Browse AMR Genes

Gene Information

Gene Name: blaGES
Allele: blaGES-29
Encodes: class A beta-lactamase GES-29
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KT997885.1
Protein Accession: ALM96712.1
Notes: ARO:3006158

Gene Information

Gene Name: blaGES
Allele: blaGES-29
Encodes: class A beta-lactamase GES-29
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KT997885.1
Protein Accession: ALM96712.1
Notes: ARO:3006158

Gene Information

Gene Name: blaGES
Allele: blaGES-34
Encodes: class A beta-lactamase GES-34
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MG748726.1
Protein Accession: AUM56802.1
Notes: ARO:3006163

Gene Information

Gene Name: blaGES
Allele: blaGES-34
Encodes: class A beta-lactamase GES-34
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MG748726.1
Protein Accession: AUM56802.1
Notes: ARO:3006163

Gene Information

Gene Name: blaGES
Allele: blaGES-35
Encodes: class A beta-lactamase GES-35
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Acinetobacter baumannii
Sequence Accession: MH388469.1
Protein Accession: AWN81339.1
Notes: ARO:3006164

Gene Information

Gene Name: blaGES
Allele: blaGES-35
Encodes: class A beta-lactamase GES-35
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Acinetobacter baumannii
Sequence Accession: MH388469.1
Protein Accession: AWN81339.1
Notes: ARO:3006164

Gene Information

Gene Name: blaGES
Allele: blaGES-36
Encodes: class A beta-lactamase GES-36
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: LC385763.1
Protein Accession: BBE28626.1
Notes: ARO:3006165

Gene Information

Gene Name: blaGES
Allele: blaGES-36
Encodes: class A beta-lactamase GES-36
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: LC385763.1
Protein Accession: BBE28626.1
Notes: ARO:3006165

Gene Information

Gene Name: blaGES
Allele: blaGES-37
Encodes: class A beta-lactamase GES-37
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: LC385764.1
Protein Accession: BBE28627.1
Notes: ARO:3006166

Gene Information

Gene Name: blaGES
Allele: blaGES-37
Encodes: class A beta-lactamase GES-37
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: LC385764.1
Protein Accession: BBE28627.1
Notes: ARO:3006166

Gene Information

Gene Name: blaGES
Allele: blaGES-42
Encodes: class A beta-lactamase GES-42
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MN065796.1
Protein Accession: QDC28519.1
Notes: ARO:3006171

Gene Information

Gene Name: blaGES
Allele: blaGES-42
Encodes: class A beta-lactamase GES-42
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MN065796.1
Protein Accession: QDC28519.1
Notes: ARO:3006171

Gene Information

Gene Name: blaGES
Allele: blaGES-43
Encodes: class A beta-lactamase GES-43
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MN219691.1
Protein Accession: QDY98368.1
Notes: ARO:3006172

Gene Information

Gene Name: blaGES
Allele: blaGES-43
Encodes: class A beta-lactamase GES-43
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MN219691.1
Protein Accession: QDY98368.1
Notes: ARO:3006172

Gene Information

Gene Name: blaGES
Allele: blaGES-46
Encodes: class A beta-lactamase GES-46
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MW295358.1
Protein Accession: QPN97000.1
Notes: ARO:3006175

Gene Information

Gene Name: blaGES
Allele: blaGES-46
Encodes: class A beta-lactamase GES-46
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MW295358.1
Protein Accession: QPN97000.1
Notes: ARO:3006175

Gene Information

Gene Name: blaGES
Allele: blaGES-55
Encodes: class A beta-lactamase GES-55
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: AVIBACTAMCEPHALOSPORIN
Organisms Tested In: • Serratia marcescens
Sequence Accession: ON714048.1
Protein Accession: UUF81220.1
Notes: ARO:3007833

Gene Information

Gene Name: blaGES
Allele: blaGES-55
Encodes: class A beta-lactamase GES-55, GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: AVIBACTAMCEPHALOSPORIN
Organisms Tested In: • Serratia marcescens
Sequence Accession: ON714048.1
Protein Accession: UUF81220.1
Notes: ARO:3007833

