Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
subclass B1 metallo-beta-lactamase AFM-4
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaAFM-4 | Card DatabaseReference Gene CatalogReslit | 3 | CARBAPENEM, meropenem +6 | Pseudomonas aeruginosa +1 | China | 2022 | OM049002.1 | UIC51886.1 |
| blaAFM-5 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Pseudomonas guariconensis | - | - | AP035765.1 | BFO05841.1 |
| blaAFM-1 | Card DatabaseReference Gene CatalogReslit | 8 | ampicillin, cefoxitin +4 | Alcaligenes faecalis +4 | China | 2021, 2023, 2025 | NG_063835.1 | WP_069953510.1 |
| blaAFM-2 | Card DatabaseReference Gene CatalogReslit | 6 | CARBAPENEM, meropenem +7 | Pseudomonas aeruginosa +1 | China, China|Australia | 2022, 2025 | NG_073458.1 | WP_204376224.1 |
| blaAFM-3 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Pseudomonas aeruginosa | - | 2022 | MW811438.1 | QTH36338.1 |
| bla(AFM-1) | Reslit | 1 | carbapenems | Alcaligenes faecalis +3 | Guangzhou, China | 2023 | MK143105.1 | - |
Molecular and Functional Characterization of a Novel Plasmid-Borne bla (NDM)-Like Gene, bla (AFM-1), in a Clinical Strain of Aeromonas hydrophila.
A novel plasmid-borne bla NDM-like gene, bla AFM-1, was identified in a multidrug-resistant clinical strain of Aeromonas hydrophila SS332. The gene was functionally characterized and shown to confer resistance to ampicillin, cefazolin, cefoxitin, and ceftazidime.
Characterization of the novel plasmid-encoded MBL gene blaAFM-1, integrated into a blaIMP-45-bearing transposon Tn6485e in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate.
Characterization of the novel plasmid-encoded MBL gene blaAFM-1, integrated into a blaIMP-45-bearing transposon Tn6485e in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate.
Alcaligenes faecalis metallo-β-lactamase in extensively drug-resistant Pseudomonas aeruginosa isolates.
Alcaligenes faecalis metallo-β-lactamase in extensively drug-resistant Pseudomonas aeruginosa isolates.
Alcaligenes faecalis metallo-β-lactamase in extensively drug-resistant Pseudomonas aeruginosa isolates.
Alcaligenes faecalis metallo-β-lactamase in extensively drug-resistant Pseudomonas aeruginosa isolates.
Rapid detection of a novel B1-beta-lactamase gene, blaAFM-1 using a loop-mediated isothermal amplification (LAMP) assay.
The study reports the identification and characterization of a novel B1-beta-lactamase gene, blaAFM-1, which confers resistance to carbapenems. A LAMP assay was developed for rapid and accurate detection of this gene.
Plasmid-Borne AFM Alleles in Pseudomonas aeruginosa Clinical Isolates from China.
The study identified two plasmid-borne AFM alleles, AFM-2 and AFM-4, in Pseudomonas aeruginosa clinical isolates from China. Both alleles conferred resistance to multiple beta-lactam antibiotics, with AFM-4 being a novel variant detected in a strain isolated from a water sink.
Plasmid-Borne AFM Alleles in Pseudomonas aeruginosa Clinical Isolates from China.
The study identified two plasmid-borne AFM alleles, AFM-2 and AFM-4, in Pseudomonas aeruginosa clinical isolates from China. Both alleles conferred resistance to multiple beta-lactam antibiotics, with AFM-4 being a novel variant detected in a strain isolated from a water sink.
An XDR Pseudomonas aeruginosa ST463 Strain with an IncP-2 Plasmid Containing a Novel Transposon Tn6485f Encoding bla(IMP-45) and bla(AFM-1) and a Second Plasmid with Two Copies of bla(KPC-2).
The study identifies a novel transposon Tn6485f containing blaIMP-45 and blaAFM-1, along with a second plasmid with two copies of blaKPC-2, contributing to the XDR phenotype of the P. aeruginosa ST463 strain PA30.
Characterization of bla(AFM-1)-positive carbapenem-resistant strains isolated in Guangzhou, China.
The study characterizes the bla(AFM-1) gene, which encodes a metallo-beta-lactamase capable of hydrolyzing carbapenems. This gene was identified in multiple bacterial species and can be horizontally transferred via plasmid conjugation.
Pseudomonas aeruginosa High-Risk Sequence Type 463 Co-Producing KPC-2 and AFM-1 Carbapenemases, China, 2020-2022.
The study reports the clonal spread of Pseudomonas aeruginosa sequence type 463 co-producing KPC-2 and AFM-1 carbapenemases in China, highlighting their extensive drug resistance, disinfectant and desiccation resilience, and strong biofilm formation capabilities.
Diverse modes of ceftazidime/avibactam resistance acquisition in carbapenem-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa from a Chinese intensive care unit.
The study identifies bla KPC-87, bla AFM-2, and bla PER-1 as key genes responsible for ceftazidime/avibactam resistance in carbapenem-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae. Additionally, the GT241A substitution in KPC-87 and the presence of Δ bla TEM-1 contribute to resistance mechanisms.
Evolution of XDR Pseudomonas aeruginosa ST463 strains with two plasmids harboring multiple antimicrobial resistance genes.
The study identifies multiple antimicrobial resistance genes, including blaIMP-45, blaAFM-1, and blaKPC-2, in XDR Pseudomonas aeruginosa ST463 strains, highlighting their role in carbapenem resistance.
New resistance threat in difficult-to-treat resistance Pseudomonas aeruginosa co-producing AFM and KPC carbapenemases: plasmid dynamic transfer and global phylogeography perspective.
The study identifies bla AFM-2 and bla KPC-2 as critical resistance genes in Pseudomonas aeruginosa isolates, highlighting their role in carbapenem resistance and the potential for plasmid-mediated spread in hospital settings.
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