Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
subclass B1 metallo-beta-lactamase IMP-100
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaIMP-100 | Card DatabaseReference Gene CatalogReslit | 3 | CARBAPENEM, carbapenems | Pseudomonas aeruginosa | Bulgaria | 2023 | OR004774.1 | WHO54936.1 |
| blaIMP-101 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Aquipseudomonas alcaligenes | - | - | OR063824.1 | WIF03690.1 |
| blaIMP-102 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Pseudomonas asiatica | - | - | OR367336.1 | WLF01979.1 |
| blaIMP-104 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Pseudomonas alloputida | - | - | PQ218333.1 | XGD01539.1 |
| blaIMP-105 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Pseudomonas aeruginosa | - | - | PQ394548.1 | XHO32891.1 |
| blaIMP-106 | Reference Gene Catalog | 1 | CARBAPENEM | Pseudomonas aeruginosa | - | - | PQ493434.1 | XJP49378.1 |
| blaIMP-107 | Reference Gene Catalog | 1 | CARBAPENEM | Enterobacter hormaechei | - | - | PQ834532.1 | XLZ96867.1 |
| blaIMP-108 | Reference Gene Catalog | 1 | CARBAPENEM | Citrobacter amalonaticus | - | - | PQ834533.1 | XLZ96868.1 |
| blaIMP-109 | Reference Gene Catalog | 1 | CARBAPENEM | Enterobacter asburiae | - | - | PQ834534.1 | XLZ96869.1 |
| blaIMP-110 | Reference Gene Catalog | 1 | CARBAPENEM | Pseudomonas aeruginosa | - | - | PV035074.1 | XNY96397.1 |
| blaIMP-111 | Reference Gene CatalogReslit | 2 | CARBAPENEM, carbapenems | Pseudomonas aeruginosa | Bolivia | 2025 | PV055916.1 | XPA12121.1 |
| blaIMP-112 | Reference Gene Catalog | 1 | CARBAPENEM | Pseudomonas aeruginosa | - | - | ACCPCJ010000195.1 | EQF4405858.1 |
| blaIMP-17 | Card DatabaseReference Gene CatalogResFinder Database | 5 | MEROPENEM, ERTAPENEM +13 | Pseudomonas aeruginosa | - | - | AJ512502.1 | CAD55935.1 |
| blaIMP-23 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | MEROPENEM, ERTAPENEM +14 | Citrobacter freundii +2 | Spain|China|Taiwan | 2025 | DQ417222.1 | ABD85195.1 |
| blaIMP-32 | Card DatabaseReference Gene CatalogResFinder Database | 4 | MEROPENEM, ERTAPENEM +13 | Klebsiella pneumoniae | - | - | JQ002629.1 | AFR33816.1 |
| blaIMP-36 | Reference Gene Catalog | 1 | CARBAPENEM | Pseudomonas aeruginosa | - | - | PX488331.1 | YCK18009.1 |
| blaIMP-38 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | MEROPENEM, ERTAPENEM +17 | Klebsiella pneumoniae +2 | Australia, China, Greece | 2016, 2017, 2018, 2020, 2022 | HQ875573.1 | AEN75249.1 |
| blaIMP-39 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Pseudomonas aeruginosa | - | - | MK507818.1 | QBC73593.1 |
| blaIMP-46 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Pseudomonas putida | - | - | MK507819.1 | QBC73594.1 |
| blaIMP-48 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | MEROPENEM, ERTAPENEM +14 | Pseudomonas aeruginosa | - | 2019 | KM087857.1 | AIT76110.1 |
| blaIMP-49 | Card DatabaseReference Gene CatalogResFinder Database | 4 | MEROPENEM, ERTAPENEM +13 | Pseudomonas aeruginosa | - | - | KP681694.1 | AKO63210.1 |
| blaIMP-50 | Reference Gene Catalog | 1 | CARBAPENEM | Serratia marcescens | - | - | JAXAEM010000010.1 | MDX7491165.1 |
| blaIMP-51 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | MEROPENEM, ERTAPENEM +14 | Pseudomonas aeruginosa | Japan|Nepal|Vietnam | 2017 | LC031883.1 | BAQ56016.1 |
| blaIMP-52 | Card DatabaseReference Gene CatalogResFinder Database | 4 | MEROPENEM, ERTAPENEM +13 | Escherichia coli | - | - | LC055762.1 | BAR80870.1 |
| blaIMP-53 | Card DatabaseReference Gene CatalogResFinder Database | 5 | MEROPENEM, ERTAPENEM +13 | Pseudomonas aeruginosa | - | - | HM106457.1 | ADI49230.1 |
| blaIMP-54 | Card DatabaseReference Gene CatalogResFinder Database | 5 | MEROPENEM, ERTAPENEM +13 | Pseudomonas aeruginosa | - | - | KU052795.1 | ALN95135.1 |
| blaIMP-56 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | MEROPENEM, ERTAPENEM +15 | Pseudomonas aeruginosa | Mexico | 2018 | KU315553.1 | ALT53802.1 |
| blaIMP-58 | Card DatabaseReference Gene CatalogResFinder Database | 5 | MEROPENEM, ERTAPENEM +13 | Pseudomonas putida | - | - | KU647281.1 | AMJ16609.1 |
| blaIMP-60 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | MEROPENEM, ERTAPENEM +14 | Enterobacter cloacae | Japan | 2021 | LC159227.1 | BAV14383.1 |
| blaIMP-61 | Card DatabaseReference Gene CatalogResFinder Database | 5 | MEROPENEM, ERTAPENEM +13 | Acinetobacter baumannii | - | - | KX462700.1 | ANQ38580.1 |
| blaIMP-62 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | MEROPENEM, ERTAPENEM +15 | Pseudomonas aeruginosa | Mexico | 2018 | KX753224.1 | AOE46845.1 |
| blaIMP-63 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | MEROPENEM, ERTAPENEM +14 | Pseudomonas aeruginosa +1 | Paris|Rouen|France, Italy|France|Portugal|Spain|Brazil | 2019 | KX821663.1 | AOR06148.1 |
| blaIMP-64 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | MEROPENEM, ERTAPENEM +14 | Proteus mirabilis +3 | Europe | 2025 | KX949735.2 | AOV81905.1 |
| blaIMP-66 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | MEROPENEM, ERTAPENEM +14 | Escherichia coli +1 | Japan | 2021 | LC190726.1 | BAV78863.1 |
| blaIMP-67 | Card DatabaseReference Gene CatalogResFinder Database | 5 | MEROPENEM, ERTAPENEM +13 | Providencia rettgeri | - | - | MF281100.1 | ARX71247.1 |
| blaIMP-69 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Providencia sp. | - | - | MF678349.1 | ATJ25943.1 |
| blaIMP-70 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | MEROPENEM, ERTAPENEM +14 | Pseudomonas aeruginosa +3 | Japan | 2020, 2022 | MG748725.1 | AUM56801.1 |
| blaIMP-71 | Card DatabaseReference Gene CatalogResFinder Database | 5 | MEROPENEM, ERTAPENEM +13 | Pseudomonas aeruginosa | - | - | MG818167.1 | AUS29441.1 |
| blaIMP-73 | Card DatabaseReference Gene CatalogResFinder Database | 5 | MEROPENEM, ERTAPENEM +13 | Pseudomonas aeruginosa | - | - | MH021848.1 | AVK78200.1 |
| blaIMP-74 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | MEROPENEM, ERTAPENEM +14 | Pseudomonas aeruginosa +1 | Peru | 2025 | MH243349.1 | AWI33303.1 |
| blaIMP-75 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | MEROPENEM, ERTAPENEM +14 | Pseudomonas aeruginosa | - | 2022 | MH243350.1 | AWI33304.1 |
| blaIMP-76 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Pseudomonas aeruginosa | - | - | LC389062.1 | BBE43066.1 |
| blaIMP-77 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Pseudomonas aeruginosa | - | - | LC389063.1 | BBE43067.1 |
| blaIMP-78 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Pseudomonas aeruginosa | - | - | LC389064.1 | BBE43068.1 |
| blaIMP-79 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Pseudomonas aeruginosa | - | - | MG873561.1 | AXH79883.1 |
| blaIMP-80 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Pseudomonas aeruginosa | - | - | LC420635.1 | BBG06478.1 |
| blaIMP-81 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | uncultured bacterium | - | - | MN017299.1 | QDC28548.1 |
| blaIMP-82 | Card DatabaseReference Gene CatalogReslit | 4 | CARBAPENEM, carbapenems | Pseudomonas aeruginosa | Germany | 2019 | MN057782.1 | QDC28549.1 |
| blaIMP-83 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Pseudomonas aeruginosa | - | - | MN104595.1 | QDM39440.1 |
| blaIMP-84 | Card DatabaseReference Gene CatalogReslit | 5 | CARBAPENEM, carbapenems | Pseudomonas aeruginosa +1 | Boston, MA|Orange, CA, Idaho | 2022, 2023 | MN219692.1 | QDY98369.1 |
| blaIMP-85 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Pseudomonas aeruginosa | - | - | MN510335.1 | QEV89919.1 |
| blaIMP-86 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Pseudomonas aeruginosa | - | - | MT241520.1 | QIZ64888.1 |
| blaIMP-87 | Card DatabaseReference Gene CatalogReslit | 3 | CARBAPENEM, imipenem +1 | Pseudomonas aeruginosa | - | 2022 | MT241521.1 | QIZ64889.1 |
| blaIMP-88 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Pseudomonas aeruginosa | - | - | LC558310.1 | BCH68486.1 |
| blaIMP-89 | Card DatabaseReference Gene CatalogReslit | 4 | CARBAPENEM, carbapenems | Pseudomonas putida +2 | China | 2023 | MN961670.1 | QIZ22804.1 |
| blaIMP-90 | Card DatabaseReference Gene CatalogReslit | 3 | CARBAPENEM, carbapenems | Pseudomonas aeruginosa +2 | China | 2023 | MW811441.1 | QTG68658.1 |
| blaIMP-91 | Card DatabaseReference Gene CatalogReslit | 4 | CARBAPENEM, carbapenems | Pseudomonas aeruginosa +2 | China | 2023 | CP059995.1 | QMX80023.1 |
| blaIMP-92 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Pseudomonas aeruginosa | - | - | OM280335.1 | UJT87582.1 |
| blaIMP-93 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Pseudomonas aeruginosa | - | - | JAKEVW010000034.1 | MCF1770911.1 |
| blaIMP-94 | Card DatabaseReference Gene CatalogReslit | 4 | CARBAPENEM, imipenem | Achromobacter xylosoxidans +1 | Europe | 2025 | OM460740.1 | UKC75980.1 |
| blaIMP-95 | Card DatabaseReference Gene CatalogReslit | 4 | CARBAPENEM, carbapenems | Acinetobacter baumannii +1 | Europe | 2025 | OM933716.1 | UNN26052.1 |
| blaIMP-96 | Card DatabaseReference Gene CatalogReslit | 5 | CARBAPENEM, carbapenems | Stenotrophomonas sp. +3 | China, Europe | 2023, 2026 | ON419293.1 | UPY65822.1 |
| blaIMP-97 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Klebsiella oxytoca | - | - | LC727551.1 | BDR24828.1 |
| blaIMP-99 | Card DatabaseReference Gene Catalog | 2 | CARBAPENEM | Pseudomonas aeruginosa | - | - | OQ533023.1 | WEG44269.1 |
| blaIMP-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 138 | carbapenems, imipenem +37 | Pseudomonas aeruginosa +57 | Korea, Singapore, Japan, Brazil, Japan|Italy|Portugal|South Korea|Taiwan|France|Greece|USA|Turkey|Singapore|Brazil|Argentina|South America|Southern Europe|Southeast Asia, China, Taiwan, Daejeon, Korea, South Korea, France, Iran, Germany, Northern Taiwan, Tehran, Egypt, Italy, India, South of Brazil, Netherlands, United States|United Kingdom|Spain, Mainland China, Europe, Northern China, Vietnam, Nepal, Tokyo, Pakistan, Colombia, Indonesia, Texas, USA, China|France|Japan|Palestine|Russia|United States|Global|South America|Europe|Asia|Brazil|Italy|Greece|Vietnam|Afghanistan|Algeria, India|France|Italy|Japan|Portugal|Iran|United States|Mexico|Global, Tokyo, Japan|Japan, Nigeria, Brazilian Amazon Region, Ghana, Greece, Brazil|India|Sweden|USA|Argentina|Italy|Japan, Anhui province, Japan|France|United Kingdom|North America|South America|Europe|Asia/Oceania|Africa, Italy|Taiwan|Spain|China|Australia|United States|Egypt|Bolivia, Zhejiang, China|China, various countries|Global, South Africa, Mexico|Mexico City, Global, Iraq, Switzerland, Mexico, Asia|Australia|Europe|North America|South East Asia|global|Southeast Asia, Lebanon, Europe|United States, India|United States, Europe|Ukraine|Myanmar|Netherlands|United States|India|Uganda|Poland|Pakistan|Tanzania, Bangladesh | 1994, 2002, 2003, 2004, 2005, 2006, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AJ223604.1 | CAA11471.1 |
| blaIMP-18 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 14 | carbapenems, MEROPENEM +17 | Pseudomonas aeruginosa +3 | United States, Puerto Rico, Mexico, Costa Rica|United Kingdom|Netherlands, Costa Rica, Paraguay, United States|Canada|Europe, Latin America|Costa Rica | 2006, 2012, 2016, 2018, 2020, 2021, 2023, 2025 | JN596991.1 | AEQ73520.1 |
| blaIMP-26 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 24 | MEROPENEM, ERTAPENEM +20 | Pseudomonas aeruginosa +10 | Chongqing, China, Australia, Japan|Nepal|Vietnam, Shanghai, China, China, Philippines, Zhejiang, China|China, Global, Africa|Asia|Europe|Latin America|North America, Asia|Australia|Europe|North America|South East Asia|global|Southeast Asia | 2010, 2012, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | GU045307.1 | ACY01749.1 |
| blaIMP-29 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | carbapenems, MEROPENEM +15 | Pseudomonas aeruginosa +2 | France, Sweden | 2012, 2018 | JQ041634.1 | AFG25462.1 |
| blaIMP-34 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | MEROPENEM, ERTAPENEM +15 | Klebsiella oxytoca +9 | Japan, Japan|Nepal|Vietnam | 2013, 2016, 2017, 2022 | AB715422.2 | BAP75826.1 |
| blaIMP-59 | Card DatabaseReference Gene CatalogResFinder Database | 5 | MEROPENEM, ERTAPENEM +13 | Escherichia coli | - | 2025 | NG_055477.1 | WP_094009805.1 |
| blaIMP-65 | Card DatabaseReference Gene CatalogReslit | 4 | carbapenems, CARBAPENEM | Pseudomonas aeruginosa | Thailand | 2019 | NG_066508.1 | WP_150823469.1 |
| blaIMP-9 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | MEROPENEM, ERTAPENEM +19 | Pseudomonas aeruginosa PA96 +2 | China, Guangzhou, China, Mainland China, Guangdong, China | 2006, 2009, 2013, 2016, 2023, 2024 | KC543497.1 | AAK59385.1 |
| blaIMP | Reslit | 222 | carbapenems, cephalosporins +18 | Pseudomonas aeruginosa +80 | Japan, Brazil, Italy, Canada, United States, Washington|Alaska|New Jersey|Malaysia|Mexico|Israel, Singapore, Global|India|Spain, Iran, Germany, Nepal, China, Mexico, Korea, Middle East|Afghanistan|Iraq|Egypt|Pakistan|Lebanon|Iran|Jordan|Persian Gulf Countries|United Arab Emirates|Kuwait|Qatar|Bahrain|Oman|Saudi Arabia|Turkey, United States|Europe|Asia|Africa|South America|India|United Kingdom|Egypt|Belgium|Italy|China|United Arab Emirates, Saudi Arabia, Egypt, Europe, global, Bangladesh, Europe|seafood, Norway, France, Shanghai, China, Thailand, India, Japan|Myanmar|Singapore|Thailand, Mexico City, Northern California, Lebanon, Ireland, Peru, United States|India|Turkey|Europe, Taiwan, Brazilian Amazon|Brazil, South Korea, Spain, Iraq, Brazil|Czech Republic|Germany|India|Japan|Kenya|Kuwait|Nigeria|Philippines|South Korea|Thailand|United States, Colombia, Eastern Cape Province, Republic of South Africa|South Africa, Global|global|Turkey, Europe|Israel, Eastern Cape Province, Turkey, UK|USA|France|Spain|Italy|Europe, Sudan, South Africa, Malaysia, Europe|Iraq, Asia|Pacific, Asia|Hong Kong, Europe|USA|Portugal|Germany|Australia|China|India|Pakistan|Sweden|Colorado, Pakistan, Malawi, Shanghai, Morocco, Northern China, various countries|Global, China|global, Colombia|Chile|Argentina|Mexico|Brazil, Northern Pacific Ocean|Norway Sea|Europe, Romania, Virginia, Uganda, Ivory Coast|Ghana, Philippines, China|Romania|Italy|Other countries, Chongqing|Southwestern China, Nigeria, Türkiye, Italy|Greece, Europe|Ukraine, Kenya, USA|China|Japan|Spain|United Kingdom|Germany|France|South Korea|Netherlands|Viet Nam|Laos|Canada|Czech Republic|Argentina|Brazil|Belgium|Denmark|Iran|Australia|Croatia|Ghana|Mexico|Missing, United States|China|Colombia|Argentina|Chile|Australia|Singapore, Argentina, Ethiopia, Poland, England, Europe|Switzerland, Southwest Nigeria, Asia|Australia|Europe|North America|South East Asia|global|Southeast Asia, farms|wastewater treatment plants|surface water, United Arab Emirates, Tunisia, India|Sweden|China|Hong Kong | 1994, 1995, 1999, 2000, 2002, 2003, 2004, 2005, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AJ223604 | - |
| blaIMP-2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 16 | ampicillin, cephalothin +23 | Acinetobacter baumannii AC-54/97 +7 | Italy, Japan, Japan|Italy|Portugal|South Korea|Taiwan|France|Greece|USA|Turkey|Singapore|Brazil|Argentina|South America|Southern Europe|Southeast Asia, Germany, India|France|Italy|Japan|Portugal|Iran|United States|Mexico|Global, Nigeria, Iran, various countries|Global, Mexico|Mexico City | 2000, 2004, 2005, 2010, 2013, 2014, 2020, 2021, 2022, 2023, 2024 | AJ243491 | CAB94707.1 |
| blaIMP-3 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | ampicillin, ceftazidime +17 | Escherichia coli +1 | Japan|Italy|Portugal|South Korea|Taiwan|France|Greece|USA|Turkey|Singapore|Brazil|Argentina|South America|Southern Europe|Southeast Asia | 2000, 2005 | AB010417 | BAA77393.1 |
| blaIMP-4 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 106 | imipenem, meropenem +34 | Acinetobacter spp. +48 | Hong Kong, United States, Australia, Malaysia, China, Germany, Shandong Province, China, Queensland, Australia, Shandong, China, United States|Colombia|Australia|India|China|France|Germany|Egypt|Switzerland|Pakistan|Morocco|Tunisia|Taiwan, Eastern China, Saudi Arabia, Heilongjiang Province, China, India|France|Italy|Japan|Portugal|Iran|United States|Mexico|Global, Northeast China, Southwest China, Singapore, Boston, MA|Orange, CA, Global, Australia|Melbourne, Australia, Greece, Zhejiang, China|China, various countries|Global, New Caledonia, China|Colombia|Lebanon|Singapore|United States, Bangladesh, Boston|California|New York, Mexico|Mexico City, South China, Hangzhou, Zhejiang Province, China, Europe, China|Southwest China, Asia|Australia|Europe|North America|South East Asia|global|Southeast Asia, China|Europe|Americas|Asia|North Africa|Middle East, India|United States, China|Europe|India|United Arab Emirates|Greece|Switzerland, Henan, China, China|Japan|Australia | 2001, 2003, 2006, 2008, 2009, 2012, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AF244145 | AAK13078.1 |
| blaIMP-6 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 32 | carbapenems, MEROPENEM +26 | Serratia marcescens +9 | Japan|Italy|Portugal|South Korea|Taiwan|France|Greece|USA|Turkey|Singapore|Brazil|Argentina|South America|Southern Europe|Southeast Asia, Europe|Asia|North America|South America, South Korea, Japan, Korea, Osaka, Japan, various countries|Global, Mexico|Mexico City, China|Japan|Australia | 2001, 2005, 2012, 2013, 2015, 2016, 2017, 2018, 2019, 2021, 2022, 2023, 2024, 2025, 2026 | AB040994 | BAB15941.1 |
| blaIMP-8 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 37 | aztreonam, carbapenems +34 | Klebsiella pneumoniae +28 | Taiwan, China, Taiwan|North America|South America|Europe|Asia|Australia, Chongqing, China, Germany, Japan|Taiwan, France, Global|global|Turkey, Spain, various countries|Global, Asia/South Pacific|Europe|Latin America|Middle East/Africa|North America, Europe, Portugal, Asia|Australia|Europe|North America|South East Asia|global|Southeast Asia, Spain|China|Taiwan | 2001, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2018, 2019, 2021, 2022, 2023, 2024, 2025 | AF322577 | AAK13430.1 |
| blaIMP-7 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 17 | carbapenems, ceftazidime +18 | Pseudomonas aeruginosa +4 | Canada, Argentina, Calgary Health Region, Malaysia, Germany, Japan, Europe, Indonesia, Europe|Canada, Singapore, Asia|Australia|Europe|North America|South East Asia|global|Southeast Asia | 2002, 2005, 2007, 2010, 2012, 2014, 2015, 2016, 2019, 2021, 2023, 2025 | AF318077 | AAK12087.1 |
| blaIMP-10 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 16 | carbapenems, MEROPENEM +23 | Pseudomonas aeruginosa +5 | Japan, Japan|Italy|Portugal|South Korea|Taiwan|France|Greece|USA|Turkey|Singapore|Brazil|Argentina|South America|Southern Europe|Southeast Asia, Mainland China, South Korea, Japan|Nepal|Vietnam, Pakistan, Brazil, various countries|Global, Europe | 2002, 2005, 2010, 2015, 2016, 2017, 2022, 2023, 2025 | AB074433|AB074434|AB074435 | BAB72069.1 |
| blaIMP-5 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | MEROPENEM, ERTAPENEM +17 | Acinetobacter baumannii +2 | India|France|Italy|Japan|Portugal|Iran|United States|Mexico|Global, various countries|Global | 2002, 2012, 2020, 2022 | AF290912.1 | AAK27847.1 |
| blaIMP-12 | Card DatabaseReference Gene CatalogResFinder Database | 4 | MEROPENEM, ERTAPENEM +13 | Pseudomonas putida | - | 2003 | AJ420864.1 | CAD12765.1 |
| blaIMP-13 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 19 | MEROPENEM, ERTAPENEM +23 | Pseudomonas aeruginosa +9 | Italy, Germany, Spain|Portugal, Spain, Zagreb, Croatia, Singapore, Global, Upper Austria, Europe, Asia|Australia|Europe|North America|South East Asia|global|Southeast Asia, Europe|United States | 2003, 2005, 2008, 2014, 2022, 2023, 2024, 2025 | AJ550807.1 | CAD80251.1 |
| blaIMP-16 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 10 | carbapenems, cephalosporins +15 | Pseudomonas aeruginosa +3 | Brazil, Germany, Peru|Spain | 2004, 2010, 2012, 2014, 2021, 2024 | AJ584652 | CAE48334.1 |
| blaIMP-19 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 13 | ceftazidime, cefoxitin +22 | Aeromonas caviae +9 | France, Japan|Taiwan, various countries|Global, Poland, Global, USA|China|India|Thailand|Brazil|Hungary|South Africa|Egypt|Tunisia|Europe|Asia, Taiwan | 1994, 2007, 2016, 2017, 2018, 2022, 2023, 2024 | EF118171 | ABM67078.1 |
| blaIMP-15 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 10 | imipenem, meropenem +17 | Pseudomonas aeruginosa +4 | Mexico|United States, Germany, Japan|Nepal|Vietnam, Spain, United States|Canada|Europe, Global | 2008, 2014, 2017, 2022, 2023 | EF184216|AY553333 | AAT49070.1 |
| blaIMP-24 | Card DatabaseReference Gene CatalogResFinder Database | 4 | MEROPENEM, ERTAPENEM +13 | Serratia marcescens | - | 2008 | EF192154.1 | ABM68358.1 |
| blaIMP-22 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | MEROPENEM, ERTAPENEM +16 | Pseudomonas fluorescens +5 | United States|Europe|Asia|Africa|South America|India|United Kingdom|Egypt|Belgium|Italy|China|United Arab Emirates, Portugal, Spain | 2009, 2016, 2021, 2022 | DQ361087.2 | ABC88434.1 |
| blaIMP-14 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | carbapenems, MEROPENEM +16 | Pseudomonas aeruginosa +6 | Norway|Sweden, Germany, Thailand, Japan|Nepal|Vietnam, Mexico|Mexico City | 2010, 2011, 2014, 2016, 2017, 2021, 2023, 2024 | FN397623|FN397626|FN397624|FN397625|FN397622|FN397621|FN397620|FN397619|FN397618|FN397628|FN397627 | AAT49068.1 |
| blaIMP-11 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 13 | MEROPENEM, ERTAPENEM +19 | Acinetobacter baumannii +9 | Japan, Tokyo, Japan|Japan, various countries|Global, Mexico|Mexico City, Sweden, China | 2011, 2015, 2020, 2021, 2022, 2023, 2024, 2025 | AB074436.1 | BAB72072.1 |
| blaIMP-20 | Card DatabaseReference Gene CatalogResFinder Database | 4 | MEROPENEM, ERTAPENEM +13 | Pseudomonas aeruginosa | - | 2011 | AB196988.1 | BAD81061.1 |
| blaIMP-21 | Card DatabaseReference Gene CatalogResFinder Database | 4 | MEROPENEM, ERTAPENEM +13 | Pseudomonas aeruginosa | - | 2011 | AB204557.1 | BAD89802.1 |
| blaIMP-28 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | ampicillin, ceftazidime +19 | Klebsiella oxytoca +2 | Spain, Spain|Portugal | 2012, 2021, 2022 | JQ407409 | AFG73659.1 |
| blaIMP-25 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | meropenem, doripenem +17 | E. coli +2 | South Korea, India | 2012, 2019 | EU541448 | ACB41775.1 |
| blaIMP-37 | Card DatabaseReference Gene CatalogResFinder Database | 4 | MEROPENEM, ERTAPENEM +13 | Pseudomonas aeruginosa | - | 2012 | JX131372.1 | AFP97028.1 |
| blaIMP-35 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | MEROPENEM, ERTAPENEM +15 | Pseudomonas aeruginosa +1 | Mexico | 2013, 2024 | JF816544.1 | AFO59566.1 |
| blaIMP-40 | Card DatabaseReference Gene CatalogResFinder Database | 4 | MEROPENEM, ERTAPENEM +13 | Pseudomonas aeruginosa | - | 2013 | AB753457.1 | BAM62794.1 |
| blaIMP-41 | Card DatabaseReference Gene CatalogResFinder Database | 4 | MEROPENEM, ERTAPENEM +13 | Pseudomonas aeruginosa | - | 2013 | AB753458.1 | BAM62795.1 |
| blaIMP-42 | Card DatabaseReference Gene CatalogResFinder Database | 4 | MEROPENEM, ERTAPENEM +13 | Acinetobacter soli | - | 2013 | AB753456.1 | BAM62793.1 |
| blaIMP-43 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | carbapenems, MEROPENEM +15 | Escherichia coli +1 | Japan, Japan|Nepal|Vietnam, Indonesia, Egypt | 2013, 2017, 2019, 2025 | AB777500|AB777501 | BAM98935.1 |
| blaIMP-44 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | carbapenems, MEROPENEM +15 | Escherichia coli +1 | Japan, Japan|Nepal|Vietnam | 2013, 2017 | AB777500|AB777501 | BAM98942.1 |
| blaIMP-30 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, MEROPENEM +14 | Escherichia coli +1 | Russia | 2013 | DQ522237 | ABF70513.1 |
| blaIMP-33 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | carbapenems, MEROPENEM +14 | Pseudomonas aeruginosa +1 | Italy | 2013 | JN848782 | AEU17778.1 |
| bla(IMP-8) | Reslit | 2 | imipenem, meropenem +3 | Raoultella planticola +1 | Taiwan, China | 2014, 2025 | KP097712 | - |
| blaIMP-45 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 13 | MEROPENEM, ERTAPENEM +19 | Pseudomonas aeruginosa | China, Guangdong, China | 2014, 2021, 2022, 2023, 2025 | KJ510410.1 | AIA58910.1 |
| blaIMP-31 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | carbapenems, MEROPENEM +14 | Enterobacteriaceae +2 | Germany | 2014, 2015 | KF148593.1 | AGS82587.1 |
| blaIMP-14a | Reslit | 2 | carbapenems | Klebsiella pneumoniae +1 | Thailand | 2015, 2020 | LN890476|LN890477|LN890335|KJ406505|KJ406506 | - |
| blaIMP-55 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | MEROPENEM, ERTAPENEM +16 | Acinetobacter baumannii | various countries|Global | 2016, 2017, 2022 | KT935306 | ALT07696.1 |
| blaIMP-27 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 14 | ertapenem, MEROPENEM +20 | Proteus mirabilis +14 | United States, Canada, Missouri, USA, China, Mexico, Asia|Australia|Europe|North America|South East Asia|global|Southeast Asia, Europe | 2016, 2020, 2021, 2022, 2023, 2024, 2025 | JF894248|KF501391 | AEH41427.1 |
| bla_IMP-1 | Reslit | 1 | carbapenems | Klebsiella pneumoniae +1 | Korea | 2016 | - | - |
| bla_IMP | Reslit | 10 | carbapenems, meropenem +5 | Acinetobacter baumannii +6 | Europe|Brazil|China|Switzerland|Iran|Puerto Rico|United States, South Africa, Egypt, Uganda, Valencia, Spain, United Kingdom, Iran, Tianjin|Southern Karnataka, Europe | 2016, 2020, 2021, 2023, 2024, 2025 | PRJEB52722|PRJEB54594 | - |
| IMP | Reslit | 18 | carbapenems, imipenem +1 | Acinetobacter baumannii +14 | Vietnam, South Korea, Delhi, India, Tanzania|Thailand|human|swine, India, North Carolina, Europe, Iran, Saudi Arabia, China, Japan, United States|Europe, United States|European Union, Europe|unknown | 2016, 2017, 2019, 2020, 2021, 2022, 2023, 2025 | KY706079|KY706080|KY753816 | - |
| bla_IMP-8 | Reslit | 1 | carbapenems | Klebsiella pneumoniae | Malaysia | 2017 | - | - |
| bla(IMP-27) | Reslit | 1 | imipenem, meropenem | Providencia rettgeri +2 | United States | 2018 | NOWA01000087.1|NOWC01000095.1 | - |
| bla(IMP) | Reslit | 5 | imipenem, meropenem +1 | Pseudomonas aeruginosa +4 | Iran, Kathmandu, Nepal, Tanzania, Quetta, Pakistan | 2017, 2021, 2022, 2023, 2024 | - | - |
| bla(IMP-1) | Reslit | 5 | carbapenems, meropenem +1 | Escherichia coli +3 | Japan, Iran, Europe|Switzerland, Europe | 2018, 2019, 2020, 2025 | CP017183.3|NZ_CP041734.1|CP031724|LN555650|MK933279|CP006788.1|AP019388.1|AP019386.1|AP019383.1 | - |
| bla(IMP-6) | Reslit | 1 | carbapenems | Escherichia coli | Japan | 2018 | - | - |
| blaIMP-68 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | carbapenems, MEROPENEM +14 | Klebsiella pneumoniae TA6363 +3 | Japan | 2019 | MF669572|AP019665|AP019666|AP019667|AP019668 | ASU31903.1 |
| bla(IMP-4) | Reslit | 8 | carbapenems, cephalosporins +4 | Escherichia coli ST216 +8 | Australia, China, Europe, Asia|China | 2021, 2022, 2023, 2024 | JABBCF000000001|MT232840|MT162140|MT162141|MT162142|MT162143|MT162144|MT180430|MT180431|MT180432|MT180433|MT180434|MT180435 | - |
| blaIMP-like | Reslit | 2 | ceftazidime, cefepime +3 | Escherichia coli +1 | Taiwan, China | 2021, 2026 | - | - |
| imp | Reslit | 1 | beta lactams | Pseudomonas aeruginosa | - | 2021 | - | - |
| bla(IMP-22) | Reslit | 1 | carbapenems | Klebsiella pneumoniae | Portugal | 2021 | - | - |
| blaIMP–4 | Reslit | 1 | imipenem, meropenem +7 | Klebsiella michiganensis | Europe | 2021 | JAHNZR000000000 | - |
| bla_IMP-4 | Reslit | 2 | carbapenems | Escherichia coli +1 | New South Wales, Australia, Wales | 2022, 2023 | PRJNA630096 | - |
| bla_IMP-45 | Reslit | 1 | carbapenems | Pseudomonas aeruginosa +1 | China | 2022 | CP090649|CP090650|CP090651|CP090648|CP090647 | - |
| bla(IMP-70) | Reslit | 1 | carbapenems | Providencia rettgeri +1 | Osaka, Japan | 2022 | LC670768|LC348383|AP025670|AP025671 | - |
| bla(IMP-56) | Reslit | 1 | carbapenems | Pseudomonas aeruginosa | Mexico | 2022 | CP102481.1 | - |
| bla(IMP-60) | Reslit | 1 | meropenem | Enterobacter asburiae | Japan | 2022 | AP024281|AP024282 | - |
| blaIMP-1 group | Reslit | 1 | carbapenems | Pseudomonas aeruginosa +1 | Colombia|India|Spain|France|Greece|Germany|Argentina|Croatia|China|Brazil|Mexico|Romania|Philippines|United States | 2022 | - | - |
| blaIMP-70b | Reslit | 1 | carbapenems | Enterobacter hormaechei | United Kingdom|UK | 2023 | PRJEB31034|ER2672819 | - |
| blaIMP-98 | Card DatabaseReference Gene CatalogReslit | 3 | carbapenems, CARBAPENEM | Pseudomonas aeruginosa | Japan | 2024 | AP029374|NC_002516.2|AP024167|CP000645|CP079815 | BDU49371.1 |
| blaIMP -like | Reslit | 1 | ertapenem, meropenem +1 | Klebsiella pneumoniae | Southwest Amazon region|Rondônia|Brazil | 2024 | - | - |
| bla(IMP-26) | Reslit | 1 | meropenem, imipenem +4 | Enterobacter xiangfangensis +1 | China | 2025 | CP011611|CP083755|PRJNA993413|PRJNA993565 | - |
| blaIMP-1b | ResFinder Database | 1 | MEROPENEM, ERTAPENEM +12 | Pseudomonas aeruginosa | - | - | MK388919 | - |
Structure of In31, a blaIMP-containing Pseudomonas aeruginosa integron phyletically related to In5, which carries an unusual array of gene cassettes.
The study characterizes the blaIMP gene, which encodes the IMP-1 metallo-beta-lactamase, and identifies several other resistance genes including aacA4, catB6, and qacG, all of which were experimentally validated for their roles in antimicrobial resistance.
Carbapenem Derivatives as Potential Inhibitors of Various beta-lactamases, Including Class B Metallo-beta-lactamases.
The study identifies J-110,441 as a potent inhibitor of various beta-lactamases, including the IMP-1 metallo-beta-lactamase, which is responsible for carbapenem resistance in several bacterial species.
Convenient Test for Screening Metallo-beta-lactamase-Producing Gram-Negative Bacteria by Using Thiol Compounds
The study describes a disk diffusion test using thiol compounds to detect IMP-1 metallo-beta-lactamase-producing gram-negative bacteria, highlighting the role of blaIMP in conferring resistance to β-lactam antibiotics.
Detection of carbapenemase-producing Acinetobacter baumannii in a hospital.
The study identifies the carbapenemase gene blaIMP in carbapenem-resistant Acinetobacter baumannii strains, demonstrating its role in conferring resistance to multiple β-lactam antibiotics and aminoglycosides.
Characterization of the metallo-beta-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of blaIMP allelic variants carried by gene cassettes of different phylogeny.
The study identifies blaIMP-2, an allelic variant of blaIMP, as a metallo-beta-lactamase gene responsible for resistance to multiple beta-lactam antibiotics in Acinetobacter baumannii AC-54/97.
Characterization of the metallo-beta-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of bla(IMP) allelic variants carried by gene cassettes of different phylogeny.
Characterization of the metallo-beta-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of bla(IMP) allelic variants carried by gene cassettes of different phylogeny.
Characterization of the metallo-beta-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of bla(IMP) allelic variants carried by gene cassettes of different phylogeny.
Characterization of the metallo-beta-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of bla(IMP) allelic variants carried by gene cassettes of different phylogeny.
Amino acid substitutions in a variant of IMP-1 metallo-beta-lactamase.
The study identifies the blaIMP-3 gene, a variant of the IMP-1 metallo-beta-lactamase, which confers resistance to β-lactam antibiotics through specific amino acid substitutions. The mutation at nucleotide 640 (G→A) leads to a Ser→Gly substitution at position 196, enhancing resistance to ampicillin and ceftazidime.
Amino acid substitutions in a variant of IMP-1 metallo-beta-lactamase.
Amino acid substitutions in a variant of IMP-1 metallo-beta-lactamase.
Amino acid substitutions in a variant of IMP-1 metallo-beta-lactamase.
Amino acid substitutions in a variant of IMP-1 metallo-beta-lactamase.
IMP-4, a novel metallo-beta-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998.
The study identifies IMP-4, a novel metallo-beta-lactamase from Acinetobacter spp. that confers resistance to imipenem and meropenem.
IMP-4, a novel metallo-beta-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998.
IMP-4, a novel metallo-beta-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998.
IMP-4, a novel metallo-beta-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998.
IMP-4, a novel metallo-beta-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998.
Plasmid-encoded metallo-beta-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem.
The study identifies IMP-6, a plasmid-encoded metallo-beta-lactamase that confers resistance to carbapenems, particularly meropenem, through a single point mutation resulting in an amino acid substitution (Ser-196 to Gly).
Plasmid-encoded metallo-beta-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem.
Plasmid-encoded metallo-beta-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem.
Plasmid-encoded metallo-beta-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem.
Plasmid-encoded metallo-beta-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem.
Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae.
The study identifies a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae. IMP-8 differs from IMP-2 by four nucleotide substitutions leading to two amino acid changes and is carried on an integron-borne gene cassette.
Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae.
Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae.
Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae.
Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae.
Outbreak of infection with multidrug-resistant Klebsiella pneumoniae carrying blaIMP-8 in a university medical center in Taiwan.
The study identifies blaIMP-8, a metallo-beta-lactamase gene, as a cause of multidrug-resistant Klebsiella pneumoniae infections in a university medical center in Taiwan.
Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new blaIMP allele, blaIMP-7.
The study identifies a new blaIMP allele, blaIMP-7, which confers resistance to carbapenems and ceftazidime in Pseudomonas aeruginosa.
Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new bla(IMP) allele, bla(IMP-7).
Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new bla(IMP) allele, bla(IMP-7).
Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new bla(IMP) allele, bla(IMP-7).
Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new bla(IMP) allele, bla(IMP-7).
Detection of a variant metallo-beta-lactamase, IMP-10, from two unrelated strains of Pseudomonas aeruginosa and an alcaligenes xylosoxidans strain.
The study identifies a variant metallo-beta-lactamase, IMP-10, which differs from IMP-1 by a single amino acid substitution (Val49 to Phe) and exhibits reduced penicillin-hydrolyzing activity.
Detection of a variant metallo-beta-lactamase, IMP-10, from two unrelated strains of Pseudomonas aeruginosa and an alcaligenes xylosoxidans strain.
Detection of a variant metallo-beta-lactamase, IMP-10, from two unrelated strains of Pseudomonas aeruginosa and an alcaligenes xylosoxidans strain.
Detection of a variant metallo-beta-lactamase, IMP-10, from two unrelated strains of Pseudomonas aeruginosa and an alcaligenes xylosoxidans strain.
Detection of a variant metallo-beta-lactamase, IMP-10, from two unrelated strains of Pseudomonas aeruginosa and an alcaligenes xylosoxidans strain.
Occurrence of a multidrug-resistant Pseudomonas aeruginosa clone in different hospitals in Rio de Janeiro, Brazil.
The study identifies the presence of metallo-beta-lactamase (blaIMP and blaVIM) producing Pseudomonas aeruginosa isolates in Brazil, highlighting the emergence of multidrug-resistant clones in hospitals in Rio de Janeiro.
Evaluation of a new Etest for detecting metallo-beta-lactamases in routine clinical testing.
The study evaluates a new Etest for detecting metallo-beta-lactamases, identifying blaIMP-1 and blaVIM genes as responsible for carbapenem resistance in various bacterial species.
Molecular characterization of bla(IMP-5), a new integron-borne metallo-beta-lactamase gene from an Acinetobacter baumannii nosocomial isolate in Portugal.
Molecular characterization of bla(IMP-5), a new integron-borne metallo-beta-lactamase gene from an Acinetobacter baumannii nosocomial isolate in Portugal.
Molecular characterization of bla(IMP-5), a new integron-borne metallo-beta-lactamase gene from an Acinetobacter baumannii nosocomial isolate in Portugal.
Molecular characterization of bla(IMP-5), a new integron-borne metallo-beta-lactamase gene from an Acinetobacter baumannii nosocomial isolate in Portugal.
Epidemiology of rifampin ADP-ribosyltransferase (arr-2) and metallo-beta-lactamase (blaIMP-4) gene cassettes in class 1 integrons in Acinetobacter strains isolated from blood cultures in 1997 to 2000.
The study identifies the blaIMP-4 gene encoding the metallo-beta-lactamase IMP-4 and the arr-2 gene encoding the rifampin ADP-ribosyltransferase in Acinetobacter strains, both located in class 1 integrons. These genes confer resistance to imipenem and rifampin, respectively.
IMP-12, a new plasmid-encoded metallo-beta-lactamase from a Pseudomonas putida clinical isolate.
