Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
class C beta-lactamase CMY-104
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaCMY-104 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter sp. OTESBL0707 | - | - | KF150216.1 | AGR82311.1 |
| blaCMY-105 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KJ207205.1 | AHL39330.1 |
| blaCMY-106 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KM983294.1 | AJH76980.1 |
| blaCMY-109 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | AJ746169.1 | CAG34070.1 |
| blaCMY-112 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KM087837.1 | AIT76090.1 |
| blaCMY-113 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KM087836.1 | AIT76089.1 |
| blaCMY-114 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KM087846.1 | AIT76099.1 |
| blaCMY-115 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KM087839.1 | AIT76092.1 |
| blaCMY-116 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +16 | Citrobacter freundii | East Africa|Uganda | 2024 | KM087840.1 | AIT76093.1 |
| blaCMY-117 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Citrobacter freundii +1 | Czech Republic | 2023 | KM087844.1 | AIT76097.1 |
| blaCMY-118 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KM087838.1 | AIT76091.1 |
| blaCMY-119 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KM087845.1 | AIT76098.1 |
| blaCMY-121 | Card DatabaseReference Gene CatalogResFinder Database | 4 | CEPHALOSPORIN, TICARCILLIN +10 | Vibrio parahaemolyticus +1 | - | - | JARKDJ010000011.1 | MDF5212623.1 |
| blaCMY-122 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, CEPHALOSPORIN +12 | Citrobacter freundii | China | 2021 | KM985460.1 | AKO62859.1 |
| blaCMY-124 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KM985462.1 | AKO62861.1 |
| blaCMY-125 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KM985463.1 | AKO62862.1 |
| blaCMY-127 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KM985465.1 | AKO62864.1 |
| blaCMY-128 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KM985466.1 | AKO62865.1 |
| blaCMY-129 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KM985467.1 | AKO62866.1 |
| blaCMY-131 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | KP281294.1 | AKG51729.1 |
| blaCMY-132 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | KP862820.1 | AKZ20822.1 |
| blaCMY-133 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | KP862819.1 | AKZ20821.1 |
| blaCMY-137 | Card DatabaseReference Gene CatalogReslit | 3 | CEPHALOSPORIN, ampicillin +3 | Citrobacter freundii +1 | China | 2016 | LIDR01000193.1 | WP_053390271.1 |
| blaCMY-138 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Proteus mirabilis | - | - | KT997883.1 | ALM96710.1 |
| blaCMY-139 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | KU641016.1 | AMK49571.1 |
| blaCMY-140 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | KX354367.1 | ANJ78051.1 |
| blaCMY-141 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | KX537750.1 | ANS56705.1 |
| blaCMY-142 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | KX881969.1 | AOS70335.1 |
| blaCMY-143 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | KY009534.1 | AOX21805.1 |
| blaCMY-144 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KY066478.1 | APC23883.1 |
| blaCMY-145 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, CEPHALOSPORIN +13 | Escherichia coli | Australia | 2024 | KX470426.2 | APD79118.2 |
| blaCMY-147 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | KY563765.1 | AQM40187.1 |
| blaCMY-148 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | TICARCILLIN, CEPHALOSPORIN +14 | Escherichia coli | Thailand, Kathmandu, Nepal | 2024, 2025 | KY624573.1 | AQS23583.1 |
| blaCMY-149 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Proteus mirabilis | - | - | KY624574.1 | AQS23584.1 |
| blaCMY-151 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KY780116.1 | ARE65229.1 |
| blaCMY-152 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Citrobacter freundii | China | 2018 | KY978224.1 | ARM19732.1 |
| blaCMY-153 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | MF042206.1 | ARQ85812.1 |
| blaCMY-154 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | MF196231.1 | ARX70574.1 |
| blaCMY-155 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Klebsiella sp. KF07 | - | - | KR261698.1 | ALF62843.1 |
| blaCMY-157 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Citrobacter sp. | - | - | MF795088.1 | ASW32315.1 |
| blaCMY-160 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Escherichia coli | - | - | MH243359.1 | AWI33313.1 |
| blaCMY-161 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Escherichia coli | - | - | MH067963.1 | AVP74338.1 |
| blaCMY-162 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Escherichia coli | - | - | MH378228.1 | AWR93229.1 |
| blaCMY-163 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Escherichia coli | - | - | MH450208.1 | AWU66456.1 |
| blaCMY-164 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Escherichia coli | - | - | MK965968.1 | QCT85446.1 |
| blaCMY-165 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Escherichia coli | - | - | MN104598.1 | QDM39443.1 |
| blaCMY-167 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Proteus mirabilis | - | - | MN219694.1 | QDY98371.1 |
| blaCMY-168 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Providencia stuartii | - | - | MN550986.1 | QFR38193.1 |
| blaCMY-169 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Providencia rettgeri | - | - | MN550987.1 | QFR38194.1 |
| blaCMY-170 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Klebsiella pneumoniae | - | - | MN550988.1 | QFR38195.1 |
| blaCMY-171 | Card DatabaseReference Gene CatalogReslit | 4 | CEPHALOSPORIN, cefotaxime +1 | Escherichia coli | Northwest Spain | 2020 | MN164523.1 | QHD25689.1 |
| blaCMY-173 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Escherichia coli | - | - | MT994367.1 | QNS29746.1 |
| blaCMY-174 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Klebsiella pneumoniae | - | - | CP066542.1 | QQL36767.1 |
| blaCMY-175 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Citrobacter portucalensis | - | - | MZ092822.1 | QVO43829.1 |
| blaCMY-176 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Citrobacter portucalensis | - | - | MZ092823.1 | QVO43830.1 |
| blaCMY-177 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Klebsiella oxytoca | - | - | OK217282.1 | UBL87560.1 |
| blaCMY-179 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Citrobacter meridianamericanus | - | - | OL606718.1 | UGN21642.1 |
| blaCMY-180 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Citrobacter freundii | - | - | OL445412.1 | UQM99654.1 |
| blaCMY-181 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Citrobacter freundii | - | - | OP081530.1 | UUG60967.1 |
| blaCMY-182 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Citrobacter braakii | - | - | LC733684.1 | BDT38919.1 |
| blaCMY-183 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Citrobacter portucalensis | - | - | LC733685.1 | BDT38920.1 |
| blaCMY-184 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Escherichia coli | - | - | OP950674.1 | WAK12379.1 |
| blaCMY-186 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Klebsiella pneumoniae | - | - | JASAUU010000053.1 | MDI2051974.1 |
| blaCMY-187 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Escherichia coli | - | - | OR209683.1 | WJR95508.1 |
| blaCMY-188 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Citrobacter freundii | - | - | OR562100.1 | WNH41907.1 |
| blaCMY-190 | Card DatabaseReference Gene CatalogReslit | 3 | CEPHALOSPORIN, cephalosporins | Citrobacter youngae +1 | China | 2025 | OR896917.1 | WPR17911.1 |
| blaCMY-191 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Escherichia coli | - | - | PP575761.1 | WZE64858.1 |
| blaCMY-194 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Providencia stuartii | - | - | PQ374838.1 | XHJ89679.1 |
| blaCMY-195 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Escherichia coli | - | - | PQ394536.1 | XHO32879.1 |
| blaCMY-196 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Escherichia coli | - | - | PQ394537.1 | XHO32880.1 |
| blaCMY-197 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Escherichia coli | - | - | PQ394538.1 | XHO32881.1 |
| blaCMY-198 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Escherichia coli | - | - | PQ394539.1 | XHO32882.1 |
| blaCMY-199 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Escherichia coli | - | - | PQ394540.1 | XHO32883.1 |
| blaCMY-200 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter sp. | - | - | PV075191.1 | XOU30655.1 |
| blaCMY-201 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | - | PV075192.1 | XOU30656.1 |
| blaCMY-202 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | - | PV075193.1 | XOU30657.1 |
| blaCMY-203 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | - | PV075194.1 | XOU30658.1 |
| blaCMY-204 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | - | PV075195.1 | XOU30659.1 |
| blaCMY-205 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | - | PV075196.1 | XOU30660.1 |
| blaCMY-206 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | - | PV075197.1 | XOU30661.1 |
| blaCMY-207 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | - | PV075198.1 | XOU30662.1 |
| blaCMY-208 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter sp. | - | - | PV075199.1 | XOU30663.1 |
| blaCMY-211 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter sp. | - | - | PV075202.1 | XOU30666.1 |
| blaCMY-214 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter braakii | - | - | PV075205.1 | XOU30669.1 |
| blaCMY-215 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | - | PV075206.1 | XOU30670.1 |
| blaCMY-216 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter sp. | - | - | PV075207.1 | XOU30671.1 |
| blaCMY-217 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter sp. | - | - | PV075208.1 | XOU30672.1 |
| blaCMY-218 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Proteus mirabilis | - | - | PV088248.1 | XPD12780.1 |
| blaCMY-22 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Escherichia coli +1 | Michigan|United States | 2023 | DQ256079.1 | ABB72431.1 |
| blaCMY-224 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | - | PX230295.1 | XZP33677.1 |
| blaCMY-225 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Escherichia coli | - | - | PX410274.1 | YBW81179.1 |
| blaCMY-226 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Escherichia coli | - | - | PX915388.1 | YCQ72203.1 |
| blaCMY-227 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Escherichia coli | - | - | CEWPKE010000051.1 | CAR1538096.1 |
| blaCMY-28 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +15 | Escherichia coli | United States | 2021 | EF561644.1 | ABQ51091.1 |
| blaCMY-35 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | EF394371.1 | ABN51007.1 |
| blaCMY-43 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | FJ360626.1 | ACJ05361.1 |
| blaCMY-46 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, CEPHALOSPORIN +18 | Escherichia coli +2 | Portugal, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China | 2015, 2024 | FN556186.1 | CBH19182.1 |
| blaCMY-47 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | HM046998.2 | ADH82410.1 |
| blaCMY-48 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Citrobacter freundii | - | 2022 | HM569226.2 | ADP02979.1 |
| blaCMY-50 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +17 | Escherichia coli +1 | Portugal | 2015 | FN645444.1 | CBI75447.1 |
| blaCMY-51 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Citrobacter freundii +4 | Australia|Singapore|Turkey | 2021 | JQ733571.1 | AFK73431.1 |
| blaCMY-60 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | JF460794.1 | AEM97672.1 |
| blaCMY-61 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +12 | Escherichia coli +1 | - | 2024 | JF460795.1 | AEM97673.1 |
| blaCMY-62 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +12 | Escherichia coli | Tunisia | 2023 | JF460796.1 | AEM97674.1 |
| blaCMY-63 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | HQ650104.1 | AET07387.1 |
| blaCMY-64 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +14 | Escherichia coli | China | 2014 | HQ832678.1 | ADW84690.1 |
| blaCMY-72 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Citrobacter freundii +1 | China | 2015 | JX440352.1 | AFU25641.1 |
| blaCMY-73 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | GQ351345.1 | ACU00152.1 |
| blaCMY-75 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | JQ733572.1 | AFK73434.1 |
| blaCMY-76 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | JQ733573.1 | AFK73437.1 |
| blaCMY-77 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +12 | Citrobacter sp. W1065 +1 | South Africa | 2023 | JX440353.1 | AFU25644.1 |
| blaCMY-78 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | JQ733575.1 | AFK73443.1 |
| blaCMY-79 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +16 | Citrobacter freundii | East Africa|Uganda | 2024 | JQ733576.1 | AFK73446.1 |
| blaCMY-80 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | JQ733577.1 | AFK73449.1 |
| blaCMY-81 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | JQ733578.1 | AFK73452.1 |
| blaCMY-82 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KJ207203.1 | AHL39324.1 |
| blaCMY-84 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | JQ733579.1 | AFK73455.1 |
| blaCMY-85 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Citrobacter freundii | China | 2019 | KJ207202.1 | AHL39322.1 |
| blaCMY-86 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | - | KJ207204.1 | AHL39327.1 |
| blaCMY-87 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Klebsiella pneumoniae | - | - | AB699171.1 | BAL63057.1 |
| blaCMY-96 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | KC007362.1 | AFZ85212.1 |
| blaCMY-97 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | KC007363.1 | AFZ85213.1 |
| blaCMY-107 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, AMOXICILLIN +14 | Escherichia coli | - | 2010, 2015 | KR061886.1 | WP_032494240.1 |
| blaCMY-12 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | TICARCILLIN, CEPHALOSPORIN +13 | Proteus mirabilis +1 | Poland, Europe, Mexico|Mexico City | 2002, 2004, 2008, 2011, 2023 | Y16785.1 | CAA76382.1 |
| blaCMY-146 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | carbapenems, TICARCILLIN +11 | Escherichia coli | China|Guangzhou, China | 2023 | NG_052648.1 | WP_075985683.1 |
| blaCMY-156 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | 2020 | NG_056410.1 | WP_104009849.1 |
| blaCMY-158 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Escherichia coli | - | 2020 | NG_062242.1 | WP_122630836.1 |
| blaCMY-159 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Escherichia coli | - | 2020 | NG_062243.1 | WP_122630837.1 |
| blaCMY-166 | Card DatabaseReference Gene CatalogReslit | 4 | ceftazidime, cefotaxime +3 | Escherichia coli | Algeria | 2025 | NG_065863.1 | WP_148044407.1 |
| blaCMY-30 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | TICARCILLIN, CEPHALOSPORIN +15 | Escherichia coli +2 | Global | 2009, 2022 | EF685372.2 | ABS12249.1 |
| blaCMY-4 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 24 | carbapenems, cephalosporins +25 | Proteus mirabilis +14 | Poland, England|Wales, Europe, Algeria, India, Tunisia, Spain, California|Europe|North America|Republic of Congo, Kuwait, Bulgaria, Western Sweden, South Africa, Bulgaria|Europe, Kathmandu, Nepal, Africa | 1998, 1999, 2000, 2004, 2005, 2011, 2015, 2016, 2018, 2020, 2021, 2022, 2023, 2024, 2025 | Y15130.1 | CAA75402.1 |
| blaCMY-59 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 12 | TICARCILLIN, AMOXICILLIN +19 | Escherichia coli +6 | Iran, Czech Republic, Europe, Brazil, United States|India, Michigan|United States, South Africa, mid-Atlantic United States, Algeria | 2011, 2013, 2020, 2021, 2023, 2025 | AB587082.1 | BAJ17544.1 |
| blaCMY-5 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | cefoxitin, cefotaxime +14 | Escherichia coli +1 | - | 1999 | Y17716|Y17846 | CAB50867.1 |
| blaCMY-2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 442 | cephalosporins, cefoxitin +36 | Salmonella enterica serovar Typhimurium DT104 +112 | Iowa, Taiwan, Iowa|Missouri|North Carolina, Canada, United States, Pennsylvania, Alberta, Canada, Europe, northeastern United States, Singapore, France, Honduras, England|Wales, Northern Taiwan, United States|New Zealand, China, Wisconsin, Atlantic Canada, Eastern Europe|India|Latin America|Asia Pacific|North America|Western Europe, Korea, Spain, Mexico, Cleveland|Pittsburgh, Thailand|Denmark, Ontario, Japan, Ireland, Asia|Denmark|France, South China, Europe|Asia|North America|South America, India, Colombia, Netherlands, Dhaka, Bangladesh, United States|U.S.|France|Korea, Portugal, Switzerland, British Columbia, Brazil, Austria|Europe, Italy, South Korea, Middle East, central New York, New York, The Netherlands, Southern China, Iran, Argentina, USA, Norway, Denmark, United Kingdom, Sweden, Saudi Arabia, Southcentral Alaska, Germany, Tanzania, Tunisia, North America|US|Germany|Switzerland|Japan|China|Hong Kong|United Kingdom, Québec|Ontario|New Brunswick, Guangzhou, China|Guangzhou, Guadeloupe, Serbia, Saraburi Province, Thailand, Hong Kong, Alaska, Germany|Vietnam|Egypt, Asia|Latin America|Africa, Estonia, Vietnam, Senegal, Ecuador, North Florida|Florida, Egypt|Africa|Europe|Asia|Middle East|Indonesia|India|USA, North America|Washington, Cambodia, Southeastern Brazil, Netherlands|Brazil|Argentina, U.S. High-Plains|western Texas|eastern New Mexico, South Brazil, British Columbia|British Columbia, Canada, France|Spain, South Africa, Turkey, Port-Harcourt, Nigeria, Tuscany, Czech Republic, California|Arizona|South Carolina|Idaho|Maine, Shanghai, China, Europe|EU/EEA|China|Spain|USA|Denmark|Sweden|Belgium|Switzerland|Norway|Netherlands|Slovakia|Germany|Romania|Italy|Cyprus, Europe|EU|non-EU|non-Member State|China|Spain|USA|Finland|Germany|Norway|Switzerland|Netherlands, Europe|Italy, Northwest Spain, Yunnan Province, Australia|Paraguay|Japan|Brazil|Germany|United States|China|New Zealand|United Kingdom|Netherlands|France|Italy|Spain, North America, Costa Rica, Mexico|Mozambique, North America|turtle, Delhi, India, Uruguay, Europe|Canada, Japan|Osaka, Japan, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, Greece, Northern Californian|California, Alberta|Canada, Italy|Europe, Europe|Spain|Hungary|Germany|France|Belgium|Poland|United Kingdom|Denmark, Europe|Italy|United States|Switzerland|Canada|Germany|France|Spain|Netherlands|Denmark|Norway|Sweden|Portugal|Hungary|Romania|Czechia|Belgium|Ireland|Luxembourg|Austria|Finland|Estonia|Latvia|Lithuania|Slovenia|Croatia|Bulgaria|Iceland|United Kingdom|Turkey|South America|Vietnam|Poland|UK|Malta|Slovakia, Europe|Poland, Pakistan|Argentina, Europe|Germany, Texas, California|Europe|North America|Republic of Congo, Pakistan, Kingdom of Saudi Arabia, Thailand, Egypt, Australia|Singapore|Turkey, Malaysia, Europe|broiler production pyramid, Europe|Spain, Uruguay|Brazil, New York State, New Zealand, North Carolina|USA, Hangzhou, China, Victoria, Australia, Europe|Netherlands, Boston, MA|Orange, CA, Europe|EU|China|Portugal|Germany, South America|Brazil, Global, Georgia, USA|Georgia, North America|Asia|Europe|Middle East|Africa, Mid-Atlantic United States, Washington State, Philippines, South Australia|Australia, Abuja, Nigeria, Germany|Central Germany, Khon Kaen province, Thailand, Bulgaria, Europe|North America, Yangzhou, China, UK, Ontario, Canada, Belgium, China|Guangzhou, China, Anhui, China, Bangladesh, Portugal|United Kingdom, West Texas, USA, Algeria, Shenzhen, China|China, Finland, Mexico|Mexico City, Kenya, Tamaulipas, Mexico, Central Adriatic|Central Adriatic Sea, Quebec, Canada, Europe|Italy|Brazil|Czechia|Germany|Finland|Netherlands|Norway|Sweden, Denmark|Finland|Germany, Bangladesh|Brazil|Greece|Italy|Kenya|South Africa|Thailand|Uganda|Vietnam, Guangdong, China, Nile Delta region of Egypt, Poland, France|Germany|Netherlands|Norway|Spain|United Kingdom|Europe, Southeast Asia, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, Zimbabwe, Athens, GA, Indonesia, Kathmandu, Nepal, Northern Italy, Cameroon, Inner Mongolia|Inner Mongolia, China, Atlanta, Türkiye, Egypt|Northern Egyptian governorates of Kafr El-Sheikh and Dakahlia, Caspian Sea | 1996, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AF121212 | CAA62957.1 |
| blaCMY-6 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 20 | TICARCILLIN, AMOXICILLIN +23 | Escherichia coli +6 | United States, China, Gothenburg, Asia|Latin America|Africa, Kuwait, Italy, West Bengal, India, Europe|Asia|North America|Western and South-Eastern Asia, Pakistan|Karachi, Pakistan, Uruguay, Egypt, Pakistan | 1998, 2002, 2014, 2017, 2018, 2019, 2022, 2023, 2024, 2025 | AJ011293 | CAB36902.1 |
| bla_cmy-2 | Reslit | 3 | ceftriaxone, cefoxitin +2 | Salmonella enterica +2 | United States, Canada, USA|Australia|Canada|Japan|France|Madagascar|China|Thailand|Germany | 2002, 2008, 2017 | CP009409|CP009410|CP009411|CP009412|CP009413|CP009414 | - |
| blaCMY-7 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | TICARCILLIN, CEPHALOSPORIN +15 | Escherichia coli +1 | Norway, Kuwait | 2002, 2006, 2013, 2017, 2023 | AJ011291.1 | CAB36900.1 |
| blaCMY -2 | Reslit | 2 | ceftriaxone, ceftazidime +3 | Salmonella enterica serovar Typhimurium +3 | Taiwan, United Kingdom | 2003, 2018 | NCBI Short Read Archive under the BioProject PRJNA315192 | - |
| blaCMY | Reslit | 84 | ceftriaxone, cefoxitin +15 | Salmonella enterica serotype Newport +44 | United States, Canada, Washington|Alaska|New Jersey|Malaysia|Mexico|Israel, Europe, Japan, Nebraska|United States, New York, Southern Taiwan, Ecuador, Greece, North America|US|Germany|Switzerland|Japan|China|Hong Kong|United Kingdom, Pakistan|Thailand, Ethiopia, Libya, Norway, Mozambique, United States|Europe|China, Shanghai, China, Portugal, South Africa|various water sources, India, South Africa, Egypt, Nigeria, Western Cape, South Africa, California|Europe|North America|Republic of Congo, Mexico City, India|Malaysia|South China, Bangladesh, Romania|France, Europe|North America|Netherlands|Denmark|Pennsylvania|United States|France, Georgia, USA|Georgia, Europe|USA|Portugal|Germany|Australia|China|India|Pakistan|Sweden|Colorado, France, Iran, China|global, Ontario, Canada, Western Province of Sri Lanka, Guizhou, China, Canada|Newfoundland, Canada, Argentina, Croatia, Spain, China, Taiwan, Calgary, Canada|Calgary, Alberta, Canada, Algeria, India|Delhi NCR, China|Thailand|USA|Spain|Norway|Japan|Vietnam|Hong Kong, Pakistan | 2003, 2005, 2006, 2008, 2009, 2010, 2012, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | X91840 | - |
| blaCMY-13 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | cefotaxime, ceftazidime +17 | Escherichia coli | - | 2004 | AY339625 | AAQ16660.2 |
| blaCMY-14 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | cephalosporins, penicillin +13 | Proteus mirabilis +1 | Poland, Europe, Italy|Israel|Poland | 2004, 2011, 2013 | AJ555823|AJ555825 | CAD88479.1 |
| blaCMY-15 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | cephalosporins, penicillin +15 | Proteus mirabilis +2 | Poland, Europe, Italy|Israel|Poland | 2004, 2008, 2011, 2013 | AJ555823|AJ555825 | CAD88477.1 |
| bla_CMY-2 | Reslit | 6 | ceftriaxone, meropenem +4 | Salmonella enterica +5 | New York, North Carolina|China, Germany|Kosovo|Ukraine|Afghanistan, South Korea, California|Arizona|South Carolina|Idaho|Maine | 2005, 2017, 2020, 2023 | CP011061.1 | - |
| blaCMY-16 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 17 | penicillin, cephalosporins +22 | Proteus mirabilis +9 | Italy, Europe, Belgium, Tunisia, Germany, Romania, Europe|Asia|North America|Western and South-Eastern Asia, Pakistan|Karachi, Pakistan, Europe|Italy | 2006, 2011, 2012, 2016, 2018, 2020, 2022, 2023, 2025 | AJ781421 | CAH03679.1 |
| blaCMY-18 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | 2006 | AY743434.1 | AAU95778.1 |
| blaCMY-21 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | 2006 | DQ139328.1 | AAZ66866.1 |
| blaCMY-23 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Salmonella enterica subsp. enterica serovar Senftenberg +2 | United States | 2007 | DQ463751.1 | ABF06441.1 |
| bla_cmy | Reslit | 1 | cefoxitin | Escherichia coli | Calgary Health Region | 2007 | NC_002655 | - |
| blaCMY-24 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | 2007 | EF415650.1 | ABN69070.1 |
| blaCMY-26 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ampicillin, cephalothin +15 | Klebsiella oxytoca | Japan | 2007 | AB300358 | BAF56185.1 |
| blaCMY-31 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Klebsiella pneumoniae | - | 2008 | EF622224.1 | ABR18736.1 |
| blaCMY-20 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | 2008 | AY960293.2 | AAX58682.2 |
| blaCMY-65 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, AMOXICILLIN +12 | Citrobacter sp. 913 +1 | China | 2008, 2015, 2021 | JF780936 | AEI52842.1 |
| blaCMY-38 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | cephalosporins, TICARCILLIN +13 | Proteus mirabilis +1 | Poland, Europe, Mexico|Mexico City | 2008, 2011, 2023 | AM931008 | CAP60699.1 |
| blaCMY-37 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Citrobacter freundii | Global | 2008, 2022 | AB280919.1 | BAF36388.1 |
| blaCMY-36 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Klebsiella pneumoniae | - | 2009 | EU331426.1 | ABY58049.1 |
| blaCMY-41 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +14 | Citrobacter freundii +1 | China | 2009, 2014 | AB429270.1 | BAG14343.1 |
| blaCMY-29 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Escherichia coli | Global | 2009, 2022 | EF685371.2 | ABS12248.1 |
| blaCMY-33 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | cefepime, TICARCILLIN +13 | Escherichia coli | - | 2009, 2015 | EU496816|FJ437066 | ACA97847.1 |
| blaCMY-44 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | cefepime, TICARCILLIN +11 | Escherichia coli | - | 2009 | EU496816|FJ437066 | ACJ65711.1 |
| blaCMY-25 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | cefotaxime, ceftazidime +12 | Escherichia coli +1 | Spain | 2010 | EU515249|EU515250|EU515251 | ACA30420.1 |
| blaCMY-27 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | cefotaxime, ceftazidime +12 | Escherichia coli +1 | Spain | 2010 | EU515249|EU515250|EU515251 | ACA30421.1 |
| blaCMY-40 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | cefotaxime, ceftazidime +12 | Escherichia coli +1 | Spain | 2010 | EU515249|EU515250|EU515251 | ACA30422.1 |
| blaCMY-32 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, CEPHALOSPORIN +16 | Escherichia coli +1 | Cleveland|Pittsburgh | 2009, 2010, 2015 | EU496815.1 | ACA97846.1 |
| blaCMY-189 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Citrobacter freundii | - | 1990 | D13207.1 | BAA02494.1 |
| blaCMY-49 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Citrobacter freundii +1 | China | 2010, 2025 | GQ402541.1 | ACV32310.1 |
| bla(CMY-2) | Reslit | 6 | cefoxitin, cefotaxime +5 | Escherichia coli +3 | Kinki region of Japan|Japan, China, Europe, South Korea, Korea, Finland | 2010, 2018, 2021 | KT074362|KY612498|KY612499|KY612500 | - |
| bla(CMY-8) | Reslit | 1 | cefoxitin, cefotaxime +2 | Klebsiella pneumoniae | Kinki region of Japan|Japan | 2010 | - | - |
| blaCMY-42 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 36 | TICARCILLIN, CEPHALOSPORIN +25 | Escherichia coli +4 | Nepal, United States|Guatemala|India|Jordan|Lebanon|France|Poland|Romania|Russia, Egypt, India, Norway|Asia, Asia|Latin America|Africa, Cambodia, Switzerland, Tanzania, Italy|Far East countries, Myanmar, Norway, Northwest Spain, Oman, Europe, Delhi, India, Vietnam, Global, North America|Asia|Europe|Middle East|Africa, Caribbean, South-West Nigeria, Australia, Bangladesh, Southeast Asia, South Korea | 2011, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | HM146927.1 | ADM21467.1 |
| blaCMY-45 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | cephalosporins, penicillin +13 | Proteus mirabilis | Europe | 2011 | FN546177|FR716828|FM995219 | CBB16411.1 |
| blaCMY-58 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | cephalosporins, TICARCILLIN +12 | E. coli +4 | Belgium, Norway | 2011, 2017 | HQ185697 | ADY19254.1 |
| bla(CMY-6) | Reslit | 2 | cefoxitin, ceftriaxone +3 | Escherichia coli +2 | China | 2011, 2022 | PRJNA875629 | - |
| blaCMY-34 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +13 | Citrobacter freundii +1 | Europe | 2012, 2025 | EF394370.1 | ABN51006.1 |
| blaCMY-53 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | 2012 | HQ336940.1 | ADQ38362.1 |
| blaCMY-54 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Escherichia coli | Global | 2013, 2022 | HM544039.1 | ADK55604.1 |
| blaCMY-55 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | 2013 | HM544040.1 | ADK55605.1 |
| blaCMY-56 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Klebsiella pneumoniae | - | 2013 | HQ322613.1 | ADT91162.1 |
| blaCMY-57 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | 2013 | HQ285243.1 | ADP37961.1 |
| blaCMY-94 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | 2013 | JX514368.1 | AGC54798.1 |
| blaCMY-95 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | 2013 | JX514369.1 | AGC54799.1 |
| blaCMY-99 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | cefoxitin, cefotaxime +16 | Proteus mirabilis | Bulgaria, Global | 2014, 2022 | KF305673 | AGU59995.1 |
| blaCMY-89 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | 2014 | HE819403.1 | CCK86742.1 |
| blaCMY-90 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | 2014 | HE819404.1 | CCK86743.1 |
| blaCMY-108 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | 2014 | KF564648.1 | AGZ20169.1 |
| blaCMY-110 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | 2014 | AB872957.1 | BAO05497.1 |
| blaCMY-69 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | ceftazidime, TICARCILLIN +17 | Escherichia coli | - | 2014, 2020 | JX049132.1 | AGE45504.1 |
| blaCMY-100 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | 2014 | KF526113.1 | AHA80101.1 |
| blaCMY-101 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | TICARCILLIN, CEPHALOSPORIN +13 | Escherichia coli +7 | Australia|Singapore|Turkey, South Africa, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China | 2014, 2021, 2023, 2024 | KF526114.1 | AHA80102.1 |
| blaCMY-102 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +12 | Escherichia coli | South Korea | 2014, 2025 | KF526115.1 | AHA80103.1 |
| blaCMY-103 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | 2014 | KF526116.1 | AHA80104.1 |
| blaCMY-66 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | 2015 | JN714478.1 | AEZ49849.1 |
| blaCMY-67 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | 2015 | JQ711185.1 | AFK08541.1 |
| blaCMY-68 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | 2015 | JN714480.1 | AEZ49855.1 |
| blaCMY-70 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Citrobacter braakii +1 | Lebanon | 2015, 2018 | JX440350.1 | AFU25635.1 |
| blaCMY-71 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | 2015 | JQ711184.1 | AFK08538.1 |
| blaCMY-74 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter braakii | - | 2015 | JX440349.1 | AFU25632.1 |
| blaCMY-83 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, CEPHALOSPORIN +15 | Citrobacter braakii +2 | Poland | 2015, 2020, 2023 | JX440351.1 | AFU25638.1 |
| blaCMY-93 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | 2015 | KF992025.1 | AHM76768.1 |
| blaCMY-111 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Serratia marcescens +3 | Brazil | 2015, 2021 | KJ155695.1 | AHW47897.1 |
| blaCMY-134 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | cefoxitin, cefotaxime +13 | Escherichia coli | Netherlands | 2015 | KP860987 | AKA60779.1 |
| CMY | Reslit | 7 | cefoxitin, cefotaxime +7 | Klebsiella pneumoniae +6 | Taiwan, New York|Washington, Delhi, India, China, Japan, Hungary | 2015, 2017, 2019, 2023, 2024 | NCBI BioProject PRJNA353421 | - |
| blaCMY-130 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | 2015 | KP207589.1 | AKI06385.1 |
| blaCMY-135 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | 2015 | KP981366.1 | AKP17985.1 |
| blaCMY-39 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Citrobacter freundii | - | 2015 | AB372224.1 | BAF95726.1 |
| CMY/LAT/ACT/MIR | Reslit | 1 | ceftazidime, ceftriaxone +1 | Proteus mirabilis | Italy | 2017 | - | - |
| blaCMY-220 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | 2018 | DAFMKX010000034.1 | HBN2680090.1 |
| blaCMY-221 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | 2018 | DAFMKV010000031.1 | HBN2659835.1 |
| blaCMY-222 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | 2018 | DAFMLC010000012.1 | HBN2683657.1 |
| blaCMY-223 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | 2018 | DAFMLA010000036.1 | HBN2669143.1 |
| blaCMY-136 | Card DatabaseReference Gene CatalogReslit | 3 | CEPHALOSPORIN, ceftazidime +2 | Escherichia coli +1 | Global | 2019, 2022 | MG844436.1 | AVR61040.1 |
| blaCMY-150 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +11 | Citrobacter freundii | - | 2020 | QCWX01000028.1 | PUU64961.1 |
| blaCMY–2 | Reslit | 6 | cefoxitin, cefotaxime +7 | Escherichia coli O80:H26 +5 | Brazil, Northern Californian|California, Spain|Asturias, Northern Spain, New Zealand | 2020, 2021, 2022 | CP043217|CP043221|CP043222|CP043224|CP043214|CP043215|CP043216|SRP219110|PRJNA560883 | - |
| blaCMY-172 | Card DatabaseReference Gene CatalogReslit | 5 | ceftazidime avibactam, CEPHALOSPORIN +3 | Klebsiella pneumoniae +1 | China, Global | 2022, 2023 | CP058230|MT752965 | QLH93380.1 |
| blaCMY-II | Reslit | 1 | ampicillin | Escherichia coli | Northern Lebanon | 2021 | - | - |
| blaCMY-17 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | 2020 | AY513266.1 | AAS13399.1 |
| bla_CMY-6 | Reslit | 2 | cephalosporins | Enterobacterales +1 | Vietnam, Argentina | 2021, 2024 | AP018565|AP018566|AP018567|AP018568|AP018571|AP018572|AP018577|AP018578|AP018579|AP018580|AP018581|AP018582|AP018583|AP018584|CP021952|CP040884|CP041930|CP043383|CP034846|CP026053|CP041177|PRJDB6655 | - |
| blaCMY/ACT | Reslit | 1 | cephalosporins, carbapenems +1 | Cedecea neteri SSMD04 +2 | Europe|global | 2021 | CP009451.1|CP009458.1|CP009459.1|CP011077.1|NZ_CP009451.1|NZ_CP011077.1 | - |
| CMY-II | Reslit | 1 | cephalosporins | Escherichia coli | India|Ghana|Nepal|Laos | 2022 | - | - |
| blaCMY-like | Reslit | 1 | ampicillin, amoxicillin clavulanic acid +4 | Escherichia coli | Egypt | 2022 | - | - |
| bla(CMY) | Reslit | 2 | ampicillin, ceftazidime avibactam | Escherichia coli +1 | Egypt, China | 2023, 2024 | CP064660|CP061747|MT129534|CP049602|CP024814 | - |
| blaCMY-178 | Card DatabaseReference Gene CatalogReslit | 3 | ceftazidime avibactam, CEPHALOSPORIN | Escherichia coli +1 | China | 2023, 2024 | CP058226|CP058227|CP058228|CP058229|CP058230|OK554431|CP097170|CP097171|CP097172 | UDF87831.1 |
| blaCMY - 100 | Reslit | 1 | ceftazidime, cefotaxime | Citrobacter freundii | Finland | 2023 | - | - |
| blaBIL-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | penicillin, cephalosporins +10 | Escherichia coli | Mexico|Mexico City | 1994, 2023 | X74512.1 | CAA52618.1 |
| blaCMY-185 | Card DatabaseReference Gene CatalogReslit | 3 | ceftazidime avibactam, TANIBORBACTAM +1 | Escherichia coli | - | 2024 | 8JB7|8JB8 | WCB91330.1 |
| bla(CMY-145) | Reslit | 1 | cephalosporins | Escherichia coli | Germany|Ukraine | 2024 | PMC11539215 | - |
| blaCMY-192 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime avibactam, CEFTAZIDIME+AVIBACTAM +12 | Escherichia coli | China | 2024 | CP151643|CP151644|CP151645|CP151646|PP693800 | WZW61258.1 |
| blaCMY-3 | Reslit | 2 | cephalosporins, amoxicillin +6 | Citrobacter sp. +2 | Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, France | 1998, 2024 | CP038466.1|CP072345|CP072346|CP072347|CP072348|CP072349|CP072350|CP072351|CP072352|CP072353|CP072354 | - |
| CMY/MOX | Reslit | 1 | ceftriaxone | Escherichia coli +1 | New York City | 2025 | - | - |
| blaCMY-219 | Reference Gene Catalog | 1 | AVIBACTAM, CEPHALOSPORIN | Escherichia coli | - | 2026 | PV268422.1 | XQH02529.1 |
| blaCMY-2b | ResFinder Database | 1 | TICARCILLIN, AMOXICILLIN +9 | Salmonella enterica subsp. enterica serovar Senftenberg | - | 1997 | U77414 | - |
| blaCMY-98 | Card DatabaseResFinder Database | 3 | UNKNOWN BETA-LACTAM | Citrobacter freundii | - | - | KC603538 | AGH70380.1 |
Carbapenem Resistance in Escherichia coli Associated with Plasmid-Determined CMY-4 beta-lactamase Production and Loss of an Outer Membrane Protein
The study identifies CMY-4, a plasmid-encoded class C beta-lactamase, as a key mediator of carbapenem resistance in E. coli, along with the loss of an outer membrane protein.
Characterization and nucleotide sequence of a Klebsiella oxytoca cryptic plasmid encoding a CMY-type beta-lactamase: confirmation that the plasmid-mediated cephamycinase originated from the Citrobacter freundii AmpC beta-lactamase.
The study characterizes a CMY-5 beta-lactamase encoded by a cryptic plasmid in Klebsiella oxytoca, which confers resistance to extended-spectrum beta-lactams.
Characterization and nucleotide sequence of a Klebsiella oxytoca cryptic plasmid encoding a CMY-type beta-lactamase: confirmation that the plasmid-mediated cephamycinase originated from the Citrobacter freundii AmpC beta-lactamase.
Characterization and nucleotide sequence of a Klebsiella oxytoca cryptic plasmid encoding a CMY-type beta-lactamase: confirmation that the plasmid-mediated cephamycinase originated from the Citrobacter freundii AmpC beta-lactamase.
Characterization and nucleotide sequence of a Klebsiella oxytoca cryptic plasmid encoding a CMY-type beta-lactamase: confirmation that the plasmid-mediated cephamycinase originated from the Citrobacter freundii AmpC beta-lactamase.
Characterization and nucleotide sequence of a Klebsiella oxytoca cryptic plasmid encoding a CMY-type beta-lactamase: confirmation that the plasmid-mediated cephamycinase originated from the Citrobacter freundii AmpC beta-lactamase.
Occurrence and detection of AmpC beta-lactamases among Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates at a veterans medical center.
The study identifies the presence of AmpC beta-lactamases in E. coli, K. pneumoniae, and P. mirabilis isolates, highlighting the importance of detecting these enzymes for effective antimicrobial treatment.
Animal and human multidrug-resistant, cephalosporin-resistant salmonella isolates expressing a plasmid-mediated CMY-2 AmpC beta-lactamase.
The study identifies the plasmid-mediated CMY-2 AmpC beta-lactamase as a cause of multidrug-resistant, cephalosporin-resistant Salmonella isolates in both animals and humans.
Dissemination of CTX-M-3 and CMY-2 beta-lactamases among clinical isolates of Escherichia coli in southern Taiwan.
The study identifies CTX-M-3 and CMY-2 beta-lactamases as significant contributors to beta-lactam resistance in clinical isolates of Escherichia coli in southern Taiwan.
Evidence for transfer of CMY-2 AmpC beta-lactamase plasmids between Escherichia coli and Salmonella isolates from food animals and humans.
The study identifies the CMY-2 AmpC beta-lactamase plasmid as a significant contributor to cephalosporin resistance in Escherichia coli and Salmonella isolates from food animals and humans, highlighting its potential for cross-species transmission.
Origin and evolution of the AmpC beta-lactamases of Citrobacter freundii.
Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella strains isolated in the United States between 1996 and 1998.
The study identifies the CMY-2 beta-lactamase as the primary cause of expanded-spectrum cephalosporin resistance in Salmonella strains isolated in the United States between 1996 and 1998.
Development of a sensitive and specific enzyme-linked immunosorbent assay for detecting and quantifying CMY-2 and SHV beta-lactamases.
The study developed sensitive and specific ELISAs for detecting and quantifying CMY-2 and SHV beta-lactamases, demonstrating their effectiveness in identifying these resistance enzymes in clinical isolates.
Unusual Salmonella enterica serotype Typhimurium isolate producing CMY-7, SHV-9 and OXA-30 beta-lactamases.
Unusual Salmonella enterica serotype Typhimurium isolate producing CMY-7, SHV-9 and OXA-30 beta-lactamases.
Unusual Salmonella enterica serotype Typhimurium isolate producing CMY-7, SHV-9 and OXA-30 beta-lactamases.
Occurrence and characterization of resistance to extended-spectrum cephalosporins mediated by beta-lactamase CMY-2 in Salmonella isolated from food-producing animals in Canada.
The study identifies the beta-lactamase CMY-2 as a mediator of resistance to extended-spectrum cephalosporins in Salmonella isolates from food-producing animals in Canada.
Characterization of CMY-type beta-lactamases in clinical strains of Proteus mirabilis and Klebsiella pneumoniae isolated in four hospitals in the Paris area.
Characterization of CMY-type beta-lactamases in clinical strains of Proteus mirabilis and Klebsiella pneumoniae isolated in four hospitals in the Paris area.
Characterization of CMY-type beta-lactamases in clinical strains of Proteus mirabilis and Klebsiella pneumoniae isolated in four hospitals in the Paris area.
Characterization of CMY-type beta-lactamases in clinical strains of Proteus mirabilis and Klebsiella pneumoniae isolated in four hospitals in the Paris area.
Occurrence of newer beta-lactamases in Klebsiella pneumoniae isolates from 24 U.S. hospitals.
The study identified several beta-lactamases, including bla DHA-1, bla ACT-1, bla FOX-5, bla CMY-2, and bla KPC-2, in Klebsiella pneumoniae isolates from 24 U.S. hospitals. These enzymes confer resistance to various beta-lactam antibiotics.
Molecular characterization of cephalosporin-resistant Salmonella enterica serotype Newport isolates from animals in Pennsylvania.
The study identifies the bla CMY-2 gene as the primary cause of cephalosporin resistance in Salmonella enterica serotype Newport isolates from Pennsylvania, highlighting its plasmid-mediated nature and association with multidrug resistance.
Emergence of ceftriaxone-resistant Salmonella isolates and rapid spread of plasmid-encoded CMY-2-like cephalosporinase, Taiwan.
The study identifies the emergence of ceftriaxone-resistant Salmonella isolates carrying the plasmid-encoded CMY-2-like cephalosporinase, highlighting its rapid spread among various bacterial species in Taiwan.
Association between handling of pet treats and infection with Salmonella enterica serotype newport expressing the AmpC beta-lactamase, CMY-2.
The study identifies the plasmid-encoded AmpC beta-lactamase CMY-2 as the resistance mechanism in Salmonella enterica serotype Newport strains associated with pet treats, leading to resistance against multiple beta-lactam antibiotics.
Cephalosporin-resistant Escherichia coli among summer camp attendees with salmonellosis.
The study identified CTX-M-9, CMY-2, and TEM-1 beta-lactamase genes in extended-spectrum cephalosporin-resistant Escherichia coli (ESCREC) isolates from a summer camp outbreak. These genes conferred resistance to various β-lactam antibiotics.
Characterization of Salmonella enterica serotype newport isolated from humans and food animals.
The study identifies the bla CMY gene as responsible for resistance to ceftiofur and decreased susceptibility to ceftriaxone in Salmonella enterica serotype Newport MDR-AmpC isolates.
Variety of beta-lactamases produced by amoxicillin-clavulanate-resistant Escherichia coli isolated in the northeastern United States.
The study identified various beta-lactamases, including TEM-type, CMY-2, and OXA-type, in amoxicillin-clavulanate-resistant Escherichia coli isolates. Notably, two isolates harbored inhibitor-resistant TEM enzymes (TEM-34 and TEM-122) that conferred resistance to amoxicillin-clavulanate.
CTX-M and plasmid-mediated AmpC-producing Enterobacteriaceae Singapore.
The study identifies various CTX-M and plasmid-mediated AmpC beta-lactamase genes in Enterobacteriaceae isolates from Singapore, highlighting the emergence of these resistance mechanisms in the region.
DNA sequence analysis of regions surrounding blaCMY-2 from multiple Salmonella plasmid backbones.
The study characterizes the blaCMY-2 gene, which confers resistance to cephalosporins, and analyzes its surrounding regions in multiple Salmonella plasmid backbones.
CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid.
The study identifies CMY-13, a novel inducible cephalosporinase encoded by a plasmid in Escherichia coli, which confers resistance to multiple beta-lactam antibiotics.
CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid.
CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid.
CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid.
CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid.
In vivo acquisition of high-level resistance to imipenem in Escherichia coli.
The study identifies the plasmid-mediated cephalosporinase blaCMY-2 and a 2-bp deletion in the ompF gene as mechanisms of high-level imipenem resistance in Escherichia coli.
