Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside O-phosphotransferase APH(6)-Id
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| APH(6)-Id | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 343 | STREPTOMYCIN, aminoglycosides +7 | Vibrio cholerae +118 | China, UK, United States, India, Warsaw, Poland, Europe, Tunisia, human|mouse|pig, Global|global, Australia|India, Gothenburg, Africa|Ghana|Kenya|Tanzania, La Paz, Bolivia|La Paz River basin, Sri Lanka, Taiwan|Germany|Netherlands|United Kingdom|United States, British Columbia|British Columbia, Canada, Chongqing|China, Malawi, Greece, Japan, Egypt, Brazil, Norway, Philippines, Canada, Thailand|Nepal, France|New Caledonia|La Réunion Island|French Guiana|French Polynesia|Guadeloupe|Madagascar|Tunisia|India, Jakarta, Armenia|Georgia, Pacific region|Hawaii, Nigeria, Malaysia, South Africa, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, Kenya, Ghana, North America|Asia|Europe|Australia|South America, Beijing, China|China, Europe|Poland, Ontario, Canada|North America, Australia, Romania|Spain, United Kingdom|England|Australia, Colombia, Cambodia, Bangladesh, Thailand, Africa|Gambia, North Carolina|USA, Italy, Portugal, Saudi Arabia, Finland|Eastern Finland, Milwaukee, Wisconsin, USA|USA, Spain, China|Guangdong Province, China, Senegal, Kuwait, North-Western Mexico, Germany, Sudan, North America|Asia|Europe|Middle East|Africa, Hungary, South America, Hong Kong, Ningxia, China|China, Basque Country, northern Spain|Basque Country, South Australia|Australia, New Zealand, Stellenbosch, South Africa, Abuja, Nigeria, Peru, Guadeloupe, Egypt|United States|China, Zhejiang, China|China, Sweden, Brazilian Amazon, Portugal|Spain|Italy|Morocco, India|Iran|UK|China|Brazil|US|Australia, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, France|South Asia|Thailand|Malaysia|Belarus|Spain|Australia|Guatemala|India|Romania|Russia|USA, Ontario, Canada, Oxfordshire, UK, Uruguay, Midwestern U.S.|Nebraska, Belgium|The Netherlands|Europe, Czech Republic|location A|location B|location C, Maryland|California|New York|Pennsylvania, Finland, Pakistan|Karachi, Pakistan, Northern Italy, China|Bolivia|United States|Canada|New Zealand, Brazil|Belgium, Tamaulipas, Mexico, Central Greece, Salish Sea, Uganda, Central Adriatic|Central Adriatic Sea, Tennessee, USA|East Tennessee, Germany|Australia|Taiwan|USA|Canada|Denmark, USA|Honduras|UK|Kenya, Switzerland, France, Peruvian Amazon, Europe|America|Africa, Bangladesh|India|China|France|Brazil, Czech Republic, Bangkok, Thailand, Zanzibar, Guangdong Province, China, Denmark|Finland|Germany, Taiwan, Jiangsu Province|China, Accra, Ghana|Ghana, France|Ecuador|Vietnam|India|Madagascar|Nigeria, Fiji, Inner Mongolian, Poland, United States|Pakistan|Bangladesh|Nigeria|Iraq|India, Ethiopia, Gaza Strip, China|United States|United Kingdom|Canada|Germany|Brazil|Australia, Portugal|various regions, Asia|South America|North America|Europe|Africa, Europe|Canada, Shenzhen|Dapeng, Europe|Czech Republic, Somali region, Ethiopia|Somali Region, Ethiopia, East China, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, Ecuador, South India, Terengganu, Malaysia|Malaysia, Hong Kong|mainland China|Australia|Canada|United States of America|South Africa|Taiwan|United Kingdom, UK|Kuwait, Iowa, United States, Indonesia, Israel, Myanmar, Kano, Nigeria|Nigeria, USA, Western Balkans|Hungary, Costa Rica, China|Lebanon|United States|Poland|France, Argentina, Vietnam, Shandong Province|adjacent regions in China, Paraguay|Northern Spain, Europe|Croatia, China|North America|Asia|Europe|Africa|Other, Victoria, Australia, Europe|Norway|Romania, Atlanta, Australia|France|Bangladesh|United States, China|United Kingdom|Argentina|Europe|Americas|Asia|Africa|Australasia|Vietnam|Switzerland|Thailand|Mexico, Harare, Zimbabwe, New Zealand|United Kingdom|United States|Tunisia|Czechia, Europe|China, Madagascar|Cambodia, Southern Togo|Togo, Central China, United Arab Emirates | 1989, 2004, 2008, 2011, 2013, 2014, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AB114188.1 | BAC79067.1 |
| aph(6)-Id | ResFinder Database | 1 | STREPTOMYCIN | Escherichia coli, Pseudomonas aeruginosa, Actinobacillus pleuropneumoniae, Escherichia coli SMS-3-5 | - | 1989 | M28829, AF024602, AB109805, CP000971, 18676889 | - |
| aph6Id | Reslit | 1 | kanamycin, streptomycin | Escherichia coli | Scotland | 2018 | PRJEB12513 | - |
| aph (6)Id | Reslit | 1 | aminoglycosides | Klebsiella pneumoniae | South Africa | 2019 | CP012043|NXKY01000005.1 | - |
| aph[6]-1d | Reslit | 1 | gentamicin | Salmonella enterica serotype Typhi | Pakistan|Denmark | 2019 | PRJNA543969 | - |
| aph(6)-1d | Reslit | 5 | aminoglycosides, gentamicin +1 | various bacterial species +4 | Vermont|United States, Czech Republic, Kenya|Malawi, Tokyo, Japan|Japan, Cameroon|South Africa | 2019, 2020, 2021, 2022 | PRJNA553636 | - |
| aph (6)-Id | Reslit | 14 | aminoglycosides, gentamicin | Escherichia coli +4 | California|Arizona|South Carolina|Idaho|Maine, Europe, Germany|Central Germany, Denmark, Italy, Zagreb, Croatia|Zagreb|Croatia, Ontario, Canada, India, Bangladesh, Poland, Germany, Armenia, Portugal | 2020, 2021, 2022, 2023, 2024, 2025 | CP043105 | - |
| aph[6]-Id | Reslit | 3 | gentamicin, tobramycin +2 | Klebsiella pneumoniae +2 | Switzerland, Mexico, Europe | 2021 | NZ_CP025457|NZ_CP025577|CP042872|NZ_CP011334|NZ_CP046945 | - |
| aph6-Id | Reslit | 6 | aminoglycosides, gentamicin | Escherichia coli +5 | Europe, Europe|United States, Canada, Western Africa|Mali, California, India | 2021, 2023, 2024, 2025 | MN366356|MN366357|MN366358|MN366359|MN366360|MN366361|JX469829 | - |
| aph_6_Id | Reslit | 1 | aminoglycosides | Salmonella enterica | The Gambia | 2022 | SAMEA6991082|SAMEA6991083|SAMEA6991084|SAMEA6991085|SAMEA6991086|SAMEA6991087|SAMEA6991088|SAMEA6991089|SAMEA6991090|SAMEA6991091|SAMEA6991092|SAMEA6991093|SAMEA6991094|SAMEA6991095|SAMEA6991096|SAMEA6991097|SAMEA6991098|SAMEA6991099|SAMEA6991100|SAMEA6991101|SAMEA6991102|SAMEA6991103|SAMEA6991104|SAMEA6991105|SAMEA6991106|SAMEA6991107|SAMEA6991108|SAMEA6991109|SAMEA6991110|SAMEA6991111|SAMEA6991112|SAMEA6991113|SAMEA6991114|SAMEA6991115|SAMEA6991116|SAMEA6991117|SAMEA6991118|SAMEA6991119|SAMEA6991120|SAMEA6991121|SAMEA6991122|SAMEA6991123|SAMEA6991124|SAMEA6991125|SAMEA6991126|SAMEA6991127|SAMEA6991128|SAMEA6991129|SAMEA6991130|SAMEA6991131|SAMEA6991132|SAMEA6991133|SAMEA6991134|SAMEA6991135|SAMEA6991136|SAMEA6991137|SAMEA6991138|SAMEA6991139|SAMEA6991140|SAMEA6991141|SAMEA6991142|SAMEA6991143|SAMEA6991144|SAMEA6991145|SAMEA6991146|SAMEA6991147|SAMEA6991148|SAMEA6991149|SAMEA6991150|SAMEA6991151|SAMEA6991152|SAMEA6991153|SAMEA6991154|SAMEA6991155|SAMEA6991156|SAMEA6991157|SAMEA6991158|SAMEA6991159|SAMEA6991160|SAMEA6991161|SAMEA6991162|SAMEA6991163|SAMEA6991164|SAMEA6991165|SAMEA6991166|SAMEA6991167|SAMEA6991168|SAMEA6991169|SAMEA6991170|SAMEA6991171|SAMEA6991172|SAMEA6991173|SAMEA6991174|SAMEA6991175|SAMEA6991176|SAMEA6991177|SAMEA6991178|SAMEA6991179|SAMEA6991180 | - |
| aph(6')-1d | Reslit | 1 | aminoglycosides | Escherichia coli | Global | 2022 | PRJNA780590 | - |
| APH6-Id | Reslit | 1 | aminoglycosides | Acinetobacter baumanni +1 | Danakil Depression, Afar Region, Ethiopia | 2023 | - | - |
| aph61d | Reslit | 1 | aminoglycosides | Escherichia coli | Quebec, Canada | 2023 | PRJNA716674|PRJNA1022465 | - |
| APH(6)-1d | Reslit | 1 | aminoglycosides | Mannheimia haemolytica | Saskatchewan | 2024 | PRJNA1088094 | - |
| aph6_Id-1 | Reslit | 1 | aminoglycosides | Klebsiella pneumoniae | China | 2025 | NZ_CP035384|NZ_CP064247|NZ_CP064248|NZ_CP064249|NZ_CP064250|NZ_CP064251|NZ_CP142388|NZ_CP142389|NZ_CP142390|NZ_CP142391|NZ_CP142392|NZ_CP142387|NZ_CP102193|NZ_CP102196|NZ_CP102195|NZ_CP102194|NZ_CP064236|NZ_CP064237|NZ_CP064238|NZ_CP064239|NZ_CP064240|SAMN10790857|SAMN16561282|SAMN16561284|SAMN39449843|SAMN30074657 | - |
| aph (6) -Id | Reslit | 1 | kanamycin, gentamicin | Salmonella enterica serovar Thompson | China | 2025 | NZ_CP029249|NZ_CP041172|NZ_CP050832|NZ_MT560003|NZ_MT56003 | - |
| aph(6 )-Id | Reslit | 1 | aminoglycosides | Morganella morganii | China | 2024 | PRJNA1119085 | - |
| aph(6)-I d | Reslit | 1 | aminoglycosides | Salmonella enterica serotype Enteritidis | Europe|Netherlands | 2025 | PRJEB54672|PRJEB60024 | - |
| APH(6 )-Id | Reslit | 1 | aminoglycosides | Enterobacter hormaechei | Sri Lanka | 2025 | CP165725|CP171250-CP171253|CP178584-CP178587|CP171246-CP171249 | - |
| aph(6′)Id | Reslit | 1 | aminoglycosides | Pseudomonas aeruginosa | Western Balkans|Hungary | 2025 | - | - |
Analysis of the complete nucleotide sequence of an Actinobacillus pleuropneumoniae streptomycin-sulfonamide resistance plasmid, pMS260.
Analysis of the complete nucleotide sequence of an Actinobacillus pleuropneumoniae streptomycin-sulfonamide resistance plasmid, pMS260.
Novel insertion sequence- and transposon-mediated genetic rearrangements in genomic island SGI1 of Salmonella enterica serovar Kentucky.
Novel insertion sequence- and transposon-mediated genetic rearrangements in genomic island SGI1 of Salmonella enterica serovar Kentucky.
Genomic analysis of the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06 widely spread in China.
The study identifies several AMR genes and mutations in the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06, including bla oxa-23, armA, and various efflux pumps, contributing to resistance against multiple antibiotics.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
The study identified various AMR genes and mutations in E. coli and K. pneumoniae isolates, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-15), aminoglycoside-modifying enzymes (aac(6')-Ib-cr, aadA1a, aadA4, aadA5, aph(6')-Id, aph(3')-Ia), and quinolone resistance mutations (gyrA S83L/D87N, parC S80I/E84V). These genes and mutations were validated through whole-genome sequencing and phenotypic testing.
Antimicrobial resistance determinants in Acinetobacter baumannii isolates taken from military treatment facilities.
The study identified multiple antimicrobial resistance genes in Acinetobacter baumannii isolates from military treatment facilities, including bla OXA-51-like, bla OXA-23, bla GES-11, aac(6')-Ib, aacC1, aadB, aphA6, and others, highlighting the complex resistome of these isolates.
Purification and characterization of aminoglycoside phosphotransferase APH(6)-Id, a streptomycin-inactivating enzyme.
The study characterizes APH(6)-Id, a streptomycin-inactivating enzyme that confers resistance to streptomycin when expressed in E. coli.
Resistance determinants and mobile genetic elements of an NDM-1-encoding Klebsiella pneumoniae strain.
The study identifies multiple antibiotic resistance genes in the NDM-1-encoding Klebsiella pneumoniae strain, including eight beta-lactamase genes and various other resistance determinants, highlighting the complexity of its resistance profile.
Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India.
The study identified a diverse array of antibiotic resistance genes in a polluted lake in India, including sul2, qnrD, aph(6)-Id, aph(3′)-Ib, CMY2, qnrS, ant(3′)-Ia, dfrB1/dfrB5/dfrB6/dfrB8, GES, ere(A)/ere(C), qnrC, mph(E), dfrA1/dfrA15/dfrA25/dfrA30, erm(F), ant(2′)-Ia, cmlA, and tet(39). These genes conferred resistance to various classes of antibiotics, highlighting the significant presence of resistance mechanisms in the polluted environment.
Complete nucleotide sequence and gene organization of the broad-host-range plasmid RSF1010.
Complete nucleotide sequence and gene organization of the broad-host-range plasmid RSF1010.
Complete nucleotide sequence and gene organization of the broad-host-range plasmid RSF1010., Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes., Analysis of the complete nucleotide sequence of an Actinobacillus pleuropneumoniae streptomycin-sulfonamide resistance plasmid, pMS260., Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5., Novel insertion sequence- and transposon-mediated genetic rearrangements in genomic island SGI1 of Salmonella enterica serovar Kentucky.
Genome-based insights into the resistome and mobilome of multidrug-resistant Aeromonas sp. ARM81 isolated from wastewater.
The study identified multiple AMR genes in Aeromonas sp. ARM81, including three aminoglycoside resistance genes (aph(3'-VIb), aph(3''-Ib), and aph(6)-Id), a tetracycline efflux gene (tetA(E)), and two β-lactamase genes (blaPER-1 and blaMOX-12).
Susceptibility to Aminoglycosides and Distribution of aph and aac(3)-XI Genes among Corynebacterium striatum Clinical Isolates.
The study identified the presence of the aph(3')-Ic, aph(3")-Ib, aph(6)-Id, and aac(3)-XI genes in Corynebacterium striatum clinical isolates, which confer resistance to various aminoglycosides. These genes were detected through PCR and sequencing, and their association with resistance was confirmed by MIC testing.
Occurrence of Corynebacterium striatum as an emerging antibiotic-resistant nosocomial pathogen in a Tunisian hospital.
The study identifies several AMR genes and mutations in Corynebacterium striatum, including bla, erm(X), erm(B), aph(3')-Ic, aac(3)-XI, aph(3'')-Ib, and aph(6)-Id, along with gyrA mutations contributing to fluoroquinolone resistance.
Genome sequencing of 39 Akkermansia muciniphila isolates reveals its population structure, genomic and functional diverisity, and global distribution in mammalian gut microbiotas.
The study identified the acquisition of antibiotic resistance genes, including sul2, aph(6)-Id, and aph(3"-Ib, through lateral gene transfer in Akkermansia muciniphila GP36, which conferred resistance to sulfonamides and aminoglycosides.
Genetic analysis of invasive Escherichia coli in Scotland reveals determinants of healthcare-associated versus community-acquired infections.
The study identified several antibiotic resistance genes in E. coli isolates, including blaCTX-M-15, blaCTX-M-9, aac(3)-II, aac(6')-Ib, aadA1, dfrA1, sul1, sul2, mphA, and mrxA, which contribute to resistance against various antibiotics such as third-generation cephalosporins, aminoglycosides, trimethoprim, sulfonamides, and macrolides.
Variant O89 O-Antigen of E. coli Is Associated With Group 1 Capsule Loci and Multidrug Resistance.
The study identified a novel O89 O-antigen locus in E. coli strain 26561, which is associated with group 1 capsule (G1C) and multidrug resistance. The strain exhibits a mucoid and viscous phenotype, and possesses multiple AMR genes including blaCTX-M-14, blaTEM-1, aph(3")-Ib, strA, aph(6)-Id, strB, aph(3′)-Ia, sul2, tetA(B), and catA1. Mutations in gyrA (S83L, D87N) and parC (S80I) contribute to quinolone resistance.
Comparative genomics of clinical strains of Pseudomonas aeruginosa strains isolated from different geographic sites.
The study identified several AMR genes in Pseudomonas aeruginosa strains from different geographic locations, including beta-lactamases, aminoglycoside resistance genes, fosfomycin resistance, chloramphenicol resistance, sulfonamide resistance, quaternary ammonium compound resistance, tetracycline resistance, and others. Indian eye isolates exhibited a higher diversity of resistance genes compared to Australian isolates.
Draft genome sequence data of a tigecycline-resistant Enterobacter cloacae ST93 clinical strain isolated from bloodstream infection.
The study reports the draft genome sequence of a tigecycline-resistant Enterobacter cloacae ST93 clinical isolate, TREC1, which harbors multiple antimicrobial resistance genes, including those encoding resistance to beta-lactams, aminoglycosides, fluoroquinolones, fosfomycin, macrolides, lincosamides, streptogramin B, phenicols, sulfonamides, trimethoprim, and tetracyclines. The isolate is resistant to all antibiotics tested except colistin.
The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis.
The study characterized the resistomes of six carbapenem-resistant pathogens, identifying various carbapenemase genes such as bla KPC-2, bla OXA-48, bla OXA-72, bla NDM-1, bla NDM-7, and bla VIM-1, along with other resistance genes like aac(6')-Ib-cr, aph(3")-Ib, aph(6)-Id, tet(B), erm(B), mph(A), sul1, sul2, dfrA17, dfrA14, bla CTX-M-15, bla CMY-6, bla OXA-1, bla SHV-200, bla OXA-10, and bla NDM-7.
The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.
The study identifies multiple AMR genes associated with multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa, including genes encoding resistance to aminoglycosides, beta-lactams, chloramphenicol, trimethoprim, sulfonamides, and tetracyclines. It also notes mutations in the gyrA gene associated with reduced susceptibility to fluoroquinolones.
Diarrheal bacterial pathogens and multi-resistant enterobacteria in the Choqueyapu River in La Paz, Bolivia.
The study identified multidrug-resistant Enterobacteriaceae in the Choqueyapu River, including E. coli and Enterobacter cloacae carrying bla CTX-M, bla KPC, bla NDM, bla VIM, and bla OXA-48 genes, highlighting the environmental spread of antibiotic resistance.
Whole Genome Sequencing of Extended Spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae Isolated from Hospitalized Patients in KwaZulu-Natal, South Africa.
The study characterized multiple AMR genes in ESBL-producing K. pneumoniae isolates, including bla TEM-1B, bla CTX-M-15, bla SHV-1, bla OXA-1, aad AI6, aac (6′)Ib-cr, aph (6)Id, aph (3′)-Ib, oqx A, oqx B, fos A, ARR-3, sul 1, sul 2, dfr A14, dfr A27, cat A1, and cat B4.
Whole-Genome Sequencing Analysis of Nontyphoidal Salmonella enterica of Chicken Meat and Human Origin Under Surveillance in Sri Lanka.
The study identified several AMR genes in nontyphoidal Salmonella enterica isolates from chicken meat and human sources in Sri Lanka, including blaCTX-M-15, fosA7, aph(6)-Id, tet(A), blaTEM-1B, qnrS1, sul3, and dfrA14.
Ceftriaxone-resistant Salmonella enterica serotype Typhi in a pregnant traveller returning from Karachi, Pakistan to Denmark, 2019.
The study reports a ceftriaxone-resistant Salmonella Typhi isolate carrying multiple resistance genes, including blaCTX-M-15, blaTEM-1B, qnrS1, sul1, sul2, dfrA7, aph[3]-1b, aph[6]-1d, aac[6]-1aa, and catA1. Additionally, a fluoroquinolone resistance mutation (gyrA S83F) was identified.
Commonality of Multidrug-Resistant Klebsiella pneumoniae ST348 Isolates in Horses and Humans in Portugal.
Emergence of Multidrug-Resistant Salmonella enterica Serovar Goldcoast Strains in Taiwan and International Spread of the ST358 Clone.
The study identifies multiple multidrug-resistant Salmonella enterica serovar Goldcoast strains in Taiwan, highlighting the emergence of an ST358 clone carrying various resistance genes, including blaCTX-M-55, mcr-1, and others, contributing to the rapid increase in infections.
Identification of Primary Antimicrobial Resistance Drivers in Agricultural Nontyphoidal Salmonella enterica Serovars by Using Machine Learning.
The study identifies CMY-2 beta-lactamase as a primary driver of beta-lactam resistance and APH(6)-Id and APH(3"-Ib as key contributors to streptomycin and tetracycline resistance in agricultural Nontyphoidal Salmonella enterica serovars.
High Prevalence of Metallo-β-Lactamase-Producing Enterobacter cloacae From Three Tertiary Hospitals in China.
The study identified multiple metallo-beta-lactamase genes, including blaNDM-1, blaIMP-26, blaIMP-4, blaIMP-1, blaVIM-4, and blaKPC-2, as major contributors to carbapenem resistance in Enterobacter cloacae isolates from three hospitals in China.
