhou|Zhengzhou|Luoyang|Kaifeng|Zhuhai|Shantou|Zhongshan|Huizhou|Meizhou|Shaoguan|Heyuan|Zhanjiang|Yangjiang|Maoming|Zhaoqing|Jiangmen|Yangzhou|Nantong|Suzhou|Wuxi|Changzhou|Zhenjiang|Taizhou|Lishui|Huzhou|Jiaxing|Shaoxing|Haining|Anqing|Hefei|Huangshan|Wuhu|Ma'anshan|Chizhou|Tongling|Anhui|Hubei|Hunan|Guangxi|Yunnan|Guizhou|Sichuan|Shaanxi|Gansu|Qinghai|Tibet|Inner Mongolia|Xinjiang|Ningxia|Henan|Shanxi|Hebei|Shandong|Jiangsu|Zhejiang|Fujian|Guangdong|Hainan|Jiangxi, Europe|United States|Asia, Saudi Arabia, Canada|United Kingdom|Alberta, Bangladesh, Algiers|Algeria, Europe|Asia|North America|South America|Brazil, Spain, Shenzhen, China, Ghana, Germany, Edo, Nigeria, New York State, Malaysia, Guangzhou, China, Global|Guinea|Austria|Vietnam|China|Spain|Canada|Hong Kong|Malaysia|Germany|South Africa|Vancouver|Vienna, Canada, Benin, Northern Germany, Algeria, UK, Germany|Vietnam, Brazil, East China, Ecuador, Türkiye, India|Japan|Europe|North America|global, Europe|Africa|North America|South America|Asia|Oceania, Santa Catarina, Brazil|Brazil, Europe|Italy, Hangzhou, China|China, Thailand, Europe|Norway|Romania | 1983, 2001, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AJ490186.1 | CAD36021.1 |
| aph(3')-IIIa | ResFinder Database | 1 | KANAMYCIN, AMIKACIN, AMIKACIN | Enterococcus faecium, Campylobacter jejuni, Enterococcus faecalis | - | 2001 | AF330699, AJ490186, AB247327 | - |
| aph(3')-III | ResFinder DatabaseReslit | 73 | gentamicin, kanamycin +13 | Staphylococcus pseudintermedius +43 | Switzerland, Spain, Thailand|Israel, France|United States, Taiwan|USA, France, USA, Norway, Argentina, China, United States, Poland, Denmark, Italy, North Carolina, Japan, Spain|Basque Country, Hawai'i|Hawaiʻi Island, Brazil, USA|Belgium|Canada, Europe|Netherlands, Europe, Germany|Colombia|Vietnam|Japan|Nicaragua|United States|Canada|Brazil|Thailand|Lebanon|Poland|France|Italy|Spain|Portugal|Mexico|China|South Korea|India, Bangladesh|South Africa|Nigeria|Pakistan|Ethiopia|USA|UK, Alberta, Africa|Asia|America|Europe|Oceania|global, Chiang Mai province, Northern Thailand|Thailand, Shanxi Province, Europe|Taiwan|USA, Japan|Denmark|Norway|China|United States|Switzerland|India|Netherlands, Thailand|Vietnam, Michigan, USA|Michigan, Algeria, Rio de Janeiro, Kenya, Slovak Republic, Saudi Arabia, Portugal, Thailand, Jordan, Asia|North America, Egypt, Haikou, China, Xinjiang, China, Northeast China, China|Shandong Province, China | 1985, 2008, 2010, 2013, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AM904732|AM904731|AM262968|AM262971|AM262969|AM262972|AM262967|AM262970 | - |
| aph ( 3 ′)- III | Reslit | 1 | aminoglycosides | Acinetobacter baumannii | Germany | 2013 | - | - |
| aph3iiia | Reslit | 1 | streptomycin | Clostridium bolteae +1 | France | 2016 | PRJNA64845|PRJNA64847|PRJNA64849|PRJNA64851|PRJNA64853|PRJNA64857|PRJNA659|PRJNA64861|PRJNA64863|PRJNA64865|PRJNA64867|PRJNA64869 | - |
| aph (3′)-IIIa | Reslit | 1 | kanamycin, neomycin | Escherichia coli +2 | India | 2018 | KX300038–KX300086|KY432753|KU573047–KU573052|KY924468–KY924470 | - |
| aph3-iiia | Reslit | 2 | aminoglycosides, gentamicin | Streptococcus suis | Spain|Canada|Brazil|Thailand, Italy | 2018, 2022 | KY689073|KY574604|KY574603|KY400494|KY400495|KY400496 | - |
| aph(3''-III) | Reslit | 1 | kanamycin | Lactobacillus casei | - | 2018 | - | - |
| aph3-III | Reslit | 4 | kanamycin, gentamicin +1 | Staphylococcus hominis +5 | International Space Station, Hong Kong|China, Bangladesh, Australia | 2019, 2020, 2023, 2024 | PRJNA607750 | - |
| aph3-IIIa | Reslit | 2 | gentamicin, kanamycin +1 | Staphylococcus epidermidis +5 | East London|West London, Europe | 2019, 2025 | PRJEB30498 | - |
| aph(3'-III) | Reslit | 2 | gentamicin, kanamycin | Staphylococcus aureus +1 | India | 2019, 2025 | - | - |
| aph(3”)-IIIa | Reslit | 1 | aminoglycosides | E. faecalis | Pacific region|Hawaii | 2021 | - | - |
| Aph3-III | Reslit | 1 | aminoglycosides | Staphylococcus aureus | - | 2021 | - | - |
| aph(3'-IIIa | Reslit | 1 | aminoglycosides | Escherichia coli | Germany | 2022 | SRR17041395|SRR17041394|SRR17041392|SRR17041391|SRR17041390|SRR17041389|SRR17041388|SRR17041387 | - |
| aph (3’)-III | Reslit | 1 | kanamycin, gentamicin | Enterococcus faecium | Hangzhou, China | 2023 | CP103318.1|CP041258.1|LR536642.1 | - |
| aph3'-IIIa | Reslit | 1 | kanamycin | Campylobacter jejuni | Northeast Ohio | 2023 | - | - |
| aph3’IIIa | Reslit | 1 | kanamycin | Campylobacter jejuni | Northeast Ohio | 2023 | - | - |
| aph3'-III | Reslit | 1 | gentamicin, kanamycin +1 | Enterococcus faecium | Latvia | 2024 | - | - |
| APH (3')-IIIa | Reslit | 1 | aminoglycosides | Campylobacter coli | India|Japan|Europe|North America|global | 2024 | JAQSUZ000000000|JAQQFX000000000|JAQQFW000000000 | - |
| aph (3′)-III | Reslit | 1 | gentamicin | Campylobacter jejuni | Europe | 2025 | - | - |
| APH(3'-IIIa | Reslit | 1 | aminoglycosides | Staphylococcus aureus +1 | - | 1999 | - | - |
Aminoglycoside-streptothricin resistance gene cluster aadE-sat4-aphA-3 disseminated among multiresistant isolates of Enterococcus faecium.
Aminoglycoside-streptothricin resistance gene cluster aadE-sat4-aphA-3 disseminated among multiresistant isolates of Enterococcus faecium.
Aminoglycoside-streptothricin resistance gene cluster aadE-sat4-aphA-3 disseminated among multiresistant isolates of Enterococcus faecium., Pheromone-responsive conjugative vancomycin resistance plasmids in Enterococcus faecalis isolates from humans and chicken feces.
Vancomycin-resistant Enterococcus faecium clone in swine, Europe.
The study identified a vancomycin-resistant Enterococcus faecium clone carrying the vanA gene, which confers resistance to glycopeptides, and the erm(B) gene, which confers resistance to erythromycin. Additionally, two Spanish isolates carried the aph(3')-IIIa gene, which provides resistance to kanamycin and streptomycin.
Pheromone-responsive conjugative vancomycin resistance plasmids in Enterococcus faecalis isolates from humans and chicken feces.
The study identifies vancomycin resistance plasmids pSL1 and pSL2 in Enterococcus faecalis isolates from humans and chicken feces, which carry multiple resistance genes including vanA, ermB, aph(3')-IIIa, ant(6')-Ia, and aac(6')-aph(2').
Pheromone-responsive conjugative vancomycin resistance plasmids in Enterococcus faecalis isolates from humans and chicken feces.
Pheromone-responsive conjugative vancomycin resistance plasmids in Enterococcus faecalis isolates from humans and chicken feces.
High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm.
The study identifies vanA, tet(S), and tet(U) as key genes contributing to vancomycin and tetracycline resistance in VRSA isolates, highlighting the role of plasmid-mediated gene transfer in the emergence of multidrug-resistant Staphylococcus aureus.
Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
The study identified a multidrug-resistant PVL+ CA-MRSA ST59 strain in Taiwan with a novel SCC mec type VII, carrying resistance genes such as tetK, cat, aadE, aph(3')-IIIa, ermB, blaZ, and cadDX.
Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.
The study characterizes new SCCmec elements and mutations in topoisomerase genes associated with fluoroquinolone and methicillin resistance in Staphylococcus pseudintermedius.
Linezolid-resistant Staphylococcus cohnii, Greece.
The study reports the emergence of linezolid-resistant Staphylococcus cohnii subsp. ureolyticus in an ICU in Greece, highlighting the presence of resistance genes mecA, ermA, aac(6')-Ie+aph(2''), and aph(3')-IIIa, along with the G2576T mutation in the 23S rRNA gene associated with linezolid resistance.
Skin lesion caused by ST398 and ST1 MRSA, Spain.
The study identifies multiple antimicrobial resistance genes and mutations in MRSA strains causing a skin lesion in a Spanish patient, including mecA, tetK, tetL, tetM, ermA, ermB, ermC, msrA, aph(2')-acc(6'), ant(4')-Ia, aph(3')-III, and dfrK, along with quinolone resistance mutations in grlA and gyrA.
Aminoglycoside modifying enzymes.
The paper discusses various aminoglycoside modifying enzymes, particularly focusing on AAC(6')-Ib, AAC(6')-Ib-cr, and AAC(6')-Ib 11, which confer resistance to aminoglycosides like amikacin and gentamicin, and in some cases, quinolones.
High prevalence of methicillin resistant Staphylococcus aureus in the surgical units of Mulago hospital in Kampala, Uganda.
The study identified a high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in the surgical units of Mulago hospital in Kampala, Uganda. It also characterized several AMR genes including mecA, blaZ, and aminoglycoside-modifying enzymes such as aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, and ant(4')-Ia.
Studying modification of aminoglycoside antibiotics by resistance-causing enzymes via microarray.
The study characterizes three aminoglycoside resistance-causing enzymes: APH(3')-IIIa, ANT(2'')-Ia, and AAC-(3)-IV, which modify aminoglycoside antibiotics, leading to reduced susceptibility.
Antibiotic resistance genes & susceptibility patterns in staphylococci.
The study identified several antibiotic resistance genes in staphylococcal isolates, including mecA for methicillin resistance, aac(6')/aph(2"), aph(3')-IIIa, and ant(4')-Ia for gentamicin resistance, ermA, ermB, ermC, and msrA for erythromycin resistance, tetK and tetM for tetracycline resistance, and blaZ for penicillin resistance.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
Novel pseudo-staphylococcal cassette chromosome mec element (ψSCCmec57395) in methicillin-resistant Staphylococcus pseudintermedius CC45.
The study identifies a novel pseudo-staphylococcal cassette chromosome mec element (ψSCCmec57395) in methicillin-resistant Staphylococcus pseudintermedius CC45, along with various AMR genes such as mecA, blaZ, aac(6')-Ie–aph(2')-Ia, aph(3')-III, ant(6)-Ia, sat4, erm(B), tet(M), dfr(G), and cat pC221. Additionally, fluoroquinolone resistance was linked to specific mutations in gyrA and grlA.
Prevalence of antibiotic resistance in multi-drug resistant coagulase-negative staphylococci isolated from invasive infection in very low birth weight neonates in two Polish NICUs.
The study identified multiple antibiotic resistance genes in coagulase-negative staphylococci (CNS) isolated from very low birth weight neonates, including mecA, ermC, msrA, aac(6')/aph(2''), and aph(3')-IIIa, which conferred resistance to methicillin, erythromycin, clindamycin, gentamicin, and amikacin.
Molecular analysis of vanA outbreak of Enterococcus faecium in two Warsaw hospitals: the importance of mobile genetic elements.