Gene Information

Gene Name: blaGES
Allele: blaGES-56
Encodes: class A beta-lactamase GES-56
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Acinetobacter baumannii
Sequence Accession: OP158701.1
Protein Accession: UUT09019.1
Notes: ARO:3007834

Gene Information

Gene Name: blaGES
Allele: blaGES-56
Encodes: class A beta-lactamase GES-56, GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Acinetobacter baumannii
Sequence Accession: OP158701.1
Protein Accession: UUT09019.1
Notes: ARO:3007834

Gene Information

Gene Name: blaGES
Allele: blaGES-57
Encodes: class A beta-lactamase GES-57
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: OP716785.1
Protein Accession: UYS49421.1
Notes: ARO:3007835

Gene Information

Gene Name: blaGES
Allele: blaGES-57
Encodes: class A beta-lactamase GES-57, GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: OP716785.1
Protein Accession: UYS49421.1
Notes: ARO:3007835

Gene Information

Gene Name: blaGES
Allele: blaGES-58
Encodes: class A beta-lactamase GES-58
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Enterobacter asburiae
Sequence Accession: LC763412.1
Protein Accession: BED98385.1
Notes: ARO:3008185

Gene Information

Gene Name: blaGES
Allele: blaGES-58
Encodes: class A beta-lactamase GES-58, GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Enterobacter asburiae
Sequence Accession: LC763412.1
Protein Accession: BED98385.1
Notes: ARO:3008185

Gene Information

Gene Name: blaGES
Allele: blaGES-59
Encodes: class A beta-lactamase GES-59
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: OQ813783.1
Protein Accession: WGG88839.1
Notes: ARO:3008186

Gene Information

Gene Name: blaGES
Allele: blaGES-59
Encodes: class A beta-lactamase GES-59, GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: OQ813783.1
Protein Accession: WGG88839.1
Notes: ARO:3008186

Gene Information

Gene Name: blaGES
Allele: blaGES-60
Encodes: extended-spectrum class A beta-lactamase GES-60
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PP695362.1
Protein Accession: WZW61385.1
Notes: ARO:3008187

Gene Information

Gene Name: blaGES
Allele: blaGES-60
Encodes: extended-spectrum class A beta-lactamase GES-60, GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PP695362.1
Protein Accession: WZW61385.1
Notes: ARO:3008187

Gene Information

Gene Name: blaGES
Allele: blaGES-61
Encodes: carbapenem-hydrolyzing class A beta-lactamase GES-61
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Aeromonas caviae
Sequence Accession: JAYGON010000276.1
Protein Accession: MEA9429459.1
Notes: ARO:3008188

Gene Information

Gene Name: blaGES
Allele: blaGES-61
Encodes: carbapenem-hydrolyzing class A beta-lactamase GES-61, GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Aeromonas caviae
Sequence Accession: JAYGON010000276.1
Protein Accession: MEA9429459.1
Notes: ARO:3008188

Gene Information

Gene Name: blaGES
Allele: blaGES-62
Encodes: class A beta-lactamase GES-62
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PQ117759.1
Protein Accession: XFH17877.1
Notes: ARO:3008189

Gene Information

Gene Name: blaGES
Allele: blaGES-62
Encodes: class A beta-lactamase GES-62, GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PQ117759.1
Protein Accession: XFH17877.1
Notes: ARO:3008189

Gene Information

Gene Name: blaGES
Allele: blaGES-65
Encodes: class A beta-lactamase GES-65
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PQ394547.1
Protein Accession: XHO32890.1
Notes: ARO:3008190

Gene Information

Gene Name: blaGES
Allele: blaGES-65
Encodes: class A beta-lactamase GES-65, GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PQ394547.1
Protein Accession: XHO32890.1
Notes: ARO:3008190

Gene Information

Gene Name: blaGES
Allele: blaGES-66
Encodes: carbapenem-hydrolyzing class A beta-lactamase GES-66
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: CP173044.1
Protein Accession: XLJ41066.1
Notes: ARO:3008191

Gene Information

Gene Name: blaGES
Allele: blaGES-66
Encodes: carbapenem-hydrolyzing class A beta-lactamase GES-66
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: CP173044.1
Protein Accession: XLJ41066.1
Notes: ARO:3008191

