Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
class A beta-lactamase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| P167S | - | - | Burkholderia pseudomallei | ceftazidime | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| BlaA | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 26 | ceftazidime, BETA-LACTAM +13 | Burkholderia pseudomallei +20 | Thailand|Canada, India, Oklahoma, Brussels, Belgium, France|Belgium|Germany|USA, Spain, India|Malaysia|South China, France|Baulon|Crozon|Plounéour-Ménez|Trégastel, Switzerland, Sardinia | 1991, 2003, 2006, 2007, 2011, 2013, 2014, 2015, 2016, 2017, 2018, 2020, 2021, 2022, 2023, 2024 | AY032868|AY032869|AY032870|AY032871|AY032872|AY032873|AY032874 | AAX55643.1 |
| blaA | ResFinder Database | 1 | UNKNOWN BETA-LACTAM | Yersinia intermedia, Yersinia enterocolitica | - | 2007 | DQ424965, AY954728 | - |
| blaA-1 | Reslit | 1 | penicillin | Escherichia coli | - | 2022 | - | - |
Burkholderia pseudomallei class a beta-lactamase mutations that confer selective resistance against ceftazidime or clavulanic acid inhibition.
The study identifies specific mutations in the class A beta-lactamase gene (blaA) of Burkholderia pseudomallei that confer resistance to ceftazidime and clavulanic acid. These mutations occur in conserved regions of the enzyme, affecting its ability to be inhibited by these antibiotics.
Molecular characterization of beta-lactamase genes blaA and blaB of Yersinia enterocolitica biovar 1A.
Molecular characterization of beta-lactamase genes blaA and blaB of Yersinia enterocolitica biovar 1A.
Molecular characterization of beta-lactamase genes blaA and blaB of Yersinia enterocolitica biovar 1A.
The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081.
Characteristics of beta-lactamases and their genes (blaA and blaB) in Yersinia intermedia and Y. frederiksenii.
The study identified and characterized the beta-lactamases Bla-A and Bla-B in Yersinia intermedia and Y. frederiksenii, showing their presence in all clinical and non-clinical strains and demonstrating their role in resistance to penicillins and cephalosporins.
Characteristics of beta-lactamases and their genes (blaA and blaB) in Yersinia intermedia and Y. frederiksenii., Molecular characterization of beta-lactamase genes blaA and blaB of Yersinia enterocolitica biovar 1A.
Nucleotide sequence of a new class A beta-lactamase gene from the chromosome of Yersinia enterocolitica: implications for the evolution of class A beta-lactamases.
Partial Genome Assembly for a Candidate Division OP11 Single Cell from an Anoxic Spring (Zodletone Spring, Oklahoma).
The study identifies a beta-lactamase (blaA) and an aminoglycoside adenyltransferase (aadA) in the OP11 single cell genome, indicating resistance to beta-lactam and aminoglycoside antibiotics.
Expression of blaA underlies unexpected ampicillin-induced cell lysis of Shewanella oneidensis.
The study identifies blaA as the primary beta-lactamase responsible for ampicillin resistance in Shewanella oneidensis. Insufficient expression of blaA leads to ampicillin-induced cell lysis.
Identification of a metagenomic gene cluster containing a new class A beta-lactamase and toxin-antitoxin systems.
A new class A beta-lactamase gene (blaA) was identified in a metagenomic fosmid library from a polluted river, conferring resistance to multiple beta-lactam antibiotics.
Molecular analysis of beta-lactamase genes to understand their differential expression in strains of Yersinia enterocolitica biotype 1A.
Distinct roles of major peptidoglycan recycling enzymes in beta-lactamase production in Shewanella oneidensis.
The study identifies blaA as a key gene responsible for β-lactam resistance in Shewanella oneidensis, showing that its expression is regulated by peptidoglycan recycling enzymes. Deletion of nagZ or ampG leads to increased β-lactam resistance, which is dependent on the presence of blaA.
Covalent docking of large libraries for the discovery of chemical probes.
The study describes a computational method for discovering covalent chemical probes that target specific protein residues, including beta-lactamase inhibitors and kinase inhibitors. Experimental validation confirmed the effectiveness of these inhibitors against AmpC beta-lactamase and RSK2/MSK1 kinases.
PBP1a/LpoA but not PBP1b/LpoB are involved in regulation of the major beta-lactamase gene blaA in Shewanella oneidensis.
The study identifies that inactivation of PBP1a/LpoA enhances the expression of the beta-lactamase gene blaA in Shewanella oneidensis, leading to increased resistance to β-lactam antibiotics such as ampicillin, cefotaxime, and imipenem.
Sensor histidine kinase is a β-lactam receptor and induces resistance to β-lactam antibiotics.