The study identified the vanA gene as the primary determinant of vancomycin and teicoplanin resistance in Enterococcus faecium outbreaks. Additional resistance genes such as erm(B), tet(M), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, and aad6 were also characterized, contributing to multidrug resistance.
Amikacin Resistance in Staphylococcus pseudintermedius Isolated from Dogs.
The study identified aac(6')/aph(2"), aph(3')-IIIa, and ant(4')-Ia as the primary amikacin resistance genes in Staphylococcus pseudintermedius isolates from dogs.
Unraveling antimicrobial resistance genes and phenotype patterns among Enterococcus faecalis isolated from retail chicken products in Japan.
The study identified several antimicrobial resistance genes in Enterococcus faecalis isolated from retail chicken products in Japan, including aac(6')-Ie-aph(2")-Ia, aph(3')-IIIa, ant(6)-Ia, tet(L), tet(M), tet(O), and erm(B). These genes were associated with resistance to various antibiotics such as kanamycin, gentamicin, streptomycin, dihydrostreptomycin, oxytetracycline, and erythromycin.
Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis.
The study identifies several AMR genes, including aac(6')-aph(2")-Ia, vanA, vanB, tetM, ermB, aph(3')-IIIa, and sat4, which are associated with resistance to aminoglycosides, glycopeptides, tetracyclines, macrolides, lincosamides, streptogramin B, and streptothricin in Enterococcus faecium and Enterococcus faecalis.
Detection of antibiotic resistance in probiotics of dietary supplements.
The study detected antibiotic resistance in probiotic bacteria from dietary supplements, including resistance to streptomycin, gentamycin, aztreonam, and ciprofloxacin. Intrinsic resistance genes such as aac(6')-aph(2"), ant(6), aph(3')-IIIa, and blaZ were identified as potential contributors to the observed resistance profiles.
Antimicrobial susceptibility and pathogenic genes of Staphylococcus aureus isolated from the oral cavity of patients with periodontitis.
The study identified the blaZ, aph(3')-IIIa, and tem genes as responsible for penicillin, gentamicin, and ampicillin resistance in Staphylococcus aureus isolates from periodontitis patients.
Demography and Intercontinental Spread of the USA300 Community-Acquired Methicillin-Resistant Staphylococcus aureus Lineage.
The study characterizes the AMR genes and mutations in the USA300 CA-MRSA lineage, highlighting the presence of multiple resistance determinants including beta-lactam, aminoglycoside, macrolide, and fluoroquinolone resistance genes, as well as specific mutations in gyrA and parC contributing to fluoroquinolone resistance.
Characterisation of Phenotypic and Genotypic Antibiotic Resistance Profile of Enterococci from Cheeses in Turkey.
The study identified several antibiotic resistance genes in enterococci from Turkish cheeses, including ermB, tetM, aph(3')-IIIa, cat, and aac(6')-Ieaph(2")-Ia, which confer resistance to macrolides, lincosamides, streptogramin B, tetracycline, kanamycin, gentamicin, and chloramphenicol.
Identification of source and sink populations for the emergence and global spread of the East-Asia clone of community-associated MRSA.
The study identifies distinct antibiotic resistance gene profiles in Staphylococcus aureus ST59 isolates from the USA and East Asia, with the East Asia clade exhibiting higher resistance to beta-lactams, chloramphenicol, tetracyclines, and macrolides.
Comparative genomics of Clostridium bolteae and Clostridium clostridioforme reveals species-specific genomic properties and numerous putative antibiotic resistance determinants.
The study identified numerous antibiotic resistance genes in Clostridium bolteae and Clostridium clostridioforme, including beta-lactamases, glycopeptide resistance operons, macrolide and lincosamide resistance genes, and efflux pumps. Notably, C. bolteae 90B3 exhibited resistance to linezolid, chloramphenicol, florfenicol, and tiamulin due to the presence of the 23S rRNA methyltransferase gene cfr. Additionally, C. clostridioforme 90A8 possessed a VanB-type operon conferring vancomycin resistance.
Comparative genomics of Clostridium bolteae and Clostridium clostridioforme reveals species-specific genomic properties and numerous putative antibiotic resistance determinants.
The study identified numerous antibiotic resistance genes in Clostridium bolteae and Clostridium clostridioforme, including beta-lactamases, glycopeptide resistance operons, macrolide and lincosamide resistance genes, and efflux pumps. Notably, C. bolteae 90B3 exhibited resistance to linezolid, chloramphenicol, florfenicol, and tiamulin due to the presence of the 23S rRNA methyltransferase gene cfr. Additionally, C. clostridioforme 90A8 possessed a VanB-type operon conferring vancomycin resistance.
Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.).
The study identified various AMR genes and mutations in Enterococcus faecalis isolates from macaque cephalic implants, highlighting the presence of high-level aminoglycoside resistance, tetracycline resistance, and bacitracin resistance. These findings emphasize the complexity of AMR in clinical settings and the need for targeted antimicrobial strategies.
Molecular characterization of vancomycin-resistant Staphylococcus aureus strains isolated from clinical samples: A three year study in Tehran, Iran.
The study identified vancomycin-resistant Staphylococcus aureus (VRSA) strains carrying the vanA gene, along with multiple resistance genes such as mecA, ermA, ermB, ermC, msrA, msrB, tetM, ant(4')-Ia, aac(6')-Ie/aph(2'')-Ia, and aph(3')-IIIa. These strains exhibited high-level resistance to vancomycin and other antibiotics.
Detection of tetracycline resistance genes, aminoglycoside modifying enzymes, and coagulase gene typing of clinical isolates of Staphylococcus aureus in the Southwest of Iran.
The study identified aac(6')-Ie-aph(2"), aph(3')-IIIa, ant(4')-Ia, tetK, and tetM as the primary genes responsible for aminoglycoside and tetracycline resistance in Staphylococcus aureus isolates from the Southwest of Iran.
Characterization of multiple antibiotic resistance of culturable microorganisms and metagenomic analysis of total microbial diversity of marine fish sold in retail shops in Mumbai, India.
The study identified multiple antibiotic resistance genes in marine fish isolates, including blaTEM, Class I integron, tetA, aph(3')-IIIa, ermB, aadA, and sul1, indicating a potential risk of antibiotic resistance transmission to humans through the food chain.
Genomic comparisons of Streptococcus suis serotype 9 strains recovered from diseased pigs in Spain and Canada.
The study identified multiple tetracycline, macrolide, lincosamide, and aminoglycoside resistance genes in Streptococcus suis serotype 9 strains, highlighting the widespread presence of antibiotic resistance mechanisms in these isolates.
Analysis of Aminoglycoside Modifying Enzyme Genes Responsible for High-Level Aminoglycoside Resistance among Enterococcal Isolates.
The study identified aac(6')-Ie-aph(2'')-Ia as the predominant gene responsible for high-level gentamicin resistance, while aph(3')-IIIa was found in 40% of high-level streptomycin-resistant isolates.
Clonal Lineage Diversity, Antibiotic Resistance, and Virulence Determinants Among Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Isolated from Nurses at a Teaching Hospital in Ilam, Iran: Successful Nares Decolonization by Mupirocin.
The study identified several AMR genes in S. aureus isolates from nurses, including ermC, msrA, tetK, aac(6')-Ie/aph(2')-Ia, aph(3')-IIIa, and ant(4')-Ia, which conferred resistance to erythromycin, clindamycin, tetracycline, and gentamicin.
Novel linezolid resistance plasmids in Enterococcus from food animals in the USA.
The study identifies novel linezolid resistance plasmids containing optrA and cfr genes in Enterococcus isolates from food animals in the USA, highlighting the potential for horizontal transfer of resistance genes.
Occurrence and characterization of methicillin-resistant Staphylococcus pseudintermedius in successive parturitions of bitches and their puppies in two kennels in Italy.
The study identified multiple methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains in two Italian kennels, highlighting the presence of various resistance mechanisms including beta-lactam, aminoglycoside, macrolide, tetracycline, and chloramphenicol resistance genes.
Safety and Growth Optimization of Lactic Acid Bacteria Isolated From Feedlot Cattle for Probiotic Formula Design.
The study identified several AMR genes in feedlot lactobacilli, including ermB, tet(S), aadA, ant(6), bla, and aph(3''-III), which confer resistance to erythromycin, tetracycline, streptomycin, kanamycin, and ampicillin. These genes were detected through PCR analysis and correlate with phenotypic resistance in some strains.
The Prevalence of Colistin Resistant Strains and Antibiotic Resistance Gene Profiles in Funan River, China.
The study identified mcr-1 and mcr-3 genes as the primary colistin resistance genes in the Funan River, along with other resistance genes such as sul1, sul2, aac(6')-Ib-cr, bla CTX-M, tetM, ermB, qnrS, and aph(3')-IIIa. These genes were found in various bacterial species, highlighting the presence of multidrug-resistant strains in the river.
Remodeling of pSK1 Family Plasmids and Enhanced Chlorhexidine Tolerance in a Dominant Hospital Lineage of Methicillin-Resistant Staphylococcus aureus.
The study identifies several AMR genes, including aac(6')-aph(2"), aadD, aph(3')-IIIa, dfrA, dfrG, qacA, and qacC, associated with resistance to gentamicin, trimethoprim, and chlorhexidine in ST239 MRSA. The pSK1-like plasmids were found to contribute to enhanced resistance and tolerance through the acquisition of these genes.
Phylogenetic Diversity and Antimicrobial Resistance of Campylobacter coli from Humans and Animals in Japan.
Detection of Aminoglycoside Resistant Bacteria in Sludge Samples From Norwegian Drinking Water Treatment Plants.
The study identified aminoglycoside resistance genes aac(6')-Ib, aph(3')-II, and aph(3')-III in a small percentage of the isolates, indicating that resistance mechanisms in the sludge samples are not predominantly due to these enzymes.
Genetic Diversity Analysis of Methicillin-resistant Staphylococcus aureus Strains Isolated from Intensive Care Unit in Iran.
The study identified various AMR genes in MRSA isolates from Iranian ICUs, including genes conferring resistance to aminoglycosides, macrolides, tetracycline, and mupirocin.
Draft Genome Sequence of an Enterococcus faecalis Strain (24FS) That Was Isolated from Healthy Infant Feces and Exhibits High Antibacterial Activity, Multiple-Antibiotic Resistance, and Multiple Virulence Factors.
The study reports the draft genome sequence of Enterococcus faecalis 24FS, highlighting its multiple-antibiotic resistance traits, including resistance to chloramphenicol, tetracycline, erythromycin, aminoglycosides, fluoroquinolones, trimethoprim, streptothricin, and streptomycin, along with potential virulence factors.
Biofilm Forming Antibiotic Resistant Gram-Positive Pathogens Isolated From Surfaces on the International Space Station.
The study identified several AMR genes including ermC, tetK, aac6-aph2a, aph(2)-ic, aadD, aph3-III, and ermB in Gram-positive pathogens isolated from the International Space Station. These genes conferred resistance to erythromycin, tetracycline, gentamicin, kanamycin, and other antibiotics.
Identification and molecular epidemiology of methicillin resistant Staphylococcus pseudintermedius strains isolated from canine clinical samples in Argentina.
The study identified various AMR genes in methicillin-resistant Staphylococcus pseudintermedius (MRSP) isolates from Argentina, including mecA, blaZ, ermB, dfrG, aph(3')-III, ant(6)-Ia, tetM, and aac(6')-Ie-aph(2')-Ia. Mutations in gyrA (S84L) and grlA (S80I) were associated with ciprofloxacin resistance.
Whole genome sequencing revealed new molecular characteristics in multidrug resistant staphylococci recovered from high frequency touched surfaces in London.
The study identified several AMR genes in multidrug-resistant staphylococci from high-frequency touched surfaces in London, including blaZ, qacA/B, dfrC, norA, ant(4')-Ib, AAC(6')-Ie-APH(2")-Ia, fusB, msrA, ermC, mphC, tetK, mupA, cat, dfrG, lnuA, fusC, aph3-IIIa, sat4A, vgaA, and others. These genes conferred resistance to various antibiotics such as penicillin, fusidic acid, mupirocin, tetracycline, erythromycin, and chloramphenicol.
Campylobacter species prevalence, characterisation of antimicrobial resistance and analysis of whole-genome sequence of isolates from livestock and humans, Latvia, 2008 to 2016.