IMP-12, a new plasmid-encoded metallo-beta-lactamase from a Pseudomonas putida clinical isolate.
IMP-12, a new plasmid-encoded metallo-beta-lactamase from a Pseudomonas putida clinical isolate.
IMP-12, a new plasmid-encoded metallo-beta-lactamase from a Pseudomonas putida clinical isolate.
VIM- and IMP-type metallo-beta-lactamase-producing Pseudomonas spp. and Acinetobacter spp. in Korean hospitals.
The study identified bla VIM-2 and bla IMP-1 alleles as the primary metallo-beta-lactamase genes responsible for carbapenem resistance in Pseudomonas and Acinetobacter isolates in Korean hospitals.
Genetic characterization of a novel metallo-beta-lactamase gene, blaIMP-13, harboured by a novel Tn5051-type transposon disseminating carbapenemase genes in Europe: report from the SENTRY worldwide antimicrobial surveillance programme.
Genetic characterization of a novel metallo-beta-lactamase gene, blaIMP-13, harboured by a novel Tn5051-type transposon disseminating carbapenemase genes in Europe: report from the SENTRY worldwide antimicrobial surveillance programme.
Genetic characterization of a novel metallo-beta-lactamase gene, blaIMP-13, harboured by a novel Tn5051-type transposon disseminating carbapenemase genes in Europe: report from the SENTRY worldwide antimicrobial surveillance programme.
Genetic characterization of a novel metallo-beta-lactamase gene, blaIMP-13, harboured by a novel Tn5051-type transposon disseminating carbapenemase genes in Europe: report from the SENTRY worldwide antimicrobial surveillance programme.
Presence of Pseudomonas putida Strains Harboring Plasmids Bearing the Metallo-beta-lactamase Gene blaIMP in a Hospital in Japan.
The study identifies the presence of Pseudomonas putida strains harboring plasmids with the blaIMP gene, which confers resistance to carbapenems and cephalosporins. The blaIMP gene was transferable to Pseudomonas aeruginosa, highlighting the potential for horizontal gene transfer of carbapenem resistance.
Evaluation of the Hodge test and the imipenem-EDTA double-disk synergy test for differentiating metallo-beta-lactamase-producing isolates of Pseudomonas spp. and Acinetobacter spp.
The study evaluated the Hodge test and imipenem-EDTA double-disk synergy test for detecting metallo-beta-lactamase (MBL)-producing isolates of Pseudomonas and Acinetobacter. It identified blaIMP-1 and blaVIM-2 as the MBL genes responsible for carbapenem resistance.
Molecular epidemiology of sequential outbreaks of Acinetobacter baumannii in an intensive care unit shows the emergence of carbapenem resistance.
The study identifies several AMR genes, including aacC1, aadA1a, aacA4, blaOXA-20, and blaIMP, which confer resistance to various antibiotics in carbapenem-resistant Acinetobacter baumannii strains.
IMP-1 and a novel metallo-beta-lactamase, VIM-6, in fluorescent pseudomonads isolated in Singapore.
The study identifies blaIMP-1 and a novel metallo-beta-lactamase, VIM-6, in carbapenem-resistant Pseudomonas spp. isolates from Singapore. Both genes confer resistance to various beta-lactam antibiotics.
Metallo-beta-lactamase-Producing Gram-Negative Bacilli: Laboratory-Based Surveillance in Cooperation with 13 Clinical Laboratories in the Kinki Region of Japan.
The study identified metallo-beta-lactamase (MBL) genes, including blaIMP-1, blaIMP-2, and blaVIM-2, in various gram-negative bacilli, highlighting the widespread distribution of MBL-producing organisms in the Kinki region of Japan.
Metallo-beta-lactamase-Producing Gram-Negative Bacilli: Laboratory-Based Surveillance in Cooperation with 13 Clinical Laboratories in the Kinki Region of Japan.
The study identified metallo-beta-lactamase (MBL) genes, including blaIMP-1, blaIMP-2, and blaVIM-2, in various gram-negative bacilli, highlighting the widespread distribution of MBL-producing organisms in the Kinki region of Japan.
Metallo-beta-lactamase-Producing Gram-Negative Bacilli: Laboratory-Based Surveillance in Cooperation with 13 Clinical Laboratories in the Kinki Region of Japan.
The study identified metallo-beta-lactamase (MBL) genes, including blaIMP-1, blaIMP-2, and blaVIM-2, in various gram-negative bacilli, highlighting the widespread distribution of MBL-producing organisms in the Kinki region of Japan.
Integron Carrying a Novel Metallo-β-Lactamase Gene, blaIMP-16, and a Fused Form of Aminoglycoside-Resistant Gene aac(6′)-30/aac(6′)-Ib′: report from the SENTRY Antimicrobial Surveillance Program.
The study identifies a novel metallo-beta-lactamase gene, blaIMP-16, and a fused form of aminoglycoside-resistant gene aac(6′)-30/aac(6′)-Ib′ in a Pseudomonas aeruginosa strain. blaIMP-16 confers resistance to carbapenems and cephalosporins, while the fused aac(6′)-30/aac(6′)-Ib′ gene confers resistance to multiple aminoglycosides.
Integron carrying a novel metallo-beta-lactamase gene, blaIMP-16, and a fused form of aminoglycoside-resistant gene aac(6')-30/aac(6')-Ib': report from the SENTRY Antimicrobial Surveillance Program.
Integron carrying a novel metallo-beta-lactamase gene, blaIMP-16, and a fused form of aminoglycoside-resistant gene aac(6')-30/aac(6')-Ib': report from the SENTRY Antimicrobial Surveillance Program.
Integron carrying a novel metallo-beta-lactamase gene, blaIMP-16, and a fused form of aminoglycoside-resistant gene aac(6')-30/aac(6')-Ib': report from the SENTRY Antimicrobial Surveillance Program.
Integron carrying a novel metallo-beta-lactamase gene, blaIMP-16, and a fused form of aminoglycoside-resistant gene aac(6')-30/aac(6')-Ib': report from the SENTRY Antimicrobial Surveillance Program.
First isolation of metallo-beta-lactamase-producing multiresistant Klebsiella pneumoniae from a patient in Brazil.
The study reports the first detection of a metallo-β-lactamase (IMP-1)-producing K. pneumoniae clinical strain in Latin America, highlighting the emergence of carbapenem resistance in this region.
Impact of remote mutations on metallo-beta-lactamase substrate specificity: implications for the evolution of antibiotic resistance.
The study identifies several point mutations in metallo-beta-lactamases (IMP-1 and IMP-6) that alter substrate specificity and enhance resistance to β-lactam antibiotics, particularly type I substrates like ceftazidime, benzylpenicillin, ampicillin, and imipenem.
Impact of remote mutations on metallo-beta-lactamase substrate specificity: implications for the evolution of antibiotic resistance.
The study identifies several point mutations in metallo-beta-lactamases (IMP-1 and IMP-6) that alter substrate specificity and enhance resistance to β-lactam antibiotics, particularly type I substrates like ceftazidime, benzylpenicillin, ampicillin, and imipenem.
Metallo-beta-lactamases: the quiet before the storm?
The paper characterizes various metallo-beta-lactamase genes (blaIMP and blaVIM) and their roles in conferring resistance to carbapenems in multiple bacterial species.
Metallo-beta-lactamases: the quiet before the storm?
The paper characterizes various metallo-beta-lactamase genes (blaIMP and blaVIM) and their roles in conferring resistance to carbapenems in multiple bacterial species.
Metallo-beta-lactamases: the quiet before the storm?
The paper characterizes various metallo-beta-lactamase genes (blaIMP and blaVIM) and their roles in conferring resistance to carbapenems in multiple bacterial species.
Metallo-beta-lactamases: the quiet before the storm?
The paper characterizes various metallo-beta-lactamase genes (blaIMP and blaVIM) and their roles in conferring resistance to carbapenems in multiple bacterial species.
Metallo-beta-lactamases: the quiet before the storm?
The paper characterizes various metallo-beta-lactamase genes (blaIMP and blaVIM) and their roles in conferring resistance to carbapenems in multiple bacterial species.
Detection of Pseudomonas aeruginosa producing metallo-beta-lactamases in a large centralized laboratory.
The study identifies bla VIM and bla IMP genes as the primary metallo-beta-lactamase genes responsible for carbapenem resistance in Pseudomonas aeruginosa isolates.
Nosocomial outbreak caused by multidrug-resistant Pseudomonas aeruginosa producing IMP-13 metallo-beta-lactamase.
The study describes a nosocomial outbreak caused by multidrug-resistant Pseudomonas aeruginosa producing the IMP-13 metallo-beta-lactamase, which conferred resistance to carbapenems, extended-spectrum cephalosporins, aminoglycosides, and fluoroquinolones.
Sensitive EDTA-Based Microbiological Assays for Detection of Metallo-β-Lactamases in Nonfermentative Gram-Negative Bacteria.
The study describes the development of a sensitive microbiological assay (EIM) for detecting metallo-β-lactamases (MBLs) in nonfermentative gram-negative bacteria. It identifies several MBL genes, including bla VIM-11a, bla IMP-7, bla SPM-1, bla L1-like, bla GOB-like, bla IND-like, and bla BcII, which confer resistance to carbapenems.
bla(IMP-9) and its association with large plasmids carried by Pseudomonas aeruginosa isolates from the People's Republic of China.
bla(IMP-9) and its association with large plasmids carried by Pseudomonas aeruginosa isolates from the People's Republic of China.
bla(IMP-9) and its association with large plasmids carried by Pseudomonas aeruginosa isolates from the People's Republic of China.
bla(IMP-9) and its association with large plasmids carried by Pseudomonas aeruginosa isolates from the People's Republic of China.
First occurrence of a Pseudomonas aeruginosa isolate in the United States producing an IMP metallo-beta-lactamase, IMP-18.
The study reports the first occurrence of a Pseudomonas aeruginosa isolate in the United States producing the IMP-18 metallo-beta-lactamase, which confers resistance to carbapenems.
First occurrence of a Pseudomonas aeruginosa isolate in the United States producing an IMP metallo-beta-lactamase, IMP-18.
First occurrence of a Pseudomonas aeruginosa isolate in the United States producing an IMP metallo-beta-lactamase, IMP-18.
First occurrence of a Pseudomonas aeruginosa isolate in the United States producing an IMP metallo-beta-lactamase, IMP-18.
First occurrence of a Pseudomonas aeruginosa isolate in the United States producing an IMP metallo-beta-lactamase, IMP-18.
Phenotypic detection of carbapenem-susceptible metallo-beta-lactamase-producing gram-negative bacilli in the clinical laboratory.
Phenotypic detection of carbapenem-susceptible metallo-beta-lactamase-producing gram-negative bacilli in the clinical laboratory.
Molecular Epidemiology of Metallo-beta-lactamase-Producing Pseudomonas aeruginosa in the Calgary Health Region: Emergence of VIM-2-Producing Isolates.
The study identifies VIM-2 and IMP-7 metallo-beta-lactamase genes along with aacC1, aacA4, and aacC4 gene cassettes in Pseudomonas aeruginosa isolates, highlighting the molecular epidemiology of carbapenem-resistant strains in the Calgary Health Region.
First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France.
The study reports the first occurrence of the IMP-19 metallo-beta-lactamase in Aeromonas caviae, which differs from IMP-2 by a single amino acid change (Arg to Ala at position 38).
First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France.
Successive emergence of extended-spectrum beta-lactamase-producing and carbapenemase-producing Enterobacter aerogenes isolates in a university hospital.
The study identifies bla TEM-24, bla SHV-12, bla IMP-1, and bla VIM-2 as the primary resistance genes in carbapenem-resistant Enterobacter aerogenes isolates, highlighting the role of beta-lactamases in resistance to various antibiotics.
IMP-15-producing Pseudomonas aeruginosa strain isolated in a U.S. medical center: a recent arrival from Mexico.
The study identifies the IMP-15 metallo-beta-lactamase in a Pseudomonas aeruginosa strain isolated in the U.S., suggesting its origin in Mexico. The gene was found in a class 1 integron along with other resistance genes.
IMP-15-producing Pseudomonas aeruginosa strain isolated in a U.S. medical center: a recent arrival from Mexico.
IMP-15-producing Pseudomonas aeruginosa strain isolated in a U.S. medical center: a recent arrival from Mexico.
IMP-15-producing Pseudomonas aeruginosa strain isolated in a U.S. medical center: a recent arrival from Mexico.
IMP-15-producing Pseudomonas aeruginosa strain isolated in a U.S. medical center: a recent arrival from Mexico.
Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experience.
The study identifies multiple beta-lactamase genes, including bla CMY-2, bla DHA, bla TEM, bla CTX-M, bla IMP-4, and bla KPC-2, contributing to broad-spectrum beta-lactam resistance in Enterobacteriaceae isolates from a children's hospital.
Molecular characterisation of the metallo-beta-lactamase genes in imipenem-resistant Gram-negative bacteria from a university hospital in southern Taiwan.
Molecular characterisation of the metallo-beta-lactamase genes in imipenem-resistant Gram-negative bacteria from a university hospital in southern Taiwan.
Molecular characterisation of the metallo-beta-lactamase genes in imipenem-resistant Gram-negative bacteria from a university hospital in southern Taiwan.
Molecular characterisation of the metallo-beta-lactamase genes in imipenem-resistant Gram-negative bacteria from a university hospital in southern Taiwan.
First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy.
The study identified the presence of acquired metallo-beta-lactamases (MBLs) in gram-negative pathogens in Italy, including blaIMP-13, blaVIM-1, and blaVIM-2 genes. These genes conferred resistance to carbapenems, cephalosporins, fluoroquinolones, and gentamicin in Pseudomonas aeruginosa, Pseudomonas putida, and Enterobacter cloacae.
Evaluation of phenotypic tests for detection of metallo-beta-lactamase-producing Pseudomonas aeruginosa strains in China.
The study identified and characterized bla VIM-2, bla IMP-9, and bla IMP-1 genes in metallo-beta-lactamase-producing Pseudomonas aeruginosa strains in China.
Evaluation of phenotypic tests for detection of metallo-beta-lactamase-producing Pseudomonas aeruginosa strains in China.
The study identified and characterized bla VIM-2, bla IMP-9, and bla IMP-1 genes in metallo-beta-lactamase-producing Pseudomonas aeruginosa strains in China.
Identification of bla(IMP-22) in Pseudomonas spp. in urban wastewater and nosocomial environments: biochemical characterization of a new IMP metallo-enzyme variant and its genetic location.
Identification of bla(IMP-22) in Pseudomonas spp. in urban wastewater and nosocomial environments: biochemical characterization of a new IMP metallo-enzyme variant and its genetic location.
Identification of bla(IMP-22) in Pseudomonas spp. in urban wastewater and nosocomial environments: biochemical characterization of a new IMP metallo-enzyme variant and its genetic location.
Identification of bla(IMP-22) in Pseudomonas spp. in urban wastewater and nosocomial environments: biochemical characterization of a new IMP metallo-enzyme variant and its genetic location.
Immediate appearance of plasmid-mediated resistance to multiple antibiotics upon antibiotic selection: an argument for systematic resistance epidemiology.
A plasmid carrying the blaIMP-4 gene rapidly emerged in an E. coli strain following antibiotic exposure, demonstrating the swift acquisition of multidrug resistance via plasmid transfer.
Detection of plasmid-mediated IMP-1 metallo-beta-lactamase and quinolone resistance determinants in an ertapenem-resistant Enterobacter cloacae isolate.
The study identified the plasmid-mediated IMP-1 metallo-beta-lactamase and quinolone resistance determinant qnrS1 in an ertapenem-resistant Enterobacter cloacae isolate. Additionally, mutations in the gyrA and parC genes were found to contribute to quinolone resistance.
Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion.
The study identifies blaVIM-2, blaVIM-4, and blaIMP-14 as metallo-beta-lactamase genes contributing to carbapenem resistance in Pseudomonas aeruginosa isolates from Norway and Sweden.
Updated functional classification of beta-lactamases.
The paper updates the functional classification of beta-lactamases, detailing their substrate preferences, inhibitor profiles, and clinical relevance. It highlights the diversity and evolution of these enzymes, emphasizing their role in antibiotic resistance.
Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan.
The study identified various beta-lactamase genes, including bla IMP-1, bla IMP-8, bla OXA-58, bla VEB-3, and bla ADC, which confer resistance to beta-lactam antibiotics in Acinetobacter genospecies 3 isolates in Taiwan.
Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan.
The study identified various beta-lactamase genes, including bla IMP-1, bla IMP-8, bla OXA-58, bla VEB-3, and bla ADC, which confer resistance to beta-lactam antibiotics in Acinetobacter genospecies 3 isolates in Taiwan.
Multilocus sequence types of carbapenem-resistant Pseudomonas aeruginosa in Singapore carrying metallo-beta-lactamase genes, including the novel bla(IMP-26) gene.
Multilocus sequence types of carbapenem-resistant Pseudomonas aeruginosa in Singapore carrying metallo-beta-lactamase genes, including the novel bla(IMP-26) gene.
Multilocus sequence types of carbapenem-resistant Pseudomonas aeruginosa in Singapore carrying metallo-beta-lactamase genes, including the novel bla(IMP-26) gene.
Efficacy of calcium-EDTA as an inhibitor for metallo-beta-lactamase in a mouse model of Pseudomonas aeruginosa pneumonia.
The study demonstrates that calcium-EDTA effectively inhibits metallo-beta-lactamases (MBLs) in Pseudomonas aeruginosa, reducing the minimum inhibitory concentrations (MICs) of imipenem in MBL-producing strains. This suggests that calcium-EDTA could enhance the efficacy of β-lactam antibiotics against MBL-producing pathogens.
Efficacy of calcium-EDTA as an inhibitor for metallo-beta-lactamase in a mouse model of Pseudomonas aeruginosa pneumonia.
The study demonstrates that calcium-EDTA effectively inhibits metallo-beta-lactamases (MBLs) in Pseudomonas aeruginosa, reducing the minimum inhibitory concentrations (MICs) of imipenem in MBL-producing strains. This suggests that calcium-EDTA could enhance the efficacy of β-lactam antibiotics against MBL-producing pathogens.
Efficacy of calcium-EDTA as an inhibitor for metallo-beta-lactamase in a mouse model of Pseudomonas aeruginosa pneumonia.
The study demonstrates that calcium-EDTA effectively inhibits metallo-beta-lactamases (MBLs) in Pseudomonas aeruginosa, reducing the minimum inhibitory concentrations (MICs) of imipenem in MBL-producing strains. This suggests that calcium-EDTA could enhance the efficacy of β-lactam antibiotics against MBL-producing pathogens.
Efficacy of calcium-EDTA as an inhibitor for metallo-beta-lactamase in a mouse model of Pseudomonas aeruginosa pneumonia.
The study demonstrates that calcium-EDTA effectively inhibits metallo-beta-lactamases (MBLs) in Pseudomonas aeruginosa, reducing the minimum inhibitory concentrations (MICs) of imipenem in MBL-producing strains. This suggests that calcium-EDTA could enhance the efficacy of β-lactam antibiotics against MBL-producing pathogens.
Intrahospital spread of carbapenem-resistant Pseudomonas aeruginosa in a University Hospital in Florianópolis, Santa Catarina, Brazil.
The study identified blaSPM-1 and blaIMP-16 genes as responsible for carbapenem resistance in Pseudomonas aeruginosa isolates, highlighting the role of clonal spread in the hospital setting.
First report of Klebsiella oxytoca strain coproducing KPC-2 and IMP-8 carbapenemases.
The study reports the first case of a Klebsiella oxytoca strain coproducing plasmid-mediated KPC-2 and IMP-8 carbapenemases, highlighting their role in high-level resistance to imipenem and ertapenem.
IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons.
IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons.
IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons.
IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons.
IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons.
IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons.
IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons.
IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons.
IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons.
IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons.
IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons.
IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons.
IMP-producing carbapenem-resistant Klebsiella pneumoniae in the United States.
The study identifies IMP-4, a metallo-beta-lactamase, as a novel mechanism of carbapenem resistance in Klebsiella pneumoniae in the United States.
Antimicrobial resistance determinants in imipenem-nonsusceptible Acinetobacter calcoaceticus-baumannii complex isolated in Daejeon, Korea.
The study identified various antimicrobial resistance genes including blaOXA-51-like, blaOXA-23, blaIMP-1, blaVIM-2, aac(6')-Ib, aph(3')-Ia, aph(3')-VI, and armA in imipenem-nonsusceptible Acinetobacter calcoaceticus-baumannii complex isolates. Additionally, mutations in gyrA and parC were found to confer fluoroquinolone resistance.
Molecular diversity in mechanisms of carbapenem resistance in paediatric Enterobacteriaceae.
The study identifies various carbapenem resistance mechanisms in pediatric Enterobacteriaceae, including plasmid-mediated beta-lactamases (CTX-M, CMY, KPC, IMP), chromosomal beta-lactamase (SME), and porin alterations (ompK35 and ompK36).
Effective antibiotics in combination against extreme drug-resistant Pseudomonas aeruginosa with decreased susceptibility to polymyxin B.
The study identifies metallo-beta-lactamase genes (blaIMP and blaVIM) and other resistance genes (VEB-1 and OXA-10) in XDR-PA isolates, highlighting the need for combination therapies against these resistant strains.
Detection of SPM and IMP metallo-beta-lactamases in clinical specimens of Pseudomonas aeruginosa from a Brazilian public tertiary hospital.
The study identified blaSPM and blaIMP genes encoding metallo-beta-lactamases in multidrug-resistant Pseudomonas aeruginosa isolates, contributing to carbapenem resistance.
Antimicrobial Resistance in Stenotrophomonas maltophilia: Mechanisms, Clinical Implications, and Potential Therapeutic Strategies
The paper discusses the multidrug-resistant nature of Stenotrophomonas maltophilia, highlighting its resistance to various antibiotics including β-lactams, fluoroquinolones, aminoglycosides, and polymyxins. It emphasizes the challenges in treating infections caused by this pathogen due to its intrinsic resistance mechanisms and the need for alternative therapeutic approaches.
Phenotypic Screening of Carbapenemases and Associated β-Lactamases in Carbapenem-Resistant Enterobacteriaceae.
The study identifies and characterizes various carbapenemases, including blaIMP, blaVIM, blaNDM-1, blaKPC, and blaOXA-48, in carbapenem-resistant Enterobacteriaceae through phenotypic testing with inhibitor-impregnated agar.
IMP-29, a novel IMP-type metallo-beta-lactamase in Pseudomonas aeruginosa.
The study identifies IMP-29, a novel IMP-type metallo-beta-lactamase in Pseudomonas aeruginosa, which efficiently hydrolyzes carbapenems.
IMP-29, a novel IMP-type metallo-β-lactamase in Pseudomonas aeruginosa.
IMP-29, a novel IMP-type metallo-β-lactamase in Pseudomonas aeruginosa.
IMP-29, a novel IMP-type metallo-β-lactamase in Pseudomonas aeruginosa.
IMP-29, a novel IMP-type metallo-β-lactamase in Pseudomonas aeruginosa.
Two novel class I integron arrays containing IMP-18 metallo-beta-lactamase gene in Pseudomonas aeruginosa clinical isolates from Puerto Rico.
The study identifies two novel class I integron arrays containing the IMP-18 metallo-beta-lactamase gene and a new variant, blaOXA-224, in Pseudomonas aeruginosa clinical isolates from Puerto Rico.
The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.
The paper discusses various virulence factors and mechanisms contributing to the pathogenicity and antibiotic resistance of Acinetobacter baumannii, including biofilm formation, surface polysaccharides, and outer membrane proteins.
Characterization of a novel IMP-28 metallo-beta-lactamase from a Spanish Klebsiella oxytoca clinical isolate.
The study characterizes a novel IMP-28 metallo-beta-lactamase from a Spanish Klebsiella oxytoca clinical isolate, demonstrating its lower hydrolytic capacity compared to IMP-1, primarily due to the His306Gln mutation affecting substrate accessibility and hydrolysis.
Characterization of a novel IMP-28 metallo-β-lactamase from a Spanish Klebsiella oxytoca clinical isolate.
Characterization of a novel IMP-28 metallo-β-lactamase from a Spanish Klebsiella oxytoca clinical isolate.
Characterization of a novel IMP-28 metallo-β-lactamase from a Spanish Klebsiella oxytoca clinical isolate.
Characterization of a novel IMP-28 metallo-β-lactamase from a Spanish Klebsiella oxytoca clinical isolate.
Current epidemiology and growing resistance of gram-negative pathogens.
The paper highlights the emergence and spread of multidrug-resistant Gram-negative pathogens, focusing on extended-spectrum beta-lactamases (ESBLs) such as CTX-M-15 and CTX-M-14, carbapenemases like KPC-2, VIM-2, and IMP-6, and aminoglycoside-modifying enzymes such as aac(6')-Ib-cr and armA. It emphasizes the global dissemination of these resistance mechanisms and their impact on treatment options.
Characterization of carbapenemase genes in Enterobacteriaceae species exhibiting decreased susceptibility to carbapenems in a university hospital in Chongqing, China.
The study identified four carbapenemase genes (blaIMP-8, blaOXA-1, blaIMP-26, and blaOXA-47) in 10 isolates of Enterobacteriaceae species with decreased susceptibility to carbapenems. blaIMP-8 and blaOXA-1 were the most prevalent.
Characterization of carbapenemase genes in Enterobacteriaceae species exhibiting decreased susceptibility to carbapenems in a university hospital in Chongqing, China.
The study identified four carbapenemase genes (blaIMP-8, blaOXA-1, blaIMP-26, and blaOXA-47) in 10 isolates of Enterobacteriaceae species with decreased susceptibility to carbapenems. blaIMP-8 and blaOXA-1 were the most prevalent.
Phenotypic detection of metallo-β-lactamase in imipenem-resistant Pseudomonas aeruginosa.
The study identifies and characterizes several metallo-beta-lactamase genes (blaIMP-4, blaIMP-7, blaVIM-2, and blaVIM-11) responsible for carbapenem resistance in imipenem-resistant Pseudomonas aeruginosa isolates.
Phenotypic detection of metallo-β-lactamase in imipenem-resistant Pseudomonas aeruginosa.
The study identifies and characterizes several metallo-beta-lactamase genes (blaIMP-4, blaIMP-7, blaVIM-2, and blaVIM-11) responsible for carbapenem resistance in imipenem-resistant Pseudomonas aeruginosa isolates.
Evaluation of double-disk potentiation and disk potentiation tests using dipicolinic acid for detection of metallo-beta-lactamase-producing pseudomonas spp. and Acinetobacter spp.
The study evaluates the effectiveness of dipicolinic acid (DPA) in detecting metallo-beta-lactamase (MBL)-producing Pseudomonas spp. and Acinetobacter spp., identifying blaIMP-6 and blaVIM-2 as significant resistance genes.
Natural transformation facilitates transfer of transposons, integrons and gene cassettes between bacterial species.
The study demonstrates that natural transformation facilitates the transfer of transposons, integrons, and gene cassettes between bacterial species, leading to the acquisition of antibiotic resistance traits. Specific resistance genes such as aadB, blaIMP-5, blaOXA-30, dfrA12, aadA2, and aacA4 were identified and characterized.
Mutagenesis of zinc ligand residue Cys221 reveals plasticity in the IMP-1 metallo-beta-lactamase active site.
The study identifies Cys221 as critical for IMP-1 metallo-beta-lactamase stability and function. Substitutions at position 221, particularly C221D and C221G, retain partial enzymatic activity and resistance to β-lactam antibiotics, highlighting the plasticity of the Zn2-binding site.
Metallo-β-lactamase-production in meropenem-susceptible Pseudomonas aeruginosa isolates: risk for silent spread.
The study characterizes two meropenem-susceptible Pseudomonas aeruginosa isolates that produce the metallo-β-lactamase IMP-16, highlighting the risk of silent spread of MBL-encoding genes.
The sequence-activity relationship between metallo-beta-lactamases IMP-1, IMP-6, and IMP-25 suggests an evolutionary adaptation to meropenem exposure.
The study characterizes the metallo-beta-lactamases IMP-1, IMP-6, and IMP-25, highlighting their roles in conferring resistance to various β-lactam antibiotics, particularly meropenem and doripenem. Mutations such as S262G and G235S were found to influence resistance profiles.
The sequence-activity relationship between metallo-beta-lactamases IMP-1, IMP-6, and IMP-25 suggests an evolutionary adaptation to meropenem exposure.
The study characterizes the metallo-beta-lactamases IMP-1, IMP-6, and IMP-25, highlighting their roles in conferring resistance to various β-lactam antibiotics, particularly meropenem and doripenem. Mutations such as S262G and G235S were found to influence resistance profiles.
The sequence-activity relationship between metallo-beta-lactamases IMP-1, IMP-6, and IMP-25 suggests an evolutionary adaptation to meropenem exposure.
The study characterizes the metallo-beta-lactamases IMP-1, IMP-6, and IMP-25, highlighting their roles in conferring resistance to various β-lactam antibiotics, particularly meropenem and doripenem. Mutations such as S262G and G235S were found to influence resistance profiles.
The sequence-activity relationship between metallo-β-lactamases IMP-1, IMP-6, and IMP-25 suggests an evolutionary adaptation to meropenem exposure.
The sequence-activity relationship between metallo-β-lactamases IMP-1, IMP-6, and IMP-25 suggests an evolutionary adaptation to meropenem exposure.
The sequence-activity relationship between metallo-β-lactamases IMP-1, IMP-6, and IMP-25 suggests an evolutionary adaptation to meropenem exposure.
The sequence-activity relationship between metallo-β-lactamases IMP-1, IMP-6, and IMP-25 suggests an evolutionary adaptation to meropenem exposure.
Spread of the bla(IMP-13) gene in French Pseudomonas aeruginosa through sequence types ST621, ST308 and ST111.
Spread of the bla(IMP-13) gene in French Pseudomonas aeruginosa through sequence types ST621, ST308 and ST111.
Spread of the bla(IMP-13) gene in French Pseudomonas aeruginosa through sequence types ST621, ST308 and ST111.
Spread of the bla(IMP-13) gene in French Pseudomonas aeruginosa through sequence types ST621, ST308 and ST111.
Tracking down antibiotic-resistant Pseudomonas aeruginosa isolates in a wastewater network.
The study identified the ESBL PER-1 and the MBL IMP-29 in Pseudomonas aeruginosa isolates from hospital wastewater and treated water within the WWTP.
Detection of a phylogenetically distinct IMP-type metallo-β-lactamase, IMP-35, in a CC235 Pseudomonas aeruginosa from the Dutch-German border region (Euregio).
Detection of a phylogenetically distinct IMP-type metallo-β-lactamase, IMP-35, in a CC235 Pseudomonas aeruginosa from the Dutch-German border region (Euregio).
Detection of a phylogenetically distinct IMP-type metallo-β-lactamase, IMP-35, in a CC235 Pseudomonas aeruginosa from the Dutch-German border region (Euregio).
Detection of a phylogenetically distinct IMP-type metallo-β-lactamase, IMP-35, in a CC235 Pseudomonas aeruginosa from the Dutch-German border region (Euregio).
Faecal carriage of oxyiminocephalosporin-resistant Enterobacteriaceae among paediatric units in different hospitals in the south of France.
The study identified the presence of oxyiminocephalosporin-resistant Enterobacteriaceae, including CTX-M-15-producing E. coli and IMP-1-producing P. aeruginosa, highlighting the widespread dissemination of multidrug-resistant bacteria in pediatric populations in southern France.
Detection of IMP Metallo-beta-lactamase in Carbapenem-Nonsusceptible Enterobacteriaceae and Non-Glucose-Fermenting Gram-Negative Rods by Immunochromatography Assay.
The study evaluated an immunochromatography assay for detecting IMP metallo-beta-lactamase in carbapenem-nonsusceptible bacteria, identifying three new IMP variants (IMP-40, IMP-41, and IMP-42).
Detection of IMP metallo-β-lactamase in carbapenem-nonsusceptible Enterobacteriaceae and non-glucose-fermenting Gram-negative rods by immunochromatography assay.
Detection of IMP metallo-β-lactamase in carbapenem-nonsusceptible Enterobacteriaceae and non-glucose-fermenting Gram-negative rods by immunochromatography assay.
Detection of IMP metallo-β-lactamase in carbapenem-nonsusceptible Enterobacteriaceae and non-glucose-fermenting Gram-negative rods by immunochromatography assay.
Detection of IMP metallo-β-lactamase in carbapenem-nonsusceptible Enterobacteriaceae and non-glucose-fermenting Gram-negative rods by immunochromatography assay.
Detection of IMP metallo-β-lactamase in carbapenem-nonsusceptible Enterobacteriaceae and non-glucose-fermenting Gram-negative rods by immunochromatography assay.
Detection of IMP metallo-β-lactamase in carbapenem-nonsusceptible Enterobacteriaceae and non-glucose-fermenting Gram-negative rods by immunochromatography assay.
Detection of IMP metallo-β-lactamase in carbapenem-nonsusceptible Enterobacteriaceae and non-glucose-fermenting Gram-negative rods by immunochromatography assay.
Detection of IMP metallo-β-lactamase in carbapenem-nonsusceptible Enterobacteriaceae and non-glucose-fermenting Gram-negative rods by immunochromatography assay.
Detection of IMP metallo-β-lactamase in carbapenem-nonsusceptible Enterobacteriaceae and non-glucose-fermenting Gram-negative rods by immunochromatography assay.
A novel metallo-β-lactamase, IMP-34, in Klebsiella isolates with decreased resistance to imipenem.
A novel metallo-β-lactamase, IMP-34, in Klebsiella isolates with decreased resistance to imipenem.
A novel metallo-β-lactamase, IMP-34, in Klebsiella isolates with decreased resistance to imipenem.
A novel metallo-β-lactamase, IMP-34, in Klebsiella isolates with decreased resistance to imipenem.
Detection of bla(IMP) and bla(VIM) metallo-beta-lactamases genes among Pseudomonas aeruginosa strains.
The study identified blaIMP-1 genes in Pseudomonas aeruginosa strains, indicating resistance to multiple beta-lactam antibiotics.
Complete sequence of pOZ176, a 500-kilobase IncP-2 plasmid encoding IMP-9-mediated carbapenem resistance, from outbreak isolate Pseudomonas aeruginosa 96.
The study characterizes the blaIMP-9 gene, which is responsible for carbapenem resistance in the Pseudomonas aeruginosa 96 isolate, and identifies it as part of the IncP-2 plasmid pOZ176.
Identification and characterization of metallo-β-lactamases producing Pseudomonas aeruginosa clinical isolates in University Hospital from Zanjan Province, Iran.
The study identified blaIMP and blaVIM genes in Pseudomonas aeruginosa isolates from Zanjan Province, Iran, highlighting their role in imipenem resistance.
IMP-43 and IMP-44 metallo-beta-lactamases with increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa.
The study identifies two novel IMP-type metallo-beta-lactamases, IMP-43 and IMP-44, which exhibit increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa isolates. IMP-43 has a Val67Phe substitution compared to IMP-7, while IMP-44 has Val67Phe and Phe87Ser substitutions compared to IMP-11. Both enzymes show enhanced catalytic efficiency against carbapenems.
IMP-43 and IMP-44 metallo-beta-lactamases with increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa.
The study identifies two novel IMP-type metallo-beta-lactamases, IMP-43 and IMP-44, which exhibit increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa isolates. IMP-43 has a Val67Phe substitution compared to IMP-7, while IMP-44 has Val67Phe and Phe87Ser substitutions compared to IMP-11. Both enzymes show enhanced catalytic efficiency against carbapenems.
IMP-43 and IMP-44 metallo-β-lactamases with increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa.
IMP-43 and IMP-44 metallo-β-lactamases with increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa.
IMP-43 and IMP-44 metallo-β-lactamases with increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa.
IMP-43 and IMP-44 metallo-β-lactamases with increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa.
IMP-43 and IMP-44 metallo-β-lactamases with increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa.
IMP-43 and IMP-44 metallo-β-lactamases with increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa.
IMP-43 and IMP-44 metallo-β-lactamases with increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa.
IMP-43 and IMP-44 metallo-β-lactamases with increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa.
Biochemical characterization of IMP-30, a metallo-beta-lactamase with enhanced activity toward ceftazidime.
IMP-30, a metallo-beta-lactamase with a single E59K mutation, shows enhanced activity towards ceftazidime compared to IMP-1, leading to increased resistance.
Biochemical characterization of IMP-30, a metallo-β-lactamase with enhanced activity toward ceftazidime.
Biochemical characterization of IMP-30, a metallo-β-lactamase with enhanced activity toward ceftazidime.
Biochemical characterization of IMP-30, a metallo-β-lactamase with enhanced activity toward ceftazidime.
Biochemical characterization of IMP-30, a metallo-β-lactamase with enhanced activity toward ceftazidime.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
The first case of septicemia caused by imipenem-susceptible, meropenem-resistant Klebsiella pneumoniae.
The study reports the first case of septicemia caused by imipenem-susceptible, meropenem-resistant Klebsiella pneumoniae (ISMRK), which carries the blaIMP-6 and blaCTX-M-2 genes, responsible for resistance to most beta-lactams except imipenem.
Isolation of the first IMP-4 metallo-β-lactamase producing Klebsiella pneumoniae in Tianjin, China.
The study identifies the first IMP-4 metallo-β-lactamase producing Klebsiella pneumoniae isolate in Tianjin, China, highlighting the role of blaIMP-4 in carbapenem resistance.
IMP-33, a New IMP Variant Detected in Pseudomonas aeruginosa from Sicily.
The study identifies a novel IMP variant, IMP-33, in Pseudomonas aeruginosa from Sicily, which exhibits resistance to carbapenems.
IMP-33, a New IMP variant detected in Pseudomonas aeruginosa from Sicily.
IMP-33, a New IMP variant detected in Pseudomonas aeruginosa from Sicily.
IMP-33, a New IMP variant detected in Pseudomonas aeruginosa from Sicily.
IMP-33, a New IMP variant detected in Pseudomonas aeruginosa from Sicily.
First Report of bla(IMP-8) in Raoultella planticola.
The study reports the first occurrence of the bla(IMP-8) gene in Raoultella planticola, highlighting its role in carbapenem resistance.
Types and prevalence of carbapenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex in Northern Taiwan.
The study identifies the prevalence of carbapenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex in Northern Taiwan, highlighting the presence of blaOXA-24-like, blaOXA-51-like, blaOXA-23-like, and IMP-1 genes as major contributors to carbapenem resistance.
Effect of metallo-β-lactamase production and multidrug resistance on clinical outcomes in patients with Pseudomonas aeruginosa bloodstream infection: a retrospective cohort study.
The study identified VIM-2 and IMP-8 metallo-beta-lactamase genes in Pseudomonas aeruginosa isolates, which conferred resistance to carbapenems.
Updated molecular epidemiology of carbapenem-non-susceptible Escherichia coli in Taiwan: first identification of KPC-2 or NDM-1-producing E. coli in Taiwan.
The study identifies the first occurrence of KPC-2 and NDM-1 producing E. coli in Taiwan, highlighting the emergence of these carbapenemases as significant contributors to carbapenem resistance. The main resistance mechanism involves plasmidic AmpC β-lactamases (CMY-2 and DHA-1) in combination with loss of outer membrane porins OmpC and OmpF.
Multi-centre evaluation of real-time multiplex PCR for detection of carbapenemase genes OXA-48, VIM, IMP, NDM and KPC.
The study presents a real-time multiplex PCR assay for detecting the most prevalent carbapenemase genes, including blaOXA-48, blaVIM, blaIMP, blaNDM, and blaKPC, demonstrating high sensitivity and specificity.
Evaluation of phenotypic detection methods for metallo-β-lactamases (MBLs) in clinical isolates of Pseudomonas aeruginosa.
The study evaluated phenotypic detection methods for metallo-beta-lactamases (MBLs) in Pseudomonas aeruginosa clinical isolates, identifying blaIMP and blaVIM genes as the primary MBL producers.
Phenotypic and Genetic Characterization of Carbapenemase and ESBLs Producing Gram-negative Bacteria (GNB) Isolated from Patients with Cystic Fibrosis (CF) in Tehran Hospitals.
The study identified the presence of ESBLs and carbapenemase genes, including blaCTX-M, blaIMP-1, blaVIM-1, and blaVIM-2, in Gram-negative bacteria isolated from cystic fibrosis patients in Tehran hospitals.
Evaluation of an automated rapid diagnostic assay for detection of Gram-negative bacteria and their drug-resistance genes in positive blood cultures.
The study evaluated the Verigene BC-GN assay for rapid detection of Gram-negative bacteria and their drug-resistance genes in positive blood cultures. It successfully detected 9 bacterial species and 9 drug resistance genes, including bla CTX-M, bla IMP, bla KPC, bla NDM, bla OXA-23, bla OXA-24/40, bla OXA-48, bla OXA-58, and bla VIM.
Antimicrobial resistance pattern and their beta-lactamase encoding genes among Pseudomonas aeruginosa strains isolated from cancer patients.
The study identified blaVIM-2, blaOXA-10, blaVEB-1, blaNDM, and blaIMP-1 as the most prevalent beta-lactamase genes in P. aeruginosa isolates from Egypt, contributing to resistance against imipenem and ceftazidime.
Molecular and epidemiological characterization of IMP-type metallo-β-lactamase-producing Enterobacter cloacae in a Large tertiary care hospital in Japan.
The study identifies blaIMP as a gene conferring resistance to carbapenems in IMP-type metallo-beta-lactamase-producing Enterobacter cloacae.
CarbAcineto NP test for rapid detection of carbapenemase-producing Acinetobacter spp.
The study introduces the CarbAcineto NP test, a modified version of the Carba NP test, for the rapid and accurate detection of carbapenemase-producing Acinetobacter spp. The test successfully identifies various carbapenemases including OXA-23, OXA-24/OXA-40, OXA-58, OXA-143, GES-11, GES-14, NDM-1, NDM-2, IMP-1, IMP-4, VIM-4, and SIM-1.
CarbAcineto NP test for rapid detection of carbapenemase-producing Acinetobacter spp.