The study identifies VbrK as a β-lactam receptor that triggers beta-lactamase expression in Vibrio parahaemolyticus, leading to β-lactam resistance.
Asymmetric cellular memory in bacteria exposed to antibiotics.
The study identified that Caulobacter crescentus possesses a naturally occurring resistance mechanism to ampicillin involving beta-lactamase genes, which is activated upon exposure to sub-MIC levels of ampicillin.
Deletion of Lytic Transglycosylases Increases Beta-Lactam Resistance in Shewanella oneidensis.
Deletion of specific lytic transglycosylases (SltY, MltB, and MltB2) in Shewanella oneidensis leads to increased β-lactam resistance, mediated by upregulation of the class D beta-lactamase gene blaA.
Isolation of a Yersinia enterocolitica biotype 1B strain in France, and evaluation of its genetic relatedness to other European and North American biotype 1B strains.
The study identified the blaA gene responsible for beta-lactam resistance and the vatF gene responsible for streptogramin B resistance in a Yersinia enterocolitica biotype 1B strain.
Antimicrobial Susceptibility and Characterization of Resistance Mechanisms of Corynebacterium urealyticum Clinical Isolates.
The study identified blaA as a beta-lactamase gene responsible for ampicillin resistance, ermX as a gene responsible for erythromycin resistance, and mutations in gyrA and rpoB associated with levofloxacin and rifampicin resistance in Corynebacterium urealyticum isolates.
Foodborne Pathogenic Vibrios: Antimicrobial Resistance.
The paper discusses the presence of various antibiotic resistance genes in Vibrio species, including strB, sul2, tetA, blaTEM, qnrA, ermB, floR, aac(3)-IIa, blaNDM-1, blaCMY, blaP1, catB3, and others, which confer resistance to antibiotics such as streptomycin, sulfamethoxazole, tetracycline, ampicillin, fluoroquinolones, erythromycin, florfenicol, gentamicin, carbapenems, chloramphenicol, and trimethoprim.
New Beta-lactamases in Candidate Phyla Radiation: Owning Pleiotropic Enzymes Is a Smart Paradigm for Microorganisms with a Reduced Genome.
The study identified five putative beta-lactamase-encoding genes from the CPR resistome, which exhibited hydrolytic activity against certain beta-lactam antibiotics and RNA. These enzymes were expressed in E. coli and characterized using biochemical assays.
Rhizocarpon geographicum Lichen Discloses a Highly Diversified Microbiota Carrying Antibiotic Resistance and Persistent Organic Pollutant Tolerance.
The study identified multiple AMR genes in lichen-associated bacteria, including beta-lactamases, efflux pump components, and enzymes conferring resistance to various antibiotics. These findings highlight the diverse AMR profiles of bacteria inhabiting extreme environments.
Recent Advances in Methods to Detect Drug-Resistant Mtb
The paper discusses intrinsic and acquired drug resistance mechanisms in Mycobacterium tuberculosis, highlighting beta-lactamases (blaA, blaC, blaE), erm gene-mediated macrolide/lincosamide/streptogramin B resistance, mfpA-mediated fluoroquinolone/viomycin/capreomycin resistance, and the role of the Eis protein in aminoglycoside resistance. It also identifies mutations in rpoB and gyrA associated with rifampicin and fluoroquinolone resistance.
Differential effects of wastewater treatment plant effluents on the antibiotic resistomes of diverse river habitats.
The study identifies aadA, sul1, and blaA as genes that show increased abundance in river water downstream of wastewater treatment plants, suggesting their potential as indicators of wastewater-related pollution.
Predicting Salmonella MIC and Deciphering Genomic Determinants of Antibiotic Resistance and Susceptibility.
The study presents a novel 'Genome Feature Extractor Pipeline' that uses machine learning and deep learning to predict Salmonella MIC values based on 20-mer counts from WGS data. The pipeline identifies key genomic features associated with antibiotic resistance, including known resistance genes such as beta-lactamases, aminoglycoside modifying enzymes, quinolone resistance genes, tetracycline efflux pumps, and sulfonamide resistance genes.
Potential involvement of beta-lactamase homologous proteins in resistance to beta-lactam antibiotics in gram-negative bacteria of the ESKAPEE group.
The study identifies and characterizes beta-lactamase homologous proteins in gram-negative bacteria of the ESKAPEE group, highlighting their potential role in resistance to beta-lactam antibiotics.
Salmonella and Yersinia enterocolitica through the pig meat chain in Sardinia: occurrence, antimicrobial resistance and genetic insight.
The study identified AMR genes blaTEM-1B, sul2, aph(3')-Ib, and tet(B) in Salmonella Typhimurium ST34 isolates, and blaA in Yersinia enterocolitica biotype 2 isolates, indicating resistance to various antibiotics.
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