The study identified quinolone resistance mediated by gyrA Thr-86-Ile mutation, tetracycline resistance via tet(O) gene, aminoglycoside resistance through ant(6)-Ib and APH(3')-IIIa genes, and multidrug resistance via cmeABC efflux pump in Campylobacter isolates from Latvia.
High incidence of virulence determinants, aminoglycoside and vancomycin resistance in enterococci isolated from hospitalized patients in Northwest Iran.
The study identified several aminoglycoside resistance genes (aac(6')-Ie-aph(2")-Ia, ant(3")-III, aph(3')-IIIa, ant(6')-Ia) and the vancomycin resistance gene vanA in enterococci isolated from hospitalized patients in Northwest Iran. These genes were found to confer resistance to gentamicin and vancomycin, highlighting the prevalence of multidrug-resistant enterococci in the region.
International Spread of Multidrug-Resistant Campylobacter coli in Men Who Have Sex With Men in Washington State and Quebec, 2015-2018.
Phenotypic and genotypic characterization of clinical Staphylococcus aureus isolates from Kenya.
The study identified multiple antimicrobial resistance genes and mutations in Kenyan Staphylococcus aureus isolates, including mecA, ant(4')-lb, aph(3')-IIIa, ermA, sat-4, fusA, mphC, msrA, gyrA (S84L), parC (S80F), and rpoB mutations, highlighting the presence of multidrug-resistant strains.
Genotypic diversity of Streptococcus suis and the S. suis -like bacterium Streptococcus ruminantium in ruminants.
The study identified several antibiotic resistance genes in Streptococcus ruminantium isolates, including genes conferring resistance to tetracycline, streptomycin, erythromycin, kanamycin, and chloramphenicol. These genes were located in genomic islands and showed similarities to integrative conjugative elements.
Unexpected relationships between frequency of antimicrobial resistance, disease phenotype and emm type in group A Streptococcus.
The study identifies specific AMR genes such as tet(M), erm(B), mef(A), msr(D), tet(O), erm(A), ant(6)-Ia, aph(3')-III, and erm(T) associated with resistance to tetracycline, erythromycin, clindamycin, and aminoglycosides in group A Streptococcus (GAS) strains. These genes are linked to high-frequency resistance in certain emm types, particularly emm11, emm75, emm77, and emm92, which are overrepresented in invasive GAS infections.
Antibiotic Susceptibility, Virulence Pattern, and Typing of Staphylococcus aureus Strains Isolated From Variety of Infections in India.
The study identified various AMR genes in S. aureus isolates, including mecA, pvl, czrC, qacA/B, aac(6')/aph(2), aph(3'-III), msrA, ermA, ermC, mphC, tetK, tetL, tetM, cat::pC221, cat::pC223, cat::pC194, dfrA, dfrB, and dfrG, which confer resistance to multiple antibiotics such as oxacillin, chloramphenicol, gentamicin, erythromycin, clindamycin, tetracycline, and trimethoprim.
Comparative genomics of multidrug-resistant Enterococcus spp. isolated from wastewater treatment plants.
The study identified several AMR genes in multidrug-resistant Enterococcus spp. isolated from wastewater treatment plants, including vancomycin resistance genes (vanA, vanM, vanG, vanC), macrolide resistance genes (ermB, msrC), tetracycline resistance genes (tetL), aminoglycoside resistance genes (aad(6'), aac(6')-Ie-aph(2")-Ia, ant(9')-Ia, aph(3')-IIIa, SAT-4, ant(6')-Ia), chloramphenicol resistance gene (cat), dihydrofolate reductase genes (dfrE, dfrF, dfrG), and lincosamide resistance genes (InuB, InuG).
In Vitro Pharmacodynamic Analyses Help Guide the Treatment of Multidrug-Resistant Enterococcus faecium and Carbapenem-Resistant Enterobacter cloacae Bacteremia in a Liver Transplant Patient.
The study identifies various AMR genes and mutations in Enterococcus faecium and Enterobacter hormaechei isolates from a liver transplant patient, highlighting their roles in resistance to multiple antibiotics.
Characterization of the First mecA-Positive Multidrug-Resistant Staphylococcus pseudintermedius Isolated from an Argentinian Patient.
The study characterizes the first mecA-positive multidrug-resistant Staphylococcus pseudintermedius isolate from an Argentinean patient, identifying several AMR genes and mutations associated with resistance to multiple antibiotics.
Species and drug susceptibility profiles of staphylococci isolated from healthy children in Eastern Uganda.
The study identified several AMR genes including mecA, vanA, vanB, aac(6')-Ie-aph(2'')-Ia, ant(4')-Ia, and aph(3')-IIIa in staphylococci isolated from healthy children in Eastern Uganda. These genes were associated with resistance to methicillin, vancomycin, and aminoglycosides.
Metagenomic analysis reveals the microbiome and resistome in migratory birds.
The study identifies numerous antibiotic resistance genes (ARGs) in migratory birds, highlighting the presence of mcr-1, beta-lactamases, tetracycline resistance genes, and other resistance mechanisms. These findings suggest that migratory birds could serve as reservoirs and potential vectors for spreading ARGs into the environment.
Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum.
The study identified several AMR genes in Enterococcus spp., including erm(B), tet(M), optrA, dfrE, lsa(A), aac(6')-Ib, eat(A), ant(6)-Ia, aph(3')-IIIa, sat4, tet(L), bcrB, bcrC, dfrF, and dfrG, which confer resistance to various antibiotics such as macrolides, tetracyclines, oxazolidinones, trimethoprim, and aminoglycosides.
Genomic Epidemiology and Evolution of Diverse Lineages of Clinical Campylobacter jejuni Cocirculating in New Hampshire, USA, 2017.
The study identified multiple horizontally acquired resistance genes in Campylobacter jejuni isolates from New Hampshire, including genes conferring resistance to beta-lactams, aminoglycosides, streptothricin, and tetracycline.
Emergence of vanA-Type Vancomycin-Resistant Enterococcus faecium ST 78 Strain with a rep2-Type Plasmid Carrying a Tn1546-Like Element Isolated from a Urinary Tract Infection in China.
The study identifies a vanA-type vancomycin-resistant Enterococcus faecium ST78 strain carrying a rep2-type plasmid with a Tn1546-like element. The strain exhibits resistance to multiple antibiotics, including vancomycin, teicoplanin, and aminoglycosides, due to the presence of the vanA, ant(6)-Ia, aph(3')-III, aac(6')-Ii, and msr(C) genes.
New Determinants of Aminoglycoside Resistance and Their Association with the Class 1 Integron Gene Cassettes in Trueperella pyogenes.
The study identified aadA9 and aadA11 as novel aminoglycoside resistance genes in Trueperella pyogenes, along with strA-strB and aph(3')-IIIa, which were reported for the first time in this species.
Genetic analysis of methicillin-susceptible Staphylococcus aureus clinical isolates: High prevalence of multidrug-resistant ST239 with strong biofilm-production ability.
The study identified high prevalence of multidrug-resistant ST239 isolates with strong biofilm-producing ability. Key AMR genes included mupA, fusC, erm(A), erm(C), ant(4')-Ia, aac(6')-Ie/aph(2''), aph(3')-IIIa, tetM, and tetK.
Multidrug-Resistant Streptococcus agalactiae Strains Found in Human and Fish with High Penicillin and Cefotaxime Non-Susceptibilities.
The study identifies multidrug-resistant Streptococcus agalactiae strains with high penicillin and cefotaxime non-susceptibilities, highlighting the emergence of MDR and PEN-NS GBS in both human and aquatic environments.
Comparison of Molecular Subtyping and Antimicrobial Resistance Detection Methods Used in a Large Multistate Outbreak of Extensively Drug-Resistant Campylobacter jejuni Infections Linked to Pet Store Puppies.
The study identified multiple antimicrobial resistance genes and mutations in Campylobacter jejuni isolates from a large multistate outbreak linked to pet store puppies, including resistance to tetracycline, aminoglycosides, macrolides, fluoroquinolones, and others.
Spectrum of Aminoglycoside Modifying Enzymes in Gram-Negative Bacteria Causing Human Infections.
The study identifies various aminoglycoside modifying enzymes (AMEs) in gram-negative bacteria causing human infections, including aac(6′)-lb, aac(3′)-I, aph(3′)-VI, aac(3′)-II, ant(2′)-I, ant(4′)-IIb, aph(2′)-Ib, aph(2′)-Ic, aph(2′)-Id, aac(6′)-Ie-aph(2′)-Ia, and aph(3′)-IIIa. These AMEs confer resistance to multiple aminoglycosides such as amikacin, gentamicin, tobramycin, and netilmicin.
Antimicrobial Resistance and Virulence-Associated Markers in Campylobacter Strains From Diarrheic and Non-diarrheic Humans in Poland.
The study identified several AMR genes, including blaOXA61, blaOXA184, tet(O), tet(O/32/O), aadE-Cc, and aph(3')-III, which confer resistance to beta-lactams, tetracyclines, and aminoglycosides in Campylobacter isolates. Additionally, mutations in the cmeR gene were linked to increased resistance to erythromycin, fluoroquinolones, and macrolides.
Antimicrobial Resistance Gene Detection and Plasmid Typing Among Multidrug Resistant Enterococci Isolated from Freshwater Environment.
The study identified twelve antimicrobial resistance genes in multidrug-resistant Enterococcus isolates from freshwater, including genes conferring resistance to tetracycline, erythromycin, tylosin, kanamycin, streptomycin, and ciprofloxacin. These genes were detected through PCR and sequencing, highlighting the diversity of resistance mechanisms in environmental Enterococcus.
Benchmarking hybrid assembly approaches for genomic analyses of bacterial pathogens using Illumina and Oxford Nanopore sequencing.
The study compared hybrid assembly approaches for bacterial pathogen genomes and identified AMR genes such as blaZ, msr(A), and tet(K) in Staphylococcus aureus.
Prediction of antimicrobial resistance in clinical Campylobacter jejuni isolates from whole-genome sequencing data.
The study identified seven resistance genes and several mutations associated with antimicrobial resistance in Campylobacter jejuni isolates, demonstrating the effectiveness of whole-genome sequencing in predicting resistance.
Genomic Analysis Reveals the Genetic Determinants Associated With Antibiotic Resistance in the Zoonotic Pathogen Campylobacter spp. Distributed Globally.
The study identified 15 acquired genes associated with resistance to five distinct antibiotic classes in Campylobacter spp., including novel beta-lactamase genes blaOXA-493 and blaOXA-576, and characterized mutations in gyrA, rpsL, and 23S rRNA that confer resistance to fluoroquinolones, streptomycin, and macrolides, respectively.
Genotyping and Antibiotic Resistance Traits in Campylobacter jejuni and coli From Pigs and Wild Boars in Italy.
The study identified various AMR genes and mutations in Campylobacter isolates from pigs and wild boars in Italy, highlighting high levels of resistance to tetracycline, ciprofloxacin, nalidixic acid, and erythromycin. Key findings include the detection of tet(O), cmeA, cmeB, cmeC, cmeR, OXA-61, and aph(3')-III genes, as well as the gyrA T86I mutation and 23S rRNA A2075G mutation.
A Possible Role of Insertion Sequence IS1216V in Dissemination of Multidrug-Resistant Elements MES(PM1) and MES(6272-2) between Enterococcus and ST59 Staphylococcus aureus.
The study identifies the role of insertion sequence IS1216V in the dissemination of multidrug-resistant elements MES(PM1) and MES(6272-2) between Enterococcus and ST59 Staphylococcus aureus, highlighting the contribution of IS1216V in mediating the transfer of resistance genes such as ermB, aph(3')-IIIa, aadE, aacA-aphD, and cat.
Benchmarking Long-Read Assemblers for Genomic Analyses of Bacterial Pathogens Using Oxford Nanopore Sequencing.
The study benchmarks long-read assemblers for genomic analyses of bacterial pathogens using Oxford Nanopore sequencing, highlighting the importance of accurate AMR profiling and identifying specific AMR genes such as aph(3')-III, blaOXA-61, and erm(33).
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
Antimicrobial resistance and interspecies gene transfer in Campylobacter coli and Campylobacter jejuni isolated from food animals, poultry processing, and retail meat in North Carolina, 2018-2019.
The study identified various AMR genes and mutations in Campylobacter isolates from food animals, poultry processing, and retail meat in North Carolina, highlighting the prevalence of tetracycline, quinolone, and aminoglycoside resistance. Key findings include the detection of tet(O), gyrA(T86I), and multiple aminoglycoside resistance genes such as aad9, aadE-Cc, aph(2')-If, and aph(3')-IIIa.
