blaCTX-M-14

β-lactamase

Overview

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
N106S	-	-	Escherichia coli	cefoxitin\|cephalosporins	Reslit	Candidate
D240G	-	-	Escherichia coli	cefoxitin\|cephalosporins	Reslit	Candidate

Papers1

Synergistic effects of functionally distinct substitutions in β-lactamase variants shed light on the evolution of bacterial drug resistance.

Both mutations are functionally distinct and synergistically affect resistance levels.

Protein Change: N106S, D240G
Organisms: Escherichia coli
Confers Resistance To: cefoxitin|cephalosporins
Validation Method: X-ray crystallography and kinetic analysis; kinetic analysis and X-ray crystallography
Source Database: Reslit