Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
class C beta-lactamase DHA-10
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaDHA-10 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Morganella morganii | - | - | KP050490.1 | AJO16043.1 |
| blaDHA-12 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Proteus mirabilis +5 | Australia|Singapore|Turkey | 2021 | HG798963.1 | CDL68900.1 |
| blaDHA-13 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Morganella morganii | - | - | KM087855.1 | AIT76108.1 |
| blaDHA-14 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Morganella morganii | - | - | KM087854.1 | AIT76107.1 |
| blaDHA-16 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, CEPHALOSPORIN +15 | Morganella morganii +5 | France, Australia|Singapore|Turkey | 2017, 2021 | KM087852.1 | AIT76105.1 |
| blaDHA-17 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | TICARCILLIN, CEPHALOSPORIN +14 | Morganella morganii +5 | France, Australia|Singapore|Turkey, China | 2017, 2021, 2022, 2024 | KM087850.1 | AIT76103.1 |
| blaDHA-18 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Morganella morganii +4 | Australia|Singapore|Turkey | 2021 | KM087841.1 | AIT76094.1 |
| blaDHA-19 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Morganella morganii | - | - | KM087849.1 | AIT76102.1 |
| blaDHA-20 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +11 | Citrobacter koseri +5 | Australia|Singapore|Turkey | 2021 | KM087848.1 | AIT76101.1 |
| blaDHA-21 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Morganella morganii | - | 1997 | KM087847.1 | AIT76100.1 |
| blaDHA-22 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | KM087856.1 | AIT76109.1 |
| blaDHA-24 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, CEPHALOSPORIN +12 | Klebsiella oxytoca +1 | South Africa | 2023 | KU759569.1 | AMM39807.1 |
| blaDHA-25 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Klebsiella pneumoniae | - | - | KY563770.1 | AQM40192.1 |
| blaDHA-26 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Klebsiella pneumoniae | - | - | MH067966.1 | AVP74341.1 |
| blaDHA-27 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Escherichia coli | - | - | MH067965.1 | AVP74340.1 |
| blaDHA-28 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Morganella morganii | - | - | MK088090.1 | AZB74599.1 |
| blaDHA-29 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Citrobacter freundii | - | - | MN219696.1 | QDY98373.1 |
| blaDHA-30 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Morganella morganii subsp. sibonii | - | - | LC773167.1 | BEK76843.1 |
| blaDHA-31 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Morganella morganii | - | - | OR398192.1 | WLO97155.1 |
| blaDHA-32 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Morganella morganii | - | - | OR438753.1 | WLY62595.1 |
| blaDHA-33 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Escherichia coli | - | - | OR715113.1 | WOL30716.1 |
| blaDHA-34 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Escherichia coli | - | - | PQ394546.1 | XHO32889.1 |
| blaDHA-35 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Proteus mirabilis | - | - | PV075209.1 | XOU30673.1 |
| blaDHA-36 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Morganella morganii | - | - | PV075210.1 | XOU30674.1 |
| blaDHA-37 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Morganella morganii | - | - | PV075211.1 | XOU30675.1 |
| blaDHA-38 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Escherichia coli | - | - | PV700363.1 | XUZ93895.1 |
| blaDHA-4 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOSPORIN +10 | Morganella morganii | - | - | CP026046.1 | AUT98902.1 |
| blaDHA-5 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Morganella morganii | - | - | JF273491.1 | AEL22919.1 |
| blaDHA-9 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOSPORIN +10 | Morganella morganii | - | - | KJ207201.1 | AHL39320.1 |
| blaDHA-23 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | cefoxitin, cefotaxime +13 | Klebsiella pneumoniae +1 | Northern Taiwan | 2015 | NG_049069.1 | WP_063860108.1 |
| blaMOR-2 | Card DatabaseReference Gene CatalogResFinder Database | 5 | CEPHALOSPORIN, AMOXICILLIN +4 | Morganella morganii | - | 2021 | NG_049310.1 | WP_063860842.1 |
| blaDHA-2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +12 | Klebsiella pneumoniae +1 | Mexico|Mexico City | 2001, 2023 | AF259520.1 | AAG36927.1 |
| blaDHA-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 149 | ceftazidime, cefotaxime +33 | Klebsiella pneumoniae +50 | Taiwan, United States, South Korea, England|Wales, Parisian region, Korea, China, Eastern Europe|India|Latin America|Asia Pacific|North America|Western Europe, Spain, South China, India, Europe, Portugal, Netherlands, France, Algeria, Nepal, USA, Austria|Germany, Japan, Iran, Guangzhou, China|Guangzhou, Shanghai, China, Singapore|Turkey, Norway|Asia, Cambodia, Sri Lanka|Switzerland, Italy, Australia|United States, Philippines|Texas, United Kingdom, Europe|Netherlands, Jakarta, Vietnam, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, India|Pakistan|Bangladesh|Philippines|Democratic Republic of the Congo, California|Europe|North America|Republic of Congo, Kanto Region, Japan, India|Ghana|Nepal|Laos, France|Switzerland, Senegal, Philippines, Bulgaria, Ghana, Gulf Cooperation Council (GCC) region|Gulf Cooperation Council region, Yangzhou, China, China|Guangzhou, China, Europe|Asia|North America|Western and South-Eastern Asia, Czech Republic, Valencia, Spain, Poland, Mexico|Mexico City, South Africa, Germany, Australia, Henan|Shaanxi, Bangladesh|Brazil|Greece|Italy|Kenya|South Africa|Thailand|Uganda|Vietnam, Accra, Ghana|Ghana, Bangladesh, Tunisia, Malaysia, Bulgaria|Europe, Russia, Southeast Asia, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, mid-Atlantic United States, Europe|Italy, Indonesia, Kathmandu, Nepal, Oman, Europe|United States, Singapore, Australia|France|Bangladesh|United States, Normandy|France, Europe|China, Saudi Arabia | 1998, 2002, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AF055067|X77455|X91840|U58495|X04730 | CAA76196.1 |
| blaDHA-3 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | cefotaxime, ceftazidime +13 | Klebsiella pneumoniae +1 | Taiwan | 2005 | AY494945 | AAR87489.1 |
| blaDHA | Reslit | 55 | cephalosporins, ampicillin +13 | Klebsiella oxytoca +27 | United States, Europe, Germany, China, Amsterdam, the Netherlands, Southern Taiwan, Malaysia, Libya, Mozambique, Mexico City, Asia|Latin America|Africa, Thailand, Portugal, Australia, Taiwan|Taipei, Taiwan, South Korea, Bangladesh, Iran, Italy, Japan, Egypt, France, China|global, Western Province of Sri Lanka, India, Shanxi Province|Shanxi Province, China, Assam, India, Taiwan, South Korea|Gwangju A–C|Yeoju D, Southern Thailand, Brazil, Calgary, Canada|Calgary, Alberta, Canada, Russia, China|Thailand|USA|Spain|Norway|Japan|Vietnam|Hong Kong | 2006, 2008, 2009, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AF313472|X75562|AY008291|AF300985|Z21956|Z49084|Z30178|AF427133|AF227204|X77455 | - |
| bla(DHA-1) | Reslit | 2 | cefoxitin, cefotaxime +3 | Klebsiella pneumoniae +1 | Kinki region of Japan|Japan, India | 2010, 2017 | - | - |
| DHA | Reslit | 16 | cefoxitin, cefotaxime +6 | Escherichia coli +15 | Taiwan, Iran, Delhi, India, Italy, Tanzania|Thailand|human|swine, Upper Egypt, Europe, Bahrain, Egypt, China, Japan, Ho Chi Minh City, Vietnam, New York City | 2012, 2015, 2017, 2019, 2020, 2021, 2022, 2023, 2025 | KY706079|KY706080|KY753816 | - |
| blaDHA-6 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOSPORIN +14 | Escherichia coli +1 | Spain | 2013, 2014 | HQ322612.1 | ADT91161.1 |
| blaDHA-7 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | TICARCILLIN, CEPHALOSPORIN +17 | Enterobacter cloacae +3 | Spain, Mexico|Mexico City, South Africa, India | 2013, 2014, 2023, 2024 | HQ456945.1 | ADQ00385.1 |
| dha | Reslit | 1 | cephalosporins | Enterobacteriaceae | Germany | 2015 | - | - |
| blaDHA–3 | Reslit | 1 | cefoxitin, ceftriaxone +1 | Klebsiella pneumoniae | China | 2020 | CP051490|CP051491|CP051492 | - |
| blaDHA–1 | Reslit | 2 | cephalosporins, ampicillin +7 | Klebsiella pneumoniae +1 | China | 2021, 2022 | CP040833|CP040834|CP040835|CP040836|CP040837|CP040838|CP040839 | - |
| bla(DHA) | Reslit | 1 | cefoxitin | Escherichia coli | Switzerland | 2023 | PRJNA931234|PRJNA931814 | - |
| blaDHA-15 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | cephalosporins, TICARCILLIN +11 | Citrobacter freundii +1 | France | 2023, 2024 | NG_049060|OW969688|MK047608 | AIT76106.1 |
| bla_DHA-1 | Reslit | 2 | aztreonam, cephalosporins | Klebsiella pneumoniae +1 | China, Tianjin|Southern Karnataka | 2024, 2025 | CP089987.1|CP089991.1|PRJNA787439 | - |
Plasmid-mediated and inducible cephalosporinase DHA-2 from Klebsiella pneumoniae.
Plasmid-mediated and inducible cephalosporinase DHA-2 from Klebsiella pneumoniae.
Plasmid-mediated and inducible cephalosporinase DHA-2 from Klebsiella pneumoniae.
Plasmid-mediated and inducible cephalosporinase DHA-2 from Klebsiella pneumoniae.
Emergence of Klebsiella pneumoniae isolates producing inducible DHA-1 beta-lactamase in a university hospital in Taiwan.
The study identifies the emergence of Klebsiella pneumoniae isolates producing inducible DHA-1 beta-lactamase, which confers resistance to ceftazidime, cefotaxime, and aztreonam.
Occurrence of newer beta-lactamases in Klebsiella pneumoniae isolates from 24 U.S. hospitals.
The study identified several beta-lactamases, including bla DHA-1, bla ACT-1, bla FOX-5, bla CMY-2, and bla KPC-2, in Klebsiella pneumoniae isolates from 24 U.S. hospitals. These enzymes confer resistance to various beta-lactam antibiotics.
Epidemiology and clinical features of bloodstream infections caused by AmpC-type-beta-lactamase-producing Klebsiella pneumoniae.
The study identifies DHA-1 and CMY-1 beta-lactamase genes as major contributors to AmpC-type beta-lactamase production in Klebsiella pneumoniae, leading to resistance against extended-spectrum cephalosporins and carbapenems.
Characterization of AmpC-mediated resistance in clinical Salmonella isolates recovered from humans during the period 1992 to 2003 in England and Wales.
The study identified bla DHA-1, bla CMY-2, and bla CMY-4 genes in Salmonella isolates, which confer resistance to various β-lactam antibiotics. These genes were found in plasmids and were transferable, indicating potential for spread.
Identification of a novel cephalosporinase (DHA-3) in Klebsiella pneumoniae isolated in Taiwan.
A novel cephalosporinase, DHA-3, was identified in a clinical isolate of Klebsiella pneumoniae. The gene was non-self-transferable but could be introduced into E. coli via electrotransformation, leading to resistance against several β-lactam antibiotics.
Identification of a novel cephalosporinase (DHA-3) in Klebsiella pneumoniae isolated in Taiwan.
Identification of a novel cephalosporinase (DHA-3) in Klebsiella pneumoniae isolated in Taiwan.
Identification of a novel cephalosporinase (DHA-3) in Klebsiella pneumoniae isolated in Taiwan.
Identification of a novel cephalosporinase (DHA-3) in Klebsiella pneumoniae isolated in Taiwan.
Emergence of DHA-1-producing Klebsiella spp. in the Parisian region: genetic organization of the ampC and ampR genes originating from Morganella morganii.
The study characterizes the DHA-1 beta-lactamase gene in Klebsiella spp. isolates, highlighting its genetic organization and resistance profile.
Prevalence of newer beta-lactamases in gram-negative clinical isolates collected in the United States from 2001 to 2002.
The study identified various beta-lactamases including SHV, CTX-M, FOX, CMY, DHA, and KPC, which confer resistance to multiple beta-lactam antibiotics in gram-negative clinical isolates in the United States.
Detection of extended-spectrum beta-lactamases by using boronic acid as an AmpC beta-lactamase inhibitor in clinical isolates of Klebsiella spp. and Escherichia coli.
The study evaluates the use of boronic acid as an inhibitor to enhance the detection of extended-spectrum beta-lactamases (ESBLs) in clinical isolates of Klebsiella spp. and Escherichia coli, particularly in cases where ESBLs may be masked by plasmid-mediated AmpC beta-lactamases (pAmpCs).
Multiplex Asymmetric PCR-Based Oligonucleotide Microarray for Detection of Drug Resistance Genes Containing Single Mutations in Enterobacteriaceae
The study developed a multiplex asymmetric PCR-based microarray for detecting drug resistance genes containing single mutations in Enterobacteriaceae, focusing on beta-lactamase genes such as bla SHV, bla TEM, bla CTX-M-3, bla CTX-M-9, bla DHA-1, bla CMY-2, bla MOX-1, bla ACC-1, bla FOX-5, and bla MIR-1. It also identified six point mutations in the bla SHV gene.
Prevalence of plasmid-mediated AmpC beta-lactamases in a Chinese university hospital from 2003 to 2005: first report of CMY-2-Type AmpC beta-lactamase resistance in China.
The study identified the presence of plasmid-mediated AmpC beta-lactamases, specifically blaDHA-1 and blaCMY-2, in clinical isolates of Escherichia coli and Klebsiella spp. in a Chinese university hospital. This is the first report of CMY-2-type AmpC beta-lactamase resistance in China.
First outbreak of multidrug-resistant Klebsiella pneumoniae producing both SHV-12-type extended-spectrum beta-lactamase and DHA-1-type AmpC beta-lactamase at a Korean hospital.
The study reports the first outbreak of multidrug-resistant Klebsiella pneumoniae producing both SHV-12-type extended-spectrum beta-lactamase and DHA-1-type AmpC beta-lactamase in Korea.
Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experience.
