arcB

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Aerobic respiration control sensor protein, member of the two-component regulatory system ArcB/ArcA

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Validation StatusCandidate

Overview

Mechanism: Electron transport chain alteration
Validation Method: Whole genome sequencing
Drug Classes: polymyxin b
Organisms: Escherichia coli K-12 substr. BW25113
Papers: 1
Databases: Reslit

Papers1

Sequential antibiotic exposure restores antibiotic susceptibility.

PMID 41060280 · 2025

The study identifies several genes and mutations involved in efflux regulation and electron transport chain alterations that contribute to antibiotic resistance in E. coli. Specifically, mutations in mprA, acrR, marR, fusA, clsC, ubiD, arcB, and fre were found to be associated with resistance to various antibiotics.

Gene Information

Gene Name: arcB
Allele: arcB
Encodes: Aerobic respiration control sensor protein, member of the two-component regulatory system ArcB/ArcA
Source Database: Reslit
Mechanism: Electron transport chain alteration
Confers Resistance To: polymyxin b
Organisms Tested In: • Escherichia coli K-12 substr. BW25113
Validation Method: Whole genome sequencing

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arcB

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arcB

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