Comparative genomic analysis and multi-drug resistance differences of Acinetobacter baumannii in Chongqing, China.
The study identified 19 drug resistance genes in 10 multidrug-resistant Acinetobacter baumannii strains, with efflux pump genes being the most prevalent. Key genes included aacA4, which had a 19-bp deletion associated with aminoglycoside resistance, and other genes like TEM-1, OXA-23, and ANT(3'')-IIa.
Inter-host Transmission of Carbapenemase-Producing Escherichia coli among Humans and Backyard Animals.
The study identified blaNDM genes as the primary cause of carbapenem resistance in Escherichia coli isolates from humans, pigs, chickens, and flies in rural China, highlighting the transmission of these resistance genes between humans and backyard animals.
Resistome metagenomics from plate to farm: The resistome and microbial composition during food waste feeding and composting on a Vermont poultry farm.
The study identified 50 unique antibiotic resistance genes (ARGs) in food waste, compost, and farm products, with a focus on aminoglycoside, tetracycline, and macrolide resistance. Key ARGs included aph(6)-1d, lmrD, mefA, mel, abeM, abeS, adeF, adeG, adeI, adeJ, adeK, emrD, sul2, tetH, tetM, tetO, tetW, and tetX, which were found in various samples and showed resistance to multiple drug classes.
Emergence of carbapenemase-producing Enterobacteriaceae in Malawi.
The study reports the detection of an NDM-5 producing E. coli in Malawi, highlighting the emergence of carbapenem-resistant Enterobacteriaceae in the region.
Evaluating the genome and resistome of extensively drug-resistant Klebsiella pneumoniae using native DNA and RNA Nanopore sequencing.
The study identified multiple AMR genes in extensively drug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (blaSHV-11, blaTEM-1B, blaVEB-1, blaOXA-10, blaKPC-2, blaOXA-9, blaVIM-27, blaCTX-M-15, blaOXA-1, blaOXA-48), aminoglycoside resistance genes (aadA1, ant(2'')-Ia, aph(6)-Id, arr-2, aadA24, aph(3')-Ia, aph(6)-Id, aac(3)-IIa, aac(6')Ib-cr, aac(6')-Ib, aac(6')-Ib-cr), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet(A), tet(G)), trimethoprim resistance genes (dfrA1, dfrA14, dfrA23), chloramphenicol resistance genes (cmlA1, catB4), and others.
Oral colonisation by antimicrobial-resistant Gram-negative bacteria among long-term care facility residents: prevalence, risk factors, and molecular epidemiology.
The study identified several AMR genes in Gram-negative bacteria isolated from LTCF residents, including bla CTX-M-27, bla CTX-M-14, bla TEM-1B, bla IMP-1, and others, which confer resistance to various antibiotics such as β-lactams, aminoglycosides, and fluoroquinolones.
Genotypic characterization of multiple drug resistant Escherichia coli isolates from a pediatric cancer hospital in Egypt.
The study identified multiple drug-resistant Escherichia coli isolates from a pediatric cancer hospital in Egypt, highlighting the prevalence of various antimicrobial resistance genes such as TEM-220, NDM-11, aph(6)-Id, sul2, and others, indicating a significant threat to immunocompromised patients.
Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report.
Metadata Analysis of mcr-1-Bearing Plasmids Inspired by the Sequencing Evidence for Horizontal Transfer of Antibiotic Resistance Genes Between Polluted River and Wild Birds.
The study identifies the mcr-1 gene as a key factor in colistin resistance in E. coli strains isolated from polluted rivers and wild birds. It also characterizes several other AMR genes including aadA1, aadA2, aph(3′)-Ia, aph(3″)-Ib, aph(4)-Ia, aph(6)-Id, tet(B), tet(D), tet(A), bla CTX–M–14, bla TEM–1, qnrS2, oqxA, oqxB, cmlA1, floR, vgaC, sul1, sul2, sul3, dfrA12, and glpT (E448K).
International clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil.
The study identified various AMR genes in CTX-M-producing E. coli isolates from peri-urban wild animals in Brazil, including bla CTX-M-55, bla CTX-M-2, bla CTX-M-15, bla CTX-M-14, and others, indicating the presence of multidrug-resistant bacteria in wildlife.
Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India.
The study identified several AMR genes and mutations in Salmonella Typhi isolates, including beta-lactamases (blaTEM-1B, blaTEM-116), chloramphenicol resistance gene (catA1), trimethoprim resistance genes (dfrA7, dfrA15), sulfamethoxazole resistance genes (sul1, sul2), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE genes.
Nanopore sequencing reveals genomic map of CTX-M-type extended-spectrum β-lactamases carried by Escherichia coli strains isolated from blue mussels (Mytilus edulis) in Norway.
The study identified CTX-M-type extended-spectrum beta-lactamases in Escherichia coli strains isolated from blue mussels in Norway, highlighting the potential for mobility of these resistance genes.
Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines.
The study identifies various carbapenemase genes such as blaNDM-1, blaNDM-7, blaCTX-M-15, and blaOXA-181, along with other AMR genes like rmtC, sul1, aac(6')-Ib-cr, mph(A), qnrB1, and others, which contribute to resistance against multiple antibiotics in Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa in the Philippines.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
The study identifies multiple AMR genes and mutations in MDR E. coli strains from captive wild animals, highlighting the presence of CTX-M-8 and CTX-M-65 beta-lactamases, along with various other resistance mechanisms such as aminoglycoside, tetracycline, and fluoroquinolone resistance genes, as well as mutations in quinolone resistance-determining regions.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
The study identified multiple AMR genes and mutations in E. coli isolates from diseased chickens in the Czech Republic, highlighting the presence of multidrug-resistant strains with resistance to β-lactams, quinolones, sulfonamides, and tetracyclines.
Genomic characterization of multidrug-resistant ESBL-producing Escherichia coli ST58 causing fatal colibacillosis in critically endangered Brazilian merganser (Mergus octosetaceus).
The study identifies a multidrug-resistant ESBL-producing E. coli ST58 strain (PMPU) isolated from a critically endangered Brazilian merganser, carrying genes conferring resistance to various antibiotics, heavy metals, and disinfectants, along with fluoroquinolone resistance mutations.
Characterization of Extremely Drug-Resistant and Hypervirulent Acinetobacter baumannii AB030.
AB030 exhibits resistance to multiple antibiotics, including carbapenems, fluoroquinolones, aminoglycosides, and tigecycline. Key resistance genes include blaOXA-65, blaOXA-23, aac(3)-IIa, aac(6')-Ian, APH(3"-Ib, and APH(6)-Id. Mutations in gyrA, parC, and rpsJ contribute to fluoroquinolone and tigecycline resistance.
Reservoirs of antimicrobial resistance genes in retail raw milk.
The study identifies multiple antimicrobial resistance genes in retail raw milk, including bla CMY-2, aph (3')-Ib, aph (6)-Id, bla TEM-1B, mdf(A), catA2, sul2, tet(B), and dfrA14, which confer resistance to various antibiotics. These genes were found in E. coli and other bacteria, and some were transferable between species.
Antibiotic Resistance Patterns of Pseudomonas spp. Isolated From Raw Milk Revealed by Whole Genome Sequencing.
The study identified various AMR genes and mutations in Pseudomonas spp. isolated from raw milk, highlighting the prevalence of multidrug-resistant strains and the presence of resistance determinants such as beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps.
Occurrence and Antimicrobial Resistance Traits of Escherichia coli from Wild Birds and Rodents in Singapore.
Identification of a Cluster of Extended-spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Sequence Type 101 Isolated From Food and Humans.
The study identifies a cluster of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae sequence type 101 isolated from food and humans, highlighting the potential role of food as a source of multidrug-resistant bacteria transmission to humans.
Comparative Genomic Analysis of 450 Strains of Salmonella enterica Isolated from Diseased Animals.
The study identified 60 antimicrobial resistance genes (ARGs), 4 disinfectant resistance genes (DRGs), and 33 heavy metal resistance genes (HMRGs) in 450 Salmonella strains isolated from diseased animals. These genes contributed to resistance against multiple antimicrobial classes, including aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and phenicols.
Genomic analysis reveals high virulence and antibiotic resistance amongst phage susceptible Acinetobacter baumannii.
The study identified multiple antibiotic resistance genes in phage-susceptible Acinetobacter baumannii strains, including sulfonamide, tetracycline, beta-lactam, aminoglycoside, macrolide, and phenicol resistance genes. These findings highlight the complex resistance profiles of these strains and their potential implications for therapeutic strategies.
Characteristics and Epidemiology of Extended-Spectrum β-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae From Red Kangaroo, China.
The study identified multiple AMR genes in a multidrug-resistant Klebsiella pneumoniae isolate from a Red Kangaroo, including beta-lactamases (bla DHA–3, bla SHV–1, bla CTX–M–14, bla TEM–191, bla TEM–1, bla CTX–M–3), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aac(3)-IIa, aac(6′)-Ib-cr, aadA16, arr-3), quinolone resistance genes (qnrS1, qnrB2), macrolide resistance gene (mphA), sulfonamide resistance genes (sul3, sul1), dihydrofolate reductase (dfrA3, dfrA27), chloramphenicol resistance gene (floR), tetracycline resistance genes (tetG, tetR), and multidrug efflux pump (qacEΔ1).
Salmonella identified in pigs in Kenya and Malawi reveals the potential for zoonotic transmission in emerging pork markets.
The study identified several AMR genes in Salmonella isolates from pigs in Kenya and Malawi, including dfrA14, sul2, aph(3''-1b), aph(6)-1d, blaTEM-1B, fosA7, tet(A), and tet(J). A single isolate with a gyrA(D87Y) mutation showed resistance to pefloxacin.
Population genomics and antimicrobial resistance in Corynebacterium diphtheriae.
The study identifies several AMR genes in Corynebacterium diphtheriae, including pbp2m associated with penicillin resistance, ermX for macrolide resistance, and various genes for tetracycline, aminoglycoside, and sulfonamide resistance.
Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species.
Four tet(X) variants (tet(X3), tet(X4), tet(X5.2), and tet(X5.3)) were identified in Acinetobacter species, showing high-level resistance to tigecycline, tetracycline, eravacycline, and omadacycline. These genes were found in multiple Acinetobacter species and were associated with IS CR2 elements, facilitating their spread.
Genomic epidemiology of Escherichia coli isolates from a tertiary referral center in Lilongwe, Malawi.
The study identifies the blaCTX-M-15 gene as a major contributor to cephalosporin resistance in Escherichia coli isolates from Malawi, along with other AMR genes such as aac(3)-IIa, aac(3)-IId, aadA5, ant(3'')-Ih, aph(3'')-Ib, aph(3')-Ia, aph(6)-Id, strA, strB, acrF, emrD, mdtM, blaTEM-1, catA1, catB3, dfrA17, sul2, mph(A), and tet(A).
Fecal Klebsiella pneumoniae Carriage Is Intermittent and of High Clonal Diversity.
The study identified 25 antibiotic resistance genes in 80 Klebsiella pneumoniae isolates, primarily encoding efflux pumps and inactivating enzymes. Notably, blaSHV, emrB, emrR, marA, marR, msbA, ompK37, oqxA, oqxB, acrA, vgaC, fosA, tet(D), APH(3")-Ib, APH(6)-Id, aadA, qnrS2, rpoB2, mexF, and oprN were found to confer resistance to various antibiotics.
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing.
The study identified various AMR genes in E. coli isolates from bloodstream infections, including genes conferring resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, and trimethoprim. Additionally, mutations in quinolone resistance-determining regions of gyrA, parC, and parE were associated with ciprofloxacin resistance.
Antimicrobial resistance and gene regulation in Enteroaggregative Escherichia coli from Egyptian children with diarrhoea: Similarities and differences.
The study identified multiple antibiotic resistance genes in Enteroaggregative Escherichia coli (EAEC) isolates from Egyptian children with diarrhea, including bla CTX-M-14b, bla CTX-M-15, bla TEM-1B, aadA1, aph (3')-Ib, aph (3')-Ia, aph (6)-Id, dfrA1, mdfA, sul2, and tetA, which contribute to multidrug resistance.
Colistin-resistant Enterobacter kobei carrying mcr-9.1 and bla(CTX-M-15) infecting a critically endangered franciscana dolphin (Pontoporia blainvillei), Brazil.
The study reports the emergence of the mcr-9.1 gene in a colistin-resistant Enterobacter kobei strain isolated from a critically endangered franciscana dolphin in Brazil, along with various other AMR genes.
Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal Salmonella enterica.
The study identified several β-lactamase genes, including bla CTX-M-5, bla OXA-1, bla CTX-M-15, bla CTX-M-3, and bla TEM-1, which contribute to extended-spectrum β-lactamase (ESBL) production in multidrug-resistant non-typhoidal Salmonella enterica isolates. Additionally, a mutation in the gyrA gene (D87N) was linked to quinolone resistance.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
Antibiotic resistance plasmid composition and architecture in Escherichia coli isolates from meat.
The study characterizes various AMR genes in plasmids from meat-derived E. coli isolates, highlighting the diversity and clustering of resistance genes such as bla CTX-M-1, aadA5, sul2, and others, along with their association with specific plasmid incompatibility groups.
Genomic Analysis of Antimicrobial Resistance and Resistance Plasmids in Salmonella Serovars from Poultry in Nigeria.
The study identified various antimicrobial resistance genes in Salmonella isolates from Nigerian poultry, including aac(6')-Ia, aac(6')-Ib, aadA7, aph(3")-Ia, aph(3")-Ib, aph(6')-Id, aph(6')-Ic, aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-IIa, aac(3)-Id, sul1, sul2, sul3, tet(A), tet(M), qnrS1, qnrB19, blaTEM, dfrA14, dfrA15, dfrA17, catA1, cmlA1, and floR. Mutations in gyrA (Ser83Phe, Asp87Tyr) and parC (Thr57Ser, Ser80Ile) were also associated with resistance to nalidixic acid and ciprofloxacin.
Complete Genome Sequencing of Acinetobacter baumannii AC1633 and Acinetobacter nosocomialis AC1530 Unveils a Large Multidrug-Resistant Plasmid Encoding the NDM-1 and OXA-58 Carbapenemases.
The study identifies a large multidrug-resistant plasmid in Acinetobacter baumannii AC1633 and Acinetobacter nosocomialis AC1530 carrying the NDM-1 and OXA-58 carbapenemases, along with other resistance genes such as aac(3)-IId, aph(6)-Id, aph(3")-Ib, sul2, msrE, mphE, and tetA(39).
Resistome of a carbapenemase-producing novel ST232 Klebsiella michiganensis isolate from urban hospital effluent in South Africa.
The study reports the first carbapenemase-producing Klebsiella michiganensis isolate from South African hospital effluent, harboring multiple resistance genes including blaOXA-181, blaOXY-5-1, qnrB6, qnrS1, aadA16, aac(6')-Ib-cr, aph(6)-Id, arr-3, sul1, sul2, dfrA14, and dfrA27.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya.
The study identified various carbapenemase genes (blaNDM-1, blaNDM-5, blaVIM-1, blaVIM-6, blaOXA-23, blaOXA-58, blaOXA-66, blaOXA-69, blaOXA-91, blaOXA-181, blaOXA-50) and other resistance genes (such as armA, rmtC, rmtF, aac(3)-I, aadA1, aph(3')-Ia, aph(3')-VI, aph(3')-Via, aph(6')-Id, mphE, msrE, mphA, ereA, dfrA1, dfrA12, dfrA14, dfrA17, dfrA20, sul1, sul2, tetB, tetD, tetG, tet39, qnrVC1, qnrS1, qnrB4, floR, catA1, catA2, catB3, catB7, cmlA1, cmlA5, arr-3, arr-2, sat2, acrF, mdtM, emrD, mexA, mexE, mexX, kdeA, oxa-10, oxa-395, oxa-396, oxa-846, adc-25, dha-1, act-16, cmY, ctx-m-15, shv-67, tem-1b) in carbapenem non-susceptible clinical isolates of gram-negative bacteria in Kenya, highlighting the diversity and prevalence of multidrug resistance.
Molecular investigation of an outbreak associated with total parenteral nutrition contaminated with NDM-producing Leclercia adecarboxylata.
The study identified NDM-1, TEM-1B, and SHV-12 carbapenemase genes along with various other AMR genes in Leclercia adecarboxylata isolates causing an outbreak linked to contaminated TPN.
Institutional outbreak involving multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 at a cancer center in Tokyo, Japan.
The study identified multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 (ST78) strains causing an institutional outbreak. These strains carried blaIMP-1 and blaIMP-11 genes on IncHI2 and IncL/M plasmids, along with various other resistance genes such as aac(6')-IIc, qnrB6, fosA, sul1, and tet(B).
Clonal Clusters, Molecular Resistance Mechanisms and Virulence Factors of Gram-Negative Bacteria Isolated from Chronic Wounds in Ghana.
The study identified various AMR genes and mutations in Gram-negative bacteria isolated from chronic wounds in Ghana, including beta-lactamases, fosfomycin resistance genes, chloramphenicol resistance genes, aminoglycoside resistance genes, fluoroquinolone resistance genes, tetracycline resistance genes, sulfonamide resistance genes, trimethoprim resistance genes, and efflux pumps. Mutations in gyrA, parE, and parC were also found to contribute to fluoroquinolone resistance.
Genomic diversity and molecular epidemiology of Pasteurella multocida.
This study identified several antimicrobial resistance genes in Pasteurella multocida, including aminoglycoside, beta-lactam, tetracycline, macrolide, and sulfonamide resistance genes, highlighting the diverse resistance mechanisms present in this pathogen.
Genomic Characterization of Salmonella enterica Isolates From Retail Meat in Beijing, China.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from retail meat in Beijing, including beta-lactamases (blaCTX-M-55, blaCTX-M-14, blaCTX-M-65), aminoglycoside resistance genes (aac(6')-Iaa, aph(6)-Id, aph(3")-Ib), sulfonamide resistance gene (sul2), beta-lactamase (blaTEM-1B), quinolone resistance genes (qnrS1), and colistin resistance genes (mcr-1.1, mcr-9).
High-Level Aminoglycoside Resistance in Human Clinical Klebsiella pneumoniae Complex Isolates and Characteristics of armA-Carrying IncHI5 Plasmids.
The study identified armA and multiple aminoglycoside resistance genes (AMEs) on a conjugative IncHI5 plasmid in a high-level aminoglycoside-resistant Klebsiella variicola isolate. The plasmid p2757-346 carried two copies of armA along with six AME genes, highlighting the potential for dissemination of these resistance determinants.
Antimicrobial Resistance Glides in the Sky-Free-Living Birds as a Reservoir of Resistant Escherichia coli With Zoonotic Potential.
The study identified multiple AMR genes and mutations in E. coli from free-living birds, highlighting the zoonotic potential of these resistant strains. Key findings include bla CTX-M-15, bla CMY-2, bla SHV-12, bla TEM-1B, qnrS1, qnrB19, mcr-1, fosA7, aac(3)-IIa, ant(3")-Ia, aph(3")-Ib, and aph(6)-Id, as well as mutations in gyrA, parC, and parE.
On-Farm Anaerobic Digestion of Dairy Manure Reduces the Abundance of Antibiotic Resistance-Associated Gene Targets and the Potential for Plasmid Transfer.
The study found that anaerobic digestion of dairy manure significantly reduced the abundance of antibiotic resistance genes, including various ESBL genes such as bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, and bla PER-1, as well as other resistance genes like aac(6')-Ib-cr, aph(3')-Ib, aph(6)-Id, bla OXA-1, catB4, dfrA1, floR, lnu(G), sul2, aadA2, mph(E), msr(E), tet(C), tet(E), and tet(X).
Characterization of beta-lactam-resistant Escherichia coli from Australian fruit bats indicates anthropogenic origins.
The study identified various beta-lactam-resistant Escherichia coli strains from Australian fruit bats, highlighting the presence of multiple AMR genes such as bla TEM-1A, bla TEM-1B, bla CTX-M-27, bla NDM-5, and others, indicating anthropogenic origins of these resistant strains.
Biosolids as a Source of Antibiotic Resistance Plasmids for Commensal and Pathogenic Bacteria.
Six unique resistance plasmids were identified that can transfer to Salmonella typhimurium, Klebsiella aerogenes, and E. coli, carrying 3-6 antibiotic resistance genes conferring resistance to 2-4 antibiotic classes.
Subtypes, resistance and virulence platforms in extended-drug resistant Acinetobacter baumannii Romanian isolates.
The study identifies several AMR genes including bla OXA-23, bla OXA-24, bla OXA-51, and various aminoglycoside, sulfonamide, tetracycline, and macrolide resistance genes in XDR A. baumannii isolates from Romania.
Achromobacter spp. genetic adaptation in cystic fibrosis.
The study identifies various beta-lactamase genes (blaOXA-258, blaOXA-114, blaOXA-243, blaOXA-455, blaOXA-457, blaOXA-458, blaOXA-459) and the catB10 gene conferring chloramphenicol resistance in Achromobacter spp. Additionally, the axyZ gene is highlighted as a key factor in multidrug resistance.
Genomic evolution of antimicrobial resistance in Escherichia coli.
The study identified several AMR genes in Escherichia coli isolates from different animal sources in Europe, including blaTEM-1B, qnrB19, qnrS1, sul1, sul2, sul3, tet(A), aadA1, and aph(6)-Id. These genes were associated with resistance to beta-lactams, fluoroquinolones, sulfonamides, tetracyclines, and aminoglycosides.
Acquisition and loss of CTX-M plasmids in Shigella species associated with MSM transmission in the UK.
The study identifies the presence of bla CTX-M-27, erm(B), mph(A), aph(3')-Ib, aph(6)-Id, sul2, and tet(A) in Shigella isolates associated with MSM transmission in the UK, highlighting the role of plasmids in the spread of antimicrobial resistance.
Phylum barrier and Escherichia coli intra-species phylogeny drive the acquisition of antibiotic-resistance genes.