The study identifies multiple beta-lactamase genes, including bla CMY-2, bla DHA, bla TEM, bla CTX-M, bla IMP-4, and bla KPC-2, contributing to broad-spectrum beta-lactam resistance in Enterobacteriaceae isolates from a children's hospital.
Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-2, bla CTX-M-5, bla CTX-M-15, bla CTX-M-22, bla CTX-M-28, bla SHV-5, bla SHV-12, bla TEM-1, bla OXA-1, bla OXA-2, bla OXA-5, bla PER-1, bla ACT-1, bla MIR-1, bla CMY-2, bla FOX-1, bla DHA-1, and bla KPC-2, in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates.
Identification of plasmid-mediated AmpC beta-lactamases in Escherichia coli, Klebsiella spp., and proteus species can potentially improve reporting of cephalosporin susceptibility testing results.
The study identifies plasmid-mediated AmpC beta-lactamases in Escherichia coli, Klebsiella spp., and Proteus species, highlighting their role in cephalosporin resistance and the importance of APBA testing for accurate susceptibility reporting.
CTX-M-14 and CTX-M-15 enzymes are the dominant type of extended-spectrum beta-lactamase in clinical isolates of Escherichia coli from Korea.
The study identifies CTX-M-14 and CTX-M-15 as the dominant extended-spectrum beta-lactamases in clinical isolates of Escherichia coli in Korea, along with other CTX-M variants and plasmid-borne AmpC beta-lactamases such as DHA-1, CMY-2, CMY-10, and CMY-11.
Prevalence of acquired AmpC beta-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes at a Spanish hospital from 1999 to 2007.
The study identified several acquired AmpC beta-lactamases, including CMY-2, CMY-25, CMY-27, CMY-40, DHA-1, and ACC-1, in Enterobacteriaceae strains from a Spanish hospital between 1999 and 2007. These enzymes conferred resistance to various beta-lactam antibiotics and other drugs.
Antibiotic Resistance Patterns and Detection of blaDHA-1 in Salmonella Species Isolates from Chicken Farms in South Korea.
The study identified the blaDHA-1 gene in three Salmonella enterica serovar Indiana isolates from chicken farms in South Korea, indicating the presence of a plasmid-mediated AmpC beta-lactamase conferring resistance to cephalosporins.
Laboratory surveillance for prospective plasmid-mediated AmpC beta-lactamases in the Kinki region of Japan.
The study identified plasmid-mediated AmpC beta-lactamases (PABLs) in various Enterobacteriaceae isolates, with CMY-2 being the most prevalent in E. coli, DHA-1 in K. pneumoniae, and MOX-1 in K. oxytoca.
Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC beta-lactamases.
The study characterizes the carbapenem-hydrolyzing activities of five plasmid-borne AmpC beta-lactamases (CMY-2, ACT-1, DHA-1, FOX-1, and ACC-1) and shows that CMY-2, ACT-1, and DHA-1 confer resistance to imipenem, while FOX-1 and ACC-1 do not.
Chromosome-encoded AmpC and CTX-M extended-spectrum beta-lactamases in clinical isolates of Proteus mirabilis from Korea.
The study identifies several extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase genes, including bla CTX-M-14a, bla CTX-M-90, bla CTX-M-15, bla CTX-M-12, bla CTX-M-2, bla CTX-M-14b, bla TEM-52, bla SHV-12, bla CMY-2, and bla DHA-1, in clinical isolates of Proteus mirabilis from Korea. These genes were found to be responsible for resistance to various β-lactam antibiotics.
Plasmid typing and resistance profiling of Escherichia fergusonii and other Enterobacteriaceae isolates from South Korean farm animals.
The study identified TEM-1, CTXM-15, and DHA-1 beta-lactamase genes in various Enterobacteriaceae isolates from South Korean farm animals, highlighting their role in beta-lactam resistance.
Characterization of extended-spectrum beta-lactamase genes found among Escherichia coli isolates from duck and environmental samples obtained on a duck farm.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-105, bla CTX-M-27, bla CTX-M-55, bla CTX-M-24e, and others, in Escherichia coli isolates from ducks and environmental samples. These genes confer resistance to various β-lactam antibiotics and other antimicrobials.
Third-generation cephalosporin-resistant Vibrio cholerae, India.
The study reports the isolation of a third-generation cephalosporin-resistant Vibrio cholerae strain carrying the blaDHA-1 and blaNDM-1 genes, which confer resistance to ceftriaxone and carbapenems respectively.
Detection of Amp C genes encoding for beta-lactamases in Escherichia coli and Klebsiella pneumoniae.
The study detected Amp C genes in 29.87% of the study isolates, with the majority co-producing ESBL. The most common Amp C was the CIT family.
Increased frequency of integrons and beta-lactamase-coding genes among extraintestinal Escherichia coli isolated with a 7-year interval.
The study identified an increase in the frequency of integrons and beta-lactamase-coding genes, particularly bla CTX-M-1, bla CTX-M-3, bla CTX-M-15, bla CTX-M-55, bla TEM-1, bla OXA-1, bla SHV-1, bla SHV-12, bla CMY-15, and bla DHA, in extraintestinal Escherichia coli strains isolated over a 7-year period.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.
AmpC beta-lactamases in nosocomial isolates of Klebsiella pneumoniae from India.
The study identified 12 CMY-2 and 8 DHA-1 types of plasmid-mediated AmpC beta-lactamases in Klebsiella pneumoniae isolates from India, highlighting their prevalence and significance in antibiotic resistance.
Epidemiology and resistance mechanisms to imipenem in Klebsiella pneumoniae: a multicenter study.
The study identified KPC-2 carbapenemase, blaCTX-M-9 ESBL, and blaDHA-1 cephalosporinase as the primary resistance mechanisms in imipenem-resistant Klebsiella pneumoniae isolates, leading to multidrug resistance.
First characterisation of plasmid-mediated quinolone resistance-qnrS1 co-expressed blaCTX-M-15 and blaDHA-1 genes in clinical strain of Morganella morganii recovered from a Tunisian Intensive Care Unit.
Genome Sequence of Klebsiella pneumoniae KpQ3, a DHA-1 beta-lactamase-Producing Nosocomial Isolate.
The genome of Klebsiella pneumoniae KpQ3 was sequenced, revealing the presence of the plasmid-mediated DHA-1 beta-lactamase gene and the QnrB4 quinolone resistance determinant.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
An Increase in the clinical isolation of acquired AmpC beta-lactamase-producing Klebsiella pneumoniae in Korea from 2007 to 2010.
The study identified an increase in the clinical isolation of acquired AmpC beta-lactamase-producing Klebsiella pneumoniae in Korea from 2007 to 2010, with blaDHA-1 and blaCMY-2 being the predominant AmpC enzymes. These genes conferred resistance to several β-lactam antibiotics.
Long-term dissemination of acquired AmpC beta-lactamases among Klebsiella spp. and Escherichia coli in Portuguese clinical settings.
The study identifies the long-term dissemination of acquired AmpC beta-lactamases, particularly DHA-1 and CMY-2, among Klebsiella spp. and Escherichia coli in Portuguese clinical settings.
Single or in combination antimicrobial resistance mechanisms of Klebsiella pneumoniae contribute to varied susceptibility to different carbapenems.
The study identified that blaCTX-M-15, blaSHV-12, blaDHA-1, ampR, blaKPC-2, and blaNDM-1 are responsible for carbapenem resistance in Klebsiella pneumoniae. The loss of porins OmpK35 and OmpK36 combined with these genes contributed to resistance against various carbapenems.
Carbapenem and cefoxitin resistance of Klebsiella pneumoniae strains associated with porin OmpK36 loss and DHA-1 β-lactamase production.
Updated molecular epidemiology of carbapenem-non-susceptible Escherichia coli in Taiwan: first identification of KPC-2 or NDM-1-producing E. coli in Taiwan.
The study identifies the first occurrence of KPC-2 and NDM-1 producing E. coli in Taiwan, highlighting the emergence of these carbapenemases as significant contributors to carbapenem resistance. The main resistance mechanism involves plasmidic AmpC beta-lactamases (CMY-2 and DHA-1) in combination with loss of outer membrane porins OmpC and OmpF.
Clinical and microbiological characteristics of tigecycline non-susceptible Klebsiella pneumoniae bacteremia in Taiwan.
The study identified bla CTX-M, bla SHV, and bla DHA-1 genes as responsible for tigecycline non-susceptibility in Klebsiella pneumoniae isolates, contributing to resistance against various beta-lactam antibiotics.
Detection and occurrence of plasmid-mediated AmpC in highly resistant gram-negative rods.
The study identified 13 pAmpC-producing Enterobacteriaceae isolates, including 9 CMY-2, 3 DHA-1, and 1 ACC-1 type in E. coli isolates. The prevalence of pAmpC was found to be 2.6% among group I Enterobacteriaceae.
Phenotypic and molecular characterization of multidrug resistant Klebsiella pneumoniae isolated from a university teaching hospital, China.
The study identified multiple AMR genes in multidrug-resistant Klebsiella pneumoniae isolates, including bla TEM, bla CTX-M, bla DHA, and bla KPC, which contribute to resistance against various antibiotics.
IncH-type plasmid harboring bla CTX-M-15, bla DHA-1, and qnrB4 genes recovered from animal isolates.
The study identified an IncH-type plasmid carrying the blaCTX-M-15, blaDHA-1, and qnrB4 genes in animal-derived Klebsiella pneumoniae isolates, highlighting the potential for horizontal gene transfer of these resistance mechanisms.
Genetic and kinetic characterization of the novel AmpC beta-lactamases DHA-6 and DHA-7.
The study describes the genetic and kinetic characterization of the novel AmpC beta-lactamases DHA-6 and DHA-7, highlighting their resistance mechanisms against various β-lactam antibiotics.
Genetic and kinetic characterization of the novel AmpC beta-lactamases DHA-6 and DHA-7.
The study describes the genetic and kinetic characterization of the novel AmpC beta-lactamases DHA-6 and DHA-7, highlighting their resistance mechanisms against various β-lactam antibiotics.
Plasmid-mediated AmpC: prevalence in community-acquired isolates in Amsterdam, the Netherlands, and risk factors for carriage.
The study identified 7 pAmpC-positive E. coli isolates, including 6 blaCMY-2-like and 1 blaDHA genes, highlighting the presence of plasmid-mediated AmpC in community-acquired isolates.
Fluoroquinolone-resistant and extended-spectrum β-lactamase-producing Escherichia coli from the milk of cows with clinical mastitis in Southern Taiwan.
The study identified several extended-spectrum beta-lactamase (ESBL) genes including bla TEM, bla CMY, bla CTX, bla SHV, and bla DHA in Escherichia coli isolates from cows with clinical mastitis. Additionally, mutations in gyrA and parC were associated with fluoroquinolone resistance.
Molecular characterization and epidemiology of cefoxitin resistance among Enterobacteriaceae lacking inducible chromosomal ampC genes from hospitalized and non-hospitalized patients in Algeria: description of new sequence type in Klebsiella pneumoniae isolates.
The study identified blaCMY-4 and blaDHA-1 as the primary plasmid-mediated AmpC beta-lactamase genes responsible for cefoxitin resistance in Enterobacteriaceae isolates in Algeria. Additionally, blaTEM-1, qnrB4, and aac(6')-Ib were found to coexist with these genes, contributing to multidrug resistance.
A locked nucleic acid (LNA)-based real-time PCR assay for the rapid detection of multiple bacterial antibiotic resistance genes directly from positive blood culture.
The study developed an LNA-qPCR assay for the rapid detection of 13 antibiotic resistance genes, including bla CTX-M-1, bla CTX-M-9, bla CMY-2, bla DHA-1, bla OXA-23, bla VIM-2, mecA, vanA, and vanB. The assay showed high specificity and sensitivity, with 91.5% concordance with phenotypic susceptibility testing.
Carbapenem-nonsusceptible Enterobacteriaceae in Taiwan.
The study identified several carbapenemase genes, including blaKPC-2, blaIMP-8, blaNDM-1, and blaVIM-1, along with extended-spectrum beta-lactamase genes such as CTX-M, SHV, and ampC beta-lactamase genes like DHA and CMY, which contribute to carbapenem resistance in Enterobacteriaceae isolates in Taiwan.
Clinical epidemiology and molecular analysis of extended-spectrum-β-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types 131 and 648.
The study identified bla CTX-M-15, aac (3)-IIa, aadA1, aadA2, aadA5, qnrB4, qnrS1, aac (6')-Ib-cr, bla OXA-1, bla TEM-1B, bla SHV-12, bla CMY-42, bla DHA-1, mphA, ermB, catA1, catB3, sul1, sul2, dfrA12, dfrA17, dfrA1, dfrA5, tetA, tetB, and tetD as key AMR genes in ESBL-producing E. coli isolates in Nepal, highlighting the prevalence of multidrug resistance.
Identification of DHA-23, a novel plasmid-mediated and inducible AmpC beta-lactamase from Enterobacteriaceae in Northern Taiwan.
The study identifies DHA-23, a novel plasmid-mediated and inducible AmpC beta-lactamase from Enterobacteriaceae in Northern Taiwan, which confers resistance to several beta-lactam antibiotics.
Identification of DHA-23, a novel plasmid-mediated and inducible AmpC beta-lactamase from Enterobacteriaceae in Northern Taiwan.
Identification of DHA-23, a novel plasmid-mediated and inducible AmpC beta-lactamase from Enterobacteriaceae in Northern Taiwan.
Identification of DHA-23, a novel plasmid-mediated and inducible AmpC beta-lactamase from Enterobacteriaceae in Northern Taiwan.
Identification of DHA-23, a novel plasmid-mediated and inducible AmpC beta-lactamase from Enterobacteriaceae in Northern Taiwan.
Molecular characteristics of extended-spectrum cephalosporin-resistant Enterobacteriaceae from humans in the community.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and others, as well as plasmidic AmpC genes like bla CMY-2 and bla DHA-1, in various Enterobacteriaceae isolates from healthy humans in the community.
In Vitro Activity of Imipenem and Colistin against a Carbapenem-Resistant Klebsiella pneumoniae Isolate Coproducing SHV-31, CMY-2, and DHA-1.
The study identified the presence of blaSHV-31, blaCMY-2, and blaDHA-1 genes in a carbapenem-resistant K. pneumoniae isolate, along with mutations in ompK35 and loss of ompK36, contributing to resistance against multiple antibiotics.