Implanted Port Catheter System Infection Caused by Methicillin-resistant Staphylococcus pseudintermedius ST71-SCCmec type III.
The study reports a case of implanted port catheter system infection caused by methicillin-resistant Staphylococcus pseudintermedius ST71-SCC mec III, identifying several AMR genes and mutations including aac(6')-aph(2''), ant(6')-Ia, aph(3')-III, sat4A, mecA, blaZ, erm(B), dfrG, GyrA Ser84Leu, and GrlA Ser80Ile.
Clonal Diversity and Antimicrobial Resistance of Methicillin-Resistant Staphylococcus pseudintermedius Isolated from Canine Pyoderma.
All 31 MRSP isolates were multidrug-resistant, showing resistance to penicillin, macrolides, lincosamides, aminoglycosides, tetracycline, and trimethoprim-sulfamethoxazole. Key resistance genes identified include blaZ, ermB, msr(A/B), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, ant(4')-Ia, tetM, tetK, and dfrG.
Full pathogen characterisation: species identification including the detection of virulence factors and antibiotic resistance genes via multiplex DNA-assays.
The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.
A platform for detecting cross-resistance in antibacterial drug discovery.
The study presents a cross-resistance platform (CRP) consisting of 28 Staphylococcus aureus strains with defined resistance genotypes, designed to detect cross-resistance between established and novel antibacterial agents. The CRP includes various AMR genes and mutations that confer resistance to multiple antibiotic classes.
Clonal Lineages, Antimicrobial Resistance, and PVL Carriage of Staphylococcus aureus Associated to Skin and Soft-Tissue Infections from Ambulatory Patients in Portugal.
The study identified various AMR genes and mutations in S. aureus isolates from SSTIs in ambulatory patients in Portugal, including blaZ, mecA, erm(A), erm(C), msr(A), mph(C), aadD, aacA-aphD, aph(3')-IIIa, and fusC, along with mutations in grlA, gyrA, and fusA associated with fluoroquinolone and fusidic acid resistance.
Whole genome-based characterisation of antimicrobial resistance and genetic diversity in Campylobacter jejuni and Campylobacter coli from ruminants.
The study identified various AMR genes including aminoglycoside-modifying enzymes, tetracycline resistance genes, and beta-lactamases in Campylobacter jejuni and C. coli isolates from ruminants. Mutations in gyrA and rpsL were linked to quinolone and streptomycin resistance, respectively. The presence of specific genetic determinants correlated with phenotypic resistance.
From the Farms to the Dining Table: The Distribution and Molecular Characteristics of Antibiotic-Resistant Enterococcus spp. in Intensive Pig Farming in South Africa.
The study identified tetracycline, erythromycin, streptomycin, and gentamicin resistance genes in Enterococcus spp. isolated from intensive pig farming in South Africa, highlighting the presence of multidrug-resistant strains and the potential for transmission to humans.
Subclinical Mastitis in Selected Bovine Dairy Herds in North Upper Egypt: Assessment of Prevalence, Causative Bacterial Pathogens, Antimicrobial Resistance and Virulence-Associated Genes.
The study identified several AMR genes in bacterial isolates from subclinical mastitis cases in bovine dairy herds in North Upper Egypt, including mecA, blaZ, icaD, aph(3')-IIIa, vanC-2/3as, hyl, cfb, tetA, sul1, fimH, and tsh. These genes were detected through PCR and are associated with resistance to methicillin, beta-lactams, aminoglycosides, vancomycin, tetracyclines, and sulphonamides.
Genomic Analysis of Enterococcus spp. Isolated From a Wastewater Treatment Plant and Its Associated Waters in Umgungundlovu District, South Africa.
The study identified various antibiotic resistance genes in Enterococcus spp. isolated from a wastewater treatment plant in South Africa, including genes conferring resistance to tetracycline, macrolides, aminoglycosides, and trimethoprim.
Antimicrobial Susceptibility of Lactic Acid Bacteria Strains of Potential Use as Feed Additives - The Basic Safety and Usefulness Criterion.
The study identified several AMR genes in LAB strains, including aph(3")-IIIa, erm(B), lnu(A), msr(C), tet(K), and tet(M), which confer resistance to aminoglycosides, macrolides, lincomycins, and tetracyclines. These findings highlight the potential of LAB as reservoirs of AMR genes.
Whole Genome Analysis of Three Multi-Drug Resistant Listeria innocua and Genomic Insights Into Their Relatedness With Resistant Listeria monocytogenes.
The study identified multiple AMR genes in three multi-drug resistant L. innocua isolates, including tet(M), optrA, fexA, dfrG, lnu(B), lsa(E), ant(6)-Ia, erm(B), aph(3')-IIIa, catA8, lnu(A), msr(D), and mef(A). These genes confer resistance to various antibiotics such as tetracycline, oxazolidinones, fluoroquinolones, trimethoprim, lincomycin, macrolides, aminoglycosides, and chloramphenicol.
Environmental Surveillance and Characterization of Antibiotic Resistant Staphylococcus aureus at Coastal Beaches and Rivers on the Island of Hawai'i.
The study identified various antibiotic resistance genes in Staphylococcus aureus isolates from coastal beaches and rivers on the island of Hawai'i, highlighting the presence of multidrug-resistant strains.
Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection.
Nine Clostridioides difficile strains isolated from Korean patients were analyzed, revealing diverse antibiotic resistance genes including those conferring resistance to erythromycin, clindamycin, glycopeptides, fluoroquinolones, aminoglycosides, and tetracyclines.
Genomic Investigation of Methicillin-Resistant Staphylococcus aureus ST113 Strains Isolated from Tertiary Care Hospitals in Pakistan.
The study identified several AMR genes in MRSA ST113 strains, including aph(3')-IIIa, aad(6), sat-4, tet(K), mupA, and ant(4')-Ib, along with a point mutation in fusA conferring resistance to fusidic acid.
Genomic and pathogenic investigations of Streptococcus suis serotype 7 population derived from a human patient and pigs.
The study identified several AMR genes in Streptococcus suis serotype 7 strains, including tetracycline resistance genes (tet(O), tet(M), tet(W)), macrolide/lincosamide/streptogramin resistance gene (erm(B)), aminoglycoside resistance genes (ant(6)-Ia, aph(3')-IIIa, aac(6')-Ie-aph(2'')-Ia), trimethoprim resistance gene (dfrF), and chloramphenicol resistance gene (cat-TC).
Genetic description of VanD phenotype vanA genotype in vancomycin-resistant Enterococcus faecium isolates from a Bone Marrow Transplantation Unit.
The study characterizes the genetic structure of vancomycin-resistant Enterococcus faecium isolates displaying a VanD phenotype with a vanA genotype, highlighting the presence of various resistance genes and genetic variations within the van transposon.
Distribution and Clonal Diversity of Staphylococcus aureus and Other Staphylococci in Surface Waters: Detection of ST425-t742 and ST130-t843 mecC-Positive MRSA Strains.
The study identified mecC-positive MRSA strains ST425-t742 and ST130-t843 in surface waters, along with various AMR genes such as mecC, blaZ, ermT, msr(A/B), vgaA, tetL, mecA, mph(C), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, dfrA, fusB, and catpC221 in Staphylococcus aureus and coagulase-negative staphylococci.
Prevalence and antimicrobial resistance profiling of Staphylococcus aureus isolated from traditional cheese in Yunnan, China.
The study identified 18 antimicrobial resistance genes in Staphylococcus aureus strain DC.RB_015, including mecA, blaZ, mepA, tet(K), tet(38), arlR, arlS, norA, mgrA, LmrS, APH(3′)-IIIa, aad(6), ErmB, SAT-4, mecR1, GlpT, murA, and bacA, which confer resistance to various antibiotics such as methicillin, beta-lactam, tetracycline, fluoroquinolone, macrolide, aminoglycoside, nucleoside, fosfomycin, and bacitracin.
New Sequence Types and Antimicrobial Drug-Resistant Strains of Streptococcus suis in Diseased Pigs, Italy, 2017-2019.
The study identified several AMR genes in Streptococcus suis isolates from diseased pigs in Italy, including ermb, tet(O), aac6-aph2, ant6-ia, aph3-iiia, spw, tet(40), tet(W), tet(O/W/32/O), tet(W/N/N), erm(47), lnuB, lsaE, and optrA, which confer resistance to various antibiotics such as erythromycin, tetracycline, gentamicin, lincomycin, and linezolid.
Antibiotic Resistance and Pathogenomics of Staphylococci Circulating in Novosibirsk, Russia.
The study identified several AMR genes in Staphylococcus isolates from Novosibirsk, Russia, including mecA, blaZ, aac(6')-Ie-aph(2'')-Ia, ant(4')-Ia, aph(3')-IIIa, ermA, ermC, msrA, norA, dfrC, fosB, and mphC, which confer resistance to beta-lactams, aminoglycosides, macrolides, quinolones, and other antibiotics.
Prevalence of Vancomycin-Resistant Enterococci and Antimicrobial Residues in Wastewater and Surface Water.
The study identified vanA and vanB genes in vancomycin-resistant Enterococcus faecium isolates, along with tet(M) and erm(B) genes associated with tetracycline and macrolide resistance, respectively. Aminoglycoside resistance was mediated by aac(6′)-Ie-aph(2′)-Ia and aph(3′)-IIIa genes.
Emerging Fatal Ib/CC12 Hypervirulent Multiresistant Streptococcus agalactiae in Young Infants With Bloodstream Infection in China.
The study identifies multiple antibiotic resistance genes in Ib/CC12 Streptococcus agalactiae strains, including genes conferring resistance to macrolides, clindamycin, aminoglycosides, tetracycline, and other antibiotics.
Assessing the drug resistance profiles of oral probiotic lozenges.
The study identified several antibiotic resistance genes in probiotic lozenges, including erm(T), rpoB, gyr(A), parC, dfrD, aph(3”)-III, ant(2”)-I, erm(B), mefA, cat-TC, vanX, and vatE, which confer resistance to erythromycin, rifampicin, fluoroquinolones, trimethoprim, kanamycin, gentamicin, chloramphenicol, vancomycin, and quinupristin/dalfopristin.
Whole genome sequence analyses-based assessment of virulence potential and antimicrobial susceptibilities and resistance of Enterococcus faecium strains isolated from commercial swine and cattle probiotic products.
The study identified several antimicrobial resistance (AMR) genes in Enterococcus faecium strains isolated from commercial swine and cattle probiotics, including aac(6')-Ii, aph(3')-III, ant(6)-Ia, tet(L), tet(M), msrC, and cat-(pc194). These genes confer resistance to aminoglycosides, tetracyclines, macrolides, lincosamides, streptogramin B, and phenicols.
Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial.
Early-life broad-spectrum antibiotics alter the infant gut microbiome and resistome, with amoxicillin + cefotaxime having the most significant impact on AMR gene profiles.
River Biofilms Microbiome and Resistome Responses to Wastewater Treatment Plant Effluents Containing Antibiotics.
The study identified various antibiotic resistance genes (ARGs) in river biofilms upstream and downstream of a wastewater treatment plant (WWTP), including qnrA, qnrS, mfsA, ermC, ermX, macB, mefA_10, cat, catB3, aadB, aph(3')-III, AAC(3)-Ib, bacA_1, blaPer-1, blaIMP, blaTEM, blaKPC, blaDHA, cblA, ermC, ermY, ermX, mdtL, cusF, copD, qacA, mecA, dfrF, arnA, sul1, sulA, vat(A), IS6100, ISS1N, Intl1, blaCTX-M, blaIMP, mefA_10, tolC, mdfF, acrA, dfrA27, aac(6')-IIa, vanA, intl3, and TTV. These genes were associated with resistance to various antibiotics such as fluoroquinolones, macrolides, chloramphenicol, aminoglycosides, beta-lactams, polymyxins, sulfonamides, and others. The study also found that the resistome composition varied between upstream and downstream sites, indicating the impact of WWTP effluents on the distribution of ARGs in river biofilms.
Extensive metagenomic analysis of the porcine gut resistome to identify indicators reflecting antimicrobial resistance.
The study identified 1295 open reading frames recognized as antimicrobial resistance protein-coding genes in porcine gut microbiomes, highlighting tetracycline, aminoglycoside, and MLS resistance as predominant. Key ARGs like tet(W/N/W), APH(3')-IIIa, and ErmB were found to be highly prevalent and associated with resistance to specific antibiotics.