The study analyzed 70,301 E. coli genomes and identified 1,027,651 antibiotic-resistance genes (ARGs). It found that certain ARGs were distributed according to the phylogenetic background of the strains, showing phenotypic adaptive convergence. The study also identified four instances of potential horizontal gene transfer of ARGs from non-Proteobacteria to E. coli.
Genetic Diversity of Multidrug-Resistant Pseudomonas aeruginosa Isolates Carrying bla (VIM-2) and bla (KPC-2) Genes That Spread on Different Genetic Environment in Colombia.
The study identifies bla(VIM-2) and bla(KPC-2) genes in multidrug-resistant Pseudomonas aeruginosa isolates from Colombia, highlighting their diverse genetic environments and mechanisms of resistance.
Antimicrobial resistance and genomic characterization of Salmonella Dublin isolates in cattle from the United States.
The study characterized multidrug-resistant Salmonella Dublin isolates from cattle in the United States, identifying key AMR genes such as sul2, tetA, aph(6)-Id, aph(3''-Ib, floR, and blaCMY-2, along with quinolone resistance mutations in gyrA.
Antimicrobial Resistance and Comparative Genome Analysis of Klebsiella pneumoniae Strains Isolated in Egypt.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant K. pneumoniae strain KPE16, including bla NDM-1, bla CTX-M-15, and various aminoglycoside, sulfonamide, and tetracycline resistance genes. Additionally, chromosomal mutations in ompK36, ompK37, and acrR contribute to resistance.
Genotypic and Phenotypic Characterization of Antimicrobial Resistance Profiles in Non-typhoidal Salmonella enterica Strains Isolated From Cambodian Informal Markets.
The study identified 17 unique AMR genes in 53% of the 81 S. enterica isolates, including genes encoding resistance to tetracycline, beta-lactam, sulfonamide, quinolone, aminoglycoside, phenicol, and trimethoprim.
International High-Risk Clones Among Extended-Spectrum β-Lactamase-Producing Escherichia coli in Dhaka, Bangladesh.
The study identified several AMR genes and mutations in ESBL-producing E. coli isolates from Dhaka, Bangladesh, including bla CTX-M-15, bla NDM-5, mcr-1, and various aminoglycoside resistance genes. Mutations in gyrA and parC were also associated with fluoroquinolone resistance.
Sequence Analyses and Phenotypic Characterization Revealed Multidrug Resistant Gene Insertions in the Genomic Region Encompassing Phase 2 Flagellin Encoding fljAB Genes in Monophasic Variant Salmonella enterica Serovar 4,5,12:i:- Isolates From Various Sources in Thailand.
The study identified multiple multidrug resistance genes, including blaTEM-1B, strA, strB, sul2, and tetB, in Salmonella enterica serovar 4,5,12:i:- isolates from Thailand, which contribute to resistance against ampicillin, streptomycin, sulfonamides, and tetracycline.
Investigation of the Genes Involved in the Outbreaks of Escherichia coli and Salmonella spp. in the United States.
The study identified several antimicrobial resistance genes in E. coli and Salmonella spp., including aadA1, aph(3"-Ib, aph(6)-Id, blaTEM-1, sul2, tet(A), and tet(B) in E. coli, and arsA, arsB, arsC, iroB, and iroC in Salmonella spp. Additionally, virulence genes such as epeA, stxA2d, stxB2c, subA, and subB were found to be unique to outbreak E. coli.
Multidrug Resistance Dynamics in Salmonella in Food Animals in the United States: An Analysis of Genomes from Public Databases.
The study analyzed 22,102 Salmonella genomes from public databases to track antimicrobial resistance (AMR) trends in food animals in the United States. It found that the prevalence of multidrug resistance (MDR) decreased in bovines and swine but increased in poultry. Key AMR genes identified include bla CMY-2, bla CTX-M-65, floR, tetA, sul2, aadA2, aac(3)-VIa, qnrB19, qnrB2, bla SHV-12, bla TEM-1, bla CARB-2, aph(3")-Ib, aph(6)-Id, aph(3')-Ia, ant(3")-Ia, aph(4)-Ia, and aac(3)-IVa. A significant mutation, gyrA D87Y, was associated with quinolone resistance in poultry.
Whole-Genomic Analysis of NDM-5-Producing Enterobacteriaceae Recovered from an Urban River in China.
The study identified multiple antimicrobial resistance genes, including bla NDM-5, bla OXA-10, and bla TEM-1B, in NDM-5-producing Enterobacteriaceae isolates from an urban river in China. These genes conferred resistance to various antibiotics such as carbapenems, cephalosporins, quinolones, and aminoglycosides.
Invasive atypical non-typhoidal Salmonella serovars in The Gambia.
The study identified several antimicrobial resistance genes in invasive Salmonella serovars in The Gambia, including blaTEM-1B, aph(3'')-Ib, aph(6)-Id, catA1, dfrA7, sul1, sul2, tet(B), and fosA7. These genes conferred resistance to various antibiotics such as ampicillin, penicillin, gentamicin, kanamycin, tobramycin, chloramphenicol, trimethoprim, sulfamethoxazole, tetracycline, and fluoroquinolones.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
The study identified various CTX-M-type beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, bla CTX-M-55, and bla CTX-M-65, as well as other beta-lactamase genes such as bla TEM-1, bla CARB-2, and bla CMY-2 in ESBL E. coli isolates from sheep and their abattoir environment. Additional AMR genes related to aminoglycosides, macrolides, phenicols, quinolones, sulfonamides, tetracyclines, and trimethoprim were also detected.
Colistin Resistance Onset Strategies and Genomic Mosaicism in Clinical Acinetobacter baumannii Lineages.
The study identifies various AMR genes and mutations associated with colistin resistance in clinical Acinetobacter baumannii strains, highlighting the genomic diversity and mosaicism in resistance mechanisms.
First report from Bangladesh on genetic diversity of multidrug-resistant Pasteurella multocida type B:2 in fowl cholera.
The study identified multidrug-resistant Pasteurella multocida type B:2 strains in fowl cholera cases in Bangladesh, highlighting the presence of various virulence factors and antimicrobial resistance genes.
Mouse pneumonia model by Acinetobacter baumannii multidrug resistant strains: Comparison between intranasal inoculation, intratracheal instillation and oropharyngeal aspiration techniques.
The study identified various AMR genes in two multidrug-resistant Acinetobacter baumannii strains, ACC001 and ACC002, including aminoglycoside resistance genes, tetracycline resistance genes, beta-lactamases, and sulfonamide resistance genes. These genes contribute to resistance against multiple antibiotics such as gentamicin, tobramycin, tetracycline, penicillins, cephalosporins, and sulfonamides.
Letter to the Editor: Importation of the First Bovine ST361 New Delhi Metallo-5 Positive Escherichia coli in Greece.
The study reports the first bovine ST361 NDM-5 positive Escherichia coli in Greece, highlighting the importation of multidrug-resistant strains and the need for continued surveillance.
Genomic characteristics and comparative genomics of Salmonella enterica subsp. enterica serovar Schwarzengrund strain S16 isolated from chicken feces.
NDM-1 Introduction in Portugal through a ST11 KL105 Klebsiella pneumoniae Widespread in Europe.
The study characterizes the first recognized outbreak of NDM-1-producing K. pneumoniae in Portugal, highlighting the introduction of a new ST11 KL105 strain carrying blaNDM-1 in a unique genetic context. Several antibiotic resistance genes, including blaNDM-1, blaCTX-M-15, and others, were identified, along with chromosomal mutations conferring reduced susceptibility to fluoroquinolones and fosfomycin.
Antibacterial Efficacy of Liposomal Formulations Containing Tobramycin and N-Acetylcysteine against Tobramycin-Resistant Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii.
The study identified various aminoglycoside-modifying enzymes (AMEs) and efflux pump genes contributing to tobramycin resistance in E. coli, K. pneumoniae, and A. baumannii. These genes include acc(3)-IIa, aac(6')-Ib-cr, ant(2")-Ia, aph(6)-Id, aph(3")-Ib, armA, rmtF, acrD, adeA, adeB, adeC, ompA, omp37, csgB, csgD, csgF, csgG, pgaA, pgaB, pgaC, pgaD, csuA, csuB, csuC, csuD, csuE, and bap.
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
The study identified several beta-lactamase genes, including bla CTX-M-27, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla SHV-12, and bla TEM-1, which confer resistance to beta-lactam antibiotics. Other resistance genes such as aadA5, aph(3")-Ib, aph(6)-Id, mph(A), sul1, sul2, tet(A), and dfrA17, dfrA12, dfrA1, and dfrA14 were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates in Finland.
Escherichia fergusonii, an Underrated Repository for Antimicrobial Resistance in Food Animals.
The study identified multiple antimicrobial resistance (AMR) genes in Escherichia fergusonii isolates from food animals, including mcr-1, aph(6)-Id, aph(3')-Ib, and tet(A). These genes contribute to resistance against colistin, aminoglycosides, and tetracycline, highlighting E. fergusonii as a significant reservoir of AMR genes.
S. algae as a reservoir and a vehicle of potential antimicrobial resistance
The study identified multiple antimicrobial resistance genes in S. algae strains, including genes conferring resistance to beta-lactams, aminoglycosides, quinolones, phenicols, macrolides, sulfonamides, tetracyclines, and lincosamides.
Prevalence, Antimicrobial Resistance, and Whole Genome Sequencing Analysis of Shiga Toxin-Producing Escherichia coli (STEC) and Enteropathogenic Escherichia coli (EPEC) from Imported Foods in China during 2015-2021.
The study identified several antimicrobial resistance genes in STEC and EPEC isolates from imported foods in China, including blaTEM-1B, tetA, tetB, catA1, cmlA1, aadA1, aph(4)-Ia, aac(3)-IV, aph(6)-Id, aph(3")-Ib, sul3, dfrA12, and qnrS1, which conferred resistance to various antibiotics such as ampicillin, tetracycline, chloramphenicol, gentamicin, trimethoprim-sulfamethoxazole, and ciprofloxacin.
First Description of Ceftazidime/Avibactam Resistance in a ST13 KPC-70-Producing Klebsiella pneumoniae Strain from Portugal.
The study reports the first description of ceftazidime/avibactam resistance in a ST13 KPC-70-producing Klebsiella pneumoniae strain from Portugal. The strain was found to harbor the blaKPC-70 gene, a variant of blaKPC-3 with two amino acid substitutions (D179Y and T263A), which conferred resistance to several β-lactam antibiotics.
Similarities in Virulence and Extended Spectrum Beta-Lactamase Gene Profiles among Cefotaxime-Resistant Escherichia coli Wastewater and Clinical Isolates.
The study identifies several beta-lactamase genes, including blaCTX-M-1, blaKPC-2, blaTEM-350, blaOXA-1, and blaCTX-M-15, as well as various aminoglycoside, macrolide, and tetracycline resistance genes in cefotaxime-resistant E. coli isolates from hospital and urban wastewater. Mutations in parC, parE, and gyrA contribute to fluoroquinolone resistance.
Pan-Genome Analysis of Delftia tsuruhatensis Reveals Important Traits Concerning the Genetic Diversity, Pathogenicity, and Biotechnological Properties of the Species.
The study identifies multiple antimicrobial resistance genes in Delftia tsuruhatensis, including aminoglycoside, sulfonamide, trimethoprim, tetracycline, and phenicol resistance genes, indicating the potential for multidrug resistance in this species.
Genomic characterization of multidrug-resistant Salmonella serovar Kentucky ST198 isolated in poultry flocks in Spain (2011-2017).
The study identified multiple antimicrobial resistance genes in multidrug-resistant Salmonella serovar Kentucky ST198 isolates from Spain, including genes conferring resistance to aminoglycosides, beta-lactams, sulfonamides, tetracyclines, trimethoprim, and colistin.
Whole genome sequence of pan drug-resistant clinical isolate of Acinetobacter baumannii ST1890.
The study identified multiple antibiotic resistance genes in the pan-drug-resistant Acinetobacter baumannii strain VJR422, including genes encoding beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps, contributing to resistance against various antibiotic classes.
Antibiotic Combination Therapy: A Strategy to Overcome Bacterial Resistance to Aminoglycoside Antibiotics.
The paper discusses the mechanisms of bacterial resistance to aminoglycoside antibiotics, including enzymatic modification, decreased drug accumulation, and modification of drug targets. It highlights the importance of understanding these mechanisms to develop strategies to overcome resistance.
A Metagenomic Approach for Characterizing Antibiotic Resistance Genes in Specific Bacterial Populations: Demonstration with Escherichia coli in Cattle Manure.
The study identified multiple antibiotic resistance genes in E. coli populations from cattle manure, including genes conferring resistance to tetracycline, aminoglycosides, chloramphenicol, sulfonamides, and glycopeptides. These genes were found to be associated with mobile genetic elements, highlighting the potential for horizontal gene transfer.
Classification of 27 Corynebacterium kroppenstedtii-Like Isolates Associated with Mastitis in China and Descriptions of C. parakroppenstedtii sp. nov. and C. pseudokroppenstedtii sp. nov.
The study identifies two new species, Corynebacterium parakroppenstedtii and Corynebacterium pseudokroppenstedtii, and characterizes antibiotic resistance genes including APH(3')-Ia, APH(3'')-Ib, APH(6)-Id, erm(X), sul1, and tet(W) in C. kroppenstedtii-like isolates.
Virulome and genome analyses identify associations between antimicrobial resistance genes and virulence factors in highly drug-resistant Escherichia coli isolated from veal calves.
The study identifies multiple antimicrobial resistance genes (ARGs) in highly drug-resistant Escherichia coli isolates from veal calves, including blaCMY-2, blaCTX-M-15, mph(A), erm(B), aac(6')-Ib-cr, qnrS1, aadA5, aadA1, aph(3')-Ic, aph(3')-Ia, aph(3')-Ib, aph(6')-Id, sul1, sul2, tet(A), and tet(B). Additionally, mutations in gyrA (S83L, D87N) and parC (A56T) were found to contribute to fluoroquinolone resistance.
Genomic diversity and antimicrobial resistance among non-typhoidal Salmonella associated with human disease in The Gambia.
The study identified various antimicrobial resistance (AMR) genes in non-typhoidal Salmonella isolates from The Gambia, including aac(6')-Iaa_1, aph_3_Ib, aph_6_Id, dfrA14, dfrA7, dfrA8, blaTEM-1B, catA1_1, fosA7_1, mph_A, sul1, sul2, tet_A, and tet_B. These genes confer resistance to aminoglycosides, trimethoprim, beta-lactams, chloramphenicol, fosfomycin, macrolides, sulfonamides, and tetracyclines. The study also found that multidrug resistance (MDR) was primarily associated with Salmonella serovar Enteritidis, especially in the eastern region.
Genomics of human and chicken Salmonella isolates in Senegal: Broilers as a source of antimicrobial resistance and potentially invasive nontyphoidal salmonellosis infections.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella isolates from Senegal, highlighting the prevalence of resistance to fluoroquinolones, sulfamethoxazole-trimethoprim, tetracycline, and erythromycin. Key genes included aac(3)-Id, aadA7, blaTEM-1b, blaDHA-1, blaOXA-10, blaCMY-2, dfrA1, dfrA14, floR, fosA, qnrB19, qnrB7, sul2, tetA, tetB, aph(3')-Ib, aph(3")-Ib, and aph(6)-Id. Mutations in parC and gyrA were also associated with fluoroquinolone resistance.
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
The study identified multiple AMR genes in multidrug-resistant E. coli and K. pneumoniae isolates from Kuwait, including beta-lactamases (blaKPC-2, blaCTX-M-15, blaOXA-1, blaCMY-4, blaTEM), aminoglycoside-modifying enzymes (aac(3)-IIa, aph(6)-Id, aadA5), sulfonamide resistance genes (sul1, sul2), quinolone resistance genes (gyrA_D87N, qnrB1), and others. Colistin resistance was linked to the pmrB_R256G mutation.
Genomic Profiling of Antibiotic-Resistant Escherichia coli Isolates from Surface Water of Agricultural Drainage in North-Western Mexico: Detection of the International High-Risk Lineages ST410 and ST617.
The study identified multidrug-resistant Escherichia coli isolates from surface water in north-western Mexico, including international high-risk lineages ST410 and ST617. These isolates carried various AMR genes such as blaTEM-1B, blaCTX-M-15, aadA1, aadA2, aadA5, aac(3)-IIa, aac(3)-IId, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, floR, cmlA1, lnu(F), mdf(A), sul2, sul3, tet(A), tet(B), dfrA12, and dfrA17. Additionally, mutations in gyrA (S83L, D87N), parC (S80I), and parE (S458A) were found to contribute to fluoroquinolone resistance.
Identifying the Sources of Intestinal Colonization With Extended-Spectrum β-Lactamase-Producing Escherichia coli in Healthy Infants in the Community.
The study identifies several AMR genes, including blaCTX-M-15, qnrS1, ermB, aadA1, aph(3')-Ib, aph(6)-Id, dfrA1, catA1, aadA2, dfrA5, dfrA12, qnrS13, aac(6')-Ib-cr5, blaTEM-1, blaOXA-1, sul1, and dfrA17, associated with ESBL-Ec in children, mothers, and drinking water in rural Bangladesh.
In vitro Synergistic Activities of Fosfomycin in Combination with Other Antimicrobial Agents Against Carbapenem-Resistant Escherichia coli Harboring bla (NDM-1) on the IncN2 Plasmid and a Study of the Genomic Characteristics of These Pathogens.
The study identified several AMR genes in bla NDM-1 -harboring CREC isolates, including bla NDM-1, aac(3)-IId, aph(3")-Ib, aph(6)-Id, aadA5, aadA16, aac(6')-Ib-cr, qnrB6, ARR-3, dfrA17, dfrA27, sul1, sul2, tet(A), mph(A), bla TEM-1C, bla TEM-57, bla CTX-M-14, bla CTX-M-15, and bla CMY-2. These genes conferred resistance to various antibiotics, including carbapenems, aminoglycosides, fluoroquinolones, rifampicin, trimethoprim, sulfonamides, tetracycline, and macrolides.
Genomic and resistome analysis of Alcaligenes faecalis strain PGB1 by Nanopore MinION and Illumina Technologies.
The study identified several antibiotic resistance genes in Alcaligenes faecalis strain PGB1, including aph(3'), bla, aph(3'')-Ib, and aph(6)-Id, which confer resistance to aminoglycosides and beta-lactams.
Comparison of Two Distinct Subpopulations of Klebsiella pneumoniae ST16 Co-Occurring in a Single Patient.
The study identifies multiple AMR genes and mutations in Klebsiella pneumoniae ST16 isolates, including bla NDM-4, bla OXA-181, and a frameshift mutation in acrR, contributing to carbapenem and fluoroquinolone resistance.
Characterization of qnrB-carrying plasmids from ESBL- and non-ESBL-producing Escherichia coli.
The study characterized qnrB-carrying plasmids from ESBL- and non-ESBL-producing E. coli, identifying qnrB1, qnrB2, and qnrB19 as major quinolone resistance determinants. These plasmids were found to be self-transmissible and associated with various resistance genes.
Occurrence and Genomic Characterization of Clone ST1193 Clonotype 14-64 in Uncomplicated Urinary Tract Infections Caused by Escherichia coli in Spain.
The study identified the occurrence of fluoroquinolone-resistant ST1193 clone in uncomplicated urinary tract infections (uUTI) caused by Escherichia coli in Spain. Several AMR genes and mutations were characterized, including blaTEM-1B, aph(3')-Ib, aph(6)-Id, mdf(A), mph(A), sul2, dfrA14, dfrA17, sitABCD, and chromosomal mutations in gyrA (S83L, D87N), parC (S80I), and parE (L416F).
Genomic Analysis of Multidrug-Resistant Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Strain Lacking the Hypermucoviscous Regulators (rmpA/rmpA2).
The study identified multiple antimicrobial resistance genes in a multidrug-resistant hypervirulent Klebsiella pneumoniae strain, including beta-lactamases, sulfonamide resistance genes, fosfomycin resistance genes, aminoglycoside resistance genes, and tetracycline resistance genes.
Escherichia coli ST1193: Following in the Footsteps of E. coli ST131
The paper characterizes Escherichia coli ST1193 as an emerging multidrug-resistant clone with various AMR determinants, including beta-lactamases (bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-55, bla OXA-1, bla TEM-1, bla CMY-42, bla CMY-2), aminoglycoside-modifying enzymes (aac(3)-IIa, aac(3)-IId, aac(6′)-Ib-cr, aadA1, aadA2, aadA5, aph(3′′)-Ib, aph(6)-Id), and other resistance genes (mcr-1, mph(A), erm(B), dfrA8, dfrA12, dfrA17, sul1, sul2, tetA, tetB).
Occurrence of bla(NDM-1)-Positive Providencia spp. in a Pig Farm of China.
Four bla NDM-1-positive Providencia strains were identified in a pig farm in China, showing multidrug resistance and carrying additional resistance genes such as bla OXA-10, bla TEM-116, and others.
Characterization of β-Lactamases and Multidrug Resistance Mechanisms in Enterobacterales from Hospital Effluents and Wastewater Treatment Plant.
The study identified several β-lactamase genes, including bla CTX-M-27, bla TEM-1, bla CTX-M-15, bla CTX-M-30, and bla SHV-12, along with a variety of other AMR genes such as aadA5, aph(3''-Ib), aph(6)-Id, aac(3)-IIa, sul1, sul2, dfrA17, dfrA14, qnrB1, tet(A), mph(A), qacE∆, and catB3, which confer resistance to various antibiotics in Enterobacterales isolated from hospital effluents and wastewater treatment plants.
Genomic Analysis of a Highly Virulent NDM-1-Producing Escherichia coli ST162 Infecting a Pygmy Sperm Whale (Kogia breviceps) in South America.
The study identifies a multidrug-resistant NDM-1-producing E. coli ST162 strain isolated from a pygmy sperm whale, highlighting the presence of various AMR genes including blaNDM-1, blaTEM-1C, blaOXA-1, and others, as well as mutations in gyrA and parC contributing to fluoroquinolone resistance.