Point-of-care multiplex PCR promises short turnaround times for microbial testing in hospital-acquired pneumonia--an observational pilot study in critical ill patients.
The study evaluated the performance of a point-of-care multiplex PCR system for detecting pathogens and antibiotic resistance markers in hospital-acquired pneumonia. The system showed significantly shorter turnaround times compared to conventional microbiological diagnostics, although its performance was limited by frequent test failures and non-concordant results.
High Prevalence of AmpC beta-lactamases in Clinical Isolates of Escherichia coli in Ilam, Iran.
The study reports the high prevalence of AmpC beta-lactamases in clinical isolates of Escherichia coli in Iran, identifying the presence of FOX, CIT, DHA, and EBC cluster genes.
Comparative analysis of an IncR plasmid carrying armA, blaDHA-1 and qnrB4 from Klebsiella pneumoniae ST37 isolates.
The study identifies an MDR IncR plasmid carrying armA, blaDHA-1, and qnrB4 in K. pneumoniae ST37 isolates, highlighting the dissemination of these resistance genes.
Genotypic and Phenotypic Detection of AmpC beta-lactamases in Enterobacter spp. Isolated from a Teaching Hospital in Malaysia.
A novel plasmid-mediated AmpC gene, blaDHA, was identified in an Enterobacter cloacae isolate. This gene was found to confer resistance to cephalosporins.
Characterization of ESBL- and AmpC-Producing and Fluoroquinolone-Resistant Enterobacteriaceae Isolated from Mouflons (Ovis orientalis musimon) in Austria and Germany.
The study identified ESBL- and AmpC-producing Enterobacteriaceae in a mouflon, including E. coli ST744 carrying bla CTX-M-15 and bla OXA-1, and K. pneumoniae ST11 carrying bla SHV-11, bla OXA-1, bla DHA-1, and the PMQR gene qnrB55.
Detection and genotype analysis of AmpC beta-lactamase in Klebsiella pneumoniae from tertiary hospitals.
The study identified DHA-1 type AmpC beta-lactamase in Klebsiella pneumoniae isolates from tertiary hospitals, which conferred resistance to multiple antibiotics including cefoxitin, ceftriaxone, ceftazidime, cefepime, ciprofloxacin, aztreonam, piperacillin-tazobactam, amikacin, levofloxacin, and sulfamethoxazole.
Phenotypic and Molecular Characterization of Antimicrobial Resistance in Klebsiella spp. Isolates from Companion Animals in Japan: Clonal Dissemination of Multidrug-Resistant Extended-Spectrum beta-lactamase-Producing Klebsiella pneumoniae.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-15, blaCTX-M-14, blaCTX-M-55, and blaSHV-2, as well as the AmpC beta-lactamase gene blaDHA-1, in multidrug-resistant Klebsiella pneumoniae isolates from companion animals in Japan. Additionally, plasmid-mediated quinolone resistance (PMQR) genes such as qnrS, qnrB, aac(6')-Ib-cr, and oqxAB were detected, contributing to resistance against fluoroquinolones and aminoglycosides.
Why cannot a beta-lactamase gene be detected using an efficient molecular diagnostic method?
The study identifies a truncated bla DHA-1 gene in an E. coli isolate that was not detected by the large-scale bla Finder method, highlighting challenges in detecting truncated beta-lactamase genes.
High Prevalence of β-lactamase and Plasmid-Mediated Quinolone Resistance Genes in Extended-Spectrum Cephalosporin-Resistant Escherichia coli from Dogs in Shaanxi, China.
The study identified a high prevalence of β-lactamase and plasmid-mediated quinolone resistance genes in extended-spectrum cephalosporin-resistant Escherichia coli from dogs in Shaanxi, China. Key genes included bla CTX-M-15, bla TEM-1, bla SHV-12, and aac(6')-Ib-cr, along with other β-lactamase and PMQR genes.
Emergence of CMY-2- and DHA-1-type AmpC beta-lactamases in Enterobacter cloacae isolated from several hospitals of Qazvin and Tehran, Iran.
The study identified the emergence of bla DHA-1 and bla CMY-2 genes in clinical isolates of Enterobacter cloacae in Iran, indicating the presence of plasmid-mediated AmpC beta-lactamases conferring resistance to cefoxitin.
Emergence of serotype K1 Klebsiella pneumoniae ST23 strains co-producing the plasmid-mediated AmpC beta-lactamase DHA-1 and an extended-spectrum beta-lactamase in Korea.
The study identifies the plasmid-mediated AmpC beta-lactamase DHA-1 in three ESBL-producing serotype K1 K. pneumoniae ST23 strains, highlighting the emergence of multidrug-resistant strains in Korea.
Clinical and microbiologic characteristics of cefotaxime-non-susceptible Enterobacteriaceae bacteremia: a case control study.
The study identified several beta-lactamase genes, including CTX-M-14, CTX-M-27, CTX-M-15, CTX-M-55, CTX-M-2, SHV-12, SHV-27, DHA-1, and CMY-2, which confer resistance to cephalosporins in cefotaxime-non-susceptible Enterobacteriaceae isolates.
Panel strain of Klebsiella pneumoniae for beta-lactam antibiotic evaluation: their phenotypic and genotypic characterization.
The study characterizes various AMR genes and mutations in K. pneumoniae panel strains, including beta-lactamases (bla SHV-11, bla TEM-1, bla CTX-M15, bla OXA-1, bla SHV-12, bla SHV-187, bla SHV-158, bla DHA-1, bla CMY-2), aminoglycoside modifying enzymes (aac(6')-Ib, strA, strB, aadA1, aadA2), quinolone resistance genes (qnrB66, qnrB4, oqxA, oqxB), tetracycline resistance (tet(A)), trimethoprim resistance (dfrA14), sulfonamide resistance (sul1, sul2), and porin genes (OmpK35, OmpK36).
Detection of SGI1/PGI1 Elements and Resistance to Extended-Spectrum Cephalosporins in Proteae of Animal Origin in France.
The study identified several beta-lactamase genes, including blaVEB-6, blaCTX-M-1, blaCTX-M-15, blaCMY-2, and blaDHA-16, which confer resistance to extended-spectrum cephalosporins in Proteae isolates from animals in France.
Antibiotic-Resistant Extended Spectrum ß-Lactamase- and Plasmid-Mediated AmpC-Producing Enterobacteriaceae Isolated from Retail Food Products and the Pearl River in Guangzhou, China.
The study identified various beta-lactamase genes, including blaSHV-1, blaTEM-1, blaCTX-M-55, blaCTX-M-65, blaDHA-1, blaCMY-2, blaACC-1, and blaCIT, which confer resistance to multiple beta-lactam antibiotics in Enterobacteriaceae isolated from retail food and water samples in Guangzhou, China.
Development of a Rapid Reverse Blot Hybridization Assay for Detection of Clinically Relevant Antibiotic Resistance Genes in Blood Cultures Testing Positive for Gram-Negative Bacteria.
The study developed and evaluated the REBA-EAC assay for the rapid detection of clinically relevant antibiotic resistance genes in blood cultures positive for Gram-negative bacteria. The assay successfully identified various beta-lactamase genes, including ESBLs (CTX-M, TEM, SHV), AmpC beta-lactamases (DHA, CMY-2-like, ACT), and carbapenemases (IMP, VIM, NDM, KPC, OXA-48-like, SPM).
Occurrence of bla (DHA-1) mediated cephalosporin resistance in Escherichia coli and their transcriptional response against cephalosporin stress: a report from India.
The study identifies the occurrence of the bla(DHA-1) gene in Escherichia coli isolates, which mediates resistance to broad-spectrum cephalosporins. The gene shows increased transcription in response to various β-lactam antibiotics.
Multidrug Resistance Salmonella Genomic Island 1 in a Morganella morganii subsp. morganii Human Clinical Isolate from France.
The study reports the first identification of Salmonella genomic island 1 (SGI1) in a multidrug-resistant clinical isolate of Morganella morganii subsp. morganii, carrying resistance genes dfrA15, floR, tetA(G), blaCARB-2, and sul1, conferring resistance to trimethoprim, chloramphenicol, tetracycline, ticarcillin, and sulfonamides, respectively.
Distribution of Integrons and Phylogenetic Groups among Enteropathogenic Escherichia coli Isolates from Children <5 Years of Age in Delhi, India.
The study identified various AMR genes including dfrA1, dfrA7, dfrA12, aadA1, aadA2, sul1, tetA, aacC1, TEM, SHV, CTX-M, OXA, NDM-1, IMP, VIM, ACT, DHA, and CMY in E. coli isolates from children in Delhi, India. These genes were associated with resistance to multiple antibiotics such as trimethoprim, streptomycin, sulfonamides, tetracycline, gentamicin, and various beta-lactams.
Klebsiella pneumoniae Isolates from Meningitis: Epidemiology, Virulence and Antibiotic Resistance.
The study identified several beta-lactamase genes (blaSHV-5, blaTEM-1B, blaCMY-2, and blaDHA-1) associated with resistance to cefotaxime and ceftazidime in Klebsiella pneumoniae isolates from meningitis. These genes were predominantly found in post-craniotomy meningitis isolates.
Evolving beta-lactamase epidemiology in Enterobacteriaceae from Italian nationwide surveillance, October 2013: KPC-carbapenemase spreading among outpatients.
The study identified the prevalence of beta-lactamase genes, including bla CTX-M-1, bla CTX-M-9, bla KPC, bla VIM, bla OXA-48, and bla NDM, in Enterobacteriaceae isolates from Italy. It highlighted the increasing spread of CTX-M-type enzymes and KPC-carbapenemase among outpatients.
Co-Occurrence of Plasmid-Mediated AmpC beta-lactamase Activity Among Klebsiella pneumoniae and Escherichia Coli.
The study identified plasmid-mediated AmpC beta-lactamase genes, including bla CMY, bla MOX, bla DHA, and bla EBC, in Klebsiella pneumoniae and Escherichia coli isolates from Libya. These genes conferred resistance to cefoxitin and cefepime.
Antimicrobial susceptibility and molecular epidemiology of clinical Enterobacter cloacae bloodstream isolates in Shanghai, China.
The study identified several AMR genes in Enterobacter cloacae bloodstream isolates, including ESBLs (SHV-12, CTX-M-15, CTX-M-65), carbapenemases (IMP-26, NDM-1), plasmid-mediated AmpC beta-lactamases (ACT-20, ACT-3, DHA-1), and TEM-1. These genes were associated with resistance to various antibiotics, highlighting the need for continued surveillance.
Faecal colonization of E. coli and Klebsiella spp. producing extended-spectrum beta-lactamases and plasmid-mediated AmpC in Mozambican university students.
The study identified various extended-spectrum beta-lactamase (ESBL) and plasmid-mediated AmpC (pAmpC) genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-186, bla DHA, bla MOX, bla FOX, and bla CMY, in E. coli and Klebsiella spp. isolates from Mozambican university students.
Piperacillin-Tazobactam Versus Meropenem for Bloodstream Infections Caused by Ceftriaxone-Nonsusceptible Escherichia coli and Klebsiella spp.
The study identified bla DHA-1 and bla OXA-162 as mechanisms of resistance to piperacillin-tazobactam and meropenem respectively in E. coli and K. pneumoniae bloodstream infections.
Novel Multidrug-Resistant Cronobacter sakazakii Causing Meningitis in Neonate, China, 2015
The study identifies the blaDHA-1 gene, encoding an AmpC beta-lactamase, as a contributor to cephalosporin resistance in a multidrug-resistant Cronobacter sakazakii strain causing meningitis in a neonate.
Characterization of Gene Families Encoding Beta-Lactamases of Gram-Negative Rods Isolated from Ready-to-Eat Vegetables in Mexico City.
The study identified various beta-lactamase genes, including blaBIL, blaSHV, blaCTX, blaDHA, blaVIM, blaOXA, blaIMP, blaKPC, and blaTEM, which confer resistance to beta-lactam antibiotics in Enterobacteriaceae isolated from ready-to-eat vegetables in Mexico City.
Travel to Asia is a strong predictor for carriage of cephalosporin resistant E. coli and Klebsiella spp. but does not explain everything; prevalence study at a Norwegian hospital 2014-2016.
The study identified bla CTX-M-15, bla CTX-M-55, bla CTX-M-27, bla OXA-1, bla CTX-M-14, bla CTX-M-1, bla CTX-M-3, bla TEM-33, bla DHA-1, and bla CMY-42 as the main genes responsible for extended-spectrum cephalosporin resistance in E. coli and Klebsiella spp. Travel to Asia was a strong predictor for carriage of these resistant strains.
Endogenous endophthalmitis caused by a multidrug-resistant hypervirulent Klebsiella pneumoniae strain belonging to a novel single locus variant of ST23: first case report in China.
The study identifies a multidrug-resistant hypervirulent Klebsiella pneumoniae strain, KP587, which exhibits resistance to multiple antibiotics including ceftazidime, ceftriaxone, piperacillin-tazobactam, amikacin, and gentamicin. The strain harbors the ESBL gene blaCTX-M-14, the AmpC beta-lactamase gene blaDHA, the 16S rRNA methylase gene armA, and the quinolone resistance gene qnrB.
Acquisition of plasmid-mediated cephalosporinase producing Enterobacteriaceae after a travel to the tropics.
The study identified CMY-2, CMY-42, CMY-6, and DHA plasmid-mediated cephalosporinase genes in Enterobacteriaceae acquired by travelers to tropical regions, with CMY-2 being the most prevalent. New variants CMY-2m and CMY-42m were also discovered.
Characterization of Antimicrobial Resistance in Serratia spp. and Citrobacter spp. Isolates from Companion Animals in Japan: Nosocomial Dissemination of Extended-Spectrum Cephalosporin-Resistant Citrobacter freundii.
The study identified bla CTX-M-3, bla CMY-1, and bla DHA-1 as the primary mechanisms of extended-spectrum cephalosporin resistance in Citrobacter spp. isolates from companion animals in Japan.
Transcriptome analysis of beta-lactamase genes in diarrheagenic Escherichia coli.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
Metal impacts on the persistence and proliferation of β-lactam resistance genes in Xiangjiang River, China.
