Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
carbapenem-hydrolyzing class A beta-lactamase AXC-1
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaAXC-1 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Achromobacter xylosoxidans | - | - | MF767301.1 | ATG32091.1 |
| blaAXC-10 | Reference Gene Catalog | 1 | CARBAPENEM | Achromobacter ruhlandii | - | - | PX758176.1 | YCN16003.1 |
| blaAXC-11 | Reference Gene Catalog | 1 | CARBAPENEM | Achromobacter ruhlandii | - | - | PX758177.1 | YCN16004.1 |
| blaAXC-12 | Reference Gene Catalog | 1 | CARBAPENEM | Achromobacter ruhlandii | - | - | PX758178.1 | YCN16005.1 |
| blaAXC-13 | Reference Gene Catalog | 1 | CARBAPENEM | Achromobacter xylosoxidans | - | - | PX758179.1 | YCN16006.1 |
| blaAXC-2 | Card DatabaseReference Gene CatalogReslit | 4 | CARBAPENEM, cefepime +1 | Achromobacter ruhlandii +1 | Taiwan | 2025 | MH742744.1 | AXM44138.1 |
| blaAXC-3 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Achromobacter ruhlandii | - | - | MH742745.1 | AXM44139.1 |
| blaAXC-4 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Achromobacter xylosoxidans | - | - | MN339509.1 | QEJ74006.1 |
| blaAXC-5 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Achromobacter xylosoxidans | - | - | MN370453.1 | QEJ80833.1 |
| blaAXC-6 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Achromobacter ruhlandii | - | - | MZ025964.1 | QUR41148.1 |
| blaAXC-7 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Achromobacter xylosoxidans | - | - | OL516042.1 | UGN25768.1 |
| blaAXC-8 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Achromobacter ruhlandii | - | - | LC834166.1 | BFR50331.1 |
| blaAXC-9 | Reference Gene Catalog | 1 | CARBAPENEM | Achromobacter ruhlandii | - | - | PX758175.1 | YCN16002.1 |
| blaAxc | Reslit | 1 | carbapenems | Achromobacter xylosoxidans +1 | - | 2018 | MF767301 | - |
| bla_AXC-2 | Reslit | 1 | ampicillin | Escherichia coli +1 | Argentina | 2024 | MH742744 | - |
| blaAXC | Reslit | 2 | carbapenems, meropenem +1 | Achromobacter xylosoxidans +1 | United States | 2025 | CP068211.1|CP068212.1|CP038034.1|CP053986.1 | - |
Proteomic identification of Axc, a novel beta-lactamase with carbapenemase activity in a meropenem-resistant clinical isolate of Achromobacter xylosoxidans.
A novel beta-lactamase, Axc, was identified as a carbapenemase in a meropenem-resistant isolate of Achromobacter xylosoxidans. Axc conferred resistance to carbapenems when expressed in E. coli.
Genetic and Biochemical Characterization of AXC-2 from Achromobacter ruhlandii.
The study characterized AXC-2, a beta-lactamase from Achromobacter ruhlandii, which shows increased resistance to ampicillin and cephalexin. AXC-2 had limited hydrolytic activity against carbapenems.
Comparative phenotypic and genotypic antimicrobial susceptibility surveillance in Achromobacter spp. through whole genome sequencing.
The study identifies multiple AMR genes in Achromobacter spp., including RND-type efflux pumps and various beta-lactamases, which contribute to resistance against multiple antibiotics.
Defining antimicrobial susceptibility testing methods and breakpoints among Achromobacter species.
The study identifies several beta-lactamase genes, including bla OXA-114, bla AXC, bla VIM-4, and bla AMZ-1, which confer resistance to carbapenems in Achromobacter species. These findings are crucial for establishing antimicrobial susceptibility testing breakpoints.
Genomic heterogeneity and lineage-specific beta-lactamases in recurrent Achromobacter bloodstream infection patients.
The study identifies lineage-specific beta-lactamases, including blaOXA-114f, blaOXA-114w, blaOXA-114j, blaOXA-114i, blaOXA-1238, blaOXA-364, and AXC-2, in Achromobacter isolates. It also finds missense mutations in genes such as siaT, rapA, atzEa1, AL523_09115, and clpA that correlate with changes in antimicrobial resistance profiles.
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