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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
carbapenem-hydrolyzing class A beta-lactamase IMI-10
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaIMI-10 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Enterobacter asburiae | - | - | JAXAFB010000014.1 | MDX7665057.1 |
| blaIMI-12 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Enterobacter cloacae | - | - | KX231872.1 | ANE37624.1 |
| blaIMI-13 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Enterobacter asburiae | - | - | KX371620.1 | ANJ78207.1 |
| blaIMI-14 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Enterobacter hormaechei | - | - | KY501227.1 | APY16311.1 |
| blaIMI-15 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Enterobacter cloacae subsp. cloacae | - | - | KY688372.1 | AQW35407.1 |
| blaIMI-16 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Enterobacter cloacae | - | - | MF373390.1 | ASE05857.1 |
| blaIMI-17 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Enterobacter cloacae | - | - | MG450750.1 | ATU32976.1 |
| blaIMI-18 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Enterobacter cloacae | - | - | LC439298.1 | BBH72281.1 |
| blaIMI-19 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Enterobacter cloacae | - | - | MK807025.1 | QCE31565.1 |
| blaIMI-20 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Enterobacter bugandensis | - | - | MN619794.1 | QFX75996.1 |
| blaIMI-21 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Enterobacter asburiae | - | - | MW349708.1 | QPQ08641.1 |
| blaIMI-24 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Enterobacter asburiae | - | - | OM525830.1 | ULG04426.1 |
| blaIMI-25 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Enterobacter cloacae complex sp. | - | - | PP296989.1 | WVW91583.1 |
| blaIMI-26 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Enterobacter cloacae complex sp. | - | - | PP296990.1 | WVW91584.1 |
| blaIMI-27 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Enterobacter cloacae complex sp. | - | - | PP296988.1 | WVW91582.1 |
| blaIMI-29 | Reference Gene Catalog | 1 | CARBAPENEM | Enterobacter cloacae | - | - | PQ666869.1 | XMD53574.1 |
| blaIMI-30 | Reference Gene Catalog | 1 | CARBAPENEM | Enterobacter asburiae | - | - | PV010178.1 | XNY97132.1 |
| blaIMI-31 | Reference Gene Catalog | 1 | CARBAPENEM | Enterobacter asburiae | - | - | PX101847.1 | XYS97104.1 |
| blaIMI-4 | Card DatabaseReference Gene CatalogResFinder Database | 4 | MEROPENEM, ERTAPENEM +13 | Enterobacter cloacae | - | - | KF958750.1 | AHE78014.1 |
| blaIMI-7 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Enterobacter cloacae | - | - | KM103296.1 | AIS19858.1 |
| blaIMI-8 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Enterobacter cloacae | - | - | KP081315.1 | AIY69088.1 |
| blaIMI-5 | Card DatabaseReference Gene CatalogResFinder Database | 5 | MEROPENEM, ERTAPENEM +13 | Enterobacter cloacae | - | 2017 | NG_054695.1 | WP_085562405.1 |
| blaIMI-6 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Klebsiella ornithinolytica | - | 2017 | NG_049168.1 | WP_063860570.1 |
| blaIMI-9 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Enterobacter sp. 50588862 | - | 2017 | NG_049171.1 | WP_060571602.1 |
| blaNMC-A | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 10 | imipenem, meropenem +7 | Enterobacter cloacae +4 | North America, Greece, Atlanta | 1994, 2003, 2012, 2021, 2022, 2025 | NC_006335 | CAA79967.1 |
| bla_IMI-2 | Reslit | 4 | carbapenems, penicillin +3 | Enterobacter asburiae +2 | Midwest|United States, Los Angeles|Southern California, Israel, Sweden | 2005, 2019, 2020, 2022 | NCBI:AF345915 | - |