Genetic Analysis of Carbapenem-Resistant Acinetobacter baumannii Isolates from India: Identification of Resistance Islands and Mobile Genetic Elements
This study identified various AMR genes including blaOXA-23, blaNDM-1, aph(3')-Ib, aph(6)-Id, armA, mph, msr, cmlA1, ARR-2, sul1, sul2, tet(B), and blaPER-7 in carbapenem-resistant Acinetobacter baumannii isolates from India. These genes were found to be associated with resistance islands and mobile genetic elements, contributing to the spread of multidrug resistance.
Prediction of Antibiotic Susceptibility Profiles of Vibrio cholerae Isolates From Whole Genome Illumina and Nanopore Sequencing Data: CholerAegon.
The study presents CholerAegon, a bioinformatics pipeline for predicting antimicrobial resistance profiles from whole genome sequencing data of Vibrio cholerae. It identifies AMR genes such as dfrA1, sul2, catB9, and floR, and detects mutations like D476N in parE that contribute to fluoroquinolone resistance.
Insights into mobile genetic elements and the role of conjugative plasmid in transferring aminoglycoside resistance in extensively drug-resistant Acinetobacter baumannii AB329.
The study identified several AMR genes in the extensively drug-resistant Acinetobacter baumannii AB329, including beta-lactamases (blaOXA-51, blaADC-25, blaOXA-23, blaTEM-1D), aminoglycoside resistance genes (aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, armA), tetracycline resistance genes (tet(B), tet(R)), and macrolide resistance genes (mph(E), msr(E)). Additionally, the aminoglycoside resistance gene aph(3')-VIa was found on the conjugative plasmid pAB329b, which was shown to transfer resistance to sodium azide-resistant A. baumannii.
Genome Analysis of ESBL-Producing Escherichia coli Isolated from Pigs.
The study identified several AMR genes in ESBL-producing E. coli isolates from pigs, including blaCTX-M-15, aminoglycoside resistance genes, qnrS1, and mcr-1, highlighting the presence of multidrug-resistant strains with potential implications for human health.
Serotype Diversity and Antimicrobial Resistance Profile of Salmonella enterica Isolates From Freshwater Turtles Sold for Human Consumption in Wet Markets in Hong Kong.
The study identifies the multidrug-resistance gene cfr for the first time in Salmonella, highlighting the expansion of the cfr reservoir and potential horizontal spread to other bacteria. It also detects various AMR genes such as floR, sul2, aph(3')-Ia, aph(3”)-Ib, aph(6)-Id, aac(6')-Ib-cr, bla CMY−2, bla TEM−1, qnrS1, erm(B), mph(E), msr(E), qepA8, arr-3, sul1, dfrA12, dfrA27, tet(A), tet(D), catB3, aadA16, aac(3)-IV, aph(4)-Ia, aadA2, and fosA7.
Whole-genome sequencing-based prediction and analysis of antimicrobial resistance in Yersinia enterocolitica from Ningxia, China.
The study identified several AMR genes in Yersinia enterocolitica isolates from Ningxia, China, including aph(6)-Id, aph(3")-Ib, sul2, tet(A), tet(Y), and y56, which confer resistance to various antibiotics such as ampicillin, streptomycin, trimethoprim/sulfamethoxazole, tetracycline, and others. These genes were validated through whole-genome sequencing and resistance gene prediction.
Within-farm dynamics of ESBL-producing Escherichia coli in dairy cattle: Resistance profiles and molecular characterization by long-read whole-genome sequencing.
The study identified multiple ESBL-encoding genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, and bla SHV-12, as well as carbapenemase gene bla NDM-1, in ESBL-producing E. coli isolates from dairy cattle farms. These genes were associated with resistance to various beta-lactam antibiotics. Additionally, several other AMR genes such as aadA2, ant(3")-Ia, aph(3')-Ia, dfrA12, sul3, cmlA1, and others were identified, contributing to resistance against aminoglycosides, trimethoprim, sulfamethoxazole, and chloramphenicol. Mutations in gyrA, parC, and parE were linked to fluoroquinolone resistance.
Emergence of a Novel NDM-5-Producing Sequence Type 4523 Klebsiella pneumoniae Strain Causing Bloodstream Infection in China.
The study identifies a novel sequence type 4523 Klebsiella pneumoniae strain, ST4523, which is resistant to multiple antibiotics, including carbapenems, and carries the bla NDM-5 gene on a plasmid. The strain also possesses various other resistance genes on plasmids pSHX180-1 and pSHX180-NDM5.
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil.
The study characterizes antimicrobial resistance (AMR) genes and mutations in various Salmonella serovars associated with poultry in Brazil, emphasizing the emergence of multidrug-resistant (MDR) strains. Key findings include the identification of AMR genes such as blaCTX-M-2, blaTEM-1B, aac(3)-lla, aac(3)-lld, aadA1, aadA2, aph(6)-ld, dfrA1, floR, mrc-1, strA, strB, sul1, sul2, tet(A), tet(B), and others, which confer resistance to multiple antibiotics.
High Prevalence of Beta-Lactam-Resistant Escherichia coli in South Australian Grey-Headed Flying Fox Pups (Pteropus poliocephalus).
The study identified various beta-lactam-resistant Escherichia coli strains in South Australian grey-headed flying fox pups, including resistance genes such as blaTEM-1B, blaTEM-1C, blaTEM-33, blaCMY-2, dfrA17, aadA5, dfrA5, sul2, tet(A), tet(B), and catA1.
Prevalence and distribution of extended-spectrum β-lactamase and AmpC-producing Escherichia coli in two New Zealand dairy farm environments.
The study identified bla CMY-2, bla CTX-M-1, bla CTX-M-15, and bla OXA-1 genes in ESBL- and AmpC-producing E. coli isolates from New Zealand dairy farms, highlighting the presence of plasmid-mediated resistance mechanisms.
Spatiotemporal Investigation of Antibiotic Resistance in the Urban Water Cycle Influenced by Environmental and Anthropogenic Activity.
The study identified several AMR genes, including carbapenemases (cphA5, cphA7, imiH, ESP-1), colistin resistance gene mcr-7.1, aminoglycoside resistance genes (aadA, aph(6)-Id, aph(3')-Ib), sulfonamide/trimethoprim resistance genes (sul1, dfrA15, dfrA14), and multidrug efflux pumps (MexB, OpmH, MexK) in various bacterial isolates from urban water samples.
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria.
The study identified several AMR genes in multi-drug resistant E. coli isolates, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-65, bla OXA-1, bla OXA-2, bla CMY-2, bla NDM-1, bla NDM-5, aac(3)-IId, aac(3)-IIe, aac(6')-Ib-cr, aad A5, ant(2′′)-Ia, aph(3′′)-Ib, aph(3′′)-VI, aph(6)-Id, ermB, ermD, fosA3, fosA7, mdtM, emrD, sul1, sul2, sul3, tetA, tetB, tetM, dfrA1, dfrA7, dfrA8, dfrA12, dfrA14, dfrA17, dfrA82, dfrB4, qepA, qepA1, qepA2, qepA4, qnrB19, qnrS1, qacE, catA1, catA2, catB3, cmlA1, mphA.
Phenotypic and Genotypic Analysis of Antimicrobial Resistance in Escherichia coli Recovered from Feedlot Beef Cattle in Australia.
The study identified several AMR genes in E. coli from feedlot beef cattle, including tet(B), aph(3"-Ib, aph(6)-Id, bla TEM-1B, sul2, bla TEM, bla CTX m, and bla CMY, which confer resistance to tetracyclines, aminoglycosides, beta-lactams, and sulfonamides.
Genomic characteristics of clinical multidrug-resistant Proteus isolates from a tertiary care hospital in southwest China.
The study identifies multiple AMR genes in clinical multidrug-resistant Proteus isolates, including bla CTX-M-65, bla OXA-1, bla KPC-2, bla NDM-1, and others, highlighting the genetic diversity of mobile genetic elements carrying resistance genes.
Resistance Phenotype and Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Nanjing Children's Hospital in Jiangsu Province, China.
The study identified several carbapenemase genes, including blaKPC-2, blaNDM-1, blaNDM-5, blaIMP-8, and blaOXA-181, as well as other resistance genes such as blaCTX-M, blaSHV-2, APH(3)-IB, APH(6)-ID, FosA5, tetC, qnrB1, and tetA, contributing to multidrug resistance in CRKP strains isolated from children in Nanjing, China.
WGS-Based Lineage and Antimicrobial Resistance Pattern of Salmonella Typhimurium Isolated during 2000-2017 in Peru.
The study identifies 63 different AMR genes in 90 S. Typhimurium isolates from Peru, including beta-lactamases (blaTEM-181, blaSHV-12, blaSHV-134, blaCTX-M-15), quinolone resistance genes (qnrB5, qnrB19, qnrE2), tetracycline resistance genes (tetA, tetD, tetR), sulfonamide resistance genes (sul3), dihydrofolate reductase (dfrA1, dfrA12), florfenicol resistance gene (floR), lincomycin resistance gene (linG), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aadA2), colistin resistance gene (mcr-1), and fosfomycin resistance gene (fosA3).
Comparative Genomic Analysis of Antimicrobial-Resistant Escherichia coli from South American Camelids in Central Germany.
The study identified various antimicrobial resistance genes in Escherichia coli isolates from South American camelids in Germany, highlighting the presence of multidrug-resistant strains and the importance of monitoring AMR in these animals.
Acquisition of genomic elements were pivotal for the success of Escherichia coli ST410
The study identified several AMR genes and mutations in Escherichia coli ST410, including bla OXA-181, bla NDM-5, bla CTX-M-15, and mutations in gyrA, parC, and parE that confer resistance to carbapenems, cephalosporins, penicillins, aminoglycosides, sulfonamides, trimethoprim, and fluoroquinolones.
Emergence of a Novel Lineage and Wide Spread of a bla(CTX-M-15)/IncHI2/ST1 Plasmid among Nosocomial Enterobacter in Guadeloupe.
The study identifies the bla CTX-M-15 gene as the most prevalent ESBL determinant in ESBL-producing Enterobacter cloacae complex isolates, along with the IncHI2/ST1 plasmid. It also reports the presence of other resistance genes such as mcr-9, aac(3)-IIa, aac(6′)-Ib-cr, aph(3″)-Ib, aph(6)-Id, bla OXA-1, bla TEM-1B, qnrB1, fosA, sul2, tet(A), dfrA14, ars, mer, tni, and the ter operon.
Isolation of extended-spectrum β-lactamase-producing Escherichia coli from Japanese red fox (Vulpes vulpes japonica).
Two CTX-resistant Escherichia coli strains were isolated from Japanese red fox fecal samples, harboring various AMR genes and mutations. One strain carried aph(3")-Ib, aph(3')-Ia, aph(6)-Id, mdf(A), sitABCD, sul2, tet(A), and tet(B), while the other had gyrA(S83L), parC(S80I, E84V), and parE(I529L) mutations along with mdf(A) and sitABCD.
Pathogenome comparison and global phylogeny of Escherichia coli ST1485 strains.
The study identifies multiple antibiotic resistance genes, including blaTEM-1, aph(3')-Ib, aph(6)-Id, sul2, dfrA14, and mcr-1, in Escherichia coli ST1485 strains, highlighting their multidrug-resistant nature and potential zoonotic risk.
Whole-Genome Sequencing-Based Species Classification, Multilocus Sequence Typing, and Antimicrobial Resistance Mechanism Analysis of the Enterobacter cloacae Complex in Southern China.
The study identified 80 antibiotic resistance genes in 172 Enterobacter cloacae complex isolates, with a focus on beta-lactamases, aminoglycosides, and fluoroquinolones. Key genes included blaACT-2, blaACT-3, blaACT-6, blaACT-9, blaACT-12, blaTEM-1D, blaCTX-M-3, blaSHV-12, blaNDM-1, blaNDM-5, blaIMP-1, blaIMP-4, blaIMP-26, blaKPC-2, qnrS2, qnrE1, aac(6')-Ib, aac(6')-IIc, aph(3')-Ib, aph(6)-Id, aadA, sul2, dfrA12, tetA, ereA, floR, catA2, mcr-10, arr-6, and fosA3.
Vaginal Bacteria in Mares and the Occurrence of Antimicrobial Resistance.
The study identified several AMR genes in E. coli isolates from mares, including dfrA14 for trimethoprim resistance, mdf(A) for chloramphenicol resistance, sul2 for sulfonamide resistance, blaEC for beta-lactam resistance, and aph(6)-Id for streptomycin resistance.
Characterization of antibiotic-resistance traits in Akkermansia muciniphila strains of human origin.
The study identified several AMR genes in Akkermansia muciniphila strains, including adeF, tetW, sul2, and aph(6)-Id. Only the strain Amap1 showed resistance to tetracycline due to the presence of tetW. The presence of ARGs does not always translate into a resistant phenotype.
Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.
The study identified ESBL-producing E. coli in river water in northern Thailand, with bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27 being the most prevalent beta-lactamase genes. Additionally, mcr-1.1 and mcr-3.4 genes were found to confer resistance to colistin. Various other resistance genes were also characterized, including aac(3)-IId, aadA5, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, aac(6′)-Ib-cr, qnrS1, mdf(A), erm(B), mph(A), floR, sul2, sul3, tet(A), tet(X), tet(M), dfrA12, dfrA14, dfrA17, cmlA1, catA2, lnu(F), and erm(42).
Antimicrobial resistance and genomic characterization of Salmonella enterica serovar Senftenberg isolates in production animals from the United States.
The study characterized antimicrobial resistance genes and mutations in Salmonella enterica serovar Senftenberg isolates from production animals in the United States, identifying genes such as aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, blaTEM-1B, blaCMY-2, blaSHV-12, floR, catA2, qnrB2, aac(6')-Ib-cr, aadA1, aadA2, sul1, sul2, tetA, and mcr-9.1, along with mutations in gyrA and parC genes contributing to resistance against various antibiotics.
Characterization of Escherichia coli and other bacteria isolated from condemned broilers at a Danish abattoir.
The study identified several AMR genes in E. coli isolates from condemned broiler carcasses, including beta-lactamase genes (bla TEM-1B, bla TEM-1C, bla TEM-220, bla TEM-106, bla TEM-135, bla TEM-126, bla TEM-127), sulfonamide resistance gene (sul 2), aminoglycoside resistance genes (aph (6)-Id, aph (3")-Ib, aph (3')-Ia, aad A1, aad A5, aac (3)- Via), trimethoprim resistance genes (dfr A1, dfr A14, dfr A15, dfr A17), tetracycline resistance genes (tet (A), tet (B)), and a macrolide resistance gene (mdf (A)).
The hazard of carbapenemase (OXA-181)-producing Escherichia coli spreading in pig and veal calf holdings in Italy in the genomics era: Risk of spill over and spill back between humans and animals.
The study identifies multiple AMR genes, including bla OXA-181, bla TEM-1B, aac (3)-IId, aad A2, cml A1, dfr A12, mef (B), sul 3, tet (A), tet (M), incX3, incX1, incFII, qnr S1, aph (3″)-Ib, aph (6)-Id, flo R, lnu (F), sul 2, sul 3, tet (B), mph (A), mph (G), qnr B4, rmt B, and fos A3, in OXA-181-producing E. coli isolates from pigs and bovines in Italy. These genes confer resistance to various antibiotics, including carbapenems, cephalosporins, penicillins, aminoglycosides, trimethoprim, macrolides, sulfonamides, tetracyclines, fluoroquinolones, and fosfomycin.
Mobile colistin resistance (MCR), extended-spectrum beta-lactamase (ESBL) and multidrug resistance monitoring in Escherichia coli (commensal and pathogenic) in pig farming: need of harmonized guidelines and clinical breakpoints.
The study identified mcr-1 and mcr-4 genes conferring colistin resistance, along with blaTEM-1B, aph(3")-Ib, aph(6)-Id, sul2, and tet(A) genes responsible for resistance to various antibiotics in E. coli isolates from pig farming.
The pan-genome of the emerging multidrug-resistant pathogen Corynebacterium striatum.
The study identifies 15 antimicrobial resistance genes in Corynebacterium striatum, including genes conferring resistance to aminoglycosides, tetracyclines, chloramphenicol, macrolides, lincosamides, streptogramins, sulfonamides, and cationic antiseptics. These genes are often located in genomic islands and mobile genetic elements, highlighting the role of horizontal gene transfer in the spread of multidrug resistance.
Genomic Analysis of Klebsiella pneumoniae ST258 Strain Coproducing KPC-2 and CTX-M-14 Isolated from Poultry in the Brazilian Amazon Region.
The study characterizes a multidrug-resistant Klebsiella pneumoniae ST258 strain (KP411) isolated from poultry in the Brazilian Amazon, which carries several AMR genes including blaKPC-2, blaCTX-M-14, and others, highlighting the potential of food-producing animals as reservoirs of MDR clones.
Resistome and virulome diversity of foodborne pathogens isolated from artisanal food production chain of animal origin in the Mediterranean region.
The study identified various AMR genes in L. monocytogenes, Salmonella enterica, and S. aureus isolates from artisanal food production chains in the Mediterranean region, highlighting the presence of fosfomycin, aminoglycoside, beta-lactam, trimethoprim, sulfonamide, tetracycline, and streptomycin resistance mechanisms.
Comparative Genome Analysis of 19 Trueperella pyogenes Strains Originating from Different Animal Species Reveal a Genetically Diverse Open Pan-Genome.
The study identified 40 antibiotic resistance genes (ARGs) in 19 Trueperella pyogenes strains, including genes conferring resistance to aminoglycosides, tetracyclines, phenicols, sulfonamides, and macrolides.
Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb.
The study identified several AMR genes in multidrug-resistant bacteria isolated from a COVID-19 hospital in Zagreb, including bla CTX-M-15 in E. coli and various bla OXA variants in A. baumannii. These genes conferred resistance to beta-lactams and aminoglycosides.
Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009-2018.
The study identifies multiple AMR genes associated with multidrug-resistant Salmonella enterica serotype 4,[5],12:i:-, including genes conferring resistance to ampicillin, streptomycin, sulfamethoxazole, tetracycline, ciprofloxacin, ceftriaxone, azithromycin, and colistin. These genes are prevalent in a multidrug-resistant clade linked to pork consumption.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Multidrug-resistant toxigenic Corynebacterium diphtheriae sublineage 453 with two novel resistance genomic islands.
Two multidrug-resistant toxigenic Corynebacterium diphtheriae isolates were analyzed, revealing two novel resistance genomic islands carrying 12 resistance genes, including ermX, cmx, aph(3')-Ib, aph(6)-Id, aadA1, dfrA15, sul1, cmlA, cmlR, and tet(33). Additionally, mutations in rpoB and gyrA were associated with resistance to rifampicin and ciprofloxacin, respectively.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
In silico analyses of diversity and dissemination of antimicrobial resistance genes and mobile genetics elements, for plasmids of enteric pathogens.
The study identifies a diverse array of antimicrobial resistance (AMR) genes across various plasmid replicon types in enteric pathogens, highlighting the prevalence of resistance genes in plasmids such as IncHI2, IncN, IncA/C, IncP, IncHI1, and IncFIA. Key AMR genes include aac(3)-IId, aac(3)-IIg, aac(6')-Ib3, aadA1, aadA5, aph(3'')-Ib, bla CMY-2, bla CTX-M-27, bla NDM-1, mcr-9.1, and others, which confer resistance to antibiotics such as gentamicin, cephalosporins, carbapenems, colistin, and tetracycline.
Epidemiology and Genetic Characteristics of Carbapenem-Resistant Escherichia coli in Chinese Intensive Care Unit Analyzed by Whole-Genome Sequencing: a Prospective Observational Study.
The study identified bla KPC-2 and bla NDM-5 as the main carbapenem resistance genes in carbapenem-resistant Escherichia coli (CREC) isolates. Additionally, various other resistance genes were detected, including extended-spectrum beta-lactamases (CTX-M-14, CTX-M-15, CTX-M-27, CTX-M-3, OXA-1, OXA-10, TEM-1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-Iva, aac(6′)-Ib-AKT, aac(6′)-Ib-D181Y, aadA1, aadA2, aadA5, aph(3″)-Ib, aph(3′)-Ia, aph(4)-Ia, aph(6)-Id), quinolone resistance genes (qnrS1, qnrS2), tetracycline resistance genes (oqxA10, oqxB17), fosfomycin resistance gene (fosA3), and chloramphenicol resistance genes (cmlA1, cmlA5).
Correlations among Antibiotic Resistance Genes, Mobile Genetic Elements and Microbial Communities in Municipal Sewage Treatment Plants Revealed by High-Throughput Sequencing.
The study identifies various tetracycline resistance genes (tetC, tetE, tetG, tetM, tetO, tetQ, tetW, tetX), sulfonamide resistance gene (sulI), aminoglycoside resistance genes (ant(2')-Ia, ant(3')-Ia, aph(6')-Id, aph(33')-Ib, aac(6')-Ib), beta-lactam resistance genes (blaGES, blaVEB), chloramphenicol resistance gene (catB3), MLS resistance genes (ereA, ermB), and multidrug resistance genes (acrB, mexB, mexF) in municipal sewage treatment plants, highlighting their association with mobile genetic elements and microbial communities.
Antimicrobial resistance profiles of Campylobacter jejuni and Salmonella spp. isolated from enteritis patients in Japan.
The study identified several AMR genes including blaCMY-2, aac(6')-Iaa, ant(3")-Ib, aph(6)-Id, floR, qnrB19, sul2, and tet(A) in cefotaxime-resistant Salmonella isolates. Additionally, mutations in the gyrA gene, specifically Thr86Ile, were found in ciprofloxacin-resistant C. jejuni isolates.
Enterobacterales plasmid sharing amongst human bloodstream infections, livestock, wastewater, and waterway niches in Oxfordshire, UK.
The study identifies various AMR genes, including bla TEM-1, aph(3'')-Ib, aph(6)-Id, dfrA5, sul2, and robA, which are associated with plasmids shared among human bloodstream infections, livestock, wastewater, and waterways in Oxfordshire, UK.
Phenotypic and genotypic survey of antibiotic resistance in Salmonella enterica isolates from dairy farms in Uruguay.