Gene Information

Gene Name: blaGES
Allele: blaGES-67
Encodes: class A beta-lactamase GES-67
Source Database: Reference Gene Catalog
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PV088249.1
Protein Accession: XPD12781.1

Gene Information

Gene Name: blaGES
Allele: blaGES-68
Encodes: class A beta-lactamase GES-68
Source Database: Reference Gene Catalog
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PX238429.1
Protein Accession: YAJ19486.1

Gene Information

Gene Name: blaGES
Allele: blaGES-69
Encodes: class A beta-lactamase GES-69
Source Database: Reference Gene Catalog
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PX278758.1
Protein Accession: YAB40485.1

Gene Information

Gene Name: blaGES
Allele: blaGES-70
Encodes: class A beta-lactamase GES-70
Source Database: Reference Gene Catalog
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PX654923.1
Protein Accession: YCB24323.1

Gene Information

Gene Name: blaGES
Allele: blaGES-25
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Citrobacter freundii
Sequence Accession: NG_049128.1
Protein Accession: WP_063860510.1
Notes: ARO:3003185

Gene Information

Gene Name: blaGES
Allele: blaGES-27
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_049130.1
Protein Accession: WP_063860512.1
Notes: ARO:3006156

Gene Information

Gene Name: blaGES
Allele: blaGES-28
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_049131.1
Protein Accession: WP_063860513.1
Notes: ARO:3006157

Gene Information

Gene Name: blaGES
Allele: blaGES-29
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_049132.1
Protein Accession: WP_063860514.1
Notes: ARO:3006158

Gene Information

Gene Name: blaGES
Allele: blaGES-30
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_049134.1
Protein Accession: WP_063860516.1
Notes: ARO:3006159

Gene Information

Gene Name: blaGES
Allele: blaGES-31
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Aeromonas caviae
Sequence Accession: NG_049135.1
Protein Accession: WP_063860517.1
Notes: ARO:3006160

Gene Information

Gene Name: blaGES
Allele: blaGES-32
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_051512.1
Protein Accession: WP_069280709.1
Notes: ARO:3006161

Gene Information

Gene Name: blaGES
Allele: blaGES-33
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_054709.1
Protein Accession: WP_085562419.1
Notes: ARO:3006162

Gene Information

Gene Name: blaGES
Allele: blaGES-34
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_056177.1
Protein Accession: WP_102607460.1
Notes: ARO:3006163

Gene Information

Gene Name: blaGES
Allele: blaGES-35
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Acinetobacter baumannii
Sequence Accession: NG_060520.1
Protein Accession: WP_111273848.1
Notes: ARO:3006164

Gene Information

Gene Name: blaGES
Allele: blaGES-36
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_060521.1
Protein Accession: WP_111273849.1
Notes: ARO:3006165

Gene Information

Gene Name: blaGES
Allele: blaGES-37
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_060522.1
Protein Accession: WP_111273850.1
Notes: ARO:3006166

Gene Information

Gene Name: blaGES
Allele: blaGES-38
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_062215.1
Protein Accession: WP_122630826.1
Notes: ARO:3006167

Gene Information

Gene Name: blaGES
Allele: blaGES-39
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_062216.1
Protein Accession: WP_122630827.1
Notes: ARO:3006168

Gene Information

Gene Name: blaGES
Allele: blaGES-40
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_062356.1
Protein Accession: WP_123002100.1
Notes: ARO:3006169

Gene Information

Gene Name: blaGES
Allele: blaGES-41
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_065425.1
Protein Accession: WP_135350920.1
Notes: ARO:3006170

Gene Information

Gene Name: blaGES
Allele: blaGES-42
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_065870.1
Protein Accession: WP_148044413.1
Notes: ARO:3006171

Gene Information

Gene Name: blaGES
Allele: blaGES-43
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_065871.1
Protein Accession: WP_148044414.1
Notes: ARO:3006172

Gene Information

Gene Name: blaGES
Allele: blaGES-44
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_070735.1
Protein Accession: WP_188331868.1
Notes: ARO:3006173