| blaIMI-2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | MEROPENEM, ERTAPENEM +16 | Enterobacter asburiae +6 | Europe, Los Angeles|Southern California, India, Asia|Latin America and the Caribbean, Tunisia | 2005, 2017, 2019, 2022, 2023 | DQ173429.1 | ABA00479.1 |
| blaIMI-3 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | MEROPENEM, ERTAPENEM +14 | Enterobacter cloacae | France | 2011, 2016 | GU015024.1 | ACX71212.1 |
| bla<IMI>-1 | Reslit | 1 | carbapenems | Enterobacter cloacae | China | 2015 | KP284436 | - |
| blaIMI | Reslit | 8 | carbapenems, meropenem +2 | Enterobacteriaceae +8 | Norway, Philippines, Europe, France, Shanxi Province|Shanxi Province, China, United States|China|Colombia|Argentina|Chile|Australia|Singapore, Peru | 2017, 2020, 2021, 2022, 2023, 2025 | PRJNA295003 | - |
| IMI | Reslit | 2 | carbenicillin, ertapenem +1 | Vibrio cholerae | Connecticut, South Africa|various water sources | 2019, 2020 | MN046275|MN046276|MN046277|MN046278|MN046279|MN046280|MN046281|MN046282|MN046283|MN046284|MN046285|MN046286|MN046287|MN046288|MN046289|MN046290|MN046291|MN046292|MN046293|MN046294|MN046295|MN046296|MN046297|MN046298|MN046299|MN046300|MN046301|MN046918|MN046919|MN046920|MN046921|MN046922|MN046923|MN046924|MN046925|MN046926|MN046927 | - |
| NMC-A | Reslit | 1 | carbenicillin | - | Connecticut | 2019 | MN046275|MN046276|MN046277|MN046278|MN046279|MN046280|MN046281|MN046282|MN046283|MN046284|MN046285|MN046286|MN046287|MN046288|MN046289|MN046290|MN046291|MN046292|MN046293|MN046294|MN046295|MN046296|MN046297|MN046298|MN046299|MN046300|MN046301|MN046918|MN046919|MN046920|MN046921|MN046922|MN046923|MN046924|MN046925|MN046926|MN046927 | - |
| bla_IMI-20 | Reslit | 1 | carbapenems | Enterobacter bugandensis | Israel | 2020 | MN619794 | - |
| blaIMI-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | carbapenems, imipenem relebactam +16 | Enterobacter bugandensis +3 | United States, Switzerland, International Space Station, Comoros|Madagascar|Maldives|Mauritius|Mayotte|Reunion Island|Seychelles|Sri Lanka|Zanzibar, Europe|Pakistan | 1996, 2020, 2023, 2024, 2025 | MT215236|MT215237|MT215238|MT215239 | AAA93461.1 |
| bla_IMI | Reslit | 1 | carbapenems | Enterobacter cloacae | Singapore | 2021 | pNDM-ECS01|pHS102707 | - |
| bla_IMI-1 | Reslit | 1 | imipenem | Enterobacter bugandensis S68-1 | central Arkansas (USA) | 2021 | PRJNA705736 | - |
| bla_IMI-17 | Reslit | 1 | meropenem, ertapenem +2 | Enterobacter ludwigii | Israel | 2021 | - | - |
| blaIMI-22 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Serratia ureilytica | - | 2022 | CP074169.1 | UAN29788.1 |
| blaIMI-23 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Serratia ureilytica | - | 2022 | CP074169.1 | UAN29726.1 |
| bla(IMI-6) | Reslit | 1 | carbapenems | Enterobacter ludwigii +1 | Spain | 2023 | JAPHQK000000000 | - |
| bla(IMI-4) | Reslit | 1 | carbapenems | Enterobacter roggenkampii +1 | Costa Rica | 2025 | SAMN43046597|SAMN43046598 | - |
NmcA carbapenem-hydrolyzing enzyme in Enterobacter cloacae in North America.
The study reports the identification of the NmcA carbapenem-hydrolyzing enzyme in an imipenem-resistant Enterobacter cloacae isolate from North America, confirming its ability to hydrolyze carbapenems and its inducibility by β-lactam antibiotics.
Carbapenemase-producing Enterobacteriaceae, U.S. rivers.
The study identifies a novel plasmid-encoded carbapenemase, IMI-2, in Enterobacter asburiae isolates from U.S. rivers, which confers resistance to carbapenems, penicillins, and aztreonam.
Carbapenemase-producing Enterobacteriaceae, U.S. rivers.
Carbapenemase-producing Enterobacteriaceae, U.S. rivers.
Carbapenemase-producing Enterobacteriaceae, U.S. rivers.
Carbapenemase-producing Enterobacteriaceae, U.S. rivers.
Carbapenemases in enterobacteria, Hong Kong, China, 2009.