The study identified 21 AMR genes in Salmonella enterica isolates from dairy farms in Uruguay, including genes conferring resistance to aminoglycosides, tetracyclines, sulfonamides, beta-lactams, and quinolones. Two chromosomal mutations, parC_T57S and acrB_R717Q, were also detected, contributing to resistance against quinolones and azithromycin, respectively.
Genomic Characterization of Carbapenem-Resistant Acinetobacter baumannii (CRAB) in Mechanically Ventilated COVID-19 Patients and Impact of Infection Control Measures on Reducing CRAB Circulation during the Second Wave of the SARS-CoV-2 Pandemic in Milan, Italy.
The study identified various AMR genes in CRAB isolates, including blaOXA-23, aph(3''-Ib, aph(6)-Id, abeM, mexT, abeS, tetA, adeABC, adeJKL, OXA-66, ADC-73, OXA-127, and ADC-30, which contribute to resistance against carbapenems, aminoglycosides, fluoroquinolones, macrolides, tetracyclines, and multiple antibiotics.
Genomic Diversity, Antimicrobial Susceptibility, and Biofilm Formation of Clinical Acinetobacter baumannii Isolates from Horses.
The study identified multiple AMR genes in equine Acinetobacter baumannii isolates, including beta-lactamases (bla OXA-51-like, bla ADC-25, bla TEM-1D), sulfonamide resistance genes (sul1, sul2), chloramphenicol resistance genes (catA1, ABUW 0982), tetracycline resistance genes (tet(A), tet(B), tet(39)), and aminoglycoside modifying enzymes (aph(3′)-Ia, aph(3`)-Ic, aph(6)-Id, aac(3)-Ia). Additionally, eight novel OXA-51-like variants (OXA-970 to OXA-977) were characterized.
Association of ISVsa3 with Multidrug Resistance in Salmonella enterica Isolates from Cattle (Bos taurus).
The study found that multidrug resistance (MDR) in Salmonella enterica isolates from cattle is strongly associated with the presence of IS Vsa3, an IS91-like transposase. The MDR genes, including floR, tet(A), aph(6)-Id, aph(3"-Ib, sul2, and bla CMY-2, were often located on IncC plasmids carrying IS Vsa3.
Exploiting a targeted resistome sequencing approach in assessing antimicrobial resistance in retail foods.
The study identifies a wide array of antimicrobial resistance genes in retail food samples, highlighting the significant role of Enterobacteriaceae in carrying these resistance determinants. The targeted resistome sequencing approach effectively detects and characterizes these genes, demonstrating its superiority over traditional shotgun metagenomics.
The temporal dynamics of antimicrobial-resistant Salmonella enterica and predominant serovars in China.
The study identifies multiple antimicrobial resistance genes in Salmonella enterica isolates from China, highlighting the increasing prevalence of resistance to beta-lactams, quinolones, tetracyclines, and sulfonamides. Key genes include blaTEM-1B, blaCTX-M-14, aac(3)-IV, and mcr-1.
Antimicrobial resistance and genomic characterization of Salmonella enterica isolates from chicken meat.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from chicken meat, including aminoglycoside, beta-lactam, quinolone, tetracycline, sulfonamide, and phenicol resistance genes. These genes were detected using whole genome sequencing and correlated with phenotypic resistance profiles.
High Genetic Diversity of Carbapenem-Resistant Acinetobacter baumannii Isolates Recovered in Nigerian Hospitals in 2016 to 2020.
The study identified blaOXA-23 and blaNDM-1 as the most common carbapenem resistance genes in Acinetobacter baumannii isolates from Nigerian hospitals, along with several other AMR genes and mutations contributing to multidrug resistance.
Investigating Possible Interspecies Communication of Plasmids Associated with Transfer of Third-Generation Cephalosporin, Quinolone, and Colistin Resistance Between Simultaneously Isolated Escherichia Coli and Klebsiella Pneumoniae.
The study identified multiple AMR genes in E. coli and K. pneumoniae isolates, including bla CTX-M-14, qnrS1, mcr-1.1, and others, highlighting the role of plasmids in the transfer of resistance genes between species.
Virotyping and genetic antimicrobial susceptibility testing of porcine ETEC/STEC strains and associated plasmid types.
The study identified several AMR genes and mutations in porcine ETEC/STEC strains, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-106), polymyxin resistance genes (mcr-1.1, mcr-2.1, mcr-5.1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-IV, aac(3)-IVa, aph(3')-Ia, aadA1, aadA10, aadA12), florfenicol resistance gene (floR), tetracycline resistance genes (tet(A), tet(B)), quinolone resistance gene (qnrS1), and trimethoprim-sulfamethoxazole resistance genes (dfrA1, dfrA5, dfrA12, dfrA14, dfrA36).
Molecular epidemiology of enterically colonizing Escherichia coli with resistance against third-generation cephalosporins isolated from stool samples of European soldiers with concomitant diarrhea on deployment in Western African Mali.
The study identified bla CTX-M-15 and bla TEM-1b as the primary genes responsible for third-generation cephalosporin resistance in E. coli isolates from European soldiers in Mali. Additionally, several quinolone resistance genes including qnrS1, gyrA S83L, gyrA D87N, parE S458T, parE S458A, and parC S80I were found. Trimethoprim-sulfamethoxazole resistance was mediated by sul1, sul2, dfrA1, dfrA5, dfrA14, and dfrA17. Gentamicin resistance was associated with aph6-Id, aph3-Ib, aac3-IId, aadA5, and aac6-Ib-cr5. Tetracycline resistance was conferred by tetA, tetB, and tetD.
Hospital and community wastewater as a source of multidrug-resistant ESBL-producing Escherichia coli.
The study identifies several AMR genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-1, bla GES-5, bla OXA-244, qnrS1, qnrB4, aac(3)-IId, aph(3'')-Ib, aph(6)-Id, catA1, cmlA1, and bla TEM-1, which confer resistance to various antibiotics in multidrug-resistant ESBL-producing E. coli isolates from hospital and environmental sources.
Clinical and Bacterial Characteristics Associated with Glove and Gown Contamination by Carbapenem-Resistant Klebsiella pneumoniae in the Health Care Setting.
The study identified various carbapenem resistance genes such as bla KPC, bla KPC-3, bla KPC-2, bla NDM, and bla OXA-232, as well as aminoglycoside resistance genes like aph(6)-Id, aph(3″)-Ib, and others. It also found sulfonamide resistance genes (sul1, sul2, sul3), beta-lactam resistance genes (bla TEM, bla OXA), and quinolone resistance genes (qnrS1).
Genomic epidemiology of nosocomial carbapenemase-producing Citrobacter freundii in sewerage systems in the Helsinki metropolitan area, Finland.
The study identified bla KPC-2 and bla VIM-1 carbapenemase genes, along with various other AMR genes such as aac(6′)-If, aph(6)-Id, aac(3)-IIa, aadA1, dfrA1, sul2, sat2, qnrB, cmlA5, bla OXA-9, bla CMY-79, bla CMY-116, bla TEM-1A, bla CMY-117, bla OXA-10, bla CFE, bla CMY-100, aac(6′)-Ib, aadA2, sul1, qnrS1, qnrB9, mph(E), msr(E), aac(6′)-Iic, and dfrA16 in carbapenemase-producing Citrobacter freundii isolates from hospital environments and municipal wastewater in Finland.
Case report: A successfully treated case of community-acquired urinary tract infection due to Klebsiella aerogenes in Bangladesh.
The study identifies several AMR genes in a multidrug-resistant Klebsiella aerogenes strain, including genes conferring resistance to aminoglycosides, beta-lactams, fluoroquinolones, and others. The strain was found to be susceptible to carbapenems and polymyxins.
Investigation of multidrug-resistant plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates from Pakistan.
The study identified 34 antimicrobial resistance genes (ARGs) in multidrug-resistant (MDR) plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates in Pakistan, including bla NDM-1, bla OXA-48, and various beta-lactamases, aminoglycoside resistance genes, and others.
Dominance of Escherichia coli sequence types ST73, ST95, ST127 and ST131 in Australian urine isolates: a genomic analysis of antimicrobial resistance and virulence linked to F plasmids.
The study identified various antimicrobial resistance genes in E. coli isolates from Australian urine samples, including blaCTX-M-15, blaCTX-M-14, blaTEM-28, sul1, sul2, sul3, dfrA17, dfrA5, dfrA1, dfrB4, tetA, tetB, mphA, cmlA1, cmlA5, catB3, sat2, qnrD1, fosA7, aac(3)-IId, aac(3)-IIe, aph(3')-IIa, aph(6)-Id, ant(3'')-IIa, intI1, and intI2. These genes were associated with resistance to various antibiotics such as beta-lactams, sulfonamides, trimethoprim, tetracycline, macrolides, chloramphenicol, streptothricin, quinolones, fosfomycin, and aminoglycosides.
The impact of applying various de novo assembly and correction tools on the identification of genome characterization, drug resistance, and virulence factors of clinical isolates using ONT sequencing.
The study evaluates the impact of various de novo assembly and read correction tools on the identification of antimicrobial resistance (AMR) genes, plasmids, and virulence factors in clinical Escherichia coli isolates using Oxford Nanopore sequencing. It highlights the effectiveness of Flye and Canu in detecting AMR genes and the importance of read correction tools like Medaka and Racon in improving assembly quality and AMR gene detection.
Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.
The study identified various AMR genes in multidrug-resistant Gram-negative pathogens, highlighting the prevalence of bla CTX-M-15, bla CMY-42, bla NDM-5, aadA, bla TEM-1B, bla OXA-232, bla NDM-1, rmtB, rmtC, bla VEB, bla VIM-2, aph(3'), strA/B, bla OXA-23, aph (3′), catB, dfrB, bla VIM-2, fosA, oqxA, oqxB, bla OXA-23, bla CARB, bla OXA-91, bla OXA-51, bla PAO, bla SHV, aph (3′)-Ib, aph (6)-Id, mphE, msrE, ermB, mphA, aadA, rmtB, qnrB, dfrA, sul1, sul2, and fosA7.
Genomic and functional portrait of multidrug-resistant, hydrogen sulfide (H(2)S)-producing variants of Escherichia coli.
The study identified multidrug-resistant, hydrogen sulfide-producing variants of Escherichia coli from Bangladesh, highlighting the presence of various AMR genes such as bla TEM1B, bla CTX-M-55, bla CTX-M-65, bla CTX-M-123, aadA1, aadA2, aph (3')-Ia, aph (3'')-Ib, aph (6)-Id, tet(A), tet(M), sul3, sul2, dfrA12, mph(A), floR, cmlA1, qacL, and qnrS1.
Genomic and functional portrait of multidrug-resistant, hydrogen sulfide (H(2)S)-producing variants of Escherichia coli.
The study identified multidrug-resistant, hydrogen sulfide-producing variants of Escherichia coli from Bangladesh, highlighting the presence of various AMR genes such as bla TEM1B, bla CTX-M-55, bla CTX-M-65, bla CTX-M-123, aadA1, aadA2, aph (3')-Ia, aph (3'')-Ib, aph (6)-Id, tet(A), tet(M), sul3, sul2, dfrA12, mph(A), floR, cmlA1, qacL, and qnrS1.
Genetic Diversity and Antimicrobial Resistance of Extraintestinal E. coli Populations Pre- and Post-Antimicrobial Therapy on Broilers Affected by Colisepticemia.
The study identified several AMR genes and mutations in extraintestinal E. coli populations from broilers treated with enrofloxacin. Key findings include the presence of qnrB19 and qnrS1 genes, which confer fluoroquinolone resistance, and mutations in gyrA, parC, and parE genes associated with fluoroquinolone resistance. Additionally, multiple other AMR genes were detected, indicating multidrug resistance.
Co-localization of clinically relevant antibiotic- and heavy metal resistance genes on plasmids in Klebsiella pneumoniae from marine bivalves.
The study identifies multiple antibiotic resistance genes (ARGs) and heavy metal resistance genes (HMRGs) co-localized on plasmids in Klebsiella pneumoniae isolated from marine bivalves, highlighting the potential for co-selection of these genes in the marine environment.
Plasmids conferring resistance to extended-spectrum beta-lactamases including a rare IncN+IncR multireplicon carrying bla(CTX-M-1) in Escherichia coli recovered from migrating barnacle geese ( Branta leucopsis).
The study identified several AMR genes in ESBL/AmpC-producing E. coli isolates from barnacle geese, including bla(CTX-M-1), bla(CTX-M-15), bla(CMY-2), aadA2b, lnu(F), and qnrS1, which confer resistance to various beta-lactams, aminoglycosides, lincomycin, and quinolones.
Outbreak of OXA-232-producing carbapenem-resistant Klebsiella pneumoniae ST15 in a Chinese teaching hospital: a molecular epidemiological study.
The study identified the presence of multiple AMR genes, including blaOXA-232, blaCTX-M-15, blaSHV-28, fosA, oqxA, oqxB, tet(E), AAC(6')-Ib, APH(3'')-Ib, APH(6)-Id, TEM-1, sul2, QnrB17, QnrB1, dfrA14, arr-2, AAC(6')-Ib9, and rmtF, in OXA-232-producing CRKP isolates from a hospital outbreak in China.
The origin and evolution of IncF33 plasmids based on large-scale data sets.
The study identifies several clinically important antibiotic resistance genes carried by IncF33 plasmids, including bla CTX-M-55, bla CTX-M-65, fosA3, rmtB, aph(3'')-Ib, aph(6)-Id, aph(3')-IIa, floR, oqxAB, tet(A), and sul2. These genes contribute to multidrug resistance in Enterobacterales, particularly in Escherichia coli, Salmonella, and Klebsiella pneumoniae.
Antibiotic Resistance Mediated by Escherichia coli in Kuwait Marine Environment as Revealed through Genomic Analysis.
The study identified various antibiotic resistance genes in Escherichia coli isolates from Kuwait's marine environment, including beta-lactamases, aminoglycoside-modifying enzymes, fluoroquinolone resistance genes, sulfonamide resistance genes, tetracycline resistance genes, and macrolide resistance genes. Additionally, the MFS-type drug efflux gene mdfA was commonly found in E. coli isolates.
Isolation and Characterization of the Acadevirus Members BigMira and MidiMira Infecting a Highly Pathogenic Proteus mirabilis Strain.
The study identifies multiple antibiotic resistance genes in the highly pathogenic Proteus mirabilis strain MCS, highlighting its multidrug-resistant profile. Key genes include tetA, aac(6')-Iq, aac(6')-Ib', aadA, dfrA1, blaOXA-9, blaCTX-M-2, vat, catA2, sul1, qacEdeltal, tetQ, blaTEM-135, aadA2, aph(3')-Ia, aph(6)-Id, aph(3'')-lb, and sulI.
First Detection and Molecular Characterization of Pseudomonas aeruginosa bla(NDM-1) ST308 in Greece.
The study reports the first detection of blaNDM-1-positive Pseudomonas aeruginosa ST308 in Greece, highlighting the presence of multiple resistance genes including blaNDM-1, blaPAO, blaOXA-10, blaOXA-488, and others, indicating multidrug resistance.
Molecular characterization of highly prevalent Escherichia coli and Escherichia marmotae resistant to extended-spectrum cephalosporins in European starlings (Sturnus vulgaris) in Tunisia.
The study identified several extended-spectrum beta-lactamase (ESBL) and AmpC resistance genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-1, bla CMY-2, and bla CMY-62, in Escherichia coli and Escherichia marmotae isolates from European starlings in Tunisia. Additionally, aminoglycoside resistance genes such as aph(6)-Id and aph(3″)-Ib, along with fosA3, sul1, sul2, sul3, drfA1, drfA17, tet(A), and qnrS1 were also characterized.
The Resistance and Virulence Characteristics of Salmonella Enteritidis Strain Isolated from Patients with Food Poisoning Based on the Whole-Genome Sequencing and Quantitative Proteomic Analysis.
The study identified multiple antimicrobial resistance genes in the multidrug-resistant Salmonella Enteritidis strain 27A, including beta-lactamase blaTEM-194, aminoglycoside resistance genes aac(6)-Ib, aac(6)-If, aph(3”)-Ib, and aph(6)-Id, tetracycline resistance genes tetA, tetR, and tet34, and efflux pump genes acrA, acrB, tolC, oprM, mexE, mexF, macB, mdtG, mdtH, mdtL, mdtM, mdtK, rosA, emrA, emrR, ykkc, and vanRA.
The multidrug-resistant Pseudomonas fluorescens strain: a hidden threat in boar semen preservation.
The study identifies multiple acquired antibiotic resistance genes in the Pseudomonas fluorescens strain GXZC, including those conferring resistance to aminoglycosides, tetracyclines, and sulfonamides. The strain exhibits multidrug resistance and poses a risk in boar semen preservation.
Genomic Analysis of Multidrug-Resistant Escherichia coli Strains Isolated in Tamaulipas, Mexico.
The study identified multiple antimicrobial resistance genes (ARGs) in multidrug-resistant E. coli strains isolated from human clinical, animal, and environmental sources in Tamaulipas, Mexico. These genes include beta-lactamases (bla CTX-M-15, bla OXA-1, bla TEM-1B, bla CMY-2), aminoglycoside resistance genes (aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aadA5, aac3-IIa), sulfonamide resistance genes (sul2, sul3), phenicol resistance gene (catB3), tetracycline resistance genes (tet(A), tet(B)), quaternary ammonium resistance genes (qacE, qacL), macrolide resistance genes (mdfA, mphA), and quinolone resistance gene (qnrB).
The Molecular Characterization of bla(NDM-1)-Positive Acinetobacter baumannii Isolated in Central Greece.
The study identifies multiple AMR genes in blaNDM-1-positive Acinetobacter baumannii isolates, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, macrolide resistance genes, tetracycline resistance genes, trimethoprim resistance genes, and quaternary ammonium resistance genes.
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
Study of heavy metal resistance genes in Escherichia coli isolates from a marine ecosystem with a history of environmental pollution (arsenic, cadmium, copper, and mercury).
The study identified several heavy metal resistance genes (HMRGs) in Escherichia coli isolates from a marine ecosystem with a history of environmental pollution, highlighting the prevalence of these genes and their potential interactions with antibiotic resistance genes.
Resistome and virulome of high-risk pandemic clones of multidrug-resistant extra-intestinal pathogenic Escherichia coli (ExPEC) isolated from tertiary healthcare settings in Uganda.
The study identified various AMR genes in multidrug-resistant E. coli isolates, including blaCTX-M-15, blaTEM-1B, blaOXA-1, and others, which confer resistance to beta-lactams, aminoglycosides, sulfonamides, tetracyclines, macrolides, and quinolones. Additionally, chromosomal mutations in gyrA and parC were found to contribute to fluoroquinolone resistance.
Genomic Diversity, Antimicrobial Resistance, Plasmidome, and Virulence Profiles of Salmonella Isolated from Small Specialty Crop Farms Revealed by Whole-Genome Sequencing.
CRISPR-Cas9-mediated IncF plasmid curing in extraintestinal pathogenic Escherichia coli.
The study identified several AMR genes carried on IncF plasmids in MDR ExPEC strains, including bla TEM-1, aac(3)-IId, tet(A), aph(6)-Id, aph(3')-Ib, mphA, sul1, sul2, aadA5, dfrA17, strAB, qacEdelta1, bla CTX-M-14, bla CTX-M-15, catB3, bla OXA-1, bla CTX-M-27, and aac(6')-Ib-cr5. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, sulfonamides, and chloramphenicol.
Multidrug-resistant Escherichia coli isolated from patients and surrounding hospital environments in Bangladesh: A molecular approach for the determination of pathogenicity and resistance.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from Bangladesh, including bla CTX-M, bla TEM, bla NDM-1, bla OXA, and others, highlighting the prevalence of multidrug resistance in hospital environments and clinical samples.
Genomic characterization of tigecycline-resistant Escherichia coli and Klebsiella pneumoniae isolates from hospital sewage.
The study identifies tet(X4) and tmexCD1-toprJ1 as key genes contributing to tigecycline resistance in E. coli and K. pneumoniae isolates from hospital sewage, highlighting the role of plasmid-mediated resistance and efflux pump overexpression.
Occurrence and temporal distribution of extended-spectrum β-lactamase-producing Escherichia coli in clams from the Central Adriatic, Italy.
The study identified several β-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV12, bla CMY-2, bla TEM-1B, bla TEM-106, and bla TEM-126, which confer resistance to various β-lactam antibiotics. Other resistance genes such as aac(6′)-Ib-cr, qnrS1, tet(A), tet(B), tet(M), aadA5, aadA2b, sul1, sul2, sul3, dfrA17, dfrA5, dfrA14, dfrA12, mph(A), cmlA1, catA2, aac(3)-IIa, aac(3)-IId, and lnu(F) were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates from clams in the Central Adriatic.
Prevalence and genomic characterization of Salmonella isolates from commercial chicken eggs retailed in traditional markets in Ghana.
The study identified several AMR genes and mutations in Salmonella isolates from chicken eggs in Ghana, including aadA1, aph(3")-Ib, aph(6)-Id, catA1, dfrA1, dfrA14, fosA7.2, qnrB19, sul1, sul2, and tet(A), as well as mutations in gyrA (D87N) and gyrA (S83Y).
Molecular epidemiology and pathogenomics of extended-spectrum beta-lactamase producing- Escherichia coli and - Klebsiella pneumoniae isolates from bulk tank milk in Tennessee, USA.
The study identified multiple AMR genes and mutations in ESBL-producing E. coli and K. pneumoniae isolates from bulk tank milk, highlighting the presence of multidrug-resistant strains with resistance to beta-lactams, fluoroquinolones, aminoglycosides, and tetracyclines.
Genetic characterization of a multidrug-resistant Salmonella enterica serovar Agona isolated from a dietary supplement in Germany.
The study identifies 23 antibiotic resistance genes (ARGs) in a multidrug-resistant Salmonella enterica serovar Agona isolate from a dietary supplement in Germany, conferring resistance to 12 different antibiotic classes. Key genes include blaSHV-12, aac(3)-Iig, aac(6')-Iic, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, dfrA19, qacEΔ1, ere(A), sul1, sul2, tet(D), mcr-9.1, catA2, arr, qnrS1, blaTEM-1, aac(3)-IIe, and floR.
