aph(3')-Ie

View on PubMed

aminoglycoside 3'-phosphotransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to aph(3')-Ie

AMR Rules

Browse AMR rules for aph(3')-Ie

Validation StatusConfirmed2+ DBs

Overview

Validation Method: expression in E. coli BL21, enzyme kinetic analysis, and MIC testing
Drug Classes: kanamycin, neomycin, SISOMICIN, PAROMOMYCIN, KANAMYCIN, RIBOSTAMYCIN
Organisms: Citrobacter gillenii DW61, E. coli DH5α, Pseudomonas aeruginosa ATCC 25922, Citrobacter gillenii
Geographic Location: China
Papers: 1
Databases: Reference Gene CatalogReslit

Papers1

APH(3')-Ie, an aminoglycoside-modifying enzyme discovered in a rabbit-derived Citrobacter gillenii isolate.

PMID 39139766 · 2024

A novel aminoglycoside resistance gene, aph(3')-Ie, was identified in the chromosome of the multidrug-resistant Citrobacter gillenii isolate DW61. This gene confers resistance to several aminoglycosides, including ribostamycin, kanamycin, paromomycin, sisomicin, and neomycin.

Gene Information

Gene Name: aph(3')-Ie
Allele: APH(3')-Ie
Encodes: aminoglycoside 3'-phosphotransferase
Source Database: Reslit
Confers Resistance To: kanamycinneomycin
Organisms Tested In: • Citrobacter gillenii DW61
• E. coli DH5α
• Pseudomonas aeruginosa ATCC 25922
Geographic Location: China
Validation Method: expression in E. coli BL21, enzyme kinetic analysis, and MIC testing
Sequence Accession: CP151088|CP151089|PP596862

APH(3')-Ie, an aminoglycoside-modifying enzyme discovered in a rabbit-derived Citrobacter gillenii isolate.

PMID 39139766 · 2024

Gene Information

Gene Name: aph(3')-Ie
Allele: APH(3')-Ie
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ie
Source Database: Reference Gene Catalog
Confers Resistance To: SISOMICINPAROMOMYCINKANAMYCINRIBOSTAMYCIN
Organisms Tested In: • Citrobacter gillenii
Sequence Accession: PP596862.1
Protein Accession: WYX89017.1

Comments (0)

No comments yet. Be the first to comment!

aph(3')-Ie

View on PubMed

aminoglycoside 3'-phosphotransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to aph(3')-Ie

AMR Rules

Browse AMR rules for aph(3')-Ie

Validation StatusConfirmed2+ DBs

Overview

Validation Method: expression in E. coli BL21, enzyme kinetic analysis, and MIC testing
Drug Classes: kanamycin, neomycin, SISOMICIN, PAROMOMYCIN, KANAMYCIN, RIBOSTAMYCIN
Organisms: Citrobacter gillenii DW61, E. coli DH5α, Pseudomonas aeruginosa ATCC 25922, Citrobacter gillenii
Geographic Location: China
Papers: 1
Databases: Reference Gene CatalogReslit

Papers1

APH(3')-Ie, an aminoglycoside-modifying enzyme discovered in a rabbit-derived Citrobacter gillenii isolate.

PMID 39139766 · 2024

Gene Information

Gene Name: aph(3')-Ie
Allele: APH(3')-Ie
Encodes: aminoglycoside 3'-phosphotransferase
Source Database: Reslit
Confers Resistance To: kanamycinneomycin
Organisms Tested In: • Citrobacter gillenii DW61
• E. coli DH5α
• Pseudomonas aeruginosa ATCC 25922
Geographic Location: China
Validation Method: expression in E. coli BL21, enzyme kinetic analysis, and MIC testing
Sequence Accession: CP151088|CP151089|PP596862

APH(3')-Ie, an aminoglycoside-modifying enzyme discovered in a rabbit-derived Citrobacter gillenii isolate.

PMID 39139766 · 2024

Gene Information

Gene Name: aph(3')-Ie
Allele: APH(3')-Ie
Encodes: aminoglycoside O-phosphotransferase APH(3')-Ie
Source Database: Reference Gene Catalog
Confers Resistance To: SISOMICINPAROMOMYCINKANAMYCINRIBOSTAMYCIN
Organisms Tested In: • Citrobacter gillenii
Sequence Accession: PP596862.1
Protein Accession: WYX89017.1

Comments (0)

No comments yet. Be the first to comment!

aph(3')-Ie

Gene Information

Gene Information

Browse AMR Genes

aph(3')-Ie

Gene Information

Gene Information