Comparing Long-Read Assemblers to Explore the Potential of a Sustainable Low-Cost, Low-Infrastructure Approach to Sequence Antimicrobial Resistant Bacteria With Oxford Nanopore Sequencing.
The study identifies the presence of the bla KPC gene in Klebsiella pneumoniae isolates using long-read sequencing, highlighting its role in carbapenem resistance.
Multidrug-Resistant Methicillin-Resistant Coagulase-Negative Staphylococci in Healthy Poultry Slaughtered for Human Consumption.
The study identified multiple multidrug-resistant methicillin-resistant coagulase-negative staphylococci (MRCoNS) in poultry, carrying genes such as mecA, ermA, ermB, ermC, mphC, aph(3')-IIIa, ant(4')-Ia, str, tetK, tetL, tetM, tetO, cfr, dfrK, dfrD, and cat p194, which confer resistance to various antibiotics.
A One Health Approach Molecular Analysis of Staphylococcus aureus Reveals Distinct Lineages in Isolates from Miranda Donkeys (Equus asinus) and Their Handlers.
The study identified various antimicrobial resistance genes in Staphylococcus aureus and coagulase-negative staphylococci (CoNS) isolates from Miranda donkeys and their handlers, including blaZ, aph(3')-IIIa, tetK, tetL, tetM, lnuA, ermB, ermC, mecA, and optrA. These genes confer resistance to penicillins, aminoglycosides, tetracyclines, lincomycins, macrolides, lincosamides, streptogramin B, methicillin, and linezolid.
Antimicrobial resistance determinants in silage.
The study identified 16 antimicrobial resistance genes (ARGs) in silage samples, highlighting their potential to spread through the food chain and contribute to antimicrobial resistance.
Metagenomic Insights Into the Changes of Antibiotic Resistance and Pathogenicity Factor Pools Upon Thermophilic Composting of Human Excreta.
The study identified a decrease in the abundance of various antibiotic resistance genes (ARGs) during thermophilic composting of human excreta, including genes conferring resistance to aminoglycosides, macrolides, sulfonamides, and tetracyclines.
Prevalence, Antimicrobial Resistance, and Molecular Characterization of Campylobacter Isolated from Broilers and Broiler Meat Raised without Antibiotics.
The study identified several antimicrobial resistance genes in Campylobacter isolates, including gyrA, tet(O), blaOXA-61, blaOXA-184, and aph(3')-IIIa, which confer resistance to fluoroquinolones, tetracycline, beta-lactamases, and aminoglycosides, respectively.
Prevalence, Antimicrobial Resistance, and Molecular Characterization of Campylobacter Isolated from Broilers and Broiler Meat Raised without Antibiotics.
The study identified several antimicrobial resistance genes in Campylobacter isolates, including gyrA, tet(O), blaOXA-61, blaOXA-184, and aph(3')-IIIa, which confer resistance to fluoroquinolones, tetracycline, beta-lactamases, and aminoglycosides, respectively.
The Emergence of a Multidrug-Resistant and Pathogenic ST42 Lineage of Staphylococcus haemolyticus from a Hospital in China.
The study identifies the ST42 lineage of Staphylococcus haemolyticus as a multidrug-resistant and pathogenic clone with a high burden of antibiotic resistance genes (ARGs) and virulence determinants.
Characteristics of Streptococcus agalactiae Colonizing Nonpregnant Adults Support the Opportunistic Nature of Invasive Infections.
The study identified ermA, ermB, and mefE genes associated with macrolide resistance in Streptococcus agalactiae isolates from nonpregnant adults, along with tetM for tetracycline resistance and aph(3')-IIIa and ant(6)-Ia for streptomycin resistance.
Antimicrobial Resistance in Acinetobacter spp. Isolated from Pet Reptiles
The study identified various AMR genes in Acinetobacter spp. isolated from pet reptiles, including tetracycline, sulfonamide, and aminoglycoside resistance genes, highlighting the presence of multidrug-resistant strains in these animals.
Antimicrobial Resistance and Clonal Lineages of Staphylococcus aureus from Cattle, Their Handlers, and Their Surroundings: A Cross-Sectional Study from the One Health Perspective.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from cattle, farm workers, and their environment, highlighting the potential for transmission between hosts and the need for monitoring AMR in One Health contexts.
A review of the emergence of antibiotic resistance in bioaerosols and its monitoring methods.
This review highlights the presence of various antibiotic resistance genes (ARGs) in bioaerosols, emphasizing their role in the spread of antibiotic resistance through horizontal gene transfer. Key ARGs identified include those conferring resistance to beta-lactams, tetracyclines, sulfonamides, quinolones, and macrolides.
Comparative Phenotypic and Genomic Features of Staphylococci from Sonication Fluid of Orthopedic Implant-Associated Infections with Poor Outcome.
The study identified various AMR genes in Staphylococcus isolates from orthopedic implant-associated infections, including mecA, blaZ, aminoglycoside modifying enzymes, and erythromycin resistance genes, highlighting the prevalence of multidrug resistance among these isolates.
Antimicrobial resistance and virulence factors in Staphylococcus aureus and other Gram-positive bacteria causing neonatal sepsis in low-resource settings
The study identifies various antimicrobial resistance genes in Staphylococcus aureus and other Gram-positive bacteria causing neonatal sepsis, including mecA, tet(K), tet(M), tet(L), aadD, aph(3)-III, ermA, ermC, msrA, mphC, and IS256. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in low-resource settings.
Genomic Characterization of Enterococcus hirae From Beef Cattle Feedlots and Associated Environmental Continuum.
The study identified several AMR genes in Enterococcus hirae isolates from beef cattle feedlots, including tetracycline resistance genes (tet(L), tet(M), tet(O), tet(S/M), tet(O/32/O)), macrolide resistance gene erm(B), and aminoglycoside resistance genes (aac(6')-Iid, ant(6)-Ia, aph(3')-III, sat4).
Genomic diversity of genus Limosilactobacillus.
The study identified 18 AMR genes in Limosilactobacillus species, primarily in L. reuteri from animal sources, including tetracycline, aminoglycoside, macrolide-lincosamide-streptogramin, and lincomycin resistance genes.
Molecular Mechanisms of Drug Resistance in Staphylococcus aureus.
The paper discusses the molecular mechanisms of drug resistance in Staphylococcus aureus, focusing on beta-lactam, glycopeptide, oxazolidinone, MLS-B, aminoglycoside, and other resistance mechanisms. Key genes identified include blaZ, mecA, mecC, vanA, cfr, ermA, ermC, aac(6')-Ib, aph(3')-IIIa, and aadD. Mutations in pbp2 and pbp2a were also found to contribute to resistance.
Methicillin Resistant Staphylococci Isolated from Goats and Their Farm Environments in Saudi Arabia Genotypically Linked to Known Human Clinical Isolates: a Pilot Study.
The study identified several AMR genes in methicillin-resistant staphylococci isolates from goats and their farm environments in Saudi Arabia, including mecA, blaZ, norA, lmrS, mepA, mepR, arlR, arlS, tet(38), mecR1, dfrC, fusC, fosB, fexA, tetM, msrA, mphC, fusB, APH(3′)-IIIa, tetK, and dfrG. These genes confer resistance to various antibiotics such as penicillins, fluoroquinolones, aminoglycosides, macrolides, phenicols, diaminopyrimidines, oxazolidinones, tetracyclines, and fosfomycin.
Nasal Staphylococcus aureus and S. pseudintermedius carriage in healthy dogs and cats: a systematic review of their antibiotic resistance, virulence and genetic lineages of zoonotic relevance.
The study identifies various AMR genes such as mecA, blaZ, tet(M), erm(B), aac(6')-aph(2"), aadD, ant(6)-Ia, and sat4 in Staphylococcus aureus and S. pseudintermedius isolates from healthy dogs and cats, indicating widespread antibiotic resistance.
Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents.
The study identifies various AMR genes in Enterococcus faecium, including vanA, vanB, ermB, ermT, ermA, aad(6), aph(3')-IIIa, aac(6')-Ie-aph(2')-Ia, sat-4, tetM, tet(W/N/W), dfrG, dfrF, lnuB, optrA, and lsaE, which are associated with different habitats and geographic locations.
Balancing the Virulence and Antimicrobial Resistance in VISA DAP-R CA-MRSA Superbug.
The study identifies several AMR genes, including ant(6)-Ia, aph(3')-III, blaZ, mecA, ermC, and tetK, which contribute to resistance against aminoglycosides, beta-lactams, macrolides, and tetracyclines in VISA DAP-R CA-MRSA. Additionally, a mutation in mprF (Thr345Ala) is linked to daptomycin and glycopeptide resistance.
Antimicrobial Resistance, Virulence Profiles, and Public Health Significance of Enterococcus faecalis Isolated from Clinical Mastitis of Cattle in Bangladesh.
The study identified tetracycline resistance genes tetK, tetL, and tetM, as well as aminoglycoside resistance genes aacC2, aacC4, and aph(3'')-IIIa, and the vancomycin resistance gene vanB in Enterococcus faecalis isolates from bovine clinical mastitis in Bangladesh.
Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2 Streptococcus suis isolates from healthy pigs.
The study identified 18 AMR genes in non-serotype 2 Streptococcus suis isolates from healthy pigs, including genes conferring resistance to aminoglycosides, macrolides, lincosamides, tetracyclines, oxazolidinones, nucleosides, and phenicols.
First Genome-Based Characterisation and Staphylococcal Enterotoxin Production Ability of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus Strains Isolated from Ready-to-Eat Foods in Algiers (Algeria).
The study identified several AMR genes and mutations in S. aureus strains isolated from ready-to-eat foods in Algeria, including blaZ, ermB, lmrS, tet(L), tet(38), aph(3')-IIIa, ant(6)-I, mecA, and a gyrA mutation (S84L) conferring resistance to various antibiotics.
How Streptococcus suis escapes antibiotic treatments.
The study characterizes various AMR genes and mutations in Streptococcus suis, highlighting resistance to beta-lactams, macrolides, lincosamides, streptogramins, amphenicols, pleuromutilins, tetracyclines, sulfonamides, trimethoprim, and fluoroquinolones.
Concordance between Antimicrobial Resistance Phenotype and Genotype of Staphylococcus pseudintermedius from Healthy Dogs.
The study identified 17 antibiotic resistance genes in Staphylococcus pseudintermedius isolates from healthy dogs, including blaZ, mecA, ermB, tetM, aac(6')-aph(2''), ant(6)-Ia, aph(3')-IIIa, spw, str, and dfrG. It also found mutations in gyrA and parC genes associated with fluoroquinolone resistance, and mutations in rpoB and clpP linked to vancomycin resistance.
Genetic characteristics, antimicrobial resistance, and prevalence of Arcobacter spp. isolated from various sources in Shenzhen, China.
The study identified several AMR genes in Arcobacter spp., including beta-lactamase genes (blaOXA464, blaOXA491), tetracycline resistance genes (tet(L), tet(H), tet(M)), a macrolide resistance gene (ere(A)), and aminoglycoside resistance genes (APH(3')-IIIa, ant(6)-Ia, SAT-4). Additionally, a mutation in the gyrA gene (C254T) was found to confer fluoroquinolone resistance.
Whole-Genome and Plasmid Comparative Analysis of Campylobacter jejuni from Human Patients in Toyama, Japan, from 2015 to 2019.
The study identified tetracycline resistance gene tet(O), aminoglycoside resistance genes ant(6)-Ia and aph(3')-III, and chloramphenicol resistance gene cat in Campylobacter jejuni isolates from Toyama, Japan. Additionally, blaOXA-184 was found in ampicillin-resistant isolates.
Molecular characterization of Arcobacter butzleri isolates from poultry in rural Ghana.
The study identified several antimicrobial resistance genes in Arcobacter butzleri isolates from poultry in Ghana, including blaOXA-464, tetM, ermB, and others, highlighting the presence of multidrug-resistant strains and the potential for horizontal and vertical transmission of resistance genes.
Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteria.
The study identified several acquired and intrinsic antimicrobial resistance genes in lactic acid bacteria and bifidobacteria, including tetW, ANT(6)-Ia, aac(6')-Ie-APH(2'')-Ia, erm(B), erm(49), cat, dfrG, arr-4, and fosXCC. Additionally, mutations in S12, rsmG, Lsa(A), MsrC, and PBP5 were associated with resistance to various antibiotics.