Genomic and phenotypic analysis of a novel clinical isolate of Corynebacterium pyruviciproducens.
The study identified several AMR genes in Corynebacterium pyruviciproducens strain WYJY-01, including ermX, aph(3')-Ia, aph(3″)-Ib, aph(6)-Id, and cmx, which confer resistance to macrolide, lincosamide, streptogramin, aminoglycoside, and phenicol antibiotics.
Gut microbiome and antibiotic resistance effects during travelers' diarrhea treatment and prevention.
The study found that twice-daily rifaximin prophylaxis significantly increased antibiotic resistance gene (ARG) abundance in the gut microbiome, while other treatment groups showed no significant changes. Several ARGs, including blaTEM-1, mdtM, sul2, aph(6)-Id, aph(3")-Ib, erm(B), mph(A), qepA4, qnrB19, qnrS1, and arr, were identified in E. coli isolates from the TrEAT TD cohort.
Comparative genomics analysis and characterization of Shiga toxin-producing Escherichia coli O157:H7 strains reveal virulence genes, resistance genes, prophages and plasmids.
Five resistance genes were identified in E. coli O157:H7 strains, including tet(B), sul2, aph(3"-Ib), aph(6)-Id, and mdf(A).
Within-host genetic diversity of extended-spectrum beta-lactamase-producing Enterobacterales in long-term colonized patients.
The study characterizes various AMR genes, including bla CTX-M-15, bla TEM-1B, bla OXA-1, qnrB1, qnrS1, aph(6)-Id, aph(3”)-Ib, aac(3)-IIa, ant(3”)-Ia, dfrA14, dfrA1, aac(6’)-Ib-cr, tet(A), tet(D), sul2, sul1, fosA6, fosA_5, fosA_3, bla CTX-M-1, bla CTX-M-14, bla CTX-M-14b, bla CTX-M-8, bla CMY-2, bla TEM-190, aac(3)-IVa, aph(4)-Ia, and catB3_2, in ESBL-producing Enterobacterales isolates from long-term colonized patients.
Serovars, Virulence and Antimicrobial Resistance Genes of Non-Typhoidal Salmonella Strains from Dairy Systems in Mexico.
Shotgun Metagenomics-Guided Prediction Reveals the Metal Tolerance and Antibiotic Resistance of Microbes in Poly-Extreme Environments in the Danakil Depression, Afar Region.
The study identified numerous antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) in the metagenomes of Lake Afdera and the Assale salt plain in the Danakil Depression. Key ARGs included beta-lactamases (ACC-1, OXA-58, OXA-363, OXA-212, NDM-17, OXA-134, ACT-29, LRA-19), efflux pumps (emrB, abeM, abeS, mgrA, adeJ, MexC, adeL, adeH), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet39, tetX, tetK), and others. MRGs included copper resistance genes (copC, copD), cadmium resistance gene (cadD), mercury resistance gene (merA), chromate resistance genes (chrB, chrA), nickel-cobalt-cadmium resistance genes (nccA, nccB), cobalt-zinc-cadmium resistance gene (czcD), arsenic resistance gene (arsO), lead resistance gene (pbrA), and mercury resistance genes (merB, merR, MIR).
Early-Onset Infection Caused by Escherichia coli Sequence Type 1193 in Late Preterm and Full-Term Neonates.
The study identifies several AMR genes in E. coli ST1193 strains causing early-onset sepsis in neonates, including blaCTX-M-15, blaOXA-1, mph(A), aac(6')-Ib-cr, dfrA17, aph(6)-Id, aac(3)-IIa, aph(3”)-Ib, sul2, catB3, sitABCD, tet(B), and blaTEM-1B, which confer resistance to various antibiotics.
Genomic characterization of Salmonella isolated from retail chicken and humans with diarrhea in Qingdao, China.
The study identified 79 antimicrobial resistance genes (ARGs) in Salmonella isolates from retail chicken and humans with diarrhea in Qingdao, China, including aac(6')-Iaa, bla TEM-1B, tet(A), aph(6)-Id, aph(3")-Ib, sul2, floR, qnrS1, bla NDM-1, mcr-1.1, and mcr-9.1. These genes conferred resistance to various antibiotics such as aminoglycosides, beta-lactams, tetracyclines, sulfonamides, chloramphenicol, fluoroquinolones, carbapenems, and colistin.
Impact of systemic antimicrobial therapy on the faecal microbiome in symptomatic dairy cows.
The study identified AmpC-producing Escherichia coli strains carrying the blaCMY-2 gene, which conferred resistance to third-generation cephalosporins. Other resistance genes such as aph(6)-Id, dfrA14, and sul2 were also detected, providing resistance to streptomycin, trimethoprim, and sulfonamides, respectively.
Metagenomic assembly is the main bottleneck in the identification of mobile genetic elements.
The study evaluated the performance of tools for identifying mobile genetic elements (MGEs) and antimicrobial resistance genes (ARGs) in metagenomic data. It found that metagenomic assembly is the main bottleneck in accurately identifying MGEs and ARGs, with moderate precision and sensitivity for plasmids, phages, IS elements, and ARGs.
Genomic investigation unveils high-risk ESBL producing Enterobacteriaceae within a rural environmental water body.
The study identifies several AMR genes and mutations in ESBL-producing Enterobacteriaceae isolated from a rural environmental water body in India, highlighting the presence of multidrug-resistant strains with genes such as bla VEB-6, bla SHV-12, bla NDM-1, bla CTX-M, and mcr-9, along with mutations in ompK 36 and gyrA.
Genomic Characterization of a Plasmid-Free and Highly Drug-Resistant Salmonella enterica Serovar Indiana Isolate in China.
The study identifies 54 AMR genes and three AMR gene cassettes in the plasmid-free, highly drug-resistant Salmonella enterica serovar Indiana isolate S1467, contributing to resistance against multiple antimicrobial classes.
Genomic insights into ESBL-producing Escherichia coli isolated from non-human primates in the Peruvian Amazon.
The study identified three bla CTX-M variants (bla CTX-M-15, bla CTX-M-55, and bla CTX-M-65) and a broad resistome in ESBL-producing E. coli strains isolated from non-human primates in the Peruvian Amazon.
Clonal and plasmidic dissemination of critical antimicrobial resistance genes through clinically relevant ExPEC and APEC-like lineages (ST) in the dairy cattle population of Québec, Canada.
The study identifies the dissemination of critical AMR genes, including bla CTX-M-15, qnrS1, and bla TEM-1, in E. coli isolates from dairy cattle in Quebec, highlighting the persistence of these genes through plasmids and clones despite reduced antimicrobial use.
Whole-Genome Sequencing of an Escherichia coli ST69 Strain Harboring bla(CTX-M-27) on a Hybrid Plasmid.
The study identifies a multidrug-resistant E. coli ST69 strain carrying the bla(CTX-M-27) gene on a hybrid plasmid, along with various other antibiotic resistance genes such as aminoglycoside, macrolide, sulfonamide, tetracycline, and trimethoprim resistance genes.
Recommendation of a standardized broth microdilution method for antimicrobial susceptibility testing of Avibacterium paragallinarum and resistance monitoring.
The study identified several antimicrobial resistance genes in Avibacterium paragallinarum, including aph(6)-Id, aph(3'')-Ib, bla TEM-1B, catA2, sul2, tet(B), tet(H), and mcr-like, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, sulfonamides, tetracyclines, and polymyxins.
Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021.
The study identified various antimicrobial resistance genes and mutations in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain, highlighting the presence of multidrug-resistant strains and the role of plasmids in the dissemination of resistance mechanisms.
Unveiling distinct genetic features in multidrug-resistant Escherichia coli isolated from mammary tissue and gut of mastitis induced mice.
The study identified multiple antimicrobial resistance genes in multidrug-resistant E. coli strains isolated from mastitis-induced mice, highlighting the complex resistome and potential for horizontal gene transfer.
Characterization of Gallibacterium anatis Isolated from Pathological Processes in Domestic Mammals and Birds in the Czech Republic.
The study identified several AMR genes in Gallibacterium anatis isolates from calves and hens, including aph(3"-Ib, aph(6)-Id, sul2, tet(B), tet(M), bla CARB, and bla ROB. Calf isolates showed a higher incidence of AMR genes compared to hen isolates.
Genomic analysis of Salmonella isolated from canal water in Bangkok, Thailand.
The study identified 35 AMR genes and 30 chromosomal-mediated gene mutations in Salmonella strains from Bangkok canal water, highlighting the presence of multidrug-resistant strains with resistance to various antimicrobial classes.
Comparison of genotypic and phenotypic antimicrobial resistance profiles of Salmonella enterica isolates from poultry diagnostic specimens.
The study identified 31 AMR genes in 97 Salmonella enterica isolates from poultry, including aac(3)-IId, aac(3)-IVa, aac(3)-VIa, aac(6′)-Ib4, ant(2′′)-Ia, grdA, aph(3′)-Ia, aph(3′)-IIa, aadA1, aadA2, aadA7, aadA13, aph(3′)-Ib, aph(6)-Ic, aph(6)-Id, aph(4)-Ia, blaCMY-2, blaCTX-M-1, blaHER-3, blaTEM-1, floR, tetA, tetB, tetC, dfrA12, sul1, sul2, fosA7, qnrB19, ble, and mcr-9.
Predominance of multidrug-resistant Salmonella Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar.
The study identifies multidrug-resistant Salmonella Typhi genotype 4.3.1.1 with low-level ciprofloxacin resistance in Zanzibar, highlighting the presence of resistance genes blaTEM-1B, sul1, sul2, dfrA7, catA1, aph(6)-Id, and aph(3")-Ib, along with gyrA mutations D87G and S83F.
Prevalence and genomic-based antimicrobial resistance analysis of Avibacterium paragallinarum isolates in Guangdong Province, China.
The study identified multiple antimicrobial resistance genes in Avibacterium paragallinarum isolates from Guangdong, China, including tet(B), aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aad-A, sul2, sul3, catP, floR, blaOXA-1, blaCTX-M-14, erm(X), mef(B), and fosA3. These genes were associated with resistance to tetracycline, streptomycin, kanamycin, trimethoprim-sulfamethoxazole, chloramphenicol, ampicillin, erythromycin, and fosfomycin.
Comparison of IncK-bla(CMY-2) Plasmids in Extended-Spectrum Cephalosporin-Resistant Escherichia coli Isolated from Poultry and Humans in Denmark, Finland, and Germany.
The study characterizes IncK-bla(CMY-2) plasmids in extended-spectrum cephalosporin-resistant E. coli isolates from poultry and humans in Denmark, Finland, and Germany, identifying multiple resistance genes including bla(CMY-2), aadA1, aac(3)-Vla, aph(3")-Ib, aph(6)-Id, aac(3)-IId, aadA5, aph(3′)-Ia, sul1, sul2, tet(A), tet(B), and bla TEM-1B.
Antimicrobial Resistance Genes in Respiratory Bacteria from Weaned Dairy Heifers.
The study identified 26 AMR genes in respiratory bacteria from weaned dairy heifers, with high prevalence of tetracycline, aminoglycoside, sulfonamide, beta-lactam, phenicol, and macrolide resistance genes.
Antimicrobial susceptibility and resistome of Actinobacillus pleuropneumoniae in Taiwan: a next-generation sequencing analysis.
The study identified multiple antimicrobial resistance genes in Actinobacillus pleuropneumoniae isolates from Taiwan, including aminoglycoside, tetracycline, beta-lactam, macrolide, and phenicol resistance genes, highlighting the prevalence of multidrug resistance.
Characterization of Escherichia coli pathogenicity and drug resistance in yolk peritonitis.
The study identified multiple drug resistance genes in E. coli isolates from yolk peritonitis cases, including aadA5, APH(3")-Ib, APH(6)-Id, TEM-1, sul1, sul2, parC, gyrA, mfd, kdpE, mphA, and Mrx, which confer resistance to aminoglycosides, beta-lactams, sulfonamides, and fluoroquinolones.
Characterization of Escherichia coli pathogenicity and drug resistance in yolk peritonitis.
The study identified multiple drug resistance genes in E. coli isolates from yolk peritonitis cases, including aadA5, APH(3")-Ib, APH(6)-Id, TEM-1, sul1, sul2, parC, gyrA, mfd, kdpE, mphA, and Mrx, which confer resistance to aminoglycosides, beta-lactams, sulfonamides, and fluoroquinolones.
Genome analyses of colistin-resistant high-risk bla(NDM-5) producing Klebsiella pneumoniae ST147 and Pseudomonas aeruginosa ST235 and ST357 in clinical settings.
The study identifies mgrB deletion and mutations in pmrB, eptA, arnT, eptB, ompA, basS, basR, arnA, cprR, and cprS as key mechanisms of colistin resistance in K. pneumoniae and P. aeruginosa.
Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are genetically related but distinct from those causing prostatic abscesses.
The study identifies multiple AMR genes and mutations in multidrug-resistant E. coli strains causing infections in dogs and cats, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla CMY-2, bla CMY-148, aac(6')-Ib-cr, qnrS1, qnrB6, aadA2, aadA5, aadA16, ant(3′′)-Ia, aph(3′)-Ia, aph(3′′)-Ib, aph(6)-Id, rmtB, floR, cmlA, catA, sul1, sul2, sul3, dfrA12, dfrA14, dfr17, dfrA27, tet(A), tet(B), tet(M), mph(A), erm(B), lnu(F), and arr-3, as well as the gyrA:p.S83L mutation.
Genomic analysis of multidrug-resistant Escherichia coli from Urban Environmental water sources in Accra, Ghana, Provides Insights into public health implications.
The study identified several AMR genes in multidrug-resistant E. coli isolates from urban environmental water sources in Accra, Ghana, highlighting the presence of beta-lactamases (blaTEM-1B, blaCTX-M-15, blaTEM-1C, blaDHA-1, blaOXA-1, blaOXA-181), sulfonamide resistance genes (sul2, sul1), aminoglycoside resistance genes (aph(6)-Id, aadA2, mph(A)), quinolone resistance gene (qnrS1), tetracycline resistance gene (tet(B)), chloramphenicol resistance gene (catA1), dihydrofolate reductase (dfrA14), and others.
Antimicrobial susceptibility profile and molecular characterization of Vibrio parahaemolyticus strains isolated from imported shrimps.
The study identified several AMR genes in V. parahaemolyticus isolates from imported shrimps, including aph(3"-Ib, aph(6)-Id, sul2, tet(59), floR, bla CARB-26, bla CARB-31, bla CARB-41, bla OXA-SHE, and qnrA5, which confer resistance to various antibiotics such as streptomycin, trimethoprim-sulfamethoxazole, tetracycline, chloramphenicol, and others.
Occurrence and genomic characterization of antimicrobial-resistant and potential pathogenic Escherichia coli from Italian artisanal food productions of animal origin.
The study identified multiple antimicrobial resistance (AMR) genes in Escherichia coli isolates from Italian artisanal food products, including beta-lactamases, aminoglycoside-modifying enzymes, trimethoprim resistance genes, macrolide resistance genes, quinolone resistance proteins, sulfonamide resistance proteins, and tetracycline resistance genes. These genes were primarily carried on plasmids and contributed to multidrug resistance.
Identification of genetic markers of resistance to macrolide class antibiotics in Mannheimia haemolytica isolates from a Saskatchewan feedlot.
The study identifies several AMR genes and a ribosomal protein mutation associated with macrolide resistance in Mannheimia haemolytica isolates from a Saskatchewan feedlot.
Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales in Fiji: a multicentre prospective observational study.
The study identified several carbapenem-resistant genes, including bla OXA-23, bla OXA-66, bla NDM-1, bla OXA-50, bla OXA-395, bla NDM-7, and bla NDM-5, in various bacterial species in Fiji.
Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales in Fiji: a multicentre prospective observational study.
The study identified several carbapenem-resistant genes, including bla OXA-23, bla OXA-66, bla NDM-1, bla OXA-50, bla OXA-395, bla NDM-7, and bla NDM-5, in various bacterial species in Fiji.
Genomic characterisation of Escherichia coli isolated from poultry at retail through Sink Surveillance in Dhaka, Bangladesh reveals high levels of multi-drug resistance.
The study identified multiple AMR genes in E. coli isolates from poultry in Bangladesh, including genes conferring resistance to various antibiotics such as tetracycline, ciprofloxacin, azithromycin, colistin, and others. High levels of multidrug resistance were observed, with specific genes like mcr1.1, bla CTX-M-65, and tet(A) playing significant roles.
Salmonella Typhi Haplotype 58 (H58) Biofilm Formation and Genetic Variation in Typhoid Fever Patients with Gallstones in an Endemic Setting in Kenya.
The study identified multidrug resistance genes such as sul1, dfrA7, catA1, aph(6)-Id, aph(3")-Ib, sul2, and blaTEM-1 in S. Typhi isolates from patients with gallstones. Additionally, point mutations in the quinolone resistance determining region (QRDR) of gyrA (S83Y) and gyrB (S464F) were observed, contributing to resistance against ciprofloxacin and nalidixic acid.
Monitoring Changes in the Antimicrobial-Resistance Gene Set (ARG) of Raw Milk and Dairy Products in a Cattle Farm, from Production to Consumption.
The study identified 112 antibiotic-resistance genes in raw milk and dairy products, with a significant increase in resistant genes in aged cheese compared to raw milk. Key genes included OXA-662 and OXA-309, which confer resistance to beta-lactam antibiotics, and several efflux pump genes like abaQ, emrA, and acrAB-tolC, which contribute to fluoroquinolone resistance. The findings highlight the dynamic changes in the resistome during food processing and the potential public health risks associated with the spread of antibiotic resistance genes through raw dairy products.
Correlation analysis of whole genome sequencing of a pathogenic Escherichia coli strain of Inner Mongolian origin.
The study identified 127 antibiotic resistance genes in the E. coli strain E12, including genes for beta-lactamases, aminoglycoside modifying enzymes, sulfonamide resistance, and efflux pumps, indicating a high level of multidrug resistance.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
The IncC and IncX1 resistance plasmids present in multi-drug resistant Escherichia coli strains isolated from poultry manure in Poland.
The study identifies three resistance plasmids (pECmdr13.2, pECmdr13.3, pECmdr14.1) in multi-drug resistant E. coli strains from poultry manure in Poland, each carrying various AMR genes including tetracycline, aminoglycoside, beta-lactam, sulfonamide, fluoroquinolone, and phenicol resistance genes.
A newly identified IncY plasmid from multi-drug-resistant Escherichia coli isolated from dairy cattle feces in Poland.
The study identifies two IncY plasmids from multi-drug-resistant E. coli isolated from dairy cattle feces in Poland, carrying resistance genes against beta-lactams, aminoglycosides, tetracyclines, trimethoprim/sulfamethoxazole, and fluoroquinolones.
Salmonella Typhi genotypic diversity, cluster identification and antimicrobial resistance determinants in Mukuru settlement, Nairobi Kenya.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella Typhi isolates from Mukuru settlement, Nairobi, Kenya, highlighting the prevalence of multidrug-resistant strains.
Mobile genetic elements define the non-random structure of the Salmonella enterica serovar Typhi pangenome.
The study identifies multiple AMR genes, including blaTEM-1B, qnrS1, sul2, tet(A), aph(3'')-Ib, aph(6)-Id, dfrA14, blaCTX-M-15, blaCTX-M-88, catA1, qacE, sul1, and tet(B), which are associated with multidrug-resistant and extensively drug-resistant Salmonella enterica serovar Typhi strains.
Host species shapes genotype, antimicrobial resistance, and virulence profiles of enterotoxigenic Escherichia coli (ETEC) from livestock in the United States.
The study identifies distinct antimicrobial resistance (AMR) gene profiles in bovine and swine enterotoxigenic Escherichia coli (ETEC) isolates, highlighting differences in the prevalence of specific AMR genes and plasmid replicons between the two host species.
Genomic Evaluation of Multidrug-Resistant Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli from Irrigation Water and Fresh Produce in South Africa: A Cross-Sectional Analysis.
The study identified several AMR genes in multidrug-resistant ESBL-producing E. coli isolates from irrigation water and fresh produce in South Africa, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, aph(6)-Id, ant(3″)-Ia, aadA2, aph(3″)-Ib, sul2, sul3, dfrA1, fosA3, cmlA1, and floR.
Bacterial Genomics for National Antimicrobial Resistance Surveillance in Cambodia.
The study identified various AMR genes and mutations in bacterial isolates from Cambodia, including extended-spectrum beta-lactamase genes (blaCTX-M-15, blaCTX-M-27, blaCTX-M-55), carbapenemase genes (blaOXA-23, blaNDM-1, blaOXA-58, blaOXA-66), and colistin resistance genes (mcr-1, mcr-3, mcr-7, mcr-9). Additionally, mutations in gyrA (S83F) and parC (S84L) were found to confer fluoroquinolone resistance in Salmonella enterica serovars Paratyphi A and Typhi.
Carriage Rate of Enterobacterales Resistant to Extended-Spectrum Cephalosporins in the Tunisian Population.
The study identified bla CTX-M-15 and bla DHA-1 as the primary genes conferring resistance to extended-spectrum cephalosporins in Enterobacterales isolated from healthy Tunisian individuals. Additional resistance mechanisms included aminoglycoside, sulfonamide, tetracycline, and quinolone resistance genes.
Phylogenetics and Mobilization of Genomic Traits of Cephalosporin-Resistant Escherichia coli Originated from Retail Meat.
The study identified multiple AMR genes in cephalosporin-resistant E. coli from retail meat, including bla CTX-M-1, bla SHV-12, bla CMY-2, and others, highlighting the role of mobile genetic elements in the spread of resistance.
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape.
The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.
The ISVsa3-ORF2-abh-tet(X4) circular intermediate-mediated transmission of tigecycline resistance in Escherichia coli isolates from duck farms.