Pediatric infection due to multiresistant Salmonella enterica serotype Infantis in Honduras.
The study reports the first detection of bla CTX-M-15 in Salmonella and identifies multiple beta-lactamase genes (bla TEM-1b, bla SHV-5, bla CTX-M-15, and bla CMY-2) in a multidrug-resistant Salmonella enterica serotype Infantis isolate from Honduras.
Four variants of the Citrobacter freundii AmpC-Type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
The study identifies four variants of the Citrobacter freundii AmpC-type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
Four variants of the Citrobacter freundii AmpC-Type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
The study identifies four variants of the Citrobacter freundii AmpC-type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
Four variants of the Citrobacter freundii AmpC-Type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
The study identifies four variants of the Citrobacter freundii AmpC-type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
Four variants of the Citrobacter freundii AmpC-Type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
The study identifies four variants of the Citrobacter freundii AmpC-type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
Four variants of the Citrobacter freundii AmpC-Type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
Four variants of the Citrobacter freundii AmpC-Type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
Four variants of the Citrobacter freundii AmpC-Type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
Four variants of the Citrobacter freundii AmpC-Type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
Four variants of the Citrobacter freundii AmpC-Type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
Four variants of the Citrobacter freundii AmpC-Type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
Four variants of the Citrobacter freundii AmpC-Type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
Four variants of the Citrobacter freundii AmpC-Type cephalosporinases, including novel enzymes CMY-14 and CMY-15, in a Proteus mirabilis clone widespread in Poland.
Acquisition of resistance to extended-spectrum cephalosporins by Salmonella enterica subsp. enterica serovar Newport and Escherichia coli in the turkey poult intestinal tract.
The study demonstrates that the 72-MDa conjugative plasmid carrying the cmy-2 gene can be transferred from Escherichia coli to Salmonella enterica subsp. enterica serovar Newport, leading to resistance against extended-spectrum cephalosporins and other antibiotics.
The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen.
The study identifies multiple antimicrobial resistance genes on plasmids pSC138 and pSCV50 in Salmonella enterica serovar Choleraesuis SC-B67, including blaTEM-1, blaCMY-2, tetRA, strA, aadA2, sulI, sulII, catI, cmlA, aph, sat, mef, mer, ebr, qac, and blaTEM-67. Additionally, mutations in the chromosomal genes gyrA and parC, along with the inactivation of acrR, contribute to ciprofloxacin resistance.
Characterization of AmpC-mediated resistance in clinical Salmonella isolates recovered from humans during the period 1992 to 2003 in England and Wales.
The study identified bla DHA-1, bla CMY-2, and bla CMY-4 genes in Salmonella isolates, which confer resistance to various β-lactam antibiotics. These genes were found in plasmids and were transferable, indicating potential for spread.
Characterization of AmpC-mediated resistance in clinical Salmonella isolates recovered from humans during the period 1992 to 2003 in England and Wales.
The study identified bla DHA-1, bla CMY-2, and bla CMY-4 genes in Salmonella isolates, which confer resistance to various β-lactam antibiotics. These genes were found in plasmids and were transferable, indicating potential for spread.
Practical methods using boronic acid compounds for identification of class C beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli.
The study identifies and characterizes several plasmid-mediated class C beta-lactamases, including CMY-2, CMY-8, CMY-9, FOX-5, MOX-1, ACT-1, and LAT-1, which confer resistance to ceftazidime and cefotaxime in Escherichia coli and Klebsiella pneumoniae. The researchers developed practical methods using boronic acid compounds, such as 3-aminophenylboronic acid (APB), to detect these beta-lactamases.
Outbreak of dysentery associated with ceftriaxone-resistant Shigella sonnei: First report of plasmid-mediated CMY-2-type AmpC beta-lactamase resistance in S. sonnei.
The study reports the first case of plasmid-mediated CMY-2-type AmpC beta-lactamase resistance in Shigella sonnei, which conferred resistance to ceftriaxone.
Cephalosporin and ciprofloxacin resistance in Salmonella, Taiwan.
The study identified bla CMY-2 as a key determinant of extended-spectrum cephalosporin resistance in Salmonella isolates from Taiwan, along with mutations in gyrA and parC contributing to ciprofloxacin resistance.
Ceftriaxone Resistance of Nontyphoidal Salmonella enterica Isolates in Northern Taiwan Attributable to Production of CTX-M-14 and CMY-2 beta-lactamases.
The study identifies CTX-M-14 and CMY-2 beta-lactamases as the primary causes of ceftriaxone resistance in nontyphoidal Salmonella enterica isolates in Northern Taiwan.
Efficacy of cefepime and imipenem in experimental murine pneumonia caused by porin-deficient Klebsiella pneumoniae producing CMY-2 beta-Lactamase.
The study characterizes the CMY-2 beta-lactamase in porin-deficient Klebsiella pneumoniae, demonstrating its role in resistance to cefepime and imipenem.
Ceftiofur-resistant Salmonella strains isolated from dairy farms represent multiple widely distributed subtypes that evolved by independent horizontal gene transfer.
The study identified bla CMY-2 as a key gene conferring resistance to ceftiofur and ceftriaxone in Salmonella strains isolated from dairy farms, highlighting its role in the spread of antimicrobial resistance.
Beta-lactam resistance and Enterobacteriaceae, United States.
The study identified bla CMY genes as the primary mechanism of extended-spectrum cephalosporin resistance in non-Typhi Salmonella, including the first report of bla CMY in E. coli O157:H7. It also detected bla SHV in a Salmonella isolate.
CMY-16, a novel acquired AmpC-type beta-lactamase of the CMY/LAT lineage in multifocal monophyletic isolates of Proteus mirabilis from northern Italy.
The study identifies CMY-16, a novel acquired AmpC-type beta-lactamase in Proteus mirabilis isolates from northern Italy, which confers resistance to penicillins, cephalosporins, and aztreonam.
CMY-16, a novel acquired AmpC-type beta-lactamase of the CMY/LAT lineage in multifocal monophyletic isolates of Proteus mirabilis from northern Italy.
CMY-16, a novel acquired AmpC-type beta-lactamase of the CMY/LAT lineage in multifocal monophyletic isolates of Proteus mirabilis from northern Italy.
CMY-16, a novel acquired AmpC-type beta-lactamase of the CMY/LAT lineage in multifocal monophyletic isolates of Proteus mirabilis from northern Italy.
CMY-16, a novel acquired AmpC-type beta-lactamase of the CMY/LAT lineage in multifocal monophyletic isolates of Proteus mirabilis from northern Italy.
Prevalence of plasmid-mediated AmpC beta-lactamases in Escherichia coli and Klebsiella pneumoniae in Korea.
Prevalence of plasmid-mediated AmpC beta-lactamases in Escherichia coli and Klebsiella pneumoniae in Korea.
Prevalence of plasmid-mediated AmpC beta-lactamases in Escherichia coli and Klebsiella pneumoniae in Korea.
Prevalence of plasmid-mediated AmpC beta-lactamases in Escherichia coli and Klebsiella pneumoniae in Korea.
New plasmid-mediated AmpC beta-lactamase (CMY-21) in Escherichia coli isolated in the UK.
New plasmid-mediated AmpC beta-lactamase (CMY-21) in Escherichia coli isolated in the UK.
New plasmid-mediated AmpC beta-lactamase (CMY-21) in Escherichia coli isolated in the UK.
New plasmid-mediated AmpC beta-lactamase (CMY-21) in Escherichia coli isolated in the UK.
Characterisation of CTX-M and AmpC genes in human isolates of Escherichia coli identified between 1995 and 2003 in England and Wales.
Prevalence of newer beta-lactamases in gram-negative clinical isolates collected in the United States from 2001 to 2002.
The study identified various beta-lactamases including SHV, CTX-M, FOX, CMY, DHA, and KPC, which confer resistance to multiple beta-lactam antibiotics in gram-negative clinical isolates in the United States.
Identification of specific gene sequences conserved in contemporary epidemic strains of Salmonella enterica.
The study identifies specific gene sequences conserved in contemporary epidemic strains of Salmonella enterica, highlighting the role of mobile genetic elements and the presence of the bla CMY-2 gene in cephalosporin-resistant MDR Salmonella enterica serovar Newport.
Wide geographic spread of diverse acquired AmpC beta-lactamases among Escherichia coli and Klebsiella spp. in the UK and Ireland.
Wide geographic spread of diverse acquired AmpC beta-lactamases among Escherichia coli and Klebsiella spp. in the UK and Ireland.
Wide geographic spread of diverse acquired AmpC beta-lactamases among Escherichia coli and Klebsiella spp. in the UK and Ireland.
Population-based laboratory surveillance for AmpC beta-lactamase-producing Escherichia coli, Calgary.
The study identified bla_cmy genes encoding CMY-2 beta-lactamase in AmpC beta-lactamase-producing E. coli isolates, highlighting their emergence as a community pathogen causing urinary tract infections in older women.
Emerging problems with plasmid-mediated DHA and CMY AmpC beta-lactamases in Enterobacteriaceae in Singapore.
Emerging problems with plasmid-mediated DHA and CMY AmpC beta-lactamases in Enterobacteriaceae in Singapore.
Emerging problems with plasmid-mediated DHA and CMY AmpC beta-lactamases in Enterobacteriaceae in Singapore.
Emerging problems with plasmid-mediated DHA and CMY AmpC beta-lactamases in Enterobacteriaceae in Singapore.
Multiplex Asymmetric PCR-Based Oligonucleotide Microarray for Detection of Drug Resistance Genes Containing Single Mutations in Enterobacteriaceae
The study developed a multiplex asymmetric PCR-based microarray for detecting drug resistance genes containing single mutations in Enterobacteriaceae, focusing on beta-lactamase genes such as bla SHV, bla TEM, bla CTX-M-3, bla CTX-M-9, bla DHA-1, bla CMY-2, bla MOX-1, bla ACC-1, bla FOX-5, and bla MIR-1. It also identified six point mutations in the bla SHV gene.
Zoo animals as reservoirs of gram-negative bacteria harboring integrons and antimicrobial resistance genes.
The study identified various antimicrobial resistance genes in gram-negative bacteria isolated from zoo animals, including bla TEM-1, bla OXY-2, bla SHV-36, bla CTX-M-2, bla CMY-26, qnrB, qnrS, and aac(6')-Ib-cr.
Zoo animals as reservoirs of gram-negative bacteria harboring integrons and antimicrobial resistance genes.
Zoo animals as reservoirs of gram-negative bacteria harboring integrons and antimicrobial resistance genes.
Zoo animals as reservoirs of gram-negative bacteria harboring integrons and antimicrobial resistance genes.
Zoo animals as reservoirs of gram-negative bacteria harboring integrons and antimicrobial resistance genes.
Plasmid-mediated AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes: prevalence at a Swiss university hospital and occurrence of the different molecular types in Switzerland.
Plasmid-mediated AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes: prevalence at a Swiss university hospital and occurrence of the different molecular types in Switzerland.
Plasmid-mediated AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes: prevalence at a Swiss university hospital and occurrence of the different molecular types in Switzerland.
Plasmid-mediated AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes: prevalence at a Swiss university hospital and occurrence of the different molecular types in Switzerland.
CMY-20, a novel AmpC-type beta-lactamase from South African clinical Escherichia coli isolates.
CMY-20, a novel AmpC-type beta-lactamase from South African clinical Escherichia coli isolates.
CMY-20, a novel AmpC-type beta-lactamase from South African clinical Escherichia coli isolates.
CMY-20, a novel AmpC-type beta-lactamase from South African clinical Escherichia coli isolates.
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
The study identifies various beta-lactamase genes (bla CMY-2, bla CMY-23, bla SHV-12, bla SHV-30, bla OXA-1, bla OXA-9) and a qnrB2 gene associated with reduced susceptibility to quinolones and extended-spectrum cephalosporins in Salmonella isolates. Additionally, mutations in gyrA and parC genes contribute to quinolone resistance.
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
The study identifies various beta-lactamase genes (bla CMY-2, bla CMY-23, bla SHV-12, bla SHV-30, bla OXA-1, bla OXA-9) and a qnrB2 gene associated with reduced susceptibility to quinolones and extended-spectrum cephalosporins in Salmonella isolates. Additionally, mutations in gyrA and parC genes contribute to quinolone resistance.
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
Human multidrug-resistant Salmonella Newport infections, Wisconsin, 2003-2005.
The study identifies the blaCMY-2 gene as a key factor in ceftriaxone resistance among multidrug-resistant Salmonella Newport isolates in Wisconsin, highlighting its potential for spread via plasmid transfer.
High-level carbapenem resistance in a Citrobacter freundii clinical isolate is due to a combination of KPC-2 production and decreased porin expression.
Prevalence of plasmid-mediated AmpC beta-lactamases in a Chinese university hospital from 2003 to 2005: first report of CMY-2-Type AmpC beta-lactamase resistance in China.
The study identified the presence of plasmid-mediated AmpC beta-lactamases, specifically blaDHA-1 and blaCMY-2, in clinical isolates of Escherichia coli and Klebsiella spp. in a Chinese university hospital. This is the first report of CMY-2-type AmpC beta-lactamase resistance in China.
Transferable, multiple antibiotic and mercury resistance in Atlantic Canadian isolates of Aeromonas salmonicida subsp. salmonicida is associated with carriage of an IncA/C plasmid similar to the Salmonella enterica plasmid pSN254.
The study identifies multiple antibiotic and mercury resistance genes carried by an IncA/C plasmid in Atlantic Canadian isolates of Aeromonas salmonicida subsp. salmonicida, including aadA7, floR, tetA, sulII, strA, strB, blaCMY-2, and a mercury resistance operon.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
The study identified various beta-lactamases, including CTX-M-3, CTX-M-15, SHV-2, SHV-5, SHV-12, TEM-19, TEM-48, CMY-12, CMY-15, CMY-38, TEM-30, TEM-32, TEM-37, and SHV-49, which confer resistance to newer beta-lactam antibiotics in Enterobacteriaceae isolates from Polish hospitals.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
The study identified various beta-lactamases, including CTX-M-3, CTX-M-15, SHV-2, SHV-5, SHV-12, TEM-19, TEM-48, CMY-12, CMY-15, CMY-38, TEM-30, TEM-32, TEM-37, and SHV-49, which confer resistance to newer beta-lactam antibiotics in Enterobacteriaceae isolates from Polish hospitals.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
The study identified various beta-lactamases, including CTX-M-3, CTX-M-15, SHV-2, SHV-5, SHV-12, TEM-19, TEM-48, CMY-12, CMY-15, CMY-38, TEM-30, TEM-32, TEM-37, and SHV-49, which confer resistance to newer beta-lactam antibiotics in Enterobacteriaceae isolates from Polish hospitals.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
Ceftriaxone-resistant salmonella enterica serotype Newport, France.
The study identifies the blaCMY-2 gene as the primary cause of ceftriaxone and ceftazidime resistance in Salmonella enterica serotype Newport isolates in France from 2000 to 2005.
Genetic characterization of clinical and agri-food isolates of multi drug resistant Salmonella enterica serovar Heidelberg from Canada.
The study identified the bla_cmy-2 gene as a major contributor to extended-spectrum cephalosporin resistance in Salmonella enterica serovar Heidelberg isolates, with the gene also found in E. coli isolates. The gene was located on high-molecular-weight plasmids and contributed to multidrug resistance.
Emergence of a cefepime- and cefpirome-resistant Citrobacter freundii clinical isolate harbouring a novel chromosomally encoded AmpC beta-lactamase, CMY-37.
Emergence of a cefepime- and cefpirome-resistant Citrobacter freundii clinical isolate harbouring a novel chromosomally encoded AmpC beta-lactamase, CMY-37.
Emergence of a cefepime- and cefpirome-resistant Citrobacter freundii clinical isolate harbouring a novel chromosomally encoded AmpC beta-lactamase, CMY-37.
Emergence of a cefepime- and cefpirome-resistant Citrobacter freundii clinical isolate harbouring a novel chromosomally encoded AmpC beta-lactamase, CMY-37.
Antimicrobial resistance in Salmonella enterica serovar Heidelberg isolates from retail meats, including poultry, from 2002 to 2006.
The study identified blaCMY as a gene responsible for ceftiofur resistance in Salmonella enterica serovar Heidelberg isolates from retail meats, with additional resistance to other beta-lactam antibiotics.
Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experience.
The study identifies multiple beta-lactamase genes, including bla CMY-2, bla DHA, bla TEM, bla CTX-M, bla IMP-4, and bla KPC-2, contributing to broad-spectrum beta-lactam resistance in Enterobacteriaceae isolates from a children's hospital.
Effects of Therapeutic Ceftiofur Administration to Dairy Cattle on Escherichia coli Dynamics in the Intestinal Tract.
The study identified the bla CMY-2 gene as a determinant of ceftiofur and ceftriaxone resistance in Escherichia coli isolated from dairy cattle following therapeutic ceftiofur administration.
Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-2, bla CTX-M-5, bla CTX-M-15, bla CTX-M-22, bla CTX-M-28, bla SHV-5, bla SHV-12, bla TEM-1, bla OXA-1, bla OXA-2, bla OXA-5, bla PER-1, bla ACT-1, bla MIR-1, bla CMY-2, bla FOX-1, bla DHA-1, and bla KPC-2, in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates.
CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids.
CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids.
CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids.
CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids.
CTX-M-14 and CTX-M-15 enzymes are the dominant type of extended-spectrum beta-lactamase in clinical isolates of Escherichia coli from Korea.
The study identifies CTX-M-14 and CTX-M-15 as the dominant extended-spectrum beta-lactamases in clinical isolates of Escherichia coli in Korea, along with other CTX-M variants and plasmid-borne AmpC beta-lactamases such as DHA-1, CMY-2, CMY-10, and CMY-11.
Prevalence and molecular characterization of ampicillin-resistant Enterobacteriaceae isolated from traditional Egyptian Domiati cheese.
Prevalence and molecular characterization of ampicillin-resistant Enterobacteriaceae isolated from traditional Egyptian Domiati cheese.
Prevalence and molecular characterization of ampicillin-resistant Enterobacteriaceae isolated from traditional Egyptian Domiati cheese.
Prevalence and molecular characterization of ampicillin-resistant Enterobacteriaceae isolated from traditional Egyptian Domiati cheese.
Role of ceftiofur in selection and dissemination of blaCMY-2-mediated cephalosporin resistance in Salmonella enterica and commensal Escherichia coli isolates from cattle.
The study investigated the role of ceftiofur in the selection and dissemination of blaCMY-2-mediated cephalosporin resistance in Salmonella enterica and commensal Escherichia coli isolates from cattle. The blaCMY-2 gene was found to confer resistance to cephalosporins.
CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases.
CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases.
CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases.
CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases.
CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases.
CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases.
CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases.
CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases.
Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase.
Three Escherichia coli clinical isolates with reduced susceptibility to cefepime were found to produce novel variants of CMY-2 beta-lactamase, CMY-33 and CMY-44, which have deletions in the H-10 helix leading to increased MICs of cefepime.
Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase.
Three Escherichia coli clinical isolates with reduced susceptibility to cefepime were found to produce novel variants of CMY-2 beta-lactamase, CMY-33 and CMY-44, which have deletions in the H-10 helix leading to increased MICs of cefepime.
Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase.
Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase.
Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase.
Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase.
Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase.
Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase.
Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase.
Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase.
Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase.
The Val211Gly mutation in CMY-2 enhances its ability to hydrolyze extended-spectrum cephalosporins and aztreonam, leading to increased resistance.
Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase.
The Val211Gly mutation in CMY-2 enhances its ability to hydrolyze extended-spectrum cephalosporins and aztreonam, leading to increased resistance.
Antimicrobial resistance genes in Escherichia coli isolates recovered from a commercial beef processing plant
The study identified various antimicrobial resistance genes in E. coli isolates from a commercial beef processing plant, including beta-lactamase genes (blaCMY, blaSHV, blaTEM), tetracycline resistance genes (tetA, tetB, tetC), sulfonamide resistance genes (sul1, sul2), and aminoglycoside resistance genes (strA, strB).
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
The study identified several acquired AmpC beta-lactamases, including CMY-2, CMY-25, CMY-27, CMY-40, DHA-1, and ACC-1, in Enterobacteriaceae strains from a Spanish hospital between 1999 and 2007. These enzymes conferred resistance to various beta-lactam antibiotics and other drugs.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
The study identified several acquired AmpC beta-lactamases, including CMY-2, CMY-25, CMY-27, CMY-40, DHA-1, and ACC-1, in Enterobacteriaceae strains from a Spanish hospital between 1999 and 2007. These enzymes conferred resistance to various beta-lactam antibiotics and other drugs.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
The study identified several acquired AmpC beta-lactamases, including CMY-2, CMY-25, CMY-27, CMY-40, DHA-1, and ACC-1, in Enterobacteriaceae strains from a Spanish hospital between 1999 and 2007. These enzymes conferred resistance to various beta-lactam antibiotics and other drugs.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
The study identified several acquired AmpC beta-lactamases, including CMY-2, CMY-25, CMY-27, CMY-40, DHA-1, and ACC-1, in Enterobacteriaceae strains from a Spanish hospital between 1999 and 2007. These enzymes conferred resistance to various beta-lactam antibiotics and other drugs.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
Association of virulence plasmid and antibiotic resistance determinants with chromosomal multilocus genotypes in Mexican Salmonella enterica serovar Typhimurium strains.
The study identifies cmy-2, pSTV, IP-1, and SGI1 as key antibiotic resistance determinants in Mexican Salmonella Typhimurium strains, showing their association with specific chromosomal genotypes and resistance phenotypes.
Molecular epidemiology of CTX-M-producing Escherichia coli isolates at a tertiary medical center in western Pennsylvania.
Molecular epidemiology of CTX-M-producing Escherichia coli isolates at a tertiary medical center in western Pennsylvania.
Molecular epidemiology of CTX-M-producing Escherichia coli isolates at a tertiary medical center in western Pennsylvania.
Role of lysine-67 in the active site of class C beta-lactamase from Citrobacter freundii GN346.
Role of lysine-67 in the active site of class C beta-lactamase from Citrobacter freundii GN346.
beta-Lactam resistance in salmonella strains isolated from retail meats in the United States by the National Antimicrobial Resistance Monitoring System between 2002 and 2006.
The study identified bla CMY and bla TEM-1 as the primary beta-lactam resistance genes in Salmonella isolates from retail meats, contributing to resistance against multiple beta-lactam antibiotics.
Multilocus variable-number tandem-repeat analysis and plasmid profiling to study the occurrence of blaCMY-2 within a pulsed-field gel electrophoresis-defined clade of Salmonella enterica serovar Typhimurium.
The study identifies blaCMY-2 as a gene responsible for ceftazidime resistance in Salmonella enterica serovar Typhimurium within a specific clade.
Enhancing resistance to cephalosporins in class C beta-lactamases: impact of Gly214Glu in CMY-2.
The study characterizes the CMY-2 and CMY-32 beta-lactamases, highlighting the impact of the Gly214Glu substitution in CMY-32 on resistance to various beta-lactam antibiotics, particularly cefotaxime and aztreonam.
Enhancing resistance to cephalosporins in class C beta-lactamases: impact of Gly214Glu in CMY-2.
The study characterizes the CMY-2 and CMY-32 beta-lactamases, highlighting the impact of the Gly214Glu substitution in CMY-32 on resistance to various beta-lactam antibiotics, particularly cefotaxime and aztreonam.
Enhancing resistance to cephalosporins in class C beta-lactamases: impact of Gly214Glu in CMY-2.
blaCMY-2-positive IncA/C plasmids from Escherichia coli and Salmonella enterica are a distinct component of a larger lineage of plasmids.
The study identifies blaCMY-2 as a gene encoding a beta-lactamase that confers resistance to third-generation cephalosporins in Escherichia coli and Salmonella enterica serovar Newport.
Updated functional classification of beta-lactamases.
The paper updates the functional classification of beta-lactamases, detailing their substrate preferences, inhibitor profiles, and clinical relevance. It highlights the diversity and evolution of these enzymes, emphasizing their role in antibiotic resistance.
Molecular characterization of extended-spectrum cephalosporinase-producing Salmonella enterica serovar Choleraesuis isolates from patients in Thailand and Denmark.
The study identified bla CTX-M-14 and bla CMY-2 as the primary genes responsible for extended-spectrum cephalosporin resistance in Salmonella enterica serovar Choleraesuis isolates from Thailand and Denmark.
Occurrence of antimicrobial resistant bacteria in healthy dogs and cats presented to private veterinary hospitals in southern Ontario: A preliminary study.
The study identified the presence of CMY-2-producing E. coli in two dogs, indicating resistance to cephamycins and beta-lactam/beta-lactamase inhibitor combinations.
Coexistence of multiple antimicrobial-resistance genes in a carbapenem-resistant Citrobacter freundii clinical isolate from China.
Coexistence of multiple antimicrobial-resistance genes in a carbapenem-resistant Citrobacter freundii clinical isolate from China.
Coexistence of multiple antimicrobial-resistance genes in a carbapenem-resistant Citrobacter freundii clinical isolate from China.
Coexistence of multiple antimicrobial-resistance genes in a carbapenem-resistant Citrobacter freundii clinical isolate from China.
Epidemiology of Escherichia coli clinical isolates producing AmpC plasmidic beta-lactamase during a 5-year period in a French teaching Hospital.
Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate.
The study identifies a novel SXT/R391-related integrating conjugative element, ICE Pmi Jpn1, carrying the chromosomally encoded blaCMY-2 gene in a Proteus mirabilis clinical isolate, which confers resistance to extended-spectrum cephalosporins.
Laboratory surveillance for prospective plasmid-mediated AmpC beta-lactamases in the Kinki region of Japan.
The study identified plasmid-mediated AmpC beta-lactamases (PABLs) in various Enterobacteriaceae isolates, with CMY-2 being the most prevalent in E. coli, DHA-1 in K. pneumoniae, and MOX-1 in K. oxytoca.
Laboratory surveillance for prospective plasmid-mediated AmpC beta-lactamases in the Kinki region of Japan.
The study identified plasmid-mediated AmpC beta-lactamases (PABLs) in various Enterobacteriaceae isolates, with CMY-2 being the most prevalent in E. coli, DHA-1 in K. pneumoniae, and MOX-1 in K. oxytoca.
Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC beta-lactamases.
The study characterizes the carbapenem-hydrolyzing activities of five plasmid-borne AmpC beta-lactamases (CMY-2, ACT-1, DHA-1, FOX-1, and ACC-1) and shows that CMY-2, ACT-1, and DHA-1 confer resistance to imipenem, while FOX-1 and ACC-1 do not.
Escherichia coli and selected veterinary and zoonotic pathogens isolated from environmental sites in companion animal veterinary hospitals in southern Ontario.
The study identified bla CMY-2 encoding extended-spectrum beta-lactamase-producing E. coli in environmental samples from veterinary hospitals, highlighting the presence of antimicrobial resistance genes in healthcare settings.
The Salmonella genomic island 1 is specifically mobilized in trans by the IncA/C multidrug resistance plasmid family.
The study shows that the IncA/C multidrug resistance plasmid family specifically mobilizes the Salmonella genomic island 1 (SGI1) in trans, facilitating its horizontal transfer among enteric pathogens.
Salmonella Typhimurium ST213 is associated with two types of IncA/C plasmids carrying multiple resistance determinants.
The study identifies bla CMY-2, dfrA12, orfF, aadA2, floR, and mer as resistance genes carried by IncA/C plasmids in Salmonella Typhimurium ST213, contributing to multidrug resistance.
Chromosome-encoded AmpC and CTX-M extended-spectrum beta-lactamases in clinical isolates of Proteus mirabilis from Korea.
The study identifies several extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase genes, including bla CTX-M-14a, bla CTX-M-90, bla CTX-M-15, bla CTX-M-12, bla CTX-M-2, bla CTX-M-14b, bla TEM-52, bla SHV-12, bla CMY-2, and bla DHA-1, in clinical isolates of Proteus mirabilis from Korea. These genes were found to be responsible for resistance to various β-lactam antibiotics.
CMY-42, a novel plasmid-mediated CMY-2 variant AmpC beta-lactamase.
CMY-42, a novel plasmid-mediated CMY-2 variant AmpC beta-lactamase.
CMY-42, a novel plasmid-mediated CMY-2 variant AmpC beta-lactamase.
CMY-42, a novel plasmid-mediated CMY-2 variant AmpC beta-lactamase.
Evolution and spread of a multidrug-resistant Proteus mirabilis clone with chromosomal AmpC-type cephalosporinases in Europe.
The study identifies multiple blaCMY alleles, including a new allele blaCMY-45, in multidrug-resistant Proteus mirabilis clones across Europe, highlighting the evolution and spread of chromosomal AmpC-type cephalosporinases.
Evolution and spread of a multidrug-resistant Proteus mirabilis clone with chromosomal AmpC-type cephalosporinases in Europe.
The study identifies multiple blaCMY alleles, including a new allele blaCMY-45, in multidrug-resistant Proteus mirabilis clones across Europe, highlighting the evolution and spread of chromosomal AmpC-type cephalosporinases.
Evolution and spread of a multidrug-resistant Proteus mirabilis clone with chromosomal AmpC-type cephalosporinases in Europe.
The study identifies multiple blaCMY alleles, including a new allele blaCMY-45, in multidrug-resistant Proteus mirabilis clones across Europe, highlighting the evolution and spread of chromosomal AmpC-type cephalosporinases.
Evolution and spread of a multidrug-resistant Proteus mirabilis clone with chromosomal AmpC-type cephalosporinases in Europe.
The study identifies multiple blaCMY alleles, including a new allele blaCMY-45, in multidrug-resistant Proteus mirabilis clones across Europe, highlighting the evolution and spread of chromosomal AmpC-type cephalosporinases.
Evolution and spread of a multidrug-resistant Proteus mirabilis clone with chromosomal AmpC-type cephalosporinases in Europe.
The study identifies multiple blaCMY alleles, including a new allele blaCMY-45, in multidrug-resistant Proteus mirabilis clones across Europe, highlighting the evolution and spread of chromosomal AmpC-type cephalosporinases.
Evolution and spread of a multidrug-resistant Proteus mirabilis clone with chromosomal AmpC-type cephalosporinases in Europe.
The study identifies multiple blaCMY alleles, including a new allele blaCMY-45, in multidrug-resistant Proteus mirabilis clones across Europe, highlighting the evolution and spread of chromosomal AmpC-type cephalosporinases.
Evolution and spread of a multidrug-resistant Proteus mirabilis clone with chromosomal AmpC-type cephalosporinases in Europe.
The study identifies multiple blaCMY alleles, including a new allele blaCMY-45, in multidrug-resistant Proteus mirabilis clones across Europe, highlighting the evolution and spread of chromosomal AmpC-type cephalosporinases.
Evolution and spread of a multidrug-resistant Proteus mirabilis clone with chromosomal AmpC-type cephalosporinases in Europe.
Evolution and spread of a multidrug-resistant Proteus mirabilis clone with chromosomal AmpC-type cephalosporinases in Europe.
Evolution and spread of a multidrug-resistant Proteus mirabilis clone with chromosomal AmpC-type cephalosporinases in Europe.
Evolution and spread of a multidrug-resistant Proteus mirabilis clone with chromosomal AmpC-type cephalosporinases in Europe.
Emergence of NDM-1-producing Enterobacteriaceae in Belgium.
The study reports the emergence of NDM-1-producing Enterobacteriaceae in Belgium, highlighting the presence of multiple resistance mechanisms including blaNDM-1, qnrA6, qnrB1, qnrB2, and various beta-lactamases, rRNA methylases, and quinolone resistance genes.
Emergence of NDM-1-producing Enterobacteriaceae in Belgium.
The study reports the emergence of NDM-1-producing Enterobacteriaceae in Belgium, highlighting the presence of multiple resistance mechanisms including blaNDM-1, qnrA6, qnrB1, qnrB2, and various beta-lactamases, rRNA methylases, and quinolone resistance genes.
Emergence of NDM-1-producing Enterobacteriaceae in Belgium.
Emergence of NDM-1-producing Enterobacteriaceae in Belgium.
Emergence of NDM-1-producing Enterobacteriaceae in Belgium.
Emergence of NDM-1-producing Enterobacteriaceae in Belgium.
Selection pressure required for long-term persistence of blaCMY-2-positive IncA/C plasmids.
The study identifies blaCMY-2 as a gene that confers resistance to expanded-spectrum cephalosporins and examines its persistence in bacterial populations under different selection pressures.
Characterization of Salmonella enterica serovar Typhimurium isolates harboring a chromosomally encoded CMY-2 beta-lactamase gene located on a multidrug resistance genomic island.
The study characterizes a chromosomally encoded CMY-2 beta-lactamase gene located on a multidrug resistance genomic island in Salmonella enterica serovar Typhimurium isolates, highlighting its role in resistance to multiple beta-lactam antibiotics.
Increasing ceftriaxone resistance in Salmonellae, Taiwan.
The study identifies a self-transferable blaCMY-2-harboring IncI1 plasmid contributing to increased ceftriaxone resistance in Salmonella isolates in Taiwan.
Increasing secondary bacterial infections with Enterobacteriaceae harboring bla(CTX-M-15) and bla(CMY-6) in patients with bronchogenic carcinoma: an emerging point of concern.
The study identifies bla(CTX-M-15) and bla(CMY-6) as prevalent resistance genes in Enterobacteriaceae isolated from bronchogenic carcinoma patients, contributing to multidrug resistance.
Faecal shedding of CTX-M-producing Escherichia coli in horses receiving broad-spectrum antimicrobial prophylaxis after hospital admission.
Faecal shedding of CTX-M-producing Escherichia coli in horses receiving broad-spectrum antimicrobial prophylaxis after hospital admission.
Faecal shedding of CTX-M-producing Escherichia coli in horses receiving broad-spectrum antimicrobial prophylaxis after hospital admission.
Faecal shedding of CTX-M-producing Escherichia coli in horses receiving broad-spectrum antimicrobial prophylaxis after hospital admission.
Faecal shedding of CTX-M-producing Escherichia coli in horses receiving broad-spectrum antimicrobial prophylaxis after hospital admission.
Faecal shedding of CTX-M-producing Escherichia coli in horses receiving broad-spectrum antimicrobial prophylaxis after hospital admission.
Faecal shedding of CTX-M-producing Escherichia coli in horses receiving broad-spectrum antimicrobial prophylaxis after hospital admission.
Characterization of multidrug-resistant Escherichia coli isolates from animals presenting at a university veterinary hospital.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from animals, including bla TEM, bla CTX-M-2, bla CMY-2, strA-strB, aadA, aphA1, aadB, cat, floR, sul1, sul2, tet(A), and tet(B). These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, chloramphenicol, sulfonamides, and tetracyclines.
Transmission of imipenem resistance determinants during the course of an outbreak of NDM-1 Escherichia coli in a sick newborn care unit.
Detection of clinically important beta-lactamases in commensal Escherichia coli of human and swine origin in western China.
The study identified various beta-lactamase genes, including bla CTX-M-1 group variants and bla SHV, as prevalent in commensal E. coli from humans and swine in western China. Additionally, bla CMY-2 was commonly found in both human and swine isolates, while bla KPC was detected in some human isolates.
Phylogenetic groups and cephalosporin resistance genes of Escherichia coli from diseased food-producing animals in Japan.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-2, bla CTX-M-25, bla CTX-M-15, and bla SHV-2, as well as the AmpC beta-lactamase gene bla CMY-2, in Escherichia coli isolates from diseased food-producing animals in Japan.
Molecular diversity in mechanisms of carbapenem resistance in paediatric Enterobacteriaceae.
The study identifies various carbapenem resistance mechanisms in pediatric Enterobacteriaceae, including plasmid-mediated beta-lactamases (CTX-M, CMY, KPC, IMP), chromosomal beta-lactamase (SME), and porin alterations (ompK35 and ompK36).
Evolution of an incompatibility group IncA/C plasmid harboring blaCMY-16 and qnrA6 genes and its transfer through three clones of Providencia stuartii during a two-year outbreak in a Tunisian burn unit.
The study identifies blaCMY-16 and qnrA6 as the primary resistance genes in a multidrug-resistant outbreak of Providencia stuartii, highlighting the role of IncA/C plasmids in the dissemination of these genes.
Characterization of isolates of Salmonella enterica serovar Stanley, a serovar endemic to Asia and associated with travel.
The study identified the bla CMY-2 gene as a major contributor to extended-spectrum cephalosporin resistance in Salmonella enterica serovar Stanley isolates, along with the qnrS1 gene associated with plasmid-mediated quinolone resistance.
Hydrolysis Spectrum Extension of CMY-2-Like beta-lactamases Resulting from Structural Alteration in the Y-X-N Loop.
The study identifies a novel ESAC beta-lactamase, AmpC-CHA, and characterizes the R148H mutation in CMY-2 and AmpC-CHA, which extends the hydrolysis spectrum to include cefepime, ceftazidime, and cefotaxime.
Comparison of the prevalences and antimicrobial resistances of Escherichia coli isolates from different retail meats in the United States, 2002 to 2008.
The study identified several AMR genes and mutations in E. coli isolates from retail meats, including bla CMY, cmlA, flo, catI, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Clinical and Microbiologic Characteristics of Cephalosporin-Resistant Escherichia coli at Three Centers in the United States.
The study identified CTX-M-15 as the most common ESBL in cephalosporin-resistant E. coli, followed by CMY-2, SHV, TEM, and KPC beta-lactamases. These genes confer resistance to various beta-lactam antibiotics.
Transcriptome mapping of pAR060302, a blaCMY-2-positive broad-host-range IncA/C plasmid.
The study characterizes the transcriptome of pAR060302, a blaCMY-2-positive IncA/C plasmid, highlighting the transcription of resistance genes such as blaCMY-2, aadA, aacA, and floR, which confer resistance to extended-spectrum cephalosporins, aminoglycosides, and phenicols, respectively.
Characterization of extended-spectrum beta-lactamase genes found among Escherichia coli isolates from duck and environmental samples obtained on a duck farm.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-105, bla CTX-M-27, bla CTX-M-55, bla CTX-M-24e, and others, in Escherichia coli isolates from ducks and environmental samples. These genes confer resistance to various β-lactam antibiotics and other antimicrobials.
Current epidemiology and growing resistance of gram-negative pathogens.
The paper highlights the emergence and spread of multidrug-resistant Gram-negative pathogens, focusing on extended-spectrum beta-lactamases (ESBLs) such as CTX-M-15 and CTX-M-14, carbapenemases like KPC-2, VIM-2, and IMP-6, and aminoglycoside-modifying enzymes such as aac(6')-Ib-cr and armA. It emphasizes the global dissemination of these resistance mechanisms and their impact on treatment options.
Characterization of extended-spectrum cephalosporin-resistant Salmonella enterica serovar Heidelberg isolated from food animals, retail meat, and humans in the United States 2009.
The study identified blaCMY genes on IncI1 and IncA/C plasmids as the primary cause of extended-spectrum cephalosporin resistance in Salmonella enterica serovar Heidelberg isolates from food animals, retail meat, and humans in the United States in 2009.
Increased frequency of integrons and beta-lactamase-coding genes among extraintestinal Escherichia coli isolated with a 7-year interval.
The study identified an increase in the frequency of integrons and beta-lactamase-coding genes, particularly bla CTX-M-1, bla CTX-M-3, bla CTX-M-15, bla CTX-M-55, bla TEM-1, bla OXA-1, bla SHV-1, bla SHV-12, bla CMY-15, and bla DHA, in extraintestinal Escherichia coli strains isolated over a 7-year period.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
AmpC beta-lactamases in nosocomial isolates of Klebsiella pneumoniae from India.
The study identified 12 CMY-2 and 8 DHA-1 types of plasmid-mediated AmpC beta-lactamases in Klebsiella pneumoniae isolates from India, highlighting their prevalence and significance in antibiotic resistance.
CTX-M-producing Escherichia coli and Klebsiella pneumoniae isolated from community-acquired urinary tract infections in Valledupar, Colombia.
The study identified CTX-M-1, TEM, SHV, and CMY-2 beta-lactamase genes in E. coli and K. pneumoniae isolates from community-acquired UTIs in Colombia, highlighting the presence of multidrug-resistant strains.
Urine from treated cattle drives selection for cephalosporin resistant Escherichia coli in soil.
The study identifies bla CMY-2 as a gene conferring resistance to cephalosporins in Escherichia coli, highlighting its role in selecting for resistant strains in soil environments.
A binational cohort study of intestinal colonization with extended-spectrum β-lactamase-producing Proteus mirabilis in patients admitted to rehabilitation centres.
The study identified TEM-92, CTX-M-2, and TEM-177 as the primary extended-spectrum β-lactamase (ESBL) genes in Proteus mirabilis isolates from rehabilitation centers in Italy and Israel.
A binational cohort study of intestinal colonization with extended-spectrum β-lactamase-producing Proteus mirabilis in patients admitted to rehabilitation centres.
The study identified TEM-92, CTX-M-2, and TEM-177 as the primary extended-spectrum β-lactamase (ESBL) genes in Proteus mirabilis isolates from rehabilitation centers in Italy and Israel.
Study on drug resistance of Pseudomonas aeruginosa plasmid-mediated AmpC beta-lactamase.
The study identified a plasmid-mediated CMY-7 type AmpC beta-lactamase in Pseudomonas aeruginosa, which confers resistance to cefoxitin.
DNA sequence analysis of plasmids from multidrug resistant Salmonella enterica serotype Heidelberg isolates.
The study identified multiple antimicrobial resistance genes in plasmids from multidrug-resistant Salmonella enterica serotype Heidelberg isolates, including bla CMY, aadA, aadB, aphA, strA, strB, sul1, sul2, tetA, floR, cmlA, dfrA1, dfrA12, and aacC.
Population distribution of Beta-lactamase conferring resistance to third-generation cephalosporins in human clinical Enterobacteriaceae in the Netherlands.
The study identifies bla CTX-M-15 as the most prevalent ESBL gene in third-generation cephalosporin-resistant Enterobacteriaceae in the Netherlands, along with various other ESBL and AmpC genes such as bla CTX-M-1, bla CTX-M-14, bla SHV-12, bla TEM-52, and bla CMY-2. Mutations in the promoter region of the chromosomal ampC gene were also found to contribute to resistance.
Detection of clonally related Escherichia coli isolates producing different CMY β-lactamases from a cystic fibrosis patient.
Detection of clonally related Escherichia coli isolates producing different CMY β-lactamases from a cystic fibrosis patient.
Detection of clonally related Escherichia coli isolates producing different CMY β-lactamases from a cystic fibrosis patient.
Detection of clonally related Escherichia coli isolates producing different CMY β-lactamases from a cystic fibrosis patient.
Detection of clonally related Escherichia coli isolates producing different CMY β-lactamases from a cystic fibrosis patient.
Detection of clonally related Escherichia coli isolates producing different CMY β-lactamases from a cystic fibrosis patient.
Detection of clonally related Escherichia coli isolates producing different CMY β-lactamases from a cystic fibrosis patient.
Detection of clonally related Escherichia coli isolates producing different CMY β-lactamases from a cystic fibrosis patient.
Influence of Therapeutic Ceftiofur Treatments of Feedlot Cattle on Fecal and Hide Prevalences of Commensal Escherichia coli Resistant to Extended-Spectrum Cephalosporins, and Molecular Characterization of Resistant Isolates.
The study identified the blaCMY-2 gene as a major contributor to extended-spectrum cephalosporin resistance in Escherichia coli isolates from feedlot cattle, with clonal expansion playing a significant role in its persistence.
Emergence of extended-spectrum β-lactam resistance among Escherichia coli at a US academic children's hospital is clonal at the sequence type level for CTX-M-15, but not for CMY-2.
The study identifies bla CTX-M-15 and bla CMY-2 as the primary extended-spectrum β-lactam resistance genes in E. coli isolates from a US children's hospital, with CTX-M-15 showing clonal spread while CMY-2 exhibits non-clonal distribution.
Antimicrobial resistance, virulence factors and genetic diversity of Escherichia coli isolates from household water supply in Dhaka, Bangladesh.
The study identified several AMR genes in E. coli isolates from household water in Dhaka, including bla CTX-M-15, bla CTX-M-1-group, bla TEM, bla OXA-1-group, bla OXA-47, qnrS, qnrB, and bla CMY-2. These genes conferred resistance to multiple antibiotics, highlighting the presence of multidrug-resistant E. coli in the water supply.
Antibiotic administration routes significantly influence the levels of antibiotic resistance in gut microbiota.
The study shows that oral administration of antibiotics leads to higher levels of antibiotic resistance gene pools in the gut microbiota compared to intravenous administration. Specifically, the tet(M) gene and blaCMY-2 gene were found to confer resistance to tetracycline and ampicillin, respectively.
Cross-sectional study on prevalence and molecular characteristics of plasmid mediated ESBL/AmpC-producing Escherichia coli isolated from veal calves at slaughter.
The study identified bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and other bla CTX-M variants as the major genes responsible for plasmid-mediated resistance to cefotaxime in E. coli from veal calves. Additionally, aac(6')-Ib-cr was found to confer resistance to aminoglycosides and fluoroquinolones.
Chronological Change of Resistance to β-Lactams in Salmonella enterica serovar Infantis Isolated from Broilers in Japan.