Metagenomic analysis reveals patterns and hosts of antibiotic resistance in different pig farms.
The study identified various antibiotic resistance genes (ARGs) in pig manure samples from different regions of Shanxi, China, highlighting the prevalence of tetracycline, aminoglycoside, macrolide, and phenicol resistance genes. Key ARGs included tet(W), tet(40), tet(Q), erm(B), erm(F), mef(A), aph(3')-III, ant(6)-Ia, cfr(C), floR, blaACI-1, optrA, cat, cfxA4, cfxA5, blaCTX-M-105, blaCTX-M-65, fexB, erm(T), mdf(A), and ole(B).
Antimicrobial resistance in Campylobacter fetus: emergence and genomic evolution.
The study identified several AMR genes and mutations in Campylobacter fetus, including ant(6)-Ib, aph(3')-III, tet(O), tet(44), and cat, which confer resistance to various antibiotics. Mutations in the gyrA gene were also found to contribute to fluoroquinolone resistance.
Genomic Characterization of a Vancomycin-Resistant Strain of Enterococcus faecium Harboring a rep2 Plasmid.
The study identified a vancomycin-resistant Enterococcus faecium strain (SJ2) harboring the vanA gene on a rep2 plasmid. The strain exhibited resistance to multiple antibiotics, including vancomycin, and contained several other antimicrobial resistance genes.
Genomic insight into Campylobacter jejuni isolated from commercial turkey flocks in Germany using whole-genome sequencing analysis.
The study identified multiple beta-lactam resistance genes (blaOXA variants), tetracycline resistance gene tet(O), aminoglycoside resistance genes (aadE, aph(3')-IIIa, sat4), and a fluoroquinolone resistance mutation (gyrA T86I) in Campylobacter jejuni isolates from German turkey flocks.
A multicentre study reveals dysbiosis in the microbial co-infection and antimicrobial resistance gene profile in the nasopharynx of COVID-19 patients.
The study identified a variety of antimicrobial resistance genes in the nasopharynx of COVID-19 patients, including beta-lactamases, macrolide-lincosamide-streptogramin resistance genes, tetracycline resistance genes, and others. These genes were found to be prevalent in both symptomatic and asymptomatic patients, highlighting the importance of monitoring antimicrobial resistance in the context of the pandemic.
Prevalence, multiple antibiotic resistance and virulence profile of methicillin-resistant Staphylococcus aureus (MRSA) in retail poultry meat from Edo, Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant Staphylococcus aureus (MRSA) isolated from retail poultry meat in Edo, Nigeria, highlighting the prevalence of multidrug-resistant MRSA and the presence of virulence factors that pose a public health concern.
Genomic Analysis of Vancomycin-Resistant Staphylococcus aureus Isolates from the 3rd Case Identified in the United States Reveals Chromosomal Integration of the vanA Locus.
The study identifies the chromosomal integration of the vanA locus in vancomycin-resistant Staphylococcus aureus (VRSA) isolates, highlighting the role of plasmid pWC79 in multidrug resistance and the genetic mechanisms behind the emergence of VRSA.
Enterococcal Linear Plasmids Adapt to Enterococcus faecium and Spread within Multidrug-Resistant Clades.
The study identifies pELF1-like plasmids in Enterococcus faecium that carry multiple antimicrobial resistance genes, including vancomycin resistance determinants, aminoglycoside resistance genes, macrolide resistance genes, tetracycline resistance genes, and oxazolidinone resistance genes. These plasmids are associated with multidrug-resistant clades and demonstrate high stability and self-transmissibility.
Complete Genome Sequence and Analysis of a ST573 Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus SauR3 Clinical Isolate from Terengganu, Malaysia.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant S. aureus isolate SauR3, including blaZ, mecA, norA, norC, sdrM, ermC, lmrS, msrA, mphC, aph(3′)-IIIa, aadE, aac(6′)Ie-aph(2″)Ia, fosB, and SAT-4, contributing to resistance against various antibiotics.
Genomic comparison of two Streptococcus suis serotype 1 strains recovered from porcine and human disease cases.
The study identified tetracycline resistance gene tet(O), macrolide-lincosamide-streptogramin resistance gene erm(B), and aminoglycoside resistance genes ant(6)-Ia and aph(3')-III in two Streptococcus suis serotype 1 strains.
Whole genome characterization of thermophilic Campylobacter species isolated from dairy manure in small specialty crop farms of Northeast Ohio.
The study identified various antimicrobial resistance genes in Campylobacter isolates from dairy manure, including blaOXA-193, aadE-Cc, gyrA_T86I, tetO, aph3'-IIIa, rpsL_K88R, and 50S_L22_A103V, indicating multidrug resistance in these isolates.
Whole genome characterization of thermophilic Campylobacter species isolated from dairy manure in small specialty crop farms of Northeast Ohio.
The study identified various antimicrobial resistance genes in Campylobacter isolates from dairy manure, including blaOXA-193, aadE-Cc, gyrA_T86I, tetO, aph3'-IIIa, rpsL_K88R, and 50S_L22_A103V, indicating multidrug resistance in these isolates.
Overcoming biological barriers to improve treatment of a Staphylococcus aureus wound infection.
The study identifies aminoglycoside-modifying enzymes aac(6')-Ib, aph(3')-IIIa, and ant(4')-la as responsible for gentamicin resistance in Staphylococcus aureus and Enterococcus faecalis. Palmitoleic acid enhances gentamicin efficacy against resistant strains by increasing uptake.
Identification and Characterization of a Vancomycin Intermediate-Resistant Staphylococcus haemolyticus Isolated from Guangzhou, China.
The study identifies vancomycin intermediate-resistant Staphylococcus haemolyticus SH-1 carrying multiple drug resistance genes and novel mutations in WalK gene associated with vancomycin resistance.
Antibiotic Susceptibility Profiling of Human Pathogenic Staphylococcus aureus Strains Using Whole Genome Sequencing and Genome-Scale Annotation Approaches.
The study identified several AMR genes in multidrug-resistant S. aureus strains, including blaZ, mecA, mecC, norA, norC, MgrA, tet(45), APH(3′)-IIIa, ermC, AAC(6′)-APH(2″), and fusC. These genes confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, tetracyclines, aminoglycosides, macrolides, lincosamides, streptogramin B, and fusidic acid.
Antimicrobial resistance in bacteria isolated from peridomestic Rattus species: A scoping literature review.
This scoping review identifies various antimicrobial resistance (AMR) genes in bacteria isolated from peridomestic Rattus species, including beta-lactamases (bla TEM, bla CTX-M, bla SHV, bla VIM, bla IMP, bla NDM-1), aminoglycoside resistance genes (strA, strB, aadA, aphA), sulfonamide resistance genes (sul1, sul2, sul3), tetracycline resistance genes (tetA, tetB, tet34), trimethoprim resistance genes (dfrA1, dfrA17, dfr14), quinolone resistance genes (qnrB1), and others.
The gut microbiome and resistome of conventionally vs. pasture-raised pigs.
The study found that conventionally raised pigs had a significantly higher abundance of antimicrobial resistance genes (ARGs) compared to pasture-raised pigs, particularly for aminoglycosides, beta-lactams, macrolides-lincosamides-streptogramin B, and tetracyclines. Several ARGs, including aph(3')-IIIa, erm(B), erm(X), tet(Q), tet(36), tet(W/N/W), blaOXA-193, and cfxA2, were identified as being more prevalent in the gut microbiome of conventionally raised pigs.
Occurrence, Antibiotic Susceptibility, Biofilm Formation and Molecular Characterization of Staphylococcus aureus Isolated from Raw Shrimp in China.
The study identified multiple antibiotic resistance genes in Staphylococcus aureus isolates from raw shrimp in China, including mecA, mecR1, blaZ, aph(3')-IIIa, aad(6), ANT(4')-Ib, tet(K), mph(C), lnu(A), ermB, ermC, dfrC, dfrG, fosB, SAT-4, rpoB, msr(A), mepA, mepR, norA, mgrA, tet(38), sav1866, arlR, and arlS, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, macrolides, lincosamides, streptogramins, trimethoprim, fosfomycin, and others.
Pangenomic analyses of antibiotic-resistant Campylobacter jejuni reveal unique lineage distributions and epidemiological associations.
The study identifies various antibiotic resistance genes including bla(OXA-193), bla(OXA-460), tet(O), and aph(3')-III in Campylobacter jejuni strains, highlighting the prevalence of multidrug resistance and the significance of specific lineages in Michigan.
Genomic and Antimicrobial Surveillance of Campylobacter Population in Italian Poultry.
The study identified several AMR genes and mutations in Campylobacter isolates from Italian poultry, highlighting the emergence of multidrug-resistant strains and the prevalence of specific resistance mechanisms such as the T86I mutation in gyrA and the tet(O) gene.
Genetic characterization of MDR genomic elements carrying two aac(6')-aph(2") genes in feline-derived clinical Enterococcus faecalis isolate.
The study identified a multidrug-resistant E. faecalis isolate (ESC1) carrying a novel composite transposon with two aac(6')-aph(2") genes, along with several other resistance genes on plasmids, contributing to resistance against multiple antibiotics.
Whole-Genome Sequencing-Based Screening of MRSA in Patients and Healthcare Workers in Public Hospitals in Benin.
The study identified multiple AMR genes and mutations in MRSA isolates from Benin, including mecA, aac(6')-Ie/aph(2")-Ia, aph(3')-IIIa, blaI, blaR1, blaZ, mecI, mecR1, fosB, erm(C), mph(C), msr(A), qacC, dfrG, and dfrS1, along with mutations in glpT, murA, gyrA, and parC associated with resistance to various antibiotics.
Clostridioides difficile from Fecally Contaminated Environmental Sources: Resistance and Genetic Relatedness from a Molecular Epidemiological Perspective.
The study identified multiple AMR genes in C. difficile isolates from environmental sources, including gyrA, gyrB, blaCDD-1, blaCDD-2, tet(M), tet(40), aph(3')-IIIa, ant(6)-la, sat-4, and ermB, which confer resistance to fluoroquinolones, beta-lactams, tetracyclines, aminoglycosides, and MLS B antibiotics.
Antimicrobial resistance and whole genome sequencing of novel sequence types of Enterococcus faecalis, Enterococcus faecium, and Enterococcus durans isolated from livestock.
The study identifies several antimicrobial resistance genes in Enterococcus species isolated from livestock in South Africa, highlighting the presence of multidrug-resistant strains and emphasizing the need for genomic surveillance to monitor the spread of antimicrobial resistance in food chain animals.
Antimicrobial Resistance Genes in Staphylococcus Species Isolated from Diabetic Foot Ulcers and Healthy Skin
The study identified various antimicrobial resistance genes in Staphylococcus species isolated from diabetic foot ulcers and healthy skin, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, macrolides, tetracyclines, fusidic acid, trimethoprim-sulfamethoxazole, fosfomycin, kanamycin, neomycin, and quaternary ammonium compounds.
Antimicrobial Resistance Genes in Staphylococcus Species Isolated from Diabetic Foot Ulcers and Healthy Skin
The study identified various antimicrobial resistance genes in Staphylococcus species isolated from diabetic foot ulcers and healthy skin, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, macrolides, tetracyclines, fusidic acid, trimethoprim-sulfamethoxazole, fosfomycin, kanamycin, neomycin, and quaternary ammonium compounds.
Investigation of antimicrobial susceptibility and genetic diversity among Staphylococcus pseudintermedius isolated from dogs in Rio de Janeiro.
The study identified 21 resistance determinants in MRSP and MSSP strains of Staphylococcus pseudintermedius, including genes such as blaZ, sdrM, norA, fosB, ykkcd, sepA, aac(6')-aph(2''), dfrG, aph(3')-III, ant(6)-Ia, sat4, erm(B), aad(6), tet(M), cat(pC221), qacG, tet(K), and qacJ, which confer resistance to various antimicrobials.
Metagenomic assembly is the main bottleneck in the identification of mobile genetic elements.
The study evaluated the performance of tools for identifying mobile genetic elements (MGEs) and antimicrobial resistance genes (ARGs) in metagenomic data. It found that metagenomic assembly is the main bottleneck in accurately identifying MGEs and ARGs, with moderate precision and sensitivity for plasmids, phages, IS elements, and ARGs.
Canine Staphylococcaceae circulating in a Kenyan animal shelter.
The study identified various AMR genes in Staphylococcaceae strains isolated from dogs in a Kenyan animal shelter, including tetracycline, beta-lactam, and aminoglycoside resistance genes.
