bioB

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biotin synthase

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Validation StatusCandidate

Overview

Validation Method: proteomic and metabolomic analysis showing increased biotin levels
Drug Classes: para aminosalicylic acid
Organisms: Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

Multi-omics comparisons of p-aminosalicylic acid (PAS) resistance in folC mutated and un-mutated Mycobacterium tuberculosis strains.

PMID 30866779 · 2019

The study identifies folC mutations and dfrA overexpression as key mechanisms of p-aminosalicylic acid (PAS) resistance in Mycobacterium tuberculosis. folC mutations reduce PAS bioactivation, while dfrA overexpression compensates for PAS-induced folate depletion.

Gene Information

Gene Name: bioB
Allele: bioB
Encodes: biotin synthase
Source Database: Reslit
Confers Resistance To: para aminosalicylic acid
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: proteomic and metabolomic analysis showing increased biotin levels
Sequence Accession: NCBI:CP031115|NCBI:CP031116

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bioB

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bioB

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