The study introduces the CarbAcineto NP test, a modified version of the Carba NP test, for the rapid and accurate detection of carbapenemase-producing Acinetobacter spp. The test successfully identifies various carbapenemases including OXA-23, OXA-24/OXA-40, OXA-58, OXA-143, GES-11, GES-14, NDM-1, NDM-2, IMP-1, IMP-4, VIM-4, and SIM-1.
Outbreak of Achromobacter xylosoxidans in an Italian Cystic fibrosis center: genome variability, biofilm production, antibiotic resistance, and motility in isolated strains.
The study identified the presence of the carbapenemase gene bla IMP-1 in some Achromobacter xylosoxidans strains, indicating resistance to carbapenems. Additionally, the study found high rates of resistance to various antibiotics including aztreonam, gentamicin, amikacin, tobramycin, cefepime, and ciprofloxacin.
IMP-45-producing multidrug-resistant Pseudomonas aeruginosa of canine origin.
IMP-45-producing multidrug-resistant Pseudomonas aeruginosa of canine origin.
IMP-45-producing multidrug-resistant Pseudomonas aeruginosa of canine origin.
IMP-45-producing multidrug-resistant Pseudomonas aeruginosa of canine origin.
Use of imipenem to detect KPC, NDM, OXA, IMP, and VIM carbapenemase activity from gram-negative rods in 75 minutes using liquid chromatography-tandem mass spectrometry.
The study developed an LC-MS/MS assay to detect carbapenemase activity from gram-negative rods, demonstrating that imipenem showed high sensitivity and specificity for detecting KPC, NDM, OXA, IMP, and VIM carbapenemases.
Evaluation of Zataria MultiFlora Boiss and Carum copticum antibacterial activity on IMP-type metallo-beta-lactamase-producing Pseudomonas aeruginosa.
The study identified the blaIMP-1 gene as the primary metallo-beta-lactamase gene responsible for carbapenem resistance in IMP-producing Pseudomonas aeruginosa strains isolated from burn patients.
Interspecies transfer of blaIMP-4 in a patient with prolonged colonization by IMP-4-producing Enterobacteriaceae.
The study reports the first case of prolonged colonization with in vivo interspecies transfer of the blaIMP-4 gene from Enterobacter cloacae to Escherichia coli, demonstrating the potential for horizontal plasmid transfer of carbapenem resistance.
Rapid identification of carbapenemase genes in gram-negative bacteria with an oligonucleotide microarray-based assay.
The study presents a microarray-based assay for the rapid identification of carbapenemase genes in Gram-negative bacteria, including bla KPC, bla VIM, bla NDM, bla GIM, bla OXA-23, bla OXA-48-group, bla OXA-51, bla OXA-58, and various beta-lactamase genes such as bla OXA-1, bla OXA-2, bla OXA-7, bla OXA-9, bla OXA-10, bla CTX-M1, and bla CTX-M15.
Rapid identification of carbapenemase genes in gram-negative bacteria with an oligonucleotide microarray-based assay.
The study presents a microarray-based assay for the rapid identification of carbapenemase genes in Gram-negative bacteria, including bla KPC, bla VIM, bla NDM, bla GIM, bla OXA-23, bla OXA-48-group, bla OXA-51, bla OXA-58, and various beta-lactamase genes such as bla OXA-1, bla OXA-2, bla OXA-7, bla OXA-9, bla OXA-10, bla CTX-M1, and bla CTX-M15.
Rapid identification of carbapenemase genes in gram-negative bacteria with an oligonucleotide microarray-based assay.
The study presents a microarray-based assay for the rapid identification of carbapenemase genes in Gram-negative bacteria, including bla KPC, bla VIM, bla NDM, bla GIM, bla OXA-23, bla OXA-48-group, bla OXA-51, bla OXA-58, and various beta-lactamase genes such as bla OXA-1, bla OXA-2, bla OXA-7, bla OXA-9, bla OXA-10, bla CTX-M1, and bla CTX-M15.
Rapid identification of carbapenemase genes in gram-negative bacteria with an oligonucleotide microarray-based assay.
The study presents a microarray-based assay for the rapid identification of carbapenemase genes in Gram-negative bacteria, including bla KPC, bla VIM, bla NDM, bla GIM, bla OXA-23, bla OXA-48-group, bla OXA-51, bla OXA-58, and various beta-lactamase genes such as bla OXA-1, bla OXA-2, bla OXA-7, bla OXA-9, bla OXA-10, bla CTX-M1, and bla CTX-M15.
Rapid identification of carbapenemase genes in gram-negative bacteria with an oligonucleotide microarray-based assay.
The study presents a microarray-based assay for the rapid identification of carbapenemase genes in Gram-negative bacteria, including bla KPC, bla VIM, bla NDM, bla GIM, bla OXA-23, bla OXA-48-group, bla OXA-51, bla OXA-58, and various beta-lactamase genes such as bla OXA-1, bla OXA-2, bla OXA-7, bla OXA-9, bla OXA-10, bla CTX-M1, and bla CTX-M15.
Rapid identification of carbapenemase genes in gram-negative bacteria with an oligonucleotide microarray-based assay.
The study presents a microarray-based assay for the rapid identification of carbapenemase genes in Gram-negative bacteria, including bla KPC, bla VIM, bla NDM, bla GIM, bla OXA-23, bla OXA-48-group, bla OXA-51, bla OXA-58, and various beta-lactamase genes such as bla OXA-1, bla OXA-2, bla OXA-7, bla OXA-9, bla OXA-10, bla CTX-M1, and bla CTX-M15.
Rapid identification of carbapenemase genes in gram-negative bacteria with an oligonucleotide microarray-based assay.
The study presents a microarray-based assay for the rapid identification of carbapenemase genes in Gram-negative bacteria, including bla KPC, bla VIM, bla NDM, bla GIM, bla OXA-23, bla OXA-48-group, bla OXA-51, bla OXA-58, and various beta-lactamase genes such as bla OXA-1, bla OXA-2, bla OXA-7, bla OXA-9, bla OXA-10, bla CTX-M1, and bla CTX-M15.
Rapid identification of carbapenemase genes in gram-negative bacteria with an oligonucleotide microarray-based assay.
The study presents a microarray-based assay for the rapid identification of carbapenemase genes in Gram-negative bacteria, including bla KPC, bla VIM, bla NDM, bla GIM, bla OXA-23, bla OXA-48-group, bla OXA-51, bla OXA-58, and various beta-lactamase genes such as bla OXA-1, bla OXA-2, bla OXA-7, bla OXA-9, bla OXA-10, bla CTX-M1, and bla CTX-M15.
Rapid identification of carbapenemase genes in gram-negative bacteria with an oligonucleotide microarray-based assay.
The study presents a microarray-based assay for the rapid identification of carbapenemase genes in Gram-negative bacteria, including bla KPC, bla VIM, bla NDM, bla GIM, bla OXA-23, bla OXA-48-group, bla OXA-51, bla OXA-58, and various beta-lactamase genes such as bla OXA-1, bla OXA-2, bla OXA-7, bla OXA-9, bla OXA-10, bla CTX-M1, and bla CTX-M15.
Spread of carbapenemase-producing enterobacteria in a southwest hospital in China.
The study identified IMP-4 and KPC-2 as carbapenemase genes responsible for carbapenem resistance in Enterobacteriaceae isolates from a hospital in China.
Co-existence of beta-lactamases in clinical isolates of Escherichia coli from Kathmandu, Nepal.
The study reports the high prevalence of bla CTX-M-type ESBL and co-existence of ESBLs and carbapenemases in E. coli isolates from Kathmandu, Nepal. It identifies multiple beta-lactamase genes including bla CTX-M, bla SHV, bla TEM, bla VIM, bla IMP, and bla NDM-1.
Multiple drug resistant carbapenemases producing Acinetobacter baumannii isolates harbours multiple R-plasmids.
The study identified the presence of multiple R-plasmids carrying carbapenemase genes such as blaOXA-51, blaOXA-23, and blaIMP-1 in multidrug-resistant Acinetobacter baumannii isolates.
Characterization by phenotypic and genotypic methods of metallo-β‑lactamase‑producing Pseudomonas aeruginosa isolated from patients with cystic fibrosis.
The study identified blaVIM and blaIMP genes in Pseudomonas aeruginosa isolates from cystic fibrosis patients, which confer resistance to carbapenems and cephalosporins.
Rapid Diagnostic Approaches for Antimicrobial Resistance
The paper discusses various rapid antimicrobial resistance testing methods, including molecular techniques like qPCR, DNA microarrays, Luminex xMAP, and next-generation sequencing (NGS), highlighting their roles in detecting resistance genes such as blaCTX-M, blaTEM, blaSHV, blaKPC, blaNDM, blaOXA-48, blaVIM, blaIMP, mecA, mecC, vanA, vanB, aacA-aphD, tetK, tetM, ermA, ermC, vatA, vatB, and vatC in different bacterial species.
Emergence of Citrobacter freundii carrying IMP-8 metallo-β-lactamase in Germany.
The study reports the first case of Citrobacter freundii carrying the IMP-8 metallo-beta-lactamase in Germany, highlighting the potential for spread of this resistance gene among enterobacterial species.
A case of IMP-4-, OXA-421-, OXA-96-, and CARB-2-producing Acinetobacter pittii sequence type 119 in Australia.
The study identifies a novel blaOXA-421 gene along with blaIMP-4, blaOXA-96, and blaCARB-2 in an Acinetobacter pittii strain, highlighting the presence of multiple carbapenemase genes contributing to carbapenem resistance.
IMP-1 encoded by a novel Tn402-like class 1 integron in clinical Achromobacter xylosoxidans, China.
The study identifies the blaIMP-1 gene encoding a carbapenemase in a novel Tn402-like class 1 integron within a conjugative IncP-1ß plasmid in Achromobacter xylosoxidans, which confers resistance to carbapenems.
Evaluation of tests to predict metallo-β-lactamase in cystic fibrosis (CF) and non-(CF) Pseudomonas.
The study evaluated phenotypic tests to predict the presence of metallo-β-lactamase (MBL) in Pseudomonas aeruginosa isolates, identifying blaSPM-1 and blaIMP-1 genes as responsible for carbapenem resistance.
Persistence and epidemic propagation of a Pseudomonas aeruginosa sequence type 235 clone harboring an IS26 composite transposon carrying the blaIMP-1 integron in Hiroshima, Japan, 2005 to 2012.
The study identifies the blaIMP-1 gene, a metallo-beta-lactamase gene, as a key factor in the persistence and epidemic propagation of a multidrug-resistant Pseudomonas aeruginosa clone in Hiroshima, Japan.
Carbapenem-nonsusceptible Enterobacteriaceae in Taiwan.
The study identified several carbapenemase genes, including blaKPC-2, blaIMP-8, blaNDM-1, and blaVIM-1, along with extended-spectrum beta-lactamase genes such as CTX-M, SHV, and ampC beta-lactamase genes like DHA and CMY, which contribute to carbapenem resistance in Enterobacteriaceae isolates in Taiwan.
Outbreak of multidrug resistant NDM-1-producing Klebsiella pneumoniae from a neonatal unit in Shandong Province, China.
The study identifies blaNDM-1, blaIMP-4, blaCTX-M-15, blaTEM-1, and blaDHA-1 as the major resistance genes in multidrug-resistant NDM-1-producing Klebsiella pneumoniae isolates from a neonatal unit in Shandong Province, China.
Description of IMP-31, a novel metallo-β-lactamase found in an ST235 Pseudomonas aeruginosa strain in Western Germany.
Description of IMP-31, a novel metallo-β-lactamase found in an ST235 Pseudomonas aeruginosa strain in Western Germany.
Description of IMP-31, a novel metallo-β-lactamase found in an ST235 Pseudomonas aeruginosa strain in Western Germany.
Description of IMP-31, a novel metallo-β-lactamase found in an ST235 Pseudomonas aeruginosa strain in Western Germany.
Characteristics of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in Korea.
The study identified blaIMP-6 and blaVIM-2 genes in 5.2% and 1.2% of carbapenem-non-susceptible P. aeruginosa isolates, respectively, indicating their role in carbapenem resistance in Korea.
Molecular analysis of the integrons of metallo-β-lactamase-producing Pseudomonas aeruginosa isolates collected by nationwide surveillance programs across Japan.
The study identifies various metallo-beta-lactamase (MBL) genes, including blaIMP-1, blaIMP-7, blaIMP-10, blaIMP-6, blaIMP-11, blaVIM-1, and a novel fosI gene cassette, in MBL-producing Pseudomonas aeruginosa isolates across Japan.
Molecular analysis of the integrons of metallo-β-lactamase-producing Pseudomonas aeruginosa isolates collected by nationwide surveillance programs across Japan.
The study identifies various metallo-beta-lactamase (MBL) genes, including blaIMP-1, blaIMP-7, blaIMP-10, blaIMP-6, blaIMP-11, blaVIM-1, and a novel fosI gene cassette, in MBL-producing Pseudomonas aeruginosa isolates across Japan.
Molecular analysis of the integrons of metallo-β-lactamase-producing Pseudomonas aeruginosa isolates collected by nationwide surveillance programs across Japan.
The study identifies various metallo-beta-lactamase (MBL) genes, including blaIMP-1, blaIMP-7, blaIMP-10, blaIMP-6, blaIMP-11, blaVIM-1, and a novel fosI gene cassette, in MBL-producing Pseudomonas aeruginosa isolates across Japan.
Molecular analysis of the integrons of metallo-β-lactamase-producing Pseudomonas aeruginosa isolates collected by nationwide surveillance programs across Japan.
The study identifies various metallo-beta-lactamase (MBL) genes, including blaIMP-1, blaIMP-7, blaIMP-10, blaIMP-6, blaIMP-11, blaVIM-1, and a novel fosI gene cassette, in MBL-producing Pseudomonas aeruginosa isolates across Japan.
Molecular analysis of the integrons of metallo-β-lactamase-producing Pseudomonas aeruginosa isolates collected by nationwide surveillance programs across Japan.
The study identifies various metallo-beta-lactamase (MBL) genes, including blaIMP-1, blaIMP-7, blaIMP-10, blaIMP-6, blaIMP-11, blaVIM-1, and a novel fosI gene cassette, in MBL-producing Pseudomonas aeruginosa isolates across Japan.
Dominance of IMP-4-producing enterobacter cloacae among carbapenemase-producing Enterobacteriaceae in Australia.
The study identifies blaIMP-4 as the predominant carbapenemase gene among carbapenemase-producing Enterobacteriaceae in Queensland, Australia, with a focus on Enterobacter cloacae. The gene was found in various species and was associated with HI2 plasmids.
Bacterial swarms recruit cargo bacteria to pave the way in toxic environments.
P. vortex can transport antibiotic-resistant cargo bacteria, such as E. coli expressing beta-lactamase, to detoxify beta-lactam antibiotics and enable co-dispersal.
Identification of Gram-Negative Bacteria and Genetic Resistance Determinants from Positive Blood Culture Broths by Use of the Verigene Gram-Negative Blood Culture Multiplex Microarray-Based Molecular Assay.
The Verigene Gram-Negative Blood Culture (BC-GN) assay effectively identifies Gram-negative bacteria and detects genetic resistance determinants such as bla CTX-M, bla KPC, bla NDM, bla OXA, bla VIM, and bla IMP in positive blood culture broths.
Emergence of Acinetobacter pittii Harboring New Delhi Metallo-β-Lactamase Genes in Daejeon, Korea
The study identified blaIMP-1 and blaNDM-1 genes in 21 ertapenem-resistant Acinetobacter pittii isolates in Korea. While blaIMP-1 conferred high resistance to imipenem and meropenem, blaNDM-1 showed variable susceptibility to these carbapenems.
Arginine-containing peptides as potent inhibitors of VIM-2 metallo-beta-lactamase.
The study identifies arginine-containing peptides as potent inhibitors of VIM-2 and IMP-1 metallo-beta-lactamases, highlighting their potential as therapeutic agents against β-lactam-resistant bacteria.
Elucidating the Role of Residue 67 in IMP-Type Metallo-β-Lactamase Evolution.
The study characterizes the role of residue 67 in IMP-type metallo-β-lactamases, showing that different amino acid substitutions at this position affect the hydrolytic activity and resistance profile towards various β-lactam antibiotics.
Elucidating the Role of Residue 67 in IMP-Type Metallo-β-Lactamase Evolution.
The study characterizes the role of residue 67 in IMP-type metallo-β-lactamases, showing that different amino acid substitutions at this position affect the hydrolytic activity and resistance profile towards various β-lactam antibiotics.
Genetic Characterization of Carbapenem-Resistant Enterobacteriaceae and the Spread of Carbapenem-Resistant Klebsiella pneumonia ST340 at a University Hospital in Thailand.
The study identified blaKPC-13 and blaIMP-14a as the carbapenemase genes responsible for carbapenem resistance in CRE isolates. blaKPC-13 was found in E. coli, E. cloacae, and C. freundii, while blaIMP-14a was found in K. pneumoniae. Additionally, reduced expression of ompK35 and ompK36 porin genes was associated with increased carbapenem MICs in some CRKP isolates.
Factors Associated to Prevalence and Incidence of Carbapenem-Resistant Enterobacteriaceae Fecal Carriage: A Cohort Study in a Mexican Tertiary Care Hospital.
The study identified OXA-232, CTX-M-15, SHV, NDM-1, KPC-1, and IMP as the primary molecular mechanisms of carbapenem resistance in CRE isolates. These genes were detected through PCR and sequencing.
High prevalence of Salmonella and IMP-4-producing Enterobacteriaceae in the silver gull on Five Islands, Australia.
The study identified the blaIMP-4, blaIMP-26, and blaIMP-38 genes in various Enterobacteriaceae isolates from silver gulls, highlighting the presence of carbapenemase-producing bacteria in wildlife.
High prevalence of Salmonella and IMP-4-producing Enterobacteriaceae in the silver gull on Five Islands, Australia.
The study identified the blaIMP-4, blaIMP-26, and blaIMP-38 genes in various Enterobacteriaceae isolates from silver gulls, highlighting the presence of carbapenemase-producing bacteria in wildlife.
High prevalence of Salmonella and IMP-4-producing Enterobacteriaceae in the silver gull on Five Islands, Australia.
The study identified the blaIMP-4, blaIMP-26, and blaIMP-38 genes in various Enterobacteriaceae isolates from silver gulls, highlighting the presence of carbapenemase-producing bacteria in wildlife.
Molecular detection of metallo-β-lactamase genes, bla IMP-1, bla VIM-2 and bla SPM-1 in imipenem resistant Pseudomonas aeruginosa isolated from clinical specimens in teaching hospitals of Ahvaz, Iran.
The study identified blaIMP-1 and blaVIM-2 genes as the primary contributors to imipenem resistance in Pseudomonas aeruginosa isolates from Ahvaz, Iran.
Xpert CARBA-R Assay for the Detection of Carbapenemase-Producing Organisms in Intensive Care Unit Patients of a Korean Tertiary Care Hospital
The Xpert CARBA-R assay detected carbapenemase-producing organisms (CPO) in ICU patients, identifying blaVIM, blaIMP, and blaKPC genes as responsible for carbapenem resistance.
Dissemination of carbapenemases producing Gram negative bacteria in the Middle East.
The study reviews the dissemination of carbapenemase-producing Gram-negative bacteria in the Middle East, highlighting the prevalence of KPC, VIM, IMP, NDM, and OXA-48 enzymes in various bacterial species such as Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa.
Outbreak of plasmid-mediated NDM-1-producing Klebsiella pneumoniae ST105 among neonatal patients in Yunnan, China.
The study identifies blaNDM-1, blaIMP-4, blaCTX-M-15, blaSHV-1, qnrS1, qnrB4, and aacA4 as the primary resistance genes in NDM-1-producing K. pneumoniae ST105 isolates during an outbreak in a neonatal ICU in China.
Antimicrobial Combinations against Pan-Resistant Acinetobacter baumannii Isolates with Different Resistance Mechanisms.
The study identified bla OXA-23-like, bla OXA-143-like, bla OXA-51-like, and bla IMP genes as major resistance mechanisms in pan-resistant Acinetobacter baumannii isolates. These genes conferred resistance to carbapenems, and the study highlighted the synergistic effects of various antibiotic combinations against these isolates.
A Carbapenem-Resistant Pseudomonas aeruginosa Isolate Harboring Two Copies of blaIMP-34 Encoding a Metallo-β-Lactamase.
The study identifies blaIMP-34, a metallo-beta-lactamase gene, as responsible for carbapenem resistance in a Pseudomonas aeruginosa isolate. The isolate harbors two chromosomal copies of blaIMP-34, contributing to high-level carbapenem resistance.
Multisite Evaluation of Cepheid Xpert Carba-R Assay for Detection of Carbapenemase-Producing Organisms in Rectal Swabs.
The Cepheid Xpert Carba-R assay effectively detects carbapenemase-producing organisms (CPO) by identifying specific carbapenemase genes, including blaIMP-1, blaVIM, blaNDM, blaKPC, and blaOXA-48, in rectal swab specimens.
Diverse Genetic Background of Multidrug-Resistant Pseudomonas aeruginosa from Mainland China, and Emergence of an Extensively Drug-Resistant ST292 Clone in Kunming.
The study identified various carbapenemase genes including blaIMP-9, blaIMP-1, blaIMP-10, blaVIM-2, and blaKPC-2 in multidrug-resistant Pseudomonas aeruginosa isolates from mainland China, highlighting the emergence of an extensively drug-resistant ST292 clone.
Diverse Genetic Background of Multidrug-Resistant Pseudomonas aeruginosa from Mainland China, and Emergence of an Extensively Drug-Resistant ST292 Clone in Kunming.
The study identified various carbapenemase genes including blaIMP-9, blaIMP-1, blaIMP-10, blaVIM-2, and blaKPC-2 in multidrug-resistant Pseudomonas aeruginosa isolates from mainland China, highlighting the emergence of an extensively drug-resistant ST292 clone.
Diverse Genetic Background of Multidrug-Resistant Pseudomonas aeruginosa from Mainland China, and Emergence of an Extensively Drug-Resistant ST292 Clone in Kunming.
The study identified various carbapenemase genes including blaIMP-9, blaIMP-1, blaIMP-10, blaVIM-2, and blaKPC-2 in multidrug-resistant Pseudomonas aeruginosa isolates from mainland China, highlighting the emergence of an extensively drug-resistant ST292 clone.
Transcriptome Profiling of Antimicrobial Resistance in Pseudomonas aeruginosa.
The study identifies multiple AMR genes and mutations in Pseudomonas aeruginosa, including aadA1, aadA6, aacA4, aacA7, aacA5, blaOXA-2, blaOXA-4, blaVIM-1, blaVIM-2, blaGIM-2, blaIMP-1, blaIMP-7, blaPER-1, blaCTX-M-3, ampC, gyrA (T83I), and parC (S87L/W), which are associated with resistance to various antibiotics such as tobramycin, ceftazidime, meropenem, and ciprofloxacin.
Transcriptome Profiling of Antimicrobial Resistance in Pseudomonas aeruginosa.
The study identifies multiple AMR genes and mutations in Pseudomonas aeruginosa, including aadA1, aadA6, aacA4, aacA7, aacA5, blaOXA-2, blaOXA-4, blaVIM-1, blaVIM-2, blaGIM-2, blaIMP-1, blaIMP-7, blaPER-1, blaCTX-M-3, ampC, gyrA (T83I), and parC (S87L/W), which are associated with resistance to various antibiotics such as tobramycin, ceftazidime, meropenem, and ciprofloxacin.
Antimicrobial Resistance Mechanisms
The paper discusses various mechanisms of antibiotic resistance, including beta-lactamases like blaKPC, blaNDM, blaIMP, and blaVIM, which confer resistance to carbapenems. It also covers aminoglycoside modifying enzymes such as aac(6')-Ib and aac(6')-I, quinolone resistance proteins like qnr, tetracycline resistance genes such as tet(M) and tet(O), macrolide resistance genes like erm, mefA, and mefE, and efflux pump systems like mexAB-oprM and acrAB-tolC.
Prevalence and Fate of Carbapenemase Genes in a Wastewater Treatment Plant in Northern China.
The study identified the prevalence of bla KPC-2, bla GES-1, and bla IMP-1 carbapenemase genes in a wastewater treatment plant, highlighting their persistence through various treatment stages and potential environmental dissemination.
First Report of blaIMP-14 on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131.
The study reports the first occurrence of the blaIMP-14 carbapenem resistance gene on a plasmid in Escherichia coli sequence type 131, highlighting the potential clinical concern due to its association with a multidrug resistance region.
Performance evaluation of three automated identification systems in detecting carbapenem-resistant Enterobacteriaceae.
The study identified carbapenemase genes blaIMP-4, blaIMP-8, blaNDM-1, and blaKPC-2 in carbapenem-resistant Enterobacteriaceae isolates.
Performance evaluation of three automated identification systems in detecting carbapenem-resistant Enterobacteriaceae.
The study identified carbapenemase genes blaIMP-4, blaIMP-8, blaNDM-1, and blaKPC-2 in carbapenem-resistant Enterobacteriaceae isolates.
Characteristics and management of Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemase in a tertiary hospital.
The study identifies the presence of IMP-4 and IMP-8 carbapenemases in Enterobacteriaceae isolates from a tertiary hospital in China, highlighting the need for improved surveillance and infection control measures.
Characteristics and management of Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemase in a tertiary hospital.
The study identifies the presence of IMP-4 and IMP-8 carbapenemases in Enterobacteriaceae isolates from a tertiary hospital in China, highlighting the need for improved surveillance and infection control measures.
Interspecies Dissemination of a Mobilizable Plasmid Harboring blaIMP-19 and the Possibility of Horizontal Gene Transfer in a Single Patient.
The study demonstrates the horizontal transfer of a plasmid carrying the blaIMP-19 gene from Achromobacter xylosoxidans to Klebsiella pneumoniae in a single patient, highlighting the potential for interspecies dissemination of carbapenem resistance.
Structural and Mutagenic Analysis of Metallo-beta-lactamase IMP-18.
The study characterizes the metallo-beta-lactamase IMP-18 from Pseudomonas aeruginosa and identifies key mutations in the flap loop region that enhance its hydrolytic activity towards carbapenems.
Class 1 integrons in non-clonal multidrug-resistant Acinetobacter baumannii from Iran, description of the new blaIMP-55 allele in In1243.
Use of Cepheid Xpert Carba-R® for Rapid Detection of Carbapenemase-Producing Bacteria in Abdominal Septic Patients Admitted to Intensive Care Unit.
The study evaluates the effectiveness of the Xpert Carba-R assay in detecting carbapenemase-producing bacteria in abdominal septic patients. It identifies several carbapenem resistance genes, including bla KPC, bla VIM, bla OXA-48, bla IMP-1, and bla NDM, which are associated with resistance to carbapenems.
IMP-27, a Unique Metallo-β-Lactamase Identified in Geographically Distinct Isolates of Proteus mirabilis.
A novel metallo-β-lactamase gene, blaIMP-27, was identified in Proteus mirabilis isolates from the United States, which conferred resistance to ertapenem but not to aztreonam, ceftazidime, or piperacillin-tazobactam.
IMP-27, a Unique Metallo-β-Lactamase Identified in Geographically Distinct Isolates of Proteus mirabilis.
IMP-27, a Unique Metallo-β-Lactamase Identified in Geographically Distinct Isolates of Proteus mirabilis.
IMP-27, a Unique Metallo-β-Lactamase Identified in Geographically Distinct Isolates of Proteus mirabilis.
IMP-27, a Unique Metallo-β-Lactamase Identified in Geographically Distinct Isolates of Proteus mirabilis.
Genome and Plasmid Analysis of blaIMP-4-Carrying Citrobacter freundii B38.
The study identifies the blaIMP-4 gene in Citrobacter freundii B38, which confers resistance to carbapenems. The gene is part of a class 1 integron on plasmid pOZ172, along with other resistance determinants.
Prevalence and Molecular Characteristics of Carbapenemase-Producing Enterobacteriaceae From Five Hospitals in Korea.
The study identified bla_OXA-232, bla_KPC-2, bla_IMP-1, and bla_NDM-1 genes as the primary carbapenemase genes in carbapenemase-producing Enterobacteriaceae (CPE) isolates from five hospitals in Korea.
Clonal Dissemination of Pseudomonas aeruginosa Sequence Type 235 Isolates Carrying blaIMP-6 and Emergence of blaGES-24 and blaIMP-10 on Novel Genomic Islands PAGI-15 and -16 in South Korea.
The study identifies blaIMP-6, blaGES-24, and blaIMP-10 genes on novel genomic islands PAGI-15 and PAGI-16 in Pseudomonas aeruginosa ST235 isolates in South Korea, highlighting the clonal dissemination of these carbapenemase genes.
Clonal Dissemination of Pseudomonas aeruginosa Sequence Type 235 Isolates Carrying blaIMP-6 and Emergence of blaGES-24 and blaIMP-10 on Novel Genomic Islands PAGI-15 and -16 in South Korea.
The study identifies blaIMP-6, blaGES-24, and blaIMP-10 genes on novel genomic islands PAGI-15 and PAGI-16 in Pseudomonas aeruginosa ST235 isolates in South Korea, highlighting the clonal dissemination of these carbapenemase genes.
Insights on the Horizontal Gene Transfer of Carbapenemase Determinants in the Opportunistic Pathogen Acinetobacter baumannii.
The paper discusses the horizontal gene transfer of carbapenemase determinants in Acinetobacter baumannii, focusing on various carbapenemase genes such as bla OXA-23, bla OXA-40, bla OXA-58, bla OXA-143, and bla OXA-235, highlighting their roles in carbapenem resistance and the mechanisms of their dissemination.
Emergence of New Delhi metallo-beta-lactamase 1 and other carbapenemase-producing Acinetobacter calcoaceticus-baumannii complex among patients in hospitals in Ha Noi, Viet Nam.
The study identifies NDM-1, IMP-1, OXA-23, and OXA-58 as carbapenem resistance genes in Acinetobacter baumannii isolates from hospitals in Hanoi, Vietnam. It reports the coexistence of NDM-1 and IMP-1 for the first time in Vietnam.
Antimicrobial susceptibility testing in predicting the presence of carbapenemase genes in Enterobacteriaceae in South Africa.
The study identified bla_NDM, bla_OXA-48, bla_VIM, bla_IMP, bla_GES, and bla_KPC as the most prevalent carbapenemase genes in Enterobacteriaceae isolates in South Africa, with bla_NDM being the most common.
Isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from cats.
The study identifies the blaIMP-4 gene in Salmonella enterica Typhimurium from cats, which confers resistance to carbapenems. The gene is part of a multidrug-resistant IncHI2 plasmid carrying various resistance genes.
Significance of nucleic acid testing in diagnosis and treatment of post-neurosurgical meningitis caused by multidrug-resistant Acinetobacter baumannii: a case report.
The case report highlights the importance of molecular techniques in diagnosing post-neurosurgical meningitis caused by multidrug-resistant Acinetobacter baumannii, identifying the presence of VEB, NDM-1, IMP, and OXA-58 genes.
The rapid spread of carbapenem-resistant Enterobacteriaceae.
The paper discusses the rapid spread of carbapenem-resistant Enterobacteriaceae (CRE) and characterizes various carbapenemase genes such as bla KPC, bla NDM, bla VIM, bla OXA-48, and bla IMP, highlighting their roles in conferring resistance to carbapenems.
The rapid spread of carbapenem-resistant Enterobacteriaceae.
The paper discusses the rapid spread of carbapenem-resistant Enterobacteriaceae (CRE) and characterizes various carbapenemase genes such as bla KPC, bla NDM, bla VIM, bla OXA-48, and bla IMP, highlighting their roles in conferring resistance to carbapenems.
Comparison of phenotypic and PCR methods for detection of carbapenemases production by Enterobacteriaceae.
The study identified the presence of various carbapenemase genes, including blaIMP, blaVIM, blaNDM, blaKPC, and blaOXA-48, in Enterobacteriaceae isolates, highlighting the importance of molecular methods for rapid and accurate detection of carbapenemase-producing organisms.
The emergence of carbapenem resistant Klebsiella pneumoniae in Malaysia: correlation between microbiological trends with host characteristics and clinical factors.
The study identified several carbapenemase genes, including bla_OXA-48, bla_KPC-2, bla_IMP-8, bla_NDC-1, and bla_NMC-A, in carbapenem-resistant Klebsiella pneumoniae strains isolated in Malaysia. These genes were associated with resistance to carbapenems and other antibiotics.
Comparison of 11 Phenotypic Assays for Accurate Detection of Carbapenemase-Producing Enterobacteriaceae
The study evaluates 11 phenotypic assays for the detection of carbapenemase-producing Enterobacteriaceae (CPE) and identifies the effectiveness of various assays in detecting different types of carbapenemase genes, including bla KPC, bla NDM, bla OXA-48-type, bla VIM, bla IMP, bla SME, and bla IMI.
Nosocomial Infections with IMP-19-Producing Pseudomonas aeruginosa Linked to Contaminated Sinks, France.
The study identifies blaIMP-19 as a metallo-beta-lactamase gene responsible for resistance to carbapenems in Pseudomonas aeruginosa isolates linked to contaminated sinks in a French hospital.
Carbapenem Susceptibility and Multidrug-Resistance in Pseudomonas aeruginosa Isolates in Egypt.
The study identified Metallo-β-Lactamase (MBL) and Amp C β-lactamase production in Pseudomonas aeruginosa isolates from Egypt, highlighting the prevalence of carbapenem resistance and multidrug resistance.
Molecular Characteristics of Carbapenem-Resistant Enterobacter cloacae in Ningxia Province, China.
The study identified blaNDM-1, blaKPC, blaIMP, and blaVIM as the main carbapenem resistance genes in carbapenem-resistant Enterobacter cloacae isolates from Ningxia, China. These genes were found in multiple isolates and could be transferred to Escherichia coli via conjugation.
Development of a Rapid Reverse Blot Hybridization Assay for Detection of Clinically Relevant Antibiotic Resistance Genes in Blood Cultures Testing Positive for Gram-Negative Bacteria.
The study developed and evaluated the REBA-EAC assay for the rapid detection of clinically relevant antibiotic resistance genes in blood cultures positive for Gram-negative bacteria. The assay successfully identified various beta-lactamase genes, including ESBLs (CTX-M, TEM, SHV), AmpC beta-lactamases (DHA, CMY-2-like, ACT), and carbapenemases (IMP, VIM, NDM, KPC, OXA-48-like, SPM).
Rapid detection of carbapenemase-producing Klebsiella pneumoniae strains derived from blood cultures by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS).
The study demonstrates the rapid detection of carbapenemase-producing Klebsiella pneumoniae strains using MALDI-TOF MS, identifying various carbapenemase genes including bla KPC, bla NDM, bla OXA-48, bla VIM, bla IMP, bla SHV, bla TEM, and bla CTX-M.
Insight into stereochemistry of a new IMP allelic variant (IMP-55) metallo-β-lactamase identified in a clinical strain of Acinetobacter baumannii.
Insight into stereochemistry of a new IMP allelic variant (IMP-55) metallo-β-lactamase identified in a clinical strain of Acinetobacter baumannii.
Insight into stereochemistry of a new IMP allelic variant (IMP-55) metallo-β-lactamase identified in a clinical strain of Acinetobacter baumannii.
Development of selective medium for IMP-type carbapenemase-producing Enterobacteriaceae in stool specimens.
The study developed a selective medium, M-ECC, for the detection of IMP-type carbapenemase-producing Enterobacteriaceae (CPE), demonstrating improved sensitivity compared to existing methods.
Development of selective medium for IMP-type carbapenemase-producing Enterobacteriaceae in stool specimens.
The study developed a selective medium, M-ECC, for the detection of IMP-type carbapenemase-producing Enterobacteriaceae (CPE), demonstrating improved sensitivity compared to existing methods.
Development of selective medium for IMP-type carbapenemase-producing Enterobacteriaceae in stool specimens.
The study developed a selective medium, M-ECC, for the detection of IMP-type carbapenemase-producing Enterobacteriaceae (CPE), demonstrating improved sensitivity compared to existing methods.
Use of Ancillary Carbapenemase Tests To Improve Specificity of Phenotypic Definitions for Carbapenemase-Producing Enterobacteriaceae.
The study evaluated the performance of ancillary carbapenemase tests, such as the Xpert Carba-R and the carbapenem inactivation method (CIM), to improve the specificity of phenotypic definitions for carbapenemase-producing Enterobacteriaceae (CPE). It identified various carbapenemase genes, including bla IMP, bla KPC, bla NDM, and bla OXA-48-like, and their association with resistance to carbapenems.
The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace.
The paper discusses the global spread and mechanisms of carbapenem resistance in Enterobacteriaceae, highlighting the role of various beta-lactamase genes such as blaKPC, blaNDM, blaVIM, blaIMP, and blaOXA-48 in conferring resistance to carbapenems.
Distribution of Integrons and Phylogenetic Groups among Enteropathogenic Escherichia coli Isolates from Children <5 Years of Age in Delhi, India.
The study identified various AMR genes including dfrA1, dfrA7, dfrA12, aadA1, aadA2, sul1, tetA, aacC1, TEM, SHV, CTX-M, OXA, NDM-1, IMP, VIM, ACT, DHA, and CMY in E. coli isolates from children in Delhi, India. These genes were associated with resistance to multiple antibiotics such as trimethoprim, streptomycin, sulfonamides, tetracycline, gentamicin, and various beta-lactams.
Characteristics of carbapenemase-producing Klebsiella pneumoniae as a cause of neonatal infection in Shandong, China.
The study identified bla NDM-1 and bla IMP-4 as the predominant resistance genes in carbapenem-resistant Klebsiella pneumoniae isolates causing neonatal infections in Shandong, China.
Characterization of the Complete Nucleotide Sequences of IncA/C2 Plasmids Carrying In809-Like Integrons from Enterobacteriaceae Isolates of Wildlife Origin.
The study characterized IncA/C2 plasmids carrying In809-like integrons from Enterobacteriaceae isolates of wildlife origin, identifying several AMR genes including blaIMP-4, blaIMP-26, blaIMP-38, sul2, floR, aac(3)-IId, qnrA1, arr-3, dfrA12, aphA1, aadA16, aadA2, blaOXA-1, blaTEM-1, and blaDHA-1.
Characterization of the Complete Nucleotide Sequences of IncA/C2 Plasmids Carrying In809-Like Integrons from Enterobacteriaceae Isolates of Wildlife Origin.
The study characterized IncA/C2 plasmids carrying In809-like integrons from Enterobacteriaceae isolates of wildlife origin, identifying several AMR genes including blaIMP-4, blaIMP-26, blaIMP-38, sul2, floR, aac(3)-IId, qnrA1, arr-3, dfrA12, aphA1, aadA16, aadA2, blaOXA-1, blaTEM-1, and blaDHA-1.
Characterization of the Complete Nucleotide Sequences of IncA/C2 Plasmids Carrying In809-Like Integrons from Enterobacteriaceae Isolates of Wildlife Origin.
The study characterized IncA/C2 plasmids carrying In809-like integrons from Enterobacteriaceae isolates of wildlife origin, identifying several AMR genes including blaIMP-4, blaIMP-26, blaIMP-38, sul2, floR, aac(3)-IId, qnrA1, arr-3, dfrA12, aphA1, aadA16, aadA2, blaOXA-1, blaTEM-1, and blaDHA-1.
Molecular detection of beta-lactamase and integron genes in clinical strains of Klebsiella pneumoniae by multiplex polymerase chain reaction.
The study identified the presence of various beta-lactamase genes (blaTEM, blaCTX-M, blaSHV, blaPER, blaGES, blaVIM, blaIMP, blaOXA, blaKPC) and integron genes (intI, intII, intIII) in clinical strains of Klebsiella pneumoniae, highlighting the prevalence of multidrug resistance.
Determination of carbapenem resistance mechanism in clinical isolates of Pseudomonas aeruginosa isolated from burn patients, in Tehran, Iran.
Carbapenem resistance in Pseudomonas aeruginosa isolates from burn patients in Tehran, Iran, is primarily mediated by blaVIM and blaIMP carbapenemase genes, oprD mutations, and AmpC overproduction.
Emergence of carbapenemase-producing urinary isolates at a tertiary care hospital in Dhaka, Bangladesh.
The study identified the presence of various carbapenemase genes, including bla NDM-1, bla OXA-48, bla OXA-181, bla KPC, bla VIM, and bla IMP, in carbapenem-resistant Gram-negative uropathogens in Bangladesh.
Resistance to Antibiotics, Biocides, Preservatives and Metals in Bacteria Isolated from Seafoods: Co-Selection of Strains Resistant or Tolerant to Different Classes of Compounds.
The study identified multiple antibiotic resistance genes, including sul1, sul2, floR, aadA1, aac(6')-Ib, blaTEM, blaCTX-M, blaPSE, blaNDM-1, qacEΔ1, pcoA/copA, chrB, and pcoR, in bacterial isolates from seafood. These genes conferred resistance to sulfonamides, phenicols, aminoglycosides, beta-lactams, and heavy metals.
A Modified Carbapenem Inactivation Method, CIMTris, for Carbapenemase Production in Acinetobacter and Pseudomonas Species.
The study introduces a modified carbapenem inactivation method, CIMTris, which shows higher sensitivity than the mCIM for detecting carbapenemase production in Acinetobacter and Pseudomonas species. Several carbapenemase genes, including blaIMP-10, blaIMP-14, blaIMP-15, blaIMP-26, blaIMP-34, blaIMP-43, blaIMP-44, blaIMP-51, blaNDM-1, blaVIM-1, blaVIM-2, blaGES-5, blaGES-6, blaOXA-23, blaOXA-58, blaOXA-72, blaOXA-69, blaOXA-82, blaOXA-98, and blaOXA-51-like, were identified and validated in this study.
A Modified Carbapenem Inactivation Method, CIMTris, for Carbapenemase Production in Acinetobacter and Pseudomonas Species.
The study introduces a modified carbapenem inactivation method, CIMTris, which shows higher sensitivity than the mCIM for detecting carbapenemase production in Acinetobacter and Pseudomonas species. Several carbapenemase genes, including blaIMP-10, blaIMP-14, blaIMP-15, blaIMP-26, blaIMP-34, blaIMP-43, blaIMP-44, blaIMP-51, blaNDM-1, blaVIM-1, blaVIM-2, blaGES-5, blaGES-6, blaOXA-23, blaOXA-58, blaOXA-72, blaOXA-69, blaOXA-82, blaOXA-98, and blaOXA-51-like, were identified and validated in this study.