Effects of Neolamarckia cadamba leaves extract on microbial community and antibiotic resistance genes in cecal contents and feces of broilers challenged with lipopolysaccharides.
The study found that Neolamarckia cadamba leaves extract (NCLE) reduced the abundance of antibiotic resistance genes (ARGs) in cecal contents of lipopolysaccharide (LPS)-induced broilers by maintaining microbial balance.
Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study).
The study found no significant increase in clinically relevant antimicrobial resistance gene burden in critically ill children treated with SDD-enhanced infection control compared to standard care.
Genomic resistant determinants of multidrug-resistant Campylobacter spp. isolates in Peru.
Comparative genomic analysis of antibiotic resistance and virulence genes in Staphylococcus aureus isolates from patients and retail meat.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from both patients and retail meat, including blaZ, fosB-Saur, tet38, mphC, msrA, sat4, mecA, aph(3')-IIIa, and fusC. These genes were associated with resistance to various antibiotics such as penicillin, tetracycline, macrolides, and fusidic acid.
Characterization of the resistome and predominant genetic lineages of Gram-positive bacteria causing keratitis.
The study characterizes the resistome of Gram-positive bacteria causing keratitis, identifying several AMR genes and mutations associated with resistance to antibiotics such as macrolides, aminoglycosides, tetracyclines, and fluoroquinolones. Key findings include the prevalence of ermA, ermB, ermC, mphC, msrA, msrD, mecA, ant(9)-Ia, ant(4′)-Ib, aac(6′)-aph(2″), aph(3′)-III, fosB, tetK, tetM, dfrG, dfrC, and dfrE genes, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Antimicrobial Resistance of Clostridioides difficile in Children from a Tertiary Pediatric Hospital in Shanghai, China.
The study identifies various antimicrobial resistance genes in Clostridioides difficile isolates from children, including those conferring resistance to aminoglycosides, macrolides, fluoroquinolones, glycopeptides, lincosamides, tetracyclines, and others. Notably, the pCD-METRO plasmid and vanA/B were not detected, indicating alternative resistance mechanisms.
Identification of knowledge gaps in whole-genome sequence analysis of multi-resistant thermotolerant Campylobacter spp.
The study identified 22 different resistance genes and gene variants, including erm(B), aph(3')-IIIa, aadE, catA, lnu(C), blaOXA, sat4, tet(O), and point mutations in gyrA, 23S rRNA, and rpsL, associated with antimicrobial resistance in thermotolerant Campylobacter spp.
Gut diversity and the resistome as biomarkers of febrile neutropenia outcome in paediatric oncology patients undergoing hematopoietic stem cell transplantation.
The study identifies several antibiotic-resistance genes associated with febrile neutropenia in pediatric oncology patients undergoing hematopoietic stem cell transplantation, including msr(C), dfrG, erm(T), VanHAX, aac(6')-Ib, aph(3')-III, ant(6)-Ia, and aac(6')-Ii.
Genomic insights into the diversity, virulence, and antimicrobial resistance of group B Streptococcus clinical isolates from Saudi Arabia.
The study identified several AMR genes including erm(B), erm(A), lsa(C), mef(A), tet(M), tet(O), aac(6')-aph(2''), ant(6)-Ia, aph(3')-III, and aadE in GBS isolates from Saudi Arabia, highlighting the prevalence of resistance to macrolides, lincosamides, tetracycline, and aminoglycosides.
Defining the phylogenetics and resistome of the major Clostridioides difficile ribotypes circulating in Australia.
The study identifies AMR genes such as ermB, tetM, aac(6')-Ib, sat4A, ant6-Ia, and aph3-III in Clostridioides difficile strains, particularly in RT014/020. Mutations in gyrA and gyrB contribute to fluoroquinolone resistance. AMR is uncommon, with limited evidence of clonal transmission.
Proteomic assay for rapid characterisation of Staphylococcus aureus antimicrobial resistance mechanisms directly from blood cultures.
The study presents a rapid proteomic method using LC-MS/MS to detect and quantify key antimicrobial resistance effectors in Staphylococcus aureus directly from blood cultures, achieving high agreement rates for PBP2a, PBP2c, APH(3')-III, ANT(4')-I, and AAC(6')-APH(2'').
Methicillin-resistant Staphylococcus aureus and coagulase-negative Staphylococcus produce antimicrobial substances against members of the skin microbiota in children with atopic dermatitis.
The study identified two bacteriocin gene clusters, aureocin 4181 in MRSA 23ad and epidermicin NI01 in S. epidermidis 84ad, which are involved in the production of antimicrobial substances that inhibit the growth of other staphylococcal species.
Genetic Complexity of CC5 Staphylococcus aureus Isolates Associated with Sternal Bursitis in Chickens: Antimicrobial Resistance, Virulence, Plasmids, and Biofilm Formation.
The study identified multiple antimicrobial resistance genes in S. aureus isolates from sternal bursitis in chickens, including aph(3')-IIIa, tetK, tet38, ermC, parC, and fosB, which confer resistance to aminoglycosides, tetracyclines, macrolides, fluoroquinolones, and fosfomycin.
Evaluation of Antimicrobial Resistancein Clinical Isolates of Enterococcus spp. Obtained from Hospital Patients in Latvia.
The study identifies several AMR genes and mutations in Enterococcus isolates, including vanB for vancomycin resistance, lsaA, lsaE, lnuB for lincosamide resistance, tetM and tetL for tetracycline resistance, aac6'-Ii, aac6'-aph2'', aph3'-III, and ant6-Ia for aminoglycoside resistance, msrC, ermB, and ermT for macrolide resistance, and mutations in gyrA, parC, pbp5, and 23S rRNA for fluoroquinolone, penicillin, and linezolid resistance.
Five centuries of genome evolution and multi-host adaptation of Campylobacter jejuni in Brazil.
The study identifies beta-lactam resistance genes blaOXA-193 and blaOXA-184, as well as the multidrug efflux pump operon cmeABCR in Campylobacter jejuni isolates from Brazil. Mutations in gyrA and rrn genes are associated with quinolone and macrolide resistance.
Emergence of Staphylococcus argenteus in pediatrics: Molecular insights from a hospital in East China.
The study identified six antibiotic-resistance genes in the S. argenteus strain 22WJ8192, including blaZ, blaI_of_Z, blaR1, aph(3')-IIIa, tet(38), and fosB-Saur, which conferred resistance to penicillin, amikacin, tetracycline, and fosfomycin. These genes were found to be more prevalent in human-origin strains compared to nonhuman-origin strains.
Transmission of dominant strains of Campylobacter jejuni and Campylobacter coli between farms and retail stores in Ecuador: Genetic diversity and antimicrobial resistance.
The study identified 14 resistance genes in Campylobacter jejuni and Campylobacter coli isolates, including genes conferring resistance to tetracycline, beta-lactams, and aminoglycosides. Mutations in gyrA, rplV, 23S rRNA, and rpsL were also associated with resistance to fluoroquinolones, macrolides, and aminoglycosides.
A single amplified genome catalog reveals the dynamics of mobilome and resistome in the human microbiome.
The study identifies numerous AMR genes in oral and fecal SAGs, highlighting the presence of resistance mechanisms such as efflux pumps, quinolone resistance proteins, dihydrofolate reductases, erythromycin ribosome methyltransferases, and aminoglycoside phosphotransferases.
Safety assessment of enterocin-producing Enterococcus strains isolated from sheep and goat colostrum.
The study identified antibiotic resistance genes aph(3')-IIIa, tetM, and tetL in certain Enterococcus strains, indicating resistance to gentamicin and tetracycline. However, most strains showed susceptibility to clinically significant antibiotics.
In vivo transfer of genetic information between gram-positive and gram-negative bacteria.
Campylobacter coli of porcine origin exhibits an open pan-genome within a single clonal complex: insights from comparative genomic analysis.
The study identified several AMR genes in C. coli isolates of porcine origin, including tetO, blaOXA-193, and APH (3')-IIIa, which confer resistance to tetracyclines, beta-lactams, and aminoglycosides, respectively. Additionally, a mutation in the gyrA gene (T86I) was found to confer fluoroquinolone resistance.
Campylobacter coli of porcine origin exhibits an open pan-genome within a single clonal complex: insights from comparative genomic analysis.
The study identified several AMR genes in C. coli isolates of porcine origin, including tetO, blaOXA-193, and APH (3')-IIIa, which confer resistance to tetracyclines, beta-lactams, and aminoglycosides, respectively. Additionally, a mutation in the gyrA gene (T86I) was found to confer fluoroquinolone resistance.
Diversity of Campylobacter spp. circulating in a rhesus macaque (Macaca mulatta) breeding colony using culture and molecular methods.
The study identified several AMR genes and mutations in Campylobacter spp. isolated from a rhesus macaque breeding colony, including beta-lactamase genes blaOXA-193 and blaOXA-489, aminoglycoside resistance genes aadE-Cc and aph(3')-III, tetracycline resistance gene tet(O), and mutations in 23S rRNA and gyrA that confer resistance to macrolides and quinolones respectively.
Cytotoxic Activity of Vancomycin-Resistant Enterococci Isolated from Hospitalised Patients.
The study identified aac(6')-Ie-aph(2'')-Ia and aph(3')-IIIa genes contributing to aminoglycoside resistance, along with vanA gene causing vancomycin resistance in VRE isolates. Linezolid and tigecycline resistance were also observed.
Data-Driven Approaches in Antimicrobial Resistance: Machine Learning Solutions.
This study uses unsupervised machine learning to identify patterns in AMR genes, linking gene length and resistance class to resistance mechanisms. Key AMR genes identified include sul1, sul2, cat, blaTEM, vanA, aac(6')-Ib, aph(3')-IIIa, tet(M), and tet(O).
Methicillin-Resistant S. aureus Carrying the PVL and Toxic Shock Syndrome Toxin in Healthy Dogs in Algeria.
The study identified methicillin-resistant S. aureus (MRSA) in healthy dogs in Algeria, with isolates carrying the mecA gene and other resistance genes such as blaZ, ant(6)-Ia, aph(3')-III, erm(C), and tet(K). Some isolates also harbored the PVL and tst genes encoding virulence factors.
Microbial spectrum and resistance of odontogenic abscesses - microbiological analysis using next generation sequencing.
The study identified multiple AMR genes in odontogenic abscesses using NGS, including genes conferring resistance to tetracyclines, macrolides, lincosamides, aminoglycosides, chloramphenicol, sulfonamides, penicillins, and others. Notably, Fusobacterium showed resistance to clindamycin.
The healthy human gut can take it all: vancomycin-variable, linezolid-resistant strains and specific bacteriocin-species interplay in Enterococcus spp.
The study identifies linezolid resistance genes optrA and poxtA in Enterococcus faecium and Enterococcus thailandicus isolates, along with a vancomycin-variable E. faecium strain. It also reveals the increasing prevalence of E. lactis in the healthy human gut and the complex interplay of bacteriocin gene profiles among Enterococcus species.
The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials.
The study identified several AMR genes in Staphylococcus hominis, including erm(C), tetK, acc(6')-Ie aph(2''), aph(3')-IIIa, ant(4')-Ia, msr(B), mph(C), lnu(A), and vga, which confer resistance to various antibiotics such as macrolides, lincosamides, streptogramins, tetracyclines, and aminoglycosides. The majority of the strains exhibited multidrug resistance.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Evaluation of the resistome and gut microbiome composition of hospitalized patients in a health unit of southern Brazil coming from a high animal husbandry production region.
The study identified a high prevalence of aminoglycoside and tetracycline resistance genes, including aph(3')-IIIa, ermB, mcr-1, qnrB19, and tetQ, in hospitalized patients from a high animal husbandry region. Unique resistance genes and mutations, such as dfrF and gyrB, were noted at discharge.
Comparison of Staphylococcus pettenkoferi Isolated from Human Clinical Cases and Cat Carriers Regarding Antibiotic Susceptibility and Biofilm Production.
The study identified several AMR genes in Staphylococcus pettenkoferi isolates from human and feline sources, including blaZ, mecA, ermA, tet(L), vanA, aph3-IIIa, ter(M), mupA, and fusB, which confer resistance to various antibiotics such as penicillins, methicillin, erythromycin, tetracyclines, vancomycin, gentamicin, mupirocin, and fusidic acid.
Genetic compatibility and ecological connectivity drive the dissemination of antibiotic resistance genes.