Carbapenemases in enterobacteria, Hong Kong, China, 2009.
Carbapenemases in enterobacteria, Hong Kong, China, 2009.
Activity of ceftaroline-avibactam tested against Gram-negative organism populations, including strains expressing one or more β-lactamases and methicillin-resistant Staphylococcus aureus carrying various staphylococcal cassette chromosome mec types.
Ceftaroline-avibactam showed potent activity against β-lactamase-producing Enterobacteriaceae, including those with multiple β-lactamases, and was effective against KPC-producing strains. It had limited activity against Acinetobacter spp. and P. aeruginosa.
Molecular Characterization of Carbapenem-Nonsusceptible Enterobacterial Isolates Collected during a Prospective Interregional Survey in France and Susceptibility to the Novel Ceftazidime-Avibactam and Aztreonam-Avibactam Combinations.
The study identified two carbapenemase-producing isolates, one producing OXA-48 and another producing IMI-3, which conferred resistance to carbapenems. Additionally, porin deficiencies in conjunction with AmpC and/or ESBLs were widespread among the CNSE isolates.
First identification of an IMI-1 carbapenemase-producing colistin-resistant Enterobacter cloacae in China.
The study reports the first identification of an IMI-1 carbapenemase-producing colistin-resistant Enterobacter cloacae strain in China, highlighting the emergence of multidrug-resistant Enterobacteriaceae and the need for increased surveillance of colistin resistance.
Comparison of 11 Phenotypic Assays for Accurate Detection of Carbapenemase-Producing Enterobacteriaceae
The study evaluates 11 phenotypic assays for the detection of carbapenemase-producing Enterobacteriaceae (CPE) and identifies the effectiveness of various assays in detecting different types of carbapenemase genes, including bla KPC, bla NDM, bla OXA-48-type, bla VIM, bla IMP, bla SME, and bla IMI.
Enterobacter cloacae Complex Isolates Harboring bla(NMC-A) or bla(IMI)-Type Class A Carbapenemase Genes on Novel Chromosomal Integrative Elements and Plasmids.
Enterobacter cloacae Complex Isolates Harboring bla(NMC-A) or bla(IMI)-Type Class A Carbapenemase Genes on Novel Chromosomal Integrative Elements and Plasmids.
Enterobacter cloacae Complex Isolates Harboring bla(NMC-A) or bla(IMI)-Type Class A Carbapenemase Genes on Novel Chromosomal Integrative Elements and Plasmids.
Enterobacter cloacae Complex Isolates Harboring bla(NMC-A) or bla(IMI)-Type Class A Carbapenemase Genes on Novel Chromosomal Integrative Elements and Plasmids.
Enterobacter cloacae Complex Isolates Harboring bla(NMC-A) or bla(IMI)-Type Class A Carbapenemase Genes on Novel Chromosomal Integrative Elements and Plasmids.
Enterobacter cloacae Complex Isolates Harboring bla(NMC-A) or bla(IMI)-Type Class A Carbapenemase Genes on Novel Chromosomal Integrative Elements and Plasmids.
Carbapenemase-producing enterobacteriaceae recovered from a Spanish river ecosystem.
The study identified carbapenemase-producing Enterobacteriaceae (CPE) in a river ecosystem, including KPC-2, VIM-1, and IMI-2 carbapenemases. These enzymes were found in various species such as Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, Klebsiella oxytoca, and Raoultella ornithinolytica.
Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014.
The study identified various carbapenemase genes including bla KPC, bla NDM, bla OXA-48-like, bla VIM, bla IMI, and bla IMP in different Enterobacteriaceae species. These genes conferred resistance to carbapenems. Additionally, mutations in pmrA and pmrB were associated with colistin resistance in Klebsiella pneumoniae.
Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014.
Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014.
Prevalence and characterization of carbapenem-resistant bacteria in water bodies in the Los Angeles-Southern California area.
The study identified bla_IMI-2 and bla_L1 as carbapenemase genes in carbapenem-resistant bacteria from water bodies in the Los Angeles area, highlighting the presence of these resistance mechanisms in environmental samples.
Prevalence and characterization of carbapenem-resistant bacteria in water bodies in the Los Angeles-Southern California area.
The study identified bla_IMI-2 and bla_L1 as carbapenemase genes in carbapenem-resistant bacteria from water bodies in the Los Angeles area, highlighting the presence of these resistance mechanisms in environmental samples.
Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products.
The study identifies two novel carbapenemases, FLC-1 and IMI-2, encoded by an Enterobacter cloacae complex isolate from imported seafood. Both enzymes belong to Ambler class A beta-lactamases and confer resistance to carbapenems.
Antibiotic resistant bacteria and commensal fungi are common and conserved in the mosquito microbiome.
The study identifies several antibiotic resistance genes in the microbiome of colony-reared and field-caught mosquitoes, highlighting the presence of antibiotic resistant bacteria and fungi in the mosquito microbiome.
Antibiotic resistant bacteria and commensal fungi are common and conserved in the mosquito microbiome.
The study identifies several antibiotic resistance genes in the microbiome of colony-reared and field-caught mosquitoes, highlighting the presence of antibiotic resistant bacteria and fungi in the mosquito microbiome.
Environmental Presence and Genetic Characteristics of Carbapenemase-Producing Enterobacteriaceae from Hospital Sewage and River Water in the Philippines.
The study identified NDM, KPC, OXA-48-like, GES, and IMI carbapenemase genes in carbapenemase-producing Enterobacteriaceae (CPE) isolated from hospital sewage and river water in the Philippines. NDM was the most prevalent gene type, followed by KPC, OXA-48-like, GES, and IMI. Additionally, CTX-M-type ESBL and 16S rRNA methylase genes were also detected.
Antibiotic Susceptibility Testing (AST) Reports: A Basis for Environmental/Epidemiological Surveillance and Infection Control Amongst Environmental Vibrio cholerae.
The study identified various antibiotic resistance genes in Vibrio cholerae isolates, including blaTEM, NDM-1, AmpC, and ESBL, indicating multidrug resistance in environmental V. cholerae.
Multidrug-resistant enterobacteriaceae in coastal water: an emerging threat.
The study identifies two novel beta-lactamase genes, bla_IMI-2 and bla_IMI-20, which confer resistance to carbapenems in Enterobacter species isolated from coastal and riverine water samples.
Multidrug-resistant enterobacteriaceae in coastal water: an emerging threat.
The study identifies two novel beta-lactamase genes, bla_IMI-2 and bla_IMI-20, which confer resistance to carbapenems in Enterobacter species isolated from coastal and riverine water samples.
Carbapenemase-Producing Gram-Negative Bacteria from American Crows in the United States.
The study identified carbapenemase-producing Gram-negative bacteria in American crows, including Providencia rettgeri with blaIMP-27, Klebsiella pneumoniae with blaKPC-2, and Enterobacter bugandensis with blaIMI-1.
Epidemiology and Transmission of Carbapenemase-Producing Enterobacteriaceae in a Health Care Network of an Acute-Care Hospital and Its Affiliated Intermediate- and Long-Term-Care Facilities in Singapore.
The study identified several carbapenemase genes, including bla_IMI, bla_NDM-1, and bla_KPC-2, in Enterobacteriaceae isolates from an acute-care hospital and its affiliated intermediate- and long-term-care facilities in Singapore. These genes were associated with carbapenem resistance and were found in various bacterial species such as Enterobacter cloacae and Escherichia coli.
Detection of carbapenemase producing enterobacteria using an ion sensitive field effect transistor sensor.
The study evaluated the effectiveness of an ion-sensitive field-effect transistor (ISFET) sensor for detecting carbapenemase-producing enterobacteria. It successfully identified various carbapenemase genes including blaNDM-1, blaVIM-1, blaIMP-1, blaKPC-2, blaNMC-A, and blaOXA-48 in different bacterial strains.
One-Step Detection and Classification of Bacterial Carbapenemases in 10 Minutes Using Fluorescence Identification of β-Lactamase Activity.
The study presents a novel assay called FIBA for the rapid detection and classification of bacterial carbapenemases. It identifies various carbapenemase types including KPC, SME, NMC-A, NDM, VIM, IMP, and OXA, demonstrating high sensitivity and specificity.
Isolation and characterisation of carbapenemase-producing and polymyxin B-resistant Enterobacter bugandensis from a vegetable.
Carbapenem-resistant Enterobacter bugandensis S68-1 was isolated from a vegetable and was found to possess the bla_IMI-1 gene, which encodes a serine carbapenemase responsible for imipenem resistance.