A Modified Carbapenem Inactivation Method, CIMTris, for Carbapenemase Production in Acinetobacter and Pseudomonas Species.
The study introduces a modified carbapenem inactivation method, CIMTris, which shows higher sensitivity than the mCIM for detecting carbapenemase production in Acinetobacter and Pseudomonas species. Several carbapenemase genes, including blaIMP-10, blaIMP-14, blaIMP-15, blaIMP-26, blaIMP-34, blaIMP-43, blaIMP-44, blaIMP-51, blaNDM-1, blaVIM-1, blaVIM-2, blaGES-5, blaGES-6, blaOXA-23, blaOXA-58, blaOXA-72, blaOXA-69, blaOXA-82, blaOXA-98, and blaOXA-51-like, were identified and validated in this study.
A Modified Carbapenem Inactivation Method, CIMTris, for Carbapenemase Production in Acinetobacter and Pseudomonas Species.
The study introduces a modified carbapenem inactivation method, CIMTris, which shows higher sensitivity than the mCIM for detecting carbapenemase production in Acinetobacter and Pseudomonas species. Several carbapenemase genes, including blaIMP-10, blaIMP-14, blaIMP-15, blaIMP-26, blaIMP-34, blaIMP-43, blaIMP-44, blaIMP-51, blaNDM-1, blaVIM-1, blaVIM-2, blaGES-5, blaGES-6, blaOXA-23, blaOXA-58, blaOXA-72, blaOXA-69, blaOXA-82, blaOXA-98, and blaOXA-51-like, were identified and validated in this study.
A Modified Carbapenem Inactivation Method, CIMTris, for Carbapenemase Production in Acinetobacter and Pseudomonas Species.
The study introduces a modified carbapenem inactivation method, CIMTris, which shows higher sensitivity than the mCIM for detecting carbapenemase production in Acinetobacter and Pseudomonas species. Several carbapenemase genes, including blaIMP-10, blaIMP-14, blaIMP-15, blaIMP-26, blaIMP-34, blaIMP-43, blaIMP-44, blaIMP-51, blaNDM-1, blaVIM-1, blaVIM-2, blaGES-5, blaGES-6, blaOXA-23, blaOXA-58, blaOXA-72, blaOXA-69, blaOXA-82, blaOXA-98, and blaOXA-51-like, were identified and validated in this study.
A Modified Carbapenem Inactivation Method, CIMTris, for Carbapenemase Production in Acinetobacter and Pseudomonas Species.
The study introduces a modified carbapenem inactivation method, CIMTris, which shows higher sensitivity than the mCIM for detecting carbapenemase production in Acinetobacter and Pseudomonas species. Several carbapenemase genes, including blaIMP-10, blaIMP-14, blaIMP-15, blaIMP-26, blaIMP-34, blaIMP-43, blaIMP-44, blaIMP-51, blaNDM-1, blaVIM-1, blaVIM-2, blaGES-5, blaGES-6, blaOXA-23, blaOXA-58, blaOXA-72, blaOXA-69, blaOXA-82, blaOXA-98, and blaOXA-51-like, were identified and validated in this study.
A Modified Carbapenem Inactivation Method, CIMTris, for Carbapenemase Production in Acinetobacter and Pseudomonas Species.
The study introduces a modified carbapenem inactivation method, CIMTris, which shows higher sensitivity than the mCIM for detecting carbapenemase production in Acinetobacter and Pseudomonas species. Several carbapenemase genes, including blaIMP-10, blaIMP-14, blaIMP-15, blaIMP-26, blaIMP-34, blaIMP-43, blaIMP-44, blaIMP-51, blaNDM-1, blaVIM-1, blaVIM-2, blaGES-5, blaGES-6, blaOXA-23, blaOXA-58, blaOXA-72, blaOXA-69, blaOXA-82, blaOXA-98, and blaOXA-51-like, were identified and validated in this study.
A Modified Carbapenem Inactivation Method, CIMTris, for Carbapenemase Production in Acinetobacter and Pseudomonas Species.
The study introduces a modified carbapenem inactivation method, CIMTris, which shows higher sensitivity than the mCIM for detecting carbapenemase production in Acinetobacter and Pseudomonas species. Several carbapenemase genes, including blaIMP-10, blaIMP-14, blaIMP-15, blaIMP-26, blaIMP-34, blaIMP-43, blaIMP-44, blaIMP-51, blaNDM-1, blaVIM-1, blaVIM-2, blaGES-5, blaGES-6, blaOXA-23, blaOXA-58, blaOXA-72, blaOXA-69, blaOXA-82, blaOXA-98, and blaOXA-51-like, were identified and validated in this study.
Simple, rapid, and cost-effective modified Carba NP test for carbapenemase detection among Gram-negative bacteria.
The study evaluated modified Carba NP (mCNP) test for rapid detection of carbapenemases among Gram-negative bacteria. It identified bla NDM, bla IMP, bla VIM, bla OXA-48-like, and bla KPC genes as prevalent carbapenemase genes in carbapenem-resistant isolates.
High-Stringency Evaluation of the Automated BD Phoenix CPO Detect and Rapidec Carba NP Tests for Detection and Classification of Carbapenemases.
The study evaluated the BD Phoenix CPO Detect and Rapidec Carba NP tests for detecting and classifying carbapenemases. Both tests showed high sensitivity for carbapenemase detection, with the BD Phoenix CPO Detect also providing classification of carbapenemases.
Multicenter Evaluation of the Modified Carbapenem Inactivation Method and the Carba NP for Detection of Carbapenemase-Producing Pseudomonas aeruginosa and Acinetobacter baumannii.
The study characterizes various carbapenemase genes, including blaVIM, blaIMP, blaKPC, blaNDM, blaSPM, blaOXA-23, blaOXA-24/40, blaOXA-58, blaOXA-72, and blaOXA-237, which confer resistance to carbapenems in Pseudomonas aeruginosa and Acinetobacter baumannii.
Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014.
The study identified various carbapenemase genes including bla KPC, bla NDM, bla OXA-48-like, bla VIM, bla IMI, and bla IMP in different Enterobacteriaceae species. These genes conferred resistance to carbapenems. Additionally, mutations in pmrA and pmrB were associated with colistin resistance in Klebsiella pneumoniae.
Distribution and Molecular Characterization of Acinetobacter baumannii International Clone II Lineage in Japan.
The study identified carbapenem resistance genes such as bla OXA-23-like, bla OXA-51-like, and bla IMP in Acinetobacter baumannii isolates, along with the bla ADC gene associated with cephalosporin resistance. These genes were found in different sequence types of A. baumannii, contributing to varying levels of antimicrobial resistance.
Detection of metallo-β-lactamases-encoding genes among clinical isolates of Pseudomonas aeruginosa in a tertiary care hospital, Kathmandu, Nepal.
The study detected blaVIM-2 and blaIMP-1 genes in Pseudomonas aeruginosa isolates, which conferred resistance to imipenem, meropenem, and ceftazidime.
A novel Tn1696-like composite transposon (Tn6404) harboring bla (IMP-4) in a Klebsiella pneumoniae isolate carrying a rare ESBL gene bla (SFO-1).
The study identifies a novel Tn1696-like transposon (Tn6404) harboring the carbapenemase gene blaIMP-4 and the rare ESBL gene blaSFO-1 in a multidrug-resistant Klebsiella pneumoniae isolate. Both genes were experimentally validated for their resistance mechanisms.
Antimicrobial susceptibility and molecular epidemiology of clinical Enterobacter cloacae bloodstream isolates in Shanghai, China.
The study identified several AMR genes in Enterobacter cloacae bloodstream isolates, including ESBLs (SHV-12, CTX-M-15, CTX-M-65), carbapenemases (IMP-26, NDM-1), plasmid-mediated AmpC beta-lactamases (ACT-20, ACT-3, DHA-1), and TEM-1. These genes were associated with resistance to various antibiotics, highlighting the need for continued surveillance.
Pseudomonas aeruginosa-producing Metallo-β-lactamases (VIM, IMP, SME, and AIM) in the Clinical Isolates of Intensive Care Units, a University Hospital in Isfahan, Iran.
The study identified blaIMP and blaVIM genes in Pseudomonas aeruginosa isolates from ICU patients in Iran, indicating their role in carbapenem resistance.
Evaluation of the Amplidiag CarbaR+VRE Kit for Accurate Detection of Carbapenemase-Producing Bacteria.
The Amplidiag CarbaR+VRE assay effectively detects various carbapenemase genes, including blaKPC, blaNDM, blaVIM, blaIMP, blaOXA-48, blaOXA-23, blaOXA-58, and blaOXA-51, in different bacterial species.
Molecular Characterization of IMP-1-Producing Enterobacter cloacae Complex Isolates in Tokyo.
The study identified blaIMP-1 as a key gene responsible for carbapenem resistance in Enterobacter cloacae complex isolates in Tokyo, highlighting the role of IncHI2 and IncW plasmids in its dissemination.
Antimicrobial-Resistant Klebsiella pneumoniae Carriage and Infection in Specialized Geriatric Care Wards Linked to Acquisition in the Referring Hospital.
The study identified bla CTX-M-15 and bla IMP-26 as the primary AMR genes in ESBL and carbapenem-resistant K. pneumoniae isolates, highlighting the role of plasmids in the dissemination of these resistance genes.
Characteristics of Carbapenemase-Producing Enterobacteriaceae in Wastewater Revealed by Genomic Analysis.
The study identified various carbapenemase-encoding genes, including bla GES-5, bla GES-6, bla GES-24, bla NDM-5, bla IMP-8, bla IMP-19, bla KPC-2, and bla VIM-1, in carbapenemase-producing Enterobacteriaceae (CPE) isolated from wastewater in Japan and Taiwan.
Characteristics of Carbapenemase-Producing Enterobacteriaceae in Wastewater Revealed by Genomic Analysis.
The study identified various carbapenemase-encoding genes, including bla GES-5, bla GES-6, bla GES-24, bla NDM-5, bla IMP-8, bla IMP-19, bla KPC-2, and bla VIM-1, in carbapenemase-producing Enterobacteriaceae (CPE) isolated from wastewater in Japan and Taiwan.
bla(IMP-27) on transferable plasmids in Proteus mirabilis and Providencia rettgeri.
The study identifies bla(IMP-27) as a carbapenemase gene carried on transferable plasmids in Proteus mirabilis and Providencia rettgeri, demonstrating its ability to confer carbapenem resistance upon transfer to E. coli.
Molecular epidemiology and drug resistant mechanism in carbapenem-resistant Klebsiella pneumoniae isolated from pediatric patients in Shanghai, China.
The study identified various AMR genes in CR-KP isolates, including blaNDM-1, blaIMP, blaKPC-2, SHV, TEM, CTX-M, aac(6')-Ib-cr, qnrS1, qnrB4, oqxAB, and rmtB, which contribute to resistance against carbapenems, beta-lactams, aminoglycosides, and fluoroquinolones.
bla(VIM) and bla(IMP) Genes Detection in Isolates of Carbapenem Resistant P. aeruginosa of Hospitalized Patients in Two Hospitals in Iran.
The study detected bla(VIM) and bla(IMP) genes in 6 (5.8%) and 2 (1.9%) of 19 MBL-producing P. aeruginosa isolates, respectively, indicating their role in carbapenem resistance.
Factors associated to prevalence and treatment of carbapenem-resistant Enterobacteriaceae infections: a seven years retrospective study in three tertiary care hospitals.
The study identified IMP-4 and IMP-8 carbapenemases as the main resistance mechanisms in carbapenem-resistant Enterobacteriaceae (CRE) infections. These enzymes were prevalent in various CRE pathogens, including Klebsiella pneumoniae, Enterobacter cloacae, and others.
Factors associated to prevalence and treatment of carbapenem-resistant Enterobacteriaceae infections: a seven years retrospective study in three tertiary care hospitals.
The study identified IMP-4 and IMP-8 carbapenemases as the main resistance mechanisms in carbapenem-resistant Enterobacteriaceae (CRE) infections. These enzymes were prevalent in various CRE pathogens, including Klebsiella pneumoniae, Enterobacter cloacae, and others.
Rapid Identification of bla(IMP-1) and bla(IMP-6) by Multiplex Amplification Refractory Mutation System PCR.
The study developed a multiplex ARMS PCR assay to rapidly identify bla(IMP-1) and bla(IMP-6) genes, which encode metallo-beta-lactamases responsible for carbapenem resistance in clinical isolates.
Rapid Identification of bla(IMP-1) and bla(IMP-6) by Multiplex Amplification Refractory Mutation System PCR.
The study developed a multiplex ARMS PCR assay to rapidly identify bla(IMP-1) and bla(IMP-6) genes, which encode metallo-beta-lactamases responsible for carbapenem resistance in clinical isolates.
Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food.
The study identifies various carbapenemase genes, including blaKPC-2, blaIMP-4, blaNDM-1, blaNDM-5, blaVIM-2, and blaOXA-48, in non-typhoidal Salmonella enterica serovars from humans, animals, and food sources, highlighting the emergence of carbapenem resistance in these pathogens.
Rapid detection of carbapenemase activity of Enterobacteriaceae isolated from positive blood cultures by MALDI-TOF MS.
The study developed a MALDI-TOF MS-based ertapenem hydrolysis assay to rapidly detect carbapenemase activity in Enterobacteriaceae strains from positive blood cultures, identifying several carbapenemase genes including blaKPC, blaNDM, blaIMP, blaVIM, blaGES, and blaOXA-48.
Metallo-β-lactamase-mediated resistance among clinical carbapenem-resistant Pseudomonas aeruginosa isolates in northern Iran: A potential threat to clinical therapeutics.
The study identified blaIMP, blaVIM, and blaNDM genes as major contributors to carbapenem resistance in Pseudomonas aeruginosa isolates in northern Iran.
Risk Factors for Gastrointestinal Colonization and Acquisition of Carbapenem-Resistant Gram-Negative Bacteria among Patients in Intensive Care Units in Thailand.
The study identified carbapenemase genes bla OXA-23, bla OXA-24, bla OXA-51, bla OXA-58, bla NDM, and bla IMP in carbapenem-resistant Gram-negative bacteria, highlighting their role in resistance.
Molecular Typing and Carbapenem Resistance Mechanisms of Pseudomonas aeruginosa Isolated From a Chinese Burn Center From 2011 to 2016.
Within-a-Day Detection and Rapid Characterization of Carbapenemase by Use of a New Carbapenem Inactivation Method-Based Test, CIMplus.
The study evaluates the CIMplus test for rapid detection and characterization of carbapenemase-producing Enterobacteriaceae (CPE), demonstrating high sensitivity and specificity in identifying various carbapenemase types, including KPC, GES, NDM, VIM, IMP, OXA-48, and OXA-181.
Molecular Characterization of Carbapenem-Resistant Enterobacter cloacae in 11 Chinese Cities.
The study identified various carbapenemase genes, including blaNDM-1, blaIMP-4, blaKPC-2, and blaVIM-1, in carbapenem-resistant Enterobacter cloacae strains from 11 Chinese cities. These genes conferred resistance to multiple beta-lactam antibiotics.
Virtual Screening and Experimental Testing of B1 Metallo-β-lactamase Inhibitors.
The study identified and experimentally validated several B1 metallo-beta-lactamase inhibitors, including compounds 11993658, 24897966, 6821770, and 23978304, which showed potent inhibition against NDM-1, IMP-1, and VIM-2.
Drug Resistance and Molecular Epidemiology of Carbapenem Resistant Gram-negative Bacilli Isolates.
The study identifies blaNDM-1 as the most prevalent metallo-beta-lactamase gene among carbapenem-resistant Gram-negative bacilli, followed by blaVIM and blaIMP. These genes confer resistance to carbapenems.
Related carbapenemase-producing Klebsiella isolates detected in both a hospital and associated aquatic environment in Sweden.
The study identified carbapenemase-producing Klebsiella isolates in both hospital and aquatic environments in Sweden, highlighting the presence of blaVIM-1, blaIMP-29, blaNDM-1, blaKPC-3, and blaOXA-48 genes in various Klebsiella species.
Comparative genomics of five different resistance plasmids coexisting in a clinical multi-drug resistant Citrobacter freundii isolate.
The study identifies five resistance plasmids in a clinical Citrobacter freundii isolate, each carrying multiple AMR genes, including bla NDM-1, bla IMP-4, qnrS1, bla KPC-2, catB3, and mph (A), contributing to multidrug resistance.
Characterization of antimicrobial resistance mechanisms in carbapenem-resistant Pseudomonas aeruginosa carrying IMP variants recovered from a Mexican Hospital.
The study identifies three novel β-lactamase variants (bla GES-32, bla IMP-56, and bla IMP-62) within new class 1 integron configurations and detects two plasmids carrying bla IMP in a single P. aeruginosa strain. Mutations in the oprD gene, including stop codons and insertions, contribute to carbapenem resistance.
Characterization of antimicrobial resistance mechanisms in carbapenem-resistant Pseudomonas aeruginosa carrying IMP variants recovered from a Mexican Hospital.
The study identifies three novel β-lactamase variants (bla GES-32, bla IMP-56, and bla IMP-62) within new class 1 integron configurations and detects two plasmids carrying bla IMP in a single P. aeruginosa strain. Mutations in the oprD gene, including stop codons and insertions, contribute to carbapenem resistance.
Characterization of antimicrobial resistance mechanisms in carbapenem-resistant Pseudomonas aeruginosa carrying IMP variants recovered from a Mexican Hospital.
The study identifies three novel β-lactamase variants (bla GES-32, bla IMP-56, and bla IMP-62) within new class 1 integron configurations and detects two plasmids carrying bla IMP in a single P. aeruginosa strain. Mutations in the oprD gene, including stop codons and insertions, contribute to carbapenem resistance.
Phenotypic and molecular detection of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from patients with burns in Tehran, Iran.
The study identified bla VIM-1, bla IMP-1, and bla SPM-1 genes as the primary metallo-beta-lactamase-encoding genes in Pseudomonas aeruginosa isolates from burn patients in Tehran, Iran.
Establishment of a dual-wavelength spectrophotometric method for analysing and detecting carbapenemase-producing Enterobacteriaceae.
The study established a dual-wavelength spectrophotometric method for detecting carbapenemase-producing Enterobacteriaceae (CPE) by analyzing imipenem hydrolysis. The method effectively identified CPE strains carrying blaIMP, blaKPC, blaNDM, blaOXA, and blaVIM genes.
Prospective evaluation of a screening algorithm for carbapenemase-producing Enterobacteriaceae.
The study evaluated a screening algorithm for carbapenemase-producing Enterobacteriaceae (CPE) and identified several carbapenemase genes, including bla KPC, bla NDM, bla VIM, bla IMP, bla OXA-48, and bla OXA-181, which confer resistance to carbapenems.
High frequency and molecular epidemiology of metallo-β-lactamase-producing gram-negative bacilli in a tertiary care hospital in Lahore, Pakistan.
The study identified the prevalence of metallo-beta-lactamase (MBL)-producing gram-negative bacilli in a tertiary care hospital in Lahore, Pakistan. It found that bla TEM, bla SHV, bla OXA, bla IMP-1, and bla VIM genes were frequently present in imipenem-resistant isolates, indicating the coexistence of extended-spectrum beta-lactamase (ESBL) and MBL genes.
Characterization of Gene Families Encoding Beta-Lactamases of Gram-Negative Rods Isolated from Ready-to-Eat Vegetables in Mexico City.
The study identified various beta-lactamase genes, including blaBIL, blaSHV, blaCTX, blaDHA, blaVIM, blaOXA, blaIMP, blaKPC, and blaTEM, which confer resistance to beta-lactam antibiotics in Enterobacteriaceae isolated from ready-to-eat vegetables in Mexico City.
Diversity of resistance mechanisms in carbapenem-resistant Enterobacteriaceae at a health care system in Northern California, from 2013 to 2016.
The study identified various carbapenemase genes, including bla OXA-48 like, bla KPC, bla NDM, bla SME, bla IMP, and bla VIM, contributing to carbapenem resistance in Enterobacteriaceae isolates. These genes were found in different bacterial species, and their presence influenced the susceptibility profiles of the isolates to newer β-lactam/β-lactamase inhibitors.
Complete Genome Sequence of bla (IMP-6)-Positive Metakosakonia sp. MRY16-398 Isolate From the Ascites of a Diverticulitis Patient.
The study identifies the blaIMP-6 gene, along with aacA4'-3, aadA2, and tet(A), as responsible for carbapenem and aminoglycoside resistance in the novel Metakosakonia sp. strain MRY16-398.
The plasmid-encoded transcription factor ArdK contributes to the repression of the IMP-6 metallo-β-lactamase gene blaIMP-6, leading to a carbapenem-susceptible phenotype in the blaIMP-6-positive Escherichia coli strain A56-1S.
Molecular Epidemiology of Emerging Carbapenem Resistance in Acinetobacter nosocomialis and Acinetobacter pittii in Taiwan, 2010 to 2014.
The study identified blaOXA-72, blaOXA-58, blaOXA-23, blaIMP-1, and blaOXA-272-like as key carbapenem resistance genes in Acinetobacter nosocomialis and Acinetobacter pittii, highlighting their role in the increasing prevalence of carbapenem resistance in these species.
Molecular Characterization of Carbapenem Resistant Klebsiella pneumoniae and Klebsiella quasipneumoniae Isolated from Lebanon.
The study identified several carbapenemase genes, including bla OXA-48, bla NDM-1, bla NDM-7, and bla CTX-M-15, as well as the chromosomally-encoded beta-lactamase bla OKP-B-3, in carbapenem-resistant Klebsiella pneumoniae and Klebsiella quasipneumoniae isolates from Lebanon.
Sequencing and Genomic Diversity Analysis of IncHI5 Plasmids.
The study identified carbapenemase genes blaIMP-4, blaIMP-38, and blaVIM-1 within ARI-A and ARI-B islands of IncHI5 plasmids, contributing to carbapenem resistance in Klebsiella pneumoniae and other bacteria.
Sequencing and Genomic Diversity Analysis of IncHI5 Plasmids.
The study identified carbapenemase genes blaIMP-4, blaIMP-38, and blaVIM-1 within ARI-A and ARI-B islands of IncHI5 plasmids, contributing to carbapenem resistance in Klebsiella pneumoniae and other bacteria.
Genetic Diversity of Carbapenem-Resistant Enterobacteriaceae (CRE) Clinical Isolates From a Tertiary Hospital in Eastern China.
The study identified multiple carbapenemase genes (blaKPC-2, blaKPC-3, blaNDM-1, blaNDM-5, blaIMP-4, and blaVIM-1) and porin gene mutations (ompK35, ompK36, and ompF) contributing to carbapenem resistance in CRE isolates from a Chinese hospital.
Synergistic Effect of Ceftazidime-Avibactam with Meropenem against Panresistant, Carbapenemase-Harboring Acinetobacter baumannii and Serratia marcescens Investigated Using Time-Kill and Disk Approximation Assays.
The study investigated the synergistic effects of ceftazidime-avibactam with meropenem against panresistant, carbapenemase-harboring Acinetobacter baumannii and Serratia marcescens. It found that ceftazidime-avibactam was effective against S. marcescens isolates carrying bla KPC-2, while synergy with meropenem was observed in some A. baumannii isolates co-harboring bla OXA-23 and bla OXA-117.
High Burden of Extended-Spectrum beta-lactamase-Producing Escherichia coli and Klebsiella pneumoniae Bacteremia in Older Adults: A Seven-Year Study in Two Rural Thai Provinces.
The study identified the presence of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae in two rural Thai provinces, highlighting the increasing prevalence of these resistant strains and their association with higher mortality rates and reduced susceptibility to various antibiotics.
Transcriptome analysis of beta-lactamase genes in diarrheagenic Escherichia coli.
Identification of Diverse Integron and Plasmid Structures Carrying a Novel Carbapenemase Among Pseudomonas Species.
The study identifies a novel carbapenemase, IMP-63, in Pseudomonas aeruginosa and Pseudomonas putida strains, highlighting its role in carbapenem resistance and its presence in diverse integron and plasmid structures.
Hospital effluent: A reservoir for carbapenemase-producing Enterobacterales?
The study identified carbapenemase-producing Enterobacterales (CPE) in hospital effluent and municipal wastewater, with blaOXA-48, blaKPC, blaVIM, and blaIMP detected in hospital and post-hospital wastewater samples. blaNDM was found in pre-hospital wastewater.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
Active Surveillance of Carbapenemase-Producing Organisms (CPO) Colonization With Xpert Carba-R Assay Plus Positive Patient Isolation Proves to Be Effective in CPO Containment.
The study identified KPC, NDM, and IMP carbapenemase genes in CPO-colonized patients using the Xpert Carba-R assay, demonstrating its effectiveness in detecting carbapenemase-producing organisms and aiding in infection control through patient isolation.
Rapid detection and molecular survey of blaVIM, blaIMP and blaNDM genes among clinical isolates of Acinetobacter baumannii using new multiplex real-time PCR and melting curve analysis.
The study developed a multiplex real-time PCR assay for detecting blaIMP, blaVIM, and blaNDM genes in Acinetobacter baumannii clinical isolates, showing 100% concordance with conventional PCR. blaVIM was the most prevalent MBL gene, while blaNDM was not detected.
Evaluation of the Synergy of Ceftazidime-Avibactam in Combination with Meropenem, Amikacin, Aztreonam, Colistin, or Fosfomycin against Well-Characterized Multidrug-Resistant Klebsiella pneumoniae and Pseudomonas aeruginosa.
The study evaluated the synergy of ceftazidime-avibactam (CZA) in combination with other antibiotics against multidrug-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa. Several AMR genes, including blaKPC-2, blaKPC-3, blaCTX-M-15, and others, were identified as conferring resistance to CZA and other antibiotics.
Laboratory and Clinical Evaluation of DNA Microarray for the Detection of Carbapenemase Genes in Gram-Negative Bacteria from Hospitalized Patients.
The study developed a DNA microarray for the detection of eight carbapenemase genes (blaKPC, blaNDM-1, blaOXA-23, blaOXA-48, blaOXA-51, blaIMP, blaVIM, and blaDIM) in Gram-negative bacteria, demonstrating high specificity and sensitivity.
Establishing Antimicrobial Resistance Surveillance & Research Network in India: Journey so far.
The study characterizes various AMR genes and mutations in different bacterial pathogens, highlighting the prevalence of resistance to multiple antibiotics, including beta-lactams, fluoroquinolones, and aminoglycosides. Key findings include the widespread presence of bla OXA-48, bla TEM, and qnrS1 in Enterobacteriaceae, and mecA, mupA, cfr, and ermC in Staphylococcus aureus.
Dissemination of Carbapenem-Resistance among Multidrug Resistant Pseudomonas aeruginosa carrying Metallo-Beta-Lactamase Genes, including the Novel bla(IMP-65) Gene in Thailand.
The study identified the novel IMP-type metallo-beta-lactamase gene blaIMP-65, which confers resistance to carbapenems. It also detected blaIMP-1, blaIMP-13, blaIMP-14a, and blaVIM-2 genes in multidrug-resistant Pseudomonas aeruginosa isolates in Thailand.
Dissemination of Carbapenem-Resistance among Multidrug Resistant Pseudomonas aeruginosa carrying Metallo-Beta-Lactamase Genes, including the Novel bla(IMP-65) Gene in Thailand.
Dissemination of Carbapenem-Resistance among Multidrug Resistant Pseudomonas aeruginosa carrying Metallo-Beta-Lactamase Genes, including the Novel bla(IMP-65) Gene in Thailand.
Performance Evaluation of the MBT STAR(®)-Carba IVD Assay for the Detection of Carbapenemases With MALDI-TOF MS.
The MBT STAR®-Carba IVD assay effectively detects carbapenemase-producing organisms, showing high sensitivity and specificity for various carbapenemase genes including blaOXA-48, blaKPC, blaNDM, blaVIM, blaIMP, blaOXA-23, blaOXA-24/-40, and blaOXA-58.
Identification of a Novel Plasmid Lineage Associated With the Dissemination of Metallo-β-Lactamase Genes Among Pseudomonads.
The study identifies a novel plasmid lineage associated with the dissemination of metallo-beta-lactamase genes among Pseudomonas species, including blaVIM-1, blaVIM-2, blaIMP-63, and blaBIM.
Imipenemase-producing carbapenem-resistant Enterobacteriaceae transmission in a long-term-care facility during a community-wide multidrug resistant organism outbreak-North Carolina, 2017.
The study identified IMP-producing carbapenem-resistant Enterobacteriaceae (CRE) in a long-term-care facility during a community-wide outbreak of extended-spectrum beta-lactamase (ESBL)-producing organisms. The IMP gene was detected in carbapenem-resistant Providencia rettgeri, highlighting the emergence of a novel carbapenemase in North Carolina.
High frequency of the exoU+/exoS+ genotype associated with multidrug-resistant "high-risk clones" of Pseudomonas aeruginosa clinical isolates from Peruvian hospitals.
The exoU gene was associated with increased resistance to fluoroquinolones and aminoglycosides in Pseudomonas aeruginosa isolates.
Diagnostic performance of the Xpert Carba-R assay for active surveillance of rectal carbapenemase-producing organisms in intensive care unit patients.
The study evaluated the diagnostic performance of the Xpert Carba-R assay for detecting rectal carbapenemase-producing organisms (CPOs) in ICU patients, identifying bla KPC, bla NDM, bla VIM, bla IMP-1, and bla OXA-48 as the main carbapenemase genes associated with resistance to carbapenems.
Protein determinants of dissemination and host specificity of metallo-β-lactamases.
The study identifies blaNDM-1, blaVIM-2, and blaSPM-1 as metallo-beta-lactamase genes that confer resistance to carbapenems. The expression of these genes in different bacterial hosts leads to varying fitness costs, influencing their dissemination and host specificity.
High Prevalence of Metallo-β-Lactamase-Producing Enterobacter cloacae From Three Tertiary Hospitals in China.
The study identified multiple metallo-beta-lactamase genes, including blaNDM-1, blaIMP-26, blaIMP-4, blaIMP-1, blaVIM-4, and blaKPC-2, as major contributors to carbapenem resistance in Enterobacter cloacae isolates from three hospitals in China.
High Prevalence of Metallo-β-Lactamase-Producing Enterobacter cloacae From Three Tertiary Hospitals in China.
The study identified multiple metallo-beta-lactamase genes, including blaNDM-1, blaIMP-26, blaIMP-4, blaIMP-1, blaVIM-4, and blaKPC-2, as major contributors to carbapenem resistance in Enterobacter cloacae isolates from three hospitals in China.
High Prevalence of Metallo-β-Lactamase-Producing Enterobacter cloacae From Three Tertiary Hospitals in China.
The study identified multiple metallo-beta-lactamase genes, including blaNDM-1, blaIMP-26, blaIMP-4, blaIMP-1, blaVIM-4, and blaKPC-2, as major contributors to carbapenem resistance in Enterobacter cloacae isolates from three hospitals in China.
Detection of VIM-1, VIM-2 and IMP-1 metallo- β-lactamase genes in Klebsiella pneumoniae isolated from clinical samples in Sanandaj, Kurdistan, west of Iran.
The study identified the presence of blaVIM-1 and blaIMP-1 genes in K. pneumoniae isolates, indicating resistance to carbapenems. VIM-1 was more prevalent than IMP-1.
Phenotypic and genotypic detection of metallo-β-lactamases in A. baumanii isolates obtained from clinical samples in Shahrekord, southwest Iran.
The study identified the presence of bla(VIM-1) and bla(IMP-1) genes in Acinetobacter baumannii isolates, which confer resistance to meropenem and imipenem.
Occurrence of beta-lactamase-Producing Gram-Negative Bacterial Isolates in Water Sources in Cali City, Colombia.
The study identified several beta-lactamase genes, including bla TEM-1, bla CTX-M-9, bla VIM-2, bla IMP-1, and bla AmpC, in Gram-negative bacterial isolates from water sources in Cali, Colombia. These genes conferred resistance to various β-lactam antibiotics, highlighting the presence of antibiotic resistance genes in aquatic environments.
IMP-68, a Novel IMP-Type Metallo-β-Lactamase in Imipenem-Susceptible Klebsiella pneumoniae.
The study identifies a novel IMP-type metallo-beta-lactamase, IMP-68, which exhibits reduced imipenem-hydrolyzing activity compared to other carbapenems, leading to imipenem susceptibility despite carbapenem resistance.
IMP-68, a Novel IMP-Type Metallo-β-Lactamase in Imipenem-Susceptible Klebsiella pneumoniae.
IMP-68, a Novel IMP-Type Metallo-β-Lactamase in Imipenem-Susceptible Klebsiella pneumoniae.
IMP-68, a Novel IMP-Type Metallo-β-Lactamase in Imipenem-Susceptible Klebsiella pneumoniae.
IMP-68, a Novel IMP-Type Metallo-β-Lactamase in Imipenem-Susceptible Klebsiella pneumoniae.
Bactericidal efficacy of meropenem in combination with cefmetazole against IMP-producing carbapenem-resistant Enterobacteriaceae.
The study demonstrates that the combination of meropenem and cefmetazole shows synergistic activity against IMP-producing carbapenem-resistant Enterobacteriaceae, with significant reductions in MIC values and bactericidal effects observed in time-killing assays.
Bactericidal efficacy of meropenem in combination with cefmetazole against IMP-producing carbapenem-resistant Enterobacteriaceae.
The study demonstrates that the combination of meropenem and cefmetazole shows synergistic activity against IMP-producing carbapenem-resistant Enterobacteriaceae, with significant reductions in MIC values and bactericidal effects observed in time-killing assays.
Mutation S115T in IMP-Type Metallo-β-Lactamases Compensates for Decreased Expression Levels Caused by Mutation S119G.
The study shows that the combination of S115T and S119G mutations in IMP-type metallo-beta-lactamases enhances enzyme activity and thermal stability, while the individual mutations have varying effects on expression and stability.
High-Risk International Clones of Carbapenem-Nonsusceptible Pseudomonas aeruginosa Endemic to Indonesian Intensive Care Units: Impact of a Multifaceted Infection Control Intervention Analyzed at the Genomic Level.
The study identified several carbapenemase-encoding genes (blaGES-5, blaIMP-1, blaIMP-7, blaIMP-43, blaVIM-2, and blaVIM-8) and mutations in the porin gene oprD that contribute to carbapenem resistance in Pseudomonas aeruginosa isolates from Indonesian ICUs.
High-Risk International Clones of Carbapenem-Nonsusceptible Pseudomonas aeruginosa Endemic to Indonesian Intensive Care Units: Impact of a Multifaceted Infection Control Intervention Analyzed at the Genomic Level.
The study identified several carbapenemase-encoding genes (blaGES-5, blaIMP-1, blaIMP-7, blaIMP-43, blaVIM-2, and blaVIM-8) and mutations in the porin gene oprD that contribute to carbapenem resistance in Pseudomonas aeruginosa isolates from Indonesian ICUs.
High-Risk International Clones of Carbapenem-Nonsusceptible Pseudomonas aeruginosa Endemic to Indonesian Intensive Care Units: Impact of a Multifaceted Infection Control Intervention Analyzed at the Genomic Level.
The study identified several carbapenemase-encoding genes (blaGES-5, blaIMP-1, blaIMP-7, blaIMP-43, blaVIM-2, and blaVIM-8) and mutations in the porin gene oprD that contribute to carbapenem resistance in Pseudomonas aeruginosa isolates from Indonesian ICUs.
Treatment Options for Carbapenem-resistant Gram-negative Bacterial Infections.
The paper discusses various carbapenem-resistant gram-negative pathogens and highlights the importance of new antimicrobial agents like ceftazidime-avibactam, meropenem-vaborbactam, and others in treating infections caused by these resistant organisms.
First Report of Coexistence of Three Different MDR Plasmids, and That of Occurrence of IMP-Encoding Plasmid in Leclercia adecarboxylata.
The study reports the first identification of three different multidrug-resistant (MDR) plasmids in a single clinical isolate of Leclercia adecarboxylata, including the blaIMP-8 gene encoded on an IMP-encoding plasmid. These plasmids harbor various AMR genes such as blaIMP-8, aacC2, aadA2, mph(A), sul1, qacED1, mer, chrA, dfrA12, tmrB, catA1, catB8, tet(C), blaCTX-M-9, and blaTEM-1.
The Rapid Carbapenemase Detection Method (rCDM) for Rapid and Accurate Detection of Carbapenemase-Producing Enterobacteriaceae and Pseudomonas aeruginosa.
The study developed the rapid carbapenemase detection method (rCDM) for detecting carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa. The method showed high sensitivity and specificity for detecting various carbapenemase genes, including blaKPC-2, blaIMP-4, blaVIM-1, blaNDM-1, blaOXA-48, and blaVIM-4.
Type 1, 2, and 1/2-Hybrid IncC Plasmids From China.
The study identifies several beta-lactamase genes (bla CMY-6, bla CTX-M-3, bla CTX-M-14, bla IMP-8, bla NDM-1) and a sulfonamide resistance gene (sul2) in various IncC plasmids from China. These genes confer resistance to multiple antibiotics, including cephalosporins, carbapenems, and sulfonamides.
Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units.
The study evaluated the FilmArray PP for detecting respiratory pathogens and resistance genes in ICU patients, identifying bla CTX-M, bla IMP, bla NDM, and bla VIM as the main resistance genes.
Leclercia adecarboxylata From Human Gut Flora Carries mcr-4.3 and bla (IMP-4)-Bearing Plasmids.
The study identifies the presence of mcr-4.3 and blaIMP-4 genes in a Leclercia adecarboxylata strain, highlighting the potential for gut flora to act as a reservoir for antibiotic resistance genes.
The Occurrence and Characterization of Extended-Spectrum-Beta-Lactamase-Producing Escherichia coli Isolated from Clinical Diagnostic Specimens of Equine Origin.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including a novel TEM-1-type gene, bla TEM-233, in Escherichia coli isolates from equine clinical specimens. It also detected bla SHV-12, bla CTX-M-1, bla OXA-1, and bla IMP-1, highlighting the presence of multidrug-resistant E. coli in equine populations.
Molecular surveillance of carbapenemase-producing Pseudomonas aeruginosa at three medical centres in Cologne, Germany.
The study identified various carbapenemase genes including bla VIM-1, bla VIM-2, bla IMP-82, bla NDM-1, and bla GES-5 in carbapenem-resistant Pseudomonas aeruginosa isolates from three German medical centers.
Fecal Carriage and Epidemiology of Carbapenem-Resistant Enterobacteriaceae Among Hospitalized Patients in a University Hospital.
The study identified KPC, NDM, and IMP carbapenemases as the primary resistance mechanisms in CRE isolates, with KPC being the most prevalent. No mcr-1 gene was detected in the CRE isolates.
Molecular-diversity, Prevalence and Antibiotic Susceptibility of Pathogenic Klebsiella Pneumoniae under Saudi Condition.
The study identified the SHV-9, CTX-M-15, TEM-1, IMP-4, KPC2, and KPC3 genes as prevalent in Klebsiella pneumoniae isolates in Saudi Arabia, contributing to resistance against multiple antibiotics.
Evaluation of the Revogene Carba C Assay for Detection and Differentiation of Carbapenemase-Producing Gram-Negative Bacteria.
The Revogene Carba C assay effectively detects the five major carbapenemases (NDM, VIM, IMP, KPC, and OXA-48) in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii, demonstrating high sensitivity and specificity.
High quality 3C de novo assembly and annotation of a multidrug resistant ST-111 Pseudomonas aeruginosa genome: Benchmark of hybrid and non-hybrid assemblers.
The study identified the presence of blaVIM-2 and blaIMP-18 genes in the multidrug-resistant Pseudomonas aeruginosa strain AG1, which confer resistance to carbapenems.
Molecular characterization of metallo-β-lactamase- producing carbapenem-resistant Enterobacter cloacae complex isolated in Heilongjiang Province of China.
The study identified multiple carbapenem-resistant Enterobacter cloacae complex (CREC) strains carrying metallo-beta-lactamases blaNDM-1 and blaIMP-4, along with quinolone resistance genes qnrS and aac(6')-Ib-cr. Mutations in gyrA and parC were associated with fluoroquinolone resistance.
High Expression of Metallo-beta-lactamase Contributed to the Resistance to Carbapenem in Clinical Isolates of Pseudomonas aeruginosa from Baotou, China.
The study identified blaSIM, blaIMP, and blaVIM as metallo-beta-lactamase genes contributing to carbapenem resistance in Pseudomonas aeruginosa. Additionally, mutations in oprD2 and overexpression of mexA were also linked to resistance.
Carbapenem-Resistant Enterobacter hormaechei ST1103 with IMP-26 Carbapenemase and ESBL Gene bla (SHV-178).
The study identifies a multidrug-resistant Enterobacter hormaechei strain L51 carrying the bla IMP-26 carbapenemase gene and bla SHV-178 ESBL gene, along with other resistance genes on a conjugative IncHI2/2A plasmid.
Resistome in Lake Bolonha, Brazilian Amazon: Identification of Genes Related to Resistance to Broad-Spectrum Antibiotics.
The study identified several AMR genes in Lake Bolonha, including bla CTX-M, bla SHV, bla TEM, bla VIM, bla IMP, intl1, and intl2, which confer resistance to beta-lactams and other antibiotics. These genes were found in various bacterial isolates, highlighting the presence of multidrug-resistant bacteria in the lake.
Oral colonisation by antimicrobial-resistant Gram-negative bacteria among long-term care facility residents: prevalence, risk factors, and molecular epidemiology.
The study identified several AMR genes in Gram-negative bacteria isolated from LTCF residents, including bla CTX-M-27, bla CTX-M-14, bla TEM-1B, bla IMP-1, and others, which confer resistance to various antibiotics such as β-lactams, aminoglycosides, and fluoroquinolones.
Development of a Two Triplex Real-Time Polymerase Chain Reaction for Rapid Detection of Six Carbapenemase Genes in Enterobacteriaceae.