The study identifies and characterizes various antibiotic resistance genes (ARGs) involved in horizontal gene transfer, highlighting the role of genetic compatibility and ecological connectivity in the dissemination of these genes.
Next-generation diagnostics of bloodstream infections enabled by rapid whole-genome sequencing of bacterial cells purified from blood cultures.
The study presents a rapid whole-genome sequencing workflow (LC-WGS) for diagnosing bloodstream infections, demonstrating accurate identification of bacterial pathogens and detection of clinically relevant resistance markers within 4.2 hours. The workflow successfully identified various AMR genes, including bla CTX-M-15, bla DHA-1, bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-23, armA, mecA, vanRSHAXYZ, aac(6')-Ie/aph(2'')-Ia, aph(3')-IIIa, aac(6')-I, sul1, and dfrA17.
High-Risk VREfm Clones and Resistance Determinants in a Thai Hospital.
The study identified the vanA gene as the primary determinant of vancomycin resistance in all 29 VREfm isolates. Additional resistance genes such as aac(6')-Ii, ant(6')-Ia, erm(B), msr(C), tet(L), tet(M), aph(3')-III, aph(2'')-Ia, and inu(B) were also characterized, contributing to resistance against a variety of antibiotics.
Molecular characterization and antimicrobial-resistance gene profile of Staphylococcus aureus strains isolated from ovine mastitis in Jordan.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from ovine mastitis in Jordan, including blaZ, aph(3')-III, ant(4')-Ia, str, and mecA. These genes conferred resistance to penicillin G, kanamycin, streptomycin, and methicillin.
Phylogenomic associations among methicillin-resistant Staphylococcus aureus isolates derived from pets, dairies, and humans.
The study identified several AMR genes in methicillin-resistant Staphylococcus aureus (MRSA) isolates from pets, dairies, and humans, including mecA, tet(M), tet(K), erm(C), erm(A), mph(C), msr(A), blaR1, blaZ, blaI_of_Z, blaPC1, vga(A), fosB-Saur, sat4, bleO, ant(9)-Ia, aph(2'')-Ih, aph(3')-IIIa, and ant(4')-Ia. These genes confer resistance to various antibiotics such as methicillin, tetracycline, erythromycin, macrolides, lincomycin, fosfomycin, streptothricin, bleomycin, spectinomycin, amikacin, gentamicin, kanamycin, tobramycin, and others.
AmrProfiler: A Comprehensive Tool for Antimicrobial Resistance Gene Detection and Analysis
AmrProfiler identifies a wide range of AMR genes and mutations across multiple bacterial species, demonstrating high accuracy and broader species coverage compared to existing tools.
Assessment of Factors Contributing to Infection Severity and High Levels of Drug Resistance in Clinical Enterococcus Isolates.
The study identified several AMR genes, including vanA, aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, ant(6')-Ia, and ant(3'')-Ia, which confer resistance to vancomycin, gentamicin, and streptomycin in Enterococcus isolates. High levels of multidrug resistance and biofilm formation were also observed.
Phenotypic and whole genome-based characterization of antibiotic resistance of Campylobacter jejuni isolates from chicken livers.
The study identified several AMR genes and mutations in Campylobacter jejuni isolates from chicken livers, including blaOXA-185 and blaOXA-61 for beta-lactam resistance, tet(O) for tetracycline resistance, and CmeABC efflux pump for multidrug resistance. Additionally, a point mutation T86I in the gyrA gene was linked to ciprofloxacin resistance.
The characteristics of methicillin-resistant Staphylococcus aureus co-infection in COVID-19 pneumonia.
The study identified several antimicrobial resistance genes in MRSA isolates from patients with COVID-19 pneumonia and MRSA pneumonia without COVID-19, including aac(6')-aph(2''), aph(2'')-Ia, aph(3')-III, aadD, ermA, ermB, ermC, tetM, tetK, mupA, and tst. No significant differences in antimicrobial resistance genes were observed between the two groups.
Rabbit carcasses as important vectors of multidrug-resistant Enterococcus faecalis, but not E. faecium: prevalence and molecular characterization from a study in Poland.
The study identified multiple AMR genes in Enterococcus faecalis isolates from rabbit carcasses, including aac(6')-Ie-aph(2")-Ia, ant(6)-Ia, aph(3')-IIIa, ermB, tetM, and tetL, which were consistent with the observed phenotypic resistance patterns.
Genomic analysis and antimicrobial resistance in human- and poultry-derived Campylobacter jejuni isolates from Hangzhou, China.
The study identified several AMR genes and mutations in Campylobacter jejuni isolates, including gyrA mutations (T86I and T86V) associated with quinolone resistance, tet(O) for tetracycline resistance, and various beta-lactamase genes (blaOXA-61, blaOXA-193, blaOXA-450, blaOXA-451, blaOXA-452, blaOXA-453, blaOXA-489) linked to beta-lactam resistance. Additionally, aminoglycoside resistance genes APH(3')-IIIa and ant(6)-Ia were found in some isolates.
Genomic insights into the diversity, antimicrobial resistance and zoonotic potential of Campylobacter fetus across diverse hosts and geographies.
The study identified five AMR genes in Campylobacter fetus, including tet(O), tet(44), ant(6)-Ib, aph(3′)-III, and lnu(C), which confer resistance to tetracyclines, streptomycin, amikacin, and lincomycin. These genes were detected in human and animal isolates from various geographic regions.
Study of lug Operon, SCCmec Elements, Antimicrobial Resistance, MGEs, and STs of Staphylococcus lugdunensis Clinical Isolates Through Whole-Genome Sequencing.
The study identified several AMR genes, including mecA, blaZ, erm(A), aac(6')-aph(2"), aph(3')-III, ant(9)-Ia, and dfrG, in S. lugdunensis isolates, which conferred resistance to various antibiotics such as penicillins, oxacillin, erythromycin, clindamycin, aminoglycosides, and trimethoprim-sulfamethoxazole.
Prevalence and antimicrobial resistance of methicillin-resistant and methicillin-susceptible Staphylococcus in small- to medium-scale and large-scale dairy farms in Thailand.
The study identified several AMR genes and mutations in Staphylococcus isolates from small- to medium-scale and large-scale dairy farms in Thailand, highlighting differences in resistance profiles between farm types.
Genomic and phenotypic characterization of methicillin-resistant Staphylococcus aureus ST965: an emerging hospital-adapted clone with enhanced invasiveness.
The study identifies multiple AMR genes in ST965-MRSA, including blaI-blaR-blaZ, erm(B), erm(C), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, mepA, mepR, cadD, cadC, and the plasmid pYF965, which contribute to multidrug resistance and hospital adaptation.
Antimicrobial resistance pattern in Campylobacter strains isolated from both no-antibiotics-ever (NAE) and conventional broiler complexes: Genotypic and phenotypic characterization.
The study identified several AMR genes in Campylobacter strains from NAE and conventional broiler complexes, including bla OXA-61, bla OXA-184, tet (O), tet (O/32/O), and aph (3′)-III. These genes conferred resistance to various antibiotics such as tetracycline, cefoxitin, aztreonam, and gentamicin.
Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China.
The study identified the optrA gene as the primary mechanism of linezolid resistance in Enterococcus species from cancer patients in China, along with other resistance genes such as tet(M), erm(A), and erm(B).
Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance.
The study presents a framework to predict no-effect concentrations for antibiotic resistance selection in the environment by integrating minimum inhibitory concentration (MIC) data with resistance-related fitness costs. It identifies various AMR genes and their resistance profiles through competition experiments.
Isolation and Molecular Characterization of Three Staphylococcus pseudintermedius Strains from Dogs and Humans in Egypt.
Three Staphylococcus pseudintermedius isolates from dogs and humans in Egypt were characterized. The isolates showed resistance to various antibiotics, including penicillin, tetracycline, aminoglycosides, chloramphenicol, fusidic acid, macrolides, streptothricin, and trimethoprim. None of the isolates carried the mecA gene, which is associated with methicillin resistance.
Molecular epidemiology and antibiotic resistance of group B Streptococcus in pregnant women and neonates from Haikou, China: implications for vaccine development and antimicrobial stewardship.
The study identified high rates of tetracycline (89.1%) and clindamycin (55.1%) resistance in GBS strains from Haikou, China. Key resistance genes included mreA, ermB, tetM, catQ, cat(pC194), ant(6)-Ia, aph(3')-III, and aac(6')-aph(2'').
Antimicrobial resistance reservoirs in salmon and broiler processing environments, sidestreams, and waste discharges.
The study identified several high-risk AMR genes in salmon and broiler processing environments, including multidrug resistance genes TolC and mdtE, tetracycline genes tet(L) and tet(M), aminoglycoside genes APH(3′)-IIIa and APH(6)-Id, and beta-lactam genes mecA and mecR1. Additionally, the study found quinolone-resistant Escherichia coli (QREC) in waste discharges from two broiler processing plants and multidrug resistant (MDR) E. coli in one plant.
Antimicrobial resistance and virulence gene patterns of Staphylococcus aureus in infectious mastitis: implications for inflammatory myopathies of the lactating breast.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from lactating patients with infectious mastitis, including aac(6')/aph(2"), blaZ, mecA, aph(3')-III, and qacA/B. These genes were associated with resistance to various antibiotics such as penicillin G, erythromycin, clindamycin, gentamicin, levofloxacin, ciprofloxacin, and tetracycline.
Molecular epidemiology and geographical variation of methicillin-resistant Staphylococcus aureus: a multicentre study across Xinjiang, China.
The study identified several AMR genes in MRSA isolates from Xinjiang, China, including blaZ, ermB, aph(3')-III, aac(6')-aph(2''), ermC, tetM, and tetK, which confer resistance to various antibiotics such as penicillin, oxacillin, erythromycin, clindamycin, kanamycin, tetracycline, and gentamicin.
Antimicrobials Resistance Profiling and Clonal Lineages of Staphylococcus aureus Isolated from Cockroaches in University-Affiliated Hospitals, 2023.
The study identified several aminoglycoside resistance genes (aac(6')-Ie+aph(2"), ant(4')-Ia, aph(3')-IIIa, ant(6)-Ia) and quaternary ammonium compound resistance genes (qacA/B, qacC, qacD, smr) in Staphylococcus aureus isolates from cockroaches in hospital environments. Additionally, the vanA gene was detected in one isolate, indicating vancomycin resistance.
Hospital-associated MRSA genotypes causing complicated community-onset skin and musculoskeletal infections.
The study identified multiple antimicrobial resistance genes, including blaZ and aph(3')-III, in MRSA isolates causing complicated community-onset skin, soft tissue, and musculoskeletal infections. These genes were associated with resistance to beta-lactams and aminoglycosides, highlighting the complexity of resistance mechanisms in these isolates.
Distribution of Staphylococcus aureus drug resistance genes, biofilm formation and cell wall characteristics in dairy cattle from dairy farms in Northeast China.
The study identified various antibiotic resistance genes in Staphylococcus aureus isolates from dairy cattle in Northeast China, including tetM, aph(3')-III, ermC, aac(6')/aph(2'), grlB, gyrB, blaZ, and mecA, which confer resistance to tetracycline, aminoglycosides, erythromycin, fluoroquinolones, and beta-lactams.
Elucidation of population-based bacterial adaptation to antimicrobial treatment by single-cell sequencing analysis of the gut microbiome of a hospital patient.
The study identified 29 ARG subtypes across eight types in 13 known, five unknown, and 18 unclassified species, highlighting the complex and dynamic nature of antimicrobial resistance in the gut microbiome. Notably, the cfr(C) gene was detected in 11 bacterial species following antimicrobial treatment, with mutation patterns characterized in several species.
Drug-resistant genes, virulence characteristics, and molecular typing of clindamycin-resistant Streptococcus agalactiae in late pregnancy.
The study identified several AMR genes and mutations in clindamycin-resistant S. agalactiae, including ermB, mreA, tetM, tetO, aph(3')-III, gyrA, and parC. Mutations in gyrA and parC were associated with levofloxacin resistance.
Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3'5"-aminoglycoside phosphotransferase type III.
Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3'5"-aminoglycoside phosphotransferase type III.
Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3'5"-aminoglycoside phosphotransferase type III.
Aminoglycoside antibiotic phosphotransferases are also serine protein kinases.
The study demonstrates that aminoglycoside phosphotransferases (APHs) can phosphorylate serine residues on protein kinase substrates, indicating a functional relationship between APHs and eukaryotic protein kinases.
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