aroQ

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Type II 3-dehydroquinate dehydratase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to aroQ

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: Upstream mutation
Validation Method: genomic variation analysis
Drug Classes: tigecycline
Organisms: Acinetobacter baumannii
Geographic Location: Europe
Papers: 1
Databases: Reslit

Papers1

Genomic and Phenotypic Evolution of Tigecycline-Resistant Acinetobacter baumannii in Critically Ill Patients.

PMID 35044218 · 2022

The study identifies several genes and mutations associated with tigecycline resistance in Acinetobacter baumannii, including baeR, wzc, aroQ, rluC, adeS, and IS Aba1. These genetic elements contribute to the development of tigecycline resistance in clinical isolates from critically ill patients.

Gene Information

Gene Name: aroQ
Allele: aroQ
Encodes: Type II 3-dehydroquinate dehydratase
Source Database: Reslit
Mechanism: Upstream mutation
Confers Resistance To: tigecycline
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Europe
Validation Method: genomic variation analysis
Sequence Accession: JAHWVM000000000|JAHWVL000000000|JAHWVK000000000|JAHWVJ000000000|JAHWVI000000000|JAHWVH000000000|JAHWVG000000000|JAHWVF000000000|JAHWVE000000000|CP079942|JAHWWA000000000|JAHWVZ000000000|JAHWVY000000000|JAHWVX000000000|JAHWVW000000000|JAHWVV000000000|CP079945|JAHWVU000000000|JAHWVT000000000|JAHWVS000000000|JAHWVR000000000|JAHWVQ000000000|JAHWVP000000000|JAHWVO000000000|JAHWVN000000000

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aroQ

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aroQ

Gene Information