argJ

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arginine metabolic pathway gene

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UniProt

Protein entries specific to argJ

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Validation StatusCandidate

Overview

Mechanism: disruption of iron homeostasis
Validation Method: whole genome sequencing and susceptibility testing
Drug Classes: cefiderocol
Organisms: Pseudomonas aeruginosa
Papers: 1
Databases: Reslit

Papers1

Siderophores promote cooperative interspecies and intraspecies cross-protection against antibiotics in vitro.

PMID 38409256 · 2024

The study identifies cefiderocol resistance mutations in Pseudomonas aeruginosa, including cpxS variants and mexR mutations, which contribute to multidrug resistance. Additionally, increased pyoverdine production was found to confer cefiderocol resistance through iron competition.

Gene Information

Gene Name: argJ
Allele: argJ
Encodes: arginine metabolic pathway gene
Source Database: Reslit
Mechanism: disruption of iron homeostasis
Confers Resistance To: cefiderocol
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: whole genome sequencing and susceptibility testing

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argJ

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argJ

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