The study developed a two triplex real-time PCR assay for the rapid detection of six carbapenemase genes (blaKPC, blaNDM, blaOXA-48_like, blaIMP, blaVIM, and blaGES) in Enterobacteriaceae, demonstrating 100% concordance with previously identified genotypes.
Genetics of Acquired Antibiotic Resistance Genes in Proteus spp.
The paper reviews the genetics of acquired antibiotic resistance genes in Proteus spp., focusing on the identification and characterization of various beta-lactamases, including TEM, CTX-M, CMY, KPC, NDM, VEB, and OXA types, as well as aminoglycoside modifying enzymes like aac(6')-Ib and aadB, and quinolone resistance genes like qnrD.
Sulfamoyl Heteroarylcarboxylic Acids as Promising Metallo-β-Lactamase Inhibitors for Controlling Bacterial Carbapenem Resistance.
The study identifies and characterizes the inhibitory activity of sulfamoyl heteroarylcarboxylic acids (SHCs) against metallo-beta-lactamases (MBLs), particularly IMP-1, NDM-1, and VIM-2, which are responsible for carbapenem resistance in Enterobacteriaceae and Acinetobacter spp.
Rapid Detection of KPC-Producing Enterobacterales Susceptible to Imipenem/Relebactam by Using the MALDI-TOF MS MBT STAR-Carba IVD Assay.
The study presents a MALDI-TOF MS-based method for rapidly detecting KPC-producing Enterobacterales susceptible to imipenem/relebactam, showing high sensitivity and specificity.
Prevalence of metallo-β-lactamase-producing Pseudomonas aeruginosa isolated from diabetic foot infections in Iraq.
The study identified bla VIM, bla IMP, bla SPM, bla SIM, and bla NDM genes in MBL-producing P. aeruginosa isolates from diabetic foot infections in Iraq.
Characterization of an IMP-4-Producing Klebsiella pneumoniae ST1873 Strain Recovered from an Infant with a Bloodstream Infection in China.
The study characterizes an IMP-4-producing Klebsiella pneumoniae ST1873 strain, identifying multiple antimicrobial resistance genes including blaIMP-4, blaSHV-2, blaSHV-11, oqxA, oqxB, aph(6)-Id, strA, catA1, dfrA5, sul2, and fosA.
Evaluation of the EDTA-Modified Carbapenem Inactivation Method for Detecting Metallo-β-Lactamase-Producing Pseudomonas aeruginosa.
The study evaluated the EDTA-modified carbapenem inactivation method (eCIM) for detecting metallo-β-lactamase-producing Pseudomonas aeruginosa. It found that eCIM effectively identified VIM, NDM, and GES-producing isolates, but failed to detect IMP and SPM-producing isolates. Modifications to the mCIM improved detection of GES-producing isolates.
Value of multiplex PCR for detection of antimicrobial resistance in samples retrieved from patients with orthopaedic infections.
The study evaluated the performance of multiplex PCR (mPCR) for detecting antimicrobial resistance genes in clinical samples from patients with orthopaedic infections. It identified several resistance genes, including mecA, mecC, aac(6')/aph(2''), ermA, ermC, rpoB, vanA, vanB, ctx-M, blaNDM, blaOXA-23, blaOXA-24, blaOXA-48, blaOXA-58, blaIMP, blaKPC, gyrA83, gyrA87, and aacA4, which confer resistance to various antibiotics such as oxacillin, aminoglycosides, macrolides/lincosamides, rifampin, vancomycin, third-generation cephalosporins, carbapenems, and fluoroquinolones.
Emergence of carbapenem-resistant and colistin-susceptible Enterobacter cloacae complex co-harboring bla(IMP-1) and mcr-9 in Japan.
The study identifies bla(IMP-1) and mcr-9 in carbapenem-resistant and colistin-susceptible Enterobacter cloacae complex isolates in Japan, highlighting the coexistence of these resistance mechanisms.
Complete-Genome Sequencing and Comparative Genomic Characterization of an IMP-4 Producing Citrobacter freundii Isolate from Patient with Diarrhea.
The study identified the blaIMP-4 gene in a carbapenem-resistant Citrobacter freundii isolate, which is located on an IncN1 plasmid and exhibits horizontal transfer capability. Additional resistance genes such as qnrS1, blaCMY-109, and qnr-B38 were also characterized.
Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace.
The paper reviews various carbapenemases in Acinetobacter baumannii, including OXA-23, OXA-24, OXA-51, OXA-58, OXA-143, OXA-235, NDM-1, VIM-1, VIM-2, IMP-1, IMP-2, IMP-4, and IMP-5, highlighting their roles in carbapenem resistance.
Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace.
The paper reviews various carbapenemases in Acinetobacter baumannii, including OXA-23, OXA-24, OXA-51, OXA-58, OXA-143, OXA-235, NDM-1, VIM-1, VIM-2, IMP-1, IMP-2, IMP-4, and IMP-5, highlighting their roles in carbapenem resistance.
Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace.
The paper reviews various carbapenemases in Acinetobacter baumannii, including OXA-23, OXA-24, OXA-51, OXA-58, OXA-143, OXA-235, NDM-1, VIM-1, VIM-2, IMP-1, IMP-2, IMP-4, and IMP-5, highlighting their roles in carbapenem resistance.
Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace.
The paper reviews various carbapenemases in Acinetobacter baumannii, including OXA-23, OXA-24, OXA-51, OXA-58, OXA-143, OXA-235, NDM-1, VIM-1, VIM-2, IMP-1, IMP-2, IMP-4, and IMP-5, highlighting their roles in carbapenem resistance.
Multicenter Evaluation of the Xpert Carba-R Assay for Detection and Identification of Carbapenemase Genes in Sputum Specimens.
The Xpert Carba-R assay effectively detects carbapenemase genes (bla KPC, bla NDM, bla IMP, and bla VIM) in sputum specimens, providing rapid and accurate identification of carbapenem-resistant Enterobacteriaceae.
Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria.
The study demonstrates the development of CRISPR-Cas13a-based antimicrobials that can specifically kill bacteria carrying AMR genes such as blaIMP-1, mcr-1, mcr-2, blaOXA-48, blaVIM-2, blaNDM-1, blaKPC-2, and mecA.
Molecular Characteristics of Carbapenem-Resistant Enterobacter cloacae in a Tertiary Hospital in China.
The study identified four types of carbapenemases (IMP-26, NDM-5, NDM-1, and KPC-2) in 12 carbapenem-resistant Enterobacter cloacae strains, along with CTX-M-3 and DHA1 beta-lactamases.
AcGI1, a novel genomic island carrying antibiotic resistance integron In687 in multidrug resistant Achromobacter xylosoxidans in a teaching hospital in Thailand.
The study identifies a novel genomic island, AcGI1, carrying the carbapenem resistance gene blaIMP-14a and other resistance genes in multidrug-resistant Achromobacter xylosoxidans strains from Thailand.
IMP-38-Producing High-Risk Sequence Type 307 Klebsiella pneumoniae Strains from a Neonatal Unit in China.
The study identifies IMP-38-producing high-risk ST307 Klebsiella pneumoniae strains in a neonatal unit in China, highlighting the acquisition of diverse antimicrobial resistance genes, including blaIMP-38, blaCTX-M-3, blaSHV-2A, blaSHV-28, blaTEM-1, aacA4, catB3, oqxA, oqxB, and fosA6.
Distribution of Class B and Class A β-Lactamases in Clinical Strains of Pseudomonas aeruginosa: Comparison of Phenotypic Methods and High-Resolution Melting Analysis (HRMA) Assay.
The study identified various β-lactamase genes, including bla SHV, bla TEM, bla KPC, bla IMP, bla VIM, and bla GES, in Pseudomonas aeruginosa isolates using HRMA assay. These genes were associated with resistance to multiple β-lactam antibiotics.
Metallo-ß-lactamases: a review
The paper reviews the characteristics of metallo-beta-lactamases (MBLs), focusing on their structure, function, and role in antibiotic resistance. It highlights the importance of MBLs in clinical settings and discusses various inhibitors that target these enzymes.
Prevalence of plasmid-encoded carbapenemases in multi-drug resistant Escherichia coli from patients with urinary tract infection in northern Iran.
The study identified the presence of plasmid-encoded carbapenemases, including bla IMP, bla VIM, bla KPC, and bla OXA-48, in multi-drug resistant Escherichia coli isolates from patients with urinary tract infections in northern Iran.
Emergence of Carbapenem-Resistant Providencia rettgeri and Providencia stuartii Producing IMP-Type Metallo-beta-lactamase in Japan.
The study identifies blaIMP-70, a variant of IMP-1 metallo-beta-lactamase with two amino acid substitutions (Val67Phe and Phe87Val), as a novel carbapenem-resistance gene in Providencia rettgeri and Providencia stuartii. Additionally, blaIMP-1 and blaIMP-11 were also characterized as carbapenem-resistance genes in these isolates.
Emergence of Carbapenem-Resistant Providencia rettgeri and Providencia stuartii Producing IMP-Type Metallo-beta-lactamase in Japan.
The study identifies blaIMP-70, a variant of IMP-1 metallo-beta-lactamase with two amino acid substitutions (Val67Phe and Phe87Val), as a novel carbapenem-resistance gene in Providencia rettgeri and Providencia stuartii. Additionally, blaIMP-1 and blaIMP-11 were also characterized as carbapenem-resistance genes in these isolates.
Emergence of Carbapenem-Resistant Providencia rettgeri and Providencia stuartii Producing IMP-Type Metallo-beta-lactamase in Japan.
The study identifies blaIMP-70, a variant of IMP-1 metallo-beta-lactamase with two amino acid substitutions (Val67Phe and Phe87Val), as a novel carbapenem-resistance gene in Providencia rettgeri and Providencia stuartii. Additionally, blaIMP-1 and blaIMP-11 were also characterized as carbapenem-resistance genes in these isolates.
Rapid Detection and Characterization of Carbapenemases in Enterobacterales with a New Modified Carbapenem Inactivation Method, mCIMplus.
The study evaluates the mCIMplus test for rapid detection and characterization of carbapenemases in Enterobacterales, demonstrating high sensitivity and specificity for various carbapenemase types including OXA-48-like, NDM, KPC, VIM, GES-5, and IMP-1.
Antibiogram, Prevalence of OXA Carbapenemase Encoding Genes, and RAPD-Genotyping of Multidrug-Resistant Acinetobacter baumannii Incriminated in Hidden Community-Acquired Infections.
The study identified the prevalence of OXA carbapenemase encoding genes, including bla_OXA-23, bla_OXA-24_like, and bla_OXA-58, along with bla_NDM, bla_VIM, and bla_IMP, in multidrug-resistant Acinetobacter baumannii strains from community-acquired infections in Egypt.
In Vitro Activity of Cefiderocol, a Siderophore Cephalosporin, against Multidrug-Resistant Gram-Negative Bacteria.
Cefiderocol shows good in vitro activity against multidrug-resistant Gram-negative bacteria, including those with NDM, VIM, IMP, KPC, OXA-48-like, GES, IMI, SME, VEB, PER, OXA-23, OXA-24/40, OXA-51, and OXA-58 carbapenemases.
The Efficacy of AgNO3 Nanoparticles Alone and Conjugated with Imipenem for Combating Extensively Drug-Resistant Pseudomonas aeruginosa.
The study identified multiple AMR genes including IMP, VIM, OPR, SIM, SPM, GIM, NDM, VEB, PER, KPC, OXA, intI, intII, intIII, SHV, TEM, and CTXM in extensively drug-resistant Pseudomonas aeruginosa isolates. These genes conferred resistance to various antibiotics, particularly carbapenems and beta-lactams.
Evaluation of the Xpert Carba-R NxG Assay for Detection of Carbapenemase Genes in a Global Challenge Set of Pseudomonas aeruginosa Isolates.
The Xpert Carba-R NxG assay effectively detects various carbapenemase genes, including blaVIM, blaIMP, blaNDM, blaSPM, blaKPC, and blaGES, in Pseudomonas aeruginosa isolates.
Carbapenemase-Producing Gram-Negative Bacteria from American Crows in the United States.
The study identified carbapenemase-producing Gram-negative bacteria in American crows, including Providencia rettgeri with blaIMP-27, Klebsiella pneumoniae with blaKPC-2, and Enterobacter bugandensis with blaIMI-1.
Antibacterial Activity of a Cationic Antimicrobial Peptide against Multidrug-Resistant Gram-Negative Clinical Isolates and Their Potential Molecular Targets.
The study identifies the presence of carbapenemase genes bla KPC, bla NDM, bla VIM, and bla IMP in multidrug-resistant clinical isolates of Klebsiella pneumoniae and Pseudomonas aeruginosa, which confer resistance to carbapenems.
In vitro Synergistic Activity of Antimicrobial Combinations Against bla (KPC) and bla (NDM)-Producing Enterobacterales With bla (IMP) or mcr Genes.
The study evaluated the synergistic effects of various antimicrobial combinations against carbapenemase-producing Enterobacterales, identifying bla KPC, bla NDM, bla IMP, and mcr genes as critical resistance determinants.
Can the use of older-generation beta-lactam antibiotics in livestock production over-select for beta-lactamases of greatest consequence for human medicine? An in vitro experimental model.
The study investigated the selection of beta-lactamases in E. coli strains under different beta-lactam antibiotics, identifying bla TEM-1, bla CMY-2, bla CTX-M-*, and bla KPC/IMP/NDM as conferring resistance to various beta-lactam antibiotics.
Mechanisms of Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa: Results of the GERPA Multicenter Study.
The study identifies multiple mechanisms of resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa, including the production of extended-spectrum beta-lactamases (ESBLs) and carbapenemases, overproduction of the intrinsic cephalosporinase PDC, and mutations in regulatory and peptidoglycan recycling genes.
Emergence of Enterobacter cloacae Complex Co-Producing IMP-10 and CTX-M, and Klebsiella pneumoniae Producing VIM-1 in Clinical Isolates in Japan.
The study reports the emergence of Enterobacter cloacae complex co-producing IMP-10 and CTX-M, and Klebsiella pneumoniae producing VIM-1 in clinical isolates in Japan, highlighting the spread of carbapenemase-producing Enterobacteriaceae.
A Matched Case-Case-Control Study of the Impact of Clinical Outcomes and Risk Factors of Patients with IMP-Type Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae in Japan.
The study identified IMP-11, IMP-1, IMP-60, and IMP-66 as carbapenemases responsible for carbapenem resistance in Enterobacteriaceae, highlighting their role in clinical outcomes and risk factors for IMP-type carbapenemase-producing carbapenem-resistant Enterobacteriaceae (IMP-CRE).
A Matched Case-Case-Control Study of the Impact of Clinical Outcomes and Risk Factors of Patients with IMP-Type Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae in Japan.
The study identified IMP-11, IMP-1, IMP-60, and IMP-66 as carbapenemases responsible for carbapenem resistance in Enterobacteriaceae, highlighting their role in clinical outcomes and risk factors for IMP-type carbapenemase-producing carbapenem-resistant Enterobacteriaceae (IMP-CRE).
A Matched Case-Case-Control Study of the Impact of Clinical Outcomes and Risk Factors of Patients with IMP-Type Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae in Japan.
The study identified IMP-11, IMP-1, IMP-60, and IMP-66 as carbapenemases responsible for carbapenem resistance in Enterobacteriaceae, highlighting their role in clinical outcomes and risk factors for IMP-type carbapenemase-producing carbapenem-resistant Enterobacteriaceae (IMP-CRE).
A Matched Case-Case-Control Study of the Impact of Clinical Outcomes and Risk Factors of Patients with IMP-Type Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae in Japan.
The study identified IMP-11, IMP-1, IMP-60, and IMP-66 as carbapenemases responsible for carbapenem resistance in Enterobacteriaceae, highlighting their role in clinical outcomes and risk factors for IMP-type carbapenemase-producing carbapenem-resistant Enterobacteriaceae (IMP-CRE).
Occurrence, identification, and antibiogram signatures of selected Enterobacteriaceae from Tsomo and Tyhume rivers in the Eastern Cape Province, Republic of South Africa.
The study identified various beta-lactamase genes (bla TEM, bla CTX-M, bla SHV, bla OXA-1-like, bla PER, bla VIM, bla IMP, bla KPC, bla GES, bla OXA-48-like), plasmid-mediated AmpC beta-lactamase genes (bla EBC, bla ACC, bla FOX, bla CIT), tetracycline resistance genes (tetA, tetB, tetD, tetM), chloramphenicol resistance gene (catII), and sulfonamide resistance gene (sulII) in Enterobacteriaceae isolates from Tsomo and Tyhume rivers.
The Novel CarbaLux Test for Carbapenemases and Carbapenem Deactivating AmpC Beta-Lactamases.
The CarbaLux test was developed to rapidly detect carbapenemase-producing bacteria, including various OXA-type carbapenemases (OXA-23, OXA-24/40, OXA-48, OXA-181) and other carbapenemases (KPC, NDM, VIM, IMP-1, OXA-58). It also detects hyper-produced AmpC beta-lactamases, which deactivate carbapenems but are not detectable by previous rapid phenotypic assays.
Naringin inhibits the biofilms of metallo-β-lactamases (MβLs) producing Pseudomonas species isolated from camel meat.
The study identified blaIMP as a metallo-beta-lactamase gene in Pseudomonas spp. isolated from camel meat, which confers resistance to carbapenems.
Carbapenem Use Is Driving the Evolution of Imipenemase 1 Variants.
The study identifies the IMP-78 variant (S262G/V67F) as having the largest changes in MIC values compared to IMP-1, indicating its enhanced resistance to carbapenems. Mutations S262G and V67F in IMP-1-like variants increase resistance to carbapenems but decrease resistance to ampicillin.
Carbapenem Use Is Driving the Evolution of Imipenemase 1 Variants.
The study identifies the IMP-78 variant (S262G/V67F) as having the largest changes in MIC values compared to IMP-1, indicating its enhanced resistance to carbapenems. Mutations S262G and V67F in IMP-1-like variants increase resistance to carbapenems but decrease resistance to ampicillin.
Resistance determinants and their genetic context in enterobacteria from a longitudinal study of pigs reared under various husbandry conditions.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, and bla CMY-2, which confer resistance to various beta-lactam antibiotics in enterobacteria from pigs. Additionally, bla IMP-7 was found to confer resistance to carbapenems in Providencia rettgeri.
First Identification of IMP-1 Metallo-β-Lactamase in Delftia tsuruhatensis Strain CRS1243 Isolated From a Clinical Specimen.
The study reports the first identification of the IMP-1 metallo-β-lactamase in Delftia tsuruhatensis strain CRS1243, highlighting the emergence of this bacterium as a potential cause of opportunistic infections.
Interplay between ESKAPE Pathogens and Immunity in Skin Infections: An Overview of the Major Determinants of Virulence and Antibiotic Resistance.
The paper discusses the major determinants of virulence and antibiotic resistance in ESKAPE pathogens, focusing on genes such as vanA, poxtA, blaZ, mecA, blaKPC-2, blaKPC-3, armA, aacA4, aadA1, acrAB, blaCTX-M, blaGES, blaPER, blaSHV, blaTEM, blaVEB, aac(3')-Ia, ant(2’)-Ia, tetA, tetB, gyrA, parC, pmrC, pmrA, and pmrB, which are associated with resistance to various antibiotics.
Interplay between ESKAPE Pathogens and Immunity in Skin Infections: An Overview of the Major Determinants of Virulence and Antibiotic Resistance.
The paper discusses the major determinants of virulence and antibiotic resistance in ESKAPE pathogens, focusing on genes such as vanA, poxtA, blaZ, mecA, blaKPC-2, blaKPC-3, armA, aacA4, aadA1, acrAB, blaCTX-M, blaGES, blaPER, blaSHV, blaTEM, blaVEB, aac(3')-Ia, ant(2’)-Ia, tetA, tetB, gyrA, parC, pmrC, pmrA, and pmrB, which are associated with resistance to various antibiotics.
Molecular Characterization of Carbapenemase-Producing Klebsiella pneumoniae Isolated from Egyptian Pediatric Cancer Patients Including a Strain with a Rare Gene-Combination of β-Lactamases.
The study identified the presence of multiple carbapenemase genes, including bla OXA-48, bla NDM-1, and bla IMP-1, in carbapenem-resistant Klebsiella pneumoniae isolates from Egyptian pediatric cancer patients. It also reported a rare combination of these genes in one isolate. The study highlights the dissemination of multidrug-resistant clones among hospital wards.
Deskilled and Rapid Drug-Resistant Gene Detection by Centrifugal Force-Assisted Thermal Convection PCR Device.
The study demonstrates a rapid detection method for the blaIMP-6 gene, which confers resistance to carbapenems, using a centrifugal force-assisted thermal convection PCR device. The device successfully detected blaIMP-6 in stool samples within 15 minutes.
An IncP-2 plasmid sublineage associated with dissemination of bla(IMP-45) among carbapenem-resistant Pseudomonas aeruginosa.
The study identifies blaIMP-45 as a metallo-beta-lactamase gene responsible for carbapenem resistance in Pseudomonas aeruginosa, highlighting its dissemination through an IncP-2 plasmid sublineage.
Multinational evaluation of the BioFire® FilmArray® Pneumonia plus Panel as compared to standard of care testing.
The BioFire® FilmArray® Pneumonia plus Panel outperformed standard of care testing in detecting pathogens and antibiotic resistance markers, including bla CTX-M, bla KPC, bla VIM, bla OXA-48-like, and bla IMP genes.
Development of a rapid and sensitive analytical system for Pseudomonas aeruginosa based on reverse transcription quantitative PCR targeting of rRNA molecules.
The study developed a rapid and sensitive RT-qPCR system for detecting Pseudomonas aeruginosa, including drug-resistant strains. It identified the presence of drug resistance genes such as mexA, ampC, and blaIMP in fecal samples of ICU patients.
Prevalence of pathogenic Klebsiella pneumoniae based on PCR capsular typing harbouring carbapenemases encoding genes in Uganda tertiary hospitals.
The study identified various carbapenemase-encoding genes including bla_OXA-48-like, bla_VIM, bla_IMP, bla_KPC, and bla_NDM in Klebsiella pneumoniae isolates from Ugandan tertiary hospitals, highlighting the prevalence of carbapenem resistance.
Institutional outbreak involving multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 at a cancer center in Tokyo, Japan.
The study identified multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 (ST78) strains causing an institutional outbreak. These strains carried blaIMP-1 and blaIMP-11 genes on IncHI2 and IncL/M plasmids, along with various other resistance genes such as aac(6')-IIc, qnrB6, fosA, sul1, and tet(B).
Institutional outbreak involving multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 at a cancer center in Tokyo, Japan.
The study identified multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 (ST78) strains causing an institutional outbreak. These strains carried blaIMP-1 and blaIMP-11 genes on IncHI2 and IncL/M plasmids, along with various other resistance genes such as aac(6')-IIc, qnrB6, fosA, sul1, and tet(B).
Antimicrobial Susceptibility Profiles To Predict the Presence of Carbapenemase Genes among Carbapenem-Resistant Pseudomonas aeruginosa Isolates.
The study identifies bla VIM, bla KPC, bla IMP, and bla NDM as carbapenemase genes associated with carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates. These genes were detected in CRPA isolates and were linked to reduced susceptibility to carbapenems.
Detection of extended spectrum beta-lactamase genes in Pseudomonas aeruginosa isolated from patients in rural Eastern Cape Province, South Africa.
The study identified blaTEM, blaSHV, and blaCTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) resistance in Pseudomonas aeruginosa isolates from the Eastern Cape Province, South Africa. Additionally, blaIMP was detected in a small percentage of isolates.
Emergence of IMP-8-Producing Comamonas thiooxydans Causing Urinary Tract Infection in China.
The study reports the first identification of a blaIMP-8-positive Comamonas thiooxydans strain causing a urinary tract infection in China, highlighting its resistance to multiple antibiotics including aztreonam, fluoroquinolones, and aminoglycosides.
Epidemic HI2 Plasmids Mobilising the Carbapenemase Gene bla(IMP-4) in Australian Clinical Samples Identified in Multiple Sublineages of Escherichia coli ST216 Colonising Silver Gulls.
The study identifies epidemic HI2 plasmids harboring the carbapenemase gene bla(IMP-4) in multiple sublineages of Escherichia coli ST216 isolated from Australian silver gulls, highlighting the role of these plasmids in disseminating antibiotic resistance genes.
Epidemic HI2 Plasmids Mobilising the Carbapenemase Gene bla(IMP-4) in Australian Clinical Samples Identified in Multiple Sublineages of Escherichia coli ST216 Colonising Silver Gulls.
The study identifies epidemic HI2 plasmids harboring the carbapenemase gene bla(IMP-4) in multiple sublineages of Escherichia coli ST216 isolated from Australian silver gulls, highlighting the role of these plasmids in disseminating antibiotic resistance genes.
Acinetobacter baumannii Antibiotic Resistance Mechanisms.
The paper reviews various beta-lactamases and other resistance mechanisms in Acinetobacter baumannii, focusing on their roles in resistance to beta-lactams, aminoglycosides, and other antibiotics.
Acinetobacter baumannii Antibiotic Resistance Mechanisms.
The paper reviews various beta-lactamases and other resistance mechanisms in Acinetobacter baumannii, focusing on their roles in resistance to beta-lactams, aminoglycosides, and other antibiotics.
Acinetobacter baumannii Antibiotic Resistance Mechanisms.
The paper reviews various beta-lactamases and other resistance mechanisms in Acinetobacter baumannii, focusing on their roles in resistance to beta-lactams, aminoglycosides, and other antibiotics.
Acinetobacter baumannii Antibiotic Resistance Mechanisms.
The paper reviews various beta-lactamases and other resistance mechanisms in Acinetobacter baumannii, focusing on their roles in resistance to beta-lactams, aminoglycosides, and other antibiotics.
Metallo-β-lactamase and AmpC genes in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa isolates from abattoir and poultry origin in Nigeria.
The study identified the presence of metallo-beta-lactamase (blaIMP-1, blaIMP-2) and AmpC beta-lactamase (blaCMY, blaFOX) genes in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa isolates from abattoir and poultry origins in Nigeria, indicating the circulation of these resistance genes in the environment.
Metallo-β-lactamase and AmpC genes in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa isolates from abattoir and poultry origin in Nigeria.
The study identified the presence of metallo-beta-lactamase (blaIMP-1, blaIMP-2) and AmpC beta-lactamase (blaCMY, blaFOX) genes in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa isolates from abattoir and poultry origins in Nigeria, indicating the circulation of these resistance genes in the environment.
Metagenome of a polluted river reveals a reservoir of metabolic and antibiotic resistance genes.
The study identified a diverse range of antibiotic resistance genes in the Yamuna River, including metallo-beta-lactamases such as bla NDM-1, bla NDM-8, and others, indicating a significant reservoir of resistance in the river's microbial community.
Metagenome of a polluted river reveals a reservoir of metabolic and antibiotic resistance genes.
The study identified a diverse range of antibiotic resistance genes in the Yamuna River, including metallo-beta-lactamases such as bla NDM-1, bla NDM-8, and others, indicating a significant reservoir of resistance in the river's microbial community.
Screening of Antimicrobial Resistance Genes and Epidemiological Features in Hospital and Community-Associated Carbapenem-Resistant Pseudomonas aeruginosa Infections.
The study identified several carbapenem resistance genes, including blaVEB, blaPER, blaNDM, blaKPC, blaIMP, blaVIM, blaOXA-48, and blaOXA-23, in carbapenem-resistant Pseudomonas aeruginosa isolates.
Carriage of two carbapenem-resistance genes in Pseudomonas aeruginosa isolated from hospital-acquired infections in children from Costa Rica: the importance of local epidemiology.
The study identifies the presence of bla VIM-2 and bla IMP-18 alleles in carbapenem-resistant Pseudomonas aeruginosa isolates from children in Costa Rica, highlighting the need for improved diagnostic methods to detect these resistance genes.
The Direct Semi-Quantitative Detection of 18 Pathogens and Simultaneous Screening for Nine Resistance Genes in Clinical Urine Samples by a High-Throughput Multiplex Genetic Detection System.
The study presents a high-throughput multiplex genetic detection system (UTI-HMGS) capable of semi-quantitative detection of 18 uropathogens and simultaneous screening for nine antibiotic resistance genes directly from clinical urine samples within 4 hours. The system demonstrated high sensitivity and specificity for the detection of uropathogens and resistance genes, with improved detection rates for several important uropathogens compared to conventional culture methods.
Surgical Site Infection Following Caesarean Section by Acinetobacter Species: A Report from a Hyperendemic Setting in the Brazilian Amazon Region.
The study identified carbapenem resistance in Acinetobacter isolates, primarily mediated by bla OXA-23-like and bla OXA-51-like genes in A. baumannii, and bla IMP-1 in A. nosocomialis. These genes conferred resistance to carbapenems.
Evaluation of Xpert Carba-R Assay for the Detection of Carbapenemase Genes in Gram-Negative Bacteria.
The Xpert Carba-R assay demonstrates 100% precision in identifying carbapenemase genes in Gram-negative bacteria, making it an effective tool for early clinical detection.
Carbapenem Resistance Determinants Acquired through Novel Chromosomal Integrations in Extensively Drug-Resistant Pseudomonas aeruginosa.
The study identifies two novel carbapenemase-encoding genomic islands, PAGI-97A and PAGI-97B, harboring bla DIM-1 and bla IMP-1, which contribute to carbapenem resistance in extensively drug-resistant Pseudomonas aeruginosa strains.
Multimodal Interventions to Prevent and Control Carbapenem-Resistant Enterobacteriaceae and Extended-Spectrum β-Lactamase Producer-Associated Infections at a Tertiary Care Hospital in Egypt.
The study identified several carbapenemase genes (bla KPC, bla NDM, bla VIM, bla OXA-48, bla IMP) and extended-spectrum β-lactamase genes (bla CTX-m, bla TEM, bla SHV) in CRE and ESBL-producing isolates, highlighting the prevalence of these resistance mechanisms in a tertiary care hospital in Egypt.
Detection and characterization of carbapenem resistant Gram-negative bacilli isolates recovered from hospitalized patients at Soba University Hospital, Sudan.
The study identified blaNDM as the most prevalent carbapenemase gene among carbapenem-resistant Gram-negative bacilli isolates from Soba University Hospital, Sudan. Other detected carbapenemase genes included blaIMP, blaOXA-48, and blaVIM.
In vitro activity of imipenem/relebactam, meropenem/vaborbactam, ceftazidime/avibactam, cefepime/zidebactam and other novel antibiotics against imipenem-non-susceptible Gram-negative bacilli from Taiwan.
The study evaluated the in vitro activity of several novel antibiotics against imipenem-non-susceptible Gram-negative bacilli, highlighting the effectiveness of β-lactam/BLI-BLE combinations against isolates with various carbapenemase genes.
Emergence of Morganellaceae Harboring bla(IMP-27) Metalloenzyme in Canada.
The study reports the emergence of Morganellaceae harboring the blaIMP-27 gene, a metallo-beta-lactamase, in Canada. The gene was found in various Morganellaceae species and was associated with carbapenem resistance.
Detection of carbapenemase producing enterobacteria using an ion sensitive field effect transistor sensor.
The study evaluated the effectiveness of an ion-sensitive field-effect transistor (ISFET) sensor for detecting carbapenemase-producing enterobacteria. It successfully identified various carbapenemase genes including blaNDM-1, blaVIM-1, blaIMP-1, blaKPC-2, blaNMC-A, and blaOXA-48 in different bacterial strains.
Metallo-beta-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design.
This review discusses the role of metallo-beta-lactamases (MBLs) in multidrug resistance, focusing on their structure, mechanism, and contribution to resistance against β-lactam antibiotics. It highlights the importance of MBLs in the spread of resistance and the challenges they pose for inhibitor design.
One-Step Detection and Classification of Bacterial Carbapenemases in 10 Minutes Using Fluorescence Identification of β-Lactamase Activity.
The study presents a novel assay called FIBA for the rapid detection and classification of bacterial carbapenemases. It identifies various carbapenemase types including KPC, SME, NMC-A, NDM, VIM, IMP, and OXA, demonstrating high sensitivity and specificity.
Enhanced Carbapenem Resistance through Multimerization of Plasmids Carrying Carbapenemase Genes.
The study identifies plasmid multimerization as a novel mechanism enhancing carbapenem resistance through increased copy numbers of the blaIMP-6 gene, leading to elevated carbapenem resistance in Escherichia coli and Klebsiella pneumoniae.
Carbapenem-resistant Enterobacter cloacae complex in a tertiary Hospital in Northeast China, 2010-2019.
The study identified several carbapenemase-encoding genes, including blaNDM-1, blaNDM-5, blaIMP-4, and blaKPC-2, along with various beta-lactamase genes such as TEM-1, CTX-M-15, CTX-M-3, SHV-12, and CTX-M-14, in carbapenem-resistant Enterobacter cloacae complex isolates.
Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn(2+).
Aspergillomarasmine A (AMA) inhibits metallo-β-lactamases (MBLs) by selectively sequestering Zn(2+), thereby reversing carbapenem resistance in bacteria expressing blaNDM-1, blaNDM-6, blaVIM-2, and blaIMP-7.
Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-beta-lactamases.
The study describes novel cephalosporin conjugates that show potent and selective inhibition of imipenemase-type metallo-beta-lactamases (IMP), particularly IMP-1 and IMP-28. These conjugates, notably 8 and 9, demonstrate significant synergy with meropenem, reducing the minimum inhibitory concentration (MIC) against IMP-producing bacteria. The compounds act as slowly turned-over substrates of IMP-28 and their hydrolysis products (8H and 9H) are also potent inhibitors. The study highlights the potential of these conjugates as MBL inhibitors with a focus on IMP-type enzymes.
Dissemination of carbapenem resistance and plasmids encoding carbapenemases in Gram-negative bacteria isolated in India.
The study identifies various carbapenem resistance genes, including blaNDM-1, blaOXA-181, blaGES-1, blaGES-9, blaOXA-23, blaOXA-51, and blaIMP-1, in Gram-negative bacteria from India. These genes were found to confer resistance to meropenem and imipenem.
Practical Agar-Based Disk Diffusion Tests Using Sulfamoyl Heteroarylcarboxylic Acids for Identification of Subclass B1 Metallo-beta-lactamase-Producing Enterobacterales.
The study developed agar-based disk diffusion tests using sulfamoyl heteroarylcarboxylic acids (SFC and SPC) to identify subclass B1 metallo-beta-lactamase-producing Enterobacterales. These tests effectively detected resistance conferred by blaIMP-1, blaNDM-1, and blaVIM-2 genes.
QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics.
QPX7728 is a novel beta-lactamase inhibitor with broad-spectrum activity against serine and metallo-beta-lactamases, including Class A, C, D, and B enzymes. It effectively inhibits clinically relevant beta-lactamases such as KPC-2, CTX-M-15, SHV-12, TEM-43, OXA-48, OXA-23, NDM-1, and VIM-1.
Genetic characterization of extended-spectrum beta-lactamase- and carbapenemase-producing Escherichia coli isolated from Egyptian hospitals and environments.
The study identified several beta-lactamase genes, including blaTEM, blaCTX-M15, blaSHV, blaOXA-48, and blaIMP, which confer resistance to various β-lactam antibiotics in Escherichia coli isolates from Egyptian hospitals and environments.
Virulence characterization and clonal analysis of uropathogenic Escherichia coli metallo-beta-lactamase-producing isolates.
The study identified bla NDM, bla IMP-1, bla IMP-2, and bla OXA-48 as the primary resistance genes in carbapenem-resistant UPEC isolates, highlighting their role in metallo-beta-lactamase and carbapenemase production.
Virulence characterization and clonal analysis of uropathogenic Escherichia coli metallo-beta-lactamase-producing isolates.
The study identified bla NDM, bla IMP-1, bla IMP-2, and bla OXA-48 as the primary resistance genes in carbapenem-resistant UPEC isolates, highlighting their role in metallo-beta-lactamase and carbapenemase production.
Molecular study of metallo-β-lactamases and integrons in Acinetobacter baumannii isolates from burn patients.
High prevalence of MBLs genes, especially blaVIM, was identified in MDR A. baumannii isolates. Most of the strains carried class 1 integrons, and gene cassettes arrays including cmlA5 and cmlA7 were detected for the first time in A. baumannii strains in Iran.
Genomic characterization of carbapenem-non-susceptible Pseudomonas aeruginosa in Singapore.
The study identified multiple carbapenemase genes (blaIMP, blaNDM-1, blaVIM, blaGES-5, blaKPC-2) and chromosomal mutations (ampD, ampR, dacB, mexZ, armZ, nalD, oprD, gyrA, parC) associated with carbapenem resistance in Pseudomonas aeruginosa isolates from Singapore.
Carbapenem-Resistant Klebsiella pneumoniae in Southwest China: Molecular Characteristics and Risk Factors Caused by KPC and NDM Producers.
The study identified bla KPC-2, bla NDM-1, bla NDM-5, and bla IMP-4 as the main carbapenemase genes in CRKP isolates, highlighting their role in carbapenem resistance and the emergence of novel clones like ST4495.
Multiplex lateral flow immunochromatographic assay is an effective method to detect carbapenemases without risk of OXA-48-like cross reactivity.
The study evaluates the NG-Test® CARBA 5 assay for detecting carbapenemases in Enterobacterales, showing high sensitivity and specificity. It identifies bla KPC, bla OXA-48-like, bla NDM, bla VIM, bla IMP, bla IMI, and bla SME as the main carbapenemase genes detected.
Virulence and Antibiotic Resistance Characteristics of Vibrio Isolates From Rustic Environmental Freshwaters.
The study identified several antibiotic resistance genes in Vibrio isolates from environmental freshwater sources, including aadA, strA, aphA1, catII, ampC, blaTEM, blaGES, blaOXA-48, blaIMP, blaVIM, blaKPC, and qnrVC, indicating a significant risk of antimicrobial resistance in these bacteria.
Antibiotic Resistance Genes Among Carbapenem-resistant Enterobacterales (CRE) Isolates of Prapokklao Hospital, Chanthaburi Province, Thailand.
The study identified a high prevalence of carbapenem-resistant Enterobacterales (CRE) carrying multiple carbapenemase genes, including bla NDM, bla IMP, and bla OXA-48-like. These genes confer resistance to carbapenems, and their coexistence in many isolates highlights the complexity of resistance mechanisms.
Genetic characterization of Carbapenem-Resistant Escherichia coli from China, 2015-2017.
The study identified various carbapenemase genes, including NDM-1, NDM-4, NDM-5, NDM-6, NDM-9, KPC-2, IMP-4, and OXA-48, in carbapenem-resistant Escherichia coli isolates from China. ST167 was the most common sequence type, followed by ST410 and ST131.
Prevalence of multidrug-resistance and bla (VIM) and bla (IMP) genes among gram-negative clinical isolates in tertiary care hospital, Kathmandu, Nepal.
The study identified the prevalence of bla(VIM) and bla(IMP) genes among multidrug-resistant gram-negative clinical isolates in a tertiary care hospital in Kathmandu, Nepal.
Genomic surveillance of Pseudomonas aeruginosa in the Philippines, 2013-2014.
The study identified several AMR genes and mutations in Pseudomonas aeruginosa isolates from the Philippines, including bla VIM-2, bla VIM-6, bla NDM-1, bla IMP-26, aac(6')-Ib, aac(6')-Ib4, aac(6')-IIa, aac(6')-31, ant(2")-Ia, aadA1, acc(6')-Ib, qnrVC, gyrA, parC, oprD, nalC, and nalD. These genes and mutations were associated with resistance to carbapenems, aminoglycosides, and fluoroquinolones.
High prevalence of multidrug-resistant non-fermentative Gram-negative bacilli harboring bla (IMP-1) and bla (VIM-1) metallo-beta-lactamase genes in Birjand, south-east Iran.
The study identified blaIMP-1 and blaVIM-1 metallo-beta-lactamase genes in multidrug-resistant non-fermentative Gram-negative bacilli, particularly in Acinetobacter baumannii and Pseudomonas aeruginosa, highlighting the significance of these genes in carbapenem resistance.
Detection and Characterization of Targeted Carbapenem-Resistant Health Care-Associated Threats: Findings from the Antibiotic Resistance Laboratory Network, 2017 to 2019.
The study identified the prevalence of targeted carbapenemase genes (bla KPC, bla NDM, bla OXA-48-like, bla VIM, and bla IMP) in carbapenem-resistant Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii. bla KPC was the most common gene detected in CRE isolates, while bla VIM was prevalent in CP-CRPA isolates. Regional variations in the frequency of these genes were observed.
Genetic Analysis, Population Structure, and Characterisation of Multidrug-Resistant Klebsiella pneumoniae from the Al-Hofuf Region of Saudi Arabia.
The study characterizes multidrug-resistant Klebsiella pneumoniae isolates from Saudi Arabia, identifying resistance genes including OXA-23, SIM, IMP, TEM, SHV, CTX-M, and various insertion sequences.
Application of a multiplex immunochromatographic assay for rapid identification of carbapenemases in a clinical microbiology laboratory: performance and turn-around-time evaluation of NG-test Carba 5.
The Carba 5 assay effectively identifies five major carbapenemases (KPC, NDM, VIM, IMP, and OXA-48-like) with high sensitivity and specificity, offering a faster turnaround time compared to Xpert Carba-R.
Performance Evaluation of the Gradient Diffusion Strip Method and Disk Diffusion Method for Ceftazidime-Avibactam Against Enterobacterales and Pseudomonas aeruginosa: A Dual-Center Study.
The study evaluated the performance of the gradient diffusion strip method and disk diffusion method for determining susceptibility to ceftazidime-avibactam against Enterobacterales and Pseudomonas aeruginosa. It identified various carbapenemase genes, including bla KPC, bla NDM, bla IMP, and bla VIM, which confer resistance to ceftazidime-avibactam.
Analysis of Carbapenemase-Resistant Genotypes of Highly Virulent Klebsiella pneumoniae and Clinical Infection Characteristics of Different MLST Types.
The study identified KPC, IMP, VIM, and NDM carbapenemase genes in 74 CR-KP strains, with KPC being the most prevalent. ST11 was the dominant MLST type and was associated with higher resistance to carbapenems and poorer patient outcomes.
A transferrable IncL/M plasmid harboring a gene encoding IMP-1 metallo-β-lactamase in clinical isolates of Enterobacteriaceae.