The study identifies the tet(X4) gene in E. coli isolates from duck farms, demonstrating its presence in a circular intermediate and its ability to transfer via conjugation, highlighting the potential for widespread tigecycline resistance.
Antibiotic Resistance Genes and Plasmid Characteristics in Enterobacteriaceae Isolated from Fresh Produce
The study identified several antibiotic resistance genes on plasmids and chromosomes of Enterobacteriaceae strains isolated from fresh produce, highlighting the diversity of resistance mechanisms and the potential for horizontal gene transfer.
Whole-genome sequencing of two multidrug-resistant acinetobacter baumannii strains isolated from a neonatal intensive care unit in Egypt: a prospective cross-sectional study.
The study identified multidrug-resistant Acinetobacter baumannii strains from a neonatal ICU in Egypt, highlighting the presence of various beta-lactamase genes, aminoglycoside resistance genes, macrolide resistance genes, tetracycline resistance genes, and sulfonamide resistance genes.
Genomic Characterization of Extended-Spectrum β-Lactamase-Producing and Third-Generation Cephalosporin-Resistant Escherichia coli Isolated from Stools of Primary Healthcare Patients in Ethiopia.
The study identified multiple antimicrobial resistance genes in E. coli isolates, including bla CTX-M-15, bla TEM-1B, tet(A), qnrS1, and others, highlighting the prevalence of multidrug resistance in the region.
Comprehensive Genomic Analysis of Uropathogenic E. coli: Virulence Factors, Antimicrobial Resistance, and Mobile Genetic Elements.
The study identified numerous antimicrobial resistance genes and mutations in uropathogenic E. coli isolates, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and quinolone resistance genes. Mutations in gyrA, parC, parE, and marR were associated with fluoroquinolone resistance, while mutations in PmrB, CyaA, GlpT, PtsI, and UhpT were linked to fosfomycin resistance.
Environmental contamination with carbapenem resistant Acinetobacter baumannii in healthcare settings in Fiji: a potential source of infection.
The study identified several carbapenem-resistant Acinetobacter baumannii (CR Ab) isolates from high-touch surfaces in Fijian hospitals, revealing the presence of resistance genes such as bla OXA-23, bla NDM-1, and others, along with mutations in genes like parC and gyrA, contributing to resistance against multiple antibiotics.
First report of carbapenems encoding multidrug-resistant gram-negative bacteria from a pediatric hospital in Gaza Strip, Palestine.
The study identified multiple carbapenem resistance genes, including bla KPC-2, bla PDC-36/12, and bla POM-1, in multidrug-resistant Gram-negative bacteria isolated from a pediatric hospital in the Gaza Strip. These genes were found in various bacterial species such as Escherichia coli and Klebsiella pneumoniae.
Contribution of the Mobilome to the Configuration of the Resistome of Corynebacterium striatum.
The study identified 20 antimicrobial resistance genes in Corynebacterium striatum, with ErmX being the most prevalent. These genes are mainly associated with plasmid sequence regions and class 1 integrons, highlighting the role of mobile genetic elements in the dissemination of resistance.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Analysis of Acinetobacter P-type type IV secretion system-encoding plasmid diversity uncovers extensive secretion system conservation and diverse antibiotic resistance determinants.
This study identified 17 distinct antibiotic resistance genes across 53 P-type T4SS-encoding plasmids in Acinetobacter species, including various beta-lactamases, aminoglycoside modifying enzymes, and others, highlighting the significant diversity of resistance determinants carried by these plasmids.
Microplastic diversity increases the abundance of antibiotic resistance genes in soil.
The study shows that increasing microplastic diversity in soil leads to a significant increase in the abundance of antibiotic resistance genes (ARGs), including those conferring resistance to aminoglycosides, macrolide-lincosamide-streptogramin, florfenicol, and tetracycline.
Neural network-based predictions of antimicrobial resistance phenotypes in multidrug-resistant Acinetobacter baumannii from whole genome sequencing and gene expression.
The study presents a deep neural network model capable of predicting antimicrobial resistance phenotypes in multidrug-resistant Acinetobacter baumannii using whole genome sequencing and gene expression data. The model achieves high accuracy in predicting resistance to various antibiotics, including β-lactams, aminoglycosides, and carbapenems.
Florfenicol administration in piglets co-selects for multiple antimicrobial resistance genes.
Florfenicol administration in piglets leads to the selection of multiple antimicrobial resistance genes, including those conferring resistance to phenicols, aminoglycosides, beta-lactams, sulfonamides, and oxazolidinones.
Comparative genomics analysis of Salmonella Enteritidis isolated from clinical cases associated with chicken.
Five Salmonella Enteritidis isolates were analyzed, revealing multiple antimicrobial resistance genes and chromosomal mutations. Key resistance genes included bla CTX−M−55, bla TEM−141, bla TEM−1B, aac(6')-Iaa, aph(3’)-IIa, aph(3’’)-Ib, aph(6)-Id, tet(A), floR, fosA3, and sul2. Chromosomal mutations in gyrA (D87G/D87Y) and acrB (F28L/L40P) were also identified, contributing to fluoroquinolone and multidrug resistance.
Antimicrobial resistance, virulence factors and phylogenetic profiles of Vibrio parahaemolyticus in the eastern coast of Shenzhen.
The study identified several antimicrobial resistance genes in Vibrio parahaemolyticus isolates from Shenzhen, including blaCARB, tet(34), tet(35), qnrVC6, sul2, aph(6)-Id, floR, cat, and blaCTX-M-14. These genes conferred resistance to various antibiotics such as ampicillin, tetracycline, fluoroquinolones, sulfonamides, aminoglycosides, chloramphenicol, and beta-lactams.
Multidrug-resistant ESBL-producing Klebsiella pneumoniae complex in Czech hospitals, wastewaters and surface waters.
The study identified multidrug-resistant Klebsiella pneumoniae complex isolates carrying various beta-lactamase genes such as bla CTX-M-15, bla GES-51, bla OXA-48, bla NDM-1, and bla KPC-3, along with other resistance genes like oqxA, oqxB, sul2, aph(6)-Id, dfr14, qnrB1, and aac(6')-Ib-cr.
Salmonella Typhi Haplotype 58 biofilm formation and genetic variation in isolates from typhoid fever patients with gallstones in an endemic setting in Kenya.
The study identified multidrug resistance genes sul1, dfrA7, catA1, aph(6)-Id, aph(3" )-Ib, sul2, and blaTEM-1 in S. Typhi isolates from household D, along with specific mutations in the quinolone resistance-determining region (QRDR) of gyrA and gyrB. Additionally, missense mutations in the treB and tviE genes were observed in isolates from different households.
Microbial spectrum and resistance of odontogenic abscesses - microbiological analysis using next generation sequencing.
The study identified multiple AMR genes in odontogenic abscesses using NGS, including genes conferring resistance to tetracyclines, macrolides, lincosamides, aminoglycosides, chloramphenicol, sulfonamides, penicillins, and others. Notably, Fusobacterium showed resistance to clindamycin.
Genomic and virulent characterization of a duck-associated Salmonella serovar Potsdam from China.
The study identified several antimicrobial resistance genes and mutations in Salmonella serovar Potsdam isolated from duck embryos, including aac(3')-Ia, aac(4')-IIa, aph(3')-IIa, aph(3')'-Ib, aph(6')-Id, blaTEM-116, blaTEM-1B, and tet(A), as well as gyrA and parC mutations associated with quinolone resistance.
Fecal carriage of ESBL-producing E. coli and genetic characterization in rural children and livestock in the Somali region, Ethiopia: a one health approach.
The study identified bla CTX-M-15 as the most prevalent ESBL gene in both human and animal E. coli isolates, along with other resistance genes such as bla TEM-1B, bla OXA-1, and various aminoglycoside, sulfonamide, and trimethoprim resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Genomic insights into drug resistance and virulence determinants in rare pyomelanin-producing clinical isolates of Acinetobacter baumannii.
The study identifies several AMR genes including blaOXA-23, blaADC-25, aph(3')-VIa, armA, aph(6)-Id, tet(B), and msr(E) in pyomelanin-producing Acinetobacter baumannii isolates, highlighting their multidrug-resistant profile.
Molecular Epidemiology and Genetic Characterization of Carbapenem-Resistant Acinetobacter baumannii Isolates from the ICU of a Tertiary Hospital in East China.
The study identified 48 antimicrobial resistance genes (ARGs) in 39 carbapenem-resistant Acinetobacter baumannii (CRAB) isolates, including blaOXA-66, blaOXA-23, blaADC-30, blaADC-73, gyrA, ant(3")-IIa, aph(3")-Ib, aph(6)-Id, tetB, tetR, sul1, sul2, LpsB, LpxC, and LpxA, which confer resistance to various antibiotics such as carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, tetracycline, and sulfonamides.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Can α-Mangostin and Photodynamic Therapy Support Ciprofloxacin in the Inactivation of Uropathogenic Escherichia coli and Staphylococcus aureus Strains?
The study identified several antibiotic resistance genes in clinical strains of Staphylococcus aureus and Escherichia coli, including blaZ, grlA, grlB, gyrA, mecA, ermC, aph(6)-Id, aph(3")-Ib, aadA5, blaCTX-M-27, mph(A), sul1, sul2, tet(A), and dfrA17. These genes confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, aminoglycosides, sulfonamides, tetracyclines, and macrolides.
Pandemic one health clones of Escherichia coli and Klebsiella pneumoniae producing CTX-M-14, CTX-M-27, CTX-M-55 and CTX-M-65 ESβLs among companion animals in northern Ecuador.
The study identifies CTX-M-55, CTX-M-65, CTX-M-27, and CTX-M-14 ESβL-producing E. coli and K. pneumoniae in companion animals in Ecuador, highlighting their global One Health significance and the need for surveillance programs.
Molecular Epidemiology and In-Depth Characterization of Klebsiella pneumoniae Clinical Isolates from Armenia.
The study identifies multiple AMR genes and mutations in K. pneumoniae isolates from Armenia, highlighting the presence of XDR and MDR strains with resistance to various antibiotics, including carbapenems, aminoglycosides, and quinolones.
Assessment of Antibiotic Resistance Among Isolates of Klebsiella spp. and Raoultella spp. in Wildlife and Their Environment from Portugal: A Positive Epidemiologic Outcome.
The study identified a single multidrug-resistant (MDR) and extended-spectrum beta-lactamase (ESBL)-producing K. pneumoniae isolate from soil samples carrying multiple resistance genes, including bla CTX-M-15, bla TEM-1, bla SHV-28, bla OXA-1, qnr B1, oqx A, oqx B19, aac (6′)-Ibcr, sul 2, dfr A14, tet A, aph (6)-Id, aph (3″)-Ib, acr D, cat B3, and Int I1.
Essential oils modulate virulence phenotypes in a multidrug-resistant pyomelanogenic Pseudomonas aeruginosa clinical isolate.
The study identifies multiple AMR genes in the MDR P. aeruginosa strain U804, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, which contribute to its resistance against various antibiotics.
Capture of mobile genetic elements following intercellular conjugation promotes the production of ST11-KL64 CR-hvKP.
The study characterizes the AMR genes and mutations involved in the conjugation process between hvKP and CRKP strains, highlighting the role of mobile genetic elements in the emergence of ST11-KL64 CR-hvKP strains.
Whole-genome sequencing of Acinetobacter baumannii clinical isolates from a tertiary hospital in Terengganu, Malaysia (2011-2020), revealed the predominance of the Global Clone 2 lineage.
The study identified the predominance of the Global Clone 2 lineage of Acinetobacter baumannii in Terengganu, Malaysia, with a focus on the detection of various antimicrobial resistance genes, including bla OXA-23, bla ADC, bla NDM-1, and others, contributing to multidrug resistance.
Bayesian phylogeographic analysis infers cross-border transmission dynamics of drug-resistant Salmonella Enteritidis.
The study identifies multiple antimicrobial resistance genes in Salmonella Enteritidis isolates from various regions, highlighting the cross-border transmission of drug-resistant strains and the significance of international food trade in spreading antimicrobial resistance.
Tracing the evolution: the rise of Salmonella Thompson co-resistant to clinically important antibiotics in China, 1997-2020.
The study identifies the IncC plasmid as a major driver of co-resistance to ciprofloxacin, cefotaxime, and azithromycin in Salmonella Thompson isolates in China, with specific resistance genes including qnrS1, qepA4, blaCMY-2, and mph(A).
Genomic epidemiology and antimicrobial resistance of Morganella clinical isolates between 2016 and 2023.
The study identified several AMR genes in Morganella clinical isolates, including tet(B), sul1, catA2, sul2, floR, aadA1, and others, contributing to resistance against various antibiotics.
Genomic insights into plasmid mediated AMR genes, virulence factors and mobile genetic elements in raw milk Escherichia coli from Gujarat, India.
The study identified multiple antibiotic resistance genes in E. coli isolates from raw milk in Gujarat, India, including beta-lactamases, quinolone resistance genes, efflux pumps, folate pathway antagonists, aminoglycoside resistance genes, and tetracycline resistance genes.
Genomic insights into plasmid mediated AMR genes, virulence factors and mobile genetic elements in raw milk Escherichia coli from Gujarat, India.
The study identified multiple antibiotic resistance genes in E. coli isolates from raw milk in Gujarat, India, including beta-lactamases, quinolone resistance genes, efflux pumps, folate pathway antagonists, aminoglycoside resistance genes, and tetracycline resistance genes.
Genotypic and phenotypic analyses of two distinct sets of Pseudomonas aeruginosa urinary tract isolates.
The study identified multiple AMR genes and mutations in P. aeruginosa UTI isolates from the UK and Kuwait, highlighting the presence of multidrug-resistant strains, especially in Kuwaiti isolates. Key AMR genes included aac(3)-IV, aph(3')-Ib, aph(3')-IIb, aph(4)-Ia, aph(6)-Id, crpP, dfrB1, aac(6')-Ib7, aac(6')-ii, aaA61, blaPDC, and blaVIM-28. Mutations in gyrA were also found to contribute to fluoroquinolone resistance.
Detection of a genetically related carbapenemase-producing Escherichia coli ST167 in clinical and environmental isolates: Evidence for clonal spread of carbapenemase-producing Enterobacteriaceae in humans and the environment in Iowa, United States.
The study identifies a carbapenemase-producing E. coli strain BO1 carrying bla NDM-5, along with other resistance genes, highlighting the clonal spread of carbapenemase-producing Enterobacteriaceae between humans and the environment in Iowa.
Integrative and conjugative elements associated with antimicrobial resistance in multidrug resistant Pasteurella multocida isolates from bovine respiratory disease (BRD)-affected animals in Spanish feedlots.
The study identified multiple antimicrobial resistance genes and mutations in multidrug-resistant Pasteurella multocida isolates from bovine respiratory disease-affected animals in Spanish feedlots, highlighting the role of mobile genetic elements in the spread of resistance.
Whole-genome sequencing-based species classification, multilocus sequence typing, and antibiotic resistance mechanisms of the clinical Aeromonas complex.
The study identified multiple beta-lactamase genes, including bla NDM-1, bla PER-3, and bla OXA-1, along with other resistance genes such as aac(6′)-Ib-cr6, aph(3″)-Ib, and floR, which contribute to resistance against various antibiotics in Aeromonas isolates.
Broiler litter moisture and trace metals contribute to the persistence of Salmonella strains that harbor large plasmids carrying siderophores.
The study identified several antimicrobial resistance genes in Salmonella strains isolated from broiler litter, including aadA1, aac(3)-IV, aph(3′)-Ia, aph(4)-Ia, dfrA14, floR, sul1, tetA, sul2, merRTPCA, qacE, aph(3″)-Ib, aph(6)-Id, pcoABCDRE, silP, and silE. These genes were found on various plasmids and contributed to resistance against multiple antibiotics such as streptomycin, chloramphenicol, sulfamethoxazole, tetracycline, mercury, quaternary ammonium compounds, copper, and silver.
Whole-Genome Sequencing of Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Isolated from Human Bloodstream Infections.
The study identified multiple AMR genes in ESBL-producing K. pneumoniae isolates, including blaCTX-M-15, blaKPC-3, and others conferring resistance to β-lactams, aminoglycosides, fluoroquinolones, sulfonamides, tetracyclines, and chloramphenicol.
Zoonotic potential of uropathogenic Escherichia coli lineages from companion animals.
The study identified several antimicrobial resistance genes in uropathogenic E. coli strains from companion animals, including blaTEM-1b, sul1, sul2, dfrA1_10, dfrA17_1, dfrA1_8, dfrA7_5, gyrA_S83L, tetA, tetB, aph(6)-Id, aph(3'')-Ib, ant(3'')-Ia, blaCTX-M-15, blaTEM-106, blaSHV-102, and blaCMY-2. These genes confer resistance to various antibiotics such as penicillins, sulfonamides, trimethoprim, quinolones, tetracyclines, streptomycin, and cephalosporins.
Polyclonal carbapenemase-producing Escherichia coli in Northern Italy: the emergence of NDM-7.
The study identifies the emergence of NDM-7 in polyclonal carbapenemase-producing E. coli in Northern Italy, highlighting the presence of various carbapenemase genes such as bla KPC-3, bla VIM-1, and bla NDM-7, along with other resistance genes.
Comprehensive molecular epidemiology of Acinetobacter baumannii from diverse sources in Nigeria.
The study identified 168 AMR genes in 189 Nigerian A. baumannii isolates, including blaADC-79, blaOXA-23, aph(3")-Ib, and others, highlighting the widespread presence of multidrug resistance.
Genomic characterization of extended-spectrum β-lactamase-producing Escherichia coli spread among chickens and healthy residents in Lombok, Indonesia.
The study identifies bla CTX-M-55, bla CTX-M-15, bla CTX-M-1, bla CMY-2, and bla DHA-1 as the most prevalent extended-spectrum β-lactamase genes in E. coli isolates from chickens and humans in Lombok, Indonesia. Additionally, the study characterizes a 200 kb IncHI1 plasmid carrying multiple resistance genes, including aac(3)-IId, aph(6)-Id, aph(3’’)-Ib, aadA17, mph(A), Inu(F), qnrS1, sul2, and dfrA14, contributing to multidrug resistance.
Inhibitory effects of benzyl isothiocyanate on widespread mcr-1-harbouring IncX4 plasmid transfer.
The study characterizes the presence of mcr-1.1, mcr-3.5, blaCTX-M-55, and tet(X4) genes in clinical isolates of Enterobacterales from Thailand, highlighting their role in multidrug resistance and the potential for horizontal gene transfer.
Genetic diversity of Salmonella enterica during acute human infections.
The study identifies variations in antibiotic resistance gene (ARG) carriage among same-patient Salmonella isolates, particularly highlighting the presence of APH(6)-Id and APH(3")-lb genes associated with streptomycin resistance.
Differences in antimicrobial resistance between exoU and exoS isolates of Pseudomonas aeruginosa.
ExoU isolates of Pseudomonas aeruginosa exhibited higher resistance to fluoroquinolones and aminoglycosides compared to exoS isolates, primarily due to mutations in gyrA, parC, and efflux pump-related genes, as well as the presence of acquired resistance genes aph(3''-Ib) and aph(6)-Id.
Genomic epidemiology of Salmonella Enteritidis human infections in the Netherlands, 2019 to 2023.
The study identified several AMR genes and mutations in Salmonella Enteritidis isolates from the Netherlands, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and quinolone resistance proteins, as well as specific gyrA mutations associated with (fluor)quinolone resistance.
Genome-Based Molecular Diversity of Extended-Spectrum β-Lactamase-Producing Escherichia coli From Pigeons in China.
The study identifies multiple extended-spectrum β-lactamase (ESBL) genes, including bla CTX-M, bla TEM, bla OXA, bla LAP, and bla CMY, as well as other antibiotic resistance genes such as mcr-1, mcr-1.1, tet(X4), aadA1, aadA2, aph(6)-Id, aph(3")-Ib, aph(3')-Ia, aph(3')-IIa, aac(3)-IVa, aph(4)-Ia, tet(A), tet(M), sul2, sul3, dfrA14, qnrS1, arr-2, fosA3, cmlA5, floR, mph(A), and lnu(F) in ESBL-producing E. coli isolates from pigeons in China.
Contaminated drinking water facilitates Escherichia coli strain-sharing within households in urban informal settlements.
The study identified several clinically relevant antibiotic resistance genes (ARGs) in Escherichia coli strains from various sources, including poultry, humans, dogs, soil, and stored drinking water. Notably, bla TEM-1 and bla CTX-M-15 were widely detected, indicating the spread of beta-lactam resistance. Additionally, aph(6)-Id, which confers aminoglycoside resistance, was commonly found in canine samples.
Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?
The study identified multiple antibiotic resistance genes in clinical Klebsiella pneumoniae isolates, including bla TEM, bla SHV, bla CTX-M, and bla OXA families, as well as aminoglycoside, fluoroquinolone, and sulfonamide resistance genes. Effluent isolates showed fewer resistance genes and lower resistance levels compared to clinical isolates.
A decade of genomic and phenotypic adaptation of carbapenem-resistant Acinetobacter baumannii.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii isolates, including blaOXA-23, blaOXA-51-like, and several aminoglycoside resistance genes, contributing to extensive drug resistance.
Antimicrobial Resistance in Nigeria: A Comprehensive Review of Environmental, Food, and Clinical Impacts
The study identifies several AMR genes, including bla CTX-M-15, floR, and various tetracycline and sulfonamide resistance genes, highlighting the spread of multidrug-resistant bacteria in Nigeria's environment, food supply chain, and clinical settings.
Molecular characterization of multidrug-resistant E. coli recovered from diarrheagenic children under 5 years from Mukuru Informal Settlement, Nairobi, Kenya, based on whole-genome sequencing analysis.
The study identified multiple AMR genes and mutations in multidrug-resistant E. coli isolates from diarrheagenic children in Nairobi, Kenya, highlighting the presence of blaTEM-1B, blaCTX-M-15, qnrS1, qnrB4, aac(6')-Ib-cr, and other resistance mechanisms.
Rapid whole genome sequencing for AMR surveillance in low- and middle-income countries: Oxford Nanopore Technology reveals multidrug-resistant Enterobacter cloacae complex from dairy farms in Sri Lanka.
