arp2

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small, hydrophobic membrane peptide

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to arp2

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Validation StatusCandidate

Overview

Mechanism: reduces membrane potential and decreases aminoglycoside uptake
Validation Method: overexpression in E. coli and measurement of MICs
Drug Classes: kanamycin, amikacin, gentamicin, streptomycin
Organisms: Escherichia coli, Salmonella enterica Typhimurium, Klebsiella pneumoniae
Papers: 1
Databases: Reslit

Papers1

De Novo Emergence of Peptides That Confer Antibiotic Resistance.

PMID 31164464 · 2019

Three novel small peptides (Arp1, Arp2, and Arp3) were identified that confer aminoglycoside resistance by reducing membrane potential and decreasing drug uptake.

Gene Information

Gene Name: arp2
Allele: Arp2
Encodes: small, hydrophobic membrane peptide
Source Database: Reslit
Mechanism: reduces membrane potential and decreases aminoglycoside uptake
Confers Resistance To: kanamycinamikacingentamicinstreptomycin
Organisms Tested In: • Escherichia coli
• Salmonella enterica Typhimurium
• Klebsiella pneumoniae
Validation Method: overexpression in E. coli and measurement of MICs
Sequence Accession: MH298521

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arp2

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arp2

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