The study identified the emergence of Salmonella enterica serovar Infantis isolates carrying blaTEM-52, blaTEM-20, blaCTX-M-25, and blaCMY-2 genes, which confer resistance to extended-spectrum cephalosporins and other beta-lactams. Additionally, non-beta-lactam resistance genes such as aadA1, sul1, tet(A), and aphA1-Iab were prevalent.
Genetic mechanisms of antimicrobial resistance identified in Salmonella enterica, Escherichia coli, and Enteroccocus spp. isolated from U.S. food animals.
The study identifies various AMR genes in Salmonella enterica, Escherichia coli, and Enterococcus spp. isolated from U.S. food animals, including aac(3'), aac(6'), aadA, aadA1, aadA2, aadA12, aphAI, aph(3')-Ii-iv, strA, strB, bla CMY-2, bla TEM-1, bla PSE-1, floR, cmlA, cat1, cat2, sul1, sul2, dfr1, dfrA10, tet(A), tet(B), tet(C), tet(D), tet(G), and tetR.
The occurrence of extended-spectrum beta-lactamase producing Shigella spp. in Tehran, Iran.
The study identified ESBL-producing Shigella isolates, including S. sonnei and S. flexneri, carrying bla TEM-1, bla CTX-M-15, and bla CMY-59 genes, highlighting the emergence of multidrug-resistant strains in Tehran, Iran.
The occurrence of extended-spectrum β-lactamase producing Shigella spp. in Tehran, Iran.
An Increase in the clinical isolation of acquired AmpC beta-lactamase-producing Klebsiella pneumoniae in Korea from 2007 to 2010.
The study identified an increase in the clinical isolation of acquired AmpC beta-lactamase-producing Klebsiella pneumoniae in Korea from 2007 to 2010, with blaDHA-1 and blaCMY-2 being the predominant AmpC enzymes. These genes conferred resistance to several β-lactam antibiotics.
Characteristics of cefotaxime-resistant Escherichia coli from wild birds in the Netherlands.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-3, bla CTX-M-14, bla CTX-M-32, and bla CMY-2, as well as plasmid-mediated quinolone resistance (PMQR) genes such as aac(6')-lb-cr, qnrB1, and qnrS1, in cefotaxime-resistant Escherichia coli isolates from wild birds in the Netherlands.
Long-term dissemination of acquired AmpC beta-lactamases among Klebsiella spp. and Escherichia coli in Portuguese clinical settings.
The study identifies the long-term dissemination of acquired AmpC beta-lactamases, particularly DHA-1 and CMY-2, among Klebsiella spp. and Escherichia coli in Portuguese clinical settings.
Incidence, clinical presentation, and antimicrobial resistance trends in Salmonella and Shigella infections from children in Yucatan, Mexico.
The study identified bla CMY-2 as a common gene conferring ceftriaxone resistance in Salmonella isolates and qnrA1 and qnrB19 as genes contributing to ciprofloxacin resistance.
No evidence so far for the dissemination of carbapenemase-producing Enterobactericeae in the community in Switzerland.
The study found no carbapenemase genes in the analyzed isolates, but detected extended-spectrum beta-lactamase CTX-M-15 in 4 isolates, CTX-M-14 in one isolate, and plasmidic AmpC-beta-lactamase CMY-2 in another isolate.
Detection of CMY-99, a novel acquired AmpC-Type beta-lactamase, and VIM-1 in Proteus mirabilis isolates in Bulgaria.
The study reports the identification of CMY-99, a novel AmpC-type beta-lactamase, and VIM-1, a metallo-beta-lactamase, in Proteus mirabilis isolates from Bulgaria, highlighting the emergence of multidrug-resistant strains.
Detection of CMY-99, a novel acquired AmpC-Type β-lactamase, and VIM-1 in Proteus mirabilis isolates in Bulgaria.
Detection of CMY-99, a novel acquired AmpC-Type β-lactamase, and VIM-1 in Proteus mirabilis isolates in Bulgaria.
Detection of CMY-99, a novel acquired AmpC-Type β-lactamase, and VIM-1 in Proteus mirabilis isolates in Bulgaria.
Detection of CMY-99, a novel acquired AmpC-Type β-lactamase, and VIM-1 in Proteus mirabilis isolates in Bulgaria.
Characteristics of clinical Shiga toxin-producing Escherichia coli isolated from British Columbia.
The study identified a clinical STEC isolate (BC-20) carrying the bla CMY-2 gene, which confers resistance to several beta-lactam antibiotics, including cefoxitin, ceftriaxone, and ceftiofur. The gene was confirmed by PCR and DNA sequencing, and the resistance was shown to be transferable via conjugation.
Presence of ESBL/AmpC-producing Escherichia coli in the broiler production pyramid: a descriptive study.
The study identified several ESBL/AmpC genes including bla CMY-2, bla TEM-52, bla TEM-52c, bla CTX-M-1, and bla CTX-M-2 in ESBL/AmpC-producing E. coli isolates from various levels of the broiler production pyramid.
Effects of ceftiofur and chlortetracycline treatment strategies on antimicrobial susceptibility and on tet(A), tet(B), and bla CMY-2 resistance genes among E. coli isolated from the feces of feedlot cattle.
The study identified tet(A), tet(B), and bla CMY-2 as key resistance genes in E. coli isolates from feedlot cattle, with bla CMY-2 associated with high multidrug resistance. CTC treatment influenced the selection of tetracycline resistance genes, favoring tet(B) over tet(A).
Conjugative transfer of an IncA/C plasmid-borne blaCMY-2 gene through genetic re-arrangements with an IncX1 plasmid.
The study identified the blaCMY-2 gene, which confers resistance to ceftriaxone, and demonstrated its transfer through genetic rearrangements between IncA/C and IncX1 plasmids.
GES-5 among the β-lactamases detected in ubiquitous bacteria isolated from aquatic environment samples.
GES-5 among the β-lactamases detected in ubiquitous bacteria isolated from aquatic environment samples.
GES-5 among the β-lactamases detected in ubiquitous bacteria isolated from aquatic environment samples.
GES-5 among the β-lactamases detected in ubiquitous bacteria isolated from aquatic environment samples.
GES-5 among the β-lactamases detected in ubiquitous bacteria isolated from aquatic environment samples.
GES-5 among the β-lactamases detected in ubiquitous bacteria isolated from aquatic environment samples.
GES-5 among the β-lactamases detected in ubiquitous bacteria isolated from aquatic environment samples.
GES-5 among the β-lactamases detected in ubiquitous bacteria isolated from aquatic environment samples.
Frequency of plasmid-mediated AmpC in Enterobacteriaceae isolated in a Brazilian Teaching Hospital.
The study identified the presence of the blaCMY-2 gene in a single Klebsiella pneumoniae isolate, indicating plasmid-mediated AmpC beta-lactamase production.
Comparison of ESBL--and AmpC producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureus (MRSA) isolated from migratory and resident population of rooks (Corvus frugilegus) in Austria.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-3, bla CTX-M-15, bla TEM-1, bla TEM-15, bla OXA-1, and bla CMY-2, in Enterobacteriaceae isolates from rooks. These genes conferred resistance to cephalosporins such as cefotaxime and ceftazidime.
Multidrug-resistant Escherichia coli from canine urinary tract infections tend to have commensal phylotypes, lower prevalence of virulence determinants and ampC-replicons.
The study identified blaCMY-2 as a significant contributor to multidrug resistance in E. coli isolates from canine urinary tract infections, highlighting the role of plasmid-mediated AmpC β-lactamases in resistance mechanisms.
High diversity of plasmids harbouring blaCMY-2 among clinical Escherichia coli isolates from humans and companion animals in the upper Midwestern USA.
High diversity of plasmids harbouring blaCMY-2 among clinical Escherichia coli isolates from humans and companion animals in the upper Midwestern USA.
High diversity of plasmids harbouring blaCMY-2 among clinical Escherichia coli isolates from humans and companion animals in the upper Midwestern USA.
High diversity of plasmids harbouring blaCMY-2 among clinical Escherichia coli isolates from humans and companion animals in the upper Midwestern USA.
Genetic and phenotypic characterisation of Escherichia coli producing cefotaximase-type extended-spectrum β-lactamases: first evidence of the ST131 clone in cats with urinary infections in Italy.
The study identified CTX-M-1, CTX-M-14, and CTX-M-15 beta-lactamase genes in Escherichia coli isolates from cats with urinary tract infections, highlighting the presence of multidrug-resistant strains and the ST131 clone in Italy.
Detection and occurrence of plasmid-mediated AmpC in highly resistant gram-negative rods.
The study identified 13 pAmpC-producing Enterobacteriaceae isolates, including 9 CMY-2, 3 DHA-1, and 1 ACC-1 type in E. coli isolates. The prevalence of pAmpC was found to be 2.6% among group I Enterobacteriaceae.
Comparison of broad-spectrum cephalosporin-resistant Escherichia coli isolated from dogs and humans in Hokkaido, Japan.
Comparison of broad-spectrum cephalosporin-resistant Escherichia coli isolated from dogs and humans in Hokkaido, Japan.
Comparison of broad-spectrum cephalosporin-resistant Escherichia coli isolated from dogs and humans in Hokkaido, Japan.
Comparison of broad-spectrum cephalosporin-resistant Escherichia coli isolated from dogs and humans in Hokkaido, Japan.
Emergence of clinical Salmonella enterica serovar Typhimurium isolates with concurrent resistance to ciprofloxacin, ceftriaxone, and azithromycin.
The study identifies the emergence of highly drug-resistant (XDR) Salmonella enterica serovar Typhimurium isolates with resistance to ciprofloxacin, ceftriaxone, and azithromycin, driven by extended-spectrum beta-lactamases (ESBLs) and the oqxAB efflux pump.
Association of veterinary third-generation cephalosporin use with the risk of emergence of extended-spectrum-cephalosporin resistance in Escherichia coli from dairy cattle in Japan.
The study identified plasmid-mediated beta-lactamase genes bla CTX-M-2, bla CTX-M-14, and bla CMY-2 in Escherichia coli isolates from dairy cattle, which conferred resistance to various cephalosporins. These genes were located on self-transmissible plasmids and were associated with the emergence of extended-spectrum cephalosporin-resistant E. coli following veterinary use of ceftiofur.
Characterization of multi-antibiotic-resistant Escherichia coli Isolated from beef cattle in Japan.
The study identified multiple AMR genes in E. coli isolates from beef cattle in Japan, highlighting the diversity of resistance mechanisms and the potential for horizontal gene transfer.
IncA/C plasmid-mediated spread of CMY-2 in multidrug-resistant Escherichia coli from food animals in China.
The study identifies the spread of CMY-2, CMY-41, and CMY-64 beta-lactamase genes in multidrug-resistant E. coli from food animals in China, highlighting the role of IncA/C plasmids in their transfer and the coexistence of other resistance genes such as qnrS1, floR, aac-(6′)-Ib-cr, oqxA, and rmtB.
IncA/C plasmid-mediated spread of CMY-2 in multidrug-resistant Escherichia coli from food animals in China.
The study identifies the spread of CMY-2, CMY-41, and CMY-64 beta-lactamase genes in multidrug-resistant E. coli from food animals in China, highlighting the role of IncA/C plasmids in their transfer and the coexistence of other resistance genes such as qnrS1, floR, aac-(6′)-Ib-cr, oqxA, and rmtB.
IncA/C plasmid-mediated spread of CMY-2 in multidrug-resistant Escherichia coli from food animals in China.
The study identifies the spread of CMY-2, CMY-41, and CMY-64 beta-lactamase genes in multidrug-resistant E. coli from food animals in China, highlighting the role of IncA/C plasmids in their transfer and the coexistence of other resistance genes such as qnrS1, floR, aac-(6′)-Ib-cr, oqxA, and rmtB.
Reclaiming the efficacy of β-lactam-beta-lactamase inhibitor combinations: avibactam restores the susceptibility of CMY-2-producing Escherichia coli to ceftazidime.
Avibactam restores the susceptibility of CMY-2-producing Escherichia coli to ceftazidime by inactivating the CMY-2 beta-lactamase, demonstrating effective resistance reversal.
Reclaiming the efficacy of β-lactam-beta-lactamase inhibitor combinations: avibactam restores the susceptibility of CMY-2-producing Escherichia coli to ceftazidime.
Avibactam restores the susceptibility of CMY-2-producing Escherichia coli to ceftazidime by inactivating the CMY-2 beta-lactamase, demonstrating effective resistance reversal.
Reclaiming the efficacy of β-lactam-β-lactamase inhibitor combinations: avibactam restores the susceptibility of CMY-2-producing Escherichia coli to ceftazidime.
Reclaiming the efficacy of β-lactam-β-lactamase inhibitor combinations: avibactam restores the susceptibility of CMY-2-producing Escherichia coli to ceftazidime.
Reclaiming the efficacy of β-lactam-β-lactamase inhibitor combinations: avibactam restores the susceptibility of CMY-2-producing Escherichia coli to ceftazidime.
Plasmid-mediated AmpC beta-lactamase (CMY-2) gene in Salmonella typhimurium isolated from diarrheic pigs in South Korea.
The study identified the plasmid-mediated AmpC beta-lactamase gene CMY-2 in Salmonella Typhimurium isolates from diarrheic pigs in South Korea, highlighting its role in resistance to multiple β-lactam antibiotics.
Resistance determinants and mobile genetic elements of an NDM-1-encoding Klebsiella pneumoniae strain.
The study identifies multiple antibiotic resistance genes in the NDM-1-encoding Klebsiella pneumoniae strain, including eight beta-lactamase genes and various other resistance determinants, highlighting the complexity of its resistance profile.
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
New broad-spectrum β-lactamases emerging among Enterobacteriaceae from healthy cats and dogs: a public health concern?
Whole-Genome Sequence of CMY-2 beta-lactamase-Producing Salmonella enterica Serovar Typhimurium Strain L-3553.
The study reports the whole-genome sequence of Salmonella enterica serovar Typhimurium strain L-3553, which harbors the blaCMY-2 gene responsible for extended-spectrum cephalosporin resistance.
The characterization and antibiotic resistance profiles of clinical Escherichia coli O25b-B2-ST131 isolates in Kuwait.
The study identified bla CTX-M-15, bla CTX-M-2, bla CTX-M-56, qnr B1, qnr S1, bla CMY-2, and aac(6')-Ib-cr as significant AMR genes in E. coli O25b-B2-ST131 isolates in Kuwait. These genes contribute to resistance against various antibiotics including cephalosporins, penicillins, beta-lactamase inhibitors, fluoroquinolones, and aminoglycosides.
Distribution and Diversity of Salmonella Strains in Shipments of Hatchling Poultry, United States, 2013.
The study found that only one isolate of Salmonella Kentucky was resistant to ceftriaxone, and PCR confirmed the presence of the AmpC gene bla CMY-2. Most isolates were pansusceptible or resistant to only tetracycline or streptomycin.
Effect of on-farm use of antimicrobial drugs on resistance in fecal Escherichia coli of preweaned dairy calves.
Enrofloxacin treatment was significantly associated with reduced susceptibility of E. coli to ciprofloxacin and nalidixic acid. Ceftiofur treatment was associated with reduced susceptibility to ceftriaxone and a higher prevalence of multidrug-resistant isolates.
Plasmid-mediated resistance to cephalosporins and fluoroquinolones in various Escherichia coli sequence types isolated from rooks wintering in Europe.
The study identified several plasmid-mediated resistance genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-24, bla TEM-52, bla CTX-M-14, bla CTX-M-55, bla SHV-12, bla CTX-M-8, bla CTX-M-25, bla CTX-M-28, bla CMY-2, qnrS1, qnrB19, and aac(6′)-Ib-cr, in Escherichia coli isolates from rooks in Europe.
Occurrence of Antimicrobial-Resistant Escherichia coli and Salmonella enterica in the Beef Cattle Production and Processing Continuum.
The study identified several AMR genes in E. coli and Salmonella, including beta-lactamase genes (blaCMY, blaCTX-M), sulfonamide resistance genes (sul1, sul2, sul3), and dihydrofolate reductase genes (dfrA1, dfrA5, dfrA7, dfrA12). These genes conferred resistance to various antibiotics such as ampicillin, ceftiofur, ceftriaxone, and trimethoprim-sulfamethoxazole.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
Characterization of Beta-lactamases in Faecal Enterobacteriaceae Recovered from Healthy Humans in Spain: Focusing on AmpC Polymorphisms.
In vivo selection of resistant E. coli after ingestion of milk with added drug residues.
The study found that calves fed milk with low concentrations of antimicrobial drugs had a higher proportion of E. coli resistant to multiple antibiotics, including beta-lactams, aminoglycosides, and tetracyclines. The presence of the bla CMY-2 gene was associated with resistance to ceftiofur and ceftriaxone.
In vivo selection of resistant E. coli after ingestion of milk with added drug residues.
The study found that calves fed milk with low concentrations of antimicrobial drugs had a higher proportion of E. coli resistant to multiple antibiotics, including beta-lactams, aminoglycosides, and tetracyclines. The presence of the bla CMY-2 gene was associated with resistance to ceftiofur and ceftriaxone.
Dissemination of cephalosporin resistance genes between Escherichia coli strains from farm animals and humans by specific plasmid lineages.
The study identified and characterized various cephalosporin resistance genes, including blaCTX-M-1, blaTEM-52, and blaCMY-2, in Escherichia coli strains from humans, poultry, and pigs, highlighting the role of specific plasmid lineages in the dissemination of these resistance genes.
Complete Sequence of Four Multidrug-Resistant MOBQ1 Plasmids Harboring blaGES-5 Isolated from Escherichia coli and Serratia marcescens Persisting in a Hospital in Canada.
Complete Sequence of Four Multidrug-Resistant MOBQ1 Plasmids Harboring blaGES-5 Isolated from Escherichia coli and Serratia marcescens Persisting in a Hospital in Canada.
Complete Sequence of Four Multidrug-Resistant MOBQ1 Plasmids Harboring blaGES-5 Isolated from Escherichia coli and Serratia marcescens Persisting in a Hospital in Canada.
Complete Sequence of Four Multidrug-Resistant MOBQ1 Plasmids Harboring blaGES-5 Isolated from Escherichia coli and Serratia marcescens Persisting in a Hospital in Canada.
Fluoroquinolone-resistant and extended-spectrum β-lactamase-producing Escherichia coli from the milk of cows with clinical mastitis in Southern Taiwan.
The study identified several extended-spectrum beta-lactamase (ESBL) genes including bla TEM, bla CMY, bla CTX, bla SHV, and bla DHA in Escherichia coli isolates from cows with clinical mastitis. Additionally, mutations in gyrA and parC were associated with fluoroquinolone resistance.
Molecular characterization and epidemiology of cefoxitin resistance among Enterobacteriaceae lacking inducible chromosomal ampC genes from hospitalized and non-hospitalized patients in Algeria: description of new sequence type in Klebsiella pneumoniae isolates.
The study identified blaCMY-4 and blaDHA-1 as the primary plasmid-mediated AmpC beta-lactamase genes responsible for cefoxitin resistance in Enterobacteriaceae isolates in Algeria. Additionally, blaTEM-1, qnrB4, and aac(6')-Ib were found to coexist with these genes, contributing to multidrug resistance.
Increase in resistance to extended-spectrum cephalosporins in Salmonella isolated from retail chicken products in Japan.
The study identified the presence of plasmid-mediated extended-spectrum cephalosporin resistance genes, including bla CMY-2, bla CTX-M-2, bla CTX-M-15, bla TEM-20, bla TEM-52, and bla SHV-12, in Salmonella isolates from chicken products in Japan. These genes were associated with resistance to various cephalosporins and other beta-lactam antibiotics.
Extensive amplification of GI-VII-6, a multidrug resistance genomic island of Salmonella enterica serovar Typhimurium, increases resistance to extended-spectrum cephalosporins.
The study identifies blaCMY-2 as a gene responsible for increased resistance to extended-spectrum cephalosporins in Salmonella enterica serovar Typhimurium through gene amplification.
Identification and characterization of multidrug-resistant Salmonella enterica serotype Albert isolates in the United States.
The study identified multidrug-resistant Salmonella enterica serotype Albert isolates carrying the bla CMY-2 gene, which confers resistance to beta-lactam antibiotics, and a chromosomal mutation in gyrA (Ser83Tyr) that reduces susceptibility to quinolones.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases.
The study characterizes the activity of ceftazidime, ceftaroline, and aztreonam in combination with avibactam against isogenic E. coli strains expressing various beta-lactamase genes, demonstrating that avibactam effectively restores the activity of these β-lactams against strains producing class A, C, and D beta-lactamases.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases.
The study characterizes the activity of ceftazidime, ceftaroline, and aztreonam in combination with avibactam against isogenic E. coli strains expressing various beta-lactamase genes, demonstrating that avibactam effectively restores the activity of these β-lactams against strains producing class A, C, and D beta-lactamases.
In Vivo Transmission of an IncA/C Plasmid in Escherichia coli Depends on Tetracycline Concentration, and Acquisition of the Plasmid Results in a Variable Cost of Fitness.
The study shows that high-dose chlortetracycline administration selects for IncA/C plasmid-containing E. coli, while low-dose administration does not. The IncA/C plasmid pAR060302 was found to confer resistance to cephalosporins through the bla CMY-2 gene.
A locked nucleic acid (LNA)-based real-time PCR assay for the rapid detection of multiple bacterial antibiotic resistance genes directly from positive blood culture.
The study developed an LNA-qPCR assay for the rapid detection of 13 antibiotic resistance genes, including bla CTX-M-1, bla CTX-M-9, bla CMY-2, bla DHA-1, bla OXA-23, bla VIM-2, mecA, vanA, and vanB. The assay showed high specificity and sensitivity, with 91.5% concordance with phenotypic susceptibility testing.
Longitudinal study of extended-spectrum-β-lactamase- and AmpC-producing Enterobacteriaceae in household dogs.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla SHV-12, and bla CMY-2, in ESBL-producing Enterobacteriaceae isolated from household dogs. These genes were found to confer resistance to various beta-lactam antibiotics.
Longitudinal study of extended-spectrum-β-lactamase- and AmpC-producing Enterobacteriaceae in household dogs.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla SHV-12, and bla CMY-2, in ESBL-producing Enterobacteriaceae isolated from household dogs. These genes were found to confer resistance to various beta-lactam antibiotics.
Longitudinal study of extended-spectrum-β-lactamase- and AmpC-producing Enterobacteriaceae in household dogs.
Longitudinal study of extended-spectrum-β-lactamase- and AmpC-producing Enterobacteriaceae in household dogs.
Longitudinal study of extended-spectrum-β-lactamase- and AmpC-producing Enterobacteriaceae in household dogs.
Longitudinal study of extended-spectrum-β-lactamase- and AmpC-producing Enterobacteriaceae in household dogs.
Carbapenem-nonsusceptible Enterobacteriaceae in Taiwan.
The study identified several carbapenemase genes, including blaKPC-2, blaIMP-8, blaNDM-1, and blaVIM-1, along with extended-spectrum beta-lactamase genes such as CTX-M, SHV, and ampC beta-lactamase genes like DHA and CMY, which contribute to carbapenem resistance in Enterobacteriaceae isolates in Taiwan.
Clinical epidemiology and molecular analysis of extended-spectrum-β-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types 131 and 648.
The study identified bla CTX-M-15, aac (3)-IIa, aadA1, aadA2, aadA5, qnrB4, qnrS1, aac (6')-Ib-cr, bla OXA-1, bla TEM-1B, bla SHV-12, bla CMY-42, bla DHA-1, mphA, ermB, catA1, catB3, sul1, sul2, dfrA12, dfrA17, dfrA1, dfrA5, tetA, tetB, and tetD as key AMR genes in ESBL-producing E. coli isolates in Nepal, highlighting the prevalence of multidrug resistance.
Two novel CMY-2-type beta-lactamases encountered in clinical Escherichia coli isolates.
This study describes two new bla CMY-2-type genes, bla CMY-46 and bla CMY-50, in E. coli isolates, which confer resistance to several β-lactam antibiotics.
Two novel CMY-2-type beta-lactamases encountered in clinical Escherichia coli isolates.
This study describes two new bla CMY-2-type genes, bla CMY-46 and bla CMY-50, in E. coli isolates, which confer resistance to several β-lactam antibiotics.
Molecular characteristics of extended-spectrum cephalosporin-resistant Enterobacteriaceae from humans in the community.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and others, as well as plasmidic AmpC genes like bla CMY-2 and bla DHA-1, in various Enterobacteriaceae isolates from healthy humans in the community.
Dissemination of the chromosomally encoded CMY-2 cephalosporinase gene in Escherichia coli isolated from animals.
Dissemination of the chromosomally encoded CMY-2 cephalosporinase gene in Escherichia coli isolated from animals.
Dissemination of the chromosomally encoded CMY-2 cephalosporinase gene in Escherichia coli isolated from animals.
Dissemination of the chromosomally encoded CMY-2 cephalosporinase gene in Escherichia coli isolated from animals.
In Vitro Activity of Imipenem and Colistin against a Carbapenem-Resistant Klebsiella pneumoniae Isolate Coproducing SHV-31, CMY-2, and DHA-1.
The study identified the presence of blaSHV-31, blaCMY-2, and blaDHA-1 genes in a carbapenem-resistant K. pneumoniae isolate, along with mutations in ompK35 and loss of ompK36, contributing to resistance against multiple antibiotics.
OXA-372, a novel carbapenem-hydrolysing class D β-lactamase from a Citrobacter freundii isolated from a hospital wastewater plant.
OXA-372, a novel carbapenem-hydrolysing class D β-lactamase from a Citrobacter freundii isolated from a hospital wastewater plant.
OXA-372, a novel carbapenem-hydrolysing class D β-lactamase from a Citrobacter freundii isolated from a hospital wastewater plant.
OXA-372, a novel carbapenem-hydrolysing class D β-lactamase from a Citrobacter freundii isolated from a hospital wastewater plant.
In Vivo Evolution of CMY-2 to CMY-33 beta-lactamase in Escherichia coli Sequence Type 131: Characterization of an Acquired Extended-Spectrum AmpC Conferring Resistance to Cefepime.
The study describes the in vivo evolution of CMY-2 to CMY-33 beta-lactamase in Escherichia coli sequence type 131, demonstrating that CMY-33 confers resistance to cefepime through a Leu293-Ala294 deletion in the H-10 helix.
In Vivo Evolution of CMY-2 to CMY-33 beta-lactamase in Escherichia coli Sequence Type 131: Characterization of an Acquired Extended-Spectrum AmpC Conferring Resistance to Cefepime.
The study describes the in vivo evolution of CMY-2 to CMY-33 beta-lactamase in Escherichia coli sequence type 131, demonstrating that CMY-33 confers resistance to cefepime through a Leu293-Ala294 deletion in the H-10 helix.
Increasing prevalence of ciprofloxacin-resistant food-borne Salmonella strains harboring multiple PMQR elements but not target gene mutations.
The study identified multiple PMQR genes, including aac(6')-Ib-cr, oqxAB, and qnrS, as major contributors to ciprofloxacin resistance in Salmonella strains, along with beta-lactamase genes like bla CTX-M-65, bla CTX-M-55, bla CMY-2, and bla CMY-72. Target gene mutations in gyrA and parC were also observed, although many strains lacked these mutations.
Increasing prevalence of ciprofloxacin-resistant food-borne Salmonella strains harboring multiple PMQR elements but not target gene mutations.
The study identified multiple PMQR genes, including aac(6')-Ib-cr, oqxAB, and qnrS, as major contributors to ciprofloxacin resistance in Salmonella strains, along with beta-lactamase genes like bla CTX-M-65, bla CTX-M-55, bla CMY-2, and bla CMY-72. Target gene mutations in gyrA and parC were also observed, although many strains lacked these mutations.
Increased Hydrolysis of Oximino-β-Lactams by CMY-107, a Tyr199Cys Mutant Form of CMY-2 Produced by Escherichia coli.
The study characterizes CMY-107, a Tyr199Cys mutant of CMY-2, which exhibits increased hydrolytic activity against oximino-β-lactams compared to the wild-type CMY-2 enzyme.
Increased Hydrolysis of Oximino-β-Lactams by CMY-107, a Tyr199Cys Mutant Form of CMY-2 Produced by Escherichia coli.
Increased Hydrolysis of Oximino-β-Lactams by CMY-107, a Tyr199Cys Mutant Form of CMY-2 Produced by Escherichia coli.
Increased Hydrolysis of Oximino-β-Lactams by CMY-107, a Tyr199Cys Mutant Form of CMY-2 Produced by Escherichia coli.
Attributes of carbapenemase encoding conjugative plasmid pNDM-SAL from an extensively drug-resistant Salmonella enterica Serovar Senftenberg.
The study identifies the blaNDM-1 and blaCMY-4 genes on the plasmid pNDM-SAL, which confer resistance to carbapenems and cephalosporins, respectively, in Salmonella enterica serovar Senftenberg and other enteric pathogens.
Cooccurrence of Multiple AmpC beta-lactamases in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis in Tunisia.
The study identifies multiple AmpC beta-lactamase genes, including bla CMY-4, bla CMY-16, bla FOX-3, and bla MOX-2, in clinical isolates of Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis in Tunisia, highlighting the coexistence of these resistance genes in a single strain.
Cooccurrence of Multiple AmpC beta-lactamases in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis in Tunisia.
The study identifies multiple AmpC beta-lactamase genes, including bla CMY-4, bla CMY-16, bla FOX-3, and bla MOX-2, in clinical isolates of Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis in Tunisia, highlighting the coexistence of these resistance genes in a single strain.
Changing plasmid types responsible for extended spectrum cephalosporin resistance in Escherichia coli O157:H7 in the United States, 1996-2009.
The study identifies blaCMY-2 as the primary gene responsible for extended-spectrum cephalosporin resistance in E. coli O157:H7, with plasmid types shifting from IncA/C to IncI1 over time.
Prevalence of extended-spectrum cephalosporin-resistant Escherichia coli in a farrowing farm: ST1121 clone harboring IncHI2 plasmid contributes to the dissemination of bla CMY-2.
The study identifies the bla CMY-2 gene as a significant contributor to extended-spectrum cephalosporin resistance in Escherichia coli isolates from a farrowing farm in Southern China. The gene was found to be carried on an IncHI2 plasmid, which facilitated its dissemination among ST1121 clones.
Detection of ESBL- and AmpC-producing E. coli isolates from urinary tract infections.
The study identified blaTEM and blaCMY-2 genes as responsible for ESBL and AmpC production in E. coli isolates from urinary tract infections, highlighting their role in resistance to cephalosporins and cephamycins.
β-Lactamase Characterization of Gram-Negative Pathogens Recovered from Patients Enrolled in the Phase 2 Trials for Ceftazidime-Avibactam: Clinical Efficacies Analyzed against Subsets of Molecularly Characterized Isolates.
The study characterized β-lactamase genes in baseline pathogens from patients enrolled in phase 2 trials for ceftazidime-avibactam, identifying CTX-M-14, CTX-M-15, OXA-1, TEM-1, OXA-1/30, SHV-12, ACC-4, CMY-42, NDM-1, VIM-2, PER-1, and OXA-23 as key resistance determinants against ceftazidime.
Susceptibility to β-lactams and quinolones of Enterobacteriaceae isolated from urinary tract infections in outpatients.
The study identified bla CMY-2 as a beta-lactamase conferring resistance to third-generation cephalosporins and aac(6')-Ib as an aminoglycoside acetyltransferase conferring resistance to gentamicin. Fluoroquinolone resistance was primarily due to mutations in the QRDR regions of gyrA (S83L, D87N) and parC (S80I).
Seafood as a Reservoir of Gram-negative Bacteria Carrying Integrons and Antimicrobial Resistance Genes in Japan.
Seafood as a Reservoir of Gram-negative Bacteria Carrying Integrons and Antimicrobial Resistance Genes in Japan.
Seafood as a Reservoir of Gram-negative Bacteria Carrying Integrons and Antimicrobial Resistance Genes in Japan.
Seafood as a Reservoir of Gram-negative Bacteria Carrying Integrons and Antimicrobial Resistance Genes in Japan.
Carbapenem-Resistant Bacteria Recovered from Faeces of Dairy Cattle in the High Plains Region of the USA.
The study identified carbapenem-resistant bacteria in dairy cattle faeces, including Escherichia coli with bla CMY-2 and truncated ompF genes, Aeromonas with bla cphA -like genes, Acinetobacter baumannii with a novel bla OXA-497 gene, and Pseudomonas with various carbapenemase-producing genes.
A multi-drug resistant Salmonella Typhimurium ST213 human-invasive strain (33676) containing the bla CMY-2 gene on an IncF plasmid is attenuated for virulence in BALB/c mice.
The study identifies the bla CMY-2 gene on a conjugative IncF plasmid in a multidrug-resistant Salmonella Typhimurium ST213 strain, which is associated with resistance to ceftriaxone and is linked to the strain's reduced virulence in mice.
Identification of emergent bla CMY-2 -carrying Proteus mirabilis lineages by whole-genome sequencing.
The study identifies two clonal lineages of cefoxitin-resistant Proteus mirabilis carrying the bla CMY-2 gene within an integrative and conjugative element, along with additional resistance genes contributing to multidrug resistance.
Plasmid and Host Strain Characteristics of Escherichia coli Resistant to Extended-Spectrum Cephalosporins in the Norwegian Broiler Production.
The study identifies blaCMY-2 as the primary genetic mechanism for cephalosporin resistance in Escherichia coli isolates from Norwegian broiler production, highlighting the role of IncK plasmids in the dissemination of this resistance gene.
Emergence of an NDM-5-producing clinical Escherichia coli isolate in Egypt.
The study reports the first occurrence of NDM-5-producing Escherichia coli in Egypt, highlighting the emergence of carbapenem resistance and the presence of additional resistance genes such as blaCTX-M-15, blaCMY-42, blaOXA-1, and aac(6')-Ib-cr.
Host-Specific Patterns of Genetic Diversity among IncI1-Iγ and IncK Plasmids Encoding CMY-2 beta-lactamase in Escherichia coli Isolates from Humans, Poultry Meat, Poultry, and Dogs in Denmark.
The study characterizes the genetic diversity of IncI1-Iγ and IncK plasmids encoding CMY-2 beta-lactamase in E. coli isolates from various hosts in Denmark, highlighting the role of these plasmids in the spread of β-lactam resistance.
Extended-Spectrum Cephalosporin-Resistant Salmonella enterica serovar Heidelberg Strains, the Netherlands
The study identifies blaCMY-2, blaCTX-M-2, blaCTX-M-1, and blaCTX-M-14 as the primary genes responsible for extended-spectrum cephalosporin resistance in Salmonella enterica serovar Heidelberg isolates in the Netherlands.
Veterinary Hospital Dissemination of CTX-M-15 Extended-Spectrum Beta-Lactamase-Producing Escherichia coli ST410 in the United Kingdom.
The study identified bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla TEM-1, bla OXA-1, bla CMY-2, and aac(6')-Ib - cr as the primary AMR genes in ESC-resistant E. coli isolates from UK companion animals. These genes were associated with resistance to multiple antibiotics including beta-lactams and quinolones.
Evidence of household transfer of ESBL-/pAmpC-producing Enterobacteriaceae between humans and dogs - a pilot study.
The study identified bla CTX-M-27, bla CMY-2, and bla TEM-1 as the resistance genes responsible for extended-spectrum cephalosporin resistance in Enterobacteriaceae isolated from humans and dogs in the same households.
Fecal Colonization with Extended-Spectrum Beta-Lactamase and AmpC-Producing Escherichia coli.
The study identified ES β L and AmpC-producing E. coli isolates in fecal samples, with bla CTX-M-15 being the most prevalent gene. The isolates showed resistance to various β -lactam antibiotics.
Prevalence and Diversity of Salmonella Serotypes in Ecuadorian Broilers at Slaughter Age.
The study identified the presence of bla CTX-M, bla TEM, bla SHV, and bla CMY genes in cefotaxime-resistant Salmonella isolates, as well as the mcr-1 gene in colistin-resistant isolates. S. Infantis showed high resistance rates to multiple antibiotics, including sulfamethoxazole, nalidixic acid, and ciprofloxacin.
Streaming algorithms for identification of pathogens and antibiotic resistance potential from real-time MinION(TM) sequencing.
The study presents a real-time analysis framework for MinION sequencing data, demonstrating the ability to identify pathogens and antibiotic resistance genes within a few hours of sequencing. Key resistance genes identified include blaSHV, mphA, strA, strB, blaTEM, sul2, blaOXA, aac3, aac6, blaCMY, blaCFE, blaLAT, blaBIL, QnrB, aadA, oqxA, tetA, oqxB, rmtC, sul1, sul3, fosA, blaNDM, oqxA, blaSHV, oqxB, aadB, sul1, sul3, blaOXA, blaOKP, fosA, blaSHV, blaOKP, blaLEN, oqxA, and oqxB.
Occurrence of OXA-48 Carbapenemase and Other β-Lactamase Genes in ESBL-Producing Multidrug Resistant Escherichia coli from Dogs and Cats in the United States, 2009-2013.
The study identified the presence of various β-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-123, bla CTX-M-9, bla CTX-M-14, bla TEM-1, bla SHV-12, bla CMY-2, and bla OXA-48, in ESBL-producing multidrug resistant E. coli isolates from dogs and cats in the United States. Additionally, the PMQR gene aac(6')-Ib-cr was found to be prevalent in these isolates.
Citrobacter freundii carrying blaKPC-2 and blaNDM-1: characterization by whole genome sequencing.
The study characterizes a Citrobacter freundii strain carrying both blaKPC-2 and blaNDM-1, which confer high-level carbapenem resistance. Additionally, blaCMY-137, a novel CMY enzyme, was identified and functionally validated.
Increased prevalence of antibiotic-resistant E. coli in gulls sampled in Southcentral Alaska is associated with urban environments.
The study found that antibiotic-resistant E. coli isolates from gulls in urban areas of Southcentral Alaska had higher resistance rates compared to those from remote areas, with specific beta-lactamase genes like bla CTX-M-15, bla TEM-1, and bla CMY-2 being identified.
Extended-Spectrum-Beta-Lactamase- and Plasmid-Encoded Cephamycinase-Producing Enterobacteria in the Broiler Hatchery as a Potential Mode of Pseudo-Vertical Transmission.
The study identified several beta-lactamase genes, including TEM-1, TEM-52, CTX-M1, CTX-M15, CMY-2, SHV-1, and SHV-2, which confer resistance to various beta-lactam antibiotics in ESBL-/pAmpC-producing enterobacteria isolated from broiler parent flocks and hatchery environments.
Acquisition of Carbapenem Resistance by Plasmid-Encoded-AmpC-Expressing Escherichia coli.
The study identifies bla_CMY-2 as a plasmid-encoded AmpC beta-lactamase that contributes to carbapenem resistance in E. coli through increased expression, and mutations in ompC and inc that enhance resistance.
High Prevalence of β-lactamase and Plasmid-Mediated Quinolone Resistance Genes in Extended-Spectrum Cephalosporin-Resistant Escherichia coli from Dogs in Shaanxi, China.
The study identified a high prevalence of β-lactamase and plasmid-mediated quinolone resistance genes in extended-spectrum cephalosporin-resistant Escherichia coli from dogs in Shaanxi, China. Key genes included bla CTX-M-15, bla TEM-1, bla SHV-12, and aac(6')-Ib-cr, along with other β-lactamase and PMQR genes.
Emergence of CMY-2- and DHA-1-type AmpC beta-lactamases in Enterobacter cloacae isolated from several hospitals of Qazvin and Tehran, Iran.
The study identified the emergence of bla DHA-1 and bla CMY-2 genes in clinical isolates of Enterobacter cloacae in Iran, indicating the presence of plasmid-mediated AmpC beta-lactamases conferring resistance to cefoxitin.
High Prevalence of Faecal Carriage of ESBL-Producing Enterobacteriaceae among Children in Dar es Salaam, Tanzania.
The study identified bla CTX-M-15 as the predominant ESBL gene in ESBL-producing Enterobacteriaceae isolates from children in Dar es Salaam, Tanzania. Additionally, bla SHV-5/12 and bla CMY-2 were also detected in some isolates.
High Prevalence of Gut Microbiota Colonization with Broad-Spectrum Cephalosporin Resistant Enterobacteriaceae in a Tunisian Intensive Care Unit.
The study identified various AMR genes including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CMY-2, bla OXA-48, bla NDM-1, qnrB1, qnrS1, and qnrA6 in CTX-R Enterobacteriaceae isolates from ICU patients in Tunisia.
Antimicrobial usage and resistance in beef production.
The review discusses the impact of antimicrobial usage in beef production on the emergence and spread of antimicrobial resistance (AMR) in bovine pathogens. It highlights the role of antimicrobial use in promoting AMR, particularly in respiratory and liver abscess pathogens, and emphasizes the need for judicious use to mitigate risks to both animal and human health.
Antimicrobial usage and resistance in beef production.
The review discusses the impact of antimicrobial usage in beef production on the emergence and spread of antimicrobial resistance (AMR) in bovine pathogens. It highlights the role of antimicrobial use in promoting AMR, particularly in respiratory and liver abscess pathogens, and emphasizes the need for judicious use to mitigate risks to both animal and human health.
Clinical and microbiologic characteristics of cefotaxime-non-susceptible Enterobacteriaceae bacteremia: a case control study.
The study identified several beta-lactamase genes, including CTX-M-14, CTX-M-27, CTX-M-15, CTX-M-55, CTX-M-2, SHV-12, SHV-27, DHA-1, and CMY-2, which confer resistance to cephalosporins in cefotaxime-non-susceptible Enterobacteriaceae isolates.
Antibacterial Activities and Possible Modes of Action of Acacia nilotica (L.) Del. against Multidrug-Resistant Escherichia coli and Salmonella.
The study identified beta-lactam resistance gene bla CMY and tetracycline resistance genes tet (A) and tet (B) in multidrug-resistant E. coli and Salmonella isolates.
Virulent nontyphoidal Salmonella producing CTX-M and CMY-2 beta-lactamases from livestock, food and human infection, Brazil.
The study identifies virulent nontyphoidal Salmonella strains producing CTX-M and CMY-2 beta-lactamases from various sources in Brazil, highlighting the role of IncI1 plasmids in the dissemination of these resistance genes.
Panel strain of Klebsiella pneumoniae for beta-lactam antibiotic evaluation: their phenotypic and genotypic characterization.
The study characterizes various AMR genes and mutations in K. pneumoniae panel strains, including beta-lactamases (bla SHV-11, bla TEM-1, bla CTX-M15, bla OXA-1, bla SHV-12, bla SHV-187, bla SHV-158, bla DHA-1, bla CMY-2), aminoglycoside modifying enzymes (aac(6')-Ib, strA, strB, aadA1, aadA2), quinolone resistance genes (qnrB66, qnrB4, oqxA, oqxB), tetracycline resistance (tet(A)), trimethoprim resistance (dfrA14), sulfonamide resistance (sul1, sul2), and porin genes (OmpK35, OmpK36).
A Whole-Genome Sequencing Approach To Study Cefoxitin-Resistant Salmonella enterica Serovar Heidelberg Isolates from Various Sources.
The study identified the bla CMY-2 gene as the primary determinant of cefoxitin resistance in Salmonella enterica serovar Heidelberg isolates from various sources.
Detection of SGI1/PGI1 Elements and Resistance to Extended-Spectrum Cephalosporins in Proteae of Animal Origin in France.
The study identified several beta-lactamase genes, including blaVEB-6, blaCTX-M-1, blaCTX-M-15, blaCMY-2, and blaDHA-16, which confer resistance to extended-spectrum cephalosporins in Proteae isolates from animals in France.
Antibiotic-Resistant Extended Spectrum ß-Lactamase- and Plasmid-Mediated AmpC-Producing Enterobacteriaceae Isolated from Retail Food Products and the Pearl River in Guangzhou, China.
The study identified various beta-lactamase genes, including blaSHV-1, blaTEM-1, blaCTX-M-55, blaCTX-M-65, blaDHA-1, blaCMY-2, blaACC-1, and blaCIT, which confer resistance to multiple beta-lactam antibiotics in Enterobacteriaceae isolated from retail food and water samples in Guangzhou, China.
Resistance to antimicrobial drugs in different surface waters and wastewaters of Guadeloupe.
The study identified several AMR genes including blaCTX-M, blaSHV, blaTEM, qnrB19, qnrB1, aac(6')-Ib-cr, VEB-1, CMY-2, and CMY-8 in Enterobacteriaceae isolates from surface waters and wastewaters in Guadeloupe. These genes conferred resistance to various antibiotics such as ceftazidime, cefotaxime, ampicillin, ciprofloxacin, gentamicin, and cefoxitin.
Whole-Genome Sequencing of Drug-Resistant Salmonella enterica Isolates from Dairy Cattle and Humans in New York and Washington States Reveals Source and Geographic Associations.
The study identified several AMR genes and mutations in Salmonella enterica isolates from dairy cattle and humans in New York and Washington States, highlighting the role of geographic and source-specific factors in AMR dissemination.
Transfer Potential of Plasmids Conferring Extended-Spectrum-Cephalosporin Resistance in Escherichia coli from Poultry.
The study identifies blaCMY-2 as a gene conferring resistance to extended-spectrum cephalosporins and demonstrates the transferability of plasmids carrying this gene between E. coli and Serratia species under various conditions relevant to broiler production.
Distribution of Integrons and Phylogenetic Groups among Enteropathogenic Escherichia coli Isolates from Children <5 Years of Age in Delhi, India.