The study identifies a transferrable IncL/M plasmid, pSL264, harboring the blaIMP-1 gene, which confers resistance to carbapenems in clinical isolates of Enterobacteriaceae.
First Report of bla (IMP-4) and bla (SRT-2) Coproducing Serratia marcescens Clinical Isolate in China.
The study reports the first identification of a Serratia marcescens clinical isolate in China that produces both blaIMP-4 and blaSRT-2, along with other resistance genes such as aac(6')-Ic, qnrS1, and tet(41).
Phylogenetically Diverse Escherichia coli Strains from Chicken Co-Harbor Multiple Carbapenemase-Encoding Genes (bla (NDM) -bla (OXA)-blaIMP).
The study identified multiple carbapenemase-encoding genes, including blaNDM, blaOXA, and blaIMP, in carbapenem-resistant E. coli isolates from chicken, highlighting the presence of multidrug-resistant strains in food animals.
Emergence of Tigecycline Nonsusceptible and IMP-4 Carbapenemase-Producing K2-ST65 Hypervirulent Klebsiella pneumoniae in China.
The study reports the emergence of IMP-4 carbapenemase-producing K2-ST65 hypervirulent Klebsiella pneumoniae isolates in China, with one isolate showing tigecycline nonsusceptibility due to a frameshift mutation in the acrR gene.
Prevalence and characterisation of carbapenemase encoding genes in multidrug-resistant Gram-negative bacilli.
The study identified various carbapenemase genes, including bla KPC, bla NDM, bla VIM, bla IMP, and bla OXA-48, in multidrug-resistant Gram-negative bacilli, highlighting their prevalence and contribution to carbapenem resistance.
Geographic Patterns of Carbapenem-Resistant Pseudomonas aeruginosa in the Asia-Pacific Region: Results from the Antimicrobial Testing Leadership and Surveillance (ATLAS) Program, 2015-2019.
The study identified various carbapenemase genes, including blaVIM, blaNDM, blaVEB, blaIMP, blaGES, blaTEM, and blaKPC, in carbapenem-resistant Pseudomonas aeruginosa isolates from the Asia-Pacific region.
Characteristics of Carbapenem-Resistant Gram-Negative Bacilli in Patients with Ventilator-Associated Pneumonia.
The study identified blaNDM, blaVIM, blaSPM, blaIMP, and blaGIM carbapenem resistance genes in carbapenem-resistant Gram-negative bacilli from patients with ventilator-associated pneumonia, with blaNDM being the most prevalent.
Effect of Imipenem and Amikacin Combination against Multi-Drug Resistant Pseudomonas aeruginosa.
The study identified blaIMP and aac(6')-Ib as the primary resistance genes contributing to imipenem and amikacin resistance in Pseudomonas aeruginosa, respectively.
Antibacterial effect of cerium oxide nanoparticle against Pseudomonas aeruginosa.
The study found that cerium oxide nanoparticles (CNPs) and Scaffold@CNPs significantly reduced the expression of the genes shv, kpc, and imp in Pseudomonas aeruginosa, indicating their potential to combat antibiotic resistance.
High Prevalence of Klebsiella pneumoniae Infections in AnHui Province: Clinical Characteristic and Antimicrobial Resistance.
The study identified carbapenemase genes KPC-2, NDM-1, VIM-1, IMP-1, and OXA-48 in hypervirulent Klebsiella pneumoniae isolates, highlighting the high prevalence of carbapenem-resistant strains in Anhui province.
Clonal groups of extended-spectrum beta-lactamase and biofilm producing uropathogenic Escherichia coli in Iran.
The study identified various beta-lactamase genes, including bla TEM, bla CTX-M, bla OXA-1, bla IMP, bla VIM, bla KPC, and bla OXA-48, in biofilm-producing uropathogenic Escherichia coli strains from Iran, highlighting their role in multidrug resistance.
Genetic Characterization and Passage Instability of a Hybrid Plasmid Co-Harboring bla(IMP-4) and bla(NDM-1) Reveal the Contribution of Insertion Sequences During Plasmid Formation and Evolution.
The study characterizes a novel plasmid co-harboring bla(IMP-4) and bla(NDM-1) in Klebsiella michiganensis, demonstrating the role of insertion sequences in plasmid formation and instability.
Comparison of novel rapid diagnostic of blood culture identification and antimicrobial susceptibility testing by Accelerate Pheno system and BioFire FilmArray Blood Culture Identification and BioFire FilmArray Blood Culture Identification 2 panels.
The study evaluated the performance of the Accelerate Pheno system, BioFire FilmArray BCID, and BCID2 panels for rapid blood culture identification and antimicrobial susceptibility testing. It identified several AMR genes including bla KPC, bla NDM, bla OXA-48, bla VIM, bla IMP, mecA, vanA, vanB, mcr-1, and CTX-M, which confer resistance to carbapenems, beta-lactams, glycopeptides, polymyxins, and cephalosporins.
Rapid Detection of bla(KPC), bla(NDM), bla(OXA-48-like) and bla(IMP) Carbapenemases in Enterobacterales Using Recombinase Polymerase Amplification Combined With Lateral Flow Strip.
The study developed a rapid RPA-LFS assay for detecting four major carbapenemase genes (blaKPC, blaNDM, blaOXA-48-like, and blaIMP) in Enterobacterales, demonstrating high specificity and sensitivity.
Selection of AmpC beta-lactamase Variants and Metallo-beta-lactamases Leading to Ceftolozane/Tazobactam and Ceftazidime/Avibactam Resistance during Treatment of MDR/XDR Pseudomonas aeruginosa Infections.
The study identifies several AmpC beta-lactamase variants and metallo-beta-lactamases (VIM-2, IMP-13, IMP-28) that confer resistance to ceftolozane/tazobactam and ceftazidime/avibactam in MDR/XDR Pseudomonas aeruginosa isolates.
Selection of AmpC beta-lactamase Variants and Metallo-beta-lactamases Leading to Ceftolozane/Tazobactam and Ceftazidime/Avibactam Resistance during Treatment of MDR/XDR Pseudomonas aeruginosa Infections.
The study identifies several AmpC beta-lactamase variants and metallo-beta-lactamases (VIM-2, IMP-13, IMP-28) that confer resistance to ceftolozane/tazobactam and ceftazidime/avibactam in MDR/XDR Pseudomonas aeruginosa isolates.
Intra- and Extra-Hospital Dissemination of IMP-22-Producing Klebsiella pneumoniae in Northern Portugal: The Breach of the Hospital Frontier Toward the Community.
The study identifies the blaIMP-22 gene as a significant factor in carbapenem resistance among Klebsiella pneumoniae isolates in northern Portugal, highlighting its role in both hospital and community settings.
Intra- and Extra-Hospital Dissemination of IMP-22-Producing Klebsiella pneumoniae in Northern Portugal: The Breach of the Hospital Frontier Toward the Community.
The study identifies the blaIMP-22 gene as a significant factor in carbapenem resistance among Klebsiella pneumoniae isolates in northern Portugal, highlighting its role in both hospital and community settings.
Using Whole Genome Sequencing to Trace, Control and Characterize a Hospital Infection of IMP-4-Producing Klebsiella pneumoniae ST2253 in a Neonatal Unit in a Tertiary Hospital, China.
The study identified the blaIMP-4 gene as a carbapenemase-encoding gene in IMP-4-producing Klebsiella pneumoniae ST2253 strains isolated from a neonatal unit in a tertiary hospital in China. The gene was found to confer resistance to carbapenems.
Predominance of Acinetobacter spp., Harboring the bla(IMP) Gene, Contaminating the Hospital Environment in a Tertiary Hospital in Mwanza, Tanzania: A Cross-Sectional Laboratory-Based Study.
The study identified the bla(IMP) gene as the predominant carbapenem resistance gene in Acinetobacter spp. isolates from hospital environments in Mwanza, Tanzania.
Epidemiology, Molecular Characteristics, and Virulence Factors of Carbapenem-Resistant Pseudomonas aeruginosa Isolated from Patients with Urinary Tract Infections.
The study identified bla IMP-6 and bla NDM-1 as the primary carbapenemase genes in carbapenem-resistant P. aeruginosa (CRPA) isolates from urinary tract infections, with ST235 and ST773 being the dominant clones.
Emergence and Genomic Characterization of a KPC-2-, NDM-1-, and IMP-4-Producing Klebsiella michiganensis Isolate.
The study identifies a Klebsiella michiganensis isolate producing KPC-2, NDM-1, and IMP-4 carbapenemases, highlighting the emergence of multidrug-resistant strains and the potential for horizontal gene transfer.
Major Bloodstream Infection-Causing Bacterial Pathogens and Their Antimicrobial Resistance in South Korea, 2017-2019: Phase I Report From Kor-GLASS.
The study identified several AMR genes, including bla CTX-M–27, vanA, bla OXA–23, bla KPC, bla NDM–5, bla OXA–181, bla DHA–1, bla CMY–2, and mecA, which contribute to resistance against various antibiotics in bloodstream infection-causing pathogens in South Korea.
Metallo-β Lactamase Producing Non-Fermentative Gram-Negative Bacilli from Various Clinical Isolates in a Tertiary Care Hospital: A Descriptive Cross-sectional Study.
The study identified a high prevalence of metallo-β-lactamase (MBL) producing non-fermentative gram-negative bacilli, particularly Pseudomonas aeruginosa and Acinetobacter baumannii, highlighting the need for routine monitoring of MBL-producing isolates in clinical settings.
Evaluation of the VITEK2 AST-XN17 card for the detection of carbapenemase-producing Enterobacterales in isolates primarily producing metallo β-lactamase.
The study evaluates the effectiveness of the VITEK2 AST-XN17 card in detecting carbapenemase-producing Enterobacterales (CPE) and identifies several carbapenemase genes, including blaIMP-6, blaIMP-1, blaIMP-34, blaGES-4, and others, which confer resistance to carbapenems.
Evaluation of the VITEK2 AST-XN17 card for the detection of carbapenemase-producing Enterobacterales in isolates primarily producing metallo β-lactamase.
The study evaluates the effectiveness of the VITEK2 AST-XN17 card in detecting carbapenemase-producing Enterobacterales (CPE) and identifies several carbapenemase genes, including blaIMP-6, blaIMP-1, blaIMP-34, blaGES-4, and others, which confer resistance to carbapenems.
Evaluation of the VITEK2 AST-XN17 card for the detection of carbapenemase-producing Enterobacterales in isolates primarily producing metallo β-lactamase.
The study evaluates the effectiveness of the VITEK2 AST-XN17 card in detecting carbapenemase-producing Enterobacterales (CPE) and identifies several carbapenemase genes, including blaIMP-6, blaIMP-1, blaIMP-34, blaGES-4, and others, which confer resistance to carbapenems.
Molecular Epidemiology, Risk Factors and Clinical Outcomes of Carbapenem-Nonsusceptible Enterobacter cloacae Complex Infections in a Taiwan University Hospital.
The study identified IMP-8 as the primary carbapenemase responsible for carbapenem resistance in carbapenem-nonsusceptible Enterobacter cloacae complex (CnsECC) isolates. IMP-8 was detected in 41.4% of the isolates and was associated with reduced susceptibility to ertapenem and meropenem.
Activity of imipenem/relebactam on Klebsiella pneumoniae with different mechanisms of imipenem non-susceptibility.
Relebactam restored imipenem susceptibility in K. pneumoniae isolates with bla KPC and AmpC but not in those with MBLs. Impaired porin expression and efflux pump activity contributed to imipenem resistance.
Methodology Establishment and Application of VITEK Mass Spectrometry to Detect Carbapenemase-Producing Klebsiella pneumoniae.
The study established a VITEK MS method for rapid detection of carbapenemase-producing Klebsiella pneumoniae (CPKP), demonstrating the detection of KPC-2, IMP-4, IMP-26, NDM-1, and IMP-4+KPC-2 carbapenemase genes.
Methodology Establishment and Application of VITEK Mass Spectrometry to Detect Carbapenemase-Producing Klebsiella pneumoniae.
The study established a VITEK MS method for rapid detection of carbapenemase-producing Klebsiella pneumoniae (CPKP), demonstrating the detection of KPC-2, IMP-4, IMP-26, NDM-1, and IMP-4+KPC-2 carbapenemase genes.
Phenotypic and Genotypic Characterization of a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae ST17-KL38 Clinical Isolate Harboring the Carbapenemase IMP-4.
The study identified the carbapenemase gene blaIMP-4 and the quinolone resistance gene qnrS1 in the hypervirulent carbapenem-resistant Klebsiella pneumoniae isolate XH210, contributing to its multidrug resistance.
Comparison of the Performance of Phenotypic Methods for the Detection of Carbapenem-Resistant Enterobacteriaceae (CRE) in Clinical Practice.
The study identified several carbapenemase genes, including bla KPC-2, bla NDM-1, bla NDM-4, bla NDM-5, bla IMP-4, bla IMP-8, and bla OXA-23, which are responsible for carbapenem resistance in Enterobacteriaceae. These genes were detected in various bacterial species, and their presence was validated through genetic methods.
Comparison of the Performance of Phenotypic Methods for the Detection of Carbapenem-Resistant Enterobacteriaceae (CRE) in Clinical Practice.
The study identified several carbapenemase genes, including bla KPC-2, bla NDM-1, bla NDM-4, bla NDM-5, bla IMP-4, bla IMP-8, and bla OXA-23, which are responsible for carbapenem resistance in Enterobacteriaceae. These genes were detected in various bacterial species, and their presence was validated through genetic methods.
Predictors and Outcomes of Healthcare-Associated Infections Caused by Carbapenem-Nonsusceptible Enterobacterales: A Parallel Matched Case-Control Study.
The study identified various carbapenemase genes including bla KPC-2, bla OXA-48, bla NDM-5, bla NDM-1, bla OXA-181, bla IMP-4, bla OXA-232, and bla NDM-7 as responsible for carbapenem resistance in Enterobacterales causing healthcare-associated infections in Singapore.
Genomic Epidemiology of Carbapenemase-producing Klebsiella pneumoniae in China.
The study identifies blaKPC, blaNDM, and blaIMP genes as the primary carbapenemase genes in carbapenemase-producing Klebsiella pneumoniae (cpKP) isolates in China, highlighting their association with the spread of CG258 cpKP isolates. It also characterizes specific Inc groups of blaKPC-harboring plasmids that contribute to the resistance and competitive advantage of these isolates.
Genomic Epidemiology of Carbapenemase-producing Klebsiella pneumoniae in China.
The study identifies blaKPC, blaNDM, and blaIMP genes as the primary carbapenemase genes in carbapenemase-producing Klebsiella pneumoniae (cpKP) isolates in China, highlighting their association with the spread of CG258 cpKP isolates. It also characterizes specific Inc groups of blaKPC-harboring plasmids that contribute to the resistance and competitive advantage of these isolates.
Global population structure of the Serratia marcescens complex and identification of hospital-adapted lineages in the complex.
The study identified multiple antimicrobial resistance (AMR) genes and mutations in the Serratia marcescens complex, highlighting the presence of hospital-adapted lineages with a high prevalence of multidrug-resistant (MDR) strains. Key AMR genes include blaCTX-M, blaNDM, blaOXA, qnrS1, tet(A), aac(6')-Ib, mph(A), erm(B), aadA, floR, sul1, and dfrA12, which confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, tetracyclines, aminoglycosides, macrolides, florfenicol, sulfonamides, and trimethoprim.
Emergence of Carbapenem-Resistant ST244, ST292, and ST2446 Pseudomonas aeruginosa Clones in Burn Patients in Yunnan Province.
Emergence of Carbapenem-Resistant ST244, ST292, and ST2446 Pseudomonas aeruginosa Clones in Burn Patients in Yunnan Province.
IncFIB-4.1 and IncFIB-4.2 Single-Replicon Plasmids: Small Backbones with Large Accessory Regions.
The study characterizes several AMR genes and mutations in IncFIB-4.1 and IncFIB-4.2 plasmids, highlighting their role in conferring resistance to various antibiotics.
Clonal spread of carbapenemase-producing Enterobacterales in a region, China.
The study identified blaKPC-2 and blaNDM as the most prevalent carbapenemase genes in carbapenem-resistant Enterobacterales (CRE) isolates, with blaKPC-2 being dominant in Klebsiella pneumoniae and blaNDM in various species. The clonal spread of ST11 KPC-2 Klebsiella pneumoniae was highlighted as a key contributor to the rise in CRE in the region.
Inter-species geographic signatures for tracing horizontal gene transfer and long-term persistence of carbapenem resistance.
The study characterizes various carbapenem resistance genes such as blaKPC, blaNDM, blaOXA-48, blaVIM, blaIMP, blaGES, blaSIM, blaTEM, blaSHV, blaCTX-M, ampC, mecA, vanA, vanB, vanC, mcr-1, mcr-2, mcr-3, mcr-4, and mcr-5 in Enterobacterales and other bacterial species, highlighting their role in carbapenem resistance and horizontal gene transfer.
Inter-species geographic signatures for tracing horizontal gene transfer and long-term persistence of carbapenem resistance.
The study characterizes various carbapenem resistance genes such as blaKPC, blaNDM, blaOXA-48, blaVIM, blaIMP, blaGES, blaSIM, blaTEM, blaSHV, blaCTX-M, ampC, mecA, vanA, vanB, vanC, mcr-1, mcr-2, mcr-3, mcr-4, and mcr-5 in Enterobacterales and other bacterial species, highlighting their role in carbapenem resistance and horizontal gene transfer.
Large-Scale Genomic Epidemiology of Klebsiella pneumoniae Identified Clone Divergence with Hypervirulent Plus Antimicrobial-Resistant Characteristics Causing Within-Ward Strain Transmissions.
The study identified clone divergence in Klebsiella pneumoniae, particularly highlighting the emergence of hypervirulent plus antimicrobial-resistant (hv+AMR) subclones. Key AMR genes such as bla KPC-2, bla CTX-M-65, and others were characterized, along with virulence factors like rmpA, rmpA2, and ybt.
Epidemiology of Klebsiella michiganensis Carrying Multidrug-Resistant IncHI5 Plasmids in the Southeast Coastal Area of China.
The study identified multiple AMR genes on IncHI5 plasmids in Klebsiella michiganensis, including beta-lactamases (blaCTX-M-3, blaTEM-1, blaSHV-12, blaIMP-4, blaNDM-1, blaOXA-1, blaOXA-16, blaSFO-1, blaSIM-1), aminoglycoside modifying enzymes (aacA4, arr3, aadA5, gcu37, dfrA1), chloramphenicol acetyltransferase (catA2), streptomycin resistance genes (strA, strB), macrolide resistance genes (msrAB, mph(A)), and quaternary ammonium compound resistance gene (qacG2).
Companion Animals-An Overlooked and Misdiagnosed Reservoir of Carbapenem Resistance.
The paper reviews the prevalence of carbapenemase-producing bacteria in companion animals, highlighting the presence of various carbapenemase genes such as blaIMP-4, blaVIM-1, blaVIM-2, blaNDM-1, blaNDM-5, blaOXA-48, blaOXA-181, and blaOXA-23, which confer resistance to carbapenem antibiotics.
β-Lactam Antibiotics and beta-lactamase Enzymes Inhibitors, Part 2: Our Limited Resources.
The paper reviews β-lactam antibiotics and beta-lactamase enzymes inhibitors, focusing on the mechanisms of resistance mediated by beta-lactamases such as TEM-1, SHV-1, KPC-2, OXA-48, and NDM-1, and highlights the need for new inhibitors to combat carbapenem-resistant bacteria.
Biofilm and Gene Expression Characteristics of the Carbapenem-Resistant Enterobacterales, Escherichia coli IMP, and Klebsiella pneumoniae NDM-1 Associated with Common Bacterial Infections.
The study identified and characterized several AMR genes, including blaIMP, blaNDM-1, marA, ramA, csgA, mqsR, bssS, fimH, luxS, tnaA, intl, soxS, evgA, entB, and ycfM, which are associated with biofilm formation and antibiotic resistance in E. coli IMP and K. pneumoniae NDM-1.
Urban Wildlife Crisis: Australian Silver Gull Is a Bystander Host to Widespread Clinical Antibiotic Resistance.
The study identifies multiple antibiotic resistance genes, including bla_IMP-4, bla_SHV-12, sul1, sul2, mphA, and floR, in Escherichia coli isolates from Australian silver gulls, highlighting the role of wildlife in the spread of clinical antibiotic resistance.
Genetic Characterization of Four Groups of Chromosome-Borne Accessory Genetic Elements Carrying Drug Resistance Genes in Providencia.
This study characterizes four groups of chromosome-borne accessory genetic elements (AGEs) in Providencia, highlighting the diversity and complexity of multidrug resistance (MDR) regions within these elements. It identifies numerous drug resistance genes, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and others, contributing to the understanding of AMR mechanisms in Providencia.
Virulence-associated genes analysis of carbapenemase-producing Escherichia coli isolates.
The study identified bla OXA-48, bla IMP, and bla NDM as the main carbapenemase genes in carbapenem-resistant E. coli isolates, with bla OXA-48 being the most prevalent.
Molecular Mechanism of the β-Lactamase Mediated β-Lactam Antibiotic Resistance of Pseudomonas aeruginosa Isolated From a Chinese Teaching Hospital.
The study identified several β-lactamase genes, including bla_IMP-45, bla_OXA-1, bla_PDC-3, and bla_CARB-3, which contribute to β-lactam antibiotic resistance in Pseudomonas aeruginosa isolates. These genes were found to be transferable via plasmids and conferred resistance to various β-lactam antibiotics.
Molecular Mechanism of the β-Lactamase Mediated β-Lactam Antibiotic Resistance of Pseudomonas aeruginosa Isolated From a Chinese Teaching Hospital.
The study identified several β-lactamase genes, including bla_IMP-45, bla_OXA-1, bla_PDC-3, and bla_CARB-3, which contribute to β-lactam antibiotic resistance in Pseudomonas aeruginosa isolates. These genes were found to be transferable via plasmids and conferred resistance to various β-lactam antibiotics.
Verification and application of a modified carbapenem inactivation method (mCIM) on Pseudomonas aeruginosa: a potential screening methodology on carbapenemases phenotype in Bacillus cereus.
The study verified the modified carbapenem inactivation method (mCIM) for detecting carbapenemase-producing Pseudomonas aeruginosa. It identified IMP, VIM, and NDM carbapenemase genes in 18 out of 88 carbapenem-resistant P. aeruginosa strains.
Genomic epidemiology and temperature dependency of hypermucoviscous Klebsiella pneumoniae in Japan.
The study identifies multiple AMR genes and mutations in hypermucoviscous Klebsiella pneumoniae isolates from Japan, highlighting the presence of ESBLs, carbapenemases, and other resistance determinants. It also reveals temperature-dependent variations in the HMV phenotype and the genetic diversity of the isolates.
Genomic Surveillance of Clinical Pseudomonas aeruginosa Isolates Reveals an Additive Effect of Carbapenemase Production on Carbapenem Resistance.
The study identified several beta-lactamase genes, including bla OXA-50, bla OXA-10, bla OXA-488, bla GES-5, bla IMP-1, bla IMP-10, bla NDM-1, bla VIM-2, bla VIM-6, and bla VIM-11, as well as inactivating mutations in the porin gene oprD, which contribute to carbapenem resistance in Pseudomonas aeruginosa isolates from Pakistan.
Genomic Surveillance of Clinical Pseudomonas aeruginosa Isolates Reveals an Additive Effect of Carbapenemase Production on Carbapenem Resistance.
The study identified several beta-lactamase genes, including bla OXA-50, bla OXA-10, bla OXA-488, bla GES-5, bla IMP-1, bla IMP-10, bla NDM-1, bla VIM-2, bla VIM-6, and bla VIM-11, as well as inactivating mutations in the porin gene oprD, which contribute to carbapenem resistance in Pseudomonas aeruginosa isolates from Pakistan.
Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen.
The study identifies multiple AMR genes and mutations in Klebsiella pneumoniae isolates, including bla CTX-M-15, bla IMP-4, bla OXA-48, qnrB1, qnrS1, aac(6')-Ib-cr, rmtB, aac(6')-Ib4, aadA2, ant(2")-Ia, ermB, arr-2, dfrA14, sul2, and sul1, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, aminoglycosides, and sulfonamides.
Coexistence of tmexCD-toprJ, bla(NDM-1), and bla(IMP-4) in One Plasmid Carried by Clinical Klebsiella spp.
The study identifies the coexistence of tmexCD-toprJ, bla(IMP-4), and bla(NDM-1) in a single plasmid carried by clinical Klebsiella spp., highlighting the potential for horizontal transmission of multiple resistance genes.
BioFire FilmArray Pneumonia Panel enhances detection of pathogens and antimicrobial resistance in lower respiratory tract specimens.
The BioFire FilmArray Pneumonia Panel detected 97 targets, including 84 bacteria and nine antimicrobial resistance markers, enhancing the detection of pathogens and antimicrobial resistance in lower respiratory tract specimens.
Efficacy and In Vitro Activity of Novel Antibiotics for Infections With Carbapenem-Resistant Gram-Negative Pathogens.
The paper characterizes several carbapenemase genes, including KPC, NDM, VIM, and OXA-48-like enzymes, which confer resistance to carbapenems. It also identifies 16S-RMTase as a gene associated with aminoglycoside resistance.
Coexistence of bla (NDM-1) and bla (IMP-4) in One Novel Hybrid Plasmid Confers Transferable Carbapenem Resistance in an ST20-K28 Klebsiella pneumoniae.
The study identifies a novel hybrid plasmid carrying blaNDM-1 and blaIMP-4 in an ST20-K28 carbapenem-resistant Klebsiella pneumoniae strain, which confers transferable carbapenem resistance.
In-vitro susceptibility testing methods for the combination of ceftazidime-avibactam with aztreonam in metallobeta-lactamase producing organisms: Role of combination drugs in antibiotic resistance era.
The study characterizes the resistance mechanisms conferred by blaNDM, blaVIM, and blaIMP genes in metallo-beta-lactamase producing organisms, demonstrating that the combination of ceftazidime-avibactam with aztreonam restores susceptibility.
In Vitro Activity of Ceftolozane-Tazobactam and Other Antibiotics against Pseudomonas aeruginosa Infection-Isolates from an Academic Medical Center in Thailand.
The study identified blaIMP, blaVIM, and blaNDM as the primary resistance mechanisms in ceftolozane-tazobactam-resistant Pseudomonas aeruginosa isolates.
Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches.
The study identifies several AMR genes and mutations associated with resistance to various antibiotics in wastewater environments, highlighting the role of these genes in the spread of antimicrobial resistance.
Epidemiology and clinical characteristics of infection/colonization due to carbapenemase-producing Enterobacterales in neonatal patients.
The study identified blaNDM-1, blaKPC-2, and blaIMP-4 as the primary carbapenemase genes responsible for carbapenem resistance in Enterobacterales isolates from neonatal patients. These genes were predominantly found in Klebsiella pneumoniae and Escherichia coli, contributing to high rates of rectal colonization and infections.
Detection of Klebsiella pneumoniae antibiotic-resistant genes: An impending source of multidrug resistance dissemination through raw food.
The study identified several β-lactamase genes, including bla CTX-M, bla SHV, bla TEM, bla MOX, bla FOX, and carbapenemase genes such as bla NDM, bla IMP, bla VIM, and bla OXA-48, in Klebsiella pneumoniae isolates from raw food samples, highlighting the potential for multidrug resistance dissemination through the food chain.
Analysis of diverse β-lactamases presenting high-level resistance in association with OmpK35 and OmpK36 porins in ESBL-producing Klebsiella pneumoniae.
The study identifies various β-lactamase genes, including bla CTX-M−1, bla CTX-M−15, bla SHV-12, bla SHV-28, bla CYM-2, bla NDM-1, bla NDM-5, bla IMP, and integron-1, which contribute to high-level resistance in ESBL-producing K. pneumoniae. Additionally, the loss of OmpK35 and OmpK36 porins is associated with increased resistance.
Frequent convergence of mcr-9 and carbapenemase genes in Enterobacter cloacae complex driven by epidemic plasmids and host incompatibility.
The study identifies the frequent convergence of mcr-9 and carbapenemase genes in Enterobacter cloacae complex, highlighting the role of epidemic plasmids in their dissemination.
Direct Colorimetry of Imipenem Decomposition as a Novel Cost-Effective Method for Detecting Carbapenemase-Producing Enterobacteria.
The study presents a novel, cost-effective method for detecting carbapenemase-producing enterobacteria (CPE) using direct colorimetry of imipenem decomposition. The method relies on the specific color change induced by carbapenemases, particularly NDM-1, NMC-A, OXA-48, VIM-1, IMP-4, and KPC-2, which were experimentally validated for their ability to hydrolyze imipenem and produce a measurable yellow color. The method demonstrated high sensitivity (98%) and specificity (100%).
Direct Colorimetry of Imipenem Decomposition as a Novel Cost-Effective Method for Detecting Carbapenemase-Producing Enterobacteria.
The study presents a novel, cost-effective method for detecting carbapenemase-producing enterobacteria (CPE) using direct colorimetry of imipenem decomposition. The method relies on the specific color change induced by carbapenemases, particularly NDM-1, NMC-A, OXA-48, VIM-1, IMP-4, and KPC-2, which were experimentally validated for their ability to hydrolyze imipenem and produce a measurable yellow color. The method demonstrated high sensitivity (98%) and specificity (100%).
Direct Colorimetry of Imipenem Decomposition as a Novel Cost-Effective Method for Detecting Carbapenemase-Producing Enterobacteria.
The study presents a novel, cost-effective method for detecting carbapenemase-producing enterobacteria (CPE) using direct colorimetry of imipenem decomposition. The method relies on the specific color change induced by carbapenemases, particularly NDM-1, NMC-A, OXA-48, VIM-1, IMP-4, and KPC-2, which were experimentally validated for their ability to hydrolyze imipenem and produce a measurable yellow color. The method demonstrated high sensitivity (98%) and specificity (100%).
Genomic Characterization of a Multidrug-Resistant Aeromonas caviae Isolate Carrying a Novel bla(KPC-2)-Harbouring Plasmid and an IMP-4-Encoding Phage-like Plasmid.
The study characterizes a multidrug-resistant Aeromonas caviae isolate carrying a novel bla(KPC-2)-harboring plasmid and an IMP-4-encoding phage-like plasmid, highlighting the role of mobile genetic elements in the dissemination of antimicrobial resistance genes.
Emergence and Evolution of Unique Plasmids Harboring bla(IMP-70) and bla(CTX-M-253) in Multidrug-Resistant Providencia rettgeri.
The study identifies bla(IMP-70) and bla(CTX-M-253) as novel beta-lactamase genes in multidrug-resistant Providencia rettgeri, highlighting their role in carbapenem and cephalosporin resistance.
Novel 1,2,3-Triazole-sulphadiazine-ZnO Hybrids as Potent Antimicrobial Agents against Carbapenem Resistant Bacteria.
The study identified the inhibitory effects of 1,2,3-triazole-sulphadiazine-ZnO hybrids against metallo-beta-lactamases (MBLs) IMP-1 and NDM-1, demonstrating their potential as antimicrobial agents against carbapenem-resistant bacteria.
A Selective Medium for Screening Ceftazidime/Avibactam Resistance in Carbapenem-Resistant Enterobacterales.
The study developed an SS CZA medium for screening CZA-resistant CRE isolates, demonstrating 100% sensitivity and specificity. The medium effectively distinguishes between CZA-resistant and -susceptible strains, with resistance determinants including blaNDM, blaKPC, blaCTX-M, blaTEM, blaSHV, blaOXA-23, blaIMP, and ampC.
A novel, magnetic bead-based extraction method for the isolation of antimicrobial resistance genes with a case study in river water in Malawi.
The study presents a novel, magnetic bead-based extraction method called MagnaExtract for isolating antimicrobial resistance genes (ARGs) from river water. The method showed comparable or better performance than commercial kits in terms of DNA yield and detection of ARGs such as bla CTXM-1, bla CTXM-9, bla SHV, bla OXA-48, bla IMP, and bla KPC.
A clinical Pseudomonas juntendi strain with bla (IMP-1) carried by an integrative and conjugative element in China.
The study reports the first clinical isolate of Pseudomonas juntendi in China carrying the blaIMP-1 gene, which confers carbapenem resistance. The gene is part of an integrative and conjugative element (ICE) that facilitates horizontal gene transfer.
Development of Microfluidic Chip-Based Loop-Mediated Isothermal Amplification (LAMP) Method for Detection of Carbapenemase Producing Bacteria.
The study developed a microfluidic chip-based LAMP method for the detection of carbapenemase-producing organisms (CPO) and evaluated its performance in identifying carbapenemase genes such as bla KPC, bla NDM, bla VIM, bla IMP, bla oprD2, bla OXA-23, bla OXA-48, and bla OXA-58.
ESBL plasmids in Klebsiella pneumoniae: diversity, transmission and contribution to infection burden in the hospital setting.
The study identified 25 distinct ESBL plasmids, with Plasmid A carrying bla CTX-M-15 being the most prevalent and contributing significantly to the burden of ceftriaxone-resistant and multidrug-resistant infections in the hospital setting.
Whole-Genome Sequencing Reveals Diversity of Carbapenem-Resistant Pseudomonas aeruginosa Collected through CDC's Emerging Infections Program, United States, 2016-2018.
The Molecular Epidemiology of Prevalent Klebsiella pneumoniae Strains and Humoral Antibody Responses against Carbapenem-Resistant K. pneumoniae Infections among Pediatric Patients in Shanghai.
The study identified the prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) strains among pediatric patients in Shanghai, highlighting the dominance of the blaKPC gene as the primary carbapenemase responsible for resistance. Other carbapenemase genes such as blaNDM, blaIMP, and blaOXA-48 were also detected. Additionally, the study found that CRKP strains exhibited high resistance to beta-lactam antibiotics.
Hitherto-Unnoticed Self-Transmissible Plasmids Widely Distributed among Different Environments in Japan.
The study identified new subgroups of IncP/P-1 and PromA plasmids, including antibiotic resistance genes such as blaIMP-1, blaKPC-2, mcr-1, and various tetracycline and aminoglycoside resistance genes.
Multidrug-Resistant Bacteria: Their Mechanism of Action and Prophylaxis.
The paper reviews the mechanisms of multidrug resistance in bacteria, focusing on resistance mechanisms such as beta-lactamases, vancomycin resistance genes, and other resistance determinants in both Gram-positive and Gram-negative bacteria.
Resistance Phenotype and Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Nanjing Children's Hospital in Jiangsu Province, China.
The study identified several carbapenemase genes, including blaKPC-2, blaNDM-1, blaNDM-5, blaIMP-8, and blaOXA-181, as well as other resistance genes such as blaCTX-M, blaSHV-2, APH(3)-IB, APH(6)-ID, FosA5, tetC, qnrB1, and tetA, contributing to multidrug resistance in CRKP strains isolated from children in Nanjing, China.
Epidemiology, Mechanisms of Resistance and Treatment Algorithm for Infections Due to Carbapenem-Resistant Gram-Negative Bacteria: An Expert Panel Opinion.
The paper discusses the mechanisms of resistance in carbapenem-resistant Gram-negative bacteria, highlighting the role of various beta-lactamases such as blaOXA-51, blaOXA-23, blaOXA-24, blaOXA-48, blaKPC, blaNDM, blaVIM, and blaIMP, as well as aminoglycoside modifying enzymes like aac(6')-Ib and aadA, and quinolone resistance genes such as qnrS1.
Evaluation of the EasyScreen™ ESBL/CPO Detection Kit for the Detection of ß-Lactam Resistance Genes.
The EasyScreen™ ESBL/CPO Detection Kit effectively detects various β-lactam resistance genes, including bla VIM, bla NDM, bla IMP, bla OXA-48, bla KPC, bla OXA-23, bla OXA-51, bla SME, bla IMI, bla GES, bla TEM, bla SHV, bla CTX-M, bla CMY, bla DHA, and the mcr-1 gene, demonstrating high sensitivity and specificity for carbapenemase and ESBL detection in Enterobacterales, Pseudomonas spp., and Acinetobacter spp.
A Plasmid Carrying bla(IMP-56) in Pseudomonas aeruginosa Belonging to a Novel Resistance Plasmid Family.
The study identifies a novel plasmid family carrying the bla(IMP-56) gene, which confers resistance to carbapenems in Pseudomonas aeruginosa.
Structural insights into the substrate specificity of IMP-6 and IMP-1 metallo-β-lactamases.
The study characterizes the structural and functional differences between IMP-1 and IMP-6 metallo-β-lactamases, highlighting how a single amino acid substitution (Ser262 in IMP-1 vs. Gly262 in IMP-6) affects substrate specificity and resistance to carbapenems and beta-lactam antibiotics.
Structural insights into the substrate specificity of IMP-6 and IMP-1 metallo-β-lactamases.
The study characterizes the structural and functional differences between IMP-1 and IMP-6 metallo-β-lactamases, highlighting how a single amino acid substitution (Ser262 in IMP-1 vs. Gly262 in IMP-6) affects substrate specificity and resistance to carbapenems and beta-lactam antibiotics.
Chromosomal coharboring of bla(IMP-60) and mcr-9 in Enterobacter asburiae isolated from a Japanese woman with empyema: a case report.
The study identifies a colistin-resistant Enterobacter asburiae strain harboring mcr-9 and bla(IMP-60) on its chromosome, highlighting the potential for chromosomal mcr-9 to contribute to colistin resistance.
Prevalence of carbapenemase genes among carbapenem-nonsusceptible Enterobacterales collected in US hospitals in a five-year period and activity of ceftazidime/avibactam and comparator agents.
The study identified several carbapenemase genes, including bla KPC, bla OXA-181, bla NDM-1, bla NDM-5, bla VIM-1, and bla IMP-27, in carbapenem-nonsusceptible Enterobacterales isolates. New KPC variants, such as bla KPC-58, were characterized and showed resistance to ceftazidime/avibactam and low meropenem MIC values.
Molecular Characterization of Gene-Mediated Resistance and Susceptibility of ESKAPE Clinical Isolates to Cistus monspeliensis L. and Cistus salviifolius L. Extracts.
The study identified several AMR genes in ESKAPE clinical isolates, including bla CTX-M, bla SHV, bla OXA-48, bla NDM, bla OXA-51, bla OXA-58, bla IMP, bla VIM, bla mecA, and bla VanA, which confer resistance to various antibiotics.
Phenotypic and molecular characterization of IMP-producing Enterobacterales in Spain: Predominance of IMP-8 in Klebsiella pneumoniae and IMP-22 in Enterobacter roggenkampii.
The study identified various IMP carbapenemase types, including IMP-8, IMP-22, IMP-13, IMP-28, and IMP-15, in different Enterobacterales species in Spain. These genes confer resistance to imipenem and meropenem.
Phenotypic and molecular characterization of IMP-producing Enterobacterales in Spain: Predominance of IMP-8 in Klebsiella pneumoniae and IMP-22 in Enterobacter roggenkampii.
The study identified various IMP carbapenemase types, including IMP-8, IMP-22, IMP-13, IMP-28, and IMP-15, in different Enterobacterales species in Spain. These genes confer resistance to imipenem and meropenem.
Phenotypic and molecular characterization of IMP-producing Enterobacterales in Spain: Predominance of IMP-8 in Klebsiella pneumoniae and IMP-22 in Enterobacter roggenkampii.
The study identified various IMP carbapenemase types, including IMP-8, IMP-22, IMP-13, IMP-28, and IMP-15, in different Enterobacterales species in Spain. These genes confer resistance to imipenem and meropenem.
Phenotypic and molecular characterization of IMP-producing Enterobacterales in Spain: Predominance of IMP-8 in Klebsiella pneumoniae and IMP-22 in Enterobacter roggenkampii.
The study identified various IMP carbapenemase types, including IMP-8, IMP-22, IMP-13, IMP-28, and IMP-15, in different Enterobacterales species in Spain. These genes confer resistance to imipenem and meropenem.
Phenotypic and molecular characterization of IMP-producing Enterobacterales in Spain: Predominance of IMP-8 in Klebsiella pneumoniae and IMP-22 in Enterobacter roggenkampii.
The study identified various IMP carbapenemase types, including IMP-8, IMP-22, IMP-13, IMP-28, and IMP-15, in different Enterobacterales species in Spain. These genes confer resistance to imipenem and meropenem.
Molecular Mechanisms Mediating Ceftazidime/Avibactam Resistance Amongst Carbapenem-Resistant Klebsiella pneumoniae Isolates from Cancer Patients.
The study identified bla KPC, bla OXA-48, bla NDM-1, and bla IMP as the primary genes responsible for ceftazidime/avibactam resistance in carbapenem-resistant Klebsiella pneumoniae isolates from cancer patients. Additionally, the absence of ompK35 and ompK36 was associated with resistance.
In Vitro and In Vivo Effect of Amikacin and Imipenem Combinations against Multidrug-Resistant E. coli.
The study identifies bla-IMP and aac(6')-Ib as the primary resistance genes in multidrug-resistant E. coli isolates, demonstrating their role in conferring resistance to carbapenems and aminoglycosides, respectively.
Emergence of an Extensive Drug Resistant Pseudomonas aeruginosa Strain of Chicken Origin Carrying bla(IMP-45), tet(X6), and tmexCD3-toprJ3 on an Inc(pRBL16) Plasmid.
The study identified a multidrug-resistant Pseudomonas aeruginosa strain carrying blaIMP-45, tet(X6), and tmexCD3-toprJ3 on an Inc(pRBL16) plasmid, highlighting the potential of such plasmids as reservoirs for resistance genes.
Phenotypic and genotypic investigation of metallo-β-lactamases in Pseudomonas aeruginosa clinical isolates in Bushehr, Iran.
The study detected blaIMP, blaNDM, and blaVIM genes in Pseudomonas aeruginosa clinical isolates in Bushehr, Iran, highlighting the prevalence of these metallo-β-lactamase genes as a potential public health concern.
Mobile genetic elements in Acinetobacter antibiotic-resistance acquisition and dissemination.