The study identifies and characterizes the persistence and proliferation of various β-lactam resistance genes (blaTEM, blaVIM, blaSHV, blaGES, blaDHA, blaOXA-1, blaOXA-2, blaOXA-10, blaCMY-2, and blaampC) in the Xiangjiang River, highlighting the impact of heavy metals on their distribution and the role of bacterial communities in their persistence.
Carriage of carbapenemase- and extended-spectrum cephalosporinase-producing Escherichia coli and Klebsiella pneumoniae in humans and livestock in rural Cambodia; gender and age differences and detection of bla(OXA-48) in humans.
The study identified various beta-lactamase genes such as bla CTX-M27, bla CTX-M55, bla CTX-M15, bla CTX-M14, bla CMY-2, bla CMY-42, bla SHV-2, bla SHV-12, bla SHV-28, bla SHV-1, bla DHA-1, and bla OXA-48, along with colistin resistance genes mcr-1-like and mcr-3-like in Escherichia coli and Klebsiella pneumoniae isolates from humans and livestock in Cambodia.
Induction of plasmid-mediated AmpC beta-lactamase DHA-1 by piperacillin/tazobactam and other β-lactams in Enterobacteriaceae.
The study characterizes the plasmid-mediated AmpC beta-lactamase DHA-1 and shows that its induction by various β-lactams, including piperacillin/tazobactam, is limited in Enterobacteriaceae.
First Clinical Case of In Vivo Acquisition of DHA-1 Plasmid-Mediated AmpC in a Salmonella enterica subsp. enterica Isolate.
The study reports the first clinical case of in vivo acquisition of a DHA-1 plasmid-mediated AmpC beta-lactamase in a Salmonella enterica subsp. enterica isolate, highlighting the potential for horizontal gene transfer of resistance determinants in clinical settings.
Development of an algorithm to discriminate between plasmid- and chromosomal-mediated AmpC beta-lactamase production in Escherichia coli by elaborate phenotypic and genotypic characterization.
The study identifies bla CMY-2 and bla DHA-1 as the primary plasmid-mediated AmpC beta-lactamase genes responsible for resistance to third-generation cephalosporins in E. coli. An algorithm based on cefotaxime MIC values was developed to distinguish between plasmid-mediated and chromosomal-mediated AmpC production.
An Outbreak of Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae in an Intensive Care Unit of a Major Teaching Hospital in Wenzhou, China.
The study identified carbapenem-resistant and hypervirulent Klebsiella pneumoniae isolates carrying bla KPC−2, aac(3')-Ia, aac(6')-Ib, ANT(3')-Ia, rmtB, rmtC, qnrB, qnrS, oqxA, bla SHV−11, bla CTX−M−2 group, bla CTX−M−9 group, bla TEM−1, bla CMY−2, and bla DHA genes, contributing to multidrug resistance.
Multiple β-Lactam Resistance Gene-Carrying Plasmid Harbored by Klebsiella quasipneumoniae Isolated from Urban Sewage in Japan.
The study identifies a plasmid carrying four beta-lactamase genes, including the rare carbapenemase KHM-1, in a carbapenem-resistant Klebsiella quasipneumoniae isolate from urban sewage in Japan. The plasmid pTMSNI47-1 was found to confer broad-spectrum β-lactam resistance through the cooperative effects of its beta-lactamase genes.
Genetic characterization of a novel sequence type of multidrug-resistant Citrobacter freundii strain recovered from wastewater treatment plant.
The study reports the identification of a multidrug-resistant Citrobacter freundii strain R17 carrying 13 antibiotic-resistance genes, including blaCMY-85, aadA2, aac(3)-lld, blaDHA-1, blaTEM-1B, qnrB4, mph(A), catA2, sul1, sul2, tet(D), and dfrA12, which confer resistance to various antibiotic classes.
Carbapenem-Resistant Enterobacter hormaechei ST1103 with IMP-26 Carbapenemase and ESBL Gene bla (SHV-178).
The study identifies a multidrug-resistant Enterobacter hormaechei strain L51 carrying the bla IMP-26 carbapenemase gene and bla SHV-178 ESBL gene, along with other resistance genes on a conjugative IncHI2/2A plasmid.
Molecular and Clinical Characterization of Multidrug-Resistant and Hypervirulent Klebsiella pneumoniae Strains from Liver Abscess in Taiwan.
Ceftazidime-Avibactam Resistance Mediated by the N346Y Substitution in Various AmpC β-Lactamases.
The N346Y substitution in AmpC cloacae, PDC-5, and DHA-1 reduces avibactam inhibition, leading to ceftazidime resistance. The I346Y substitution in FOX-3 reduces ceftazidime hydrolysis, leading to ceftazidime resistance.
Deadly Puppy Infection Caused by an MDR Escherichia coli O39 bla (CTX-M-15), bla (CMY-2), bla (DHA-1), and aac(6)-Ib-cr - Positive in a Breeding Kennel in Central Italy.
The study characterizes an MDR E. coli O39 strain carrying multiple AMR genes including bla CTX-M-15, bla CMY-2, bla DHA-1, and aac(6')-Ib-cr, highlighting the complexity of the resistome in this outbreak.
Antimicrobial Resistance in Swine Fecal Specimens Across Different Farm Management Systems.
The study identified several AMR genes associated with different antimicrobial classes in swine fecal samples from farms with varying antimicrobial usage levels. These genes included beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, macrolide resistance markers, polymyxin resistance genes, phenicol resistance genes, and trimethoprim resistance genes.
Tracking Recombination Events That Occur in Conjugative Virulence Plasmid p15WZ-82_Vir during the Transmission Process.
The study characterizes the recombination events in the conjugative virulence plasmid p15WZ-82_Vir during transmission, identifying multiple antibiotic resistance genes and their roles in the formation of mosaic plasmids that carry both virulence and resistance traits.
Escherichia coli ST8196 is a novel, locally evolved, and extensively drug resistant pathogenic lineage within the ST131 clonal complex.
The study identified a novel sequence type, ST8196, within the ST131 clonal complex, which exhibits extensive drug resistance. Key resistance mechanisms include the presence of blaCTX-M-15, qnrB4, and blaDHA-1 genes, along with chromosomal mutations in parC and gyrA contributing to fluoroquinolone resistance.
Conjugative plasmidic AmpC detected in Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae human clinical isolates from Portugal.
The study detected plasmidic AmpC genes (blaCIT, blaCMY, and blaDHA) in clinical isolates of Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae from Portugal, confirming their role in β-lactam resistance through PCR and phenotypic analysis.
Replication of the Salmonella Genomic Island 1 (SGI1) triggered by helper IncC conjugative plasmids promotes incompatibility and plasmid loss.
The study identifies the rep gene as essential for the replication of Salmonella Genomic Island 1 (SGI1) in the presence of IncC plasmids. The rep gene, encoding a putative replication initiator protein, is necessary for SGI1 replication, and its deletion leads to a significant reduction in SGI1 copy number.
Characterization and Source Investigation of Multidrug-Resistant Salmonella Anatum from a Sustained Outbreak, Taiwan.
The study identifies blaDHA-1, qnrB, and blaCMY-2 as key AMR genes in multidrug-resistant Salmonella Anatum isolates from a sustained outbreak in Taiwan.
Emergence of Hypervirulent Ceftazidime/Avibactam-Resistant Klebsiella pneumoniae Isolates in a Chinese Tertiary Hospital.
The study identifies the emergence of ceftazidime/avibactam-resistant hypervirulent Klebsiella pneumoniae isolates, primarily associated with the presence of metallo-beta-lactamases (NDM-1, NDM-5), KPC-2, and DHA-1 beta-lactamases, as well as the loss of porin genes ompK35 and ompK36.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2017/2018.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, focusing on Salmonella, Campylobacter, and E. coli. It notes high resistance levels to ampicillin, sulfonamides, and tetracyclines in Salmonella and E. coli isolates, along with rising resistance to fluoroquinolones in certain serovars. Carbapenemase-producing E. coli and Salmonella were rarely detected.
Outbreak of multi-drug-resistant (MDR) Shigella flexneri in northern Australia due to an endemic regional clone acquiring an IncFII plasmid.
The study identifies several AMR genes in a multi-drug-resistant Shigella flexneri strain, including bla DHA, bla OXA-1, tet(B), catA1, dfrA1, mph(A), ermB, qnrB, aadA, and qacEΔ1, which confer resistance to various antibiotics such as beta-lactams, tetracyclines, chloramphenicol, trimethoprim, macrolides, quinolones, aminoglycosides, and quaternary ammonium compounds.
Molecular Epidemiology of Escherichia coli Producing CTX-M and pAmpC beta-lactamases from Dairy Farms Identifies a Dominant Plasmid Encoding CTX-M-32 but No Evidence for Transmission to Humans in the Same Geographical Region.
The study identified bla CTX-M-32 as the most common 3GC-R gene in E. coli isolates from dairy farms, with no evidence of transmission to humans in the same geographical region. Other 3GC-R genes detected include bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-214, bla DHA-1, and bla CMY-2.
Characteristics and Epidemiology of Extended-Spectrum β-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae From Red Kangaroo, China.
The study identified multiple AMR genes in a multidrug-resistant Klebsiella pneumoniae isolate from a Red Kangaroo, including beta-lactamases (bla DHA–3, bla SHV–1, bla CTX–M–14, bla TEM–191, bla TEM–1, bla CTX–M–3), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aac(3)-IIa, aac(6′)-Ib-cr, aadA16, arr-3), quinolone resistance genes (qnrS1, qnrB2), macrolide resistance gene (mphA), sulfonamide resistance genes (sul3, sul1), dihydrofolate reductase (dfrA3, dfrA27), chloramphenicol resistance gene (floR), tetracycline resistance genes (tetG, tetR), and multidrug efflux pump (qacEΔ1).
A Multifactorial Approach for Surveillance of Shigella spp. and Entero-Invasive Escherichia coli Is Important for Detecting (Inter)national Clusters.
The study identified several AMR genes and mutations in Shigella spp. and EIEC isolates, including beta-lactamases (blaTEM-1b, blaOXA-1, blaCTX-M-15, blaCTX-M-32, blaCTX-M-55, blaDHA-1), dihydrofolate reductase variants (dfrA1, dfrA14, dfrA17, dfrA7, dfrA8), sulfonamide resistance genes (sul1, sul2), macrolide resistance genes (erm(B), mphA), and chromosomal mutations in gyrA, parC, and parE associated with ciprofloxacin resistance.
The importance of using whole genome sequencing and extended spectrum beta-lactamase selective media when monitoring antimicrobial resistance.
The study highlights the utility of whole genome sequencing (WGS) in monitoring antimicrobial resistance (AMR) trends, particularly in identifying ESBL genes such as bla CTX-M-1, bla CTX-M-15, bla SHV-12, bla CMY-2, and bla DHA-1, along with other resistance genes like sul2, tet(A), dfrA17, aadA5, ant3-1a, strA, strB, and fosA3 in E. coli isolates from pig surveillance.
Prevalence, phylogeny, and antimicrobial resistance of Escherichia coli pathotypes isolated from children less than 5 years old with community acquired- diarrhea in Upper Egypt.
The study identified blaTEM, blaCTX-M-15, and DHA genes in Escherichia coli isolates from children with diarrhea, indicating the presence of extended-spectrum beta-lactamases and AmpC beta-lactamases, contributing to multidrug resistance.
The Novel CarbaLux Test for Carbapenemases and Carbapenem Deactivating AmpC Beta-Lactamases.
The CarbaLux test was developed to rapidly detect carbapenemase-producing bacteria, including various OXA-type carbapenemases (OXA-23, OXA-24/40, OXA-48, OXA-181) and other carbapenemases (KPC, NDM, VIM, IMP-1, OXA-58). It also detects hyper-produced AmpC beta-lactamases, which deactivate carbapenems but are not detectable by previous rapid phenotypic assays.
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing.
The study identified various AMR genes in E. coli isolates from bloodstream infections, including genes conferring resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, and trimethoprim. Additionally, mutations in quinolone resistance-determining regions of gyrA, parC, and parE were associated with ciprofloxacin resistance.
Colonization with Staphylococcus aureus and Klebsiella pneumoniae causes infections in a Vietnamese intensive care unit.
The study identifies multidrug-resistant Staphylococcus aureus ST188 and various Klebsiella pneumoniae strains with distinct resistance mechanisms, highlighting the role of colonization in causing infections in ICU patients.
Molecular Epidemiology and Characterization of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Urine at a Teaching Hospital in Taiwan.
The study identified several AMR genes and mutations contributing to carbapenem resistance in K. pneumoniae isolates from urine, including bla TEM, bla SHV, bla CTX-M, bla DHA, bla KPC, bla VIM, and mutations in ompK35 and ompK36.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Prevalence and antimicrobial resistance of Klebsiella species isolated from clinically ill companion animals.
The study identified several extended-spectrum cephalosporin (ESC) resistance genes, including blaCTX-M-15, blaCTX-M-3, blaCTX-M-65, blaDHA-1, blaCMY-2, blaSHV-1, blaSHV-11, blaSHV-28, and blaTEM-1, in Klebsiella pneumoniae and Klebsiella oxytoca strains isolated from clinically ill companion animals. These genes were associated with resistance to various beta-lactam antibiotics.
ESBL and AmpC beta-lactamase Encoding Genes in E. coli From Pig and Pig Farm Workers in Vietnam and Their Association With Mobile Genetic Elements.
The study identified several ESBL and AmpC beta-lactamase encoding genes, including bla CTX-M-55, bla CTX-M-27, bla CTX-M-65, bla CTX-M-15, bla CTX-M-14, bla CMY-2, bla DHA-1, and bla CMY-42, in E. coli isolates from pigs and pig farm workers in Vietnam. These genes were found to be primarily plasmid-mediated and associated with various mobile genetic elements.
Deceiving Phenotypic Susceptibility Results on a Klebsiella pneumoniae Blood Isolate Carrying Plasmid-Mediated AmpC Gene bla(DHA-1).
The study identifies a carbapenem-resistant Klebsiella pneumoniae isolate carrying the plasmid-mediated AmpC gene blaDHA-1, along with other resistance genes such as blaOXA-1, aac(6')-Ib-cr, aph(3')-Ia, sul1, oqxA, oqxB, qnrB4, arr-3, tet(A), catB3, mph(A), fosA, IncFIB(K), and IncR.
Characterization of Extended-Spectrum β-Lactamase-Producing and AmpC β-Lactamase-Producing Enterobacterales Isolated from Companion Animals in Korea.