Gene Information

Gene Name: blaGES
Allele: blaGES-45
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_070736.1
Protein Accession: WP_188331869.1
Notes: ARO:3006174

Gene Information

Gene Name: blaGES
Allele: blaGES-46
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_071202.1
Protein Accession: WP_197749401.1
Notes: ARO:3006175

Gene Information

Gene Name: blaGES
Allele: blaGES-66
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: JBFSES010000053.1
Protein Accession: MEX5467441.1
Notes: ARO:3008191

Gene Information

Gene Name: blaGES
Allele: blaGES-7
Encodes: GES beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Escherichia coli
Sequence Accession: AY260546.3
Protein Accession: AAP22974.1
Notes: ARO:3002336

Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae.

The study identified GES-1, a novel class A extended-spectrum beta-lactamase, which confers resistance to ceftazidime. It was cloned and expressed in E. coli, demonstrating its role in beta-lactam resistance.

Gene Information

Gene Name: blaGES
Allele: blaGES-1
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: beta-lactamase
Confers Resistance To: ceftazidime
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
Geographic Location: France|French Guiana
Validation Method: cloning in E. coli + disk diffusion
Sequence Accession: AF156486

Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae.

Gene Information

Gene Name: blaGES
Allele: blaGES-1
Encodes: extended-spectrum class A beta-lactamase GES-1
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AF156486.1
Protein Accession: AAF27723.1
Notes: Class A; perhaps some carbapenase activity

Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae.

Gene Information

Gene Name: blaGES
Allele: blaGES-1
Encodes: extended-spectrum class A beta-lactamase GES-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AF156486.1
Protein Accession: AAF27723.1
Notes: Class A; perhaps some carbapenase activity

Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae.

Gene Information

Gene Name: blaGES
Allele: blaGES-1
Encodes: extended-spectrum class A beta-lactamase GES-1, GES beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AF156486.1
Protein Accession: AAF27723.1
Notes: Class A; perhaps some carbapenase activity, ARO:3002330

IBC-1, a novel integron-associated class A beta-lactamase with extended-spectrum properties produced by an Enterobacter cloacae clinical strain.

PMID 10952563 · 2000

Gene Information

Gene Name: blaGES
Allele: blaGES-7
Encodes: extended-spectrum class A beta-lactamase GES-7
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: AF208529.2
Protein Accession: AAF28763.2
Notes: Class A; perhaps some carbapenase activity

IBC-1, a novel integron-associated class A beta-lactamase with extended-spectrum properties produced by an Enterobacter cloacae clinical strain.

PMID 10952563 · 2000

Gene Information

Gene Name: blaGES
Allele: blaGES-7
Encodes: extended-spectrum class A beta-lactamase GES-7
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: AF208529.2
Protein Accession: AAF28763.2
Notes: Class A; perhaps some carbapenase activity

IBC-1, a novel integron-associated class A beta-lactamase with extended-spectrum properties produced by an Enterobacter cloacae clinical strain.

PMID 10952563 · 2000

Gene Information

Gene Name: blaGES
Allele: blaGES-7
Encodes: extended-spectrum class A beta-lactamase GES-7
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: AF208529.2
Protein Accession: AAF28763.2
Notes: Class A; perhaps some carbapenase activity

GES-2, a class A beta-lactamase from Pseudomonas aeruginosa with increased hydrolysis of imipenem.

The study identifies GES-2, a class A beta-lactamase from Pseudomonas aeruginosa, which exhibits increased hydrolysis of imipenem compared to GES-1.

Gene Information

Gene Name: blaGES
Allele: blaGES-2
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: imipenem
Organisms Tested In: • Pseudomonas aeruginosa
• Escherichia coli
Geographic Location: South Africa
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AF326355

GES-2, a class A beta-lactamase from Pseudomonas aeruginosa with increased hydrolysis of imipenem.

Gene Information

Gene Name: blaGES
Allele: blaGES-2
Encodes: extended-spectrum class A beta-lactamase GES-2
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF326355.1
Protein Accession: AAK58421.1
Notes: Class A; perhaps some carbapenase activity

GES-2, a class A beta-lactamase from Pseudomonas aeruginosa with increased hydrolysis of imipenem.

