aph(5)

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aminoglycoside phosphotransferase

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UniProt

Protein entries specific to aph(5)

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Validation StatusCandidate

Overview

Mechanism: phosphorylation of aminoglycoside antibiotics
Validation Method: purification and characterization via ion exchange chromatography, coupled spectrophotometric assay, and HPLC analysis
Drug Classes: streptomycin
Organisms: Bacillus subtilis subsp. subtilis
Papers: 1
Databases: Reslit

Papers1

Antibiotic resistance and inhibition mechanism of novel aminoglycoside phosphotransferase APH(5) from B. subtilis subsp. subtilis strain RK

PMID 31401782 · 2019

The study identifies a novel aminoglycoside phosphotransferase, APH(5), from Bacillus subtilis subsp. subtilis strain RK, which confers resistance to streptomycin by phosphorylating the 5-OH group of the streptamine ring.

Gene Information

Gene Name: aph(5)
Allele: APH(5)
Encodes: aminoglycoside phosphotransferase
Source Database: Reslit
Mechanism: phosphorylation of aminoglycoside antibiotics
Confers Resistance To: streptomycin
Organisms Tested In: • Bacillus subtilis subsp. subtilis
Validation Method: purification and characterization via ion exchange chromatography, coupled spectrophotometric assay, and HPLC analysis
Sequence Accession: KJ849237.1

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aph(5)

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aph(5)

Gene Information