The study identified various AMR genes including dfrA1, dfrA7, dfrA12, aadA1, aadA2, sul1, tetA, aacC1, TEM, SHV, CTX-M, OXA, NDM-1, IMP, VIM, ACT, DHA, and CMY in E. coli isolates from children in Delhi, India. These genes were associated with resistance to multiple antibiotics such as trimethoprim, streptomycin, sulfonamides, tetracycline, gentamicin, and various beta-lactams.
Genotypic and phenotypic characterization of multidrug resistant Salmonella Typhimurium and Salmonella Kentucky strains recovered from chicken carcasses.
The study identified multidrug-resistant Salmonella Typhimurium and Kentucky strains from chicken carcasses, highlighting the presence of resistance genes such as blaCMY-2, tetRA, and a mercury resistance operon.
Uncovering Differences in Virulence Markers Associated with Achromobacter Species of CF and Non-CF Origin.
The study identified the presence of the blaCMY-2 gene, which encodes an AmpC beta-lactamase, in two non-CF Achromobacter isolates, indicating resistance to cefoxitin.
Detection and drug resistance profile of Escherichia coli from subclinical mastitis cows and water supply in dairy farms in Saraburi Province, Thailand.
The study identified several AMR genes in E. coli isolates from subclinical mastitis cows and water supplies, including blaTEM, blaCMY-2, and aac(3)-IIa, which confer resistance to beta-lactams and aminoglycosides.
Characterization of a blaNDM‑1‑harboring plasmid from a Salmonella enterica clinical isolate in China.
The study characterizes a blaNDM-1-harboring plasmid from a Salmonella enterica clinical isolate in China, identifying multiple resistance genes including blaNDM-1, blaCMY-6, dfrA12, aadA2, rmtC, qacEΔ1, sul1, and bleMBL.
Occurrence of the mcr-1 Colistin Resistance Gene and other Clinically Relevant Antibiotic Resistance Genes in Microbial Populations at Different Municipal Wastewater Treatment Plants in Germany.
The study identified the mcr-1 colistin resistance gene and several other clinically relevant antibiotic resistance genes, including ermB, tetM, CTX-M, CTX-M-32, blaTEM, and CMY-2, in wastewater treatment plant samples in Germany.
Klebsiella pneumoniae Isolates from Meningitis: Epidemiology, Virulence and Antibiotic Resistance.
The study identified several beta-lactamase genes (blaSHV-5, blaTEM-1B, blaCMY-2, and blaDHA-1) associated with resistance to cefotaxime and ceftazidime in Klebsiella pneumoniae isolates from meningitis. These genes were predominantly found in post-craniotomy meningitis isolates.
Evolving beta-lactamase epidemiology in Enterobacteriaceae from Italian nationwide surveillance, October 2013: KPC-carbapenemase spreading among outpatients.
The study identified the prevalence of beta-lactamase genes, including bla CTX-M-1, bla CTX-M-9, bla KPC, bla VIM, bla OXA-48, and bla NDM, in Enterobacteriaceae isolates from Italy. It highlighted the increasing spread of CTX-M-type enzymes and KPC-carbapenemase among outpatients.
Horizontal Dissemination of Antimicrobial Resistance Determinants in Multiple Salmonella Serotypes following Isolation from the Commercial Swine Operation Environment after Manure Application.
The study identified various antimicrobial resistance genes, including bla_CMY-2, bla_TEM, aadA2, tet(A), tet(B), sul1, and sul2, in multiple Salmonella serotypes isolated from swine farm environments. These genes were found on plasmids and contributed to resistance against beta-lactams, aminoglycosides, tetracyclines, and sulfonamides.
Molecular determination of antimicrobial resistance in Escherichia coli isolated from raw meat in Addis Ababa and Bishoftu, Ethiopia.
The study identified several AMR genes in E. coli isolates from raw meat, including blaCMY, tet(A), and sul1, which confer resistance to beta-lactams, tetracyclines, and sulfonamides, respectively.
Comparative Sequence Analysis of Multidrug-Resistant IncA/C Plasmids from Salmonella enterica.
The study identified multiple antimicrobial resistance genes on IncA/C plasmids from various Salmonella serovars, including bla_cmy-2, bla_tem-1, strA, strB, aadB, aph(3')-Ia, tetA, floR, cmlA, sul1, sul2, dfra12, quacE, sugE, merA, merB, merC, merD, and merE, which contribute to multidrug resistance.
Rapid Nanopore Sequencing of Plasmids and Resistance Gene Detection in Clinical Isolates.
The study demonstrates the feasibility of rapid nanopore sequencing for detecting plasmid-borne antimicrobial resistance (AMR) genes in clinical isolates. It identifies several AMR genes, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, tetracycline resistance genes, macrolide resistance genes, and phenicol resistance genes, in both Escherichia coli and Klebsiella pneumoniae isolates.
A comparison of extended spectrum beta-lactamase producing Escherichia coli from clinical, recreational water and wastewater samples associated in time and location.
The study identifies several beta-lactamase genes (bla CTX-M-15, bla CTX-M-14, bla SHV-12, bla CMY-58) and the plasmid-borne colistin resistance gene mcr-1 in ESBL-EC from recreational water, wastewater, and clinical samples. These genes contribute to resistance against β-lactam antibiotics and colistin.
Population dynamics of enteric Salmonella in response to antimicrobial use in beef feedlot cattle.
The study found that the blaCMY-2 gene was associated with resistance to multiple antimicrobials, including ceftiofur, ceftriaxone, ampicillin, amoxicillin-clavulanic acid, cephalothin, and cefoxitin in Salmonella enterica isolates.
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting.
The study identified various AMR genes and mutations in E. coli isolates from children with cystic fibrosis, cancer, and healthy controls, highlighting differences in resistance profiles between groups.
Co-Occurrence of Plasmid-Mediated AmpC beta-lactamase Activity Among Klebsiella pneumoniae and Escherichia Coli.
The study identified plasmid-mediated AmpC beta-lactamase genes, including bla CMY, bla MOX, bla DHA, and bla EBC, in Klebsiella pneumoniae and Escherichia coli isolates from Libya. These genes conferred resistance to cefoxitin and cefepime.
Environmental adaptation and vertical dissemination of ESBL-/pAmpC-producing Escherichia coli in an integrated broiler production chain in the absence of an antibiotic treatment.
The study identified blaCMY-2 and blaSHV-12 genes in ESBL-/pAmpC-producing E. coli isolates from broiler production chains, highlighting their role in beta-lactam resistance.
Characterization of plasmids harboring blaCTX-M and blaCMY genes in E. coli from French broilers.
The study characterized blaCTX-M-1 and blaCMY-2 genes in E. coli isolates from French broilers, highlighting their roles in extended-spectrum cephalosporin resistance and the presence of virulence genes on blaCMY-2-containing plasmids.
In Vivo Transfer and Microevolution of Avian Native IncA/C(2)bla(NDM-1)-Carrying Plasmid pRH-1238 during a Broiler Chicken Infection Study.
The study identified the bla_NDM-1 gene on the IncA/C2 plasmid pRH-1238, which was transferred to various Enterobacteriaceae, including E. coli and K. pneumoniae, demonstrating its broad host range and resistance to carbapenems.
Comprehensive Molecular Characterization of Escherichia coli Isolates from Urine Samples of Hospitalized Patients in Rio de Janeiro, Brazil.
The study identified various AMR genes including blaCTX-M-15, blaCTX-M-8, blaCMY-2, blaKPC-2, blaOXA-1, and blaTEM-1B in E. coli isolates from hospitalized patients in Rio de Janeiro, Brazil. These genes were associated with resistance to multiple antibiotics, highlighting the presence of multidrug-resistant clones.
Comprehensive Evaluation of the MBT STAR-BL Module for Simultaneous Bacterial Identification and beta-lactamase-Mediated Resistance Detection in Gram-Negative Rods from Cultured Isolates and Positive Blood Cultures.
The study evaluated the MBT STAR-BL module for detecting beta-lactamase-mediated resistance in Gram-negative rods from cultured isolates and blood cultures. It identified several beta-lactamase genes, including blaTEM-1b, blaCTX-M-13, blaCTX-M-14, blaNDM-5, blaKPC-2, blaCMY-2, blaOXA-23, blaOXA-51, blaVIM-4, blaPOM-1, and blaL1, which confer resistance to various β-lactam antibiotics.
Time to acquire and lose carriership of ESBL/pAmpC producing E. coli in humans in the Netherlands.
The study characterizes the acquisition and loss of carriership of ESBL/pAmpC-producing E. coli, identifying specific genes such as bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla SHV-12, and bla CMY-2 as being involved in resistance to various beta-lactam antibiotics.
Genetic Environment of bla(TEM-1), bla(CTX-M-15), bla(CMY-42) and Characterization of Integrons of Escherichia coli Isolated From an Indian Urban Aquatic Environment.
The study characterizes the genetic environment of bla TEM-1, bla CTX-M-15, and bla CMY-42 in E. coli isolates from an Indian urban aquatic environment, identifying the presence of IS 26, IS Ecp1, and class 1 integrons.
Prediction of Phenotypic Antimicrobial Resistance Profiles From Whole Genome Sequences of Non-typhoidal Salmonella enterica.
The study identified various AMR genes and mutations in non-typhoidal Salmonella enterica, including blaTEM-1, strA-strB, sul2, tet(A), qnrS1, aadA2, aadA17, floR, cmlA1, aac(3)-Id, aac(3)-IIa, dfrA12, dfrA1, dfrA14, blaCTX-M-9, blaCTX-M-55, blaSHV-12, blaPSE-1/blaCARB-2, and blaCMY-2, along with mutations in gyrA and parC associated with ciprofloxacin resistance.
Serotype Diversity and Antimicrobial Resistance among Salmonella enterica Isolates from Patients at an Equine Referral Hospital.
The study identified various AMR genes in Salmonella enterica isolates from equine patients, including beta-lactamases, aminoglycoside modifying enzymes, and genes conferring resistance to tetracyclines, macrolides, and other antibiotics.
Acquisition and dissemination of cephalosporin-resistant E. coli in migratory birds sampled at an Alaska landfill as inferred through genomic analysis.
The study identified various beta-lactam resistance genes, including bla CTX-M-55, bla CTX-M-14, and bla CMY-2, in cephalosporin-resistant E. coli isolates from gulls and bald eagles in Alaska. These genes were found to confer resistance to beta-lactam antibiotics.
What does the fox say? Monitoring antimicrobial resistance in the environment using wild red foxes as an indicator.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CMY, bla CTX-M-1, bla CTX-M-14, and bla CTX-M-15, in Escherichia coli isolates from wild red foxes, highlighting the presence of antimicrobial resistance associated with human population density.
Faecal colonization of E. coli and Klebsiella spp. producing extended-spectrum beta-lactamases and plasmid-mediated AmpC in Mozambican university students.
The study identified various extended-spectrum beta-lactamase (ESBL) and plasmid-mediated AmpC (pAmpC) genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-186, bla DHA, bla MOX, bla FOX, and bla CMY, in E. coli and Klebsiella spp. isolates from Mozambican university students.
A pan-genome-based machine learning approach for predicting antimicrobial resistance activities of the Escherichia coli strains.
The study identifies and characterizes several AMR genes in E. coli, including beta-lactamases (blaTEM-1, blaOXA-1, blaCMY-2, ampC), aminoglycoside modifying enzymes (aac(3')-Ia, aac(3')-VI), dihydrofolate reductases (dfrA1, dfrA5, dfrA12, dfrA15), quinolone resistance proteins (qnrB2, qnrB6, qnrS2), and others. These genes were validated through computational and wet lab methods, showing their roles in conferring resistance to various antibiotics.
Multidrug-resistant Citrobacter freundii ST139 co-producing NDM-1 and CMY-152 from China.
The study identifies a multidrug-resistant Citrobacter freundii strain co-producing NDM-1 and CMY-152, along with other resistance genes such as bla VEB-3, bla TEM-1, qnrS1, and others, highlighting the complex resistance mechanisms in this isolate.
Antimicrobial Resistance in Nontyphoidal Salmonella.
The study characterizes the presence of bla CMY genes and qnrS1 in Salmonella, which confer resistance to extended-spectrum cephalosporins and ciprofloxacin, respectively.
Genomic Characterization of MDR Escherichia coli Harboring bla(OXA-48) on the IncL/M-type Plasmid Isolated from Blood Stream Infection.
The study identified multiple AMR genes, including blaOXA-48, blaCTX-M-3, blaTEM-1B, blaOXA-1, aac(3)-IId, tet(A), tet(R), and blaCMY-70, in an MDR E. coli isolate. It also detected mutations in gyrA (S83L, D87N) and parC (S80I) contributing to fluoroquinolone resistance.
ISEcp1-mediated transposition of chromosome-borne bla(CMY-2) into an endogenous ColE1-like plasmid in Escherichia coli.
The study reports the first instance of IS Ecp1-mediated transposition of the chromosomally encoded bla(CMY-2) gene into an endogenous ColE1-like plasmid in Escherichia coli, leading to increased resistance to extended-spectrum cephalosporins.
Whole genome analyses of CMY-2-producing Escherichia coli isolates from humans, animals and food in Germany.
The study identified bla CMY-2 as a significant contributor to beta-lactam resistance in E. coli isolates from humans, animals, and food in Germany. The gene was found to be widely distributed and often associated with specific plasmid replicon types such as IncK2 and IncI1.
Selection of mutants with resistance or diminished susceptibility to ceftazidime/avibactam from ESBL- and AmpC-producing Enterobacteriaceae.
Selection of mutants with resistance or diminished susceptibility to ceftazidime/avibactam from ESBL- and AmpC-producing Enterobacteriaceae.
Selection of mutants with resistance or diminished susceptibility to ceftazidime/avibactam from ESBL- and AmpC-producing Enterobacteriaceae.
Selection of mutants with resistance or diminished susceptibility to ceftazidime/avibactam from ESBL- and AmpC-producing Enterobacteriaceae.
Characterization of Salmonella enterica serovars recovered from meat products legally and illegally imported into the EU reveals the presence of multiresistant and AmpC-producing isolates.
The study identifies multiresistant Salmonella enterica isolates from legally and illegally imported meat, including AmpC-producing isolates carrying blaCMY-2, tet(A), and sul2 genes, which confer resistance to cephalosporins, tetracycline, and sulfonamides.
Antimicrobial Resistance in ESBL-Producing E. coli Isolates from Companion Animals
The study identifies several novel beta-lactamase genes, including bla_SFO, bla_Cph, bla_VIM, bla_Act, bla_MIR, bla_MOX, and bla_PAO, along with commonly encountered genes like bla_CTX-M-15, bla_TEM-1B, and bla_OXA-1, in ESBL-producing E. coli isolates from companion animals.
Transcriptome analysis of extended-spectrum beta-lactamase-producing Escherichia coli and methicillin-resistant Staphylococcus aureus exposed to cefotaxime.
The study identifies and characterizes the beta-lactamase genes bla CTX-M-15, bla CMY-2, mecA, and blaZ as the primary mechanisms of cefotaxime resistance in the studied strains of Escherichia coli and Staphylococcus aureus.
The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis.
The study characterized the resistomes of six carbapenem-resistant pathogens, identifying various carbapenemase genes such as bla KPC-2, bla OXA-48, bla OXA-72, bla NDM-1, bla NDM-7, and bla VIM-1, along with other resistance genes like aac(6')-Ib-cr, aph(3")-Ib, aph(6)-Id, tet(B), erm(B), mph(A), sul1, sul2, dfrA17, dfrA14, bla CTX-M-15, bla CMY-6, bla OXA-1, bla SHV-200, bla OXA-10, and bla NDM-7.
Zoonotic multidrug-resistant microorganisms among small companion animals in Germany.
The study identified ESBL-producing Enterobacteriaceae and MRSA in companion animals, highlighting the presence of beta-lactam resistance genes such as bla TEM, bla CTX-M, bla SHV, and bla CMY-2, as well as methicillin resistance genes mecA and mecC in various staphylococcal species.
Travel to Asia is a strong predictor for carriage of cephalosporin resistant E. coli and Klebsiella spp. but does not explain everything; prevalence study at a Norwegian hospital 2014-2016.
The study identified bla CTX-M-15, bla CTX-M-55, bla CTX-M-27, bla OXA-1, bla CTX-M-14, bla CTX-M-1, bla CTX-M-3, bla TEM-33, bla DHA-1, and bla CMY-42 as the main genes responsible for extended-spectrum cephalosporin resistance in E. coli and Klebsiella spp. Travel to Asia was a strong predictor for carriage of these resistant strains.
Whole genome sequence analysis of NDM-1, CMY-4, and SHV-12 coproducing Salmonella enterica serovar Typhimurium isolated from a case of fatal burn wound infection.
The study reports the first case of a carbapenem-resistant and MBL (NDM-1), ESBL (SHV-12), and AmpC beta-lactamase (CMY-4) coproducing Salmonella Typhimurium isolated from a fatal burn wound infection.
Acquisition of plasmid-mediated cephalosporinase producing Enterobacteriaceae after a travel to the tropics.
The study identified CMY-2, CMY-42, CMY-6, and DHA plasmid-mediated cephalosporinase genes in Enterobacteriaceae acquired by travelers to tropical regions, with CMY-2 being the most prevalent. New variants CMY-2m and CMY-42m were also discovered.
Acquisition of plasmid-mediated cephalosporinase producing Enterobacteriaceae after a travel to the tropics.
The study identified CMY-2, CMY-42, CMY-6, and DHA plasmid-mediated cephalosporinase genes in Enterobacteriaceae acquired by travelers to tropical regions, with CMY-2 being the most prevalent. New variants CMY-2m and CMY-42m were also discovered.
Acquisition of plasmid-mediated cephalosporinase producing Enterobacteriaceae after a travel to the tropics.
The study identified CMY-2, CMY-42, CMY-6, and DHA plasmid-mediated cephalosporinase genes in Enterobacteriaceae acquired by travelers to tropical regions, with CMY-2 being the most prevalent. New variants CMY-2m and CMY-42m were also discovered.
Genomic and Virulence Characterization of Intrauterine Pathogenic Escherichia coli With Multi-Drug Resistance Isolated From Cow Uteri With Metritis.
The study identified multiple beta-lactamase genes, including bla CTX-M, bla CMY, bla TEM, and ampC, in intrauterine pathogenic E. coli (IUPEC) isolates from cows with metritis, which conferred resistance to cephalosporins like cefotaxime and ceftiofur.
Prevalence, risk factors, and characterization of multidrug resistant and extended spectrum β-lactamase/AmpC β-lactamase producing Escherichia coli in healthy horses in France in 2015.
The study identified bla CTX-M-1, bla CTX-M-2, bla CTX-M-14, bla SHV-12, and bla CMY-2 as the primary beta-lactamase genes responsible for extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase production in Escherichia coli isolates from healthy horses in France. These genes conferred resistance to various beta-lactam antibiotics, including ceftiofur, ceftriaxone, and cefoxitin.
Antimicrobial resistance of Escherichia coli and Enterococcus spp. isolated from Estonian cattle and swine from 2010 to 2015.
The study identified bla CMY-1, bla CMY-2, and bla TEM-52C genes in E. coli isolates from Estonian cattle and swine, indicating resistance to beta-lactam antibiotics. High levels of resistance to various antibiotics were observed in E. coli and Enterococcus spp. from both animal sources.
Extensive drug resistant Salmonella enterica serovar Senftenberg carrying blaNDM encoding plasmid p5558 (IncA/C) from India.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Salmonella enterica serovar Senftenberg isolate, including blaNDM-1, blaTEM-1, blaOXA-9, blaCMY-2, aac(6')-Ia, aac(6')-Ib, aph(3')-Ib, aph(6')-Ib, ant(3'')-Ia, sul-1, sul-2, and florR. Additionally, mutations in gyrA (S83Y, D87G) and parC (S80I) were associated with fluoroquinolone resistance.
High level of multidrug-resistant Escherichia coli in young dairy calves in southern Vietnam.
The study identified multidrug-resistant Escherichia coli in young dairy calves in southern Vietnam, including bla CTX-M-1, bla CTX-M-9, bla CMY-2, and qnrS genes associated with resistance to various antibiotics.
Circulation of Plasmids Harboring Resistance Genes to Quinolones and/or Extended-Spectrum Cephalosporins in Multiple Salmonella enterica Serotypes from Swine in the United States.
The study identifies multiple plasmid-mediated resistance genes in Salmonella enterica serotypes from swine in the United States, including qnrB19, qnrB2, qnrB15, qnrD, qnrS1, qnrS2, aac(6')-Ib-cr, bla CMY-2, bla CTX-M-1, bla CTX-M-27, and bla SHV-12, which confer resistance to quinolones and extended-spectrum cephalosporins.
Diversity of Plasmids and Genes Encoding Resistance to Extended Spectrum Cephalosporins in Commensal Escherichia coli From Dutch Livestock in 2007-2017.
The study identified 22 different ESBL/pAmpC genes in commensal E. coli from Dutch livestock, with bla CTX-M-1 being the most prevalent. Other notable genes included bla CMY-2, bla TEM-52, bla SHV-12, and bla CTX-M-15. The study also highlighted the role of plasmids in the dissemination of these resistance genes.
Genetic, Biochemical, and Structural Characterization of CMY-136 β-Lactamase, a Peculiar CMY-2 Variant.
Genetic, Biochemical, and Structural Characterization of CMY-136 β-Lactamase, a Peculiar CMY-2 Variant.
Transcriptome analysis of beta-lactamase genes in diarrheagenic Escherichia coli.
Fate of CMY-2-Encoding Plasmids Introduced into the Human Fecal Microbiota by Exogenous Escherichia coli.
The study demonstrates that CMY-2-encoding IncI1 plasmids can transfer to the human fecal microbiota at low inoculum concentrations, highlighting the potential for exogenous E. coli to disseminate antibiotic resistance genes.
Prevalence of antimicrobial resistance and potential pathogenicity, and possible spread of third generation cephalosporin resistance, in Escherichia coli isolated from healthy chicken farms in the region of Dakar, Senegal.
The study identified various AMR genes and mutations in E. coli isolates from healthy chicken farms in Senegal, including bla CTX-M, bla CMY-2, tetA, dfrA1, dfrA7, aadA1, qnrB, and bla TEM, as well as mutations in gyrA and parC genes contributing to ciprofloxacin resistance.
Pathogenic potential and the role of clones and plasmids in beta-lactamase-producing E. coli from chicken faeces in Vietnam.
The study identified bla CTX-M and bla CMY-2 genes as the primary mechanisms of third-generation cephalosporin resistance in E. coli isolates from chicken faeces in Vietnam. Additionally, mutations in the gyrA and parC genes were found to contribute to ciprofloxacin resistance.
Characterization of cefotaxime resistant Escherichia coli isolated from broiler farms in Ecuador.
The study identified bla CTX-M-65, bla CTX-M-55, bla CTX-M-3, bla CMY-2, and mcr-1 as the primary resistance genes in cefotaxime-resistant E. coli isolates from broiler farms in Ecuador.
Effect of Cessation of Ceftiofur and Substitution with Lincomycin-Spectinomycin on Extended-Spectrum-β-Lactamase/AmpC Genes and Multidrug Resistance in Escherichia coli from a Canadian Broiler Production Pyramid.
The study found that the cessation of ceftiofur use led to a decrease in the prevalence of bla CMY-2 and bla CTX-M genes in E. coli from broiler chickens, but the replacement with lincomycin-spectinomycin increased multidrug resistance.
Antimicrobial Usages and Antimicrobial Resistance in Commensal Escherichia coli From Veal Calves in France: Evolution During the Fattening Process.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-32, bla CTX-M-55, bla CTX-M-3, and bla CTX-M-2, as well as the plasmid-mediated mcr-1 gene, which confers resistance to colistin. These genes were prevalent in commensal Escherichia coli from veal calves in France.
Genomic Investigation of the Emergence of Invasive Multidrug-Resistant Salmonella enterica Serovar Dublin in Humans and Animals in Canada.
The study identifies multiple AMR genes and mutations in multidrug-resistant Salmonella enterica serovar Dublin isolates from Canada, highlighting the role of IS 26 in plasmid hybridization and the emergence of MDR strains.
Genomic Comparison Reveals Natural Occurrence of Clinically Relevant Multidrug-Resistant Extended-Spectrum-β-Lactamase-Producing Escherichia coli Strains.
The study identifies CTX-M and CMY-2 beta-lactamase genes in multidrug-resistant E. coli strains from beef cattle, highlighting their role in resistance to cephalosporins.
Global phylogenomics of multidrug-resistant Salmonella enterica serotype Kentucky ST198.
The study identifies multiple AMR genes and mutations in multidrug-resistant Salmonella enterica serotype Kentucky ST198, including genes such as blaTEM-1, aacA4, aadA1, sul1, tetA, catA1, mph(A), blaCTX-M-1, blaOXA-48, blaNDM-1, blaCMY-2, and dfrA12, along with mutations in gyrA and parC that confer resistance to various antibiotics.
Diverse Commensal Escherichia coli Clones and Plasmids Disseminate Antimicrobial Resistance Genes in Domestic Animals and Children in a Semirural Community in Ecuador.
The study identified various antimicrobial resistance (AMR) genes in commensal Escherichia coli isolates from children and domestic animals in a semirural community in Ecuador. These genes included blaTEM-1B, dfrA8, qnrB19, strA, strB, tetA, tetB, sul1, sul2, and others, contributing to resistance against multiple antibiotics such as ampicillin, trimethoprim, tetracycline, and sulfamethoxazole. The research highlights the role of plasmids in disseminating these AMR genes and emphasizes the complexity of AMR transmission in such environments.
Direct use of eazyplex(®) SuperBug CRE assay from positive blood cultures in conjunction with inpatient infectious disease consulting for timely appropriate antimicrobial therapy in Escherichia coli and Klebsiella pneumoniae bloodstream infections.
The study highlights the effectiveness of the eazyplex® SuperBug CRE assay in detecting bla CTX-M, bla KPC, and bla VIM genes in Escherichia coli and Klebsiella pneumoniae bloodstream infections, enabling timely and appropriate antimicrobial therapy.
Antibiotic Resistance of E. coli Isolated From a Constructed Wetland Dominated by a Crow Roost, With Emphasis on ESBL and AmpC Containing E. coli.
The study identified bla ctx-M and bla cmy-2 genes as major contributors to extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase resistance in E. coli isolates from a constructed wetland dominated by a crow roost. Tetracycline resistance was primarily mediated by tet (A), tet (B), and tet (M), while streptomycin resistance was linked to strA, strB, and aadA. Sulfamethoxazole/trimethoprim resistance was associated with the sul1 gene.
Metal impacts on the persistence and proliferation of β-lactam resistance genes in Xiangjiang River, China.
The study identifies and characterizes the persistence and proliferation of various β-lactam resistance genes (blaTEM, blaVIM, blaSHV, blaGES, blaDHA, blaOXA-1, blaOXA-2, blaOXA-10, blaCMY-2, and blaampC) in the Xiangjiang River, highlighting the impact of heavy metals on their distribution and the role of bacterial communities in their persistence.
Carriage of carbapenemase- and extended-spectrum cephalosporinase-producing Escherichia coli and Klebsiella pneumoniae in humans and livestock in rural Cambodia; gender and age differences and detection of bla(OXA-48) in humans.
The study identified various beta-lactamase genes such as bla CTX-M27, bla CTX-M55, bla CTX-M15, bla CTX-M14, bla CMY-2, bla CMY-42, bla SHV-2, bla SHV-12, bla SHV-28, bla SHV-1, bla DHA-1, and bla OXA-48, along with colistin resistance genes mcr-1-like and mcr-3-like in Escherichia coli and Klebsiella pneumoniae isolates from humans and livestock in Cambodia.
Carriage of carbapenemase- and extended-spectrum cephalosporinase-producing Escherichia coli and Klebsiella pneumoniae in humans and livestock in rural Cambodia; gender and age differences and detection of bla(OXA-48) in humans.
The study identified various beta-lactamase genes such as bla CTX-M27, bla CTX-M55, bla CTX-M15, bla CTX-M14, bla CMY-2, bla CMY-42, bla SHV-2, bla SHV-12, bla SHV-28, bla SHV-1, bla DHA-1, and bla OXA-48, along with colistin resistance genes mcr-1-like and mcr-3-like in Escherichia coli and Klebsiella pneumoniae isolates from humans and livestock in Cambodia.
Dissemination of Multidrug-Resistant Commensal Escherichia coli in Feedlot Lambs in Southeastern Brazil.
The study identified multiple multidrug-resistant commensal E. coli isolates in feedlot lambs in Brazil, carrying various AMR genes including bla CTX-M-2, bla CTX-M-8, bla CTX-M-14, bla CTX-M-15, bla CMY-2, aac(3)-IIa, ant(2")-Ia, qnrB, tetA, tetB, sul1, sul2, floR, and cmlA. These genes confer resistance to beta-lactams, aminoglycosides, quinolones, tetracyclines, sulfonamides, and phenicols.
Characterization and whole genome sequencing of closely related multidrug-resistant Salmonella enterica serovar Heidelberg isolates from imported poultry meat in the Netherlands.
The study identified blaCMY-2, qnrB19, blaCTX-M-2, blaCTX-M-8, and blaTEM-1B as key resistance genes in multidrug-resistant Salmonella enterica serovar Heidelberg isolates from imported poultry meat in the Netherlands. Mutations in gyrA (S83F) and parC (T57S) were also linked to ciprofloxacin and nalidixic acid resistance.
Effects of two-dose ceftiofur treatment for metritis on the temporal dynamics of antimicrobial resistance among fecal Escherichia coli in Holstein-Friesian dairy cows.
Two-dose ceftiofur treatment for metritis in dairy cows leads to increased levels of third-generation cephalosporin (3GC) resistance among fecal Escherichia coli, primarily due to the presence of bla CMY-2 and bla CTX-M-32 genes.
Characterization of CMY-2-type beta-lactamase-producing Escherichia coli isolated from chicken carcasses and human infection in a city of South Brazil.
The study identified the bla CMY-2 gene in all pAmpC-producing E. coli strains isolated from chicken carcasses and human infections, highlighting its role in resistance to cephalosporins.
Genomic Features of High-Priority Salmonella enterica Serovars Circulating in the Food Production Chain, Brazil, 2000-2016.
The study identified several AMR genes in Salmonella enterica isolates from Brazil, including qnrE1, qnrB19, qnrS1, blaCTX-M-2, blaCTX-M-8, blaCMY-2, aadA1, aadA2, aac(3)-IVa, aac(3)-IIa, aac(6')-Ib, floR, sul1, sul2, tet(A), tet(B), strA, strB, drfA1, inu(F), qacEdelta1, and fosA7. These genes conferred resistance to various antibiotics such as fluoroquinolones, beta-lactams, aminoglycosides, sulfonamides, tetracyclines, chloramphenicol, trimethoprim, macrolides, quaternary ammonium compounds, and fosfomycin.
Identification of Primary Antimicrobial Resistance Drivers in Agricultural Nontyphoidal Salmonella enterica Serovars by Using Machine Learning.
The study identifies CMY-2 beta-lactamase as a primary driver of beta-lactam resistance and APH(6)-Id and APH(3"-Ib as key contributors to streptomycin and tetracycline resistance in agricultural Nontyphoidal Salmonella enterica serovars.
Horizontal Gene Transfer and Acquired Antibiotic Resistance in Salmonella enterica Serovar Heidelberg following In Vitro Incubation in Broiler Ceca.
The study identifies the acquisition of the blaCMY-2 gene on an IncK2 plasmid by Salmonella enterica serovar Heidelberg, leading to resistance against cephalosporins and penicillins.
Dissemination prevention of antibiotic resistant and facultative pathogenic bacteria by ultrafiltration and ozone treatment at an urban wastewater treatment plant.
The study analyzed the effectiveness of ultrafiltration and ozone treatment in reducing antibiotic resistance genes (ARGs) and facultative pathogenic bacteria in wastewater. It identified several ARGs, including sul1, blaTEM, tetM, CTX-M, CTX-M-32, blaOXA-48, blaVIM, CMY-2, vanA, mcr-1, blaNDM, ermB, and intl1, which were found to be prevalent in the wastewater. Both ultrafiltration units showed significant reduction in these ARGs and pathogenic bacteria, whereas ozone treatment was less effective.
Development of an algorithm to discriminate between plasmid- and chromosomal-mediated AmpC beta-lactamase production in Escherichia coli by elaborate phenotypic and genotypic characterization.
The study identifies bla CMY-2 and bla DHA-1 as the primary plasmid-mediated AmpC beta-lactamase genes responsible for resistance to third-generation cephalosporins in E. coli. An algorithm based on cefotaxime MIC values was developed to distinguish between plasmid-mediated and chromosomal-mediated AmpC production.
Detection of multidrug resistance and extended-spectrum/plasmid-mediated AmpC beta-lactamase genes in Enterobacteriaceae isolates from diseased cats in Italy.
The study identified various beta-lactamase genes, including CTX-M-1, CTX-M-2, CTX-M-9, CTX-M-79, SHV-12, TEM-92, and CMY-2, which confer resistance to third-generation cephalosporins in Enterobacteriaceae isolates from diseased cats in Italy.
Emergence and transmission of New Delhi metallo-beta-lactamase-5-producing Escherichia coli Sequence Type 361 in a Tertiary Hospital in South Korea.
The study reports an outbreak of NDM-5-producing E. coli ST361 in a South Korean hospital, highlighting the multidrug-resistant nature of these isolates and the presence of additional resistance genes such as qepA, blaTEM-1, blaCMY-2, blaCTX-M-15, and aac(6')-Ib-cr.
Prevalence of Beta-Lactam and Quinolone/Fluoroquinolone Resistance in Enterobacteriaceae From Dogs in France and Spain-Characterization of ESBL/pAmpC Isolates, Genes, and Conjugative Plasmids.
The study identified several beta-lactam resistance genes, including bla CTX-M-1, bla CTX-M-15, bla SHV-12, and bla CMY-2, in Enterobacteriaceae from dogs in France and Spain. These genes were associated with resistance to cefotaxime and were carried on various conjugative plasmids.
Occurrence of and risk factors for extended-spectrum cephalosporin-resistant Enterobacteriaceae determined by sampling of all Norwegian broiler flocks during a six month period.
The study identified bla CMY, bla CTX-M-1, bla CTX-M-15, and bla SHV-12 as the primary resistance genes in extended-spectrum cephalosporin-resistant Enterobacteriaceae from Norwegian broiler flocks.
Multidrug-Resistant Escherichia coli, Klebsiella pneumoniae and Staphylococcus spp. in Houseflies and Blowflies from Farms and Their Environmental Settings.
The study identified bla CMY-2 and bla CTXM-1 as extended-spectrum beta-lactamase (ESBL) genes in Escherichia coli and Klebsiella pneumoniae isolated from flies, highlighting the role of flies in the environmental spread of antimicrobial resistance.
Genetic characterization of a novel sequence type of multidrug-resistant Citrobacter freundii strain recovered from wastewater treatment plant.
The study reports the identification of a multidrug-resistant Citrobacter freundii strain R17 carrying 13 antibiotic-resistance genes, including blaCMY-85, aadA2, aac(3)-lld, blaDHA-1, blaTEM-1B, qnrB4, mph(A), catA2, sul1, sul2, tet(D), and dfrA12, which confer resistance to various antibiotic classes.
Shedding of OXA-181 carbapenemase-producing Escherichia coli from companion animals after hospitalisation in Switzerland: an outbreak in 2018.
The study identified the carbapenemase gene blaOXA-181, the quinolone resistance gene qnrS1, the cephalosporinase gene blaCMY-42, and the tetracycline resistance gene tet(A) in carbapenemase-producing Escherichia coli isolates from companion animals in Switzerland. Additionally, chromosomal mutations in GyrA and ParC were associated with high-level fluoroquinolone resistance.
Characterization of Beta-Lactamases in Bloodstream-Infection Escherichia coli: Dissemination of bla(ADC) (-) (162) and bla(CMY-) (2) Among Bacteria via an IncF Plasmid.
The study characterizes beta-lactamase genes in bloodstream-infection Escherichia coli, identifying blaTEM-1, blaCTX-M-14, blaCTX-M-27, blaCTX-M-55, blaCTX-M-65, blaOXA-30, blaCMY-2, and blaADC-162 as prevalent. These genes were found to be disseminated via IncF plasmids, highlighting their role in multidrug resistance.
Determining the Virulence Properties of Escherichia coli ST131 Containing Bacteriocin-Encoding Plasmids Using Short- and Long-Read Sequencing and Comparing Them with Those of Other E. coli Lineages.
The study identified the beta-lactamase gene bla CMY-2 on a plasmid in E. coli ST131 isolates, which confers resistance to cefoxitin and cefotaxime. The presence of this gene along with bacteriocin-encoding plasmids may enhance the competitiveness and virulence of these isolates.
Detection and identification of a protein biomarker in antibiotic-resistant Escherichia coli using intact protein LC offline MALDI-MS and MS/MS.
The study identifies a DNA-binding HU protein as a biomarker correlated with β-lactam resistance in E. coli, which is likely translated from the bla CMY-2 gene located on the IncA/C plasmid.
In vitro selection of aztreonam/avibactam resistance in dual-carbapenemase-producing Klebsiella pneumoniae.
The study identified mutations in the bla CMY-16 gene (Tyr150Ser and Asn346His) that confer resistance to aztreonam/avibactam in dual-carbapenemase-producing Klebsiella pneumoniae.
Genetic Diversity of CMY Beta-Lactamase Genes in Clinical Isolates of Escherichia coli in Myanmar: Identification of Three Novel Types and Updated Phylogenetic Classification of bla(CMY).
Genetic Diversity of CMY Beta-Lactamase Genes in Clinical Isolates of Escherichia coli in Myanmar: Identification of Three Novel Types and Updated Phylogenetic Classification of bla(CMY).
Genetic Diversity of CMY Beta-Lactamase Genes in Clinical Isolates of Escherichia coli in Myanmar: Identification of Three Novel Types and Updated Phylogenetic Classification of bla(CMY).
Genetic Diversity of CMY Beta-Lactamase Genes in Clinical Isolates of Escherichia coli in Myanmar: Identification of Three Novel Types and Updated Phylogenetic Classification of bla(CMY).
Genetic Diversity of CMY Beta-Lactamase Genes in Clinical Isolates of Escherichia coli in Myanmar: Identification of Three Novel Types and Updated Phylogenetic Classification of bla(CMY).
Genetic Diversity of CMY Beta-Lactamase Genes in Clinical Isolates of Escherichia coli in Myanmar: Identification of Three Novel Types and Updated Phylogenetic Classification of bla(CMY).
Genetic Diversity of CMY Beta-Lactamase Genes in Clinical Isolates of Escherichia coli in Myanmar: Identification of Three Novel Types and Updated Phylogenetic Classification of bla(CMY).
LMB-1 producing Citrobacter freundii from Argentina, a novel player in the field of MBLs.
LMB-1 producing Citrobacter freundii from Argentina, a novel player in the field of MBLs.
LMB-1 producing Citrobacter freundii from Argentina, a novel player in the field of MBLs.
LMB-1 producing Citrobacter freundii from Argentina, a novel player in the field of MBLs.
Type 1, 2, and 1/2-Hybrid IncC Plasmids From China.
The study identifies several beta-lactamase genes (bla CMY-6, bla CTX-M-3, bla CTX-M-14, bla IMP-8, bla NDM-1) and a sulfonamide resistance gene (sul2) in various IncC plasmids from China. These genes confer resistance to multiple antibiotics, including cephalosporins, carbapenems, and sulfonamides.
Molecular Detection Of Multidrug-Resistant Salmonella Isolated From Livestock Production Systems In South Africa.
The study identified multiple multidrug-resistant Salmonella isolates from livestock in South Africa, highlighting the presence of resistance genes such as blaTEM-1, blaCMY-2, tetA, tetC, sul2, and dfrA7.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
High occurrence of CMY-2-type beta-lactamase-producing Escherichia coli among broiler flocks in Turkey.
The study identified blaCMY-2 as the most prevalent beta-lactamase gene among ESBL/pAmpC-producing E. coli isolates from broiler flocks in Turkey, highlighting its significance in antimicrobial resistance.
Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania.
The study identified the presence of blaCTX-M-15 and blaCMY-42 genes in E. coli isolates, indicating resistance to ceftazidime. These genes were found in various sources including livestock, humans, and the environment in Tanzania.
Phenotypic and molecular characterization of antimicrobial resistant Escherichia coli from urinary tract infections in Port-Harcourt, Nigeria.
The study identified multiple antimicrobial resistance genes in E. coli isolates from urinary tract infections in Port-Harcourt, Nigeria, including blaTEM, blaCTX-M-15, blaSHV, blaOXA-1, blaCMY-2, qnrD, qnrS, aac(6')-Ib, and aacC2. These genes were associated with resistance to various antibiotics, highlighting the complexity of multidrug resistance in these isolates.
Complete Nucleotide Sequence of Plasmids of Two Escherichia coli Strains Carrying bla (NDM-) (5) and bla (NDM) (-) (5) and bla (OXA) (-) (181) From the Same Patient.
The study characterizes two carbapenemase-producing E. coli strains carrying blaNDM-5 and blaOXA-181, along with various other resistance genes such as qnrS1, blaCTX-M-15, aac(6')-lb-cr, catB3, sul1, dfrA17, qacEΔ1, aadA5, rmtB, ermB, mphA, tetB, catA1, dfrA14, dfrA12, blaTEM-1B, and blaCMY-42.
Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.
The study identifies known and novel antimicrobial resistance genes using a machine learning approach on pan-genomes of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Key findings include the detection of resistance genes such as gyrA, parC, ermC, lmrS, aac(6')-aph(2"), dfrG, tetK, and various beta-lactamases.
Molecular and Clinical Characterization of Multidrug-Resistant and Hypervirulent Klebsiella pneumoniae Strains from Liver Abscess in Taiwan.
Systematic Evaluation of Whole Genome Sequence-Based Predictions of Salmonella Serotype and Antimicrobial Resistance.
The study evaluated the performance of various bioinformatics tools for predicting antimicrobial resistance (AMR) and serotypes of Salmonella enterica using whole-genome sequencing (WGS). It identified several AMR genes and mutations associated with resistance to various antibiotics.
Low occurrence of extended-spectrum cephalosporinase producing Enterobacteriaceae and no detection of methicillin-resistant coagulase-positive staphylococci in healthy dogs in Sweden.
The study found that 0.9% of healthy dogs in Sweden carried multidrug-resistant ESBL-producing E. coli, with the isolates harboring various blaCTX-M genes, including blaCTX-M-1, blaCTX-M-55, and blaCTX-M-27. No methicillin-resistant coagulase-positive staphylococci were detected.
Pathotypes and Antimicrobial Susceptibility of Escherichia Coli Isolated from Wild Boar (Sus scrofa) in Tuscany.
The study identified various antimicrobial resistance genes in E. coli isolates from wild boar in Tuscany, including blaCMY-2, sul1, sul2, tetG, aadA1, and strA-strB, indicating significant resistance to beta-lactams, sulfonamides, tetracyclines, and streptomycin.
Deadly Puppy Infection Caused by an MDR Escherichia coli O39 bla (CTX-M-15), bla (CMY-2), bla (DHA-1), and aac(6)-Ib-cr - Positive in a Breeding Kennel in Central Italy.
The study characterizes an MDR E. coli O39 strain carrying multiple AMR genes including bla CTX-M-15, bla CMY-2, bla DHA-1, and aac(6')-Ib-cr, highlighting the complexity of the resistome in this outbreak.
Molecular Characterization of Fecal Extended-Spectrum beta-lactamase- and AmpC beta-lactamase-Producing Escherichia coli From Healthy Companion Animals and Cohabiting Humans in South Korea.
The study identified bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, and bla CMY-2 as the most prevalent ESBL/AmpC resistance genes in fecal E. coli isolates from healthy companion animals and cohabiting humans in South Korea. The bla CMY-2 gene was found to be chromosomally located and its expression level was correlated with the copy number of the gene.
A prospective study of bloodstream infections among febrile adolescents and adults attending Yangon General Hospital, Yangon, Myanmar.
The study identified bla CTX-M-15, bla NDM-5, and bla CMY-42 as key beta-lactamase genes contributing to antimicrobial resistance in Enterobacteriaceae isolates from bloodstream infections in Myanmar. Fluoroquinolone resistance was primarily due to mutations in the quinolone resistance-determining region.
Comparative Genomic Analysis of Third-Generation-Cephalosporin-Resistant Escherichia coli Harboring the blaCMY-2-Positive IncI1 Group, IncB/O/K/Z, and IncC Plasmids Isolated from Healthy Broilers in Japan.
The study identified blaCMY-2 as the primary gene responsible for third-generation cephalosporin resistance in Escherichia coli isolates from healthy broilers in Japan, highlighting its prevalence and the role of specific plasmid types in its dissemination.
Pathogenic Escherichia coli in Dogs Reveals the Predominance of ST372 and the Human-Associated ST73 Extra-Intestinal Lineages.
The study identified several beta-lactamase genes, including bla CTX-M-15, bla CTX-M-27, bla CTX-M-1, bla CTX-M-3, bla CMY-2, and bla OXA-48, which confer resistance to various beta-lactam antibiotics in E. coli isolates from dogs.
Antimicrobial Resistance Profiles of Adherent Invasive Escherichia coli Show Increased Resistance to β-Lactams.