Multiplex lateral flow immunochromatographic assay is an effective method to detect carbapenemases without risk of OXA-48-like cross reactivity.
The study evaluates the NG-Test® CARBA 5 assay for detecting carbapenemases in Enterobacterales, showing high sensitivity and specificity. It identifies bla KPC, bla OXA-48-like, bla NDM, bla VIM, bla IMP, bla IMI, and bla SME as the main carbapenemase genes detected.
A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital.
The study identifies bla_IMI-17 as a carbapenemase gene responsible for resistance in Enterobacter ludwigii during an outbreak.
Emergence of rare carbapenemases (FRI, GES-5, IMI, SFC and SFH-1) in Enterobacterales isolated from surface waters in Japan.
Emergence of rare carbapenemases (FRI, GES-5, IMI, SFC and SFH-1) in Enterobacterales isolated from surface waters in Japan.
Emergence of rare carbapenemases (FRI, GES-5, IMI, SFC and SFH-1) in Enterobacterales isolated from surface waters in Japan.
Emergence of rare carbapenemases (FRI, GES-5, IMI, SFC and SFH-1) in Enterobacterales isolated from surface waters in Japan.
Prevalence of Antimicrobial Resistance in Select Bacteria From Retail Seafood-United States, 2019.
The study identified carbapenemases (bla IMI-2, bla NDM-1) and extended spectrum beta-lactamase (bla CTX-M-55) in seafood isolates, indicating the presence of antimicrobial resistance genes in retail seafood.
Direct Colorimetry of Imipenem Decomposition as a Novel Cost-Effective Method for Detecting Carbapenemase-Producing Enterobacteria.
The study presents a novel, cost-effective method for detecting carbapenemase-producing enterobacteria (CPE) using direct colorimetry of imipenem decomposition. The method relies on the specific color change induced by carbapenemases, particularly NDM-1, NMC-A, OXA-48, VIM-1, IMP-4, and KPC-2, which were experimentally validated for their ability to hydrolyze imipenem and produce a measurable yellow color. The method demonstrated high sensitivity (98%) and specificity (100%).
Evaluation of the EasyScreen™ ESBL/CPO Detection Kit for the Detection of ß-Lactam Resistance Genes.
The EasyScreen™ ESBL/CPO Detection Kit effectively detects various β-lactam resistance genes, including bla VIM, bla NDM, bla IMP, bla OXA-48, bla KPC, bla OXA-23, bla OXA-51, bla SME, bla IMI, bla GES, bla TEM, bla SHV, bla CTX-M, bla CMY, bla DHA, and the mcr-1 gene, demonstrating high sensitivity and specificity for carbapenemase and ESBL detection in Enterobacterales, Pseudomonas spp., and Acinetobacter spp.
Detection of an IMI-2 carbapenemase-producing Enterobacter asburiae at a Swedish feed mill.
The study identified a carbapenemase-producing Enterobacter asburiae isolate carrying the bla IMI-2 gene on a plasmid, highlighting the presence of carbapenem resistance in feed mill environments.
First Report of IMI-2-Producing Enterobacter bugandensis and CTX-M-55-Producing Escherichia coli isolated from Healthy Volunteers in Tunisia.
The study reports the first detection of IMI-2-producing Enterobacter bugandensis and CTX-M-55-producing Escherichia coli in healthy volunteers in Tunisia, highlighting the presence of extended-spectrum beta-lactamases and carbapenemases in the fecal microbiota of healthy individuals.
Impact of Minor Carbapenemases on Susceptibility to Novel β-Lactam/β-Lactamase Inhibitor Combinations and Cefiderocol in Enterobacterales.
The study characterizes the impact of minor carbapenemases (SME-1, NmcA, IMI-1, and FRI-1) on susceptibility to imipenem-relebactam, meropenem-vaborbactam, and cefiderocol in Enterobacterales. It shows that these carbapenemases significantly reduce susceptibility to imipenem-relebactam but not to meropenem-vaborbactam or cefiderocol.
Phenotypic and Molecular Characterization of an Enterobacter ludwigii Clinical Isolate Carrying a Plasmid-Mediated bla(IMI-6) Gene.
The study identifies a plasmid-mediated bla(IMI-6) gene in an Enterobacter ludwigii isolate from Spain, which confers resistance to carbapenems. The gene was transferred to E. coli J53, confirming its role in carbapenem resistance.
