asnB

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glutamine-dependent asparagine synthetase

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UniProt

Protein entries specific to asnB

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Validation StatusCandidate

Overview

Validation Method: transformation of the mutant with wild-type asnB of mc 2 155 or asnB of Mycobacterium tuberculosis complemented the drug sensitivity phenotype
Drug Classes: rifampicin, erythromycin, novobiocin, fusidic acid
Organisms: Mycobacterium smegmatis, Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

AsnB is involved in natural resistance of Mycobacterium smegmatis to multiple drugs.

PMID 16377694 · 2006

The study identifies AsnB as a gene involved in the natural resistance of Mycobacterium smegmatis to multiple drugs, including rifampin, erythromycin, novobiocin, and fusidic acid. Disruption of the asnB gene leads to increased sensitivity to these antibiotics.

Gene Information

Gene Name: asnB
Allele: asnB
Encodes: glutamine-dependent asparagine synthetase
Source Database: Reslit
Confers Resistance To: rifampicinerythromycinnovobiocinfusidic acid
Organisms Tested In: • Mycobacterium smegmatis
• Mycobacterium tuberculosis
Validation Method: transformation of the mutant with wild-type asnB of mc 2 155 or asnB of Mycobacterium tuberculosis complemented the drug sensitivity phenotype

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asnB

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asnB

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