The study identified several extended-spectrum β-lactamase (ESBL) and AmpC β-lactamase genes, including bla TEM, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla CTX-M-61, bla CTX-M-27, bla CTX-M-65, bla CIT, bla DHA, bla EBC, and bla SHV, in various Enterobacterales isolates from companion animals in South Korea.
Combining Functional Genomics and Whole-Genome Sequencing to Detect Antibiotic Resistance Genes in Bacterial Strains Co-Occurring Simultaneously in a Brazilian Hospital.
Combining Functional Genomics and Whole-Genome Sequencing to Detect Antibiotic Resistance Genes in Bacterial Strains Co-Occurring Simultaneously in a Brazilian Hospital.
Combining Functional Genomics and Whole-Genome Sequencing to Detect Antibiotic Resistance Genes in Bacterial Strains Co-Occurring Simultaneously in a Brazilian Hospital.
Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance.
The study identifies plasmid-mediated cephalosporin resistance in Salmonella Typhi isolates from India, including bla SHV-12, bla TEM-1B, bla DHA-1, qnrB7, qnrB4, aac(6')Iaa, dfrA14, sul1, and sul2 genes. Chromosomal mutations in gyrA (S83F, D87N, S80I) and parC (S80I, E84K) contribute to fluoroquinolone resistance.
A Rapid Antimicrobial Susceptibility Test for Klebsiella pneumoniae Using a Broth Micro-Dilution Combined with MALDI TOF MS.
The study identifies and characterizes resistance genes blaKPC, blaCTX-M, blaFOX, and blaDHA in carbapenem-resistant Klebsiella pneumoniae strains, demonstrating their role in conferring resistance to ceftriaxone and imipenem.
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
In Vitro Activity of Cefotetan against ESBL-Producing Escherichia coli and Klebsiella pneumoniae Bloodstream Isolates from the MERINO Trial.
Cefotetan demonstrated favorable in vitro efficacy against ESBL-producing E. coli and K. pneumoniae bloodstream isolates, with MIC 50 and MIC 90 values of 0.25 mg/L and 2 mg/L, respectively. Isolates carrying ampC genes showed higher MICs, while those with CTX-M-15 had lower MICs. Several beta-lactamase genes, including bla CTX-M-15, bla CTX-M-27, bla SHV-106, and bla DHA-1, were identified as contributors to resistance.
Meropenem Versus Piperacillin-Tazobactam for Definitive Treatment of Bloodstream Infections Caused by AmpC β-Lactamase-Producing Enterobacter spp, Citrobacter freundii, Morganella morganii, Providencia spp, or Serratia marcescens: A Pilot Multicenter Randomized Controlled Trial (MERINO-2).
The study identified several AmpC β-lactamase genes, including bla CMY-2, bla CMY-101, bla CMY-51, bla ACT-17, bla ACT-12, bla ACT-15, bla ACT-16, bla ACT-2, bla ACT-27, bla ACT-38, bla ACT-40, bla ACT-43, bla ACT-49, bla ACT-55, bla CMH-3, bla CMH-1, bla DHA-17, bla DHA-20, bla DHA-12, bla DHA-16, bla DHA-18, bla MIR-18, bla MIR-19, and bla MIR-9, which confer resistance to piperacillin-tazobactam in various Enterobacterales species.
Meropenem Versus Piperacillin-Tazobactam for Definitive Treatment of Bloodstream Infections Caused by AmpC β-Lactamase-Producing Enterobacter spp, Citrobacter freundii, Morganella morganii, Providencia spp, or Serratia marcescens: A Pilot Multicenter Randomized Controlled Trial (MERINO-2).
The study identified several AmpC β-lactamase genes, including bla CMY-2, bla CMY-101, bla CMY-51, bla ACT-17, bla ACT-12, bla ACT-15, bla ACT-16, bla ACT-2, bla ACT-27, bla ACT-38, bla ACT-40, bla ACT-43, bla ACT-49, bla ACT-55, bla CMH-3, bla CMH-1, bla DHA-17, bla DHA-20, bla DHA-12, bla DHA-16, bla DHA-18, bla MIR-18, bla MIR-19, and bla MIR-9, which confer resistance to piperacillin-tazobactam in various Enterobacterales species.
Meropenem Versus Piperacillin-Tazobactam for Definitive Treatment of Bloodstream Infections Caused by AmpC β-Lactamase-Producing Enterobacter spp, Citrobacter freundii, Morganella morganii, Providencia spp, or Serratia marcescens: A Pilot Multicenter Randomized Controlled Trial (MERINO-2).
The study identified several AmpC β-lactamase genes, including bla CMY-2, bla CMY-101, bla CMY-51, bla ACT-17, bla ACT-12, bla ACT-15, bla ACT-16, bla ACT-2, bla ACT-27, bla ACT-38, bla ACT-40, bla ACT-43, bla ACT-49, bla ACT-55, bla CMH-3, bla CMH-1, bla DHA-17, bla DHA-20, bla DHA-12, bla DHA-16, bla DHA-18, bla MIR-18, bla MIR-19, and bla MIR-9, which confer resistance to piperacillin-tazobactam in various Enterobacterales species.
Meropenem Versus Piperacillin-Tazobactam for Definitive Treatment of Bloodstream Infections Caused by AmpC β-Lactamase-Producing Enterobacter spp, Citrobacter freundii, Morganella morganii, Providencia spp, or Serratia marcescens: A Pilot Multicenter Randomized Controlled Trial (MERINO-2).
The study identified several AmpC β-lactamase genes, including bla CMY-2, bla CMY-101, bla CMY-51, bla ACT-17, bla ACT-12, bla ACT-15, bla ACT-16, bla ACT-2, bla ACT-27, bla ACT-38, bla ACT-40, bla ACT-43, bla ACT-49, bla ACT-55, bla CMH-3, bla CMH-1, bla DHA-17, bla DHA-20, bla DHA-12, bla DHA-16, bla DHA-18, bla MIR-18, bla MIR-19, and bla MIR-9, which confer resistance to piperacillin-tazobactam in various Enterobacterales species.
Meropenem Versus Piperacillin-Tazobactam for Definitive Treatment of Bloodstream Infections Caused by AmpC β-Lactamase-Producing Enterobacter spp, Citrobacter freundii, Morganella morganii, Providencia spp, or Serratia marcescens: A Pilot Multicenter Randomized Controlled Trial (MERINO-2).
The study identified several AmpC β-lactamase genes, including bla CMY-2, bla CMY-101, bla CMY-51, bla ACT-17, bla ACT-12, bla ACT-15, bla ACT-16, bla ACT-2, bla ACT-27, bla ACT-38, bla ACT-40, bla ACT-43, bla ACT-49, bla ACT-55, bla CMH-3, bla CMH-1, bla DHA-17, bla DHA-20, bla DHA-12, bla DHA-16, bla DHA-18, bla MIR-18, bla MIR-19, and bla MIR-9, which confer resistance to piperacillin-tazobactam in various Enterobacterales species.
Evaluation of Two Phenotypic Methods for the Detection of Plasmid-Mediated AmpC beta-lactamases among Enterobacteriaceae Isolates.
The study evaluated two phenotypic methods for detecting plasmid-mediated AmpC beta-lactamases in Enterobacteriaceae isolates and identified several plasmid-mediated AmpC genes including ACC, FOX, MOX, DHA, CIT, and EBC using multiplex PCR.
Molecular detection of plasmid-derived AmpC β-lactamase among clinical strains of Enterobacteriaceae in Bahrain.
The study identifies plasmid-mediated AmpC β-lactamase genes (ACC, FOX, MOX, DHA, CIT, EBC) in clinical isolates of Enterobacteriaceae in Bahrain, highlighting their association with multidrug resistance.
ESBL/pAmpC-producing Escherichia coli and Klebsiella pneumoniae carriage among veterinary healthcare workers in the Netherlands.
The study identified bla CTX-M-15, bla CTX-M-14, and bla DHA-1 as the most prevalent ESBL/pAmpC resistance genes among veterinary healthcare workers in the Netherlands, with bla CTX-M-15 being the most common.
Use of Molecular Methods To Detect Shigella and Infer Phenotypic Resistance in a Shigella Treatment Study.
The study identified several AMR genes including ermB, mphA, blaTEM, blaCTX-M1, blaDHA, blaOXA-1, dfrA, and sul in Shigella isolates. Mutations in gyrA (83L) and parC (80I) were associated with ciprofloxacin resistance.
Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms.
The study identified several ESBL genes, colistin resistance genes, and other AMR genes in ESBL-producing E. coli from pigs and pig farm workers in Vietnam. Key findings include the prevalence of bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27, along with mcr-1 and mcr-3 for colistin resistance, and various other resistance genes for aminoglycosides, quinolones, tetracyclines, chloramphenicol, macrolides, and sulfonamides.
Whole-Genomic Analysis of NDM-5-Producing Enterobacteriaceae Recovered from an Urban River in China.
The study identified multiple antimicrobial resistance genes, including bla NDM-5, bla OXA-10, and bla TEM-1B, in NDM-5-producing Enterobacteriaceae isolates from an urban river in China. These genes conferred resistance to various antibiotics such as carbapenems, cephalosporins, quinolones, and aminoglycosides.
Co-conjugation of Virulence Plasmid and KPC Plasmid in a Clinical Klebsiella pneumoniae Strain.
The study characterizes a carbapenem-resistant hypervirulent Klebsiella pneumoniae strain that harbors a conjugative virulence plasmid and a bla KPC–2-bearing plasmid. The virulence plasmid contains multiple resistance genes, including bla KPC–2, qnrB4, bla DHA–1, sul1, msr(E), mph(E), bla TEM–1B, aac(3)-IId, bla SHV–12, mph(A), bla CTX–M–65, bla TEM–1B, fosA3, and rmtB. The study also shows that these plasmids can be transferred to other bacterial strains, contributing to the spread of multidrug-resistant and hypervirulent K. pneumoniae.
Prevalence of plasmid-mediated AmpC beta-lactamases among uropathogenic Escherichia coli isolates in southwestern Iran.
The study identified the presence of plasmid-mediated AmpC beta-lactamase genes (blaDHA, blaCIT, and blaEBC) in E. coli isolates from southwestern Iran, with blaDHA being the most prevalent.
Impact of Carbapenem Heteroresistance Among Multidrug-Resistant ESBL/AmpC-Producing Klebsiella pneumoniae Clinical Isolates on Antibiotic Treatment in Experimentally Infected Mice.
Three IPM-heteroresistant strains of MDR ESBL/AmpC-producing K. pneumoniae were identified, which exhibited reduced expression of ompK36 and failed IPM therapy in a mouse model of peritonitis.
Surveillance of antimicrobial-resistant Escherichia coli in Sheltered dogs in the Kanto Region of Japan.
The study identified beta-lactamase genes (blaTEM, blaDHA-1, blaCTX-M-9 group CTX-M-14), quinolone-resistance protein genes (qnrB, qnrS), and mutations in quinolone-resistance-determining regions (gyrA and parC) in multidrug-resistant E. coli isolates from shelter dogs in the Kanto Region of Japan.
Flomoxef and fosfomycin in combination for the treatment of neonatal sepsis in the setting of highly prevalent antimicrobial resistance.
The study evaluated the combination of flomoxef and fosfomycin for treating neonatal sepsis in settings with high antimicrobial resistance. It found that the combination showed synergy in bacterial killing and prevented the emergence of fosfomycin resistance. Specific AMR genes and mutations were identified in Enterobacterales strains, including beta-lactamases and efflux pumps.
Antimicrobial Resistance (AMR) of Bacteria Isolated from Dogs with Canine Parvovirus (CPV) Infection: The Need for a Rational Use of Antibiotics in Companion Animal Health.
The study identified several beta-lactamase genes, including blaTEM, blaCTX-M-II, blaSHV, blaOXA, and blaDHA, which confer resistance to various antibiotics in bacteria isolated from dogs with canine parvovirus infection.
Comparative phylogenomics of ESBL-, AmpC- and carbapenemase-producing Klebsiella pneumoniae originating from companion animals and humans.
The study identifies bla CTX-M-15, bla DHA-1, and bla OXA-48 as the primary resistance genes in ESBL-, AmpC-, and carbapenemase-producing Klebsiella pneumoniae isolates from companion animals and humans. Additionally, mutations in mgrB and the presence of mcr-9 were linked to colistin resistance.
Genomics of human and chicken Salmonella isolates in Senegal: Broilers as a source of antimicrobial resistance and potentially invasive nontyphoidal salmonellosis infections.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella isolates from Senegal, highlighting the prevalence of resistance to fluoroquinolones, sulfamethoxazole-trimethoprim, tetracycline, and erythromycin. Key genes included aac(3)-Id, aadA7, blaTEM-1b, blaDHA-1, blaOXA-10, blaCMY-2, dfrA1, dfrA14, floR, fosA, qnrB19, qnrB7, sul2, tetA, tetB, aph(3')-Ib, aph(3")-Ib, and aph(6)-Id. Mutations in parC and gyrA were also associated with fluoroquinolone resistance.
Multidrug-Resistant Klebsiella pneumoniae Complex From Clinical Dogs and Cats in China: Molecular Characteristics, Phylogroups, and Hypervirulence-Associated Determinants.
The study identified multidrug-resistant Klebsiella pneumoniae complex isolates from clinical dogs and cats in China, highlighting the presence of various AMR genes such as bla SHV, bla CTX-M, bla NDM-5, aac(6')Ib-cr, qnrB, qnrS, oqxAB, aph(3')-Ia, aph(3')-Ib, bla OXA, bla DHA, bla LEN, and bla OKP.
β-Lactam Antibiotics and beta-lactamase Enzymes Inhibitors, Part 2: Our Limited Resources.
The paper reviews β-lactam antibiotics and beta-lactamase enzymes inhibitors, focusing on the mechanisms of resistance mediated by beta-lactamases such as TEM-1, SHV-1, KPC-2, OXA-48, and NDM-1, and highlights the need for new inhibitors to combat carbapenem-resistant bacteria.
Multidrug Resistance Genes Carried by a Novel Transposon Tn7376 and a Genomic Island Named MMGI-4 in a Pathogenic Morganella morganii Isolate.
