bla(KLUC)

β-lactamase

Overview

Drug Classes: cefotaxime|ceftriaxone, cefotaxime|ceftazidime|ceftriaxone
Organisms: Klebsiella pneumoniae, Escherichia coli
Papers: 1
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S18G	-	-	Klebsiella pneumoniae, Escherichia coli	cefotaxime\|ceftriaxone	Reslit	Candidate
D240G	-	-	Klebsiella pneumoniae, Escherichia coli	cefotaxime\|ceftazidime\|ceftriaxone	Reslit	Candidate

Papers1

Characterization of a Novel bla(KLUC) Variant With Reduced β-Lactam Resistance From an IncA/C Group Plasmid in a Clinical Klebsiella pneumoniae Isolate.

PMID 30158920 · 2018

The wild-type bla(KLUC) gene shows reduced resistance activity compared to previously identified variants.

Mutation Information

bla(KLUC): p.S18G bla(KLUC): p.D240G

Protein Change: S18G, D240G
Organisms: Klebsiella pneumoniae, Escherichia coli
Confers Resistance To: cefotaxime|ceftriaxonecefotaxime|ceftazidime|ceftriaxone
Validation Method: site-directed mutagenesis
Source Database: Reslit

bla(KLUC)

Mutations

Mutation Information

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bla(KLUC)

Mutations

Mutation Information