Gene Information

Gene Name: blaGES
Allele: blaGES-2
Encodes: extended-spectrum class A beta-lactamase GES-2
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF326355.1
Protein Accession: AAK58421.1
Notes: Class A; perhaps some carbapenase activity

GES-2, a class A beta-lactamase from Pseudomonas aeruginosa with increased hydrolysis of imipenem.

Gene Information

Gene Name: blaGES
Allele: blaGES-2
Encodes: extended-spectrum class A beta-lactamase GES-2, GES beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF326355.1
Protein Accession: AAK58421.1
Notes: Class A; perhaps some carbapenase activity, ARO:3002331

GES-2, a class A beta-lactamase from Pseudomonas aeruginosa with increased hydrolysis of imipenem.

Gene Information

Gene Name: blaGES
Allele: blaGES-2
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF326355
Notes: Class A; perhaps some carbapenase activity

An integron-associated beta-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum beta-lactamase IBC-1.

Gene Information

Gene Name: blaGES
Allele: blaGES-8
Encodes: extended-spectrum class A beta-lactamase GES-8
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF329699.1
Protein Accession: AAK18183.1
Notes: Class A; perhaps some carbapenase activity

An integron-associated beta-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum beta-lactamase IBC-1.

Gene Information

Gene Name: blaGES
Allele: blaGES-8
Encodes: extended-spectrum class A beta-lactamase GES-8
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF329699.1
Protein Accession: AAK18183.1
Notes: Class A; perhaps some carbapenase activity

An integron-associated beta-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum beta-lactamase IBC-1.

Gene Information

Gene Name: blaGES
Allele: blaGES-8
Encodes: extended-spectrum class A beta-lactamase GES-8, GES beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF329699.1
Protein Accession: AAK18183.1
Notes: Class A; perhaps some carbapenase activity, ARO:3002337

An integron-associated beta-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum beta-lactamase IBC-1.

Gene Information

Gene Name: blaGES
Allele: blaGES-8
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF329699
Notes: Class A; perhaps some carbapenase activity

Molecular characterization of a new class 3 integron in Klebsiella pneumoniae.

PMID 12936982 · 2003

The study identifies a new class 3 integron in Klebsiella pneumoniae FFUL 22K carrying the blaGES-1 gene cassette, which confers resistance to extended-spectrum cephalosporins.

Gene Information

Gene Name: blaGES
Allele: blaGES-1
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: extended-spectrum beta-lactamase
Confers Resistance To: cephalosporins
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
Geographic Location: Portugal
Validation Method: cloning and MIC testing
Sequence Accession: AY219651

Novel GES/IBC extended-spectrum beta-lactamase variants with carbapenemase activity in clinical enterobacteria.

Gene Information

Gene Name: blaGES
Allele: blaGES-5
Encodes: carbapenem-hydrolyzing class A beta-lactamase GES-5
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Escherichia coli
Sequence Accession: AY494717.1
Protein Accession: AAR97270.1
Notes: Class A; perhaps some carbapenase activity

Novel GES/IBC extended-spectrum beta-lactamase variants with carbapenemase activity in clinical enterobacteria.

Gene Information

Gene Name: blaGES
Allele: blaGES-5
Encodes: carbapenem-hydrolyzing class A beta-lactamase GES-5
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Escherichia coli
Sequence Accession: AY494717.1
Protein Accession: AAR97270.1
Notes: Class A; perhaps some carbapenase activity

Novel GES/IBC extended-spectrum beta-lactamase variants with carbapenemase activity in clinical enterobacteria.

Gene Information

Gene Name: blaGES
Allele: blaGES-5
Encodes: carbapenem-hydrolyzing class A beta-lactamase GES-5, GES beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Escherichia coli
Sequence Accession: AY494717.1
Protein Accession: AAR97270.1
Notes: Class A; perhaps some carbapenase activity, ARO:3002334

Novel GES/IBC extended-spectrum beta-lactamase variants with carbapenemase activity in clinical enterobacteria.

Gene Information

Gene Name: blaGES
Allele: blaGES-6
Encodes: inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase GES-6
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AY494718.1
Protein Accession: AAR97271.1
Notes: Class A; perhaps some carbapenase activity

Novel GES/IBC extended-spectrum beta-lactamase variants with carbapenemase activity in clinical enterobacteria.