The study identifies a novel transposon Tn7376 and a genomic island MMGI-4 in a multidrug-resistant Morganella morganii isolate, carrying multiple antimicrobial resistance genes including dfrA24, mph(A), aadA1, sul1, floR, catA2, cmlA1, aph(3')-Ia, aac(6')-Ib-cr, tet(A), tet(B), arr-3, blaTEM-1B, blaDHA-17, blaCARB-2, blaOXA-1, blaCTX-M-3, and fosA3.
In Vitro Activity and Clinical Efficacy of Faropenem against Third-Generation Cephalosporin-Resistant Escherichia coli and Klebsiella pneumoniae.
The study identified several beta-lactamase genes, including blaCTX-M-1, blaCTX-M-9, blaTEM, blaSHV, blaCIT, and blaDHA, which confer resistance to third-generation cephalosporins in Escherichia coli and Klebsiella pneumoniae. These genes were experimentally characterized through PCR and genotyping.
Genomic surveillance of Salmonella spp. in the Philippines during 2013-2014.
The study characterized various AMR genes and mutations in Salmonella isolates from the Philippines, highlighting the presence of ESBL genes, plasmid-mediated quinolone resistance genes, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Prevalence and Molecular Characterization of Extended-Spectrum β-Lactamases and AmpC β-lactamase-Producing Enterobacteriaceae among Human, Cattle, and Poultry.
The study identified blaSHV, blaTEM, blaCTX-M, blaFOX, blaDHA, and blaACC genes as the primary contributors to extended-spectrum beta-lactamase and AmpC beta-lactamase production in Enterobacteriaceae isolated from humans, cattle, and poultry in Egypt.
Evaluation of the EasyScreen™ ESBL/CPO Detection Kit for the Detection of ß-Lactam Resistance Genes.
The EasyScreen™ ESBL/CPO Detection Kit effectively detects various β-lactam resistance genes, including bla VIM, bla NDM, bla IMP, bla OXA-48, bla KPC, bla OXA-23, bla OXA-51, bla SME, bla IMI, bla GES, bla TEM, bla SHV, bla CTX-M, bla CMY, bla DHA, and the mcr-1 gene, demonstrating high sensitivity and specificity for carbapenemase and ESBL detection in Enterobacterales, Pseudomonas spp., and Acinetobacter spp.
Resistance and virulence features of hypermucoviscous Klebsiella pneumoniae from bloodstream infections: Results of a nationwide Italian surveillance study.
The study identified various AMR genes in hypermucoviscous Klebsiella pneumoniae isolates, including bla KPC-3, bla KPC-2, CMY-16, CTX-M-15, bla SHV-2, bla DHA-1, bla CTX-M-65, qnr, aadA1, aac(6')-Ib, sul1, dfrA1, mph(A), erm(B), floR, and fosA3. These genes conferred resistance to multiple antibiotics, including carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and fosfomycin.
Epidemiological characteristics an outbreak of ST11 multidrug-resistant and hypervirulent Klebsiella pneumoniae in Anhui, China.
Detection of β-Lactamase Resistance and Biofilm Genes in Pseudomonas Species Isolated from Chickens.
The study identified the presence of AmpC beta-lactamase genes (blaCMY, blaMIR, DHA, and FOX) in Pseudomonas isolates from chickens, highlighting their role in beta-lactam resistance.
Antibiotic Susceptibility Profiles and Resistance Mechanisms to β-Lactams and Polymyxins of Escherichia coli from Broilers Raised under Intensive and Extensive Production Systems.
The study identifies several β-lactamase genes, including SHV-12, CTX-M group variants, TEM, OXA, and PMAβ, as well as the mcr-1 gene responsible for polymyxin resistance in E. coli isolates from broilers raised in intensive and extensive systems. The prevalence of reduced susceptibility to antibiotics is higher in isolates from the intensive system.
Dissemination of High-Risk Clones Enterobacterales among Bulgarian Fecal Carriage Isolates.
The study identified several AMR genes, including bla CTX-M-15, bla CTX-M-3, bla CTX-M-27, bla CTX-M-14, bla CTX-M-9, bla SHV-1, bla SHV-11, bla TEM-1, bla NDM-1, bla KPC-2, bla CMY-4, bla DHA-1, and bla CMY-2, which confer resistance to various beta-lactam antibiotics. High-risk clones such as ST11, ST258, and ST15 were found to be prevalent among Klebsiella pneumoniae isolates, while ST131 was the most common among E. coli isolates.
Beta-lactamase determinants and molecular typing of carbapenem-resistant classic and hypervirulent Klebsiella pneumoniae clinical isolates from southwest of Iran.
The study identified several beta-lactamase genes, including bla NDM, bla IMP, bla VIM, bla GES, bla OXA-48-like, bla CTX-M, bla SHV, bla TEM, bla FOX, bla DHA, bla CMY, bla LAT, and bla ACT, which are responsible for carbapenem resistance in Klebsiella pneumoniae isolates from southwest Iran.
Klebsiella Species and Enterobacter cloacae Isolates Harboring bla(OXA-181) and bla(OXA-48): Resistome, Fitness Cost, and Plasmid Stability.
The study identified blaOXA-181 and blaOXA-48 genes in Klebsiella species and Enterobacter cloacae isolates, along with blaDHA-1 and qnrB1, highlighting their roles in carbapenem and fluoroquinolone resistance.
Establishing a marine monitoring programme to assess antibiotic resistance: A case study from the Gulf Cooperation Council (GCC) region.
The study identified several AMR genes in E. coli isolates from the GCC marine environment, including bla TEM-1, bla CTX-M-15, qnrS1, tet, sul, and dfr, which conferred resistance to various antibiotics such as ampicillin, cefotaxime, ceftazidime, ciprofloxacin, tetracycline, sulfamethoxazole, and trimethoprim.
Detection of AmpC beta-lactamases in gram-negative bacteria.
The study established a multiplex PCR method to detect six families of AmpC beta-lactamase genes (ACC, EBC, CIT, DHA, MOX, and FOX) in gram-negative bacteria, demonstrating high sensitivity and specificity.
Genomic Characterization of ESBL/AmpC-Producing Escherichia coli in Stray Dogs Sheltered in Yangzhou, China.
The study identified several beta-lactamase genes, including bla CTX-M-15, bla CTX-M-55, and others, along with additional resistance genes such as tet(A), qnrS1, and oqxAB, contributing to multidrug resistance in ESBL/AmpC-producing E. coli isolated from stray dogs in Yangzhou, China.
Expanded catalogue of metagenome-assembled genomes reveals resistome characteristics and athletic performance-associated microbes in horse.
The study identified a diverse array of antibiotic resistance genes (ARG) in the horse gut microbiome, highlighting the widespread use of antibiotics in horse management. The resistome characteristics were analyzed alongside the identification of microbes associated with athletic performance.
Trends of β-Lactamase Occurrence Among Escherichia coli and Klebsiella pneumoniae in United States Hospitals During a 5-Year Period and Activity of Antimicrobial Agents Against Isolates Stratified by β-Lactamase Type.
The study identified various β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-27, bla SHV-12, bla SHV-7, bla SHV-27, bla TEM-1, bla TEM-12, bla CMY-2, bla DHA-1, bla FOX-5, bla OXA-1, bla OXA-1-like, bla KPC-2, bla KPC-3, bla NDM-1, bla NDM-5, bla OXA-181, bla OXA-48, and bla OXA-232, which confer resistance to β-lactam antibiotics. The study also found that CTX-M-15 was the most prevalent β-lactamase gene, and there was a notable increase in ESBL-producing isolates among K. pneumoniae.
Extended-Spectrum β-Lactamase Genes Traverse the Escherichia coli Populations of Intensive Care Unit Patients, Staff, and Environment.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-55, bla CTX-M-14, bla CTX-M-15, bla CTX-M-65, bla CTX-M-27, bla CTX-M-3, bla CTX-M-24, bla CMY-146, bla CMY-2, bla DHA-1, and bla TEM, which are responsible for conferring resistance to multiple beta-lactam antibiotics in Escherichia coli isolates from an ICU setting.
Performance of Phenotypic Tests to Detect beta-lactamases in a Population of beta-lactamase Coproducing Enterobacteriaceae Isolates.
The study identified various beta-lactamase genes including CTX-M, CMY, DHA, ACT, NDM, and OXA-48-like in Enterobacteriaceae isolates. These genes were associated with resistance to multiple β-lactam antibiotics. The performance of phenotypic tests for detecting these resistance mechanisms was evaluated.
Genomic and functional characterization of carbapenem-resistant Klebsiella pneumoniae from hospital wastewater.
The study identified the bla KPC-2 gene as a major contributor to carbapenem resistance in Klebsiella pneumoniae isolates from hospital wastewater, demonstrating its successful in vitro transfer through conjugation.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
Plasmid-mediated colistin resistance among human clinical Enterobacterales isolates: national surveillance in the Czech Republic.
The study identified mcr-1, mcr-4, and mcr-9 genes in colistin-resistant Enterobacterales isolates from the Czech Republic, highlighting their association with plasmid-mediated resistance and multidrug resistance features.
Development and evaluation of a centrifugal disk system for the rapid detection of multiple pathogens and their antibiotic resistance genes in urinary tract infection.
The study developed a centrifugal disk system (LCD) for the rapid detection of multiple pathogens and their antibiotic resistance genes (ARGs) in urinary tract infections (UTIs). The LCD platform demonstrated high specificity and sensitivity for detecting pathogens and ARGs, including beta-lactamases (SHV, TEM, CTX-M-1 group, CTX-M-9 group), carbapenemases (KPC, NDM, IMP, OXA-23, OXA-24, OXA-48), ampC beta-lactamases (DHA, CMY), glycopeptide resistance (VanA), and methicillin resistance (mecA).
Genomic analysis of the initial dissemination of carbapenem-resistant Klebsiella pneumoniae clones in a tertiary hospital.
The study identified the dissemination of carbapenem-resistant Klebsiella pneumoniae clones in a tertiary hospital, highlighting the roles of bla OXA-48, bla NDM-1, bla NDM-23, and bla DHA-1 in carbapenem resistance.
High carriage rate of extended-spectrum β-lactamase Enterobacterales and diarrheagenic Escherichia coli in healthy donor screening for fecal microbiota transplantation.
The study identified a high carriage rate of extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales and diarrheagenic Escherichia coli among healthy donors screened for fecal microbiota transplantation. Key ESBL genes detected include blaCTX-M-79, blaCTX-M-15, blaCMY-2, and blaDHA-1.
Genome-Based Epidemiologic Analysis of VIM/IMP Carbapenemase-Producing Enterobacter spp., Poland.
The study identified multiple bla VIM and bla IMP genes, along with various other AMR genes, in VIM/IMP carbapenemase-producing Enterobacter spp. in Poland. These genes were associated with different integrons and plasmid types, contributing to the spread of multidrug-resistant strains.
In vitro efficacy of humanized regimen of flomoxef against extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae.
Flomoxef showed good bactericidal effects against ESBL-producing E. coli and K. pneumoniae, even with high MIC values. The study identified several CTX-M types (CTX-M-1, CTX-M-9, CTX-M-14, CTX-M-15, CTX-M-28) and AmpC beta-lactamases (DHA, CMY) as significant contributors to resistance.
Impact of acquired broad-spectrum beta-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam beta-lactamase inhibitors in Escherichia coli.
The study evaluates the impact of various beta-lactamases on the susceptibility of Escherichia coli to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and their combinations with beta-lactamase inhibitors avibactam and taniborbactam.
Detection of bla(CTX-M) and bla(DHA) genes in stool samples of healthy people: comparison of culture- and shotgun metagenomic-based approaches.
The study identified bla(CTX-M) and bla(DHA) genes in stool samples of healthy individuals using culture- and shotgun metagenomic sequencing approaches, highlighting the importance of pre-enriched methods for better detection of extended-spectrum cephalosporin-resistant Enterobacterales.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Analyses of Extended-Spectrum-β-Lactamase, Metallo-β-Lactamase, and AmpC-β-Lactamase Producing Enterobacteriaceae from the Dairy Value Chain in India.
The study identified several β-lactamase genes, including bla CMY, bla MOX, bla FOX, bla EBC, bla DHA, bla CTX-M1, bla SHV, bla TEM, bla VIM, bla IMP, bla SPM, bla SIM, and bla GIM, in Enterobacteriaceae isolates from milk samples in India, highlighting the presence of multidrug-resistant bacteria in the dairy value chain.
Nationwide molecular epidemiology of carbapenemase-producing Citrobacter spp. in France in 2019 and 2020.
The study identified various carbapenemase genes, including bla OXA-48, bla NDM-1, bla OXA-181, bla VIM-1, and bla VIM-2, along with aminoglycoside resistance genes such as armA, rmtB1, and rmtC, and polymyxin resistance genes mcr9.1 and mcr9.2 in carbapenemase-producing Citrobacter spp. in France.
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
Molecular Epidemiology of Carbapenem Resistant Klebsiella Pneumoniae in Northern China: Clinical Characteristics, Antimicrobial Resistance, Virulence and Geographic Distribution.
The study identified several carbapenemase genes, including bla NDM-1, bla NDM-5, bla KPC-2, bla OXA-23, bla SME, and bla IMI, as well as extended-spectrum beta-lactamase genes such as bla CTX-M, bla SHV, and bla TEM, and AmpC beta-lactamase gene bla DHA, which contribute to carbapenem resistance in CRKP isolates from Shanxi Province.
Characterization of beta-lactamase producing Enterobacterales isolated from an urban community wastewater treatment plant in Iran.
The study identified various beta-lactamase genes, including bla CTX-M, bla TEM, bla SHV, bla DHA, bla CIT, and bla FOX, in Enterobacterales isolates from a wastewater treatment plant in Iran, highlighting the presence of multidrug-resistant strains.
Prevalence and distribution pattern of AmpC beta-lactamases in ESBL producing clinical isolates of Klebsiella spp. in parts of Assam, India.
The study identifies bla CTX-M, bla CIT, bla DHA, and bla FOX as prevalent AmpC beta-lactamase genes in ESBL-producing Klebsiella spp. isolates in Assam, India, highlighting the co-occurrence of ESBL and AmpC resistance mechanisms.
Comparison of the inoculum effect of in vitro antibacterial activity of Imipenem/relebactam and Ceftazidime/avibactam against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae.