An Unusual Carbapenem Resistant Escherichia coli Carrying Plasmid-mediated AmpC and Mutated ompC in A Patient with Recurrent Urinary Tract Infections.
The study identifies a carbapenem-resistant E. coli isolate carrying the plasmid-mediated AmpC gene blaCMY-2 and multiple mutations in the ompC gene, leading to reduced porin levels and carbapenem resistance.
In vitro conjugation kinetics of AmpC, broad spectrum and extended-spectrum beta-lactamase-producing Escherichia coli donors and various Enterobacteriaceae recipients.
The study characterizes several beta-lactamase genes (blaCTX-M-1, blaCTX-M-15, blaSHV-12, blaTEM-52, blaTEM-1, and blaCMY-2) that confer resistance to ceftazidime and cefotaxime in Escherichia coli donors, highlighting their role in conjugation and horizontal gene transfer among Enterobacteriaceae.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
The study identifies multiple AMR genes and mutations in MDR E. coli strains from captive wild animals, highlighting the presence of CTX-M-8 and CTX-M-65 beta-lactamases, along with various other resistance mechanisms such as aminoglycoside, tetracycline, and fluoroquinolone resistance genes, as well as mutations in quinolone resistance-determining regions.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
The study identified multiple AMR genes and mutations in E. coli isolates from diseased chickens in the Czech Republic, highlighting the presence of multidrug-resistant strains with resistance to β-lactams, quinolones, sulfonamides, and tetracyclines.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
The study identified multiple AMR genes and mutations in E. coli isolates from diseased chickens in the Czech Republic, highlighting the presence of multidrug-resistant strains with resistance to β-lactams, quinolones, sulfonamides, and tetracyclines.
Decreased detection of ESBL- or pAmpC-producing Escherichia coli in broiler breeders imported into Sweden.
The study reports the decrease in detection of ESBL- or pAmpC-producing E. coli in broiler breeders imported into Sweden, with specific identification of bla CMY-2, bla CTX-M-1, and bla SHV-12 genes as responsible for resistance.
Reservoirs of antimicrobial resistance genes in retail raw milk.
The study identifies multiple antimicrobial resistance genes in retail raw milk, including bla CMY-2, aph (3')-Ib, aph (6)-Id, bla TEM-1B, mdf(A), catA2, sul2, tet(B), and dfrA14, which confer resistance to various antibiotics. These genes were found in E. coli and other bacteria, and some were transferable between species.
Reservoirs of antimicrobial resistance genes in retail raw milk.
The study identifies multiple antimicrobial resistance genes in retail raw milk, including bla CMY-2, aph (3')-Ib, aph (6)-Id, bla TEM-1B, mdf(A), catA2, sul2, tet(B), and dfrA14, which confer resistance to various antibiotics. These genes were found in E. coli and other bacteria, and some were transferable between species.
Genomic analyses of multidrug-resistant Salmonella Indiana, Typhimurium, and Enteritidis isolates using MinION and MiSeq sequencing technologies.
The study identified various AMR genes in multidrug-resistant Salmonella isolates, including beta-lactamases (blaCTX-M-14, blaCTX-M-27, blaCTX-M-55, blaOXA-1, blaCMY-2, blaOXA, blaCMY), phenicol resistance genes (catB3, cmlA1, floR, catA1, catA2, oqxA, oqxB), aminoglycoside resistance genes (aac(6')-Ib-cr5, aac(6')-Ib-cr, oqxA2, qepA1, qnrS1), sulfonamide and trimethoprim resistance genes (sul1, sul2, sul3, dfrA12, dfrA7), and tetracycline resistance genes (tet(A), tet(B), tet(M)).
Genomic analyses of multidrug-resistant Salmonella Indiana, Typhimurium, and Enteritidis isolates using MinION and MiSeq sequencing technologies.
The study identified various AMR genes in multidrug-resistant Salmonella isolates, including beta-lactamases (blaCTX-M-14, blaCTX-M-27, blaCTX-M-55, blaOXA-1, blaCMY-2, blaOXA, blaCMY), phenicol resistance genes (catB3, cmlA1, floR, catA1, catA2, oqxA, oqxB), aminoglycoside resistance genes (aac(6')-Ib-cr5, aac(6')-Ib-cr, oqxA2, qepA1, qnrS1), sulfonamide and trimethoprim resistance genes (sul1, sul2, sul3, dfrA12, dfrA7), and tetracycline resistance genes (tet(A), tet(B), tet(M)).
Whole Genome Sequencing and Characterization of Multidrug-Resistant (MDR) Bacterial Strains Isolated From a Norwegian University Campus Pond.
The study identifies multiple AMR genes and mutations in ESBL-producing bacteria from Norwegian freshwater environments, highlighting the presence of multidrug-resistant strains with resistance to various antibiotics including beta-lactams, fluoroquinolones, and sulfonamides.
The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2016.
The report highlights high levels of antimicrobial resistance in zoonotic bacteria such as Salmonella and Campylobacter, with specific emphasis on resistance to fluoroquinolones, tetracyclines, and sulfonamides. It also notes the emergence of multidrug-resistant strains and the presence of ESBL-producing and carbapenemase-producing E. coli in poultry and meat.
The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2017.
The report highlights high levels of antimicrobial resistance in zoonotic bacteria such as Salmonella and Campylobacter, as well as in indicator bacteria like Escherichia coli. Key findings include resistance to multiple antibiotics, including extended-spectrum beta-lactamases (ESBLs), AmpC beta-lactamases, and carbapenemases. Colistin resistance was observed at low levels, and multidrug-resistant strains were prevalent in certain serovars.
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
The study identified multiple AMR genes, including bla CTX-M-55, bla CMY-2, bla CTX-M-1, bla SHV-12, sul2, aac(3)-Ia, aadA, strA, strB, tet(A), tet(B), dfrA14, floR, cmlA1, catA1, catB3, qnrS1, qnrS2, qnrB19, mph(A), mph(B), arr-3, and aac(6')Ib-cr, in ESBL/pAmpC-producing E. coli isolates from broiler production.
Antibiotic Administration Routes and Oral Exposure to Antibiotic Resistant Bacteria as Key Drivers for Gut Microbiota Disruption and Resistome in Poultry.
The study found that oral administration of ampicillin led to a significant increase in the bla CMY–2 gene pool in poultry feces, highlighting the role of antibiotic administration routes in gut microbiota disruption and resistome changes.
Mobility of β-Lactam Resistance Under Bacterial Co-infection and Ampicillin Treatment in a Mouse Model.
The study identified β-lactam resistance genes including bla CMY–2, bla CTX–M–1, and bla TEM–1B in Escherichia coli O80:H26 and Salmonella strains, demonstrating their transferability under ampicillin treatment in a mouse model.
Conjugative plasmidic AmpC detected in Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae human clinical isolates from Portugal.
The study detected plasmidic AmpC genes (blaCIT, blaCMY, and blaDHA) in clinical isolates of Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae from Portugal, confirming their role in β-lactam resistance through PCR and phenotypic analysis.
High Prevalence and Diversity of Cephalosporin-Resistant Enterobacteriaceae Including Extraintestinal Pathogenic E. coli CC648 Lineage in Rural and Urban Dogs in Northwest Spain.
The study identified a high prevalence of cephalosporin-resistant Enterobacteriaceae in dogs from rural and urban areas in Galicia, Spain, including various ESBL and pAmpC genes such as blaCTX-M-1, blaCTX-M-14, blaCTX-M-15, and others. These genes were found in E. coli and K. pneumoniae isolates, contributing to multidrug resistance.
High Prevalence and Diversity of Cephalosporin-Resistant Enterobacteriaceae Including Extraintestinal Pathogenic E. coli CC648 Lineage in Rural and Urban Dogs in Northwest Spain.
The study identified a high prevalence of cephalosporin-resistant Enterobacteriaceae in dogs from rural and urban areas in Galicia, Spain, including various ESBL and pAmpC genes such as blaCTX-M-1, blaCTX-M-14, blaCTX-M-15, and others. These genes were found in E. coli and K. pneumoniae isolates, contributing to multidrug resistance.
High Prevalence and Diversity of Cephalosporin-Resistant Enterobacteriaceae Including Extraintestinal Pathogenic E. coli CC648 Lineage in Rural and Urban Dogs in Northwest Spain.
The study identified a high prevalence of cephalosporin-resistant Enterobacteriaceae in dogs from rural and urban areas in Galicia, Spain, including various ESBL and pAmpC genes such as blaCTX-M-1, blaCTX-M-14, blaCTX-M-15, and others. These genes were found in E. coli and K. pneumoniae isolates, contributing to multidrug resistance.
Molecular Relatedness of Salmonella enterica Typhimurium Isolates from Feces and an Infected Surgical Wound.
The study identified the presence of blaCTX-M-15, blaTEM-1, qnrS-1, qnrB, aac-3, and blaCMY-2 in Salmonella enterica serovar Typhimurium isolates SM043 and SM080, which conferred resistance to third- and fourth-generation cephalosporins and other antibiotics.
F Plasmids Are the Major Carriers of Antibiotic Resistance Genes in Human-Associated Commensal Escherichia coli.
The study identifies various antibiotic resistance genes in commensal E. coli isolates, highlighting the prevalence of resistance genes on F plasmids and the role of mobile genetic elements in their dissemination.
Understanding the Mechanisms of Antimicrobial Resistance in Enteric Pathogens
The paper discusses various antimicrobial resistance mechanisms in enteric bacteria, highlighting the role of beta-lactamases, mcr genes, and erm genes in conferring resistance to beta-lactams, colistin, and macrolides respectively.
Antibiotic Susceptibility Testing (AST) Reports: A Basis for Environmental/Epidemiological Surveillance and Infection Control Amongst Environmental Vibrio cholerae.
The study identified various antibiotic resistance genes in Vibrio cholerae isolates, including blaTEM, NDM-1, AmpC, and ESBL, indicating multidrug resistance in environmental V. cholerae.
Characterization and Source Investigation of Multidrug-Resistant Salmonella Anatum from a Sustained Outbreak, Taiwan.
The study identifies blaDHA-1, qnrB, and blaCMY-2 as key AMR genes in multidrug-resistant Salmonella Anatum isolates from a sustained outbreak in Taiwan.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2017/2018.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, focusing on Salmonella, Campylobacter, and E. coli. It notes high resistance levels to ampicillin, sulfonamides, and tetracyclines in Salmonella and E. coli isolates, along with rising resistance to fluoroquinolones in certain serovars. Carbapenemase-producing E. coli and Salmonella were rarely detected.
Resistance to extended-spectrum cephalosporins in Escherichia coli and other Enterobacterales from Canadian turkeys.
The study identified bla CMY-2, bla CTX-M-1, bla CTX-M-55, and bla CTX-M-65 as the primary extended-spectrum cephalosporin resistance genes in Enterobacterales from Canadian turkeys. bla CMY-2 was the most prevalent, while bla CTX-M genes were found on various plasmids, including IncI1, IncF, and IncK.
Benchmarking hybrid assembly approaches for genomic analyses of bacterial pathogens using Illumina and Oxford Nanopore sequencing.
The study compared hybrid assembly approaches for bacterial pathogen genomes and identified AMR genes such as blaZ, msr(A), and tet(K) in Staphylococcus aureus.
Resistance Profiling and Molecular Characterization of Extended-Spectrum/Plasmid-Mediated AmpC beta-lactamase-Producing Escherichia coli Isolated from Healthy Broiler Chickens in South Korea.
The study identified ESBL/pAmpC-producing E. coli isolates from healthy broiler chickens in South Korea, highlighting the presence of bla CTX-M-14, bla CTX-M-55, and bla CMY-2 genes, as well as coexistence of mcr-1 and bla CMY-2 genes, indicating significant antimicrobial resistance concerns.
Escherichia coli Sequence Type 457 Is an Emerging Extended-Spectrum-β-Lactam-Resistant Lineage with Reservoirs in Wildlife and Food-Producing Animals.
The study identifies multiple AMR genes, including bla CMY-2, bla CTX-M-8, bla CTX-M-27, bla CTX-M-55, mcr-5, and bla OXA-23, in E. coli ST457 strains from various sources, highlighting their role in resistance to β-lactams, colistin, and carbapenems.
Clinical and molecular characteristics of carbapenem non-susceptible Escherichia coli: A nationwide survey from Oman.
The study identified various carbapenemase genes, including blaNDM-5, blaNDM-1, blaNDM-4, blaNDM-7, blaOXA-181, and blaOXA-48, along with extended-spectrum beta-lactamase CTX-M-15, ampC beta-lactamase CMY-42, and penicillinases TEM-1B and OXA-1 in carbapenem-non-susceptible Escherichia coli isolates from Oman.
Antibiotic resistance and virulence of Escherichia coli strains isolated from animal rendering plant.
The study identified CTX-M1, CMY-2, integrase 1, and Tn3 genes in E. coli strains from a rendering plant, contributing to resistance against various beta-lactam antibiotics. Additionally, multidrug-resistant O25b-ST131 clones with CMY-2 and enrofloxacin resistance were detected.
Pathogenicity of Shiga Toxin Type 2e Escherichia coli in Pig Colibacillosis.
The study identified ESBL genes TEM, CTX-M1, and CMY-2 in Stx2e-producing E. coli isolates from diseased pigs, highlighting the prevalence of antimicrobial resistance.
Molecular Epidemiology of Escherichia coli Producing CTX-M and pAmpC beta-lactamases from Dairy Farms Identifies a Dominant Plasmid Encoding CTX-M-32 but No Evidence for Transmission to Humans in the Same Geographical Region.
The study identified bla CTX-M-32 as the most common 3GC-R gene in E. coli isolates from dairy farms, with no evidence of transmission to humans in the same geographical region. Other 3GC-R genes detected include bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-214, bla DHA-1, and bla CMY-2.
American Crows as Carriers of Extra Intestinal Pathogenic E. coli and Avian Pathogenic-Like E. coli and Their Potential Impact on a Constructed Wetland.
The study identifies several AMR genes, including blaCMY-2, blaCTX-M, tet(A), tet(B), strA, and strB, in E. coli isolates from crows and wetland water, highlighting the potential for these genes to be transferred via plasmids and contributing to the spread of antibiotic resistance.
Multidrug-Resistant CTX-M and CMY-2 Producing Escherichia coli Isolated from Healthy Household Dogs from the Great Metropolitan Area, Costa Rica.
The study identified multidrug-resistant E. coli isolates from healthy household dogs in Costa Rica, harboring CTX-M and CMY-2 beta-lactamase genes, which confer resistance to cephalosporins.
Genetic Determinants of Resistance to Extended-Spectrum Cephalosporin and Fluoroquinolone in Escherichia coli Isolated from Diseased Pigs in the United States.
The study identified bla CMY-2, bla CTX-M, and bla SHV-12 genes as major contributors to extended-spectrum cephalosporin resistance, along with qnrB77, qnrB2, qnrS1, qnrS2, and aac(6')-Ib-cr for fluoroquinolone resistance. The colistin resistance gene mcr-9 was also detected in several isolates.
Detection of CMY-type beta-lactamases in Escherichia coli isolates from paediatric patients in a tertiary care hospital in Mexico.
The study detected CMY-type beta-lactamases in 4.5% of E. coli isolates from paediatric patients in Mexico, including CMY-2 and CMY-42 variants. These enzymes confer resistance to various beta-lactam antibiotics.
Struggle To Survive: the Choir of Target Alteration, Hydrolyzing Enzyme, and Plasmid Expression as a Novel Aztreonam-Avibactam Resistance Mechanism.
The study identifies bla CMY-42 as a gene that confers slightly reduced susceptibility to aztreonam-avibactam. Additionally, insertions in the pbp3 gene that result in four extra amino acids (YRIK) also reduce susceptibility to aztreonam-avibactam. The combination of these two mechanisms leads to full resistance.
Genomic Characterization of Salmonella Minnesota Clonal Lineages Associated with Poultry Production in Brazil.
The study identified multiple antimicrobial resistance genes, including aac(6')-Iaa, mdf(A), sul2, tet(A), blaCMY-2, aph(3')-Ia_1, qnrB19, and ant(3'')-Ia, in Salmonella Minnesota isolates from Brazilian poultry farms, indicating widespread resistance to various antibiotics.
Snapshot Study of Whole Genome Sequences of Escherichia coli from Healthy Companion Animals, Livestock, Wildlife, Humans and Food in Italy.
The study identified multiple antimicrobial resistance genes (ARGs) and mutations in Escherichia coli isolates from various sources in Italy, highlighting the prevalence of resistance to tetracycline, sulfonamide, penicillin, fluoroquinolone, and colistin. Key genes included tetA, sul2, blaTEM-1b, mcr-1, qnrS1, and others, along with mutations in gyrA, parC, parE, and pmrB.
Genomic Analysis of SXT/R391 Integrative Conjugative Elements From Proteus mirabilis Isolated in Brazil.
The study identified SXT/R391 integrative conjugative elements (ICEs) in Proteus mirabilis isolates from Brazil, including the globally prevalent ICE Pmi Jpn1 carrying the CMY-2 beta-lactamase gene, which confers resistance to various beta-lactam antibiotics.
Genomic Analysis of SXT/R391 Integrative Conjugative Elements From Proteus mirabilis Isolated in Brazil.
The study identified SXT/R391 integrative conjugative elements (ICEs) in Proteus mirabilis isolates from Brazil, including the globally prevalent ICE Pmi Jpn1 carrying the CMY-2 beta-lactamase gene, which confers resistance to various beta-lactam antibiotics.
The importance of using whole genome sequencing and extended spectrum beta-lactamase selective media when monitoring antimicrobial resistance.
The study highlights the utility of whole genome sequencing (WGS) in monitoring antimicrobial resistance (AMR) trends, particularly in identifying ESBL genes such as bla CTX-M-1, bla CTX-M-15, bla SHV-12, bla CMY-2, and bla DHA-1, along with other resistance genes like sul2, tet(A), dfrA17, aadA5, ant3-1a, strA, strB, and fosA3 in E. coli isolates from pig surveillance.
Aeromonas hydrophila RIT668 and Citrobacter portucalensis RIT669-Potential Zoonotic Pathogens Isolated from Spotted Turtles.
Aeromonas hydrophila RIT668 and Citrobacter portucalensis RIT669 were found to be resistant to several antibiotics including gentamicin, tetracycline, doxycycline, kanamycin, streptomycin, tobramycin, novobiocin, and erythromycin, but susceptible to neomycin and cotrimoxazole. They exhibited multidrug resistance in the planktonic phase and weak biofilm eradication even with neomycin and cotrimoxazole.
Plasmid-Mediated Ampicillin, Quinolone, and Heavy Metal Co-Resistance among ESBL-Producing Isolates from the Yamuna River, New Delhi, India.
The study identified plasmid-mediated resistance genes bla CMY-2, bla CMY-42, qnrS, merB, merP, merT, and arsC in ESBL-producing isolates from the Yamuna River, indicating co-resistance to antibiotics and heavy metals.
Plasmid-Mediated Ampicillin, Quinolone, and Heavy Metal Co-Resistance among ESBL-Producing Isolates from the Yamuna River, New Delhi, India.
The study identified plasmid-mediated resistance genes bla CMY-2, bla CMY-42, qnrS, merB, merP, merT, and arsC in ESBL-producing isolates from the Yamuna River, indicating co-resistance to antibiotics and heavy metals.
The Novel CarbaLux Test for Carbapenemases and Carbapenem Deactivating AmpC Beta-Lactamases.
The CarbaLux test was developed to rapidly detect carbapenemase-producing bacteria, including various OXA-type carbapenemases (OXA-23, OXA-24/40, OXA-48, OXA-181) and other carbapenemases (KPC, NDM, VIM, IMP-1, OXA-58). It also detects hyper-produced AmpC beta-lactamases, which deactivate carbapenems but are not detectable by previous rapid phenotypic assays.
Antibiotic Resistance and Virulence of Extraintestinal Pathogenic Escherichia coli (ExPEC) Vary According to Molecular Types.
The study identifies several antibiotic resistance genes (ARGs) and virulence factors (VFs) in extraintestinal pathogenic Escherichia coli (ExPEC) strains, highlighting their association with molecular types and resistance profiles.
Transferable Resistance to Highest Priority Critically Important Antibiotics for Human Health in Escherichia coli Strains Obtained From Livestock Feces in Uruguay.
The study identified multiple AMR genes in E. coli isolates from livestock in Uruguay, including qnrB19, qnrS1, qnrE1, bla CTX-M-8, bla CTX-M-2, bla CTX-M-15, bla CTX-M-14, bla CTX-M-55, bla CMY-2, bla SHV-12, and mcr-1, highlighting the presence of transferable resistance to critically important antibiotics.
Identifying novel beta-lactamase substrate activity through in silico prediction of antimicrobial resistance.
The study identified and experimentally validated 22 previously unknown beta-lactamase substrate activities, including novel resistance mechanisms conferred by genes such as blaCMY-2, blaCTX-M-15, blaCTX-M-3, blaCTX-M-27, blaTEM-1, blaTEM-30, and blaOXA-1.
Bacteria Broadly-Resistant to Last Resort Antibiotics Detected in Commercial Chicken Farms.
The study identified bla CMY, encoding the Class C beta-lactamase AmpC, in E. coli and Acinetobacter isolates from commercial chicken farms, contributing to resistance against cephalosporins.
Antimicrobial Resistance in Escherichia coli Strains Isolated from Humans and Pet Animals.
The study identifies several AMR genes in E. coli strains isolated from humans and pet animals, including blaTEM, qnrS1, qnrB1, blaCMY-2, blaCMY-59, tetA, tetB, sul1, sul2, and sul3, which confer resistance to various antibiotics such as beta-lactams, quinolones, tetracyclines, and sulfonamides.
Antimicrobial Resistance in Escherichia coli Strains Isolated from Humans and Pet Animals.
The study identifies several AMR genes in E. coli strains isolated from humans and pet animals, including blaTEM, qnrS1, qnrB1, blaCMY-2, blaCMY-59, tetA, tetB, sul1, sul2, and sul3, which confer resistance to various antibiotics such as beta-lactams, quinolones, tetracyclines, and sulfonamides.
The Effect of Antimicrobial Resistance Plasmids Carrying bla(CMY-2) on Biofilm Formation by Escherichia coli from the Broiler Production Chain.
The study shows that acquisition of bla(CMY-2)-carrying plasmids by quinolone-resistant E. coli (QREC) reduces their biofilm-forming abilities in microtiter plates, likely due to effects on flagellar function or expression.
Antibiotic resistance plasmid composition and architecture in Escherichia coli isolates from meat.
The study characterizes various AMR genes in plasmids from meat-derived E. coli isolates, highlighting the diversity and clustering of resistance genes such as bla CTX-M-1, aadA5, sul2, and others, along with their association with specific plasmid incompatibility groups.
Higher prevalence of multidrug-resistant extended-spectrum beta-lactamases producing Escherichia coli in unorganized pig farms compared to organized pig farms in Mizoram, India.
The study identified several AMR genes, including bla TEM, bla CTX-M, bla CMY, tetA, tetB, sul1, sul2, aadA, and dfrIa, in multidrug-resistant E. coli isolates from both organized and unorganized pig farms in Mizoram, India.
A Preliminary Study: Antibiotic Resistance of Escherichia coli and Staphylococcus aureus from the Meat and Feces of Various South African Wildlife Species.
The study identified antibiotic resistance genes in Escherichia coli and Staphylococcus aureus from wildlife meat and feces, including blaCMY, aadA, sul1, sul2, tetA, tetB, tetK, tetL, tetM, vanA, vanB, and blaZ, which conferred resistance to ampicillin, streptomycin, sulfonamides, tetracycline, vancomycin, and penicillin.
Resistance determinants and their genetic context in enterobacteria from a longitudinal study of pigs reared under various husbandry conditions.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, and bla CMY-2, which confer resistance to various beta-lactam antibiotics in enterobacteria from pigs. Additionally, bla IMP-7 was found to confer resistance to carbapenems in Providencia rettgeri.
Whole-genome analyses of extended-spectrum or AmpC β-lactamase-producing Escherichia coli isolates from companion dogs in Japan.
The study identified various beta-lactamase genes including bla CTX-M-27, bla CTX-M-15, bla CTX-M-14, and bla CMY-2 in ESBL/AmpC-producing E. coli isolates from companion dogs in Japan. Additionally, fluoroquinolone resistance was linked to mutations in gyrA, parC, and parE genes, while polymyxin resistance was associated with a mutation in pmrB.
High β-lactam resistance in Gram-negative bacteria associated with kennel cough and cat flu in Egypt.
The study identified various β-lactam resistance genes, including bla SHV, bla CTX-M, bla TEM, bla CMY, and bla ACT, as well as qnrS, which confer resistance to β-lactams and quinolones in Gram-negative bacteria associated with kennel cough and cat flu in Egypt.
Emergence of fosA3 and bla (CTX-M-) (14) in Multidrug-Resistant Citrobacter freundii Isolates From Flowers and the Retail Environment in China.
The study identifies fosA3 and bla CTX-M-14 in multidrug-resistant Citrobacter freundii isolates from flowers and retail environments in China, highlighting the role of untypable plasmids in the spread of these resistance genes.
Emergence of fosA3 and bla (CTX-M-) (14) in Multidrug-Resistant Citrobacter freundii Isolates From Flowers and the Retail Environment in China.
The study identifies fosA3 and bla CTX-M-14 in multidrug-resistant Citrobacter freundii isolates from flowers and retail environments in China, highlighting the role of untypable plasmids in the spread of these resistance genes.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Poultry and Wild Birds as a Reservoir of CMY-2 Producing Escherichia coli: The First Large-Scale Study in Greece.
The study identified bla CMY-2 as the sole plasmid-encoded AmpC β-lactamase gene in E. coli isolates from poultry and wild birds in Greece, along with mutations in gyrA and parC contributing to quinolone resistance.
Detection of Cephalosporin and Fluoroquinolone Resistance Genes via Novel Multiplex qPCR in Fecal Salmonella Isolates From Northern Californian Dairy Cattle, 2002-2016.
The study detected the presence of bla CMY–2 and bla TEM genes in Salmonella isolates from dairy cattle, indicating resistance to cephalosporins. No PMQR genes or bla CTX–M were found.
Detection of Cephalosporin and Fluoroquinolone Resistance Genes via Novel Multiplex qPCR in Fecal Salmonella Isolates From Northern Californian Dairy Cattle, 2002-2016.
The study detected the presence of bla CMY–2 and bla TEM genes in Salmonella isolates from dairy cattle, indicating resistance to cephalosporins. No PMQR genes or bla CTX–M were found.
Wild Boars Carry Extended-Spectrum β-Lactamase- and AmpC-Producing Escherichia coli.
Wild boars in Germany carry ESBL/AmpC-producing E. coli, with bla CTX-M-1, bla SHV-12, and bla CMY-2 being the most common beta-lactamase genes. Additional resistance genes include sul1, sul2, sul3, dfrA1, dfrA5, dfrA14, dfrA17, tet(A), cmlA, floR, and qnrS.
High fecal carriage of bla(CTX-M), bla(CMY-2), and plasmid-mediated quinolone resistance genes among healthy Korean people in a metagenomic analysis.
The study found high fecal carriage of bla(CTX-M), bla(CMY-2), and plasmid-mediated quinolone resistance genes among healthy Korean individuals, highlighting the widespread presence of these resistance genes in the gut microbiome.
Characterization of antimicrobial-resistant Escherichia coli causing urinary tract infections in dogs: Passive surveillance in Saskatchewan, Canada 2014 to 2018.
The study identified several AMR genes in E. coli causing UTIs in dogs, including bla CMY-2, aac(6')-Ib-cr, and various CTX-M-type ESBLs. These genes conferred resistance to beta-lactams, cephalosporins, and fluoroquinolones.
Prevalence and antimicrobial resistance of Klebsiella species isolated from clinically ill companion animals.
The study identified several extended-spectrum cephalosporin (ESC) resistance genes, including blaCTX-M-15, blaCTX-M-3, blaCTX-M-65, blaDHA-1, blaCMY-2, blaSHV-1, blaSHV-11, blaSHV-28, and blaTEM-1, in Klebsiella pneumoniae and Klebsiella oxytoca strains isolated from clinically ill companion animals. These genes were associated with resistance to various beta-lactam antibiotics.
ESBL and AmpC beta-lactamase Encoding Genes in E. coli From Pig and Pig Farm Workers in Vietnam and Their Association With Mobile Genetic Elements.
The study identified several ESBL and AmpC beta-lactamase encoding genes, including bla CTX-M-55, bla CTX-M-27, bla CTX-M-65, bla CTX-M-15, bla CTX-M-14, bla CMY-2, bla DHA-1, and bla CMY-42, in E. coli isolates from pigs and pig farm workers in Vietnam. These genes were found to be primarily plasmid-mediated and associated with various mobile genetic elements.
ESBL and AmpC beta-lactamase Encoding Genes in E. coli From Pig and Pig Farm Workers in Vietnam and Their Association With Mobile Genetic Elements.
The study identified several ESBL and AmpC beta-lactamase encoding genes, including bla CTX-M-55, bla CTX-M-27, bla CTX-M-65, bla CTX-M-15, bla CTX-M-14, bla CMY-2, bla DHA-1, and bla CMY-42, in E. coli isolates from pigs and pig farm workers in Vietnam. These genes were found to be primarily plasmid-mediated and associated with various mobile genetic elements.
Genetic Characterization of AmpC and Extended-Spectrum Beta-Lactamase Phenotypes in Escherichia coli and Salmonella From Alberta Broiler Chickens.
The study identified bla CMY-2 and bla TEM genes in E. coli and Salmonella isolates from Alberta broiler chickens, contributing to beta-lactam resistance. Additionally, aadA, aadA1a, and aadA2 genes were found to confer resistance to streptomycin.
Population structure and uropathogenic potential of extended-spectrum cephalosporin-resistant Escherichia coli from retail chicken meat.
The study identified blaCMY-2 as the primary gene conferring extended-spectrum cephalosporin resistance in E. coli isolates from retail chicken meat, with additional resistance genes such as blaTEM-1B, sul1, sul2, aadA1, aac(3)-VIa, aph, tet(A), tet(B), dfrA1, and dfrA5 also present.
Genetic but No Phenotypic Associations between Biocide Tolerance and Antibiotic Resistance in Escherichia coli from German Broiler Fattening Farms.
The study identified various AMR genes in E. coli isolates from German broiler farms, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-1C, blaCTX-M-1, blaCMY-2), quinolone resistance genes (qnrB19, qnrS1), chloramphenicol resistance gene (cat1), tetracycline resistance genes (tetA, tetB), sulfonamide resistance genes (sul1, sul2), dihydrofolate reductase genes (drfA1, drfA5, drfA14, drfA17), aminoglycoside resistance gene (aadA1), and efflux pump genes (sugEp, qacEΔ1, mdfA).
Molecular Detection of Antibiotic Resistance Genes in Shiga Toxin-Producing E. coli Isolated from Different Sources.
The study identified multiple antibiotic resistance genes in Shiga toxin-producing E. coli (STEC) isolates, including aadA1, aac(3)-I, ere(A), ampC, blaSHV, blaCMY, and tet(A), which conferred resistance to various antibiotics such as streptomycin, gentamicin, erythromycin, ampicillin, penicillin, cephalosporin, and tetracycline.
Antimicrobial Resistance Genes and Diversity of Clones among ESBL- and Acquired AmpC-Producing Escherichia coli Isolated from Fecal Samples of Healthy and Sick Cats in Portugal.
The study identified various ESBL and qAmpC genes in E. coli isolates from cats, highlighting the presence of bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-27, bla CTX-M-9, bla TEM, bla SHV-28, and bla CMY-2, along with other resistance genes such as tet(A), tet(B), sul1, sul2, aac(6')-Ib-cr, and armA.
Antimicrobial Resistance Profile and ExPEC Virulence Potential in Commensal Escherichia coli of Multiple Sources.
The study identified several AMR genes, including blaCTX-M, mcr-1, and qnrS1, which confer resistance to cephalosporins, colistin, and fluoroquinolones, respectively, in commensal E. coli from various sources.
Genomic Diversity and Virulence Potential of ESBL- and AmpC-β-Lactamase-Producing Escherichia coli Strains From Healthy Food Animals Across Europe.
The study identifies various ESBL and AmpC beta-lactamase genes, including bla SHV-12, bla CTX-M-1, bla CTX-M-2, bla CTX-M-14, bla CTX-M-15, bla TEM-52, and bla CMY-2, along with the mcr-1 gene conferring colistin resistance in E. coli isolates from food animals in Europe.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2018/2019.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, including high resistance levels to ampicillin, tetracyclines, and fluoroquinolones in Salmonella and Campylobacter isolates. It also notes the emergence of resistance to third-generation cephalosporins and carbapenems, along with the detection of linezolid-resistant strains harboring the cfr gene in fattening pigs.
Metallo-β-lactamase and AmpC genes in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa isolates from abattoir and poultry origin in Nigeria.
The study identified the presence of metallo-beta-lactamase (blaIMP-1, blaIMP-2) and AmpC beta-lactamase (blaCMY, blaFOX) genes in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa isolates from abattoir and poultry origins in Nigeria, indicating the circulation of these resistance genes in the environment.
Antimicrobial Resistance Glides in the Sky-Free-Living Birds as a Reservoir of Resistant Escherichia coli With Zoonotic Potential.
The study identified multiple AMR genes and mutations in E. coli from free-living birds, highlighting the zoonotic potential of these resistant strains. Key findings include bla CTX-M-15, bla CMY-2, bla SHV-12, bla TEM-1B, qnrS1, qnrB19, mcr-1, fosA7, aac(3)-IIa, ant(3")-Ia, aph(3")-Ib, and aph(6)-Id, as well as mutations in gyrA, parC, and parE.
Combining Functional Genomics and Whole-Genome Sequencing to Detect Antibiotic Resistance Genes in Bacterial Strains Co-Occurring Simultaneously in a Brazilian Hospital.
The study identified multiple beta-lactamase genes, including blaTEM-105, blaOXA-1, blaKPC-2, blaCTX-M-15, blaCMY-111, blaOXA-10, blaCTX-M-1, blaHYDRO, and blaBLP, along with qnrS1, aadC, and ermC, which confer resistance to beta-lactam, quinolone, aminoglycoside, and macrolide/lincosamide/streptogramin B antibiotics. These genes were found in various bacterial species and were validated through functional screening.
Molecular Epidemiology of Extensively Drug-Resistant mcr Encoded Colistin-Resistant Bacterial Strains Co-Expressing Multifarious β-Lactamases.
The study identified mcr-1 and mcr-2 genes in colistin-resistant bacterial strains, along with various β-lactamase genes such as bla CTM-1, bla CTM-15, bla CMY-2, bla NDM-1, and bla NDM-5. These genes contribute to multidrug resistance in clinical isolates.
Frequency, Local Dynamics, and Genomic Characteristics of ESBL-Producing Escherichia coli Isolated From Specimens of Hospitalized Horses.
The study identified several ESBL genes, including blaCTX-M-1, blaCTX-M-15, blaSHV-12, blaOXA-1, blaCTX-M-14, blaCTX-M-3, and blaCMY-2, along with aminoglycoside resistance genes like aac(3)-IV, sulfonamide resistance genes sul1 and sul2, and trimethoprim resistance genes dfrA and dfrG, in ESBL-producing E. coli isolates from hospitalized horses.
Antibiotic resistance among Escherichia coli and Salmonella isolated from dairy cattle feces in Texas.
The study identified bla CMY-2 and tet(A) as significant AMR genes in E. coli isolates from dairy cattle feces, alongside specific mutations in gyrA, pmrB, mef(B), and aph(3')-Ia.
Emergence of transferable ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae due to a novel CMY AmpC beta-lactamase in China.
The study identifies a novel CMY AmpC beta-lactamase gene, blaCMY-172, which confers resistance to ceftazidime/avibactam in KPC-producing Klebsiella pneumoniae strains.
Emergence of transferable ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae due to a novel CMY AmpC β-lactamase in China.
Emergence of transferable ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae due to a novel CMY AmpC β-lactamase in China.
Are There Effective Intervention Measures in Broiler Production against the ESBL/AmpC Producer Escherichia coli?
The study identifies several beta-lactamase genes including blaCTX-M15, blaTEM-52, blaTEM-20, blaSHV-12, blaSHV-12/TEM, blaCTX-M1, and blaCMY-2 that confer resistance to various beta-lactam antibiotics in ESBL/AmpC-producing E. coli isolates from broiler chickens.
Escherichia coli Antibiotic Resistance Patterns from Co-Grazing and Non-Co-Grazing Livestock and Wildlife Species from Two Farms in the Western Cape, South Africa.
The study identified several antibiotic resistance genes in E. coli isolates from livestock and wildlife, including bla CMY, aad A1, sul 1, sul 2, tet A, and tet B, which conferred resistance to ampicillin, streptomycin, sulfonamides, and tetracycline. The research highlights differences in resistance patterns between co-grazing and non-co-grazing animals.
Diversity of Plasmids and Genes Encoding Resistance to Extended-Spectrum beta-lactamase in Escherichia coli from Different Animal Sources.
The study identified various AMR genes and mutations in E. coli isolates from different animal sources, highlighting the presence of ESBL genes such as bla CTX-M-15, bla TEM-1B, and bla CMY-28, as well as mutations in parC and gyrA that confer resistance to fluoroquinolones.
Diversity of Plasmids and Genes Encoding Resistance to Extended-Spectrum β-Lactamase in Escherichia coli from Different Animal Sources.
The study identified various AMR genes and mutations in E. coli isolates from different animal sources, highlighting the presence of ESBL genes such as bla CTX-M-15, bla TEM-1B, and bla CMY-28, as well as mutations in parC and gyrA that confer resistance to fluoroquinolones.
Molecular Characterization of Antimicrobial Resistance and Virulence Genes of Bacterial Pathogens from Bovine and Caprine Mastitis in Northern Lebanon.
The study identified several AMR genes, including blaTEM, blaCMY-II, blaOXA, and mecA, in bacterial pathogens causing mastitis in dairy animals in Northern Lebanon.
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
Detection of carbapenemase producing enterobacteria using an ion sensitive field effect transistor sensor.
The study evaluated the effectiveness of an ion-sensitive field-effect transistor (ISFET) sensor for detecting carbapenemase-producing enterobacteria. It successfully identified various carbapenemase genes including blaNDM-1, blaVIM-1, blaIMP-1, blaKPC-2, blaNMC-A, and blaOXA-48 in different bacterial strains.
Characterization of antibiotic resistance in Escherichia coli isolates from Black-headed gulls (Larus ridibundus) present in the city of Novi Sad, Serbia.
The study identified bla TEM-1, bla CTX-M-1, and bla CMY-2 genes in E. coli isolates from black-headed gulls, as well as mutations in gyrA and parC genes contributing to ciprofloxacin resistance.
Characterization of Extended-Spectrum Cephalosporin (ESC) Resistance in Salmonella Isolated from Chicken and Identification of High Frequency Transfer of bla(CMY-2) Gene Harboring Plasmid In Vitro and In Vivo.
The study identified the bla(CMY-2) gene as a major contributor to extended-spectrum cephalosporin resistance in Salmonella isolated from chickens. It demonstrated the high-frequency transfer of the bla(CMY-2)-harboring plasmid between Salmonella and pathogenic E. coli in both in vitro and in vivo settings, highlighting the potential risk of antimicrobial resistance dissemination through the food chain.
First Detection of Human ST131-CTX-M-15-O25-B2 Clone and High-Risk Clonal Lineages of ESBL/pAmpC-Producing E. coli Isolates from Diarrheic Poultry in Tunisia.
The study identified the presence of the human pandemic ST131-CTX-M-15-O25-B2 clone and high-risk clonal lineages of ESBL/pAmpC-producing E. coli isolates from diarrheic poultry in Tunisia, highlighting the emergence of multidrug-resistant clones with various virulence determinants.
Antimicrobial Resistance Profiling of Biofilm Forming Non Typhoidal Salmonella enterica Isolates from Poultry and Its Associated Food Products from Pakistan.
The study identified several AMR genes in Salmonella enterica isolates from poultry and food products in Pakistan, including bla TEM-1, bla OxA-1, bla PSE-1, bla CMY-2, ampC, and the virulence gene sopE. These genes were associated with resistance to multiple antibiotics, highlighting the public health concerns related to AMR in Salmonella.
The Beta-Lactam Resistome Expressed by Aerobic and Anaerobic Bacteria Isolated from Human Feces of Healthy Donors.
The study identifies several beta-lactamase genes, including blaTEM, blaSHV, blaKPC, blaCMY, blaBIL, blaCFX, and blaP, in aerobic and anaerobic bacteria isolated from the feces of healthy donors, highlighting the human gut as a reservoir of beta-lactam resistance.
ESBL/AmpC-Producing Escherichia coli in Wild Boar: Epidemiology and Risk Factors.
The study identified bla CTX-M, bla TEM, bla CMY, and bla SHV genes in ESBL/AmpC-producing E. coli from wild boar, highlighting the role of wild boar as a potential reservoir of antimicrobial resistance.
Antimicrobial resistance patterns among different Escherichia coli isolates in the Kingdom of Saudi Arabia.
The study identified several beta-lactamase genes (blaCTX-M-1group, blaCTX-M-15, blaCTX-M-2group, blaOXA-47, blaTEM, blaCMY-2) and the quinolone resistance gene qnrS in E. coli isolates from various sources in Saudi Arabia. These genes contribute to resistance against multiple antibiotics, highlighting the need for improved antimicrobial stewardship.
Molecular Characterization and Survive Abilities of Salmonella Heidelberg Strains of Poultry Origin in Brazil.
The study identified the presence of bla CTX-M and bla CMY-2 genes in Salmonella Heidelberg strains, which confer resistance to various beta-lactam antibiotics. These genes were detected in 80% of the strains, highlighting the prevalence of multidrug resistance in poultry-origin Salmonella Heidelberg.
WGS characterization of MDR Enterobacterales with different ceftolozane/tazobactam susceptibility profiles during the SUPERIOR surveillance study in Spain.
WGS characterization of MDR Enterobacterales with different ceftolozane/tazobactam susceptibility profiles during the SUPERIOR surveillance study in Spain.
WGS characterization of MDR Enterobacterales with different ceftolozane/tazobactam susceptibility profiles during the SUPERIOR surveillance study in Spain.
Molecular epidemiology of cefotaxime-resistant but ceftazidime-susceptible Enterobacterales and evaluation of the in vitro bactericidal activity of ceftazidime and cefepime.
The study identified bla CTX-M-2, bla CTX-M-14, and bla CMY-2 as the primary genes responsible for the dissociated resistance phenotype (DRP) in Enterobacterales, where isolates were resistant to cefotaxime (CTX) but susceptible to ceftazidime (CAZ).
Transmission of extended-spectrum cephalosporin-resistant Salmonella harboring a bla(CMY-2)-carrying IncA/C(2) plasmid chromosomally integrated by ISEcp1 or IS26 in layer breeding chains in Japan.
The study identified bla CMY-2 and bla CTX-M-14 genes in Salmonella strains from Japanese layer breeding chains, highlighting the role of IncA/C2 plasmids and insertion sequences in the dissemination of antimicrobial resistance.
Foodborne Pathogenic Vibrios: Antimicrobial Resistance.
The paper discusses the presence of various antibiotic resistance genes in Vibrio species, including strB, sul2, tetA, blaTEM, qnrA, ermB, floR, aac(3)-IIa, blaNDM-1, blaCMY, blaP1, catB3, and others, which confer resistance to antibiotics such as streptomycin, sulfamethoxazole, tetracycline, ampicillin, fluoroquinolones, erythromycin, florfenicol, gentamicin, carbapenems, chloramphenicol, and trimethoprim.
Detection of bla(TEM), bla(CTX-M), bla(CMY), and bla(SHV) Genes Among Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolated from Migratory Birds Travelling to Bangladesh.
The study identified bla(TEM), bla(CTX-M), bla(CMY), and bla(SHV) genes in extended-spectrum beta-lactamase-producing Escherichia coli isolated from migratory birds in Bangladesh, highlighting the role of migratory birds as potential carriers of antibiotic resistance genes.
Plasmid analysis of NDM metallo-β-lactamase-producing Enterobacterales isolated in Vietnam.
The study characterizes bla NDM-1 and bla NDM-4 carrying plasmids in Enterobacterales isolates from Vietnam, highlighting their role in carbapenem resistance and horizontal gene transfer.
Prevalence and mechanisms of antibiotic resistance in Escherichia coli isolated from mastitic dairy cattle in Canada.
The study identified several AMR genes in E. coli isolates from bovine mastitis, including beta-lactamases (blaTEM-1, blaCARB-3, blaCMY-59), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aadA2), and multidrug efflux pump genes (acrA, acrB, acrD, tolC, baeR, emrA, emrB).
Comparative genomics of Salmonella enterica subsp. diarizonae serovar 61:k:1,5,(7) reveals lineage-specific host adaptation of ST432.
The study identified a single antimicrobial resistance gene, blaCMY-2, in a ST432 isolate from a human clinical sample, which confers resistance to beta-lactam and third-generation cephaloporin antibiotics. The rest of the SASd isolates did not possess resistance genes.
Molecular Characterization of Cephalosporin and Fluoroquinolone Resistant Salmonella Choleraesuis Isolated from Patients with Systemic Salmonellosis in Thailand.
