Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
sensor kinase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| T200G | - | - | Klebsiella pneumoniae | cefiderocol | Reslit | Candidate |
| D181N | - | - | Klebsiella pneumoniae | cefiderocol | Reslit | Candidate |
| S437T | - | - | Acinetobacter baumannii | tigecycline | Reslit | Candidate |
| S471N | - | - | Acinetobacter baumannii | tigecycline | Reslit | Candidate |
| P474S | - | - | Acinetobacter baumannii | tigecycline | Reslit | Candidate |
| S190F | - | - | - | cefiderocol | Reslit | Candidate |
| I170S | - | - | Klebsiella pneumoniae, Escherichia coli | cefiderocol | Reslit | Candidate |
| D89V | - | two-component system sensor histidine kinase BaeS | Acinetobacter baumannii | cefiderocol | Reference Gene Catalog | Candidate |
| T175P | - | two-component system sensor histidine kinase BaeS | Enterobacter asburiae, Enterobacter cloacae, Escherichia coli | aztreonam|temocillin|ticarcillintemocillin | Reference Gene Catalog | Candidate |
| Y42H | - | two-component system sensor histidine kinase BaeS | Escherichia coli | aztreonam avibactam | Reference Gene Catalog | Candidate |
| R153P | - | two-component system sensor histidine kinase BaeS | Escherichia coli | temocillin | Reference Gene Catalog | Candidate |
| F159L | - | two-component system sensor histidine kinase BaeS | Escherichia coli | aztreonam avibactam | Reference Gene Catalog | Candidate |
| Q163E | - | two-component system sensor histidine kinase BaeS | Escherichia coli | temocillin | Reference Gene Catalog | Candidate |
| Q163H | - | two-component system sensor histidine kinase BaeS | Escherichia coli | aztreonam avibactam | Reference Gene Catalog | Candidate |
| Q163L | - | two-component system sensor histidine kinase BaeS | Escherichia coli | ceftibuten|ceftibuten avibactam | Reference Gene Catalog | Candidate |
| D111V | - | two-component system sensor histidine kinase BaeS | Klebsiella pneumoniae | aztreonam|aztreonam avibactam | Reference Gene Catalog | Candidate |
| A436T | - | - | tigecycline | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| baeS | Reslit | 3 | tigecycline, cefiderocol +2 | Acinetobacter baumannii +1 | South Africa | 2014, 2023, 2024 | NCBI:CP083125 | - |
| baes | Reslit | 1 | gentamicin | Streptococcus equi subsp. equi | China | 2023 | CP133957|CP133955|CP133956 | - |
| BaeS | Reslit | 1 | cefiderocol | Acinetobacter baumannii | - | 2023 | - | - |
| bae S | Reslit | 1 | carbapenems | Acinetobacter baumannii | - | 2024 | MK344183.1|MK344168.1 | - |
Role of the BaeSR two-component system in the regulation of Acinetobacter baumannii adeAB genes and its correlation with tigecycline susceptibility.
The BaeSR two-component system regulates the expression of the AdeAB efflux pump genes in Acinetobacter baumannii, thereby influencing tigecycline susceptibility.
Mutation in the two-component regulator BaeSR mediates cefiderocol resistance and enhances virulence in Acinetobacter baumannii.
Mutations in the two-component regulator BaeSR (D89V in BaeS and S104N in BaeR) mediate cefiderocol resistance in Acinetobacter baumannii by up-regulating efflux pump genes, particularly MFS transporters and MacAB-TolC. Additionally, the BaeS mutation increases virulence by up-regulating the paa operon.
Complete genome sequencing and comparative genomic analysis of three donkey Streptococcus equi subsp. equi isolates.
The study identified multiple antibiotic resistance genes in three donkey-derived Streptococcus equi subsp. equi isolates, including genes conferring resistance to beta-lactams, tetracyclines, macrolides, fluoroquinolones, and others. Notably, the HT1112 isolate showed resistance to six antimicrobials, while HTP133 and HTP232 showed resistance to fewer drugs. Additionally, the study highlighted the role of biofilm formation in antimicrobial resistance.
Cefiderocol and Sulbactam-Durlobactam against Carbapenem-Resistant Acinetobacter baumannii.
The study characterizes several AMR genes and mutations involved in resistance to cefiderocol in Acinetobacter baumannii, including blaPER-1, blaNDM-1, blaADC-25, blaADC-33, pirA, piuA, BaeS, BaeR, and specific mutations in PirA and PBP3.
Genome mining of Escherichia coli WG5D from drinking water source: unraveling antibiotic resistance genes, virulence factors, and pathogenicity.
The study identifies multiple antibiotic resistance genes in E. coli WG5D, including multidrug efflux pumps and genes conferring resistance to various antibiotics such as fluoroquinolones, cephalosporins, and glycopeptides.
Based on molecular docking and real-time PCR technology, the two-component system Bae SR was investigated on the mechanism of drug resistance in CRAB.
The two-component system Bae SR was found to play a critical role in carbapenem resistance in CRAB, with increased expression of bae S and bae R genes correlating with higher resistance levels.
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