Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaDES-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ampicillin, amoxicillin +5 | Desulfovibrio desulfuricans +1 | - | 2002 | AF426161 | AAM45855.1 |
| blaD | Reslit | 6 | penicillin, cephalosporins +4 | Bacillus pumilus +10 | Alaska|USA, India|Malaysia|South China | 2016, 2018, 2020, 2021, 2022, 2024 | ABV63006|CP002207.1|YP003975776.1|ELS62907.1|NP388091.1 | - |
Biochemical-Genetic Analysis and Distribution of DES-1, an Ambler Class A Extended-Spectrum beta-lactamase from Desulfovibrio desulfuricans.
The study identifies DES-1, a novel Ambler class A extended-spectrum beta-lactamase from Desulfovibrio desulfuricans, which confers resistance to various β-lactam antibiotics including ampicillin, amoxicillin, ticarcillin, cefotaxime, ceftriaxone, and cefoperazone.
Biochemical-genetic analysis and distribution of DES-1, an Ambler class A extended-spectrum beta-lactamase from Desulfovibrio desulfuricans.
Biochemical-genetic analysis and distribution of DES-1, an Ambler class A extended-spectrum beta-lactamase from Desulfovibrio desulfuricans.
Biochemical-genetic analysis and distribution of DES-1, an Ambler class A extended-spectrum beta-lactamase from Desulfovibrio desulfuricans.
Biochemical-genetic analysis and distribution of DES-1, an Ambler class A extended-spectrum beta-lactamase from Desulfovibrio desulfuricans.
Class D beta-lactamases do exist in Gram-positive bacteria.
The study identifies and characterizes class D beta-lactamases in Gram-positive bacteria, demonstrating their ability to confer resistance to various β-lactam antibiotics.
Genomic analysis of bifunctional Class C-Class D beta-lactamases in environmental bacteria.
The study reports the identification of bifunctional Class C-Class D beta-lactamases in environmental bacteria, highlighting their potential for broad-spectrum β-lactam resistance and suggesting possible horizontal gene transfer to clinically relevant bacteria.
A surface loop modulates activity of the Bacillus class D beta-lactamases.
The study identifies that the class D beta-lactamases from Bacillus, specifically BSU-2 and BAT-2, have low catalytic activity due to an elongated loop1. Deleting three amino acid residues (RLT) in this loop significantly enhances their activity against ampicillin and ticarcillin.
Foodborne Pathogenic Vibrios: Antimicrobial Resistance.
The paper discusses the presence of various antibiotic resistance genes in Vibrio species, including strB, sul2, tetA, blaTEM, qnrA, ermB, floR, aac(3)-IIa, blaNDM-1, blaCMY, blaP1, catB3, and others, which confer resistance to antibiotics such as streptomycin, sulfamethoxazole, tetracycline, ampicillin, fluoroquinolones, erythromycin, florfenicol, gentamicin, carbapenems, chloramphenicol, and trimethoprim.
ROCker Models for Reliable Detection and Typing of Short-Read Sequences Carrying beta-lactamase Genes.
The study presents ROCker models for the reliable detection and typing of beta-lactamase genes in short-read metagenomic data, demonstrating superior performance compared to existing methods.
Potential involvement of beta-lactamase homologous proteins in resistance to beta-lactam antibiotics in gram-negative bacteria of the ESKAPEE group.
The study identifies and characterizes beta-lactamase homologous proteins in gram-negative bacteria of the ESKAPEE group, highlighting their potential role in resistance to beta-lactam antibiotics.
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