Gene Information

Gene Name: blaGES
Allele: blaGES-6
Encodes: inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase GES-6
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AY494718.1
Protein Accession: AAR97271.1
Notes: Class A; perhaps some carbapenase activity

Novel GES/IBC extended-spectrum beta-lactamase variants with carbapenemase activity in clinical enterobacteria.

Gene Information

Gene Name: blaGES
Allele: blaGES-6
Encodes: inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase GES-6, GES beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AY494718.1
Protein Accession: AAR97271.1
Notes: Class A; perhaps some carbapenase activity, ARO:3002335

Novel GES/IBC extended-spectrum beta-lactamase variants with carbapenemase activity in clinical enterobacteria.

Gene Information

Gene Name: blaGES
Allele: blaGES-6
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AY494718
Notes: Class A; perhaps some carbapenase activity

Nosocomial spread of ceftazidime-resistant Klebsiella pneumoniae strains producing a novel class a beta-lactamase, GES-3, in a neonatal intensive care unit in Japan.

The study identifies a novel class A beta-lactamase, GES-3, which confers resistance to ceftazidime in ceftazidime-resistant Klebsiella pneumoniae strains isolated from a neonatal intensive care unit in Japan.

Gene Information

Gene Name: blaGES
Allele: blaGES-3
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of beta-lactam antibiotics
Confers Resistance To: ceftazidime
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
Geographic Location: Japan
Validation Method: cloning and sequence analysis
Sequence Accession: AB113580

Nosocomial spread of ceftazidime-resistant Klebsiella pneumoniae strains producing a novel class a beta-lactamase, GES-3, in a neonatal intensive care unit in Japan.

Gene Information

Gene Name: blaGES
Allele: blaGES-3
Encodes: extended-spectrum class A beta-lactamase GES-3
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AB113580.1
Protein Accession: BAD06399.1
Notes: Class A; perhaps some carbapenase activity

Nosocomial spread of ceftazidime-resistant Klebsiella pneumoniae strains producing a novel class a beta-lactamase, GES-3, in a neonatal intensive care unit in Japan.

Gene Information

Gene Name: blaGES
Allele: blaGES-3
Encodes: extended-spectrum class A beta-lactamase GES-3
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AB113580.1
Protein Accession: BAD06399.1
Notes: Class A; perhaps some carbapenase activity

Nosocomial spread of ceftazidime-resistant Klebsiella pneumoniae strains producing a novel class a beta-lactamase, GES-3, in a neonatal intensive care unit in Japan.

Gene Information

Gene Name: blaGES
Allele: blaGES-3
Encodes: extended-spectrum class A beta-lactamase GES-3, GES beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AB113580.1
Protein Accession: BAD06399.1
Notes: Class A; perhaps some carbapenase activity, ARO:3002332

Nosocomial spread of ceftazidime-resistant Klebsiella pneumoniae strains producing a novel class a beta-lactamase, GES-3, in a neonatal intensive care unit in Japan.

Gene Information

Gene Name: blaGES
Allele: blaGES-3
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AB113580
Notes: Class A; perhaps some carbapenase activity

Molecular characterization of a cephamycin-hydrolyzing and inhibitor-resistant class A beta-lactamase, GES-4, possessing a single G170S substitution in the omega-loop.

The study identifies GES-4, a class A beta-lactamase with a G170S substitution in the omega-loop, which confers resistance to cephamycins and carbapenems and exhibits inhibitor resistance.

Gene Information

Gene Name: blaGES
Allele: blaGES-4
Encodes: class A beta-lactamase
Source Database: Reslit
Confers Resistance To: cefoxitinimipenemmeropenem
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
Geographic Location: Japan
Validation Method: cloning and sequencing analysis
Sequence Accession: AB116260|AB116723

Molecular characterization of a cephamycin-hydrolyzing and inhibitor-resistant class A beta-lactamase, GES-4, possessing a single G170S substitution in the omega-loop.

