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basRS

two-component regulatory system

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to basRS

Browse AMR rules for basRS

Overview

Drug Classes: colistin
Organisms: Escherichia coli
Papers: 1
Mutations: 3

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
L10R	-	-	Escherichia coli	colistin	Reslit	Candidate
G53S	-	-	Escherichia coli	colistin	Reslit	Candidate
A159P	-	-	Escherichia coli	colistin	Reslit	Candidate

Papers1

1

Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates.

PMID 32161146 · 2020

Mutations in the basRS genes contribute to colistin resistance in E. coli.

Mutation Information

basRS: p.L10R basRS: p.G53S basRS: p.A159P

Protein Change: L10R, G53S, A159P
Organisms: Escherichia coli
Confers Resistance To: colistin
Validation Method: chromosomal transgene insertion mutants
Source Database: Reslit