Molecular Epidemiology of Carbapenem Resistant Klebsiella Pneumoniae in Northern China: Clinical Characteristics, Antimicrobial Resistance, Virulence and Geographic Distribution.
The study identified several carbapenemase genes, including bla NDM-1, bla NDM-5, bla KPC-2, bla OXA-23, bla SME, and bla IMI, as well as extended-spectrum beta-lactamase genes such as bla CTX-M, bla SHV, and bla TEM, and AmpC beta-lactamase gene bla DHA, which contribute to carbapenem resistance in CRKP isolates from Shanxi Province.
Genomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space Station.
The study identifies multiple antibiotic resistance genes in multidrug-resistant Enterobacter bugandensis strains isolated from the International Space Station, highlighting their potential to persist and succeed in extreme environments.
Comprehensive analysis of antimicrobial resistance in the Southwest Indian Ocean: focus on WHO critical and high priority pathogens.
The study identifies multiple carbapenem-resistant Enterobacterales, Acinetobacter spp., Pseudomonas spp., and vancomycin-resistant Enterococcus spp. with various resistance genes such as bla NDM-1, bla NDM-4, bla NDM-5, bla NDM-6, bla OXA-181, bla IMI-1, bla OXA-23, bla OXA-24, bla OXA-58, bla VIM-2, and vanA.
Molecular Epidemiology and Clinical Characterization of Carbapenemase-Producing Enterobacter Species From an International Cohort.
The study identifies bla KPC, bla NDM, bla IMP, bla IMI, and bla VIM as the primary carbapenemase genes in carbapenemase-producing Enterobacter species, along with fluoroquinolone resistance mutations in gyrA and parC, and porin gene mutations in ompF and ompC.
First identification and whole-genome characterization of human-associated Enterobacter roggenkampii and Enterobacter sichuanensis carrying bla(IMI-4) carbapenemase in Costa Rica.
The study identifies the first occurrence of bla(IMI-4) carbapenemase in Costa Rica, carried by Enterobacter roggenkampii and Enterobacter sichuanensis. The gene is located within a chromosomal EcloIMEX-2-like element, highlighting its potential for interspecies mobility.
Evaluation of expert rules for carbapenemase class identification in Enterobacterales isolates using the VITEK2 susceptibility testing platform.
The study evaluated the performance of bioMérieux Advanced Reporting Tool (bioART) expert rules for identifying carbapenemase classes in Enterobacterales isolates using the VITEK2 platform. It found that the bioART rules, when combined with the VITEK2 Advanced Expert System (AES), improved the detection of carbapenemase-producing isolates, particularly for KPC, MBL, and OXA-48-like enzymes.
In vitro activity of cefiderocol against nosocomial Acinetobacter baumannii.
The study assessed the in vitro activity of cefiderocol against multidrug-resistant Acinetobacter baumannii isolates and found that cefiderocol exhibited high efficacy, with very low resistance rates. However, the presence of various beta-lactamase genes, including bla OXA-23G, bla OXA-24G, bla OXA-48G, bla OXA-58G, bla VEB, bla PER, bla GES, bla KPC, bla NDM, bla VIM, bla IMP, and bla IMI, was associated with resistance to other antibiotics.
No evidence of multidrug-resistant Enterobacterales transmission between healthy companion animals and pet owners in the greater Atlanta area: a pilot study.
The study identified several AMR genes and mutations in E. coli isolates from both humans and pets, including blaCMY-2, blaCTX-M-15, blaTEM-1B, and mutations in gyrA and parC. These findings highlight the presence of multidrug-resistant Enterobacterales in healthy individuals and their companion animals.
Analysis of a carbapenem-hydrolyzing class A beta-lactamase from Enterobacter cloacae and of its LysR-type regulatory protein.
Analysis of a carbapenem-hydrolyzing class A beta-lactamase from Enterobacter cloacae and of its LysR-type regulatory protein.
Analysis of a carbapenem-hydrolyzing class A beta-lactamase from Enterobacter cloacae and of its LysR-type regulatory protein.
Characterization of IMI-1 beta-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae.
Characterization of IMI-1 beta-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae.
Characterization of IMI-1 beta-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae.
Characterization of IMI-1 beta-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae.
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