Gene Information

Gene Name: blaGES
Allele: blaGES-4
Encodes: inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase GES-4
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AB116260.1
Protein Accession: BAD08689.1
Notes: Class A; perhaps some carbapenase activity

Molecular characterization of a cephamycin-hydrolyzing and inhibitor-resistant class A beta-lactamase, GES-4, possessing a single G170S substitution in the omega-loop.

Gene Information

Gene Name: blaGES
Allele: blaGES-4
Encodes: inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase GES-4
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AB116260.1
Protein Accession: BAD08689.1
Notes: Class A; perhaps some carbapenase activity

Molecular characterization of a cephamycin-hydrolyzing and inhibitor-resistant class A beta-lactamase, GES-4, possessing a single G170S substitution in the omega-loop.

Gene Information

Gene Name: blaGES
Allele: blaGES-4
Encodes: inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase GES-4, GES beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AB116260.1
Protein Accession: BAD08689.1
Notes: Class A; perhaps some carbapenase activity, ARO:3002333

Molecular characterization of a cephamycin-hydrolyzing and inhibitor-resistant class A beta-lactamase, GES-4, possessing a single G170S substitution in the omega-loop.

Gene Information

Gene Name: blaGES
Allele: blaGES-4
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AB116723
Notes: Class A; perhaps some carbapenase activity

Integron-encoded GES-type extended-spectrum beta-lactamase with increased activity toward aztreonam in Pseudomonas aeruginosa.

The study identifies a novel GES-type extended-spectrum beta-lactamase, GES-9, which exhibits increased activity towards aztreonam in Pseudomonas aeruginosa. The gene is located in a class 1 integron and shows resistance to several beta-lactam antibiotics.

Gene Information

Gene Name: blaGES
Allele: blaGES-9
Encodes: extended-spectrum beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: aztreonam
Organisms Tested In: • Pseudomonas aeruginosa
• Escherichia coli
Geographic Location: France
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AY920928

Integron-encoded GES-type extended-spectrum beta-lactamase with increased activity toward aztreonam in Pseudomonas aeruginosa.

Gene Information

Gene Name: blaGES
Allele: blaGES-9
Encodes: extended-spectrum class A beta-lactamase GES-9
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: AZTREONAMTICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY920928.1
Protein Accession: AAY43207.1
Notes: Class A; perhaps some carbapenase activity

100

Integron-encoded GES-type extended-spectrum beta-lactamase with increased activity toward aztreonam in Pseudomonas aeruginosa.

Gene Information

Gene Name: blaGES
Allele: blaGES-9
Encodes: extended-spectrum class A beta-lactamase GES-9
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AZTREONAMTICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY920928.1
Protein Accession: AAY43207.1
Notes: Class A; perhaps some carbapenase activity

101

Integron-encoded GES-type extended-spectrum beta-lactamase with increased activity toward aztreonam in Pseudomonas aeruginosa.

Gene Information

Gene Name: blaGES
Allele: blaGES-9
Encodes: extended-spectrum class A beta-lactamase GES-9, GES beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: AZTREONAMTICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY920928.1
Protein Accession: AAY43207.1
Notes: Class A; perhaps some carbapenase activity, ARO:3002338

102

Integron-encoded GES-type extended-spectrum beta-lactamase with increased activity toward aztreonam in Pseudomonas aeruginosa.

Gene Information

Gene Name: blaGES
Allele: blaGES-9
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AZTREONAMTICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY920928
Notes: Class A; perhaps some carbapenase activity

103

Emergence of blaGES-5 in clinical colistin-only-sensitive (COS) Pseudomonas aeruginosa strain in Brazil.

PMID 17284538 · 2007

Gene Information

Gene Name: blaGES
Allele: blaGES-5
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: DQ236171
Notes: Class A; perhaps some carbapenase activity

104

BlasGES carrying Pseudomonas aeruginosa isolates from a public hospital in Rio de Janeiro, Brazil.

PMID 17293906 · 2006

The study identified the blaGES gene in Pseudomonas aeruginosa isolates from a public hospital in Rio de Janeiro, Brazil, which confers resistance to multiple beta-lactam antibiotics including ceftazidime, cefepime, imipenem, meropenem, piperacillin-tazobactam, and ticarcillin-clavulanic acid.