The study identified multiple ESBL genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla CMY-2, bla ACC-1, and bla TEM-1, along with PMQR genes such as qnrA, qnrB, qnrS, and aac(6′)-Ib-cr, contributing to resistance against cephalosporins and fluoroquinolones in Salmonella Choleraesuis isolates from Thailand.
High Prevalence of ESBL and Plasmid-Mediated Quinolone Resistance Genes in Salmonella enterica Isolated from Retail Meats and Slaughterhouses in Egypt.
The study identified various ESBL and PMQR genes in Salmonella enterica isolates from retail meats and slaughterhouses in Egypt, highlighting their high prevalence and potential public health implications.
High Prevalence of ESBL and Plasmid-Mediated Quinolone Resistance Genes in Salmonella enterica Isolated from Retail Meats and Slaughterhouses in Egypt.
The study identified various ESBL and PMQR genes in Salmonella enterica isolates from retail meats and slaughterhouses in Egypt, highlighting their high prevalence and potential public health implications.
Meropenem Versus Piperacillin-Tazobactam for Definitive Treatment of Bloodstream Infections Caused by AmpC β-Lactamase-Producing Enterobacter spp, Citrobacter freundii, Morganella morganii, Providencia spp, or Serratia marcescens: A Pilot Multicenter Randomized Controlled Trial (MERINO-2).
The study identified several AmpC β-lactamase genes, including bla CMY-2, bla CMY-101, bla CMY-51, bla ACT-17, bla ACT-12, bla ACT-15, bla ACT-16, bla ACT-2, bla ACT-27, bla ACT-38, bla ACT-40, bla ACT-43, bla ACT-49, bla ACT-55, bla CMH-3, bla CMH-1, bla DHA-17, bla DHA-20, bla DHA-12, bla DHA-16, bla DHA-18, bla MIR-18, bla MIR-19, and bla MIR-9, which confer resistance to piperacillin-tazobactam in various Enterobacterales species.
Meropenem Versus Piperacillin-Tazobactam for Definitive Treatment of Bloodstream Infections Caused by AmpC β-Lactamase-Producing Enterobacter spp, Citrobacter freundii, Morganella morganii, Providencia spp, or Serratia marcescens: A Pilot Multicenter Randomized Controlled Trial (MERINO-2).
The study identified several AmpC β-lactamase genes, including bla CMY-2, bla CMY-101, bla CMY-51, bla ACT-17, bla ACT-12, bla ACT-15, bla ACT-16, bla ACT-2, bla ACT-27, bla ACT-38, bla ACT-40, bla ACT-43, bla ACT-49, bla ACT-55, bla CMH-3, bla CMH-1, bla DHA-17, bla DHA-20, bla DHA-12, bla DHA-16, bla DHA-18, bla MIR-18, bla MIR-19, and bla MIR-9, which confer resistance to piperacillin-tazobactam in various Enterobacterales species.
Meropenem Versus Piperacillin-Tazobactam for Definitive Treatment of Bloodstream Infections Caused by AmpC β-Lactamase-Producing Enterobacter spp, Citrobacter freundii, Morganella morganii, Providencia spp, or Serratia marcescens: A Pilot Multicenter Randomized Controlled Trial (MERINO-2).
The study identified several AmpC β-lactamase genes, including bla CMY-2, bla CMY-101, bla CMY-51, bla ACT-17, bla ACT-12, bla ACT-15, bla ACT-16, bla ACT-2, bla ACT-27, bla ACT-38, bla ACT-40, bla ACT-43, bla ACT-49, bla ACT-55, bla CMH-3, bla CMH-1, bla DHA-17, bla DHA-20, bla DHA-12, bla DHA-16, bla DHA-18, bla MIR-18, bla MIR-19, and bla MIR-9, which confer resistance to piperacillin-tazobactam in various Enterobacterales species.
Antibiotic-resistant bacteria, antibiotic resistance genes, and antibiotic residues in wastewater from a poultry slaughterhouse after conventional and advanced treatments.
The study identified several antibiotic resistance genes (ARGs) in wastewater from a poultry slaughterhouse, including bla TEM, bla CTX-M-1, bla SHV-12, mcr-1, ermB, sul1, tetM, bla OXA-48, bla CMY-2, and vanA. These genes were found to confer resistance to various antibiotics such as beta-lactams, macrolides, sulfonamides, tetracyclines, carbapenems, and glycopeptides.
Genomic Insights into Drug Resistance Determinants in Cedecea neteri, A Rare Opportunistic Pathogen.
The study identifies multiple beta-lactamase genes, including a novel CMY/ACT-type AmpC beta-lactamase and several metallo-beta-lactamases, as well as multidrug efflux pumps in Cedecea neteri, highlighting its resistance mechanisms against various antibiotics.
Genetic Features of Plasmid- and Chromosome-Mediated mcr-1 in Escherichia coli Isolates From Animal Organs With Lesions.
The study characterizes the mcr-1 gene and various other resistance genes in Escherichia coli isolates from animal organs with lesions, highlighting their multidrug resistance profiles and the genetic features of plasmids carrying these genes.
Discerning the Antimicrobial Resistance, Virulence, and Phylogenetic Relatedness of Salmonella Isolates Across the Human, Poultry, and Food Materials Sources in Malaysia.
The study identified several AMR genes in Salmonella Enteritidis isolates from Malaysia, including aac(6')-ly, blaCMY-2, blaTEM-1, blaTEM-33, blaTEM-4, dfrA14, dfrA15, floR, qnrS1, qnrD1, sul1, sul2, strA, strB, tetA, and tetC. These genes conferred resistance to various antibiotics such as gentamicin, ampicillin, chloramphenicol, ciprofloxacin, sulfamethazine/trimethoprim, and tetracycline.
Occurrence of Colibacillosis in Broilers and Its Relationship With Avian Pathogenic Escherichia coli (APEC) Population Structure and Molecular Characteristics.
The study identified multiple antimicrobial resistance genes in Avian Pathogenic Escherichia coli (APEC) isolates, including beta-lactamases (blaCMY-2, blaSHV-12, blaTEM-52, blaCTX-M-1), aminoglycoside resistance genes (aac(3)-IV, aadA, strA, strB, aph(3')-Ib), sulfonamide resistance gene (sul1), tetracycline resistance genes (tet(A), tet(B)), trimethoprim resistance gene (dfrA), quinolone resistance genes (qnrS1, qnrS2, qnrB19), macrolide resistance genes (mph(A), mph(B)), and chloramphenicol resistance gene (catA1).
Extended-Spectrum β-Lactam Resistant Klebsiella pneumoniain and Escherichia coli in Wild European Hedgehogs (Erinaceus europeus) Living in Populated Areas.
The study identified several β-lactamase resistance genes, including bla CTX-M-15, bla SHV-28, bla CMY-1, bla CMY-2, and bla OXA-48, in extended-spectrum β-lactam-resistant Klebsiella pneumoniae and Escherichia coli isolated from wild European hedgehogs in Catalonia, Spain.
Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms.
The study identified several ESBL genes, colistin resistance genes, and other AMR genes in ESBL-producing E. coli from pigs and pig farm workers in Vietnam. Key findings include the prevalence of bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27, along with mcr-1 and mcr-3 for colistin resistance, and various other resistance genes for aminoglycosides, quinolones, tetracyclines, chloramphenicol, macrolides, and sulfonamides.
Extended-Spectrum-β-Lactamase- and AmpC-Producing Escherichia coli in Domestic Dogs: Spread, Characterisation and Associated Risk Factors.
The study identified bla CTX-M, bla TEM, bla CMY, and bla SHV as the primary AMR genes in ESBL/AmpC-producing E. coli from domestic dogs, with bla CTX-M being the most prevalent. These genes were associated with resistance to various cephalosporins and other beta-lactam antibiotics.
Identification of Three Novel PmGRI1 Genomic Resistance Islands and One Multidrug Resistant Hybrid Structure of Tn7-like Transposon and PmGRI1 in Proteus mirabilis.
The study identifies three novel variants of PmGRI1 and a hybrid structure combining Tn7-like transposon and PmGRI1 in Proteus mirabilis, highlighting their role in carrying multiple antibiotic resistance genes.
Third generation cephalosporin resistance in clinical non-typhoidal Salmonella enterica in Germany and emergence of bla(CTX-M)-harbouring pESI plasmids.
The study identifies bla CTX-M-1, bla CTX-M-14, and bla CTX-M-65 as the most prevalent ESBL genes responsible for third-generation cephalosporin resistance in clinical non-typhoidal Salmonella enterica isolates in Germany. It also highlights the emergence of pESI plasmids carrying bla CTX-M-65 and bla CTX-M-1.
Multidrug Resistance Dynamics in Salmonella in Food Animals in the United States: An Analysis of Genomes from Public Databases.
The study analyzed 22,102 Salmonella genomes from public databases to track antimicrobial resistance (AMR) trends in food animals in the United States. It found that the prevalence of multidrug resistance (MDR) decreased in bovines and swine but increased in poultry. Key AMR genes identified include bla CMY-2, bla CTX-M-65, floR, tetA, sul2, aadA2, aac(3)-VIa, qnrB19, qnrB2, bla SHV-12, bla TEM-1, bla CARB-2, aph(3")-Ib, aph(6)-Id, aph(3')-Ia, ant(3")-Ia, aph(4)-Ia, and aac(3)-IVa. A significant mutation, gyrA D87Y, was associated with quinolone resistance in poultry.
Imported One-Day-Old Chicks as Trojan Horses for Multidrug-Resistant Priority Pathogens Harboring mcr-9, rmtG, and Extended-Spectrum β-Lactamase Genes.
The study identified multidrug-resistant pathogens in imported 1-day-old chicks harboring mcr-9, rmtG, and extended-spectrum β-lactamase genes, highlighting the role of these chicks as vectors for the spread of antimicrobial resistance.
Monitoring the Microevolution of Salmonella enterica in Healthy Dairy Cattle Populations at the Individual Farm Level Using Whole-Genome Sequencing.
The study identified several AMR genes, including bla CMY-2, floR, sul2, and tetA, in Salmonella enterica isolates from dairy cattle. These genes confer resistance to various antibiotics such as cephalosporins, florfenicol, sulfamethoxazole-trimethoprim, and tetracycline.
Genetic evaluation of ESBL-producing Escherichia coli urinary isolates in Otago, New Zealand.
The study identified various ESBL genes, including bla CTX-M, bla TEM, bla SHV, and bla OXA, in ESBL-producing E. coli isolates from Otago, New Zealand. The most prevalent ESBL gene was bla CTX-M, with several subtypes such as CTX-M-14, CTX-M-15, CTX-M-27, and CTX-M-55. Additionally, other beta-lactamase genes like bla CMY-2 were also detected. The study highlights the genetic diversity of ESBL-Ec isolates and the presence of multiple resistance mechanisms.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
The study identified various CTX-M-type beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, bla CTX-M-55, and bla CTX-M-65, as well as other beta-lactamase genes such as bla TEM-1, bla CARB-2, and bla CMY-2 in ESBL E. coli isolates from sheep and their abattoir environment. Additional AMR genes related to aminoglycosides, macrolides, phenicols, quinolones, sulfonamides, tetracyclines, and trimethoprim were also detected.
Genomic Comparison of Conjugative Plasmids from Salmonella enterica and Escherichia coli Encoding Beta-Lactamases and Capable of Mobilizing Kanamycin Resistance Col-like Plasmids.
The study identifies blaCMY-2 as a beta-lactamase gene encoded on conjugative plasmids in Salmonella enterica and Escherichia coli, which confers resistance to multiple beta-lactam antibiotics.
A pentaplex real-time PCR assay for rapid identification of major beta-lactamase genes KPC, NDM, CTX, CMY, and OXA-48 directly from bacteria in blood.
The study presents a pentaplex real-time PCR assay for the rapid identification of major beta-lactamase genes KPC, NDM, CTX, CMY, and OXA-48 directly from bacteria in blood.
Prevalence and Characteristics of Ceftriaxone-Resistant Salmonella in Children's Hospital in Hangzhou, China.
The study identified various beta-lactamase genes, including bla CTX-M-55, bla CTX-M-65, bla CTX-M-14, bla CTX-M-9, bla CTX-M-64, bla CTX-M-130, bla CMY-2, bla TEM-1, bla TEM-215, bla OXA-1, bla OXA-10, and bla LAP-2, as the primary resistance mechanisms for ceftriaxone-resistant Salmonella. Additionally, the mcr-1 gene was found to confer resistance to colistin.
Mobility of β-lactam resistance under ampicillin treatment in gut microbiota suffering from pre-disturbance.
The study demonstrates the mobility of the blaCMY-2 gene under ampicillin treatment in gut microbiota, highlighting the impact of pre-existing gut dysbiosis on the dissemination and persistence of β-lactam resistance.
Genomic diversity of antimicrobial resistance in non-typhoidal Salmonella in Victoria, Australia.
The study identified various AMR genes and mutations in non-typhoidal Salmonella, including bla TEM-1, bla TEM-135, strAB, sul1, sul2, tet(A), tet(B), floR, bla CMY-2, bla CTX-M-55, and bla CTX-M-65, along with mutations in gyrA and parC contributing to ciprofloxacin resistance.
Antimicrobial Resistance in Salmonella Isolated from Food Workers and Chicken Products in Japan.
The study identified several beta-lactamase genes, including bla CMY-2, bla CTX-M-15, bla CTX-M-55, bla TEM-52B, bla LAT-3, bla LAP-2, and bla TEM-1, which were associated with cefotaxime resistance in Salmonella isolates from food workers and chicken products in Japan.
Outbreak of Multidrug-Resistant Salmonella Heidelberg Infections Linked to Dairy Calf Exposure, United States, 2015-2018.
The study identifies a multidrug-resistant (MDR) Salmonella Heidelberg outbreak linked to dairy calf exposure, highlighting the presence of plasmid-borne resistance genes such as aadA1, aph(3')-Ia, bla CMY-2, floR, fosA7, qnrB19, strA, strB, sull, sul2, tet(A), tet(B), tet(O), and a novel gene dfrA34.
Impact of Carbapenem Heteroresistance Among Multidrug-Resistant ESBL/AmpC-Producing Klebsiella pneumoniae Clinical Isolates on Antibiotic Treatment in Experimentally Infected Mice.
Three IPM-heteroresistant strains of MDR ESBL/AmpC-producing K. pneumoniae were identified, which exhibited reduced expression of ompK36 and failed IPM therapy in a mouse model of peritonitis.
Resistance Patterns, mcr-4 and OXA-48 Genes, and Virulence Factors of Escherichia coli from Apennine Chamois Living in Sympatry with Domestic Species, Italy.
The study identified the colistin resistance gene mcr-4 and carbapenems resistance gene OXA-48 in Escherichia coli isolates from wild and domestic ungulates in Italy, highlighting the presence of these resistance mechanisms in wildlife.
Colistin Resistance in Monophasic Isolates of Salmonella enterica ST34 Collected From Meat-Derived Products in Spain, With or Without CMY-2 Co-production.
The study identifies the mcr-1.1 gene on IncX4 and IncHI2 plasmids as the primary determinant of colistin resistance in Salmonella enterica ST34 isolates from meat products in Spain. Additionally, the bla CMY-2 gene on an IncI1-I(α) plasmid was found to confer resistance to cefotaxime and cefoxitin.
Plasmid-mediated colistin resistance and ESBL production in Escherichia coli from clinically healthy and sick pigs.
The study identified mcr-3, bla CTX-M-14, bla CTX-M-55, bla TEM-1, and bla CMY-2 as key AMR genes in E. coli isolates from pigs in Thailand. Additionally, several mutations in PmrA and PmrB were associated with colistin resistance.
Flomoxef and fosfomycin in combination for the treatment of neonatal sepsis in the setting of highly prevalent antimicrobial resistance.
The study evaluated the combination of flomoxef and fosfomycin for treating neonatal sepsis in settings with high antimicrobial resistance. It found that the combination showed synergy in bacterial killing and prevented the emergence of fosfomycin resistance. Specific AMR genes and mutations were identified in Enterobacterales strains, including beta-lactamases and efflux pumps.
Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial.
Early-life broad-spectrum antibiotics alter the infant gut microbiome and resistome, with amoxicillin + cefotaxime having the most significant impact on AMR gene profiles.
First identification of bla (NDM-5) producing Escherichia coli from neonates and a HIV infected adult in Tanzania.
The study identifies bla NDM-5 producing Escherichia coli in Tanzania, highlighting the presence of carbapenem resistance and other resistance genes on various plasmids.
Liquid Chromatography-Tandem Mass Spectrometry Analysis Demonstrates a Decrease in Porins and Increase in CMY-2 beta-lactamases in Escherichia coli Exposed to Increasing Concentrations of Meropenem.
The study identified that mutations in the ompC gene leading to premature stop codons and gene interruptions contributed to meropenem resistance in E. coli. Additionally, an increase in CMY-2 beta-lactamase production was observed in resistant mutants.
Gut Commensal Escherichia coli, a High-Risk Reservoir of Transferable Plasmid-Mediated Antimicrobial Resistance Traits.
The study identified multiple plasmid-mediated antimicrobial resistance genes in gut commensal Escherichia coli isolates from healthy individuals, highlighting the potential risk of these bacteria as reservoirs of resistance traits.
Genomics of human and chicken Salmonella isolates in Senegal: Broilers as a source of antimicrobial resistance and potentially invasive nontyphoidal salmonellosis infections.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella isolates from Senegal, highlighting the prevalence of resistance to fluoroquinolones, sulfamethoxazole-trimethoprim, tetracycline, and erythromycin. Key genes included aac(3)-Id, aadA7, blaTEM-1b, blaDHA-1, blaOXA-10, blaCMY-2, dfrA1, dfrA14, floR, fosA, qnrB19, qnrB7, sul2, tetA, tetB, aph(3')-Ib, aph(3")-Ib, and aph(6)-Id. Mutations in parC and gyrA were also associated with fluoroquinolone resistance.
Pathogenic E. coli from Cattle as a Reservoir of Resistance Genes to Various Groups of Antibiotics.
The study identified various AMR genes in pathogenic E. coli strains from cattle in Romania and France, highlighting the presence of multidrug-resistant (MDR) strains and the diversity of resistance mechanisms.
Invited Review: Antimicrobial Use and Antimicrobial Resistance in Pathogens Associated with Diarrhea and Pneumonia in Dairy Calves.
The review identified several AMR genes in pathogens associated with calf diarrhea and pneumonia, including beta-lactamases (blaCMY, blaCTX-M, blaTEM), tetracycline resistance genes (tetA, tetB, tetM, tetO), aminoglycoside resistance genes (strA, strB, aadA), sulfonamide resistance genes (sul1, sul2), phenicol resistance genes (cat, floR), and macrolide/lincosamide resistance genes (cfr, ermB).
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
The study identified multiple AMR genes in multidrug-resistant E. coli and K. pneumoniae isolates from Kuwait, including beta-lactamases (blaKPC-2, blaCTX-M-15, blaOXA-1, blaCMY-4, blaTEM), aminoglycoside-modifying enzymes (aac(3)-IIa, aph(6)-Id, aadA5), sulfonamide resistance genes (sul1, sul2), quinolone resistance genes (gyrA_D87N, qnrB1), and others. Colistin resistance was linked to the pmrB_R256G mutation.
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
The study identified multiple AMR genes in multidrug-resistant E. coli and K. pneumoniae isolates from Kuwait, including beta-lactamases (blaKPC-2, blaCTX-M-15, blaOXA-1, blaCMY-4, blaTEM), aminoglycoside-modifying enzymes (aac(3)-IIa, aph(6)-Id, aadA5), sulfonamide resistance genes (sul1, sul2), quinolone resistance genes (gyrA_D87N, qnrB1), and others. Colistin resistance was linked to the pmrB_R256G mutation.
Characterization of Uropathogenic Escherichia coli Reveals Hybrid Isolates of Uropathogenic and Diarrheagenic (UPEC/DEC) E. coli.
The study identified ESBL-producing UPEC isolates carrying bla CTX-M-15-group, bla CTX-M-8-group, and bla CMY-2 genes, along with bla TEM-1, contributing to resistance against various beta-lactam antibiotics.
Inter-species geographic signatures for tracing horizontal gene transfer and long-term persistence of carbapenem resistance.
The study characterizes various carbapenem resistance genes such as blaKPC, blaNDM, blaOXA-48, blaVIM, blaIMP, blaGES, blaSIM, blaTEM, blaSHV, blaCTX-M, ampC, mecA, vanA, vanB, vanC, mcr-1, mcr-2, mcr-3, mcr-4, and mcr-5 in Enterobacterales and other bacterial species, highlighting their role in carbapenem resistance and horizontal gene transfer.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2019-2020.
The report highlights the presence of various antimicrobial resistance genes such as blaVIM-1, blaTEM-1B, blaTEM-1C, and cfr in different bacterial isolates, indicating resistance to carbapenems, beta-lactams, and macrolides/lincosamides/streptogramin B.
Convergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves.
The study identified various CTX-M-type and CMY-type beta-lactamase genes in multidrug-resistant Enterobacterales isolated from marine bivalves, highlighting the presence of resistance and virulence genes in marine environments.
Class C beta-lactamases: Molecular Characteristics.
The paper characterizes various class C beta-lactamases, highlighting their molecular characteristics, resistance profiles, and genetic variations. Key findings include the identification of specific genes such as blaACC-1, blaACT-1, blaADC-1, blaCMY-2, blaFOX-1, blaMOX-1, and blaPDC-1, along with their roles in conferring resistance to various β-lactam antibiotics.
Class C beta-lactamases: Molecular Characteristics.
The paper characterizes various class C beta-lactamases, highlighting their molecular characteristics, resistance profiles, and genetic variations. Key findings include the identification of specific genes such as blaACC-1, blaACT-1, blaADC-1, blaCMY-2, blaFOX-1, blaMOX-1, and blaPDC-1, along with their roles in conferring resistance to various β-lactam antibiotics.
Class C beta-lactamases: Molecular Characteristics.
The paper characterizes various class C beta-lactamases, highlighting their molecular characteristics, resistance profiles, and genetic variations. Key findings include the identification of specific genes such as blaACC-1, blaACT-1, blaADC-1, blaCMY-2, blaFOX-1, blaMOX-1, and blaPDC-1, along with their roles in conferring resistance to various β-lactam antibiotics.
Class C β-Lactamases: Molecular Characteristics.
The paper characterizes various class C β-lactamases, highlighting their molecular characteristics, resistance profiles, and genetic variations. Key findings include the identification of specific genes such as blaACC-1, blaACT-1, blaADC-1, blaCMY-2, blaFOX-1, blaMOX-1, and blaPDC-1, along with their roles in conferring resistance to various β-lactam antibiotics.
Class C β-Lactamases: Molecular Characteristics.
The paper characterizes various class C β-lactamases, highlighting their molecular characteristics, resistance profiles, and genetic variations. Key findings include the identification of specific genes such as blaACC-1, blaACT-1, blaADC-1, blaCMY-2, blaFOX-1, blaMOX-1, and blaPDC-1, along with their roles in conferring resistance to various β-lactam antibiotics.
Class C β-Lactamases: Molecular Characteristics.
The paper characterizes various class C β-lactamases, highlighting their molecular characteristics, resistance profiles, and genetic variations. Key findings include the identification of specific genes such as blaACC-1, blaACT-1, blaADC-1, blaCMY-2, blaFOX-1, blaMOX-1, and blaPDC-1, along with their roles in conferring resistance to various β-lactam antibiotics.
Class C β-Lactamases: Molecular Characteristics.
The paper characterizes various class C β-lactamases, highlighting their molecular characteristics, resistance profiles, and genetic variations. Key findings include the identification of specific genes such as blaACC-1, blaACT-1, blaADC-1, blaCMY-2, blaFOX-1, blaMOX-1, and blaPDC-1, along with their roles in conferring resistance to various β-lactam antibiotics.
Class C β-Lactamases: Molecular Characteristics.
The paper characterizes various class C β-lactamases, highlighting their molecular characteristics, resistance profiles, and genetic variations. Key findings include the identification of specific genes such as blaACC-1, blaACT-1, blaADC-1, blaCMY-2, blaFOX-1, blaMOX-1, and blaPDC-1, along with their roles in conferring resistance to various β-lactam antibiotics.
Class C β-Lactamases: Molecular Characteristics.
The paper characterizes various class C β-lactamases, highlighting their molecular characteristics, resistance profiles, and genetic variations. Key findings include the identification of specific genes such as blaACC-1, blaACT-1, blaADC-1, blaCMY-2, blaFOX-1, blaMOX-1, and blaPDC-1, along with their roles in conferring resistance to various β-lactam antibiotics.
Prevalence and Molecular Typing of Carbapenemase-Producing Enterobacterales among Newborn Patients in Italy.
The study identified various carbapenemase genes, including bla NDM, bla KPC, bla VIM, and bla OXA-48, along with other resistance genes such as aac(6')-Ib3, aph(3')-VI, rmtC, bla CMY-6, and bla CTX-M-15, in carbapenemase-producing Enterobacterales isolated from newborn patients in Italy.
Antimicrobial resistance in Escherichia coli isolated from on-farm and conventional hatching broiler farms in Ireland.
The study identified bla TEM-1 and bla CMY-2 as the primary beta-lactamase genes responsible for cefotaxime resistance in E. coli isolates from both on-farm and conventional hatching systems in Ireland.
Bacterial diversity and the antimicrobial resistome in the southwestern highlands of Saudi Arabia.
The study identified 102 antimicrobial resistance genes (ARGs) in the soil microbiota of the southwestern highlands of Saudi Arabia, primarily associated with multidrug resistance, macrolide, tetracycline, glycopeptide, bacitracin, and beta-lactam antibiotic resistance. qPCR confirmed the detection of 18 clinically important ARGs.
Analysis of Salmonella enterica Isolated from a Mixed-Use Watershed in Georgia, USA: Antimicrobial Resistance, Serotype Diversity, and Genetic Relatedness to Human Isolates.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from a mixed-use watershed in Georgia, USA, including bla CMY-2, aadA2, strA, strB, sul1, sul2, tetA, tetC, floR, and dfrA12, which conferred resistance to various antibiotics such as ceftiofur, ceftriaxone, streptomycin, sulfisoxazole, tetracycline, chloramphenicol, and trimethoprim.
Analysis of Salmonella enterica Isolated from a Mixed-Use Watershed in Georgia, USA: Antimicrobial Resistance, Serotype Diversity, and Genetic Relatedness to Human Isolates.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from a mixed-use watershed in Georgia, USA, including bla CMY-2, aadA2, strA, strB, sul1, sul2, tetA, tetC, floR, and dfrA12, which conferred resistance to various antibiotics such as ceftiofur, ceftriaxone, streptomycin, sulfisoxazole, tetracycline, chloramphenicol, and trimethoprim.
Escherichia coli ST1193: Following in the Footsteps of E. coli ST131
The paper characterizes Escherichia coli ST1193 as an emerging multidrug-resistant clone with various AMR determinants, including beta-lactamases (bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-55, bla OXA-1, bla TEM-1, bla CMY-42, bla CMY-2), aminoglycoside-modifying enzymes (aac(3)-IIa, aac(3)-IId, aac(6′)-Ib-cr, aadA1, aadA2, aadA5, aph(3′′)-Ib, aph(6)-Id), and other resistance genes (mcr-1, mph(A), erm(B), dfrA8, dfrA12, dfrA17, sul1, sul2, tetA, tetB).
Escherichia coli ST1193: Following in the Footsteps of E. coli ST131
The paper characterizes Escherichia coli ST1193 as an emerging multidrug-resistant clone with various AMR determinants, including beta-lactamases (bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-55, bla OXA-1, bla TEM-1, bla CMY-42, bla CMY-2), aminoglycoside-modifying enzymes (aac(3)-IIa, aac(3)-IId, aac(6′)-Ib-cr, aadA1, aadA2, aadA5, aph(3′′)-Ib, aph(6)-Id), and other resistance genes (mcr-1, mph(A), erm(B), dfrA8, dfrA12, dfrA17, sul1, sul2, tetA, tetB).
Retail chicken giblets contaminated with extended-spectrum cephalosporin- and carbapenem-resistant Salmonella enterica carrying blaCMY-2.
The study identified extended-spectrum cephalosporin- and carbapenem-resistant Salmonella enterica in retail chicken giblets, water tanks, and workers, carrying blaTEM, blaSHV, blaCMY-2, blaOXA-1, and blaKPC genes.
Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches.
The study identifies several AMR genes and mutations associated with resistance to various antibiotics in wastewater environments, highlighting the role of these genes in the spread of antimicrobial resistance.
Clustered Regularly Interspaced Short Palindromic Repeats Genotyping of Multidrug-Resistant Salmonella Heidelberg Strains Isolated From the Poultry Production Chain Across Brazil.
The study identified several AMR genes and chromosomal mutations in multidrug-resistant Salmonella Heidelberg strains isolated from the poultry production chain in Brazil, highlighting the widespread distribution of antibiotic-resistant strains.
Direct Colorimetry of Imipenem Decomposition as a Novel Cost-Effective Method for Detecting Carbapenemase-Producing Enterobacteria.
The study presents a novel, cost-effective method for detecting carbapenemase-producing enterobacteria (CPE) using direct colorimetry of imipenem decomposition. The method relies on the specific color change induced by carbapenemases, particularly NDM-1, NMC-A, OXA-48, VIM-1, IMP-4, and KPC-2, which were experimentally validated for their ability to hydrolyze imipenem and produce a measurable yellow color. The method demonstrated high sensitivity (98%) and specificity (100%).
Extended Spectrum β-Lactamase Activity and Cephalosporin Resistance in Escherichia coli from U.S. Mid-Atlantic Surface and Reclaimed Water.
The study identified bla TEM, bla CMY-2, and bla CTX-M genes in Escherichia coli isolates from surface and reclaimed water, contributing to cephalosporin resistance.
Excreted Antibiotics May Be Key to Emergence of Increasingly Efficient Antibiotic Resistance in Food Animal Production.
The study shows that bla CTX-M-15 provides a significant fitness advantage over bla CMY-2 and bla KPC-3 in high concentrations of ampicillin and ceftiofur, suggesting that excreted antibiotics play a crucial role in the emergence of more efficient antibiotic resistance genes in food animal production.
Comparison of the Treatment Outcome of Piperacillin-Tazobactam versus Carbapenems for Patients with Bacteremia Caused by Extended-Spectrum beta-lactamase-Producing Escherichia coli in Areas with Low Frequency of Coproduction of OXA-1: a Preliminary Analysis.
The study found that piperacillin-tazobactam (TZP) may be as effective as carbapenems for treating non-severe cases of ESBL-producing E. coli bacteremia in areas with low frequency of OXA-1 co-production. The most common beta-lactamase identified was bla CTX-M-27, followed by bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, and bla CTX-M-8. Only a small percentage of isolates carried bla OXA-1, which is associated with reduced susceptibility to TZP.
Rapid Detection of Beta-Lactamases Genes among Enterobacterales in Urine Samples by Using Real-Time PCR.
The study developed a real-time PCR system to detect beta-lactamase genes (blaSHV-12, blaTEM, blaCTX-M-15, blaCTX-M-9, blaCMY-2, blaOXA-48, and blaNDM-1) in Enterobacterales strains from urine samples, demonstrating high sensitivity and specificity.
Genomic surveillance of Salmonella spp. in the Philippines during 2013-2014.
The study characterized various AMR genes and mutations in Salmonella isolates from the Philippines, highlighting the presence of ESBL genes, plasmid-mediated quinolone resistance genes, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil.
The study characterizes antimicrobial resistance (AMR) genes and mutations in various Salmonella serovars associated with poultry in Brazil, emphasizing the emergence of multidrug-resistant (MDR) strains. Key findings include the identification of AMR genes such as blaCTX-M-2, blaTEM-1B, aac(3)-lla, aac(3)-lld, aadA1, aadA2, aph(6)-ld, dfrA1, floR, mrc-1, strA, strB, sul1, sul2, tet(A), tet(B), and others, which confer resistance to multiple antibiotics.
High Prevalence of Beta-Lactam-Resistant Escherichia coli in South Australian Grey-Headed Flying Fox Pups (Pteropus poliocephalus).
The study identified various beta-lactam-resistant Escherichia coli strains in South Australian grey-headed flying fox pups, including resistance genes such as blaTEM-1B, blaTEM-1C, blaTEM-33, blaCMY-2, dfrA17, aadA5, dfrA5, sul2, tet(A), tet(B), and catA1.
Prevalence and distribution of extended-spectrum β-lactamase and AmpC-producing Escherichia coli in two New Zealand dairy farm environments.
The study identified bla CMY-2, bla CTX-M-1, bla CTX-M-15, and bla OXA-1 genes in ESBL- and AmpC-producing E. coli isolates from New Zealand dairy farms, highlighting the presence of plasmid-mediated resistance mechanisms.
Prevalence and distribution of extended-spectrum β-lactamase and AmpC-producing Escherichia coli in two New Zealand dairy farm environments.
The study identified bla CMY-2, bla CTX-M-1, bla CTX-M-15, and bla OXA-1 genes in ESBL- and AmpC-producing E. coli isolates from New Zealand dairy farms, highlighting the presence of plasmid-mediated resistance mechanisms.
World Health Organization critical priority Escherichia coli clone ST648 in magnificent frigatebird (Fregata magnificens) of an uninhabited insular environment.
The study identified a multidrug-resistant ST648 E. coli isolate carrying various AMR genes, including blaCTX-M-2, blaCMY-2, qnrB, tetB, sul1, sul2, aadA1, aac(3)-VIa, and mdfA, highlighting the presence of critical priority pathogens in wild birds.
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria.
The study identified several AMR genes in multi-drug resistant E. coli isolates, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-65, bla OXA-1, bla OXA-2, bla CMY-2, bla NDM-1, bla NDM-5, aac(3)-IId, aac(3)-IIe, aac(6')-Ib-cr, aad A5, ant(2′′)-Ia, aph(3′′)-Ib, aph(3′′)-VI, aph(6)-Id, ermB, ermD, fosA3, fosA7, mdtM, emrD, sul1, sul2, sul3, tetA, tetB, tetM, dfrA1, dfrA7, dfrA8, dfrA12, dfrA14, dfrA17, dfrA82, dfrB4, qepA, qepA1, qepA2, qepA4, qnrB19, qnrS1, qacE, catA1, catA2, catB3, cmlA1, mphA.
Characterization of Carbapenemase-Producing Klebsiella pneumoniae Isolates from Two Romanian Hospitals Co-Presenting Resistance and Heteroresistance to Colistin.
The study identifies multiple AMR genes and mutations in carbapenemase-producing Klebsiella pneumoniae isolates, including bla NDM-1, bla OXA-48, and various aminoglycoside-modifying enzymes, as well as mutations in mgrB, gyrA, parC, and porin genes associated with colistin and fluoroquinolone resistance.
Evaluation of the EasyScreen™ ESBL/CPO Detection Kit for the Detection of ß-Lactam Resistance Genes.
The EasyScreen™ ESBL/CPO Detection Kit effectively detects various β-lactam resistance genes, including bla VIM, bla NDM, bla IMP, bla OXA-48, bla KPC, bla OXA-23, bla OXA-51, bla SME, bla IMI, bla GES, bla TEM, bla SHV, bla CTX-M, bla CMY, bla DHA, and the mcr-1 gene, demonstrating high sensitivity and specificity for carbapenemase and ESBL detection in Enterobacterales, Pseudomonas spp., and Acinetobacter spp.
Comparative Genomic Analysis of Antimicrobial-Resistant Escherichia coli from South American Camelids in Central Germany.
The study identified various antimicrobial resistance genes in Escherichia coli isolates from South American camelids in Germany, highlighting the presence of multidrug-resistant strains and the importance of monitoring AMR in these animals.
Resistance and virulence features of hypermucoviscous Klebsiella pneumoniae from bloodstream infections: Results of a nationwide Italian surveillance study.
The study identified various AMR genes in hypermucoviscous Klebsiella pneumoniae isolates, including bla KPC-3, bla KPC-2, CMY-16, CTX-M-15, bla SHV-2, bla DHA-1, bla CTX-M-65, qnr, aadA1, aac(6')-Ib, sul1, dfrA1, mph(A), erm(B), floR, and fosA3. These genes conferred resistance to multiple antibiotics, including carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and fosfomycin.
Acquisition of genomic elements were pivotal for the success of Escherichia coli ST410
The study identified several AMR genes and mutations in Escherichia coli ST410, including bla OXA-181, bla NDM-5, bla CTX-M-15, and mutations in gyrA, parC, and parE that confer resistance to carbapenems, cephalosporins, penicillins, aminoglycosides, sulfonamides, trimethoprim, and fluoroquinolones.
Genome-associations of extended-spectrum ß-lactamase producing (ESBL) or AmpC producing E. coli in small and medium pig farms from Khon Kaen province, Thailand.
The study identifies various AMR genes in ESBL and/or AmpC-producing E. coli from small and medium pig farms in Thailand, highlighting the co-occurrence of resistance genes conferring resistance to critically important antimicrobials.
Antimicrobial Resistance Pattern, Clustering Mechanisms and Correlation Matrix of Drug-Resistant Escherichia coli in Black Bengal Goats in West Bengal, India.
The study identified several AMR genes in multidrug-resistant E. coli isolates from goats, including bla CTXM-1, bla AmpC, bla SHV, bla TEM, bla CMY-6, bla CITM, bla NDM-5, qnr B, qnr S, aac(6')-Ib-cr, tet A, tet B, sul 1, and the acrAB efflux pump system.
Detection of β-Lactamase Resistance and Biofilm Genes in Pseudomonas Species Isolated from Chickens.
The study identified the presence of AmpC beta-lactamase genes (blaCMY, blaMIR, DHA, and FOX) in Pseudomonas isolates from chickens, highlighting their role in beta-lactam resistance.
Antibiotic Susceptibility Profiles and Resistance Mechanisms to β-Lactams and Polymyxins of Escherichia coli from Broilers Raised under Intensive and Extensive Production Systems.
The study identifies several β-lactamase genes, including SHV-12, CTX-M group variants, TEM, OXA, and PMAβ, as well as the mcr-1 gene responsible for polymyxin resistance in E. coli isolates from broilers raised in intensive and extensive systems. The prevalence of reduced susceptibility to antibiotics is higher in isolates from the intensive system.
A survey of antimicrobial-resistant Escherichia coli prevalence in wild mammals in Japan using antimicrobial-containing media.
The study identified several beta-lactamase genes (bla CTX-M-1, bla CTX-M-27, bla CTX-M-55, and bla CMY-2) and the quinolone resistance gene qnrB19 in cefotaxime- and ciprofloxacin-resistant Escherichia coli isolates from wild mammals in Japan.
Prevalence and distribution of ampc beta-lactamase producing escherichia coli and klebsiella pneumoniae isolates obtained from urine samples at a tertiary care hospital in the caribbean.
The study identified bla CIT, bla DHA, and bla CMY-42 as the three AmpC beta-lactamase genes prevalent among cefoxitin-resistant E. coli and K. pneumoniae isolates in Jamaica. These genes conferred resistance to cefoxitin.
Multistate reptile- and amphibian-associated salmonellosis outbreaks in humans, United States, 2009-2018.
The study identified various AMR genes and mutations in Salmonella isolates from multistate reptile- and amphibian-associated salmonellosis outbreaks in the United States, including bla CMY-2, qnrB19, qnrS1, bla TEM-116, bla TEM-1C, bla TEM-1B, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, dfrA12, sul1, sul3, floR, tet(A), and sul2, which conferred resistance to multiple antibiotics such as ciprofloxacin, ceftriaxone, ampicillin, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole, chloramphenicol, and tetracycline.
Dissemination of High-Risk Clones Enterobacterales among Bulgarian Fecal Carriage Isolates.
The study identified several AMR genes, including bla CTX-M-15, bla CTX-M-3, bla CTX-M-27, bla CTX-M-14, bla CTX-M-9, bla SHV-1, bla SHV-11, bla TEM-1, bla NDM-1, bla KPC-2, bla CMY-4, bla DHA-1, and bla CMY-2, which confer resistance to various beta-lactam antibiotics. High-risk clones such as ST11, ST258, and ST15 were found to be prevalent among Klebsiella pneumoniae isolates, while ST131 was the most common among E. coli isolates.
Dissemination of High-Risk Clones Enterobacterales among Bulgarian Fecal Carriage Isolates.
The study identified several AMR genes, including bla CTX-M-15, bla CTX-M-3, bla CTX-M-27, bla CTX-M-14, bla CTX-M-9, bla SHV-1, bla SHV-11, bla TEM-1, bla NDM-1, bla KPC-2, bla CMY-4, bla DHA-1, and bla CMY-2, which confer resistance to various beta-lactam antibiotics. High-risk clones such as ST11, ST258, and ST15 were found to be prevalent among Klebsiella pneumoniae isolates, while ST131 was the most common among E. coli isolates.
Beta-lactamase determinants and molecular typing of carbapenem-resistant classic and hypervirulent Klebsiella pneumoniae clinical isolates from southwest of Iran.
The study identified several beta-lactamase genes, including bla NDM, bla IMP, bla VIM, bla GES, bla OXA-48-like, bla CTX-M, bla SHV, bla TEM, bla FOX, bla DHA, bla CMY, bla LAT, and bla ACT, which are responsible for carbapenem resistance in Klebsiella pneumoniae isolates from southwest Iran.
Antimicrobial resistance and genomic characterization of Salmonella enterica serovar Senftenberg isolates in production animals from the United States.
The study characterized antimicrobial resistance genes and mutations in Salmonella enterica serovar Senftenberg isolates from production animals in the United States, identifying genes such as aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, blaTEM-1B, blaCMY-2, blaSHV-12, floR, catA2, qnrB2, aac(6')-Ib-cr, aadA1, aadA2, sul1, sul2, tetA, and mcr-9.1, along with mutations in gyrA and parC genes contributing to resistance against various antibiotics.
The Genetic Characteristics and Carbapenem Resistance Mechanism of ST307 Klebsiella pneumoniae Coharbouring bla(CMY-6), bla(OXA-48), and a Truncated bla(NDM-1).
The study identified ST307 Klebsiella pneumoniae isolates co-harboring bla(CMY-6), bla(OXA-48), and a truncated bla(NDM-1). bla(CMY-6) significantly elevated carbapenem MICs, while the truncated bla(NDM-1) was non-functional due to IS10 insertion.
A Shigella sonnei clone with extensive drug resistance associated with waterborne outbreaks in China.
The study reports the emergence of XDR Shigella sonnei strains with cef R azi R and col R phenotypes associated with waterborne outbreaks in China, highlighting the role of plasmid-mediated AMR genes such as bla CTX-M-14, mphA, mcr-1, and others in the spread of multidrug resistance.
Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America.
The study identified and characterized several extended-spectrum cephalosporin resistance (ESC-R) genes, including bla CTX-M-1, bla CTX-M-15, bla CMY-2, bla CTX-M-14, and bla SHV-12, in Escherichia coli isolates from Europe and North America. These genes were found to be prevalent in different geographical regions and sources, with varying frequencies and distributions.
Genomic Characterization of ESBL/AmpC-Producing Escherichia coli in Stray Dogs Sheltered in Yangzhou, China.
The study identified several beta-lactamase genes, including bla CTX-M-15, bla CTX-M-55, and others, along with additional resistance genes such as tet(A), qnrS1, and oqxAB, contributing to multidrug resistance in ESBL/AmpC-producing E. coli isolated from stray dogs in Yangzhou, China.
Molecular characterization of extended-spectrum cephalosporin and fluoroquinolone resistance genes in Salmonella and Shigella isolated from clinical specimens in Thailand.
The study identified extended-spectrum beta-lactamase (ESBL) genes such as bla CTX-M-15, bla TEM-1, and bla CMY-2, along with quinolone resistance genes like qnrS and aac(6')-Ib-cr, in Salmonella and Shigella isolates from Thailand. Mutations in gyrA and parC genes were also found to contribute to fluoroquinolone resistance.
Salmonella Heidelberg and Salmonella Minnesota in Brazilian broilers: Genomic characterization of third-generation cephalosporin and fluoroquinolone-resistant strains.
The study identifies multiple AMR genes and mutations in Salmonella Heidelberg and Salmonella Minnesota isolates from Brazilian broilers, including bla CMY-2, qnrB19, aac(6')-Iaa, sul2, tet(A), fosA7, qacE, and formA, along with gyrA(S83F) and parC(T57S) mutations conferring resistance to various antibiotics.
Expanded catalogue of metagenome-assembled genomes reveals resistome characteristics and athletic performance-associated microbes in horse.
The study identified a diverse array of antibiotic resistance genes (ARG) in the horse gut microbiome, highlighting the widespread use of antibiotics in horse management. The resistome characteristics were analyzed alongside the identification of microbes associated with athletic performance.
Comparative genetic characterization of CMY-2-type beta-lactamase producing pathogenic Escherichia coli isolated from humans and pigs suffering from diarrhea in Korea.
The study identified CMY-2-type beta-lactamase encoding genes in third-generation cephalosporin-resistant E. coli isolates from both humans and pigs in Korea. These isolates exhibited multidrug resistance and carried various additional resistance genes.
Multidrug-Resistant ESBL-Producing E. coli in Clinical Samples from the UK.
The study identified several β-lactamase genes (bla CTX-M, bla TEM, bla OXA-1) and integron-related genes (intl1, merA, merC) associated with multidrug resistance in ESBL-producing E. coli isolates from the UK.
Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009-2018.
The study identifies multiple AMR genes associated with multidrug-resistant Salmonella enterica serotype 4,[5],12:i:-, including genes conferring resistance to ampicillin, streptomycin, sulfamethoxazole, tetracycline, ciprofloxacin, ceftriaxone, azithromycin, and colistin. These genes are prevalent in a multidrug-resistant clade linked to pork consumption.
Characterization of Escherichia coli and Other Enterobacterales Resistant to Extended-Spectrum Cephalosporins Isolated from Dairy Manure in Ontario, Canada.
The study identified bla CTX-M and bla CMY genes as major contributors to extended-spectrum cephalosporin resistance in Escherichia coli and other Enterobacterales isolated from dairy manure in Ontario, Canada. These genes were found to be prevalent in various plasmid types and were associated with multidrug resistance.
A Cross-Validated Feature Selection (CVFS) approach for extracting the most parsimonious feature sets and discovering potential antimicrobial resistance (AMR) biomarkers.
The study presents a Cross-Validated Feature Selection (CVFS) approach for identifying the most parsimonious gene sets for predicting antimicrobial resistance (AMR) from bacterial pan-genomes. The CVFS approach was able to extract both known and novel AMR genes, demonstrating its effectiveness in selecting relevant features for AMR prediction.
Hospital-acquired and zoonotic bacteria from a veterinary hospital and their associated antimicrobial-susceptibility profiles: A systematic review.
The study identified several antimicrobial resistance genes, including mecA, blaCMY-2, vanA, and flo, associated with hospital-acquired and zoonotic bacteria in veterinary settings.
Phylogenetic analysis and antibiotic resistance of Escherichia coli isolated from wild and domestic animals at an agricultural land interface area of Salaphra wildlife sanctuary, Thailand.
The study identified several AMR genes in E. coli isolates from wild and domestic animals in Thailand, including blaTEM, blaSHV, blaCMY-2, aac(3)-IV, aadA, tetA, tetB, qnrA, sul3, dfrA1, dfrA5, and dfrA7, which conferred resistance to various antibiotics such as ampicillin, gentamicin, tetracycline, ciprofloxacin, and trimethoprim-sulfamethoxazole.
An ST131 clade and a phylogroup A clade bearing an O101-like O-antigen cluster predominate among bloodstream Escherichia coli isolates from South-West Nigeria hospitals.
The study identified several AMR genes and mutations in bloodstream E. coli isolates from South-West Nigeria, including bla CTX-M-15, dfrA, dfrB, and various quinolone resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
beta-lactamase Producing Escherichia coli Encoding bla(CTX-M) and bla(CMY) Genes in Chicken Carcasses from Egypt.
The study identified bla(CTX-M) and bla(CMY) genes in multidrug-resistant E. coli isolates from chicken carcasses in Egypt, highlighting the presence of extended-spectrum beta-lactamases and AmpC beta-lactamases, which confer resistance to several β-lactam antibiotics.
Trends of β-Lactamase Occurrence Among Escherichia coli and Klebsiella pneumoniae in United States Hospitals During a 5-Year Period and Activity of Antimicrobial Agents Against Isolates Stratified by β-Lactamase Type.
The study identified various β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-27, bla SHV-12, bla SHV-7, bla SHV-27, bla TEM-1, bla TEM-12, bla CMY-2, bla DHA-1, bla FOX-5, bla OXA-1, bla OXA-1-like, bla KPC-2, bla KPC-3, bla NDM-1, bla NDM-5, bla OXA-181, bla OXA-48, and bla OXA-232, which confer resistance to β-lactam antibiotics. The study also found that CTX-M-15 was the most prevalent β-lactamase gene, and there was a notable increase in ESBL-producing isolates among K. pneumoniae.
In silico analyses of diversity and dissemination of antimicrobial resistance genes and mobile genetics elements, for plasmids of enteric pathogens.
The study identifies a diverse array of antimicrobial resistance (AMR) genes across various plasmid replicon types in enteric pathogens, highlighting the prevalence of resistance genes in plasmids such as IncHI2, IncN, IncA/C, IncP, IncHI1, and IncFIA. Key AMR genes include aac(3)-IId, aac(3)-IIg, aac(6')-Ib3, aadA1, aadA5, aph(3'')-Ib, bla CMY-2, bla CTX-M-27, bla NDM-1, mcr-9.1, and others, which confer resistance to antibiotics such as gentamicin, cephalosporins, carbapenems, colistin, and tetracycline.
In silico analyses of diversity and dissemination of antimicrobial resistance genes and mobile genetics elements, for plasmids of enteric pathogens.
The study identifies a diverse array of antimicrobial resistance (AMR) genes across various plasmid replicon types in enteric pathogens, highlighting the prevalence of resistance genes in plasmids such as IncHI2, IncN, IncA/C, IncP, IncHI1, and IncFIA. Key AMR genes include aac(3)-IId, aac(3)-IIg, aac(6')-Ib3, aadA1, aadA5, aph(3'')-Ib, bla CMY-2, bla CTX-M-27, bla NDM-1, mcr-9.1, and others, which confer resistance to antibiotics such as gentamicin, cephalosporins, carbapenems, colistin, and tetracycline.
A Novel CMY Variant Confers Transferable High-Level Resistance to Ceftazidime-Avibactam in Multidrug-Resistant Escherichia coli.
A novel CMY variant, CMY-178, was identified as a cause of high-level resistance to ceftazidime-avibactam in multidrug-resistant E. coli. The gene was found to be transferable via a plasmid with high conjugation frequency and minimal fitness cost.
A Novel CMY Variant Confers Transferable High-Level Resistance to Ceftazidime-Avibactam in Multidrug-Resistant Escherichia coli.
A novel CMY variant, CMY-178, was identified as a cause of high-level resistance to ceftazidime-avibactam in multidrug-resistant E. coli. The gene was found to be transferable via a plasmid with high conjugation frequency and minimal fitness cost.
Silver nanoparticles enhance the efficacy of aminoglycosides against antibiotic-resistant bacteria.
The study identifies several AMR genes, including mcr-1, mcr-3, mcr-4, aadA5, catA1, bla CMY-2, bla CTX-M-55, dfrA17, fosA, mph(A), rmtB, strA, strB, sul1, sul2, bla TEM-1B, and bla CMY-48, which confer resistance to various antibiotics in different bacterial strains.
Silver nanoparticles enhance the efficacy of aminoglycosides against antibiotic-resistant bacteria.
The study identifies several AMR genes, including mcr-1, mcr-3, mcr-4, aadA5, catA1, bla CMY-2, bla CTX-M-55, dfrA17, fosA, mph(A), rmtB, strA, strB, sul1, sul2, bla TEM-1B, and bla CMY-48, which confer resistance to various antibiotics in different bacterial strains.
Antimicrobial resistance profiles of Campylobacter jejuni and Salmonella spp. isolated from enteritis patients in Japan.
The study identified several AMR genes including blaCMY-2, aac(6')-Iaa, ant(3")-Ib, aph(6)-Id, floR, qnrB19, sul2, and tet(A) in cefotaxime-resistant Salmonella isolates. Additionally, mutations in the gyrA gene, specifically Thr86Ile, were found in ciprofloxacin-resistant C. jejuni isolates.
Development of Nanobodies as Theranostic Agents against CMY-2-Like Class C β-Lactamases.
The study identifies three nanobodies (cAb CMY-2 (250), cAb CMY-2 (254), and cAb CMY-2 (272)) that specifically bind to CMY-2 β-lactamase, with cAb CMY-2 (254) showing the highest stability and affinity. These nanobodies act as noncompetitive inhibitors of CMY-2 activity and are used to develop a highly specific sandwich ELISA for detecting CMY-2-producing bacteria.
Extended-Spectrum β-Lactamase Genes Traverse the Escherichia coli Populations of Intensive Care Unit Patients, Staff, and Environment.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-55, bla CTX-M-14, bla CTX-M-15, bla CTX-M-65, bla CTX-M-27, bla CTX-M-3, bla CTX-M-24, bla CMY-146, bla CMY-2, bla DHA-1, and bla TEM, which are responsible for conferring resistance to multiple beta-lactam antibiotics in Escherichia coli isolates from an ICU setting.
Extended-Spectrum β-Lactamase Genes Traverse the Escherichia coli Populations of Intensive Care Unit Patients, Staff, and Environment.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-55, bla CTX-M-14, bla CTX-M-15, bla CTX-M-65, bla CTX-M-27, bla CTX-M-3, bla CTX-M-24, bla CMY-146, bla CMY-2, bla DHA-1, and bla TEM, which are responsible for conferring resistance to multiple beta-lactam antibiotics in Escherichia coli isolates from an ICU setting.
Extended-Spectrum β-Lactamase Genes Traverse the Escherichia coli Populations of Intensive Care Unit Patients, Staff, and Environment.
Extended-Spectrum β-Lactamase Genes Traverse the Escherichia coli Populations of Intensive Care Unit Patients, Staff, and Environment.
Extended-Spectrum β-Lactamase Genes Traverse the Escherichia coli Populations of Intensive Care Unit Patients, Staff, and Environment.
Outbreak of OXA-48-producing Enterobacteriaceae in a neonatal intensive care unit in Western Sweden.
The study describes an outbreak of OXA-48-producing Enterobacteriaceae in a neonatal intensive care unit, identifying the blaOXA-48 and blaCMY-4 genes as responsible for carbapenem and cephalosporin resistance, respectively.
Complete Genetic Analysis of Plasmids Carrying Multiple Resistance, Virulence, and Phage-Like Genes in Foodborne Escherichia coli Isolate.
The study identified 16 antimicrobial resistance genes in a foodborne E. coli strain, including bla NDM-1 and mcr-1, highlighting the dissemination of multidrug-resistant plasmids in food products.
Prevalence and Characterization of Salmonella Isolated from Chickens in Anhui, China.
The study identified several AMR genes in Salmonella isolates from chickens in Anhui, China, including blaTEM, blaCMY-2, aadA, strA, aph(3')-IIa, aac(6')-Ib-cr, qnrB, qnrS, sul1, sul2, tetA, tetB, cat1, and floR. These genes were associated with resistance to various antibiotics such as ampicillin, cephalosporins, streptomycin, gentamicin, amikacin, fluoroquinolones, sulfamethoxazole, tetracycline, chloramphenicol, and florfenicol.
Characterization of cephalosporin and fluoroquinolone resistant Enterobacterales from Irish farm waste by whole genome sequencing.
The study identified several beta-lactamase genes (bla CTX-M-14, bla CTX-M-15, bla CMY-2, bla SHV-12, and bla ACT-14) and a quinolone resistance gene (qnr S1) associated with cephalosporin and fluoroquinolone resistance in Enterobacterales from Irish farm waste. Additionally, mutations in gyr A, par C, and par E were linked to fluoroquinolone resistance.
High frequency of NDM-1 and OXA-48 carbapenemase genes among Klebsiella pneumoniae isolates in central Iran.
The study identified high frequencies of bla TEM, bla CTX-M1, bla SHV, bla CTX-M15, bla CIT, bla CMY-2, bla NDM, bla OXA-48, qnrB, qnrS, qnrA, tetA, tetB, sul1, sul2, int1, and int2 genes in Klebsiella pneumoniae isolates from central Iran, highlighting the prevalence of multidrug-resistant and carbapenem-resistant strains.
Performance of Phenotypic Tests to Detect beta-lactamases in a Population of beta-lactamase Coproducing Enterobacteriaceae Isolates.
The study identified various beta-lactamase genes including CTX-M, CMY, DHA, ACT, NDM, and OXA-48-like in Enterobacteriaceae isolates. These genes were associated with resistance to multiple β-lactam antibiotics. The performance of phenotypic tests for detecting these resistance mechanisms was evaluated.
Antimicrobial resistance and genomic characterization of Salmonella enterica isolates from chicken meat.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from chicken meat, including aminoglycoside, beta-lactam, quinolone, tetracycline, sulfonamide, and phenicol resistance genes. These genes were detected using whole genome sequencing and correlated with phenotypic resistance profiles.
Serotype distribution, trend of multidrug resistance and prevalence of beta-lactamase resistance genes in human Salmonella isolates from clinical specimens in Guizhou, China.
The study identified the prevalence of beta-lactamase resistance genes, including bla TEM, bla CTX-M, bla OXA-1, and bla CMY, in Salmonella isolates from Guizhou, China. These genes conferred resistance to various β-lactam antibiotics.
High prevalence of β-lactam and fluoroquinolone resistance in various phylotypes of Escherichia coli isolates from urinary tract infections in Jiroft city, Iran.
The study identified a high prevalence of β-lactam resistance genes (bla TEM, bla CTX-M, bla SHV, and bla CMY) and fluoroquinolone resistance in E. coli isolates from urinary tract infections in Jiroft, Iran. The most common resistance patterns were observed in phylotypes B2 and D.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
Phenotypic and Genotypic Characteristics of Antimicrobial Resistance in Citrobacter freundii Isolated from Domestic Ducks (Anas platyrhynchos domesticus) in Bangladesh.
The study identified multiple AMR genes in Citrobacter freundii isolates from domestic ducks in Bangladesh, including beta-lactamases (bla TEM-1, bla CMY-2, bla CMY-9, bla CTX-M-14), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tetA, tetB), fluoroquinolone resistance genes (qnrA, qnrB, qnrS), and an aminoglycoside resistance gene (aacC4).
Plasmid-mediated colistin resistance among human clinical Enterobacterales isolates: national surveillance in the Czech Republic.
The study identified mcr-1, mcr-4, and mcr-9 genes in colistin-resistant Enterobacterales isolates from the Czech Republic, highlighting their association with plasmid-mediated resistance and multidrug resistance features.
Plasmid-mediated colistin resistance among human clinical Enterobacterales isolates: national surveillance in the Czech Republic.
The study identified mcr-1, mcr-4, and mcr-9 genes in colistin-resistant Enterobacterales isolates from the Czech Republic, highlighting their association with plasmid-mediated resistance and multidrug resistance features.
Plasmid Diversity and Antimicrobial Resistance Gene Associations in Salmonella
The study characterizes the global distribution of Salmonella plasmids and their associations with antimicrobial resistance, identifying blaCMY-2 as a key gene in a multi-plasmid outbreak associated with beta-lactam resistance.
Development and evaluation of a centrifugal disk system for the rapid detection of multiple pathogens and their antibiotic resistance genes in urinary tract infection.
The study developed a centrifugal disk system (LCD) for the rapid detection of multiple pathogens and their antibiotic resistance genes (ARGs) in urinary tract infections (UTIs). The LCD platform demonstrated high specificity and sensitivity for detecting pathogens and ARGs, including beta-lactamases (SHV, TEM, CTX-M-1 group, CTX-M-9 group), carbapenemases (KPC, NDM, IMP, OXA-23, OXA-24, OXA-48), ampC beta-lactamases (DHA, CMY), glycopeptide resistance (VanA), and methicillin resistance (mecA).
Genome-Based Retrospective Analysis of a Providencia stuartii Outbreak in Rome, Italy: Broad Spectrum IncC Plasmids Spread the NDM Carbapenemase within the Hospital.
The study identifies the presence of bla NDM-1 and rmtC genes on an IncC plasmid in Providencia stuartii, contributing to extensive drug resistance. Additional resistance genes such as aac(6')-Ib3, sul1, bla CMY-6, tet(B), catA3, and aac(2')-Ia were also found.
Genomic epidemiology of nosocomial carbapenemase-producing Citrobacter freundii in sewerage systems in the Helsinki metropolitan area, Finland.
The study identified bla KPC-2 and bla VIM-1 carbapenemase genes, along with various other AMR genes such as aac(6′)-If, aph(6)-Id, aac(3)-IIa, aadA1, dfrA1, sul2, sat2, qnrB, cmlA5, bla OXA-9, bla CMY-79, bla CMY-116, bla TEM-1A, bla CMY-117, bla OXA-10, bla CFE, bla CMY-100, aac(6′)-Ib, aadA2, sul1, qnrS1, qnrB9, mph(E), msr(E), aac(6′)-Iic, and dfrA16 in carbapenemase-producing Citrobacter freundii isolates from hospital environments and municipal wastewater in Finland.
Blab(TEM)-positive Salmonella enterica serovars Agona and Derby are prevalent among food-producing animals in Chongqing, China.
Escherichia ruysiae May Serve as a Reservoir of Antibiotic Resistance Genes across Multiple Settings and Regions.
Evaluation of the synergistic effect of chitosan metal ions (Cu(2+)/Co(2+)) in combination with antibiotics to counteract the effects on antibiotic resistant bacteria.
The study identifies several antibiotic resistance genes, including mecA, blaz, pbp-4, pbp-1, blaTEM, blaCMY, and blaSHV, which are involved in resistance to penicillin in Staphylococcus aureus and Escherichia coli. These genes show reduced expression when treated with chitosan-metal ion nanoparticles in combination with antibiotics.
Genetic relatedness of third-generation cephalosporin-resistant Escherichia coli among livestock, farmers, and patients in Japan.
The study identified CTX-M-14 as the predominant gene among 3GC-resistant E. coli isolates from livestock, farmers, and patients in Japan. Other CTX-M variants such as CTX-M-15, CTX-M-27, and CTX-M-2 were also detected, along with the plasmid-mediated AmpC beta-lactamase gene CMY-2.
An NDM-Producing Escherichia coli Clinical Isolate Exhibiting Resistance to Cefiderocol and the Combination of Ceftazidime-Avibactam and Aztreonam: Another Step Toward Pan-β-Lactam Resistance.
The study identifies an NDM-Producing E. coli isolate with resistance to cefiderocol and the combination of ceftazidime-avibactam and aztreonam, highlighting the emergence of pan-beta-lactam resistance. Key resistance mechanisms include a 12-base pair insertion in ftsI leading to a 4-amino acid duplication in PBP3, a bla CMY-59 gene, and frameshift mutations in the cirA iron transport gene.
Longitudinal study of ESBL/AmpC-producing Enterobacterales strains sharing between cohabiting healthy companion animals and humans in Portugal and in the United Kingdom.
The study identified ESBL/AmpC-producing Enterobacterales strains in healthy companion animals and humans, with bla CTX-M-15 and bla CMY-2 being the most prevalent beta-lactamase genes. Shared E. coli strains were found between companion animals and their human cohabitants in Portugal.
Investigation of multidrug-resistant plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates from Pakistan.
The study identified 34 antimicrobial resistance genes (ARGs) in multidrug-resistant (MDR) plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates in Pakistan, including bla NDM-1, bla OXA-48, and various beta-lactamases, aminoglycoside resistance genes, and others.
Investigation of multidrug-resistant plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates from Pakistan.
The study identified 34 antimicrobial resistance genes (ARGs) in multidrug-resistant (MDR) plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates in Pakistan, including bla NDM-1, bla OXA-48, and various beta-lactamases, aminoglycoside resistance genes, and others.
High carriage rate of extended-spectrum β-lactamase Enterobacterales and diarrheagenic Escherichia coli in healthy donor screening for fecal microbiota transplantation.
The study identified a high carriage rate of extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales and diarrheagenic Escherichia coli among healthy donors screened for fecal microbiota transplantation. Key ESBL genes detected include blaCTX-M-79, blaCTX-M-15, blaCMY-2, and blaDHA-1.
Genome-Based Epidemiologic Analysis of VIM/IMP Carbapenemase-Producing Enterobacter spp., Poland.
The study identified multiple bla VIM and bla IMP genes, along with various other AMR genes, in VIM/IMP carbapenemase-producing Enterobacter spp. in Poland. These genes were associated with different integrons and plasmid types, contributing to the spread of multidrug-resistant strains.
Genomic Characterization of Fecal Escherichia coli Isolates with Reduced Susceptibility to Beta-Lactam Antimicrobials from Wild Hogs and Coyotes.
The study identified beta-lactamase genes (blaCMY-2, blaCTX-M-55, blaCTX-M-27), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aac(3)-IId, aadA5, ant(3")-Ia, aph(3')-Ia, aph(3")-lb, aph(6)-ld), sulfonamide resistance genes (sul1, sul2, sul3), amphenicol resistance gene (floR), trimethoprim resistance genes (dfrA1, dfrA17), and MLS resistance genes (Inu(F), erm(B), mph(A)) in E. coli isolates from coyotes and wild hogs. Additionally, chromosomal mutations in ampC, gyrA, parC, and parE were found to confer resistance to beta-lactam and quinolone antibiotics.
The impact of applying various de novo assembly and correction tools on the identification of genome characterization, drug resistance, and virulence factors of clinical isolates using ONT sequencing.
The study evaluates the impact of various de novo assembly and read correction tools on the identification of antimicrobial resistance (AMR) genes, plasmids, and virulence factors in clinical Escherichia coli isolates using Oxford Nanopore sequencing. It highlights the effectiveness of Flye and Canu in detecting AMR genes and the importance of read correction tools like Medaka and Racon in improving assembly quality and AMR gene detection.
Prevalence of AmpC, ESBL, and colistin resistance genes in Enterobacterales isolated from ready-to-eat food in Algeria.
The study identified the presence of various beta-lactamase genes (bla CTX-M, bla CMY-2, bla TEM, bla OXA-1, and bla SHV) and the mcr-1 gene in Enterobacterales isolated from ready-to-eat foods in Algeria. These genes confer resistance to multiple antibiotics, highlighting the potential public health concerns associated with antimicrobial resistance in food products.
Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.
The study identified various AMR genes in multidrug-resistant Gram-negative pathogens, highlighting the prevalence of bla CTX-M-15, bla CMY-42, bla NDM-5, aadA, bla TEM-1B, bla OXA-232, bla NDM-1, rmtB, rmtC, bla VEB, bla VIM-2, aph(3'), strA/B, bla OXA-23, aph (3′), catB, dfrB, bla VIM-2, fosA, oqxA, oqxB, bla OXA-23, bla CARB, bla OXA-91, bla OXA-51, bla PAO, bla SHV, aph (3′)-Ib, aph (6)-Id, mphE, msrE, ermB, mphA, aadA, rmtB, qnrB, dfrA, sul1, sul2, and fosA7.
In vitro efficacy of humanized regimen of flomoxef against extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae.
Flomoxef showed good bactericidal effects against ESBL-producing E. coli and K. pneumoniae, even with high MIC values. The study identified several CTX-M types (CTX-M-1, CTX-M-9, CTX-M-14, CTX-M-15, CTX-M-28) and AmpC beta-lactamases (DHA, CMY) as significant contributors to resistance.
Prevalence and molecular characterization of cefotaxime-resistant Salmonella strains recovered from retail meat samples in Shenzhen, China, during 2014-2017.
The study identified several beta-lactamase genes, including bla CTX-M-14, bla CTX-M-55, bla CTX-M-65, bla CTX-M-130, bla CTX-M-27, and bla CMY-2, as well as other resistance genes such as qnrS1, qnrB6, mph(A), oqxAB, mcr-1.1, tet(A), tet(B), sul1, sul2, sul3, aac(6')-Ib, aph(3")-Ib, floR, drfA14, drfA1, and Inu(F), which contribute to cefotaxime resistance in Salmonella strains isolated from retail meat samples in Shenzhen, China.
Plasmids conferring resistance to extended-spectrum beta-lactamases including a rare IncN+IncR multireplicon carrying bla(CTX-M-1) in Escherichia coli recovered from migrating barnacle geese ( Branta leucopsis).
The study identified several AMR genes in ESBL/AmpC-producing E. coli isolates from barnacle geese, including bla(CTX-M-1), bla(CTX-M-15), bla(CMY-2), aadA2b, lnu(F), and qnrS1, which confer resistance to various beta-lactams, aminoglycosides, lincomycin, and quinolones.
Plasmids conferring resistance to extended-spectrum beta-lactamases including a rare IncN+IncR multireplicon carrying bla(CTX-M-1) in Escherichia coli recovered from migrating barnacle geese ( Branta leucopsis).
The study identified several AMR genes in ESBL/AmpC-producing E. coli isolates from barnacle geese, including bla(CTX-M-1), bla(CTX-M-15), bla(CMY-2), aadA2b, lnu(F), and qnrS1, which confer resistance to various beta-lactams, aminoglycosides, lincomycin, and quinolones.
Impact of acquired broad-spectrum beta-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam beta-lactamase inhibitors in Escherichia coli.
The study evaluates the impact of various beta-lactamases on the susceptibility of Escherichia coli to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and their combinations with beta-lactamase inhibitors avibactam and taniborbactam.
Impact of acquired broad-spectrum beta-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam beta-lactamase inhibitors in Escherichia coli.
The study evaluates the impact of various beta-lactamases on the susceptibility of Escherichia coli to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and their combinations with beta-lactamase inhibitors avibactam and taniborbactam.
Isolation and Characterization of Carbapenem-Resistant Escherichia coli Carrying bla(NDM) and mcr-1 from Recurrent Urinary Tract Infection Patient.
The study identifies carbapenem-resistant E. coli isolates carrying bla NDM-1, bla NDM-5, mcr-1, and other resistance genes, highlighting their multidrug-resistant nature and the need for monitoring.
Engineering conjugative CRISPR-Cas9 systems for the targeted control of enteric pathogens and antibiotic resistance.
The study demonstrates the use of conjugative CRISPR-Cas9 systems to target and eliminate enteric pathogens and antibiotic resistance genes, including the bla CMY-2 gene encoding a beta-lactamase.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Carbapenemase- and ESBL-Producing Gram-Negative Bacilli Isolated from Patients with Urinary Tract and Bloodstream Infections.
The study identified multiple carbapenemase and ESBL genes, including bla KPC-2, bla KPC-3, bla NDM, bla CTX-M-15, bla CTX-M-27, bla CTX-M-14, bla SHV-187, bla SHV-12, bla OXA-181, and others, highlighting the diversity of beta-lactam resistance mechanisms in Gram-negative bacteria from urinary tract and bloodstream infections.
Analyses of Extended-Spectrum-β-Lactamase, Metallo-β-Lactamase, and AmpC-β-Lactamase Producing Enterobacteriaceae from the Dairy Value Chain in India.
The study identified several β-lactamase genes, including bla CMY, bla MOX, bla FOX, bla EBC, bla DHA, bla CTX-M1, bla SHV, bla TEM, bla VIM, bla IMP, bla SPM, bla SIM, and bla GIM, in Enterobacteriaceae isolates from milk samples in India, highlighting the presence of multidrug-resistant bacteria in the dairy value chain.
Molecular characterization of highly prevalent Escherichia coli and Escherichia marmotae resistant to extended-spectrum cephalosporins in European starlings (Sturnus vulgaris) in Tunisia.
The study identified several extended-spectrum beta-lactamase (ESBL) and AmpC resistance genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-1, bla CMY-2, and bla CMY-62, in Escherichia coli and Escherichia marmotae isolates from European starlings in Tunisia. Additionally, aminoglycoside resistance genes such as aph(6)-Id and aph(3″)-Ib, along with fosA3, sul1, sul2, sul3, drfA1, drfA17, tet(A), and qnrS1 were also characterized.
Molecular characterization of highly prevalent Escherichia coli and Escherichia marmotae resistant to extended-spectrum cephalosporins in European starlings (Sturnus vulgaris) in Tunisia.
The study identified several extended-spectrum beta-lactamase (ESBL) and AmpC resistance genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-1, bla CMY-2, and bla CMY-62, in Escherichia coli and Escherichia marmotae isolates from European starlings in Tunisia. Additionally, aminoglycoside resistance genes such as aph(6)-Id and aph(3″)-Ib, along with fosA3, sul1, sul2, sul3, drfA1, drfA17, tet(A), and qnrS1 were also characterized.
Carbapenem resistance in extensively drug-resistant Salmonella enterica serovar Agona and AmpC β-lactamase-producing S. Infantis.
The study identifies the loss of porins OmpC_378 and OmpD as critical for carbapenem resistance in Salmonella strains producing AmpC or ESBL β-lactamases. It also characterizes several beta-lactamase genes, including bla CTX-M-55, bla TEM-1B, and bla CMY-2, as well as the efflux pump regulatory gene ramAp.
Antimicrobial resistance profiles of salmonella spp. and escherichia coli isolated from fresh nile tilapia (oreochromis niloticus) fish marketed for human consumption.
The study identified various antimicrobial resistance genes in Salmonella spp. and E. coli isolates from Nile tilapia, including beta-lactamases, tetracycline, sulfonamide, trimethoprim, and aminoglycoside resistance genes, indicating the presence of multidrug-resistant strains.
Genome analysis of third-generation cephalosporin-resistant Escherichia coli and Salmonella species recovered from healthy and diseased food-producing animals in Europe.
The study identified various beta-lactamase genes (bla CTX-M-1, bla CTX-M-15, bla CMY-2, bla SHV-12, bla CTX-M-14, bla CTX-M-55) and polymyxin resistance genes (mcr-1, mcr-3, mcr-4) in third-generation cephalosporin-resistant Escherichia coli and Salmonella species from food-producing animals in Europe.
Genomic Analysis of Multidrug-Resistant Escherichia coli Strains Isolated in Tamaulipas, Mexico.
The study identified multiple antimicrobial resistance genes (ARGs) in multidrug-resistant E. coli strains isolated from human clinical, animal, and environmental sources in Tamaulipas, Mexico. These genes include beta-lactamases (bla CTX-M-15, bla OXA-1, bla TEM-1B, bla CMY-2), aminoglycoside resistance genes (aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aadA5, aac3-IIa), sulfonamide resistance genes (sul2, sul3), phenicol resistance gene (catB3), tetracycline resistance genes (tet(A), tet(B)), quaternary ammonium resistance genes (qacE, qacL), macrolide resistance genes (mdfA, mphA), and quinolone resistance gene (qnrB).
Persistent effects of intramammary ceftiofur treatment on the gut microbiome and antibiotic resistance in dairy cattle.
The study identified the persistence of extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M, blaCMY, and blaCfxA, in the gut microbiome of dairy cattle following intramammary ceftiofur treatment. These genes were associated with increased resistance to ceftiofur and were observed to persist for up to 9 weeks post-treatment.
Persistent effects of intramammary ceftiofur treatment on the gut microbiome and antibiotic resistance in dairy cattle.
The study identified the persistence of extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M, blaCMY, and blaCfxA, in the gut microbiome of dairy cattle following intramammary ceftiofur treatment. These genes were associated with increased resistance to ceftiofur and were observed to persist for up to 9 weeks post-treatment.
Genomic Diversity, Antimicrobial Resistance, Plasmidome, and Virulence Profiles of Salmonella Isolated from Small Specialty Crop Farms Revealed by Whole-Genome Sequencing.
The genomic epidemiology of shigellosis in South Africa.
The study identified multidrug-resistant (MDR) strains of Shigella flexneri 2a and Shigella sonnei in South Africa, with specific resistance mechanisms including beta-lactamases blaCMY-2 and blaCMY-4 for cephalosporin resistance, and fluoroquinolone resistance due to mutations in gyrA and parC genes.
The genomic epidemiology of shigellosis in South Africa.
The study identified multidrug-resistant (MDR) strains of Shigella flexneri 2a and Shigella sonnei in South Africa, with specific resistance mechanisms including beta-lactamases blaCMY-2 and blaCMY-4 for cephalosporin resistance, and fluoroquinolone resistance due to mutations in gyrA and parC genes.
Occurrence and temporal distribution of extended-spectrum beta-lactamase-producing Escherichia coli in clams from the Central Adriatic, Italy.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV12, bla CMY-2, bla TEM-1B, bla TEM-106, and bla TEM-126, which confer resistance to various β-lactam antibiotics. Other resistance genes such as aac(6′)-Ib-cr, qnrS1, tet(A), tet(B), tet(M), aadA5, aadA2b, sul1, sul2, sul3, dfrA17, dfrA5, dfrA14, dfrA12, mph(A), cmlA1, catA2, aac(3)-IIa, aac(3)-IId, and lnu(F) were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates from clams in the Central Adriatic.
Draft genome sequence of NDM-5, CMY-42 carrying carbapenem-resistant Escherichia coli.
The study reports the draft genome sequence of a carbapenem-resistant Escherichia coli strain carrying the blaNDM-5 and blaCMY-42 genes, along with mutations in gyrA, parC, and parE that contribute to fluoroquinolone resistance.
The phylogenomic landscape of extended-spectrum beta-lactamase producing Citrobacter species isolated from surface water.
The study identified several beta-lactamase genes, including bla-CMY-101, bla-CMY-59, and bla-CMY-77, as well as the quinolone resistance gene qnrB13, in Citrobacter species isolated from surface water. These genes were found to confer resistance to various antibiotics, highlighting the potential public health risks posed by these multidrug-resistant strains.
The phylogenomic landscape of extended-spectrum beta-lactamase producing Citrobacter species isolated from surface water.
The study identified several beta-lactamase genes, including bla-CMY-101, bla-CMY-59, and bla-CMY-77, as well as the quinolone resistance gene qnrB13, in Citrobacter species isolated from surface water. These genes were found to confer resistance to various antibiotics, highlighting the potential public health risks posed by these multidrug-resistant strains.
The phylogenomic landscape of extended-spectrum beta-lactamase producing Citrobacter species isolated from surface water.
The study identified several beta-lactamase genes, including bla-CMY-101, bla-CMY-59, and bla-CMY-77, as well as the quinolone resistance gene qnrB13, in Citrobacter species isolated from surface water. These genes were found to confer resistance to various antibiotics, highlighting the potential public health risks posed by these multidrug-resistant strains.
The phylogenomic landscape of extended-spectrum β-lactamase producing Citrobacter species isolated from surface water.
The study identified several β-lactamase genes, including bla-CMY-101, bla-CMY-59, and bla-CMY-77, as well as the quinolone resistance gene qnrB13, in Citrobacter species isolated from surface water. These genes were found to confer resistance to various antibiotics, highlighting the potential public health risks posed by these multidrug-resistant strains.
Comparison of the inoculum effect of in vitro antibacterial activity of Imipenem/relebactam and Ceftazidime/avibactam against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae.
The study evaluated the inoculum effect of Imipenem/relebactam (IMR) and Ceftazidime/avibactam (CZA) against ESBL-, KPC-, and AmpC-producing E. coli and K. pneumoniae. It identified several beta-lactamase genes, including bla TEM-1, bla AmpC, bla CTX-M-14, bla OXA-10, bla CTX-M-55, bla CMY-42, bla CTX-M-15, bla KPC-2, bla OXA-9, bla SHV-182, bla SHV-18, bla OXA-2, bla OKP-B-7, bla DHA-1, bla SHV-27, bla CTX-M-65, bla SHV-11, bla SHV-145, bla SHV-12, bla SHV-106, bla SHV-110, bla SHV106, and bla CTX-M-14, which confer resistance to ceftazidime and/or imipenem.
Within-host genetic diversity of extended-spectrum beta-lactamase-producing Enterobacterales in long-term colonized patients.
The study characterizes various AMR genes, including bla CTX-M-15, bla TEM-1B, bla OXA-1, qnrB1, qnrS1, aph(6)-Id, aph(3”)-Ib, aac(3)-IIa, ant(3”)-Ia, dfrA14, dfrA1, aac(6’)-Ib-cr, tet(A), tet(D), sul2, sul1, fosA6, fosA_5, fosA_3, bla CTX-M-1, bla CTX-M-14, bla CTX-M-14b, bla CTX-M-8, bla CMY-2, bla TEM-190, aac(3)-IVa, aph(4)-Ia, and catB3_2, in ESBL-producing Enterobacterales isolates from long-term colonized patients.
Structural insights into the molecular mechanism of high-level ceftazidime-avibactam resistance conferred by CMY-185.
CMY-185, a CMY-2 variant with four amino acid substitutions (A114E, Q120K, V211S, and N346Y), confers high-level resistance to ceftazidime-avibactam. The N346Y substitution is critical for avibactam resistance and structural changes, while Q120K enhances avibactam resistance, and V211S increases cephalosporin hydrolysis turnover rate.
Impact of systemic antimicrobial therapy on the faecal microbiome in symptomatic dairy cows.
The study identified AmpC-producing Escherichia coli strains carrying the blaCMY-2 gene, which conferred resistance to third-generation cephalosporins. Other resistance genes such as aph(6)-Id, dfrA14, and sul2 were also detected, providing resistance to streptomycin, trimethoprim, and sulfonamides, respectively.
Escherichia coli sequence type 410 with carbapenemases: a paradigm shift within E. coli toward multidrug resistance.
The study identifies multiple AMR genes and mutations in E. coli ST410, including bla CTX-M-15, bla OXA-181, bla NDM-5, and bla CMY-2, along with QRDR mutations in gyrA and parC, and ftsI, ompC, and ompF mutations contributing to beta-lactam resistance.
Modeling the limits of detection for antimicrobial resistance genes in agri-food samples: a comparative analysis of bioinformatics tools.
The study evaluates the detection limits of antimicrobial resistance genes (ARGs) in agri-food metagenomes using various bioinformatics tools. It identifies specific ARGs and their resistance profiles, highlighting challenges in accurate detection at low coverage levels.
Genotypic Characterization of Uropathogenic Escherichia coli from Companion Animals: Predominance of ST372 in Dogs and Human-Related ST73 in Cats.
The study identified several AMR genes and mutations in uropathogenic E. coli isolates from companion animals, including blaTEM-1B, sul2, tet(A), qnrS1, aac(6')-Ib-c, qnrS2, qnrB19, qnrB4, CTX-M-15, CTX-M-27, CMY-2, DHA-1, blaEC, blaEC-6, and mcr-4.6. Mutations in gyrA (S83L, D87N) and parC (S80I) were also found to confer fluoroquinolone resistance.
Clonal and plasmidic dissemination of critical antimicrobial resistance genes through clinically relevant ExPEC and APEC-like lineages (ST) in the dairy cattle population of Québec, Canada.
The study identifies the dissemination of critical AMR genes, including bla CTX-M-15, qnrS1, and bla TEM-1, in E. coli isolates from dairy cattle in Quebec, highlighting the persistence of these genes through plasmids and clones despite reduced antimicrobial use.
Anthropogenic contamination sources drive differences in antimicrobial-resistant Escherichia coli in three urban lakes.
The study identified various AMR genes and mutations in E. coli isolates from three urban lakes, highlighting the impact of anthropogenic contamination on AMR patterns. Key findings include the presence of bla CTX-M, bla TEM, bla CMY, aac(6')-Ib-cr, and mutations in gyrA and parC conferring resistance to multiple antibiotics.
Multidrug resistance plasmids commonly reprogram the expression of metabolic genes in Escherichia coli.
The study identifies various multidrug resistance (MDR) plasmids carrying resistance genes such as bla CMY-2, bla CTX-M, bla NDM-1, and mcr-3.4, which reprogram the expression of metabolic genes in E. coli, affecting pathways related to L-methionine and L-arginine metabolism.
Genetic Diversity of Salmonella enterica subsp. enterica Serovar Enteritidis from Human and Non-Human Sources in Portugal.
The study identified several AMR genes and mutations in Salmonella enterica subsp. enterica serovar Enteritidis isolates from human and non-human sources in Portugal, including blaTEM-1A, blaTEM-1B, blaCMY-2, aac(6')-Iaa, sul1, and aaDA1, as well as mutations in gyrA associated with fluoroquinolone resistance.
Antimicrobial Resistance in Salmonella spp. from Food-Producing Animals and Human Cases in the EU
The study identifies several AMR genes, including bla CTX-M-1, bla CTX-M-14b, bla SHV-12, tet(X3), and tet(X4), in Salmonella isolates from food-producing animals and human cases in the EU. These genes confer resistance to various antibiotics, highlighting the spread of multidrug-resistant Salmonella strains.
Genomic characterization of extended-spectrum beta-lactamase-producing and carbapenem-resistant Escherichia coli from urban wastewater in Australia.
The study identifies multiple AMR genes and mutations in carbapenem-resistant and ESBL-producing E. coli isolates from Australian wastewater, highlighting the presence of resistance mechanisms such as bla NDM-5, bla CMY-42, and mutations in gyrA, parC, and parE.
Genomic characterization of extended-spectrum beta-lactamase-producing and carbapenem-resistant Escherichia coli from urban wastewater in Australia.
The study identifies multiple AMR genes and mutations in carbapenem-resistant and ESBL-producing E. coli isolates from Australian wastewater, highlighting the presence of resistance mechanisms such as bla NDM-5, bla CMY-42, and mutations in gyrA, parC, and parE.
Transferable AmpCs in Klebsiella pneumoniae: interplay with peptidoglycan recycling, mechanisms of hyperproduction, and virulence implications.
The study identifies blaDHA-1 and blaCMY-2 as transferable AmpC beta-lactamases in Klebsiella pneumoniae, highlighting their roles in beta-lactam resistance and the potential for hyperproduction through chromosomal mutations, particularly in mpl.
Comparison of genotypic and phenotypic antimicrobial resistance profiles of Salmonella enterica isolates from poultry diagnostic specimens.
The study identified 31 AMR genes in 97 Salmonella enterica isolates from poultry, including aac(3)-IId, aac(3)-IVa, aac(3)-VIa, aac(6′)-Ib4, ant(2′′)-Ia, grdA, aph(3′)-Ia, aph(3′)-IIa, aadA1, aadA2, aadA7, aadA13, aph(3′)-Ib, aph(6)-Ic, aph(6)-Id, aph(4)-Ia, blaCMY-2, blaCTX-M-1, blaHER-3, blaTEM-1, floR, tetA, tetB, tetC, dfrA12, sul1, sul2, fosA7, qnrB19, ble, and mcr-9.
A sophisticated virulence repertoire and colistin resistance of Citrobacter freundii ST150 from a patient with sepsis admitted to ICU in a tertiary care hospital in Uganda, East Africa: Insight from genomic and molecular docking analyses.
Citrobacter freundii strain RSM030 was found to possess chromosomal beta-lactam resistance genes (blaCMY-79, blaCMY-116, blaTEM-1B) and polymyxin resistance genes (arnD, arnT, eptA, eptB) that confer resistance to multiple antibiotics, including colistin. Additionally, mutations in PmrA/PmrB, mgrB, and PhoP/PhoQ were associated with colistin resistance.
A sophisticated virulence repertoire and colistin resistance of Citrobacter freundii ST150 from a patient with sepsis admitted to ICU in a tertiary care hospital in Uganda, East Africa: Insight from genomic and molecular docking analyses.
Citrobacter freundii strain RSM030 was found to possess chromosomal beta-lactam resistance genes (blaCMY-79, blaCMY-116, blaTEM-1B) and polymyxin resistance genes (arnD, arnT, eptA, eptB) that confer resistance to multiple antibiotics, including colistin. Additionally, mutations in PmrA/PmrB, mgrB, and PhoP/PhoQ were associated with colistin resistance.
What Contributes to the Minimum Inhibitory Concentration? Beyond beta-lactamase Gene Detection in Klebsiella pneumoniae.
The study highlights the complex interplay between beta-lactamases and outer membrane porins in determining β-lactam resistance in Klebsiella pneumoniae. Plasmid-encoded beta-lactamases such as CTX-M-14, CTX-M-15, CMY-2, and DHA-1, as well as chromosomal SHV-5, were found to confer resistance to various β-lactam antibiotics. Additionally, loss of outer membrane porins OmpK35, OmpK36, and PhoE was associated with meropenem resistance.
Comparison of IncK-bla(CMY-2) Plasmids in Extended-Spectrum Cephalosporin-Resistant Escherichia coli Isolated from Poultry and Humans in Denmark, Finland, and Germany.
The study characterizes IncK-bla(CMY-2) plasmids in extended-spectrum cephalosporin-resistant E. coli isolates from poultry and humans in Denmark, Finland, and Germany, identifying multiple resistance genes including bla(CMY-2), aadA1, aac(3)-Vla, aph(3")-Ib, aph(6)-Id, aac(3)-IId, aadA5, aph(3′)-Ia, sul1, sul2, tet(A), tet(B), and bla TEM-1B.
Multidrug resistance in Salmonella isolates of swine origin: mobile genetic elements and plasmids associated with cephalosporin resistance with potential transmission to humans.
The study identifies bla CMY-2 and bla CTX-M-9 genes in Salmonella isolates from swine, which confer resistance to cephalosporins. These genes are located on conjugative plasmids, highlighting the potential for horizontal gene transfer to humans.
Tracking antimicrobial resistance transmission in urban and rural communities in Bangladesh: a One Health study of genomic diversity of ESBL-producing and carbapenem-resistant Escherichia coli.
The study identified various beta-lactamase genes, including bla CTX-M-15, bla TEM-1b, bla OXA-1, and carbapenem resistance genes like bla NDM-5, bla NDM-7, and bla NDM-1, in ESBL-producing and carbapenem-resistant E. coli isolates from Bangladesh.
Emergence of NDM-producing Enterobacterales infections in companion animals from Argentina.
The study reports the first molecular characterization of NDM-producing Enterobacterales causing infections in companion animals from Argentina, identifying bla NDM-1 and bla NDM-5 variants along with ESBLs and AmpC genes.
Assessment of three antibiotic combination regimens against Gram-negative bacteria causing neonatal sepsis in low- and middle-income countries.
The study identifies multiple AMR genes and mutations in Gram-negative bacteria causing neonatal sepsis in LMICs, including ESBLs, carbapenemases, and aminoglycoside-modifying enzymes, highlighting the high prevalence of multidrug resistance and the need for effective antibiotic combinations.
Antimicrobial resistance and population genomics of emerging multidrug-resistant Salmonella 4,[5],12:i:- in Guangdong, China.
