Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
CDD beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaCDD-1 | Card DatabaseReference Gene CatalogReslit | 7 | penicillin, cephalosporins +3 | Clostridioides difficile CD43 +4 | Northern Germany, South Africa | 2018, 2021, 2023, 2025 | NG_065860.1 | WP_009901927.1 |
| blaCDD-2 | Card DatabaseReference Gene CatalogReslit | 6 | penicillin, cephalosporins +3 | Clostridioides difficile CD13 +3 | Northern Germany, South Africa | 2018, 2023, 2025 | NG_065861.1 | WP_021361759.1 |
| blaCDD | Reslit | 2 | ampicillin, cephalosporins | Clostridioides difficile +1 | - | 2019, 2025 | NC_009089.1|FN665653.1 | - |
| bla_CDD-1 | Reslit | 1 | penicillin, ampicillin | Clostridioides difficile | Germany | 2023 | NC_009089|NC_008226 | - |
Intrinsic Class D beta-lactamases of Clostridium difficile.
The study identifies intrinsic class D beta-lactamases, CDD-1 and CDD-2, in Clostridium difficile, which confer resistance to various β-lactam antibiotics. These enzymes show broad-spectrum activity and are poorly expressed under their own promoters but can confer high-level resistance when expressed under efficient promoters.
Intrinsic Class D beta-lactamases of Clostridium difficile.
The study identifies intrinsic class D beta-lactamases, CDD-1 and CDD-2, in Clostridium difficile, which confer resistance to various β-lactam antibiotics. These enzymes show broad-spectrum activity and are poorly expressed under their own promoters but can confer high-level resistance when expressed under efficient promoters.
Intrinsic Class D β-Lactamases of Clostridium difficile.
Intrinsic Class D β-Lactamases of Clostridium difficile.
Intrinsic Class D β-Lactamases of Clostridium difficile.
Intrinsic Class D β-Lactamases of Clostridium difficile.
Regulation and Anaerobic Function of the Clostridioides difficile beta-lactamase
The study identifies blaCDD as a beta-lactamase gene in Clostridioides difficile that is induced by β-lactam antibiotics and contributes to ampicillin resistance. The gene is part of an operon with blaX, which enhances BlaCDD activity.
Inhibition of the Clostridioides difficile Class D beta-lactamase CDD-1 by Avibactam.
Avibactam is a potent irreversible inhibitor of the CDD-1 beta-lactamase from Clostridioides difficile, significantly reducing the susceptibility of bacteria to cephalosporins.
Clostridioides difficile in South American Camelids in Germany: First Insights into Molecular and Genetic Characteristics and Antimicrobial Resistance.
The study identified several AMR genes and mutations in C. difficile isolates from South American camelids in Germany, including bla_CDD-1, vanZ1, aadE, tet(M), tet(40), vanG, vanR, vanS, vanT, and mutations in gyrA and gyrB associated with fluoroquinolone resistance.
Clostridioides difficile from Fecally Contaminated Environmental Sources: Resistance and Genetic Relatedness from a Molecular Epidemiological Perspective.
The study identified multiple AMR genes in C. difficile isolates from environmental sources, including gyrA, gyrB, blaCDD-1, blaCDD-2, tet(M), tet(40), aph(3')-IIIa, ant(6)-la, sat-4, and ermB, which confer resistance to fluoroquinolones, beta-lactams, tetracyclines, aminoglycosides, and MLS B antibiotics.
Clostridioides difficile from Fecally Contaminated Environmental Sources: Resistance and Genetic Relatedness from a Molecular Epidemiological Perspective.
The study identified multiple AMR genes in C. difficile isolates from environmental sources, including gyrA, gyrB, blaCDD-1, blaCDD-2, tet(M), tet(40), aph(3')-IIIa, ant(6)-la, sat-4, and ermB, which confer resistance to fluoroquinolones, beta-lactams, tetracyclines, aminoglycosides, and MLS B antibiotics.
Differential gene expression analysis shows that cephalosporin resistance is intrinsic to Clostridioides difficile strain 630.
The study identifies blaCDD, CD630_04590, and CD630_04600 as genes upregulated in response to cephalosporin exposure in C. difficile strain 630, but their roles in resistance remain unclear as their deletion did not significantly affect resistance.
Phenotypic and genotypic antimicrobial resistance profiles of clinical Clostridioides difficile isolates collected from private and public health settings in South Africa.
The study identified a PnimB promoter mutation associated with reduced metronidazole susceptibility in ST1 strains, a Thr82Ile mutation in gyrA linked to fluoroquinolone resistance, and various efflux pump and resistance genes such as qacG, aac(6')-Ie-aph(2'')-Ia, ermB, tetM, and CDD-1/CDD-2. High multidrug resistance (MDR) was observed in ST1 and ST37 strains.
Phenotypic and genotypic antimicrobial resistance profiles of clinical Clostridioides difficile isolates collected from private and public health settings in South Africa.
The study identified a PnimB promoter mutation associated with reduced metronidazole susceptibility in ST1 strains, a Thr82Ile mutation in gyrA linked to fluoroquinolone resistance, and various efflux pump and resistance genes such as qacG, aac(6')-Ie-aph(2'')-Ia, ermB, tetM, and CDD-1/CDD-2. High multidrug resistance (MDR) was observed in ST1 and ST37 strains.
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