The study evaluated the inoculum effect of Imipenem/relebactam (IMR) and Ceftazidime/avibactam (CZA) against ESBL-, KPC-, and AmpC-producing E. coli and K. pneumoniae. It identified several beta-lactamase genes, including bla TEM-1, bla AmpC, bla CTX-M-14, bla OXA-10, bla CTX-M-55, bla CMY-42, bla CTX-M-15, bla KPC-2, bla OXA-9, bla SHV-182, bla SHV-18, bla OXA-2, bla OKP-B-7, bla DHA-1, bla SHV-27, bla CTX-M-65, bla SHV-11, bla SHV-145, bla SHV-12, bla SHV-106, bla SHV-110, bla SHV106, and bla CTX-M-14, which confer resistance to ceftazidime and/or imipenem.
Emergence and genomic characteristics of multi-drug-resistant Salmonella in pet turtles and children with diarrhoea.
Emergence and genomic characteristics of multi-drug-resistant Salmonella in pet turtles and children with diarrhoea.
Emergence and genomic characteristics of multi-drug-resistant Salmonella in pet turtles and children with diarrhoea.
Human carriage of ESBL/pAmpC-producing Escherichia coli and Klebsiella pneumoniae in relation to the consumption of raw or undercooked vegetables, fruits, and fresh herbs.
The study identified bla CTX-M-15 and bla DHA-1 as the most prevalent ESBL/pAmpC genes in ESBL-E/K isolates from the Dutch population, with no specific raw or undercooked vegetables, fruits, or herbs significantly increasing the risk of ESBL-E/K carriage.
Occurrence and characteristics of extended-spectrum-β-lactamase- and pAmpC-producing Klebsiella pneumoniae isolated from companion animals with urinary tract infections.
The study identified several extended-spectrum beta-lactamase (ESBL) and plasmid-encoded AmpC (pAmpC) genes in Klebsiella pneumoniae isolates from companion animals with urinary tract infections, highlighting the prevalence of these resistance mechanisms.
Genotypic Characterization of Uropathogenic Escherichia coli from Companion Animals: Predominance of ST372 in Dogs and Human-Related ST73 in Cats.
The study identified several AMR genes and mutations in uropathogenic E. coli isolates from companion animals, including blaTEM-1B, sul2, tet(A), qnrS1, aac(6')-Ib-c, qnrS2, qnrB19, qnrB4, CTX-M-15, CTX-M-27, CMY-2, DHA-1, blaEC, blaEC-6, and mcr-4.6. Mutations in gyrA (S83L, D87N) and parC (S80I) were also found to confer fluoroquinolone resistance.
Whole genome sequence-based molecular characterization of blood isolates of carbapenem-resistant Enterobacter cloacae complex from ICU patients in Kolkata, India, during 2017-2022: emergence of phylogenetically heterogeneous Enterobacter hormaechei subsp. xiangfangensis.
The study identified several carbapenemase and extended-spectrum beta-lactamase genes, including bla NDM-1, bla NDM-4, bla NDM-5, bla NDM-7, bla OXA-181, bla OXA-232, bla KPC-3, bla CTX-M-15, bla SFO-1, bla ACT, and bla CMH-3, in carbapenem-resistant Enterobacter cloacae complex isolates from Kolkata, India. Novel integrons (In180, In4874, In4887, and In4888) were also discovered.
Outbreak of NDM-5-producing Klebsiella pneumoniae ST307: an emerging high-risk antimicrobial resistance clone in Shanghai, China.
The study reports an outbreak of NDM-5-producing Klebsiella pneumoniae ST307 in Shanghai, China, highlighting the presence of multiple resistance genes including bla NDM-5, bla CTX-M-15, and bla DHA-1, which confer resistance to carbapenems, cephalosporins, and other antibiotics.
Transferable AmpCs in Klebsiella pneumoniae: interplay with peptidoglycan recycling, mechanisms of hyperproduction, and virulence implications.
The study identifies blaDHA-1 and blaCMY-2 as transferable AmpC beta-lactamases in Klebsiella pneumoniae, highlighting their roles in beta-lactam resistance and the potential for hyperproduction through chromosomal mutations, particularly in mpl.
Rare Plasmid-Mediated AmpC Beta-Lactamase DHA-1 Located on Easy Mobilized IS26-Related Genetic Element Detected in Escherichia coli from Livestock and Food in Germany.
The study identified the rare plasmid-mediated AmpC beta-lactamase DHA-1 in E. coli isolates from livestock and food in Germany, highlighting its presence on IS26-related genetic elements and its association with multiple resistance genes.
What Contributes to the Minimum Inhibitory Concentration? Beyond beta-lactamase Gene Detection in Klebsiella pneumoniae.
The study highlights the complex interplay between beta-lactamases and outer membrane porins in determining β-lactam resistance in Klebsiella pneumoniae. Plasmid-encoded beta-lactamases such as CTX-M-14, CTX-M-15, CMY-2, and DHA-1, as well as chromosomal SHV-5, were found to confer resistance to various β-lactam antibiotics. Additionally, loss of outer membrane porins OmpK35, OmpK36, and PhoE was associated with meropenem resistance.
High prevalence of multidrug-resistant Enterobacterales carrying extended-spectrum beta-lactamase and AmpC genes isolated from neonatal sepsis in Ahvaz, Iran.
The study identified a high prevalence of multidrug-resistant Enterobacterales carrying extended-spectrum beta-lactamase (ESBL) and AmpC genes, with bla CTX-M−15 being the most common ESBL gene.
Resistome Analysis of Klebsiella pneumoniae Complex from Residential Aged Care Facilities Demonstrates Intra-facility Clonal Spread of Multidrug-Resistant Isolates.
The study identified several AMR genes and mutations in K. pneumoniae isolates from RACFs, including beta-lactamases (bla DHA-1, bla SHV-1, bla SHV-27, bla CTX-M-14), fluoroquinolone resistance determinant qnrB4, and trimethoprim-sulfamethoxazole resistance determinants dfrA17 and sul1. Mutations in ompK35, ompK37, prmA, pmrB, eptA, and parC were also found to contribute to resistance.
Novel Providencia xianensis sp. nov.: A multidrug-resistant species identified in clinical infections.
The study identifies a novel multidrug-resistant species, Providencia xianensis, which shows resistance to several antibiotics including tetracycline, trimethoprim/sulfamethoxazole, lincosamide, rifamycin, and beta-lactams.
Assessment of three antibiotic combination regimens against Gram-negative bacteria causing neonatal sepsis in low- and middle-income countries.
The study identifies multiple AMR genes and mutations in Gram-negative bacteria causing neonatal sepsis in LMICs, including ESBLs, carbapenemases, and aminoglycoside-modifying enzymes, highlighting the high prevalence of multidrug resistance and the need for effective antibiotic combinations.
Genomic analysis of multidrug-resistant Escherichia coli from Urban Environmental water sources in Accra, Ghana, Provides Insights into public health implications.
The study identified several AMR genes in multidrug-resistant E. coli isolates from urban environmental water sources in Accra, Ghana, highlighting the presence of beta-lactamases (blaTEM-1B, blaCTX-M-15, blaTEM-1C, blaDHA-1, blaOXA-1, blaOXA-181), sulfonamide resistance genes (sul2, sul1), aminoglycoside resistance genes (aph(6)-Id, aadA2, mph(A)), quinolone resistance gene (qnrS1), tetracycline resistance gene (tet(B)), chloramphenicol resistance gene (catA1), dihydrofolate reductase (dfrA14), and others.
Genomic characterisation of Escherichia coli isolated from poultry at retail through Sink Surveillance in Dhaka, Bangladesh reveals high levels of multi-drug resistance.
The study identified multiple AMR genes in E. coli isolates from poultry in Bangladesh, including genes conferring resistance to various antibiotics such as tetracycline, ciprofloxacin, azithromycin, colistin, and others. High levels of multidrug resistance were observed, with specific genes like mcr1.1, bla CTX-M-65, and tet(A) playing significant roles.
Nanopore R10.4 metagenomic detection of bla(CTX-M)/bla(DHA) antimicrobial resistance genes and their genetic environments in stool.
The study evaluates the use of Nanopore-SMS for detecting bla CTX-M and bla DHA genes in stool samples, demonstrating that pre-enriched Nanopore-SMS improves sensitivity and detects these genes in plasmid and chromosomal environments.
Carriage Rate of Enterobacterales Resistant to Extended-Spectrum Cephalosporins in the Tunisian Population.
The study identified bla CTX-M-15 and bla DHA-1 as the primary genes conferring resistance to extended-spectrum cephalosporins in Enterobacterales isolated from healthy Tunisian individuals. Additional resistance mechanisms included aminoglycoside, sulfonamide, tetracycline, and quinolone resistance genes.
An in-depth study on survival mechanism of bacterial isolates in disinfectants within the hospital environment.
The study identified multiple AMR genes, including blaDIM-1, qacE, and various efflux pump genes, in bacterial isolates from hospital disinfectants, indicating their adaptation to survive in disinfectant environments.
Investigation on the mechanisms of carbapenem resistance among the non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae.
The study identified non-carbapenemase β-lactamase genes and chromosomal mutations, including missense mutation or loss of ompK36 porin and frameshift missense mutation in efflux pump systems, as potential mechanisms of carbapenem resistance in NC-CRKP.
Relative inhibitory activities of newly developed diazabicyclooctanes, boronic acid derivatives, and penicillin-based sulfone beta-lactamase inhibitors against broad-spectrum AmpC beta-lactamases.
The study evaluates the inhibitory activities of various beta-lactamase inhibitors against a wide range of AmpC beta-lactamases, identifying the effectiveness of certain inhibitors like durlobactam and zidebactam in reducing the MIC values of β-lactam antibiotics against AmpC-producing strains.
Molecular epidemiological analysis of bla(NDM-5)-producing Klebsiella pneumoniae ST2407-K25 causing infection outbreaks in pediatric patients based on whole genome sequencing.
The study identifies bla_NDM-5 as the primary carbapenem resistance gene in CRKP ST2407-K25 isolates, along with additional resistance genes such as bla_DHA-1, bla_SHV-1, bla_CTX-M-14, qnrB4, sul1, and qacEΔ1. Mutations in ramR and acrR are linked to tigecycline resistance.
Genomic Characterization of 16S rRNA Methyltransferase-Producing Enterobacterales Reveals the Emergence of Klebsiella pneumoniae ST6260 Harboring rmtF, rmtB, bla(NDM-5), bla(OXA-232) and bla(SFO-1) Genes in a Cancer Hospital in Bulgaria.
The study identifies the emergence of Klebsiella pneumoniae ST6260 harboring multiple AMR genes, including rmtF, rmtB, bla(NDM-5), bla(OXA-232), and bla(SFO-1), highlighting the complexity of resistance mechanisms in Enterobacterales.
Interrelation Between Pathoadaptability Factors and Crispr-Element Patterns in the Genomes of Escherichia coli Isolates Collected from Healthy Puerperant Women in Ural Region, Russia.
The study identified several AMR genes in E. coli isolates from healthy puerperant women, including beta-lactamases (bla CTX-M-15, bla TEM-1C, bla DHA-1, bla CTX-M-27, bla TEM-1B, bla OXA-1), aminoglycoside resistance genes (aadA5, dfrA17), and a fosfomycin resistance gene (fosA).
AmpC beta-lactamases detected in Southeast Asian Escherichia coli and Klebsiella pneumoniae.
The study identifies various beta-lactamase genes, including bla CMY-2, bla CMY-42, bla DHA-1, bla NDM-5, bla OXA-1, and bla TEM-1, which confer resistance to multiple antibiotics in Escherichia coli and Klebsiella pneumoniae isolates from Southeast Asia.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Antibiotic Resistance Genes and Microbiota in Brassica oleracea var. acephala Cultivated in South Korea: Potential for Resistance Transmission.
The study identified several beta-lactam resistance genes, including blaCTX-M-8, blaCTX-M-14, blaNDM, and blaDHA, in Klebsiella pneumoniae isolates from kale. These genes were shown to confer resistance to ampicillin and ceftazidime through conjugation experiments and MIC measurements.
Molecular epidemiology of beta-lactamases in ceftriaxone-resistant Enterobacterales bloodstream infections in the mid-Atlantic United States.
The study identified various beta-lactamase genes including bla CTX-M, bla SHV, bla OXY, bla VEB, bla CMY-59, and bla DHA-1 in ceftriaxone-resistant Enterobacterales. Additionally, mutations in the promoter or attenuator regions of the c-ampC gene in E. coli were investigated, but they did not significantly contribute to ceftriaxone resistance.
Molecular analysis of AmpC-producing Escherichia coli isolated from pediatric patients.
The study identified plasmid-mediated AmpC genes blaDHA-1 and blaCMY-2, as well as chromosomal ampC mutations in pediatric E. coli isolates, contributing to cephalosporin resistance.
Prevalence of β-lactam antibiotic resistance of Escherichia coli isolated from a neonatal intensive care unit.
The study identified several β-lactam resistance genes, including bla KPC-2, bla CTX-M-64, bla CTX-M-65, bla TEM-1, bla OXA-1, and bla DHA-1, in Escherichia coli isolates from a neonatal intensive care unit. These genes were found to confer resistance to various β-lactam antibiotics.
Genomic analysis of Enterobacter cloacae complex from Southern Thailand reveals insights into multidrug resistance genotypes and genetic diversity.
The study identified multiple antimicrobial resistance genes in Enterobacter cloacae complex isolates from Southern Thailand, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and efflux pumps. Notably, the mcr-9 gene was found to confer colistin resistance.
Tracing the evolution: the rise of Salmonella Thompson co-resistant to clinically important antibiotics in China, 1997-2020.
The study identifies the IncC plasmid as a major driver of co-resistance to ciprofloxacin, cefotaxime, and azithromycin in Salmonella Thompson isolates in China, with specific resistance genes including qnrS1, qepA4, blaCMY-2, and mph(A).
The rise in domestic shigellosis and the genomic characteristics of Shigella clones linked to men who have sex with men in Taiwan, 2015‒2022.
The study identifies several AMR genes and mutations in Shigella clones associated with men who have sex with men (MSM) in Taiwan, highlighting the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains.
Genomic epidemiology and antimicrobial resistance of Morganella clinical isolates between 2016 and 2023.
The study identified several AMR genes in Morganella clinical isolates, including tet(B), sul1, catA2, sul2, floR, aadA1, and others, contributing to resistance against various antibiotics.
Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.
This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.
Next-generation diagnostics of bloodstream infections enabled by rapid whole-genome sequencing of bacterial cells purified from blood cultures.
The study presents a rapid whole-genome sequencing workflow (LC-WGS) for diagnosing bloodstream infections, demonstrating accurate identification of bacterial pathogens and detection of clinically relevant resistance markers within 4.2 hours. The workflow successfully identified various AMR genes, including bla CTX-M-15, bla DHA-1, bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-23, armA, mecA, vanRSHAXYZ, aac(6')-Ie/aph(2'')-Ia, aph(3')-IIIa, aac(6')-I, sul1, and dfrA17.
Rapid prediction of carbapenemases in Pseudomonas aeruginosa by imipenem/relebactam and MALDI-TOF MS.
The study characterizes various carbapenemase genes such as blaIMP-13, blaIMP-94, blaNDM-1, blaNDM-5, blaNDM-7, blaNDM-23, blaVIM-1, blaVIM-2, blaVIM-20, blaKPC-2, blaKPC-3, blaGES-1, blaGES-5, blaGES-7, blaGES-20, blaPER-1, blaVEB-1, blaCTX-M-15, blaCTX-M-9, blaSHV-12, blaFOX-4, blaCMY-2, blaDHA-1, blaOXA-2, blaOXA-10, blaOXA-14, blaOXA-15, and blaOXA-48 in Pseudomonas aeruginosa using MALDI-TOF MS hydrolysis assays.
Genomic characterization of extended-spectrum beta-lactamase-producing Escherichia coli spread among chickens and healthy residents in Lombok, Indonesia.
The study identifies bla CTX-M-55, bla CTX-M-15, bla CTX-M-1, bla CMY-2, and bla DHA-1 as the most prevalent extended-spectrum beta-lactamase genes in E. coli isolates from chickens and humans in Lombok, Indonesia. Additionally, the study characterizes a 200 kb IncHI1 plasmid carrying multiple resistance genes, including aac(3)-IId, aph(6)-Id, aph(3’’)-Ib, aadA17, mph(A), Inu(F), qnrS1, sul2, and dfrA14, contributing to multidrug resistance.
Characterization of phenotypic and genotypic traits of Klebsiella pneumoniae strains resistant to 3rd generation cephalosporins in hospital settings: A case study in Ho Chi Minh City, Vietnam.
The study identifies the prevalence of AmpC beta-lactamase, ESBL, and carbapenemase genes in Klebsiella pneumoniae isolates from Ho Chi Minh City, Vietnam, highlighting the high resistance rates to third-generation cephalosporins and carbapenems.
Extended spectrum beta-lactamase producing Escherichia coli and antimicrobial resistance gene sharing at the interface of human, poultry and environment: results of ESBL tricycle surveillance in Kathmandu, Nepal.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla CTX-M-27, bla CTX-M-14, bla CMY-148, bla CMY-2, bla CMY-4, bla DHA-1, bla OXA-1, bla OXA-9, bla NDM-5, bla TEM-1, bla TEM-135, bla TEM-176, bla TEM-190, and the polymyxin resistance gene mcr-1 in ESBL-producing E. coli isolates from human, poultry, and environmental sources in Kathmandu, Nepal.
The First Case of Antimicrobial-Resistant Salmonella Stanley ST29 Diagnosed Secondary to Acute Cholecystitis.
The study identifies multiple antimicrobial resistance genes in Salmonella Stanley ST29, including beta-lactamases, quinolone resistance genes, macrolide resistance genes, and others, contributing to resistance against various antibiotics.
Mapping Antimicrobial Resistance in Escherichia coli and Klebsiella pneumoniae from Complicated Urinary Tract Infections in Oman: Phenotypic and Genotypic Insights.
The study identified blaDHA-1 as the predominant AmpC gene in E. coli and blaOXA-232 and blaNDM-5 as the primary carbapenemases in K. pneumoniae. Additionally, various other resistance genes such as blaCTX-M-15, blaOXA-1, blaTEM-1B, qnrB4, aac(6')-Ib, and armA were characterized.
Broadly reactive monoclonal antibodies against beta-lactamases for immunodetection of bacterial resistance to antibiotics.
The study describes broadly reactive monoclonal antibodies (MAbs) against AmpC beta-lactamases, which are key enzymes in bacterial resistance to beta-lactam antibiotics. These MAbs recognize a conserved epitope of 11 amino acids and show cross-reactivity with various AmpC beta-lactamases, including DHA-1, CMY-34, ACT-14, PDC-195, and ADC-144.
Establishing Clinical and Laboratory Standards Institute M45 antimicrobial susceptibility testing methods and breakpoints for Pseudomonas other than Pseudomonas aeruginosa.
The study established tentative CLSI M45 antimicrobial susceptibility testing breakpoints for Pseudomonas other than Pseudomonas aeruginosa (POPA). It identified various beta-lactamase genes, including metallo-beta-lactamases (MBLs) such as bla POM-1, bla POM-2, bla PAM-1, bla PST-1, bla VIM-2, bla CARB-2, bla DHA-1, and bla IMP-13, which confer resistance to carbapenems. Additionally, multidrug-resistant efflux pumps like ttgABC and tmexCD-toprJ were found to contribute to carbapenem resistance. Other resistance genes for aminoglycosides, trimethoprim-sulfamethoxazole, quaternary ammonium compounds, chloramphenicol, and fluoroquinolones were also detected.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Massive culture-based approach for the screening of AmpC, ESBL, and carbapenemase producers from rectal swabs.
The study presents a massive culture-based approach for the screening of AmpC, ESBL, and carbapenemase producers from rectal swabs, demonstrating improved specificity for detecting ESBL producers compared to conventional methods. It identifies various beta-lactamase genes, including bla CTX-M-1/2-like, bla CTX-M-8-like, bla CTX-M-9-like, bla SHV-like, bla TEM-like, bla GES-like, bla MOX, bla CIT, bla DHA, bla ACC, bla EBC, bla FOX, bla CMY-2, and bla NDM.
Should Cefoxitin Non-Susceptibility in Ceftriaxone-Susceptible E. coli and K. pneumoniae Prompt Concerns Regarding Plasmid-Mediated AmpC Resistance? A Genomic Characterization and Summary of Treatment Challenges in Singapore.
The study found that only 13.9% of cefoxitin-non-susceptible isolates harbored plasmid-mediated ampC, specifically the blaDHA-1 subtype. Additionally, ampR, a transcriptional regulator, was present in all ampC-positive isolates. Five K. pneumoniae isolates showed truncations in ompK35 and ompK36, which may contribute to reduced cefoxitin susceptibility.
Isolation and Molecular Characterization of Antimicrobial-Resistant Bacteria from Vegetable Foods.
The study identified several antimicrobial resistance genes in Enterobacteriaceae isolated from vegetables, including TEM, CTX-M IV, SHV, OXA, CMY II, DHA, tetA, tetW, sul-I, and qnrD, which confer resistance to beta-lactams, tetracyclines, sulfonamides, and quinolones.
Metagenomic analysis after selective culture enrichment of hospital and community wastewater enhances antimicrobial resistance gene detection.
The study identifies various beta-lactamase genes such as bla CTX-M, bla KPC, bla NDM, and bla VIM, along with other resistance genes like erm(TR), lsa, efrA, efrB, and optrA, which were detected through selective culture enrichment of wastewater samples.
Navigating an evolving microbial landscape: emerging antimicrobial resistance trends and precision stewardship in Tianjin tertiary hospitals (2021-2023).
The study identified significant trends in antimicrobial resistance (AMR) patterns among clinical isolates from hospitals in Tianjin, highlighting the increasing resistance of Klebsiella pneumoniae to various antibiotics, including carbapenems, and the notable decline in ceftazidime/avibactam resistance in E. coli. Additionally, it noted the emergence of resistance in Acinetobacter baumannii and Pseudomonas aeruginosa to several antimicrobials.
Persistent multispecies dissemination of armA-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital.
The study identifies the persistent dissemination of armA-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital, highlighting the role of these plasmids in the spread of aminoglycoside resistance.
Rapid detection of gram-negative antimicrobial resistance determinants directly from positive blood culture broths using a multiplex PCR system.
The study evaluated the BIOFIRE FILMARRAY Antimicrobial Resistance (AMR) Panel for rapid detection of AMR genes in gram-negative bacteria from positive blood culture broths. It identified several AMR genes, including beta-lactamases (TEM-1, SHV-1, CTX-M, KPC, NDM, OXA-1, OXA-23), AmpC beta-lactamases (CMY/MOX, DHA), aminoglycoside modifying enzymes (AAC(6′)-Ib-cr), and fluoroquinolone resistance mutations (ParC-S80I, GyrA-S83F/I/L).
Genomic and epidemiological characteristics of Shigella boydii in Australia, 1991-2022.
The study identified high levels of antimicrobial resistance in Shigella boydii, with over 60% of isolates classified as multidrug-resistant. Key resistance genes included blaCTX-M-15, blaCTX-M-3, blaDHA-1, mphA, sul1, sul2, dfrA1, dfrA14, dfrA5, dfrA12, dfrA17, dfrA7, aadA1, aph(3’’)-Ib, aph(6)-Id, tet(A), and tet(B). Mutations in gyrA and parC were associated with ciprofloxacin resistance and reduced susceptibility.
AgNPs treatment reduces time recovery and increases bacterial sensitivity to antibiotics in cow´s purulent catarrhal endometritis. A translational study.
The study found that Argovit-C treatment reduced the prevalence of blaGES and blaDHA resistance genes in E. coli isolates from cows with purulent catarrhal endometritis, indicating a potential to limit the spread of antibiotic resistance.
Genomic epidemiology of strains currently and formerly classified as Enterobacter spp. recovered from equine necropsy samples.
The study identified several AMR genes in Enterobacter spp. strains, including beta-lactamases (blaDHA-1, blaOXA-1, blaSHV-12, blaTEM-1B), aminoglycoside resistance genes (aac(6')-ib_cr), quinolone resistance genes (qnrB2, qnrB4), and fosfomycin resistance genes (fosA, fosA2). These genes contribute to resistance against multiple antibiotic classes.
Genomic characterization of Klebsiella pneumoniae clinical isolates from cancer patients: resistance profiles, virulence factors, and sequence typing.
The study identified several AMR genes in K. pneumoniae isolates from cancer patients, including genes conferring resistance to trimethoprim-sulfamethoxazole, tobramycin, levofloxacin, and carbapenems. Key resistance genes included sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA27, aadA16, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aph(4)-Ia, ACC(3)-IId, ACC(3)-IIV, AAC(6')-Ib-cr, QnrS1, QnrB17, QnrB20, QnrB4, CTX-M, SHV, TEM, DHA-1, LAP-2, bla_kpc-1, bla_ndm-5, and bla_oxa-10.
Frequency of Pseudomonas's Antibiotic Resistance and Virulence Genes in Poultry Meat.
The study identified several antibiotic resistance genes, including bla TEM, bla SHV, bla DHA, and others, in Pseudomonas aeruginosa isolates from poultry meat. Additionally, various virulence genes such as exoT, exoY, exoS, and exoU were detected.
Virulence and Antibiotic Resistance Profiles of Proteus mirabilis Strains Isolated From Broiler Chickens: Implications for Poultry and Public Health.
The study identified blaTEM and blaDHA genes in P. mirabilis isolates from broiler chickens, which confer resistance to various beta-lactam antibiotics. High resistance rates were observed against chloramphenicol and trimethoprim/sulfamethoxazole, while all isolates were susceptible to meropenem and cefepime.
Ultrasound-Assisted Extraction: Unlocking the Antibacterial Potential of Coptis chinensis Franch. Against ESBL-Producing Enterobacterales.
The study identifies multiple beta-lactamase resistance genes in ESBL-PE strains, including blaCTX-M-14, blaCTX-M-1, blaCTX-M-3, blaCTX-M-15, blaCTX-M-65, blaSHV, blaTEM, blaEC, blaACC, blaCMY, blaACT, blaDHA, and efflux pump genes such as acrF, emrD, mdtM, silA, kdeA, oqxA, oqxB, arsB, oqxA10, oqxB5, oqxB19, arsA, and hugA, which contribute to multidrug resistance in these isolates.
A Monitoring Method to Evaluate the Accumulation of Antimicrobial-Resistance Genes in Gram-Negative Bacteria Distributed in Environmental Water.
The study identified multiple antimicrobial resistance genes (ARGs) in Gram-negative bacteria isolated from environmental water samples, including bla NDM-5, bla CTX-M-27, bla DHA-1, and others, indicating the presence of carbapenem-resistant and extended-spectrum beta-lactamase-producing bacteria in the Vietnamese VAC ecosystem.
Prevalence of ESBL-Producing Escherichia coli on Neck Skin in Slaughtered Broilers Raised on Conventional, Antibiotic-Free, and Organic Farms.
The study identified various ESBL and AmpC genes, including bla CTX-M-1, bla CTX-M-9, bla TEM, bla SHV, bla OXA, bla CIT, bla MOX, bla DHA, bla ACC, bla EBC, and bla FOX, in ESBL-producing E. coli isolates from broiler neck skin. These genes were associated with resistance to beta-lactam antibiotics such as cefotaxime, ceftazidime, and cefoxitin.
Cloning and sequencing of the gene encoding the AmpC beta-lactamase of Morganella morganii.
Salmonella enteritidis: AmpC plasmid-mediated inducible beta-lactamase (DHA-1) with an ampR gene from Morganella morganii.
The study identifies DHA-1, a plasmid-mediated inducible AmpC beta-lactamase from Salmonella enteritidis, which confers resistance to cephalosporins and cephamycins. The ampR gene from Morganella morganii was found to regulate this enzyme.
Salmonella enteritidis: AmpC plasmid-mediated inducible beta-lactamase (DHA-1) with an ampR gene from Morganella morganii.
Salmonella enteritidis: AmpC plasmid-mediated inducible beta-lactamase (DHA-1) with an ampR gene from Morganella morganii.
Salmonella enteritidis: AmpC plasmid-mediated inducible beta-lactamase (DHA-1) with an ampR gene from Morganella morganii.
Salmonella enteritidis: AmpC plasmid-mediated inducible beta-lactamase (DHA-1) with an ampR gene from Morganella morganii.
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