Gene Information

Gene Name: blaGES
Allele: blaGES
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: ceftazidimecefepimeimipenemmeropenempiperacillin tazobactamticarcillin clavulanic acid
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Rio de Janeiro|Brazil
Validation Method: PCR and phenotypic synergy test

105

Integron mobilization unit as a source of mobility of antibiotic resistance genes.

PMID 19332679 · 2009

The study identifies the blaGES-5 gene, a carbapenemase, located on a novel genetic structure called the integron mobilization unit (IMU), which facilitates the mobilization of antibiotic resistance genes.

Gene Information

Gene Name: blaGES
Allele: blaGES-5
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacter cloacae
• Escherichia coli
• Pseudomonas aeruginosa
Validation Method: cloning and MIC testing
Sequence Accession: EU266532

106

GES-11, a novel integron-associated GES variant in Acinetobacter baumannii.

The study identifies GES-11, a novel integron-associated GES variant in Acinetobacter baumannii, which confers resistance to beta-lactams, including aztreonam, and reduces susceptibility to carbapenems.

Gene Information

Gene Name: blaGES
Allele: blaGES-11
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: aztreonamcarbapenems
Organisms Tested In: • Acinetobacter baumannii
• Escherichia coli
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: FJ854362

107

GES-11, a novel integron-associated GES variant in Acinetobacter baumannii.

Gene Information

Gene Name: blaGES
Allele: blaGES-11
Encodes: extended-spectrum class A beta-lactamase GES-11
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Acinetobacter baumannii
Sequence Accession: FJ854362.1
Protein Accession: ACS44714.1
Notes: Class A; perhaps some carbapenase activity

108

GES-11, a novel integron-associated GES variant in Acinetobacter baumannii.

Gene Information

Gene Name: blaGES
Allele: blaGES-11
Encodes: extended-spectrum class A beta-lactamase GES-11
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Acinetobacter baumannii
Sequence Accession: FJ854362.1
Protein Accession: ACS44714.1
Notes: Class A; perhaps some carbapenase activity

109

GES-11, a novel integron-associated GES variant in Acinetobacter baumannii.

Gene Information

Gene Name: blaGES
Allele: blaGES-11
Encodes: extended-spectrum class A beta-lactamase GES-11, GES beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Acinetobacter baumannii
Sequence Accession: FJ854362.1
Protein Accession: ACS44714.1
Notes: Class A; perhaps some carbapenase activity, ARO:3002340

110

GES-11, a novel integron-associated GES variant in Acinetobacter baumannii.

Gene Information

Gene Name: blaGES
Allele: blaGES-11
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Acinetobacter baumannii
Sequence Accession: FJ854362
Notes: Class A; perhaps some carbapenase activity

111

Evidence for dynamic exchange of qac gene cassettes between class 1 integrons and other integrons in freshwater biofilms.

Gene Information

Gene Name: blaGES
Allele: blaGES-10
Encodes: extended-spectrum class A beta-lactamase GES-10
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • uncultured bacterium
Sequence Accession: FJ820124.1
Protein Accession: ACS73598.1
Notes: Class A; perhaps some carbapenase activity

112

Evidence for dynamic exchange of qac gene cassettes between class 1 integrons and other integrons in freshwater biofilms.

Gene Information

Gene Name: blaGES
Allele: blaGES-10
Encodes: extended-spectrum class A beta-lactamase GES-10
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • uncultured bacterium
Sequence Accession: FJ820124.1
Protein Accession: ACS73598.1
Notes: Class A; perhaps some carbapenase activity

113

Evidence for dynamic exchange of qac gene cassettes between class 1 integrons and other integrons in freshwater biofilms.

Gene Information

Gene Name: blaGES
Allele: blaGES-10
Encodes: extended-spectrum class A beta-lactamase GES-10, GES beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • uncultured bacterium
Sequence Accession: FJ820124.1
Protein Accession: ACS73598.1
Notes: Class A; perhaps some carbapenase activity, ARO:3002339

114

Evidence for dynamic exchange of qac gene cassettes between class 1 integrons and other integrons in freshwater biofilms.