The study identified multiple AMR genes in multidrug-resistant Enterobacter isolates from dairy farms in Sri Lanka, including blaCMH-1, blaACT-25, blaCTX-M-15, blaOXA-1, blaTEM-1, blaNDM-4, and blaNDM-15, highlighting the presence of carbapenem-resistant Enterobacterales and the need for improved AMR surveillance in low-resource settings.
Rapid whole genome sequencing for AMR surveillance in low- and middle-income countries: Oxford Nanopore Technology reveals multidrug-resistant Enterobacter cloacae complex from dairy farms in Sri Lanka.
The study identified multiple AMR genes in multidrug-resistant Enterobacter isolates from dairy farms in Sri Lanka, including blaCMH-1, blaACT-25, blaCTX-M-15, blaOXA-1, blaTEM-1, blaNDM-4, and blaNDM-15, highlighting the presence of carbapenem-resistant Enterobacterales and the need for improved AMR surveillance in low-resource settings.
Highly carbapenem-resistant Achromobacter xylosoxidans harboring bla(NDM-1) in Myanmar.
The study identifies bla(NDM-1), bla(OXA-114), and bla(PSE-1) as carbapenem resistance genes in Achromobacter xylosoxidans isolates from Myanmar, along with aminoglycoside modifying enzymes such as aac(6')-Ib, aph(6)-Id, aph(3'')-Ib, ant(4')-Iib, and aph(3')-VI.
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
The study identified multiple antibiotic resistance genes and mutations in E. coli isolates from intensive pig farming in South Africa, highlighting the spread of resistance across the pork production continuum.
Clonal dissemination and persistence of Carbapenem-resistant bla (KPC-2) harbouring Klebsiella pneumoniae ST307 in a Tertiary Hospital in the Republic of Korea.
Integrated genomic-epigenomic-transcriptomic analyses reveal adaptive mechanisms of colistin and carbapenem resistance in Klebsiella pneumoniae and Enterobacter isolates
The study identifies multiple AMR genes and mutations associated with colistin and carbapenem resistance in Klebsiella pneumoniae and Enterobacter isolates, including beta-lactamases, fosfomycin resistance genes, and efflux pumps. Mutations in ompK35 were found to contribute to carbapenem resistance.
Local Genomic Epidemiology of Acinetobacter baumannii Circulating in Hospital and Non-hospital Environments in Kano, Northwest Nigeria.
The study identifies various AMR genes in Acinetobacter baumannii isolates from hospital and non-hospital environments in Kano, Nigeria, including bla OXA-66, bla OXA-180, bla ADC-25, aadA1, aph(3')-Ia, aph(3'' )-Ib, aac(3)-Ia, aph(6)-Id, tetB, sul1, and sul2, which confer resistance to beta-lactams, aminoglycosides, tetracyclines, and sulfonamides.
Genomic insights into antimicrobial resistance and virulence of E. coli in central Ethiopia: a one health approach.
The study identified multiple antimicrobial resistance genes (ARGs) in E. coli isolates from central Ethiopia, including bla-ampH, bla-AmpC1, tet(A), mdf(A), aph(3")-Ib, sul2, and aph(6)-Id. Chromosomal mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Characterization of the Diversity in Host Range of an Extensively Drug-Resistant (XDR) Type IV Secretion System-Encoding Plasmid in Acinetobacter.
The study characterizes the XDR plasmid p1AB5075, which harbors multiple antibiotic resistance genes, including blaGES-11, aac(6')-Ib10, ant(2")-Ia, aadA2, aph(3")-Ib, aph(6)-Id, cmlA1, dfrA7, sul1, and qacEΔ1, conferring resistance to various antibiotics such as beta-lactams, aminoglycosides, chloramphenicol, trimethoprim, and sulfonamides. The plasmid was successfully transferred to genetically diverse Acinetobacter strains, highlighting its potential for spreading resistance.
Multidrug-resistant Klebsiella pneumoniae ST70 harboring bla(NDM) in a migratory Penguin.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Klebsiella pneumoniae ST70 isolate from a Magellanic Penguin, highlighting the potential of migratory penguins as vectors of antimicrobial-resistant microorganisms.
Variants of β-lactamase-encoding genes are disseminated by multiple genetically distinct lineages of bloodstream Escherichia coli.
The study identified multiple β-lactamase genes, including bla TEM-1, bla CTX-M-15, and bla OXA-1, along with other AMR genes such as aadA5, aph(3")-Ib, aph(6)-Id, mphA, sul1, sul2, tetA, dfrA17, and aac(6')-Ib-cr5, which confer resistance to various antimicrobial classes in bloodstream E. coli isolates.
Genomic insights into multidrug - resistant Salmonella enterica isolates from pet dogs and cats.
The study identified multiple AMR genes in multidrug-resistant Salmonella enterica isolates from pet dogs and cats, including aac(6')-Iaa, aadA1, aadA2, blaTEM-1B, qacL, sul3, tet(A), qnrS1, fosA7, dfrA12, cmlA1, aph(3')-Ib, aph(6)-Id, blaCTX-M-55, blaTEM-215, and floR, which confer resistance to various antibiotics such as ampicillin, tetracycline, sulfamethoxazole, ciprofloxacin, and chloramphenicol.
Acquired antibiotic resistance of Pseudomonas spp., Escherichia coli and Acinetobacter spp. in the Western Balkans and Hungary with a One Health outlook.
The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.
Acquired antibiotic resistance of Pseudomonas spp., Escherichia coli and Acinetobacter spp. in the Western Balkans and Hungary with a One Health outlook.
The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica.
The study identified several AMR genes in E. coli isolates from two sloth species in Costa Rica, including blaTEM-1B, aph(3')-Id, aph(6)-Id, tet(A), tet(B), sul2, qnrS1, floR, and dfrA8, which were associated with resistance to various antibiotics.
Taxonomic and phenotypic characterization of a novel Providencia species: Providencia lanzhouensis sp. nov.
The study identifies Providencia lanzhouensis sp. nov., a novel species with multiple antimicrobial resistance genes, including aadA1, aadA2, aph(6)-Id, aph(3'')-Ib, aph(3')-Ia, sat2, sul2, ere(A), dfrA32, floR, tetC, and qnrD1, which confer resistance to aminoglycosides, streptomycin, sulfonamides, macrolides, trimethoprim, phenicols, tetracyclines, and quinolones.
Antimicrobial resistance and biofilm formation in rarely reported Salmonella enterica serovars from patients presenting with gastroenteritis in Nairobi, Kenya.
Three Salmonella Newport isolates carried acquired antimicrobial resistance genes, including bla TEM −1 , tet(A), aph(6)-Id, dfrA14, and sul2. These genes conferred resistance to ampicillin, tetracycline, trimethoprim-sulfamethoxazole, and gentamicin.
Plasmid diversity in Klebsiella pneumoniae ST307 co-producing KPC plus NDM recovered during the COVID-19 pandemic.
The study characterizes the plasmid diversity in Klebsiella pneumoniae ST307 isolates co-producing KPC and NDM carbapenemases, identifying multiple resistance genes and plasmid types involved in carbapenem resistance.
Antimicrobial resistance and virulence gene profiles of Escherichia coli isolated from poultry farms using One Health perspective in Abeokuta, Nigeria.
The study identified 30 different resistance determinants in 14 whole genome sequenced E. coli isolates from poultry farms in Abeokuta, Nigeria. These included genes such as blaTEM-1B, blaCARB-2, aph(3'')-Ib, aph(6)-Id, floR, sul1, sul2, tet(A), and tet(B), among others, which conferred resistance to various antimicrobial classes.
Genomic Characterization and Antibiotic Resistance Profiles of Acinetobacter baumannii Isolates From Intensive Care Units in Vietnam.
The study identifies multiple AMR genes in three CRAB isolates, including blaOXA-23, blaOXA-66, blaADC-198, blaADC-73, and various aminoglycoside modifying enzymes, efflux pumps, and sulfonamide resistance genes, highlighting the extensive multidrug resistance in these isolates.
Population Structure, Genomic Features, and Antibiotic Resistance of Avian Pathogenic Escherichia coli in Shandong Province and Adjacent Regions, China (2008-2023).
The study identified multiple antibiotic resistance genes and mutations in Avian Pathogenic Escherichia coli (APEC) isolates from Shandong Province and adjacent regions in China, highlighting the high prevalence of multidrug resistance and the presence of specific resistance mechanisms such as beta-lactamases, tetracycline resistance genes, and fluoroquinolone resistance mutations.
Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
The study identified 50 acquired resistance genes and seven chromosomal-mediated gene mutations in Salmonella populations from Thai canal water, highlighting the prevalence of multidrug-resistant strains and the diversity of resistance mechanisms.
Genomic characterization of multidrug-resistant clinical Acinetobacter baumannii isolates from a hospital in Paraguay.
The study identified multiple AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Paraguay, including blaOXA-23, blaOXA-66, blaOXA-65, blaADC-73, blaADC-5, blaTEM-1, and various aminoglycoside, macrolide, sulfonamide, chloramphenicol, tetracycline, and trimethoprim resistance genes.
Clonal Dissemination of Pandrug-Resistant Klebsiella pneumoniae ST392KL27 in a Tertiary Care Hospital in Mexico.
Outbreak Caused by VIM-1- and VIM-4-Positive Proteus mirabilis in a Hospital in Zagreb.
The study reports an outbreak of carbapenem-resistant Proteus mirabilis in a psychiatric hospital in Zagreb, Croatia, characterized by the presence of VIM-1 and VIM-4 carbapenemases, along with other resistance genes such as bla CTX-M-15, bla TEM, and aminoglycoside resistance genes.
Research note: Emergence of bla(NDM-13) producing Escherichia coli from a broiler chicken and farm environment in Jiangsu Province, China.
The study identified blaNDM-13-producing E. coli strains in a chicken farm in Jiangsu Province, China, which exhibit multidrug resistance, including resistance to carbapenems, aminoglycosides, fluoroquinolones, tetracyclines, sulfonamides, and florfenicol. The study also characterizes the plasmids carrying blaNDM-13 and confirms their ability to transfer between bacteria.
Global phylogeography and genomic characterization of bla(NDM-1)-positive clinical Proteus mirabilis isolates from China.
The study identifies blaNDM-1 as a key determinant of carbapenem resistance in Proteus mirabilis isolates from China, along with other resistance genes such as blaCTX-M-14, blaCTX-M-65, and blaTEM-1. It also characterizes the genomic context of blaNDM-1, including its integration into SGI1 and plasmid-borne elements.
Antibiotic-resistance and virulence-related genes in commercially bottled natural mineral waters.
The study identified several antibiotic resistance genes (ARGs) in commercially bottled natural mineral waters, including TEM-116, ceoB, mtrA, AAC(6')-31, APH(3'')-Ib, APH(6)-Id, dfrB3, and RbpA. These genes were found to confer resistance to various antibiotics such as beta-lactams, aminoglycosides, trimethoprim, and rifampin.
Antimicrobial Resistance and Genomic Characterization of an Escherichia coli Strain Harboring p0111 and an IncX1-Type Plasmid, Isolated from the Brain of an Ostrich.
The study identifies multiple antimicrobial resistance genes in an Escherichia coli strain isolated from an ostrich, including bla CTX-M-55, rmtB, sul1, APH(6)-Id, tet(A), AAC(3)-IIc, aadA2, bla TEM-1B, and floR, which confer resistance to various antibiotics such as cephalosporins, aminoglycosides, sulfonamides, tetracyclines, and chloramphenicol.
Population structure and antimicrobial resistance of Corynebacterium diphtheriae in Victoria, Australia.
The study identified multiple AMR genes and mutations in contemporary Corynebacterium diphtheriae isolates from Victoria, Australia, including pbp2m, erm(X), aph(3')-Ia, aph(6)-Id, aph(3'')-Ib, tet(W), tet(33), tet(O), cmx, sul1, dfrA15, and mutations in gyrA and rpoB. These genes and mutations confer resistance to various antimicrobials such as penicillin, erythromycin, gentamicin, tetracycline, chloramphenicol, sulfamethoxazole, trimethoprim, ciprofloxacin, and rifampicin.
Antimicrobial resistance reservoirs in salmon and broiler processing environments, sidestreams, and waste discharges.
The study identified several high-risk AMR genes in salmon and broiler processing environments, including multidrug resistance genes TolC and mdtE, tetracycline genes tet(L) and tet(M), aminoglycoside genes APH(3′)-IIIa and APH(6)-Id, and beta-lactam genes mecA and mecR1. Additionally, the study found quinolone-resistant Escherichia coli (QREC) in waste discharges from two broiler processing plants and multidrug resistant (MDR) E. coli in one plant.
No evidence of multidrug-resistant Enterobacterales transmission between healthy companion animals and pet owners in the greater Atlanta area: a pilot study.
The study identified several AMR genes and mutations in E. coli isolates from both humans and pets, including blaCMY-2, blaCTX-M-15, blaTEM-1B, and mutations in gyrA and parC. These findings highlight the presence of multidrug-resistant Enterobacterales in healthy individuals and their companion animals.
Genomic and epidemiological characteristics of Shigella boydii in Australia, 1991-2022.
The study identified high levels of antimicrobial resistance in Shigella boydii, with over 60% of isolates classified as multidrug-resistant. Key resistance genes included blaCTX-M-15, blaCTX-M-3, blaDHA-1, mphA, sul1, sul2, dfrA1, dfrA14, dfrA5, dfrA12, dfrA17, dfrA7, aadA1, aph(3’’)-Ib, aph(6)-Id, tet(A), and tet(B). Mutations in gyrA and parC were associated with ciprofloxacin resistance and reduced susceptibility.
Azithromycin resistance in nontyphoidal Salmonella in an urban informal settlement in Nairobi, Kenya.
The study identified several AMR genes in nontyphoidal Salmonella isolates, including aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, ant(3")-Ia, sul1, sul2, dfrA1, dfrA8, tetA, mph(A), bla CTX-M-3, bla TEM-135, bla TEM-1B, and bla TEM-1C. These genes conferred resistance to various antibiotics such as aminoglycosides, sulfonamides, tetracycline, macrolides, and beta-lactams.
Genomic insights into Shigella species isolated from small ruminants and manure in the North West Province, South Africa.
The study identified multiple antibiotic resistance genes in Shigella species isolated from small ruminants and manure in South Africa, highlighting the presence of multidrug-resistant strains and the diversity of resistance mechanisms.
Genomic insights into Shigella species isolated from small ruminants and manure in the North West Province, South Africa.
The study identified multiple antibiotic resistance genes in Shigella species isolated from small ruminants and manure in South Africa, highlighting the presence of multidrug-resistant strains and the diversity of resistance mechanisms.
Global genomic survey of Salmonella Kentucky: discovery of a chromosomeborne bla(NDM-5) and the emergence of ST314, an MDR clone mediated by the IncR plasmid.
The study discovered a chromosome-borne bla(NDM-5) gene in Salmonella Kentucky and identified the IncR plasmid as a key mediator of antimicrobial resistance in the MDR clone ST314.
Genetic diversity and antimicrobial resistance profiles of Salmonella enterica in the broiler supply chain in Harare, Zimbabwe: tracking transmission from farm to table.
The study identified several AMR genes and mutations in Salmonella enterica isolates from the broiler supply chain in Zimbabwe, including fosA7.2, qnrB19, aadA1, aph(3'')-Ib, aph(6)-Id, aac(3)-Id, fosA3, sul1, sul3, tetA, cmlA1, blaCMY-2, blaTEM-1B, blaCTX-M-14, and mutations in gyrA and parC. These genes and mutations confer resistance to various antibiotics, including fosfomycin, fluoroquinolones, aminoglycosides, sulfonamides, tetracyclines, chloramphenicol, and beta-lactams.
Assessing the Genomic Landscape of Salmonella enterica Isolated From Cattle Faeces on a Nigerian Farm.
The study identified AMR genes in Salmonella enterica isolates from cattle faeces, including aph(3')-Id, aph(6)-Id, qnrB19, sul2, tet(A), and fosA7, which confer resistance to aminoglycosides, fluoroquinolones, sulfonamides, tetracyclines, and fosfomycin.
Global genomic insights into the antimicrobial resistance of Escherichia marmotae.
The study identifies bla KPC-2 and bla CTX-M-14 as significant antimicrobial resistance genes in Escherichia marmotae, highlighting its potential as a reservoir for resistance determinants.
Analysis of avian pathogenic Escherichia Coli (APEC) and its antimicrobial resistance risk characteristics and critical control points in laying hens.
The study identified several AMR genes in APEC isolates, including tet(A), floR, sul2, aph(3')-Ib, aph(6)-Id, bla TEM-1B, qnrS1, bla CTX-M-55, dfrA14, and mph(A), which contribute to resistance against tetracyclines, florfenicol, sulfonamides, aminoglycosides, beta-lactams, fluoroquinolones, and macrolides.
Genomic characterization of Klebsiella pneumoniae clinical isolates from cancer patients: resistance profiles, virulence factors, and sequence typing.
The study identified several AMR genes in K. pneumoniae isolates from cancer patients, including genes conferring resistance to trimethoprim-sulfamethoxazole, tobramycin, levofloxacin, and carbapenems. Key resistance genes included sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA27, aadA16, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aph(4)-Ia, ACC(3)-IId, ACC(3)-IIV, AAC(6')-Ib-cr, QnrS1, QnrB17, QnrB20, QnrB4, CTX-M, SHV, TEM, DHA-1, LAP-2, bla_kpc-1, bla_ndm-5, and bla_oxa-10.
Genetic and virulence factors behind the success of high-risk Pseudomonas aeruginosa clones: insights from comparative genomics and an experimental infection model.
The study identified 15 AMR genes significantly more frequent in high-risk P. aeruginosa clones, including aminoglycoside, beta-lactam, phenicol, fluoroquinolone, trimethoprim, sulfonamide, and tetracycline resistance genes. These genes are often associated with mobile genetic elements, indicating a mobility-linked resistome in high-risk clones.
Characterization of Enterobacter cloacae complex clinical isolates: comparative genomics and the role of the efflux pump AcrAB-TolC over-expression and NDM-1 production.
The study characterizes carbapenem-resistant Enterobacter cloacae complex isolates, highlighting the roles of the AcrAB-TolC efflux pump over-expression and the bla NDM-1 carbapenemase in conferring resistance. Multiple resistance genes, including bla NDM-1, acrAB-tolC, and various beta-lactamases, aminoglycoside-modifying enzymes, and sulfonamide resistance genes, were identified and validated.
Contribution of maternal gut carriage to neonatal acquisition of extended-spectrum beta-lactamase-producing Enterobacterales in Madagascar and Cambodia.
Maternal gut carriage contributes to only 16.5% of neonatal acquisition of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE), with blaCTX-M-15, blaCTX-M-55, blaCTX-M-27, blaNDM-5, blaNDM-1, sul2, aph(3')-Ib, aph(6)-Id, and tet(A) identified as key resistance determinants.
Genetic insights into antimicrobial resistance and virulence characteristics of Salmonella enterica isolated from Nile tilapia sourced from retail markets in Thailand.
The study identified multiple antimicrobial resistance (AMR) genes in Salmonella enterica isolates from Nile tilapia, including beta-lactamases (bla TEM−1B, bla CTX−M−55, bla CTX−M−14, bla LAP−2), quinolone resistance genes (qnrS1, qnrS13), tetracycline resistance genes (tet(A), tet(B), tet(M)), aminoglycoside resistance genes (aadA2, aph(3’’)-Ib, aph(6)-Id, aac(6’)-Ia), sulfonamide resistance genes (sul1, sul2, sul3), florfenicol resistance gene (floR), and efflux pump systems (mdsABC, mdtK).
Diversity of Multi-Drug Resistance Genes in Escherichia coli Isolated from Poultry in Southern Togo.
The study identified multiple AMR genes in E. coli isolates from poultry in southern Togo, including blaCTX-M-55, sul2, tet(A), floR, aph(6)-Id, aph(3")-Ib, gyrA, gyrB, parC, parE, pmrA, pmrB, folp, 23S, 16S-rrsB, 16S-rrsC, 16S-rrsH, ampC-promoter, rpoB, and mcr-1.1. These genes confer resistance to various antibiotics, highlighting the prevalence of multidrug resistance in poultry-associated E. coli.
Antimicrobial resistance, virulence defects, and evolutionary dynamics of multidrug-resistant Klebsiella pneumoniae from human and animal hosts in Central China.
The study identifies multiple AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae isolates from human and animal hosts in Central China, highlighting the role of plasmid-borne resistance genes and genetic variations affecting virulence.
Precise species identification and whole-genome sequencing analysis of Enterobacter cloacae complex causing bloodstream infections in China.
The study identified various AMR genes in Enterobacter cloacae complex (ECC) isolates, including bla ACT, bla NDM, and mcr-10, which confer resistance to beta-lactams, carbapenems, and polymyxins, respectively. It also found that E. roggenkampii was the most common species among carbapenem-resistant isolates and showed high resistance to both carbapenems and colistin.
A Monitoring Method to Evaluate the Accumulation of Antimicrobial-Resistance Genes in Gram-Negative Bacteria Distributed in Environmental Water.
The study identified multiple antimicrobial resistance genes (ARGs) in Gram-negative bacteria isolated from environmental water samples, including bla NDM-5, bla CTX-M-27, bla DHA-1, and others, indicating the presence of carbapenem-resistant and extended-spectrum beta-lactamase-producing bacteria in the Vietnamese VAC ecosystem.
Genomic and phenotypic diversity among taxonomically ambiguous clinical Corynebacterium isolates.
The study identified multiple AMR genes, including erm(X), tet(W), and aminoglycoside modifying enzymes, in various Corynebacterium species, highlighting extensive antimicrobial resistance in clinical isolates.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
The study identified mcr-1.1-harboring multidrug-resistant E. coli isolates from chicken in the UAE, highlighting the presence of various AMR genes and mutations contributing to resistance against multiple antibiotics, including colistin, beta-lactams, quinolones, and aminoglycosides.
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