apha15

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aminoglycoside phosphotransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to apha15

AMR Rules

Browse AMR rules for apha15

Validation StatusSupported

Overview

Mechanism: phosphorylation of aminoglycosides
Validation Method: expression in E. coli and MIC testing
Drug Classes: kanamycin, neomycin, aminoglycosides, amikacin, tobramycin
Organisms: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa
Geographic Location: Italy, Latvia
Papers: 3
Databases: Reslit

Papers3

In70 of plasmid pAX22, a bla(VIM-1)-containing integron carrying a new aminoglycoside phosphotransferase gene cassette.

PMID 11257042 · 2001

The study identifies a new integron, In70, carrying the bla(VIM-1) gene, which confers resistance to beta-lactams, including carbapenems, and three aminoglycoside resistance genes: aacA4, aphA15, and aadA1.

Gene Information

Gene Name: apha15
Allele: aphA15
Encodes: aminoglycoside phosphotransferase
Source Database: Reslit
Mechanism: phosphorylation of aminoglycosides
Confers Resistance To: kanamycinneomycin
Organisms Tested In: • Escherichia coli
Geographic Location: Italy
Validation Method: expression in E. coli and MIC testing
Sequence Accession: AJ278514|AJ278515

A Novel IncA/C1 Group Conjugative Plasmid, Encoding VIM-1 Metallo-Beta-Lactamase, Mediates the Acquisition of Carbapenem Resistance in ST104 Klebsiella pneumoniae Isolates from Neonates in the Intensive Care Unit of V. Monaldi Hospital in Naples.

PMID 29163422 · 2017

The study identifies a novel IncA/C1 conjugative plasmid, pIncAC_KP4898, which carries the blaVIM-1 gene and other resistance genes, mediating carbapenem resistance in ST104 Klebsiella pneumoniae isolates from neonates in the NICU of V. Monaldi Hospital in Naples.

Gene Information

Gene Name: apha15
Allele: aphA15
Encodes: aminoglycoside O-phosphotransferase
Source Database: Reslit
Confers Resistance To: aminoglycosides
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: Italy
Validation Method: genome analysis
Sequence Accession: FWYI00000000.1|KY882285

Genomic and phenotypic inconsistencies in Pseudomonas aeruginosa resistome among intensive care patients.

PMID 38975326 · 2024

The study identified several AMR genes and mutations in P. aeruginosa isolates from ICU patients, highlighting discrepancies between phenotypic and genotypic resistance profiles. Key findings include the detection of blaGES-5, aac(6')-Ib, aphA15, and mutations in gyrA and parC associated with fluoroquinolone resistance.