The study highlights the role of mobile genetic elements, particularly insertion sequences (IS), in the acquisition and dissemination of antibiotic resistance in Acinetobacter species. IS elements can enhance the expression of intrinsic beta-lactamase genes, such as bla OXA-23, bla OXA-51, and ampC, leading to carbapenem and cephalosporin resistance. Additionally, IS elements can disrupt genes involved in antibiotic uptake, such as porins, and alter the expression of efflux pumps, contributing to multidrug resistance.
Evaluation of phenotypic detection of carbapenemase-producing Pseudomonas spp. from clinical isolates.
The study evaluated the performance of phenotypic tests (Carba NP, Blue Carba, and mCIM/eCIM) for detecting carbapenemase-producing Pseudomonas spp. in Brazil. It identified several carbapenemase genes, including bla VIM-2, bla SPM-1, bla IMP-10, bla VIM-24, bla NDM-1, and bla KPC-2, in clinical isolates.
Whole-Genome Sequencing-Based Species Classification, Multilocus Sequence Typing, and Antimicrobial Resistance Mechanism Analysis of the Enterobacter cloacae Complex in Southern China.
The study identified 80 antibiotic resistance genes in 172 Enterobacter cloacae complex isolates, with a focus on beta-lactamases, aminoglycosides, and fluoroquinolones. Key genes included blaACT-2, blaACT-3, blaACT-6, blaACT-9, blaACT-12, blaTEM-1D, blaCTX-M-3, blaSHV-12, blaNDM-1, blaNDM-5, blaIMP-1, blaIMP-4, blaIMP-26, blaKPC-2, qnrS2, qnrE1, aac(6')-Ib, aac(6')-IIc, aph(3')-Ib, aph(6)-Id, aadA, sul2, dfrA12, tetA, ereA, floR, catA2, mcr-10, arr-6, and fosA3.
Whole-Genome Sequencing-Based Species Classification, Multilocus Sequence Typing, and Antimicrobial Resistance Mechanism Analysis of the Enterobacter cloacae Complex in Southern China.
The study identified 80 antibiotic resistance genes in 172 Enterobacter cloacae complex isolates, with a focus on beta-lactamases, aminoglycosides, and fluoroquinolones. Key genes included blaACT-2, blaACT-3, blaACT-6, blaACT-9, blaACT-12, blaTEM-1D, blaCTX-M-3, blaSHV-12, blaNDM-1, blaNDM-5, blaIMP-1, blaIMP-4, blaIMP-26, blaKPC-2, qnrS2, qnrE1, aac(6')-Ib, aac(6')-IIc, aph(3')-Ib, aph(6)-Id, aadA, sul2, dfrA12, tetA, ereA, floR, catA2, mcr-10, arr-6, and fosA3.
Whole-Genome Sequencing-Based Species Classification, Multilocus Sequence Typing, and Antimicrobial Resistance Mechanism Analysis of the Enterobacter cloacae Complex in Southern China.
The study identified 80 antibiotic resistance genes in 172 Enterobacter cloacae complex isolates, with a focus on beta-lactamases, aminoglycosides, and fluoroquinolones. Key genes included blaACT-2, blaACT-3, blaACT-6, blaACT-9, blaACT-12, blaTEM-1D, blaCTX-M-3, blaSHV-12, blaNDM-1, blaNDM-5, blaIMP-1, blaIMP-4, blaIMP-26, blaKPC-2, qnrS2, qnrE1, aac(6')-Ib, aac(6')-IIc, aph(3')-Ib, aph(6)-Id, aadA, sul2, dfrA12, tetA, ereA, floR, catA2, mcr-10, arr-6, and fosA3.
Epidemiological characteristics and molecular features of carbapenem-resistant Enterobacter strains in China: a multicenter genomic study.
The study identified bla NDM-1, bla NDM-5, bla IMP-26, bla IMP-4, and bla VIM-1 as the primary carbapenemase-encoding genes in carbapenem-resistant Enterobacter strains in China, with bla NDM being the most prevalent.
Epidemiological characteristics and molecular features of carbapenem-resistant Enterobacter strains in China: a multicenter genomic study.
The study identified bla NDM-1, bla NDM-5, bla IMP-26, bla IMP-4, and bla VIM-1 as the primary carbapenemase-encoding genes in carbapenem-resistant Enterobacter strains in China, with bla NDM being the most prevalent.
Detection of IMP-4 and SFO-1 co-producing ST51 Enterobacter hormaechei clinical isolates.
The study identified the co-production of IMP-4 and SFO-1 in ST51 Enterobacter hormaechei clinical isolates, highlighting the presence of a transferable IncN-type plasmid carrying blaIMP-4 and the genetic context of blaIMP-4 and blaSFO-1.
Beta-lactamase determinants and molecular typing of carbapenem-resistant classic and hypervirulent Klebsiella pneumoniae clinical isolates from southwest of Iran.
The study identified several beta-lactamase genes, including bla NDM, bla IMP, bla VIM, bla GES, bla OXA-48-like, bla CTX-M, bla SHV, bla TEM, bla FOX, bla DHA, bla CMY, bla LAT, and bla ACT, which are responsible for carbapenem resistance in Klebsiella pneumoniae isolates from southwest Iran.
Occurrence of virulence factors and carbapenemase genes in Salmonella enterica serovar Enteritidis isolated from chicken meat and egg samples in Iraq.
The study identified carbapenemase genes blaIMP, blaOXA-48-like, and blaNDM, along with tetracycline resistance genes tetA and tetB, and trimethoprim-sulfamethoxazole resistance genes dfrA1 and sul1 in Salmonella enterica serovar Enteritidis isolates from chicken meat and eggs in Iraq.
Carbapenem resistance gene crisis in A. baumannii: a computational analysis.
The study identified several carbapenem resistance genes including blaOXA-51, blaOXA-23, blaOXA-58, blaOXA-24, blaOXA-143, NMD-1, IMP-1, and recA in Acinetobacter baumannii through computational analysis and molecular docking experiments.
Phenotypic and genotypic characterization of metallo-beta-lactamase producing Pseudomonas aeruginosa isolated from burn patients.
The study identified blaVIM and blaIMP genes in imipenem-resistant Pseudomonas aeruginosa isolates from burn patients, highlighting the prevalence of metallo-beta-lactamase production.
Increased zinc levels facilitate phenotypic detection of ceftazidime-avibactam resistance in metallo-β-lactamase-producing Gram-negative bacteria.
The study identifies several metallo-beta-lactamase genes (blaIMP-1, blaNDM-1, blaNDM-5, blaVIM-1, blaVIM-2, and blaVIM-4) that confer resistance to ceftazidime-avibactam in various Gram-negative bacteria. It highlights the importance of zinc supplementation in improving the detection of ceftazidime-avibactam resistance in metallo-beta-lactamase-producing isolates.
Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae in a Tertiary Hospital in Northern China.
The study identified bla KPC-2, bla GES, bla NDM-1, and bla IMP as the main carbapenemase genes in CRKP isolates. Additionally, various ESBL genes, aminoglycoside resistance genes, and PMQR genes were detected.
Characterization of Acinetobacter baumannii Isolated from Raw Milk.
The study identified blaOXA-51, blaOXA-23, blaIMP, and blaNDM genes in Acinetobacter baumannii isolates from raw milk, indicating carbapenem resistance.
Efficacy of Vaporized Hydrogen Peroxide Combined with Silver Ions against Multidrug-Resistant Gram-Negative and Gram-Positive Clinical Isolates.
The study evaluated the efficacy of 8% vaporized hydrogen peroxide combined with 30 mg/L silver ions against multidrug-resistant (MDR) clinical isolates of Klebsiella pneumoniae, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus. It identified specific carbapenemase genes (bla KPC, bla VIM, bla IMP, bla NDM, and bla OXA-48) associated with resistance in these isolates.
Genotypic characterization and clonal relatedness of metallo-beta-lactamase-producing non-fermentative gram negative bacteria in the first 5 years of their circulation in Paraguay (2011-2015).
The study identified blaVIM-2, blaNDM-1, and blaIMP-18 as the主要 metallo-beta-lactamase genes in non-fermentative gram-negative bacteria in Paraguay, highlighting their prevalence and clonal spread.
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review.
The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review.
The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review.
The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review.
The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review.
The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review.
The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review.
The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review.
The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review.
The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review.
The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review.
The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.
Carbapenem-resistant hypermucoviscous Klebsiella pneumoniae clinical isolates from a tertiary hospital in China: Antimicrobial susceptibility, resistance phenotype, epidemiological characteristics, microbial virulence, and risk factors.
The study identified bla KPC-2, bla NDM, bla IMP, and bla OXA-48-like as the main carbapenemase genes in carbapenem-resistant K. pneumoniae (CRKP) isolates. These genes conferred resistance to carbapenems, cephalosporins, and fluoroquinolones. The study also highlighted the importance of CZA in treating CRKP infections.
Characterization of a Conjugative Hybrid Plasmid Coharboring bla(KPC-2) and bla(IMP-4) in a Klebsiella quasipneumoniae Clinical Isolate.
The study characterizes a conjugative hybrid plasmid co-harboring bla(KPC-2) and bla(IMP-4) in a clinical isolate of Klebsiella quasipneumoniae, highlighting the evolution and transmission of resistance genes through recombination events.
Expanded catalogue of metagenome-assembled genomes reveals resistome characteristics and athletic performance-associated microbes in horse.
The study identified a diverse array of antibiotic resistance genes (ARG) in the horse gut microbiome, highlighting the widespread use of antibiotics in horse management. The resistome characteristics were analyzed alongside the identification of microbes associated with athletic performance.
An XDR Pseudomonas aeruginosa ST463 Strain with an IncP-2 Plasmid Containing a Novel Transposon Tn6485f Encoding bla(IMP-45) and bla(AFM-1) and a Second Plasmid with Two Copies of bla(KPC-2).
The study identifies a novel transposon Tn6485f containing blaIMP-45 and blaAFM-1, along with a second plasmid with two copies of blaKPC-2, contributing to the XDR phenotype of the P. aeruginosa ST463 strain PA30.
Susceptibility profile of bla (OXA-23) and metallo-β-lactamases co-harbouring isolates of carbapenem resistant Acinetobacter baumannii (CRAB) against standard drugs and combinations.
The study identified bla OXA-51, bla OXA-23, bla IMP, bla NDM, and bla VIM as the primary carbapenemase genes in CRAB isolates, with bla OXA-23 and bla NDM being particularly prevalent. These genes conferred resistance to carbapenems, and the presence of bla NDM was linked to reduced synergy in combination therapies.
Development of a novel loop-mediated isothermal amplification assay for ß-lactamase gene identification using clinical isolates of Gram-negative bacteria.
The study developed LAMP assays for four β-lactamase genes (bla KPC, bla NDM-1, bla IMP-1 group, and bla VIM) and validated their specificity and sensitivity using clinical isolates of Gram-negative bacteria.
Evaluation of Xpert Carba-R for detecting carbapenemase-producing organisms in South Africa.
The Xpert Carba-R assay demonstrated high performance in detecting carbapenemase-producing organisms, with 98% sensitivity and 97% specificity. It successfully identified various carbapenemase genes, including bla KPC, bla NDM, bla VIM, bla OXA-48, and bla IMP-1, in both cultured isolates and spiked rectal swabs.
Prevalence and Characterization of Beta-Lactam and Carbapenem-Resistant Bacteria Isolated from Organic Fresh Produce Retailed in Eastern Spain.
The study identified various beta-lactamase genes, including bla_VIM, bla_IMP, bla_TEM, bla_OXA-48, bla_SHV, bla_CMY-2, and bla_KPC, in beta-lactam and carbapenem-resistant bacteria isolated from organic fresh produce in Valencia, Spain.
Ertapenem Supplemented Selective Media as a New Strategy to Distinguish β-Lactam-Resistant Enterobacterales: Application to Clinical and Wastewater Samples.
The study identifies blaIMP-4 and blaKPC as the primary carbapenemase genes responsible for carbapenem resistance in Enterobacterales, demonstrating their presence in clinical and environmental samples through experimental validation.
Molecular Mechanisms of Resistance to Ceftazidime/Avibactam in Clinical Isolates of Enterobacterales and Pseudomonas aeruginosa in Latin American Hospitals.
The study identifies multiple AMR genes and mutations contributing to CZA resistance in Enterobacterales and P. aeruginosa, including MBLs, blaKPC, blaVIM, blaIMP, blaNDM, blaSPM-1, and various mutations in genes related to efflux pumps, porins, and beta-lactamases.
Genomic and clinical characteristics of carbapenem-resistant Enterobacter cloacae complex isolates collected in a Chinese tertiary hospital during 2013-2021.
The study identified blaNDM-1 and blaIMP-4 as the main carbapenem resistance genes in Enterobacter cloacae complex isolates, along with blaSHV-12 and blaTEM-1B as major extended-spectrum beta-lactamases. Additionally, mcr-9 was highly prevalent as a mobile colistin resistance gene.
Association between Intestinal Colonization and Extraintestinal Infection with Carbapenem-Resistant Klebsiella pneumoniae in Children.
The study identifies carbapenem-resistant Klebsiella pneumoniae (CRKP) strains with specific resistance genes such as blaKPC-2, blaNDM-1, and blaIMP-4, along with virulence factors like mrk, kfu, iuc, and iro. It also characterizes a novel subclone CR-hvKP KL19-ST15 associated with hypervirulence and poor patient outcomes.
Characterization of Third Generation Cephalosporin- and Carbapenem-Resistant Aeromonas Isolates from Municipal and Hospital Wastewater.
The study identified several carbapenemase and ESBL genes in Aeromonas isolates from wastewater, highlighting the presence of bla KPC-2, bla VIM-2, bla OXA-48, bla IMP-13, bla GES-5, and bla MOX as significant contributors to antibiotic resistance.
Epidemiological and Genetic Characteristics of Clinical Carbapenem-Resistant Pseudomonas aeruginosa Strains in Guangdong Province, China.
The study identified blaIMP-45 as a major determinant of meropenem resistance in P. aeruginosa, and mutations in oprD, mexR, nalD, and armR were associated with meropenem resistance.
Genotyping and molecular investigation of plasmid-mediated carbapenem resistant clinical Klebsiella pneumoniae isolates in Egypt.
The study identified the prevalence of carbapenem resistance genes (blaIMP, blaVIM, blaOXA-48, blaNDM, and blaKPC) in clinical Klebsiella pneumoniae isolates in Egypt, highlighting the high levels of resistance and the potential for horizontal gene transfer.
Characterization of Three Novel IMP Metallo-β-Lactamases, IMP-89, IMP-91, and IMP-96, and Diverse bla(IMP)-Carrying Accessory Genetic Elements from Chinese Clinical Isolates.
Three novel IMP metallo-beta-lactamases, IMP-89, IMP-91, and IMP-96, were characterized. These enzymes confer resistance to cephalosporins and carbapenems. IMP-96 exhibits increased resistance to meropenem due to the Ser262Gly mutation.
Characterization of Three Novel IMP Metallo-β-Lactamases, IMP-89, IMP-91, and IMP-96, and Diverse bla(IMP)-Carrying Accessory Genetic Elements from Chinese Clinical Isolates.
Three novel IMP metallo-beta-lactamases, IMP-89, IMP-91, and IMP-96, were characterized. These enzymes confer resistance to cephalosporins and carbapenems. IMP-96 exhibits increased resistance to meropenem due to the Ser262Gly mutation.
Characterization of Three Novel IMP Metallo-β-Lactamases, IMP-89, IMP-91, and IMP-96, and Diverse bla(IMP)-Carrying Accessory Genetic Elements from Chinese Clinical Isolates.
Three novel IMP metallo-beta-lactamases, IMP-89, IMP-91, and IMP-96, were characterized. These enzymes confer resistance to cephalosporins and carbapenems. IMP-96 exhibits increased resistance to meropenem due to the Ser262Gly mutation.
Antibiotic Resistance Profiles and ARG Detection from Isolated Bacteria in a Culture-Dependent Study at the Codfish Industry Level.
The study identified various antibiotic resistance genes in bacteria isolated from codfish products and environmental samples, highlighting the presence of tetracycline, clindamycin, and oxacillin resistance genes in Staphylococcus spp., as well as beta-lactam and carbapenem resistance genes in Gram-negative bacteria.
Snapshot of Phenotypic and Molecular Virulence and Resistance Profiles in Multidrug-Resistant Strains Isolated in a Tertiary Hospital in Romania.
The study identified multiple beta-lactamase genes (bla CTX-M, bla SHV, bla TEM, bla KPC, bla OXA-48, bla NDM, bla OXA-23, bla OXA-24, bla VIM, and bla IMP) in multidrug-resistant strains of Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa. Additionally, several virulence genes involved in biofilm formation and tissue destruction were detected.
The emergence of plasmid-encoded oxacillinase and carbapenemase among uropathogenic Escherichia coli (UPEC) isolated from hospitalized patients in the North of Iran.
The study identified OXA-1 and IMP genes as the primary carbapenem resistance determinants in UPEC isolates from hospitalized patients in northern Iran, with OXA-1 showing a significant association with imipenem resistance.
Whole-genome sequencing reveals high-risk clones of Pseudomonas aeruginosa in Guangdong, China.
The study identified multiple AMR genes, including aac(6')-IIa, aac(6')-Ib4, aac(6')-Ib7, aac(6')-Ib9, aac(6')-Ib10, aac(3)-IId, aadA, aadA2, aadA3, aadA7, aadA13, bla OXA-50-Like, bla OXA-1-Like, bla OXA-10-Like, bla OXA-21-Like, bla VIM-2, bla IMP-9, bla IMP-45, bla KPC-2, bla CTX-M-13, bla CARB-1, bla CARB-3, qnrVC1, qnrVC6, bla PDC-3, and bla PDC-5, in Pseudomonas aeruginosa isolates from Guangdong, China, highlighting the high prevalence of multidrug-resistant and carbapenem-resistant strains.
Whole-genome sequencing reveals high-risk clones of Pseudomonas aeruginosa in Guangdong, China.
The study identified multiple AMR genes, including aac(6')-IIa, aac(6')-Ib4, aac(6')-Ib7, aac(6')-Ib9, aac(6')-Ib10, aac(3)-IId, aadA, aadA2, aadA3, aadA7, aadA13, bla OXA-50-Like, bla OXA-1-Like, bla OXA-10-Like, bla OXA-21-Like, bla VIM-2, bla IMP-9, bla IMP-45, bla KPC-2, bla CTX-M-13, bla CARB-1, bla CARB-3, qnrVC1, qnrVC6, bla PDC-3, and bla PDC-5, in Pseudomonas aeruginosa isolates from Guangdong, China, highlighting the high prevalence of multidrug-resistant and carbapenem-resistant strains.
High-resolution characterization of short-term temporal variability in the taxonomic and resistome composition of wastewater influent.
The study highlights the importance of 24 h composite sampling over single grab sampling for capturing the full diversity of AMR gene families in wastewater influent, particularly for carbapenemase genes like bla VIM, bla KPC, bla IMP, and bla NDM, which were intermittently missed by grab sampling but reliably detected in composites.
International Epidemiology of Carbapenemase-Producing Escherichia coli.
The study identifies various carbapenemase genes, including bla NDM-5, bla KPC-2, and others, in carbapenemase-producing Escherichia coli isolates from different geographical regions.
Molecular characteristics of clinical IMP-producing Klebsiella pneumoniae isolates: novel IMP-90 and integron In2147.
The study identifies a novel IMP-type metallo-beta-lactamase, IMP-90, and a novel integron In2147 carrying blaIMP-90. It also reports the presence of known blaIMP variants (blaIMP-1, blaIMP-4, and blaIMP-26) in various plasmid types.
Molecular characteristics of clinical IMP-producing Klebsiella pneumoniae isolates: novel IMP-90 and integron In2147.
The study identifies a novel IMP-type metallo-beta-lactamase, IMP-90, and a novel integron In2147 carrying blaIMP-90. It also reports the presence of known blaIMP variants (blaIMP-1, blaIMP-4, and blaIMP-26) in various plasmid types.
Molecular characteristics of clinical IMP-producing Klebsiella pneumoniae isolates: novel IMP-90 and integron In2147.
The study identifies a novel IMP-type metallo-beta-lactamase, IMP-90, and a novel integron In2147 carrying blaIMP-90. It also reports the presence of known blaIMP variants (blaIMP-1, blaIMP-4, and blaIMP-26) in various plasmid types.
Molecular characteristics of clinical IMP-producing Klebsiella pneumoniae isolates: novel IMP-90 and integron In2147.
The study identifies a novel IMP-type metallo-beta-lactamase, IMP-90, and a novel integron In2147 carrying blaIMP-90. It also reports the presence of known blaIMP variants (blaIMP-1, blaIMP-4, and blaIMP-26) in various plasmid types.
Evaluation of the NG-Test CARBA 5 Lateral Flow Assay with an IMP-27-Producing Morganella morganii and Other Morganellaceae.
The study identifies the blaIMP-27 gene in an IMP-27-producing Morganella morganii isolate, highlighting issues with false-positive NDM results in the NG-Test CARBA 5 assay when using excessive inoculum.
Development and evaluation of a centrifugal disk system for the rapid detection of multiple pathogens and their antibiotic resistance genes in urinary tract infection.
The study developed a centrifugal disk system (LCD) for the rapid detection of multiple pathogens and their antibiotic resistance genes (ARGs) in urinary tract infections (UTIs). The LCD platform demonstrated high specificity and sensitivity for detecting pathogens and ARGs, including beta-lactamases (SHV, TEM, CTX-M-1 group, CTX-M-9 group), carbapenemases (KPC, NDM, IMP, OXA-23, OXA-24, OXA-48), ampC beta-lactamases (DHA, CMY), glycopeptide resistance (VanA), and methicillin resistance (mecA).
Genomic surveillance of multidrug-resistant Klebsiella in Wales reveals persistent spread of Klebsiella pneumoniae ST307 and adaptive evolution of pOXA-48-like plasmids.
The study identifies various carbapenemase genes, including bla_OXA-244, bla_KPC-2, bla_OXA-48, bla_VIM-4, bla_IMP-4, and bla_CTX-M-15, which contribute to multidrug resistance in Klebsiella isolates in Wales.
Multicenter Evaluation of the BIOFIRE Blood Culture Identification 2 Panel for Detection of Bacteria, Yeasts, and Antimicrobial Resistance Genes in Positive Blood Culture Samples.
The BIOFIRE BCID2 Panel demonstrated high sensitivity and specificity for detecting bacteria, yeasts, and antimicrobial resistance genes in positive blood culture samples. It effectively identified various AMR genes such as CTX-M, IMP, KPC, NDM, OXA-48-like, VIM, mecA/C, mcr-1, and vanA/B in Enterobacterales and other pathogens.
Characterization of multidrug and heavy metal resistance of carbapenemases producing Klebsiella pneumoniae from poultry samples in Bangladesh.
The study identified multiple AMR genes, including bla TEM, bla SIM-1, bla IMP-4, bla OXA-48, and qnr B, in carbapenemase-producing Klebsiella pneumoniae isolates from poultry in Bangladesh, highlighting the prevalence of multidrug resistance.
Surveillance of carbapenem-resistant organisms using next-generation sequencing.
The study highlights the importance of next-generation sequencing (NGS) in detecting carbapenem-resistant organisms (CRO) and characterizing resistance genes such as blaKPC, blaNDM, blaVIM, blaIMP, and blaOXA-48. These genes were identified through PCR testing and sequencing, demonstrating their role in carbapenem resistance in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii.
Carbapenem triggers dissemination of chromosomally integrated carbapenemase genes via conjugative plasmids in Escherichia coli.
The study shows that chromosomally integrated blaIMP-6 can be released as a plasmid upon meropenem exposure, leading to enhanced carbapenem resistance in E. coli.
Source-tracking ESBL-producing bacteria at the maternity ward of Mulago hospital, Uganda.
The study identified bla CTX-M, bla TEM, bla SHV, bla VIM, bla IMP, and bla NDM genes as the primary drivers of extended-spectrum beta-lactamase (ESBL) and carbapenemase resistance in E. coli, K. pneumoniae, and Enterobacter spp. isolates from the maternity ward of Mulago Hospital, Uganda.
The carbapenem inoculum effect provides insight into the molecular mechanisms underlying carbapenem resistance in Enterobacterales.
The study identified that various carbapenemase genes, including blaKPC-3, blaSME-2, blaIMP-4, blaNDM-1, blaVIM-27, blaCMY-10, and blaOXA-48, confer a meropenem inoculum effect when expressed in E. coli K-12. These genes were experimentally validated to show increased resistance with higher inocula.
Cefiderocol Treatment for Patients with Multidrug- and Carbapenem-Resistant Pseudomonas aeruginosa Infections in the Compassionate Use Program.
The study identified various beta-lactamase genes, including bla GES, bla VEB-9, bla PER-1, bla NDM-1, bla VIM-2, bla IMP-15, and bla IMP-18, as well as PDC variants like bla PDC-3 and bla PDC-19A, which contribute to resistance against ceftolozane-tazobactam and ceftazidime-avibactam in multidrug-resistant and carbapenem-resistant Pseudomonas aeruginosa isolates.
Cefiderocol Treatment for Patients with Multidrug- and Carbapenem-Resistant Pseudomonas aeruginosa Infections in the Compassionate Use Program.
The study identified various beta-lactamase genes, including bla GES, bla VEB-9, bla PER-1, bla NDM-1, bla VIM-2, bla IMP-15, and bla IMP-18, as well as PDC variants like bla PDC-3 and bla PDC-19A, which contribute to resistance against ceftolozane-tazobactam and ceftazidime-avibactam in multidrug-resistant and carbapenem-resistant Pseudomonas aeruginosa isolates.
Coexistence of bla(IMP-4), bla(NDM-1) and bla(OXA-1) in bla(KPC-2)-producing Citrobacter freundii of clinical origin in China.
The study identifies the coexistence of bla(IMP-4), bla(NDM-1), bla(OXA-1), and bla(KPC-2) in a multidrug-resistant Citrobacter freundii isolate, highlighting the complex mechanisms of carbapenem resistance.
Long-read sequencing reveals genomic diversity and associated plasmid movement of carbapenemase-producing bacteria in a UK hospital over 6 years.
The study identified bla NDM-1 and bla OXA-48 as the most prevalent carbapenemase genes in carbapenemase-producing bacteria in a UK hospital over six years, highlighting the importance of plasmid-mediated transmission in the spread of resistance.
Genome-Based Epidemiologic Analysis of VIM/IMP Carbapenemase-Producing Enterobacter spp., Poland.
The study identified multiple bla VIM and bla IMP genes, along with various other AMR genes, in VIM/IMP carbapenemase-producing Enterobacter spp. in Poland. These genes were associated with different integrons and plasmid types, contributing to the spread of multidrug-resistant strains.
Cluster of Carbapenemase-Producing Carbapenem-Resistant Pseudomonas aeruginosa Among Patients in an Adult Intensive Care Unit - Idaho, 2021-2022.
The study identified the blaIMP-84 gene, a carbapenemase-producing gene, in carbapenem-resistant Pseudomonas aeruginosa isolates from two patients and an ICU room sink, highlighting the role of environmental reservoirs in the transmission of multidrug-resistant organisms.
Extended-spectrum beta-lactamase-producing E. coli from retail meat and workers: genetic diversity, virulotyping, pathotyping and the antimicrobial effect of silver nanoparticles.
The study identified multiple AMR genes in ESBL-producing E. coli from retail meat and workers, including bla IMP, bla TEM, bla CTX-M-1, bla VIM, bla NDM, tetA (A), tetA (B), sul, flo R, and mcr-1. These genes conferred resistance to various antibiotics such as β-lactams, tetracycline, sulfonamides, fluoroquinolones, and colistin.
Abundance and prevalence of ESBL coding genes in patients undergoing first line eradication therapy for Helicobacter pylori.
The study identified several ESBL coding genes, including bla OXY, bla ADC, bla IMP, bla OXA, bla L1, bla LRA, bla EC, bla ACI, and bla FAR, which were found to be prevalent in patients undergoing H. pylori eradication therapy. The abundance of these genes varied between pre- and post-eradication states.
Screening for Resistant Bacteria, Antimicrobial Resistance Genes, Sexually Transmitted Infections and Schistosoma spp. in Tissue Samples from Predominantly Vaginally Delivered Placentae in Ivory Coast and Ghana.
The study identified multiple beta-lactamase genes, including bla CTX-M, bla IMP, bla GES, bla VIM, bla OXA-58-like, bla NDM, bla OXA-23-like, bla OXA-48-like, and bla KPC, in placental tissue samples from Ivory Coast and Ghana. These genes confer resistance to various beta-lactam antibiotics, indicating a high prevalence of antimicrobial resistance in the studied region.
Clinically Isolated β-Lactam-Resistant Gram-Negative Bacilli in a Philippine Tertiary Care Hospital Harbor Multi-Class beta-lactamase Genes.
The study identified multiple beta-lactamase genes in β-lactam-resistant Gram-negative bacilli from a Philippine hospital, highlighting the co-harbor of multi-class beta-lactamases and the presence of cryptic metallo-beta-lactamases in carbapenem-susceptible isolates.
Phenotypic and Genotypic Analysis of Bacterial Pathogens Recovered from Patients Diagnosed with Fever of Unknown Origin in Egypt.
The study identified bla OXA−48, bla VIM, bla IMP, bla TEM, bla CTX-M, aac(6′)-Ib, and bla SHV as prevalent resistance genes in multidrug-resistant (MDR) bacterial isolates from patients with fever of unknown origin in Egypt.
Impact of acquired broad-spectrum beta-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam beta-lactamase inhibitors in Escherichia coli.
The study evaluates the impact of various beta-lactamases on the susceptibility of Escherichia coli to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and their combinations with beta-lactamase inhibitors avibactam and taniborbactam.
Evaluation of NG-Test CARBA 5 version 2, Cepheid Xpert Carba-R, and carbapenem inactivation methods in comparison to whole-genome sequencing for the identification of carbapenemases in non-fermenting Gram-negative bacilli.
The study evaluated the performance of NG-Test CARBA 5, Xpert Carba-R, and carbapenem inactivation methods for identifying carbapenemases in non-fermenting Gram-negative bacilli. It found that NG-Test CARBA 5 showed good performance for carbapenemase detection in Pseudomonas aeruginosa but had issues with false positives for IMP in Acinetobacter baumannii.
Evaluation of NG-Test CARBA 5 version 2, Cepheid Xpert Carba-R, and carbapenem inactivation methods in comparison to whole-genome sequencing for the identification of carbapenemases in non-fermenting Gram-negative bacilli.
The study evaluated the performance of NG-Test CARBA 5, Xpert Carba-R, and carbapenem inactivation methods for identifying carbapenemases in non-fermenting Gram-negative bacilli. It found that NG-Test CARBA 5 showed good performance for carbapenemase detection in Pseudomonas aeruginosa but had issues with false positives for IMP in Acinetobacter baumannii.
Evaluation of NG-Test CARBA 5 version 2, Cepheid Xpert Carba-R, and carbapenem inactivation methods in comparison to whole-genome sequencing for the identification of carbapenemases in non-fermenting Gram-negative bacilli.
The study evaluated the performance of NG-Test CARBA 5, Xpert Carba-R, and carbapenem inactivation methods for identifying carbapenemases in non-fermenting Gram-negative bacilli. It found that NG-Test CARBA 5 showed good performance for carbapenemase detection in Pseudomonas aeruginosa but had issues with false positives for IMP in Acinetobacter baumannii.
Co-existence of bla(IMP), bla(NDM-1), and bla(SHV), genes of Pseudomonas aeruginosa isolated from Quetta: Antimicrobial resistance and clinical significance.
The study identified the co-existence of bla(IMP), bla(NDM-1), and bla(SHV) genes in Pseudomonas aeruginosa isolates from Quetta, indicating extensive drug resistance.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Analyses of Extended-Spectrum-β-Lactamase, Metallo-β-Lactamase, and AmpC-β-Lactamase Producing Enterobacteriaceae from the Dairy Value Chain in India.
The study identified several β-lactamase genes, including bla CMY, bla MOX, bla FOX, bla EBC, bla DHA, bla CTX-M1, bla SHV, bla TEM, bla VIM, bla IMP, bla SPM, bla SIM, and bla GIM, in Enterobacteriaceae isolates from milk samples in India, highlighting the presence of multidrug-resistant bacteria in the dairy value chain.
Comparative Genomics Reveals Novel Species and Insights into the Biotechnological Potential, Virulence, and Resistance of Alcaligenes.
The study identifies multiple antimicrobial resistance genes in Alcaligenes species, particularly in clinical isolates, highlighting the presence of genes conferring resistance to β-lactams, aminoglycosides, sulfonamides, and other antibiotics.
Genomic Characterization of IMP-Producing Pseudomonas aeruginosa in Bulgaria Reveals the Emergence of IMP-100, a Novel Plasmid-Mediated Variant Coexisting with a Chromosomal VIM-4.
The study reports the first occurrence of IMP-producing P. aeruginosa in Bulgaria, identifying a novel plasmid-mediated IMP-100 allele and a chromosomal VIM-4 gene. The p4782-IMP plasmid conferred resistance to multiple antibiotics, including cefiderocol.
Hospital-acquired infections due to carbapenem-resistant Providencia stuartii.
The study identified carbapenem-resistant Providencia stuartii (CRPS) isolates harboring bla NDM-1 and bla IMP genes, leading to resistance against carbapenems.
In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales.
Xeruborbactam (XER) showed superior in vitro potency against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales when combined with various β-lactam antibiotics compared to other β-lactam/β-lactamase inhibitor combinations. XER effectively inhibited a wide range of β-lactamases, including metallo-β-lactamases (MBLs) and serine β-lactamases, enhancing the activity of antibiotics such as meropenem, cefepime, ceftolozane, ceftriaxone, aztreonam, piperacillin, and ertapenem.
In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales.
Xeruborbactam (XER) showed superior in vitro potency against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales when combined with various β-lactam antibiotics compared to other β-lactam/β-lactamase inhibitor combinations. XER effectively inhibited a wide range of β-lactamases, including metallo-β-lactamases (MBLs) and serine β-lactamases, enhancing the activity of antibiotics such as meropenem, cefepime, ceftolozane, ceftriaxone, aztreonam, piperacillin, and ertapenem.
In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales.
Xeruborbactam (XER) showed superior in vitro potency against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales when combined with various β-lactam antibiotics compared to other β-lactam/β-lactamase inhibitor combinations. XER effectively inhibited a wide range of β-lactamases, including metallo-β-lactamases (MBLs) and serine β-lactamases, enhancing the activity of antibiotics such as meropenem, cefepime, ceftolozane, ceftriaxone, aztreonam, piperacillin, and ertapenem.
In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales.
Xeruborbactam (XER) showed superior in vitro potency against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales when combined with various β-lactam antibiotics compared to other β-lactam/β-lactamase inhibitor combinations. XER effectively inhibited a wide range of β-lactamases, including metallo-β-lactamases (MBLs) and serine β-lactamases, enhancing the activity of antibiotics such as meropenem, cefepime, ceftolozane, ceftriaxone, aztreonam, piperacillin, and ertapenem.
In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales.
Xeruborbactam (XER) showed superior in vitro potency against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales when combined with various β-lactam antibiotics compared to other β-lactam/β-lactamase inhibitor combinations. XER effectively inhibited a wide range of β-lactamases, including metallo-β-lactamases (MBLs) and serine β-lactamases, enhancing the activity of antibiotics such as meropenem, cefepime, ceftolozane, ceftriaxone, aztreonam, piperacillin, and ertapenem.
In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales.
Xeruborbactam (XER) showed superior in vitro potency against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales when combined with various β-lactam antibiotics compared to other β-lactam/β-lactamase inhibitor combinations. XER effectively inhibited a wide range of β-lactamases, including metallo-β-lactamases (MBLs) and serine β-lactamases, enhancing the activity of antibiotics such as meropenem, cefepime, ceftolozane, ceftriaxone, aztreonam, piperacillin, and ertapenem.
Clinical and molecular epidemiology of carbapenem-resistant Enterobacteriaceae in pediatric inpatients in South China.
The study identified blaNDM-5, blaNDM-1, blaIMP-4, and blaKPC-2 as the most prevalent carbapenemase genes in CRE isolates from pediatric inpatients in South China.
Genomic epidemiology and heterogeneity of Providencia and their bla(NDM-1)-carrying plasmids.
The study identified blaNDM-1 and blaIMP genes as the main carbapenemase genes in Providencia, highlighting their role in multidrug resistance and the importance of plasmid-mediated dissemination.
Multicenter evaluation of the BIOFIRE Joint Infection Panel for the detection of bacteria, yeast, and AMR genes in synovial fluid samples.
The BIOFIRE Joint Infection Panel demonstrated high sensitivity and specificity for detecting bacteria and antimicrobial resistance (AMR) genes in synovial fluid samples. It effectively identified various AMR genes, including mecA/C and MREJ (MRSA), vanA/B, CTX-M, OXA-48-like, IMP, KPC, NDM, and VIM, in multiple bacterial species.
A global view on carbapenem-resistant Acinetobacter baumannii.
The study identifies and characterizes various carbapenemase genes, including bla OXA-23-like, bla OXA-40-like, bla NDM-1, and bla IMP-26, in carbapenem-resistant Acinetobacter baumannii isolates from diverse geographical regions.
Molecular characteristics and antimicrobial resistance profiles of Carbapenem-Resistant Klebsiella pneumoniae isolates at a tertiary hospital in Nanning, China.
The study identified NDM-1, NDM-5, KPC-2, OXA-181, and IMP-4 as the primary carbapenemase genes in CRKP isolates, with NDM-1 being the most prevalent.
Case Report: Molecular Characterization of Bloodstream Infections due to Carbapenem-Resistant Acinetobacter baumannii: A Pediatric Case Series.
The study identified the presence of carbapenemase genes blaOXA-51, blaOXA-24, and blaIMP in carbapenem-resistant Acinetobacter baumannii bloodstream infections in pediatric patients.
High prevalence of antibiotic resistance and biofilm formation in Salmonella Gallinarum.
The study identified multiple antibiotic resistance genes in Salmonella Gallinarum isolates, including GES, IMP, VIM, NDM, SHV, KPC, FOX, qnrB, qnrS, and sdiA, which are associated with resistance to various antibiotics. Additionally, all isolates were found to form biofilms, indicating a potential link between biofilm formation and antibiotic resistance.
Dissemination and characteristics of carbapenem-resistant Klebsiella pneumoniae in nine district hospitals in southwestern China.
The study identified carbapenem-resistant Klebsiella pneumoniae (CRKP) strains in nine district hospitals in Chongqing, China, with high levels of resistance to carbapenem antibiotics. The primary resistance mechanisms involved carbapenemase production, including bla KPC, bla NDM, and bla IMP genes, as well as co-expression of multiple carbapenemases. The study also highlighted the presence of hypervirulent CRKP (HV-CRKP) strains.
Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics.
The study identified blaIMP-1 as a carbapenem resistance gene in clinical isolates of E. coli and K. pneumoniae, which were multi-drug resistant. Alkyl gallates, particularly octyl gallate (OGA), were shown to inhibit CysE, leading to reduced intrabacterial levels of cysteine and its metabolites, thereby enhancing susceptibility to antibiotics.
Characterisation of meropenem-resistant Bacillus sp. FW 1 isolated from biogas digestate.
The study identifies the carbapenemase gene blaIMP-11 as responsible for meropenem resistance in Bacillus sp. FW 1, and shows that this resistance is not transferable.
Relative inhibitory activities of the broad-spectrum beta-lactamase inhibitor taniborbactam against metallo-beta-lactamases.
The study evaluates the inhibitory activity of taniborbactam against various metallo-beta-lactamases (MBLs), demonstrating that it effectively inhibits most NDM- and VIM-like enzymes but not SIM-1. Specific mutations in VIM-1 and NDM-1 were found to confer resistance to taniborbactam.
Relative inhibitory activities of the broad-spectrum beta-lactamase inhibitor taniborbactam against metallo-beta-lactamases.
The study evaluates the inhibitory activity of taniborbactam against various metallo-beta-lactamases (MBLs), demonstrating that it effectively inhibits most NDM- and VIM-like enzymes but not SIM-1. Specific mutations in VIM-1 and NDM-1 were found to confer resistance to taniborbactam.
Relative inhibitory activities of the broad-spectrum beta-lactamase inhibitor taniborbactam against metallo-beta-lactamases.
The study evaluates the inhibitory activity of taniborbactam against various metallo-beta-lactamases (MBLs), demonstrating that it effectively inhibits most NDM- and VIM-like enzymes but not SIM-1. Specific mutations in VIM-1 and NDM-1 were found to confer resistance to taniborbactam.
Relative inhibitory activities of the broad-spectrum beta-lactamase inhibitor taniborbactam against metallo-beta-lactamases.
The study evaluates the inhibitory activity of taniborbactam against various metallo-beta-lactamases (MBLs), demonstrating that it effectively inhibits most NDM- and VIM-like enzymes but not SIM-1. Specific mutations in VIM-1 and NDM-1 were found to confer resistance to taniborbactam.
The secrets of environmental Pseudomonas aeruginosa in slaughterhouses: Antibiogram profile, virulence, and antibiotic resistance genes.
The study identified multiple antibiotic resistance genes in Pseudomonas aeruginosa isolates from slaughterhouses, including blaCTX-M, blaAmpC, blaSHV, blaNDM, IMP-1, aac(6')-Ib, ant(4')IIb, qnrB, tetA, mexY, TEM, and rmtC. These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, and tetracyclines.
Microbiological profile of patients treated for postoperative peritonitis: temporal trends 1999-2019.
The study identifies the presence of carbapenemase genes (blaVIM, blaKPC, blaOXA-48, blaNDM, and blaIMP) in Escherichia coli isolates, indicating resistance to carbapenems. It also notes an increase in multidrug-resistant Enterobacterales, particularly ESBL-producing strains, over time.
Detection of clinically relevant antibiotic-resistant bacteria in shared fomites, waste water and municipal solid wastes disposed near residential areas of a Nigerian city.
The study identified several antibiotic resistance genes (ARGs) including bla KPC, bla NDM-1, bla CMY-2, and bla IMP in various environmental samples. It also detected two variants of the bla OXA-51-like gene (bla OXA-66 and bla OXA-180) in Acinetobacter baumannii. Additionally, methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL)-producing bacteria were found in sewage, sludge, and shared fomites.