The study identified multiple AMR genes and mutations in Salmonella 4,[5],12:i:- isolates from Guangdong, China, including gyrA mutations, PMQR genes, and various beta-lactamase genes, contributing to multidrug resistance.
Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are genetically related but distinct from those causing prostatic abscesses.
The study identifies multiple AMR genes and mutations in multidrug-resistant E. coli strains causing infections in dogs and cats, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla CMY-2, bla CMY-148, aac(6')-Ib-cr, qnrS1, qnrB6, aadA2, aadA5, aadA16, ant(3′′)-Ia, aph(3′)-Ia, aph(3′′)-Ib, aph(6)-Id, rmtB, floR, cmlA, catA, sul1, sul2, sul3, dfrA12, dfrA14, dfr17, dfrA27, tet(A), tet(B), tet(M), mph(A), erm(B), lnu(F), and arr-3, as well as the gyrA:p.S83L mutation.
Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are genetically related but distinct from those causing prostatic abscesses.
The study identifies multiple AMR genes and mutations in multidrug-resistant E. coli strains causing infections in dogs and cats, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla CMY-2, bla CMY-148, aac(6')-Ib-cr, qnrS1, qnrB6, aadA2, aadA5, aadA16, ant(3′′)-Ia, aph(3′)-Ia, aph(3′′)-Ib, aph(6)-Id, rmtB, floR, cmlA, catA, sul1, sul2, sul3, dfrA12, dfrA14, dfr17, dfrA27, tet(A), tet(B), tet(M), mph(A), erm(B), lnu(F), and arr-3, as well as the gyrA:p.S83L mutation.
Rumi and Pasteurized Kareish Cheeses Are a Source of β-Lactam-Resistant Salmonella in the Nile Delta Region of Egypt: Insights into Their Incidence, AMR Pattern, Genotypic Determinants of Virulence and β-Lactam Resistance.
The study identifies several β-lactam resistance genes, including bla OXA-1, bla OXA-2, bla TEM-1, bla CTX-M, bla CMY-1, and bla CMY-2, in β-lactam-resistant Salmonella isolates from Rumi and pasteurized Kareish cheeses in the Nile Delta region of Egypt.
Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization.
The study identified OXA-48 carbapenemase in 82.9% of K. pneumoniae isolates and NDM in 7.3%. bla CTX-M-15, bla SHV, and bla OXA-1 were also detected. Additionally, aac(6")-Ib, dfrA14, oqxA, and oqxB were found to confer resistance to aminoglycosides, trimethoprim, and fluoroquinolones.
Characterizing carbapenemase-producing Escherichia coli isolates from Spain: high genetic heterogeneity and wide geographical spread.
The study identifies various carbapenemase genes such as bla OXA-48, bla VIM-1, bla NDM-1, bla KPC-3, and bla NDM-5 in carbapenem-resistant E. coli isolates from Spain, highlighting their genetic diversity and geographic distribution.
Monitoring Changes in the Antimicrobial-Resistance Gene Set (ARG) of Raw Milk and Dairy Products in a Cattle Farm, from Production to Consumption.
The study identified 112 antibiotic-resistance genes in raw milk and dairy products, with a significant increase in resistant genes in aged cheese compared to raw milk. Key genes included OXA-662 and OXA-309, which confer resistance to beta-lactam antibiotics, and several efflux pump genes like abaQ, emrA, and acrAB-tolC, which contribute to fluoroquinolone resistance. The findings highlight the dynamic changes in the resistome during food processing and the potential public health risks associated with the spread of antibiotic resistance genes through raw dairy products.
The IncC and IncX1 resistance plasmids present in multi-drug resistant Escherichia coli strains isolated from poultry manure in Poland.
The study identifies three resistance plasmids (pECmdr13.2, pECmdr13.3, pECmdr14.1) in multi-drug resistant E. coli strains from poultry manure in Poland, each carrying various AMR genes including tetracycline, aminoglycoside, beta-lactam, sulfonamide, fluoroquinolone, and phenicol resistance genes.
Host species shapes genotype, antimicrobial resistance, and virulence profiles of enterotoxigenic Escherichia coli (ETEC) from livestock in the United States.
The study identifies distinct antimicrobial resistance (AMR) gene profiles in bovine and swine enterotoxigenic Escherichia coli (ETEC) isolates, highlighting differences in the prevalence of specific AMR genes and plasmid replicons between the two host species.
Phenotypic and Genotypic Characterization of AmpC Beta-Lactamase in Clinical Isolates of Pseudomonas aeruginosa Findings From a Tertiary Care Hospital.
The study identified blaPDC and blaCMY genes as the primary contributors to AmpC beta-lactamase production in Pseudomonas aeruginosa isolates, with blaPDC being the most prevalent.
Evolution of the Antibiotic Resistance Levels, Multi-Resistance Patterns, and Presence of Antibiotic Resistance Genes in E. coli Isolates from the Feces of Breeding Hens during the Rearing Period.
The study identified several antibiotic resistance genes in E. coli isolates from breeding hens, including bla TEM, bla SHV, qnr B, and bla CMY-2. These genes were associated with resistance to various antibiotics, and their prevalence varied across different stages of hen rearing.
Phylogenetics and Mobilization of Genomic Traits of Cephalosporin-Resistant Escherichia coli Originated from Retail Meat.
The study identified multiple AMR genes in cephalosporin-resistant E. coli from retail meat, including bla CTX-M-1, bla SHV-12, bla CMY-2, and others, highlighting the role of mobile genetic elements in the spread of resistance.
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape.
The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.
Assessment of the presence of multidrug-resistant Escherichia coli, Salmonella and Staphylococcus in chicken meat, eggs and faeces in Mymensingh division of Bangladesh.
The study identified multiple AMR genes in E. coli, Salmonella spp., and Staphylococcus aureus isolated from chicken meat, eggs, and faeces in Bangladesh, highlighting the presence of multidrug-resistant pathogens.
Isolation and Characterization of Extended-Spectrum beta-lactamase Producing Escherichia coli from Pig Farms and Slaughterhouse.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M1, bla CMY-2, bla OXA1, and bla NDM1, in Escherichia coli isolates from pig farms and slaughterhouses in India.
Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying bla(NDM-5) and bla(KPC-3) from foreign fighters evacuated from Ukraine.
The study identifies bla(NDM-5), bla(KPC-3), and bla(CMY-145) as key contributors to carbapenem and cephalosporin resistance in E. coli ST-361 isolates, alongside a PBP3 YRIN insertion that enhances resistance to cefiderocol and aztreonam/avibactam.
Predominance of enterotoxigenic Escherichia coli among ESBL/plasmid-mediated AmpC-producing strains isolated from diarrheic foals: a public health concern.
The study identified ESBL and pAmpC-producing E. coli strains in diarrheic foals, highlighting the presence of bla TEM, bla CTX-M, bla SHV, bla OXA, and bla CMY-2 genes, along with the heat-stable enterotoxin (ST) gene, indicating a public health concern.
Relative inhibitory activities of newly developed diazabicyclooctanes, boronic acid derivatives, and penicillin-based sulfone beta-lactamase inhibitors against broad-spectrum AmpC beta-lactamases.
The study evaluates the inhibitory activities of various beta-lactamase inhibitors against a wide range of AmpC beta-lactamases, identifying the effectiveness of certain inhibitors like durlobactam and zidebactam in reducing the MIC values of β-lactam antibiotics against AmpC-producing strains.
Relative inhibitory activities of newly developed diazabicyclooctanes, boronic acid derivatives, and penicillin-based sulfone beta-lactamase inhibitors against broad-spectrum AmpC beta-lactamases.
The study evaluates the inhibitory activities of various beta-lactamase inhibitors against a wide range of AmpC beta-lactamases, identifying the effectiveness of certain inhibitors like durlobactam and zidebactam in reducing the MIC values of β-lactam antibiotics against AmpC-producing strains.
Investigation of Citrobacter freundii clinical isolates in a Chinese hospital during 2020-2022 revealed genomic characterization of an extremely drug-resistant C. freundii ST257 clinical strain GMU8049 co-carrying bla(NDM-1) and a novel bla(CMY) variant.
The study identified an extremely drug-resistant C. freundii strain GMU8049 co-carrying bla(NDM-1) and a novel bla(CMY) variant, along with a mutation in ompK37 contributing to carbapenem resistance.
Investigation of Citrobacter freundii clinical isolates in a Chinese hospital during 2020-2022 revealed genomic characterization of an extremely drug-resistant C. freundii ST257 clinical strain GMU8049 co-carrying bla(NDM-1) and a novel bla(CMY) variant.
The study identified an extremely drug-resistant C. freundii strain GMU8049 co-carrying bla(NDM-1) and a novel bla(CMY) variant, along with a mutation in ompK37 contributing to carbapenem resistance.
Genomic Characterization of 16S rRNA Methyltransferase-Producing Enterobacterales Reveals the Emergence of Klebsiella pneumoniae ST6260 Harboring rmtF, rmtB, bla(NDM-5), bla(OXA-232) and bla(SFO-1) Genes in a Cancer Hospital in Bulgaria.
The study identifies the emergence of Klebsiella pneumoniae ST6260 harboring multiple AMR genes, including rmtF, rmtB, bla(NDM-5), bla(OXA-232), and bla(SFO-1), highlighting the complexity of resistance mechanisms in Enterobacterales.
Novel plasmid-mediated CMY variant (CMY-192) conferring ceftazidime-avibactam resistance in multidrug-resistant Escherichia coli.
The study identifies a novel plasmid-mediated CMY variant, CMY-192, which confers high-level resistance to ceftazidime-avibactam in multidrug-resistant Escherichia coli.
Novel plasmid-mediated CMY variant (CMY-192) conferring ceftazidime-avibactam resistance in multidrug-resistant Escherichia coli.
Novel plasmid-mediated CMY variant (CMY-192) conferring ceftazidime-avibactam resistance in multidrug-resistant Escherichia coli.
Novel plasmid-mediated CMY variant (CMY-192) conferring ceftazidime-avibactam resistance in multidrug-resistant Escherichia coli.
Novel plasmid-mediated CMY variant (CMY-192) conferring ceftazidime-avibactam resistance in multidrug-resistant Escherichia coli.
Novel plasmid-mediated CMY variant (CMY-192) conferring ceftazidime-avibactam resistance in multidrug-resistant Escherichia coli.
Novel plasmid-mediated CMY variant (CMY-192) conferring ceftazidime-avibactam resistance in multidrug-resistant Escherichia coli.
Novel plasmid-mediated CMY variant (CMY-192) conferring ceftazidime-avibactam resistance in multidrug-resistant Escherichia coli.
Novel plasmid-mediated CMY variant (CMY-192) conferring ceftazidime-avibactam resistance in multidrug-resistant Escherichia coli.
Genomic characterization of a clonal emergent Salmonella Minnesota lineage in Brazil reveals the presence of a novel megaplasmid of resistance and virulence.
The study identifies multidrug resistance genes such as bla CMY-2, sul2, tet (A), and qnrB19 in a clonal emergent Salmonella Minnesota lineage in Brazil, along with a novel megaplasmid pESM carrying resistance and virulence factors.
Public health concern of antimicrobial resistance and virulence determinants in E. coli isolates from oysters in Egypt.
The study identified multiple AMR genes in E. coli isolates from oysters in Egypt, including bla TEM, bla CTX-M, bla SHV, bla OXA-1, bla CMY-2, bla KPC, bla NDM, bla OXA-48, and bla VIM, as well as virulence genes such as papC, sfa, exhA, eaeA, and estA.
Assessment of Bacterial Contamination and Antimicrobial Resistance of Escherichia coli Isolates from Slovak Dairy Farms.
The study identified several antimicrobial resistance genes in E. coli isolates from Slovak dairy farms, including bla TEM, bla SHV, bla CMY, sul 1, sul 2, tet B, and qnr S, which confer resistance to various antibiotics such as beta-lactams, sulfonamides, tetracyclines, and quinolones.
Insights into Acinetobacter baumannii AMA205's Unprecedented Antibiotic Resistance.
The study identifies the presence of multiple antibiotic resistance genes, including bla_CMY-6, bla_NDM-1, and bla_OXA-23, in the Acinetobacter baumannii strain AMA205, contributing to its high resistance to various antibiotics.
Performance of a hybrid capture-based target enrichment next-generation sequencing for the identification of respiratory pathogens and resistance-associated genes in patients with severe pneumonia.
The study evaluated the performance of RPIP for detecting respiratory pathogens and AMR genes in patients with severe pneumonia. RPIP showed superior sensitivity in detecting bacteria, viruses, and fungi compared to FilmArray-PN and culture methods. It identified several AMR genes, including bla CTX-M, bla OXA, bla CMY, bla OXA, bla SHV, bla IMP, bla NDM, and mec A/C & MREJ, which confer resistance to various antibiotics.
Escherichia coli from six European countries reveals differences in profile and distribution of critical antimicrobial resistance determinants within One Health compartments, 2013 to 2020.
The study identified various AMR genes in E. coli isolates from different sources in six European countries, highlighting differences in resistance profiles and the prevalence of specific resistance mechanisms such as beta-lactamases, quinolone resistance genes, and tetracycline resistance genes.
First Detection of High-Level Aminoglycoside-Resistant Klebsiella pneumoniae and Enterobacter cloacae Isolates Due to 16S rRNA Methyltransferases with and Without bla(NDM) in Uruguay.
The study identifies the first detection of high-level aminoglycoside-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates in Uruguay, carrying 16S rRNA methyltransferases (rmtB, rmtC, rmtD) along with carbapenemase genes (bla NDM-5, bla NDM-1).
AmpC beta-lactamases detected in Southeast Asian Escherichia coli and Klebsiella pneumoniae.
The study identifies various beta-lactamase genes, including bla CMY-2, bla CMY-42, bla DHA-1, bla NDM-5, bla OXA-1, and bla TEM-1, which confer resistance to multiple antibiotics in Escherichia coli and Klebsiella pneumoniae isolates from Southeast Asia.
AmpC beta-lactamases detected in Southeast Asian Escherichia coli and Klebsiella pneumoniae.
The study identifies various beta-lactamase genes, including bla CMY-2, bla CMY-42, bla DHA-1, bla NDM-5, bla OXA-1, and bla TEM-1, which confer resistance to multiple antibiotics in Escherichia coli and Klebsiella pneumoniae isolates from Southeast Asia.
ESBL- and pAmpC-producing Enterobacterales from Swedish dogs and cats 2017-2021: a retrospective study.
The study identified bla CMY-2, bla CTX-M-15, and bla CTX-M-27 as the predominant ESBL/pAmpC genes in ESBL/pAmpC-producing Enterobacterales from Swedish dogs and cats.
National Multicenter Study on the Prevalence of Carbapenemase-Producing Enterobacteriaceae in the Post-COVID-19 Era in Argentina: The RECAPT-AR Study.
The study identified bla NDM, bla KPC, and bla OXA-163 as the main carbapenemase genes in Enterobacterales isolates from Argentina, with NDM and KPC being the most prevalent.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Highly drug resistant clone of Salmonella Kentucky ST198 in clinical infections and poultry in Zimbabwe.
The study identifies multiple AMR genes and mutations in Salmonella Kentucky ST198 strains from Zimbabwe, highlighting their multidrug resistance and the presence of specific resistance mechanisms such as blaCTX-M-14.1 and mutations in gyrA and parC.
Molecular epidemiology of beta-lactamases in ceftriaxone-resistant Enterobacterales bloodstream infections in the mid-Atlantic United States.
The study identified various beta-lactamase genes including bla CTX-M, bla SHV, bla OXY, bla VEB, bla CMY-59, and bla DHA-1 in ceftriaxone-resistant Enterobacterales. Additionally, mutations in the promoter or attenuator regions of the c-ampC gene in E. coli were investigated, but they did not significantly contribute to ceftriaxone resistance.
Characterization of extended-spectrum beta-lactamase-producing Enterobacteriaceae from recreational water in Athens, GA, using an undergraduate laboratory module.
The study characterized the presence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in recreational water samples from Athens, GA, focusing on the detection of bla CTX-M, bla TEM, and bla CMY-2 genes using PCR.
Molecular characterization of uropathogenic Escherichia coli (UPEC) strains isolated from companion dogs and cats in Korea.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including blaTEM-1, blaCTX-M-15, blaCTX-M-55, blaCTX-M-14, blaCTX-M-27, blaCMY-2, blaCMY-2-like, blaCMY-42, blaCMY-102, and blaNDM-5, in UPEC strains from companion dogs and cats in Korea. These genes conferred resistance to various beta-lactam antibiotics such as ampicillin, cefotaxime, and cefoxitin.
Molecular characterization of uropathogenic Escherichia coli (UPEC) strains isolated from companion dogs and cats in Korea.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including blaTEM-1, blaCTX-M-15, blaCTX-M-55, blaCTX-M-14, blaCTX-M-27, blaCMY-2, blaCMY-2-like, blaCMY-42, blaCMY-102, and blaNDM-5, in UPEC strains from companion dogs and cats in Korea. These genes conferred resistance to various beta-lactam antibiotics such as ampicillin, cefotaxime, and cefoxitin.
Molecular characterization of uropathogenic Escherichia coli (UPEC) strains isolated from companion dogs and cats in Korea.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including blaTEM-1, blaCTX-M-15, blaCTX-M-55, blaCTX-M-14, blaCTX-M-27, blaCMY-2, blaCMY-2-like, blaCMY-42, blaCMY-102, and blaNDM-5, in UPEC strains from companion dogs and cats in Korea. These genes conferred resistance to various beta-lactam antibiotics such as ampicillin, cefotaxime, and cefoxitin.
Molecular analysis of AmpC-producing Escherichia coli isolated from pediatric patients.
The study identified plasmid-mediated AmpC genes blaDHA-1 and blaCMY-2, as well as chromosomal ampC mutations in pediatric E. coli isolates, contributing to cephalosporin resistance.
Tracing the evolution: the rise of Salmonella Thompson co-resistant to clinically important antibiotics in China, 1997-2020.
The study identifies the IncC plasmid as a major driver of co-resistance to ciprofloxacin, cefotaxime, and azithromycin in Salmonella Thompson isolates in China, with specific resistance genes including qnrS1, qepA4, blaCMY-2, and mph(A).
Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
The study identified various AMR genes and mutations in Salmonella Enteritidis isolates from Spain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and aminoglycoside resistance genes. Chromosomal mutations in the gyrA gene were also found to contribute to quinolone resistance.
Identification of CMY-190, a novel chromosomally encoded AmpC beta-lactamase, and plasmid-encoded KPC-2 in a clinical isolate of Citrobacter youngae.
The study identifies a novel chromosomally encoded AmpC beta-lactamase gene, bla CMY-190, and a plasmid-encoded carbapenemase gene, bla KPC-2, in a clinical isolate of Citrobacter youngae.
Next-generation diagnostics of bloodstream infections enabled by rapid whole-genome sequencing of bacterial cells purified from blood cultures.
The study presents a rapid whole-genome sequencing workflow (LC-WGS) for diagnosing bloodstream infections, demonstrating accurate identification of bacterial pathogens and detection of clinically relevant resistance markers within 4.2 hours. The workflow successfully identified various AMR genes, including bla CTX-M-15, bla DHA-1, bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-23, armA, mecA, vanRSHAXYZ, aac(6')-Ie/aph(2'')-Ia, aph(3')-IIIa, aac(6')-I, sul1, and dfrA17.
Rapid prediction of carbapenemases in Pseudomonas aeruginosa by imipenem/relebactam and MALDI-TOF MS.
The study characterizes various carbapenemase genes such as blaIMP-13, blaIMP-94, blaNDM-1, blaNDM-5, blaNDM-7, blaNDM-23, blaVIM-1, blaVIM-2, blaVIM-20, blaKPC-2, blaKPC-3, blaGES-1, blaGES-5, blaGES-7, blaGES-20, blaPER-1, blaVEB-1, blaCTX-M-15, blaCTX-M-9, blaSHV-12, blaFOX-4, blaCMY-2, blaDHA-1, blaOXA-2, blaOXA-10, blaOXA-14, blaOXA-15, and blaOXA-48 in Pseudomonas aeruginosa using MALDI-TOF MS hydrolysis assays.
Zoonotic potential of uropathogenic Escherichia coli lineages from companion animals.
The study identified several antimicrobial resistance genes in uropathogenic E. coli strains from companion animals, including blaTEM-1b, sul1, sul2, dfrA1_10, dfrA17_1, dfrA1_8, dfrA7_5, gyrA_S83L, tetA, tetB, aph(6)-Id, aph(3'')-Ib, ant(3'')-Ia, blaCTX-M-15, blaTEM-106, blaSHV-102, and blaCMY-2. These genes confer resistance to various antibiotics such as penicillins, sulfonamides, trimethoprim, quinolones, tetracyclines, streptomycin, and cephalosporins.
Stool carriage of CTX-M/CMY-producing Salmonella enterica in a Chinese tertiary hospital in Shenzhen, China.
The study identified bla CTX-M-14, bla CTX-M-55, bla CTX-M-65, and bla CMY-2 as the primary beta-lactamase genes contributing to cefotaxime resistance in Salmonella isolates. These genes were found in various Salmonella serotypes, with bla CTX-M-65 being exclusive to S. 4,[5],12:i:- strains.
Genomic characterization of extended-spectrum beta-lactamase-producing Escherichia coli spread among chickens and healthy residents in Lombok, Indonesia.
The study identifies bla CTX-M-55, bla CTX-M-15, bla CTX-M-1, bla CMY-2, and bla DHA-1 as the most prevalent extended-spectrum beta-lactamase genes in E. coli isolates from chickens and humans in Lombok, Indonesia. Additionally, the study characterizes a 200 kb IncHI1 plasmid carrying multiple resistance genes, including aac(3)-IId, aph(6)-Id, aph(3’’)-Ib, aadA17, mph(A), Inu(F), qnrS1, sul2, and dfrA14, contributing to multidrug resistance.
Extended spectrum beta-lactamase producing Escherichia coli and antimicrobial resistance gene sharing at the interface of human, poultry and environment: results of ESBL tricycle surveillance in Kathmandu, Nepal.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla CTX-M-27, bla CTX-M-14, bla CMY-148, bla CMY-2, bla CMY-4, bla DHA-1, bla OXA-1, bla OXA-9, bla NDM-5, bla TEM-1, bla TEM-135, bla TEM-176, bla TEM-190, and the polymyxin resistance gene mcr-1 in ESBL-producing E. coli isolates from human, poultry, and environmental sources in Kathmandu, Nepal.
Extended spectrum beta-lactamase producing Escherichia coli and antimicrobial resistance gene sharing at the interface of human, poultry and environment: results of ESBL tricycle surveillance in Kathmandu, Nepal.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla CTX-M-27, bla CTX-M-14, bla CMY-148, bla CMY-2, bla CMY-4, bla DHA-1, bla OXA-1, bla OXA-9, bla NDM-5, bla TEM-1, bla TEM-135, bla TEM-176, bla TEM-190, and the polymyxin resistance gene mcr-1 in ESBL-producing E. coli isolates from human, poultry, and environmental sources in Kathmandu, Nepal.
Extended spectrum beta-lactamase producing Escherichia coli and antimicrobial resistance gene sharing at the interface of human, poultry and environment: results of ESBL tricycle surveillance in Kathmandu, Nepal.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla CTX-M-27, bla CTX-M-14, bla CMY-148, bla CMY-2, bla CMY-4, bla DHA-1, bla OXA-1, bla OXA-9, bla NDM-5, bla TEM-1, bla TEM-135, bla TEM-176, bla TEM-190, and the polymyxin resistance gene mcr-1 in ESBL-producing E. coli isolates from human, poultry, and environmental sources in Kathmandu, Nepal.
Providencia pseudovermicola sp. nov.: redefining Providencia vermicola and unveiling multidrug-resistant strains from diabetic foot ulcers in Egypt.
The study identifies multiple multidrug-resistant genes in Providencia pseudovermicola sp. nov., including bla CTX-M-14, bla CMY-6, bla NDM-1, qnrD1, aadA, armA, msrE, mphE, lnuF, rmtC, aac(6')-Ib10, sul1, aph(3')-Ia, qacEΔ1, and dfrA1, highlighting the significance of these genes in conferring resistance to various antibiotics.
Genome-Based Molecular Diversity of Extended-Spectrum beta-lactamase-Producing Escherichia coli From Pigeons in China.
The study identifies multiple extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M, bla TEM, bla OXA, bla LAP, and bla CMY, as well as other antibiotic resistance genes such as mcr-1, mcr-1.1, tet(X4), aadA1, aadA2, aph(6)-Id, aph(3")-Ib, aph(3')-Ia, aph(3')-IIa, aac(3)-IVa, aph(4)-Ia, tet(A), tet(M), sul2, sul3, dfrA14, qnrS1, arr-2, fosA3, cmlA5, floR, mph(A), and lnu(F) in ESBL-producing E. coli isolates from pigeons in China.
Wild Birds as Drivers of Salmonella Braenderup and Multidrug Resistant Bacteria in Wetlands of Northern Italy.
The study identifies several AMR genes in bacterial isolates from wild aquatic birds in Northern Italy, including beta-lactamases (blaTEM, blaCMY-1, blaCMY-2, blaNDM, blaKPC), colistin resistance genes (mcr-2, mcr-3, mcr-4), tetracycline resistance genes (tetA, tetB, tetC, tetL, tetM, tetK), macrolide resistance genes (ermB, vatD, vgA, msrC), vancomycin resistance genes (vanC1, vanC2, vanM, vanG), sulfonamide resistance genes (sul1, sul2, sul3), aminoglycoside resistance genes (aac(3), aac(6')-Ib, aph(3')-Ia, armA, rmtB, rmtC, rmtF), and nitrofurantoin resistance genes (nfsA, nfsB).
ESBL/pAmpC-producing Enterobacterales in common leopard geckos (Eublepharis macularius) and central bearded dragons (Pogona vitticeps) from Portugal.
The study identified ESBL and AmpC beta-lactamase genes, including bla CMY-2, bla CTX-M-15, and bla TEM-1, in 3GC-resistant Enterobacterales from common leopard geckos and central bearded dragons in Portugal.
Whole genome sequencing reveals virulence-mobile element linkages and phylogenetic diversity in multidrug-resistant Escherichia coli from Nigeria.
The study identified multidrug-resistant Escherichia coli isolates from Nigeria, highlighting the presence of virulence genes and mobile genetic elements, along with specific mutations in gyrA and parC that confer resistance to fluoroquinolones.
Interaction of the SXT/R391 element ICEPmiJpn1 with its natural host Proteus mirabilis.
The study identifies the blaCMY-2 gene carried by the ICE Pmi Jpn1, which confers ampicillin resistance in Proteus mirabilis and Escherichia coli.
Phenotypic and Genotypic Characterization of ESBL-, AmpC-, and Carbapenemase-Producing Klebsiella pneumoniae and High-Risk Escherichia coli CC131, with the First Report of ST1193 as a Causative Agent of Urinary Tract Infections in Human Patients in Algeria.
The study identifies several AMR genes, including blaCTX-M-15, blaNDM, blaOXA-48, blaCTX-M-27, and blaCMY-59, in multidrug-resistant E. coli and K. pneumoniae isolates from Algeria. These genes contribute to resistance against various antibiotics, highlighting the need for enhanced surveillance and infection control measures.
Phenotypic and Genotypic Characterization of ESBL-, AmpC-, and Carbapenemase-Producing Klebsiella pneumoniae and High-Risk Escherichia coli CC131, with the First Report of ST1193 as a Causative Agent of Urinary Tract Infections in Human Patients in Algeria.
The study identifies several AMR genes, including blaCTX-M-15, blaNDM, blaOXA-48, blaCTX-M-27, and blaCMY-59, in multidrug-resistant E. coli and K. pneumoniae isolates from Algeria. These genes contribute to resistance against various antibiotics, highlighting the need for enhanced surveillance and infection control measures.
Phenotypic and Genotypic Characterization of ESBL-, AmpC-, and Carbapenemase-Producing Klebsiella pneumoniae and High-Risk Escherichia coli CC131, with the First Report of ST1193 as a Causative Agent of Urinary Tract Infections in Human Patients in Algeria.
Phenotypic and Genotypic Characterization of ESBL-, AmpC-, and Carbapenemase-Producing Klebsiella pneumoniae and High-Risk Escherichia coli CC131, with the First Report of ST1193 as a Causative Agent of Urinary Tract Infections in Human Patients in Algeria.
OXA-204 Carbapenemase in Clinical Isolate of Pseudomonas guariconensis, Tunisia.
The study reports the isolation of a Pseudomonas guariconensis clinical isolate producing OXA-204 carbapenemase, highlighting the spread of OXA-48-like genes beyond Enterobacterales. The isolate exhibited resistance to multiple antibiotics due to the presence of various resistance genes, including blaOXA-204, blaCMY-16, blaDHA-1, and others.
Broadly reactive monoclonal antibodies against beta-lactamases for immunodetection of bacterial resistance to antibiotics.
The study describes broadly reactive monoclonal antibodies (MAbs) against AmpC beta-lactamases, which are key enzymes in bacterial resistance to beta-lactam antibiotics. These MAbs recognize a conserved epitope of 11 amino acids and show cross-reactivity with various AmpC beta-lactamases, including DHA-1, CMY-34, ACT-14, PDC-195, and ADC-144.
Resistance Profiling of Predominant Non-E. coli Enterobacteriaceae Isolated From Humans, Food Animals, and the Environment in the Fako Division of Cameroon.
The study identified PMQR genes (acrA, acrB, aac(6')-ib-cr) and beta-lactamase genes (blaCTX-M-1, blaCMY-2) in non-E. coli Enterobacteriaceae isolates from humans, food animals, and the environment in the Fako Division of Cameroon, indicating widespread antibiotic resistance.
Cooperative resistance varies among beta-lactamases in E. coli, with some enabling cross-protection and sustained extracellular activity.
The study identifies seven beta-lactamase genes (bla ampC, bla TEM-1, bla CTX-M-15, bla CMY-2, bla NDM-5, bla KPC-2, and bla OXA-181) in E. coli that contribute to cooperative resistance, with varying levels of efficacy in rescuing susceptible cells and facilitating cross-protection against β-lactam antibiotics.
Massive culture-based approach for the screening of AmpC, ESBL, and carbapenemase producers from rectal swabs.
The study presents a massive culture-based approach for the screening of AmpC, ESBL, and carbapenemase producers from rectal swabs, demonstrating improved specificity for detecting ESBL producers compared to conventional methods. It identifies various beta-lactamase genes, including bla CTX-M-1/2-like, bla CTX-M-8-like, bla CTX-M-9-like, bla SHV-like, bla TEM-like, bla GES-like, bla MOX, bla CIT, bla DHA, bla ACC, bla EBC, bla FOX, bla CMY-2, and bla NDM.
Prevalence and antimicrobial resistance of Salmonella enterica isolated from cattle farms in Inner Mongolia.
The study identified several AMR genes in Salmonella enterica isolates from Inner Mongolia, including bla TEM-1, cmlA, tetA, tetB, tetM, aadA2, aph(3')-IIa, aacC4, aac(3)-IIa, sul1, sul3, oqxA, and oqxB, which confer resistance to beta-lactams, chloramphenicol, tetracyclines, aminoglycosides, sulfonamides, and quinolones.
Molecular characterization of multidrug-resistant and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolated from Sonali chicken meat in Bangladesh.
The study identified several beta-lactam resistance genes, including blaTEM, blaCTX-M-2a, blaOXA-1, blaCMY, and blaNDM-1, in multidrug-resistant and ESBL-producing E. coli isolates from Sonali chicken meat in Bangladesh.
On the Difficulty to Detect Carbapenem Resistance in the Environment: Characterisation of Escherichia coli With Reduced Carbapenem Susceptibility Isolated in a French River.
The Microbiological Characteristics and Genomic Surveillance of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Clinical Samples.
The study identified multiple carbapenemase genes, including bla NDM-5, bla NDM-1, and bla OXA-232, as well as extended-spectrum beta-lactamases like bla CTX-M-15. Mutations in porin genes ompK36 and ompK37, and regulatory genes acrR and ramR, were associated with reduced susceptibility to carbapenems, cephalosporins, fluoroquinolones, and tigecycline.
Genomic characterization of a multidrug-resistant Citrobacter portucalensis isolate co-harboring bla (KPC-2) and bla (NDM-1) on distinct plasmids.
The study identifies a multidrug-resistant Citrobacter portucalensis isolate co-harboring bla KPC-2 and bla NDM-1 on distinct plasmids, along with additional resistance genes on the chromosome and plasmids, highlighting the potential for horizontal gene transfer and the need for enhanced surveillance.
Metagenomic analysis after selective culture enrichment of hospital and community wastewater enhances antimicrobial resistance gene detection.
The study identifies various beta-lactamase genes such as bla CTX-M, bla KPC, bla NDM, and bla VIM, along with other resistance genes like erm(TR), lsa, efrA, efrB, and optrA, which were detected through selective culture enrichment of wastewater samples.
Monitoring, surveillance, antimicrobial resistance and genetic diversity analysis of non-typhoidal Salmonella in South Africa from 1960-2023 from animal and animal products.
The study identified several AMR genes in Salmonella isolates from South Africa, including blaPSE, blaSHV, qnrS, tetA, qnrA, cat1, blaCMY-2, and qnrB, which were associated with resistance to various antibiotics such as ceftriaxone, chloramphenicol, tetracycline, and others.
Fecal carriage of resistant Escherichia coli in livestock in Algeria: emergence of NDM and OXA-181.
The study identified the presence of 3GC-resistant E. coli in livestock in Algeria, with the detection of various resistance genes including bla CTX-M, bla NDM-1, bla OXA-181, bla CMY, tet A, aac(6')-Ib, and intI1. These genes contribute to resistance against multiple antibiotics, highlighting the need for monitoring and control strategies.
Prevalence and genetic characteristics of antimicrobial-resistant Escherichia coli in wild birds in Japan.
The study identified several AMR genes and mutations in E. coli isolates from wild birds in Japan, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla MOX-4, bla CMY-2, qnrS1, qnrS2, and mutations in gyrA and parC that confer resistance to cefotaxime, nalidixic acid, and ciprofloxacin.
Antibiotic resistance in white stork cloaca and environmental samples
The study identified various antibiotic resistance genes in bacterial isolates from white stork cloaca and environmental samples, highlighting the presence of resistance mechanisms against beta-lactams, aminoglycosides, quinolones, and polymyxins.
Resistance, virulence and genetic diversity of Salmonella Typhimurium in South Africa (1999-2021).
The study identified several AMR genes in Salmonella Typhimurium isolates from South Africa, including beta-lactamases (bla PSE, bla CMY-2, bla TEM, bla SHV), sulfonamide resistance genes (sul1, sul2, sul3), fluoroquinolone resistance genes (qnrA, qnrB, qnrS), tetracycline resistance genes (tetA, tetB), and trimethoprim resistance genes (dfrXI, dfrXII).
No evidence of multidrug-resistant Enterobacterales transmission between healthy companion animals and pet owners in the greater Atlanta area: a pilot study.
The study identified several AMR genes and mutations in E. coli isolates from both humans and pets, including blaCMY-2, blaCTX-M-15, blaTEM-1B, and mutations in gyrA and parC. These findings highlight the presence of multidrug-resistant Enterobacterales in healthy individuals and their companion animals.
Rapid detection of gram-negative antimicrobial resistance determinants directly from positive blood culture broths using a multiplex PCR system.
The study evaluated the BIOFIRE FILMARRAY Antimicrobial Resistance (AMR) Panel for rapid detection of AMR genes in gram-negative bacteria from positive blood culture broths. It identified several AMR genes, including beta-lactamases (TEM-1, SHV-1, CTX-M, KPC, NDM, OXA-1, OXA-23), AmpC beta-lactamases (CMY/MOX, DHA), aminoglycoside modifying enzymes (AAC(6′)-Ib-cr), and fluoroquinolone resistance mutations (ParC-S80I, GyrA-S83F/I/L).
A multi-isolate genomic approach identifies diverse Escherichia coli contamination and antimicrobial resistance carriage on retail foods.
The study identified various AMR genes in E. coli isolates from retail foods, including beta-lactamases (blaCMY-2, blaCTX-M-27, blaCTX-M-55) and the macrolide resistance gene erm(42).
Molecular characterization of extended spectrum beta lactamase producing Escherichia coli in two different wastewater treatment plants in Hatay Province, Türkiye.
The study identified several extended spectrum beta lactamase (ESBL) genes, including bla CTX-M, bla CTX-M-15, bla CTX-M-55, bla CTX-M-1, bla CTX-M-3, bla TEM, and bla CMY-2, in ESBL-producing Escherichia coli isolates from wastewater treatment plants in Hatay Province, Türkiye. Additionally, quinolone resistance genes such as aac(6)-Ib, qnrA, and qnrB, and disinfectant resistance genes like qacEΔ1, ydgE, ydgF, mdfA, emrE, sugE(c), and sugE(p) were also detected.
Pathogenic potential of amoxicillin-clavulanic acid resistant Klebsiella pneumoniae isolated from aquatic environment: a study of multidrug resistance and virulence.
The study identified several AMR genes in AMC-resistant K. pneumoniae isolates from aquatic environments, including bla TEM, bla SHV, bla CTX-M, bla NDM, bla OXA-48, bla CMY, qnr S, qnr B, tet A, tet B, sul 1, dfr A12, intl 1, intl 2, mrk D, ecp A, and iuc C. These genes were associated with resistance to multiple antibiotics, highlighting the complex resistance profiles of these isolates.
Analysis of avian pathogenic Escherichia Coli (APEC) and its antimicrobial resistance risk characteristics and critical control points in laying hens.
The study identified several AMR genes in APEC isolates, including tet(A), floR, sul2, aph(3')-Ib, aph(6)-Id, bla TEM-1B, qnrS1, bla CTX-M-55, dfrA14, and mph(A), which contribute to resistance against tetracyclines, florfenicol, sulfonamides, aminoglycosides, beta-lactams, fluoroquinolones, and macrolides.
Isolation and characterization of Salmonella enterica serovars from poultry in Egypt: a comprehensive genetic analysis of ESBLs, MCR, integron and other resistance genes.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from poultry in Egypt, including bla TEM, bla SHV, bla CTX-M, bla OXA-10, bla CMY-2, mcr-1, and intI 1. These genes were associated with resistance to various antibiotics, highlighting the presence of multidrug-resistant strains.
Genomic characterisation of multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from various sources in Algeria, North Africa.
The study identified multiple AMR genes and chromosomal mutations in multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from Algeria, including bla TEM-1B, bla CTX-M-15, aac(3)-Id, aadA7, sul1, tet(A), mph(A), qnrB19, cmlA1, and floR, along with mutations in gyrA and parC genes that confer resistance to ciprofloxacin.
Genomic characterisation of multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from various sources in Algeria, North Africa.
The study identified multiple AMR genes and chromosomal mutations in multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from Algeria, including bla TEM-1B, bla CTX-M-15, aac(3)-Id, aadA7, sul1, tet(A), mph(A), qnrB19, cmlA1, and floR, along with mutations in gyrA and parC genes that confer resistance to ciprofloxacin.
Ultrasound-Assisted Extraction: Unlocking the Antibacterial Potential of Coptis chinensis Franch. Against ESBL-Producing Enterobacterales.
The study identifies multiple beta-lactamase resistance genes in ESBL-PE strains, including blaCTX-M-14, blaCTX-M-1, blaCTX-M-3, blaCTX-M-15, blaCTX-M-65, blaSHV, blaTEM, blaEC, blaACC, blaCMY, blaACT, blaDHA, and efflux pump genes such as acrF, emrD, mdtM, silA, kdeA, oqxA, oqxB, arsB, oqxA10, oqxB5, oqxB19, arsA, and hugA, which contribute to multidrug resistance in these isolates.
Molecular Characterization of KPC-2 and CMY AmpC Beta Lactamases in Ceftazidime-Avibactam Resistant Klebsiella pneumoniae in a Tertiary Care Hospital.
Plasmid-mediated CMY AmpC beta-lactamase was identified as the primary mechanism of ceftazidime-avibactam resistance in Klebsiella pneumoniae, while bla KPC-2 was not detected.
Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock.
The study identified multiple AMR genes in Citrobacter freundii isolates from Egyptian livestock, including bla TEM, bla CTX-M, bla OXA-10, bla CMY-2, qnrA, aadA1, sul2, dfrA1, ermB, tet(M), int1, and mcr-1, which confer resistance to various antibiotics.
Genomic diversity and antimicrobial resistance of Vibrio cholerae isolates from Africa: a PulseNet Africa initiative using nanopore sequencing to enhance genomic surveillance.
The study identified a high prevalence of trimethoprim resistance genes (dfrA1, dfrA15, dfrA31) and other resistance genes such as floR, strA, strB, varG, blaCARB-2, aadA1, aadA2, sul1, sul2, catB9, tet(C), tet(G), tet(59), qacEdelta, and blaCMY-4 in Vibrio cholerae isolates from Africa. Fluoroquinolone resistance mutations (gyrA_S83I and parC_S85L) and nitrofuran resistance mutations (nfsA_R169C and nfsB_Q5*) were also prevalent.
PanARGMiner (Pan-Genomic Antimicrobial Resistance Gene Miner): An advanced feature selection framework for extracting key resistance genes from pan-genomic datasets.
PanARGMiner effectively identifies key resistance genes from pan-genomic datasets, including both known and novel AMR genes, across multiple bacterial species.
A Monitoring Method to Evaluate the Accumulation of Antimicrobial-Resistance Genes in Gram-Negative Bacteria Distributed in Environmental Water.
The study identified multiple antimicrobial resistance genes (ARGs) in Gram-negative bacteria isolated from environmental water samples, including bla NDM-5, bla CTX-M-27, bla DHA-1, and others, indicating the presence of carbapenem-resistant and extended-spectrum beta-lactamase-producing bacteria in the Vietnamese VAC ecosystem.
Contrasting pH optima of beta-lactamases CTX-M and CMY influence Escherichia coli fitness and resistance ecology.
The study identifies CTX-M-15 and CMY-2 beta-lactamases as key contributors to pH-dependent resistance in E. coli, demonstrating that their activity and resistance profiles are significantly influenced by environmental pH conditions.
Changing dynamics of antibiotic resistant Escherichia in Caspian gulls shows the importance of longitudinal environmental studies
The study identifies specific AMR genes such as bla CMY-2 and bla CTX-M-1, as well as colicin genes cib and cba, which play roles in the persistence and competitive success of resistant E. coli strains in Caspian gulls.
Analysis of the Concordance Between the Use of Phenotypic Screening Tests with the β-Lactamase Gene Profile in Selected Gram-Negative Bacteria.
The study identified several β-lactamase genes, including NDM, KPC, OXA-48, TEM, SHV, CTX-M-15, OXA-24/40, OXA-51, CMY-2, and DHA, which are associated with resistance to carbapenems and β-lactam antibiotics in Gram-negative bacteria.
In vivo selection of CMY-219 conferring resistance to ceftazidime-avibactam in an OXA-484-producing E. coli ST410.
Cloning and sequence analysis of blaBIL-1, a plasmid-mediated class C beta-lactamase gene in Escherichia coli BS.
Cloning and sequence analysis of blaBIL-1, a plasmid-mediated class C beta-lactamase gene in Escherichia coli BS.
Cloning and sequence analysis of blaBIL-1, a plasmid-mediated class C beta-lactamase gene in Escherichia coli BS.
Cloning and sequence analysis of blaBIL-1, a plasmid-mediated class C beta-lactamase gene in Escherichia coli BS.
Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance.
Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance.
Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance.
Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance.
A plasmid-mediated CMY-2 beta-lactamase from an Algerian clinical isolate of Salmonella senftenberg.
Chromosomally Encoded AmpC-Type beta-lactamase in a Clinical Isolate of Proteus mirabilis.
The study identifies a chromosomally encoded AmpC-type beta-lactamase, designated CMY-3, in a clinical isolate of Proteus mirabilis. This enzyme confers resistance to various β-lactam antibiotics, including amoxicillin, ticarcillin, cephalothin, cefoxitin, cefotaxime, ceftazidime, and aztreonam.
Transferable class C beta-lactamases in Escherichia coli strains isolated in Greek hospitals and characterization of two enzyme variants (LAT-3 and LAT-4) closely related to Citrobacter freundii AmpC beta-lactamase.
Transferable class C beta-lactamases in Escherichia coli strains isolated in Greek hospitals and characterization of two enzyme variants (LAT-3 and LAT-4) closely related to Citrobacter freundii AmpC beta-lactamase.
Transferable class C beta-lactamases in Escherichia coli strains isolated in Greek hospitals and characterization of two enzyme variants (LAT-3 and LAT-4) closely related to Citrobacter freundii AmpC beta-lactamase.
Characterisation of CMY-4, an AmpC-type plasmid-mediated beta-lactamase in a Tunisian clinical isolate of Proteus mirabilis.
Characterisation of CMY-4, an AmpC-type plasmid-mediated beta-lactamase in a Tunisian clinical isolate of Proteus mirabilis.
Characterisation of CMY-4, an AmpC-type plasmid-mediated beta-lactamase in a Tunisian clinical isolate of Proteus mirabilis.
Characterisation of CMY-4, an AmpC-type plasmid-mediated beta-lactamase in a Tunisian clinical isolate of Proteus mirabilis.
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