A growing battlefield in the war against biofilm-induced antimicrobial resistance: insights from reviews on antibiotic resistance.
The review discusses various mechanisms of biofilm-induced antimicrobial resistance, including the role of efflux pumps such as AcrAB-TolC, MexAB-OprM, AdeFGH, and AcrD in conferring resistance to multiple classes of antibiotics.
Mechanism for transmission and pathogenesis of carbapenem-resistant Enterobacterales harboring the carbapenemase IMP and clinical countermeasures.
The study identifies blaIMP-4 and blaIMP-26 as carbapenemase genes responsible for carbapenem resistance in Enterobacterales. Additionally, various other AMR genes such as aac(6')-lb3, armAC, aph(3'')-lb, aph(6)-ld, aadA5, aac(6')-llc, aac(3)-IId, dfrA19, dfrA1, sul1, tet(D), tet(A), qnrS1, qnrB4, msr(E), mph(E), ere(A), mph(A), mcr-9, and ARR-3 were characterized for their roles in resistance to different antibiotics.
Mechanism for transmission and pathogenesis of carbapenem-resistant Enterobacterales harboring the carbapenemase IMP and clinical countermeasures.
The study identifies blaIMP-4 and blaIMP-26 as carbapenemase genes responsible for carbapenem resistance in Enterobacterales. Additionally, various other AMR genes such as aac(6')-lb3, armAC, aph(3'')-lb, aph(6)-ld, aadA5, aac(6')-llc, aac(3)-IId, dfrA19, dfrA1, sul1, tet(D), tet(A), qnrS1, qnrB4, msr(E), mph(E), ere(A), mph(A), mcr-9, and ARR-3 were characterized for their roles in resistance to different antibiotics.
Molecular analysis of metallo-beta-lactamase-producing Pseudomonas aeruginosa in Switzerland 2022-2023.
The study identified blaNDM-1, blaIMP-1, and blaVIM-2 as the primary metallo-beta-lactamase genes responsible for resistance in Pseudomonas aeruginosa isolates in Switzerland. These genes conferred resistance to multiple beta-lactam antibiotics and cefiderocol.
Multiplex Microarrays in 96-Well Plates Photoactivated with 4-Azidotetrafluorobenzaldehyde for the Identification and Quantification of beta-lactamase Genes and Their RNA Transcripts.
The study developed a novel microarray technique using photoactivated 96-well plates to identify and quantify beta-lactamase genes and their RNA transcripts. The method successfully detected various beta-lactamase genes, including ESBLs, inhibitor-resistant beta-lactamases, and carbapenemases, demonstrating high specificity and reproducibility.
Evaluation of antimicrobial susceptibility tests for Acinetobacter and Pseudomonas species using disks containing a high dose of meropenem.
The study identified several beta-lactamase genes, including blaIMP-1, blaDIM-1, blaNDM-1, blaVIM-1, blaGES-5, blaOXA-23, blaOXA-51-like, and blaADC, which confer resistance to meropenem in Acinetobacter and Pseudomonas species.
Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing.
The paper discusses the prevalence of antimicrobial resistance in Aeromonas species, highlighting the presence of various beta-lactamase genes such as blaTEM-24, blaIMP-19, blaVIM-4, blaKPC-2, blaNDM-1, blaVIM-2, blaOXA-48, blaIMP-13, blaGES-5, blaTEM-1, blaSHV-12, blaVEB-9, blaMOX, blaFOX, blaACC, and others. It also identifies genes like cphA, vat, mcr-3.41, mcr-7.1, sul, dfr, tetA, rsmA, and adeF associated with resistance to sulfonamides, trimethoprim, tetracycline, polymyxin, and other antibiotics. The study emphasizes the role of horizontal gene transfer and mobile genetic elements in the dissemination of these resistance genes.
Characterization of resistance genes and replicon typing in Carbapenem-resistant Klebsiella pneumoniae strains.
The study identified several beta-lactamase genes, including bla OXA-48, bla SHV, bla TEM, bla CTX-M1, bla CTX-M2, bla IMP, and bla NDM, which contribute to carbapenem resistance in Klebsiella pneumoniae strains. The most prevalent gene was bla OXA-48, found in 96.6% of isolates.
Genomic revisitation and reclassification of the genus Providencia.
The study identifies a novel species, Providencia zhijiangensis, and reveals extensive antibiotic resistance gene (ARG) diversity within the genus, with particular emphasis on carbapenem resistance genes such as blaIMP-27 and blaNDM-1. It also notes the prevalence of aac(2')-Ia, tet(B), and catA3 in P. stuartii, contributing to its multidrug-resistant profile.
Clonal Distribution and Its Association With the Carbapenem Resistance Mechanisms of Carbapenem-Non-Susceptible Pseudomonas aeruginosa Isolates From Korean Hospitals.
Carbapenem resistance in Pseudomonas aeruginosa isolates from Korean hospitals is mainly due to frameshift mutations in the oprD gene, along with the production of metallo-beta-lactamases (blaIMP-6, blaVIM-2, blaNDM-1) or hyperproduction of AmpC beta-lactamase.
Biofilm formation and antimicrobial resistance pattern of uropathogenic E. coli ST131 isolated from children with malignant tumors.
The study identified carbapenem resistance genes blaVIM, blaNDM, blaKPC, and blaIMP in E. coli ST131 isolates, along with biofilm-related genes lasR, pelA, and lecA. ST131 isolates showed higher antimicrobial resistance and biofilm-forming capabilities compared to non-ST131 isolates.
Coexistence of bla(IMP-4) and bla(SFO-1) in an IncHI5B plasmid harbored by tigecycline-non-susceptible Klebsiella variicola strain.
The study reports a tigecycline-non-susceptible Klebsiella variicola strain carrying the blaIMP-4 and blaSFO-1 genes on an IncHI5B plasmid, highlighting the potential for horizontal transfer of these resistance genes.
Prospective observational pilot study of the T2Resistance panel in the T2Dx system for detection of resistance genes in bacterial bloodstream infections.
The T2Resistance panel effectively detected various resistance genes in bacterial bloodstream infections, including bla KPC, bla NDM /bla IMP /bla VIM, bla CTXM-14/15, bla AmpC, and mec A/ mec C, demonstrating high sensitivity and rapid detection times.
Genomic characterization of extended-spectrum beta-lactamase-producing and carbapenem-resistant Escherichia coli from urban wastewater in Australia.
The study identifies multiple AMR genes and mutations in carbapenem-resistant and ESBL-producing E. coli isolates from Australian wastewater, highlighting the presence of resistance mechanisms such as bla NDM-5, bla CMY-42, and mutations in gyrA, parC, and parE.
Clinical and genomic characteristics of IMP-producing Enterobacter cloacae complex and Klebsiella pneumoniae.
The study identifies blaIMP-1 as the sole carbapenemase gene in IMP-producing Enterobacter cloacae complex and Klebsiella pneumoniae isolates, highlighting its prevalence and role in carbapenem resistance.
Prevalence and characteristics of ertapenem-mono-resistant isolates among carbapenem-resistant Enterobacterales in China.
The study identified carbapenemase genes (bla KPC, bla NDM, bla IMP-4, bla OXA-181, and bla VIM-1) and porin mutations contributing to ertapenem-mono-resistance in carbapenem-resistant Enterobacterales (CRE) in China. ETP-mono-resistant CRE strains showed lower carbapenemase positivity and higher susceptibility to certain antibiotics compared to MEM/IPM-resistant strains.
Emergence of pandrug-resistant carbapenemase-producing Enterobacterales in dogs and cats: a cross-sectional study in Egypt.
The study identified multiple carbapenemase genes, including bla_OXA-181, bla_IMP, bla_OXA-48-like, bla_KPC, bla_VIM, and bla_NDM, in carbapenem-resistant Enterobacterales isolated from dogs and cats in Egypt.
Nationwide genome surveillance of carbapenem-resistant Pseudomonas aeruginosa in Japan.
The study identifies blaIMP-98, a novel IMP-type metallo-beta-lactamase variant, as a carbapenem resistance determinant in Pseudomonas aeruginosa isolates from Japan. This gene was functionally validated by cloning and demonstrating increased beta-lactam MICs in E. coli.
Nationwide genome surveillance of carbapenem-resistant Pseudomonas aeruginosa in Japan.
Nationwide genome surveillance of carbapenem-resistant Pseudomonas aeruginosa in Japan.
Chromosomal integration and plasmid fusion occurring in ST20 carbapenem-resistant Klebsiella pneumoniae isolates coharboring bla(NDM-1) and bla(IMP-4) induce resistance transmission and fitness variation.
The study identifies three distinct locations for the bla IMP-4 gene: a separate plasmid, a self-conjugative fusion plasmid, and the bacterial chromosome. Both bla IMP-4 and bla NDM-1 contribute to carbapenem resistance, with bla NDM-1 having a greater impact on resistance and fitness.
First report of the chromosomal integration of carbapenemase gene bla(IMP-19) in Acinetobacter baumannii AB322: the legacy of integron in phage-plasmid?
The study reports the first chromosomal integration of the carbapenemase gene blaIMP-19 in Acinetobacter baumannii AB322, suggesting potential mechanisms involving integrons and phage elements.
Biodiversity of carbapenem-resistant bacteria in clinical samples from the Southwest Amazon region (Rondônia/Brazil).
The study identified various carbapenemase-encoding genes, including bla KPC -like, bla NDM -like, bla OXA-23 -like, bla OXA-58 -like, bla OXA-143 -like, bla OXA-48 -like, bla SPM -like, bla VIM -like, and bla IMP -like, in carbapenem-resistant bacteria from Rondônia, Brazil.
Molecular Epidemiology of Carbapenem-Resistant Klebsiella aerogenes in Japan.
The study identified six carbapenem-resistant K. aerogenes strains harboring carbapenemase genes, including blaIMP-1, blaIMP-6, blaNDM-1, and blaNDM-5. These genes were found to confer resistance to carbapenems.
Molecular Epidemiology of Carbapenem-Resistant Klebsiella aerogenes in Japan.
The study identified six carbapenem-resistant K. aerogenes strains harboring carbapenemase genes, including blaIMP-1, blaIMP-6, blaNDM-1, and blaNDM-5. These genes were found to confer resistance to carbapenems.
Antimicrobial combination effects against multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa strains: A cross-sectional study.
The study identified several beta-lactamase genes, including bla OXA-23, bla OXA-58, bla OXA-48, bla VIM, bla IMP, and bla NDM, which confer resistance to carbapenems in multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa strains.
Emergence of carbapenem-resistant Pseudomonas aeruginosa ST179 producing both IMP-16 and KPC-2: a case study of introduction from Peru to Spain.
The study reports the emergence of carbapenem-resistant Pseudomonas aeruginosa ST179 carrying blaIMP-16, blaKPC-2, and blaKPC-35 genes, highlighting the global threat of multidrug-resistant clones and the importance of monitoring resistance mechanisms.
Potential involvement of beta-lactamase homologous proteins in resistance to beta-lactam antibiotics in gram-negative bacteria of the ESKAPEE group.
The study identifies and characterizes beta-lactamase homologous proteins in gram-negative bacteria of the ESKAPEE group, highlighting their potential role in resistance to beta-lactam antibiotics.
The Rising Tide of Antibiotic Resistance: A Study on Extended-Spectrum Beta-Lactamase and Carbapenem-Resistant Escherichia coli and Klebsiella pneumoniae.
The study identifies the presence of extended-spectrum beta-lactamase (ESBL)-producing and carbapenem-resistant Enterobacterales, specifically Escherichia coli and Klebsiella pneumoniae, in clinical settings in Pakistan. Key resistance genes include bla CTX-M, bla TEM, bla SHV, bla NDM, bla VIM, and bla IMP.
Investigation of genotyping and phenotyping characteristics of carbapenem-resistant Klebsiella pneumoniae isolates.
The study identified blaOXA-48, blaIMP, and blaNDM genes as the primary carbapenem resistance mechanisms in carbapenem-resistant Klebsiella pneumoniae isolates.
Molecular characterization and epidemiological investigation of colistin resistance in carbapenem-resistant Klebsiella pneumoniae in a tertiary care hospital in Tehran, Iran.
The study identified mcr-1 as a cause of colistin resistance in CRKP isolates and characterized multiple carbapenemase genes, including bla OXA−48, bla KPC, bla VIM, bla IMP, and bla NDM.
Comparative genomics of Tn6411 transposons carrying the blaIMP-1 gene in Pseudomonas aeruginosa.
The study identifies the presence of the blaIMP-1 gene within the Tn6411 transposon in Pseudomonas aeruginosa strains, along with aacC2 and catB7, contributing to resistance against carbapenems, aminoglycosides, and chloramphenicol.
Emergence of Carbapenem-resistant Clinical Isolates of Providencia Species.
The study identifies blaIMP-70, blaIMP-1, and blaIMP-11 as carbapenem resistance genes in Providencia species isolates, along with aac(6')-Ib4 and aac(6')-Iae for aminoglycoside resistance. Mutations in gyrA and parC contribute to quinolone resistance.
Emergence of Carbapenem-resistant Clinical Isolates of Providencia Species.
The study identifies blaIMP-70, blaIMP-1, and blaIMP-11 as carbapenem resistance genes in Providencia species isolates, along with aac(6')-Ib4 and aac(6')-Iae for aminoglycoside resistance. Mutations in gyrA and parC contribute to quinolone resistance.
Emergence of Carbapenem-resistant Clinical Isolates of Providencia Species.
The study identifies blaIMP-70, blaIMP-1, and blaIMP-11 as carbapenem resistance genes in Providencia species isolates, along with aac(6')-Ib4 and aac(6')-Iae for aminoglycoside resistance. Mutations in gyrA and parC contribute to quinolone resistance.
Genomic analysis of carbapenem- and colistin-resistant Klebsiella pneumoniae complex harbouring mcr-8 and mcr-9 from individuals in Thailand.
The study identifies mcr-8 and mcr-9 genes in carbapenem-resistant Klebsiella pneumoniae complex isolates from Thailand, highlighting their role in colistin resistance. It also characterizes additional AMR genes such as bla NDM-1, bla IMP-14, and various other resistance determinants.
Coexistence of a novel NDM-1-encoding MDR plasmid and an IMP-4-encoding IncN-IncU hybrid plasmid in a clinical isolate of Citrobacter freundii BC73.
The study identifies a novel MDR plasmid carrying blaNDM-1 and an IncN-IncU hybrid plasmid carrying blaIMP-4 in a clinical isolate of Citrobacter freundii BC73, highlighting the coexistence of multiple carbapenemase genes and their potential for horizontal gene transfer.
Three prolonged outbreaks of metallo-β-lactamase-producing Pseudomonas aeruginosa in an Upper Austrian hospital, 2017-2023.
The study identified three distinct genomic clusters of metallo-beta-lactamase-producing Pseudomonas aeruginosa (MBL-Pa) in an Austrian hospital, linked to prolonged outbreaks. Key resistance genes included blaVIM-2, blaVIM-1, and blaIMP-13, which conferred resistance to carbapenems, cephalosporins, and penicillins.
Coexistence of plasmid-mediated tmexCD2-toprJ2, bla(IMP-4), and bla(NDM-1) in Klebsiella quasipneumoniae.
The study identifies the coexistence of plasmid-mediated tmexCD2-toprJ2, blaIMP-4, and blaNDM-1 in Klebsiella quasipneumoniae strain FK8966, highlighting the emergence of multidrug-resistant strains with resistance to tigecycline and carbapenems.
Evaluation of the Xpert Carba-R assay for quantifying carbapenemase-producing bacterial load in stool samples.
The study evaluated the Xpert Carba-R assay for quantifying carbapenemase-producing bacterial load in stool samples, demonstrating the ability to estimate bacterial loads for bla NDM, bla KPC, and bla OXA-48 with acceptable accuracy, while bla IMP-1 and bla VIM showed higher limits of detection.
In vitro Synergistic and Bactericidal Effects of Aztreonam in Combination with Ceftazidime/ Avibactam, Meropenem/Vaborbactam and Imipenem/Relebactam Against Dual-Carbapenemase-Producing Enterobacterales.
The study identified multiple carbapenemase genes, including bla KPC-2, bla NDM-1, bla NDM-5, bla IMP-26, and bla IMP-4, in dual-carbapenemase-producing Enterobacterales. These genes conferred resistance to carbapenems and other beta-lactam antibiotics. The combinations of aztreonam with ceftazidime/avibactam, meropenem/vaborbactam, and imipenem/relebactam showed synergistic and bactericidal effects against these strains.
In vitro Synergistic and Bactericidal Effects of Aztreonam in Combination with Ceftazidime/ Avibactam, Meropenem/Vaborbactam and Imipenem/Relebactam Against Dual-Carbapenemase-Producing Enterobacterales.
The study identified multiple carbapenemase genes, including bla KPC-2, bla NDM-1, bla NDM-5, bla IMP-26, and bla IMP-4, in dual-carbapenemase-producing Enterobacterales. These genes conferred resistance to carbapenems and other beta-lactam antibiotics. The combinations of aztreonam with ceftazidime/avibactam, meropenem/vaborbactam, and imipenem/relebactam showed synergistic and bactericidal effects against these strains.
Impact of AbaI mutation on virulence, biofilm development, and antibiotic susceptibility in Acinetobacter baumannii.
The study shows that the abaI gene deletion in Acinetobacter baumannii leads to increased susceptibility to several antibiotics, including imipenem, meropenem, gentamicin, kanamycin, tetracycline, and vancomycin, despite the upregulation of metallo-beta-lactamase (MBL) superfamily proteins and DcaP-like protein. The findings suggest that the abaI gene plays a significant role in modulating antibiotic resistance and virulence in A. baumannii.
Characterization of pKPN945B, a novel transferable IncR plasmid from hypervirulent carbapenem-resistant Klebsiella pneumoniae, harboring bla(IMP-4) and qnrS1.
The study characterizes a novel transferable IncR plasmid, pKPN945B, from a hypervirulent carbapenem-resistant Klebsiella pneumoniae strain, KPN945, which harbors the bla(IMP-4) and qnrS1 genes.
Cefepime-taniborbactam activity against antimicrobial-resistant clinical isolates of Enterobacterales and Pseudomonas aeruginosa: GEARS global surveillance programme 2018-22.
Cefepime-taniborbactam showed potent in vitro activity against Enterobacterales and P. aeruginosa, particularly effective against isolates with carbapenemase genes such as blaIMP, blaNDM, and blaVIM, as well as those with mutations in ftsI, ompK35, and ompK36.
Evaluation of an expanded antibiotic resistance gene panel on prediction of antimicrobial susceptibility results for Gram-negative bacteria in blood cultures.
The study evaluated the QIAstat-Dx BCID panel for detecting antibiotic resistance genes in Gram-negative bacteria from blood cultures. It found that the panel effectively identified several resistance genes, including bla CTX-M, bla KPC, bla NDM, and others, which are crucial for predicting antimicrobial susceptibility. The panel showed high sensitivity and specificity for identifying resistance genes and predicting susceptibility, especially for beta-lactam antibiotics.
Molecular epidemiology and carbapenem resistance mechanisms of Pseudomonas aeruginosa isolated from a hospital in Fujian, China.
The study identifies several carbapenem resistance mechanisms in Pseudomonas aeruginosa, including carbapenemase genes (blaIMP, blaVIM, blaNDM, blaKPC), mutations in the outer membrane porins oprD and opdP, and overexpression of multidrug efflux pumps.
Molecular epidemiology and carbapenem resistance mechanisms of Pseudomonas aeruginosa isolated from a hospital in Fujian, China.
The study identifies several carbapenem resistance mechanisms in Pseudomonas aeruginosa, including carbapenemase genes (blaIMP, blaVIM, blaNDM, blaKPC), mutations in the outer membrane porins oprD and opdP, and overexpression of multidrug efflux pumps.
Antimicrobial susceptibility to last-resort antibiotics in carbapenemase-producing bacteria from Ukrainian patients.
The study identified multiple carbapenemase genes, including blaNDM, blaOXA-48, blaKPC, blaIMP, blaVIM, and blaGES, which confer resistance to last-resort antibiotics in carbapenemase-producing bacteria from Ukrainian patients.
Predominance of bla(NDM)- and bla(IMP)-Harboring Escherichia coli Belonging to Clonal Complexes 131 and 23 in a Major University Hospital.
The study identifies the prevalence of carbapenem-resistant E. coli (CR-EC) in a major university hospital, highlighting the dominance of bla(NDM) and bla(IMP) genes, along with other resistance genes such as bla(OXA-48), bla(CTX-M15), bla(TEM), armA, and rmtB. The most prevalent sequence types were ST131 and ST2279, with bla(NDM) primarily associated with ST131 complex.
The enhanced antibacterial and antibiofilm properties of titanium dioxide nanoparticles biosynthesized by multidrug-resistant Pseudomonas aeruginosa.
The study identified the blaOXA-48 gene as the most prevalent carbapenemase gene in multidrug-resistant Pseudomonas aeruginosa isolates, contributing to carbapenem resistance.
Blood-rsCDM: a new rapid and simplified carbapenemase detection method for detecting carbapenemases in Enterobacterales directly from positive blood cultures.
The study presents a new rapid and simplified method, Blood-rsCDM, for detecting and characterizing carbapenemases in Enterobacterales directly from positive blood cultures. It effectively identifies various carbapenemase types, including KPC, NDM, IMP, VIM, and OXA-181, with high sensitivity and specificity.
Critical resistance to carbapenem and aminoglycosides in Pseudomonas aeruginosa: spread of bla(NDM)/16S methylase armA harboring isolates with intrinsic resistance mechanisms in Kerman, Iran.
The study identified multiple carbapenemase genes (bla_NDM, bla_IMP, bla_VIM, bla_SIM, bla_GES) and the 16S rRNA methylase gene armA in carbapenem-resistant Pseudomonas aeruginosa isolates from Kerman, Iran. These genes contribute to resistance against carbapenems and aminoglycosides, highlighting the complex resistance mechanisms in these isolates.
High prevalence of carbapenem-resistant Enterobacter cloacae complex in a tertiary hospital over a decade.
The study identified blaNDM-1, blaNDM-5, blaIMP-4, and blaKPC-2 as the main carbapenem resistance genes in carbapenem-resistant Enterobacter cloacae complex (CRECC) isolates. Additionally, various extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase genes were detected, contributing to multidrug resistance.
Myroides species, pathogenic spectrum and clinical microbiology sight in Mexican isolates.
The study identified multiple AMR genes in Myroides spp. isolates, including beta-lactamases (blaIMP-27, blaIMP-35, blaGOB-16, blaMUS-1, blaOXA-229, blaOXA-351, blaOXA-97), erythromycin esterase (ereB), and polymyxin resistance genes (mcr-3.6, mcr-3.7, mcr-3.10), indicating a high level of multidrug resistance.
Myroides species, pathogenic spectrum and clinical microbiology sight in Mexican isolates.
The study identified multiple AMR genes in Myroides spp. isolates, including beta-lactamases (blaIMP-27, blaIMP-35, blaGOB-16, blaMUS-1, blaOXA-229, blaOXA-351, blaOXA-97), erythromycin esterase (ereB), and polymyxin resistance genes (mcr-3.6, mcr-3.7, mcr-3.10), indicating a high level of multidrug resistance.
Myroides species, pathogenic spectrum and clinical microbiology sight in Mexican isolates.
The study identified multiple AMR genes in Myroides spp. isolates, including beta-lactamases (blaIMP-27, blaIMP-35, blaGOB-16, blaMUS-1, blaOXA-229, blaOXA-351, blaOXA-97), erythromycin esterase (ereB), and polymyxin resistance genes (mcr-3.6, mcr-3.7, mcr-3.10), indicating a high level of multidrug resistance.
The characterization of an IncN-IncR fusion plasmid co-harboring bla(TEM-40), bla(KPC-2), and bla(IMP-4) derived from ST1393 Klebsiella pneumoniae.
The study characterizes a novel IncN-IncR fusion plasmid carrying bla(KPC-2), bla(IMP-4), and bla(TEM-40) genes, along with qnrS1, in a ST1393 Klebsiella pneumoniae strain. The plasmid was found to confer resistance to multiple carbapenems and other antibiotics.
Functional and structural analyses of IMP-27 metallo-β-lactamase: evolution of IMP-type enzymes to overcome Zn(II) deprivation.
IMP-27 is a metallo-beta-lactamase that shows high resistance to meropenem. The G262S mutation improves its catalytic efficiency against several beta-lactam antibiotics.
Prevalence of bla(OXA-48) and other carbapenemase encoding genes among carbapenem-resistant Pseudomonas aeruginosa clinical isolates in Egypt.
The study identified blaVIM, blaOXA-48, blaKPC, blaIMP, blaGES, and blaNDM as prevalent carbapenemase encoding genes among carbapenem-resistant P. aeruginosa isolates in Egypt. blaOXA-48 was frequently associated with the Tn1999 transposon.
Carbapenemase-producing bacteria recovered from Nairobi River, Kenya surface water and from nearby anthropogenic and zoonotic sources.
The study identified multiple carbapenemase-encoding genes, including bla NDM, bla KPC, bla VIM, bla OXA-48-like, bla IMP, and bla GES, in various bacterial species from Nairobi River and surrounding environments.
Molecular characteristics and antibiotic resistance mechanisms of multidrug-resistant Pseudomonas aeruginosa in Nanning, China.
The study identified NDM-1, IMP-9, VIM-2, and KPC-2 carbapenemase genes as major contributors to multidrug resistance in Pseudomonas aeruginosa strains in Nanning, China.
Antimicrobial Resistance in Acinetobacter baumannii and Carbapenem-Resistant Enterobacteriaceae
The paper discusses the mechanisms of carbapenem resistance in various bacterial species, highlighting the roles of beta-lactamases such as KPC, NDM, VIM, IMP, and OXA-48. These genes are plasmid-encoded and facilitate horizontal gene transfer, contributing to multidrug resistance.
Identification and characterisation of colistin-resistant Acinetobacter colistiniresistens co-producing IMP-1 and OXA-58 carbapenemases.
The study identifies and characterizes a colistin-resistant Acinetobacter colistiniresistens isolate co-producing IMP-1 and OXA-58 carbapenemases. The isolate exhibits resistance to multiple antibiotics, including carbapenems, cephalosporins, and polymyxins, and harbors several resistance genes such as blaIMP-1, blaOXA-58, and eptA-like, which contribute to its multidrug-resistant phenotype.
Performance of a hybrid capture-based target enrichment next-generation sequencing for the identification of respiratory pathogens and resistance-associated genes in patients with severe pneumonia.
The study evaluated the performance of RPIP for detecting respiratory pathogens and AMR genes in patients with severe pneumonia. RPIP showed superior sensitivity in detecting bacteria, viruses, and fungi compared to FilmArray-PN and culture methods. It identified several AMR genes, including bla CTX-M, bla OXA, bla CMY, bla OXA, bla SHV, bla IMP, bla NDM, and mec A/C & MREJ, which confer resistance to various antibiotics.
Optimized methods for the targeted surveillance of extended-spectrum beta-lactamase-producing Escherichia coli in human stool.
The study identifies and characterizes the resistance mechanisms of ESBL-producing E. coli, focusing on the blaCTX-M-15, blaIMP, and blaCTX-M-27 genes, demonstrating their role in conferring resistance to various beta-lactam antibiotics.
The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes.
The study characterizes various resistance genes carried by incompatible plasmids in Gram-negative bacteria, highlighting their role in the spread of antibiotic resistance. Key genes include beta-lactamases like bla VIM-1, bla SHV-12, bla TEM-1B, and bla CTX-M-15, as well as sulfonamide resistance genes sul1 and sul2, tetracycline resistance gene tetA, and polymyxin resistance gene mcr-1.
Molecular Epidemiology and Clinical Characterization of Carbapenemase-Producing Enterobacter Species From an International Cohort.
The study identifies bla KPC, bla NDM, bla IMP, bla IMI, and bla VIM as the primary carbapenemase genes in carbapenemase-producing Enterobacter species, along with fluoroquinolone resistance mutations in gyrA and parC, and porin gene mutations in ompF and ompC.
Phenotypic and genotypic characterization of clinical carbapenem-resistant Acinetobacter species harboring the metallo-beta-lactamases IMP-8 or NDM-1 in China.
The study characterized the phenotypic and genotypic features of one IMP-8-producing and four NDM-1-producing plasmids in Acinetobacter spp. strains isolated in 2010, highlighting the presence of various resistance genes including blaIMP-8, blaNDM-1, aac(6')-Ib, aac(3)-IId, msr(E), mph(E), sul1, sul2, tet(39), and aph(3')-VI.
Import of global high-risk clones is the primary driver of carbapenemase-producing Pseudomonas aeruginosa in Norway.
The study identifies the emergence of carbapenemase-producing Pseudomonas aeruginosa in Norway, primarily linked to international travel and hospitalization, highlighting the importance of genomic surveillance and infection control measures.
National Multicenter Study on the Prevalence of Carbapenemase-Producing Enterobacteriaceae in the Post-COVID-19 Era in Argentina: The RECAPT-AR Study.
The study identified bla NDM, bla KPC, and bla OXA-163 as the main carbapenemase genes in Enterobacterales isolates from Argentina, with NDM and KPC being the most prevalent.
Phenotypic identification of Metallo-ß- lactamase resistance Gram negative bacteria from a clinical specimen in Sidama, Ethiopia.
The study identified the presence of metallo-beta-lactamase (MBL) resistance in various Gram-negative bacteria, including Klebsiella pneumonia, Escherichia coli, Acinetobacter spp., and Pseudomonas spp. The highest prevalence of MBL resistance was observed in Enterobacteriaceae, followed by Acinetobacter spp. and Pseudomonas spp.
Emerging carbapenem-resistant Klebsiella pneumoniae in a tertiary care hospital in Lima, Peru.
The study identifies blaNDM-1, blaKPC-2, and blaIMP-74 as the primary carbapenem resistance genes in CRKP isolates from Lima, Peru. Additionally, aac(6')-Ib and sul1 were found to confer resistance to aminoglycosides and sulfonamides, respectively.
Clinical evaluation of a multiplex droplet digital PCR for diagnosing suspected bloodstream infections: a prospective study.
The study evaluated a multiplex droplet digital PCR (ddPCR) assay for diagnosing bloodstream infections, identifying key AMR genes such as bla KPC, bla NDM, bla VIM, bla IMP, bla OXA48, vanA, vanM, and mecA in clinical isolates.
Genomic characteristics of ST6115 carbapenem-resistant Klebsiella pneumoniae coharboring bla (NDM-1) and bla (IMP-4).
The study identifies the coexistence of blaNDM-1 and blaIMP-4 in the IncHI5 plasmid pHD8428-NDM-IMP in a clinical ST6115 strain, highlighting the potential for horizontal gene transfer and the spread of carbapenem resistance.
Combating Metallo-β-Lactamase-Producing Pseudomonas aeruginosa: The Fractional Inhibitory Concentration Index as a Tool to Evaluate Antibiotic Synergy.
The study identified blaIMP-13 and blaVIM-2 as resistance genes in multidrug-resistant P. aeruginosa isolates, demonstrating the effectiveness of cefiderocol combined with imipenem-relebactam against IMP-producing strains.
Rapid prediction of carbapenemases in Pseudomonas aeruginosa by imipenem/relebactam and MALDI-TOF MS.
The study characterizes various carbapenemase genes such as blaIMP-13, blaIMP-94, blaNDM-1, blaNDM-5, blaNDM-7, blaNDM-23, blaVIM-1, blaVIM-2, blaVIM-20, blaKPC-2, blaKPC-3, blaGES-1, blaGES-5, blaGES-7, blaGES-20, blaPER-1, blaVEB-1, blaCTX-M-15, blaCTX-M-9, blaSHV-12, blaFOX-4, blaCMY-2, blaDHA-1, blaOXA-2, blaOXA-10, blaOXA-14, blaOXA-15, and blaOXA-48 in Pseudomonas aeruginosa using MALDI-TOF MS hydrolysis assays.
Rapid prediction of carbapenemases in Pseudomonas aeruginosa by imipenem/relebactam and MALDI-TOF MS.
The study characterizes various carbapenemase genes such as blaIMP-13, blaIMP-94, blaNDM-1, blaNDM-5, blaNDM-7, blaNDM-23, blaVIM-1, blaVIM-2, blaVIM-20, blaKPC-2, blaKPC-3, blaGES-1, blaGES-5, blaGES-7, blaGES-20, blaPER-1, blaVEB-1, blaCTX-M-15, blaCTX-M-9, blaSHV-12, blaFOX-4, blaCMY-2, blaDHA-1, blaOXA-2, blaOXA-10, blaOXA-14, blaOXA-15, and blaOXA-48 in Pseudomonas aeruginosa using MALDI-TOF MS hydrolysis assays.
Rapid prediction of carbapenemases in Pseudomonas aeruginosa by imipenem/relebactam and MALDI-TOF MS.
The study characterizes various carbapenemase genes such as blaIMP-13, blaIMP-94, blaNDM-1, blaNDM-5, blaNDM-7, blaNDM-23, blaVIM-1, blaVIM-2, blaVIM-20, blaKPC-2, blaKPC-3, blaGES-1, blaGES-5, blaGES-7, blaGES-20, blaPER-1, blaVEB-1, blaCTX-M-15, blaCTX-M-9, blaSHV-12, blaFOX-4, blaCMY-2, blaDHA-1, blaOXA-2, blaOXA-10, blaOXA-14, blaOXA-15, and blaOXA-48 in Pseudomonas aeruginosa using MALDI-TOF MS hydrolysis assays.
Emergence of Tigecycline-Nonsusceptible Carbapenem-Resistant Klebsiella pneumoniae with Metallo-β-Lactamase and Transferable Ceftazidime-Avibactam Resistance in China.
The study identifies multiple AMR genes and mutations in MBL-CRKP strains, including blaIMP-4, blaNDM-1, blaNDM-29, and tmexCD2-toprJ2, which confer resistance to carbapenems, CZA, and tigecycline. Mutations in rpsJ, tet(A), ompK35, and ompK36, along with upregulation of efflux pump genes, contribute to tigecycline resistance.
Impact of the Technical Snow Production Process on Bacterial Community Composition, Antibacterial Resistance Genes, and Antibiotic Input-A Dual Effect of the Inevitable.
The study identified several antibiotic resistance genes (ARGs) in water and snow samples from ski resorts, including blaTEM, blaCTX-M, mecA, ereA, ermB, strA, tetK, and sulIII. These genes were associated with resistance to beta-lactams, macrolides, aminoglycosides, tetracyclines, and sulfonamides. The presence of these ARGs highlights the potential environmental impact of technical snow production on antimicrobial resistance.
Spectrum of cefepime-taniborbactam coverage against 190 β-lactamases defined in engineered isogenic Escherichia coli strains.
Spectrum of cefepime-taniborbactam coverage against 190 β-lactamases defined in engineered isogenic Escherichia coli strains.
Spectrum of cefepime-taniborbactam coverage against 190 β-lactamases defined in engineered isogenic Escherichia coli strains.
The importance of monitoring a new antibiotic: ceftazidime/avibactam usage and resistance experience from England, 2016 to 2020.
The study identified the presence of ceftazidime/avibactam resistance in Enterobacterales in England, with nearly 90% of resistance cases associated with metallo-beta-lactamase (MBL) genes such as bla KPC, bla OXA-48-like, bla NDM, bla VIM, and bla IMP. These genes were experimentally validated as conferring resistance to ceftazidime/avibactam.
Diagnostic algorithm for the detection of carbapenemases and extended-spectrum β-lactamases in carbapenem-resistant Pseudomonas aeruginosa.
The study identifies several carbapenemase and extended-spectrum beta-lactamase genes, including bla(VIM-2), bla(VIM-4), bla(IMP-1), bla(NDM-1), bla(GES-5), and bla(KPC-2), which confer resistance to carbapenems and other beta-lactam antibiotics in carbapenem-resistant Pseudomonas aeruginosa.
Diagnostic algorithm for the detection of carbapenemases and extended-spectrum β-lactamases in carbapenem-resistant Pseudomonas aeruginosa.
The study identifies several carbapenemase and extended-spectrum beta-lactamase genes, including bla(VIM-2), bla(VIM-4), bla(IMP-1), bla(NDM-1), bla(GES-5), and bla(KPC-2), which confer resistance to carbapenems and other beta-lactam antibiotics in carbapenem-resistant Pseudomonas aeruginosa.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Comparison of CRISPR-Cas9, CRISPR-Cas12f1, and CRISPR-Cas3 in eradicating resistance genes KPC-2 and IMP-4.
The study demonstrates that CRISPR-Cas9, CRISPR-Cas12f1, and CRISPR-Cas3 can effectively eradicate the carbapenem resistance genes KPC-2 and IMP-4 in E. coli, restoring bacterial susceptibility to antibiotics.
REL/DPA/AVI method: a novel approach for rapid detection of carbapenemase-producing Enterobacterales directly from positive blood cultures based on optical density.
The REL/DPA/AVI method was developed for rapid detection of carbapenemase-producing Enterobacterales directly from positive blood cultures. It showed high sensitivity and specificity for detecting class A, B, and D carbapenemases, with improved time efficiency compared to traditional methods.
Evaluation of multidrug-resistant bacteria and their molecular mechanisms found in small animal veterinary practices in Portugal.
The study identified carbapenem-resistant bacteria, including OXA-23-producing Acinetobacter spp. and IMP-8-producing Pseudomonas juntendi, along with mutations in the oprD, nalC, and mexR genes contributing to carbapenem resistance in Pseudomonas aeruginosa strains.
Inhibitory activity of meso-dimercaptosuccinic acid against IMP metallo-β-lactamase variants in Pseudomonas aeruginosa.
The study identifies that meso-dimercaptosuccinic acid (DMSA) enhances the efficacy of ceftazidime (CAZ) and cefepime (FEP) against IMP-producing Pseudomonas aeruginosa by inhibiting IMP metallo-β-lactamase variants, demonstrating significant synergistic effects.
Inhibitory activity of meso-dimercaptosuccinic acid against IMP metallo-β-lactamase variants in Pseudomonas aeruginosa.
The study identifies that meso-dimercaptosuccinic acid (DMSA) enhances the efficacy of ceftazidime (CAZ) and cefepime (FEP) against IMP-producing Pseudomonas aeruginosa by inhibiting IMP metallo-β-lactamase variants, demonstrating significant synergistic effects.
Inhibitory activity of meso-dimercaptosuccinic acid against IMP metallo-β-lactamase variants in Pseudomonas aeruginosa.
The study identifies that meso-dimercaptosuccinic acid (DMSA) enhances the efficacy of ceftazidime (CAZ) and cefepime (FEP) against IMP-producing Pseudomonas aeruginosa by inhibiting IMP metallo-β-lactamase variants, demonstrating significant synergistic effects.
Molecular characterization of carbapenem resistance mechanisms and phenotypic correlations in clinical Klebsiella pneumoniae isolates from Ningbo, China.
The study identifies KPC-2, NDM-5, IMP-4, OXA-232, and OXA-181 as the main carbapenemase genes in CRKP isolates from Ningbo, China. It also highlights the prevalence of CTX-M-14, SHV-11, and SHV-12 beta-lactamase genes.
Carbapenem-resistance in Acinetobacter baumannii: prevalence, antibiotic resistance profile and carbapenemase genes in clinical and hospital environmental strains.
The study identified bla KPC, bla VIM, and bla IMP carbapenemase genes in Acinetobacter baumannii isolates from clinical and hospital environmental samples, highlighting the prevalence of multidrug-resistant strains and the importance of monitoring carbapenem resistance.
The rise and global spread of IMP carbapenemases (1996-2023): a genomic epidemiology study.
The study identifies 52 bla IMP variants, highlighting their global spread and the role of plasmids and mobile genetic elements in their dissemination. Key variants like bla IMP-1, bla IMP-4, and bla IMP-27 achieved global or regional endemicity, emphasizing the need for integrated strategies to combat their spread.
The rise and global spread of IMP carbapenemases (1996-2023): a genomic epidemiology study.
The study identifies 52 bla IMP variants, highlighting their global spread and the role of plasmids and mobile genetic elements in their dissemination. Key variants like bla IMP-1, bla IMP-4, and bla IMP-27 achieved global or regional endemicity, emphasizing the need for integrated strategies to combat their spread.
The rise and global spread of IMP carbapenemases (1996-2023): a genomic epidemiology study.
The study identifies 52 bla IMP variants, highlighting their global spread and the role of plasmids and mobile genetic elements in their dissemination. Key variants like bla IMP-1, bla IMP-4, and bla IMP-27 achieved global or regional endemicity, emphasizing the need for integrated strategies to combat their spread.
The rise and global spread of IMP carbapenemases (1996-2023): a genomic epidemiology study.
The study identifies 52 bla IMP variants, highlighting their global spread and the role of plasmids and mobile genetic elements in their dissemination. Key variants like bla IMP-1, bla IMP-4, and bla IMP-27 achieved global or regional endemicity, emphasizing the need for integrated strategies to combat their spread.
The rise and global spread of IMP carbapenemases (1996-2023): a genomic epidemiology study.
The study identifies 52 bla IMP variants, highlighting their global spread and the role of plasmids and mobile genetic elements in their dissemination. Key variants like bla IMP-1, bla IMP-4, and bla IMP-27 achieved global or regional endemicity, emphasizing the need for integrated strategies to combat their spread.
The rise and global spread of IMP carbapenemases (1996-2023): a genomic epidemiology study.
The study identifies 52 bla IMP variants, highlighting their global spread and the role of plasmids and mobile genetic elements in their dissemination. Key variants like bla IMP-1, bla IMP-4, and bla IMP-27 achieved global or regional endemicity, emphasizing the need for integrated strategies to combat their spread.
The rise and global spread of IMP carbapenemases (1996-2023): a genomic epidemiology study.
The study identifies 52 bla IMP variants, highlighting their global spread and the role of plasmids and mobile genetic elements in their dissemination. Key variants like bla IMP-1, bla IMP-4, and bla IMP-27 achieved global or regional endemicity, emphasizing the need for integrated strategies to combat their spread.
The rise and global spread of IMP carbapenemases (1996-2023): a genomic epidemiology study.
The study identifies 52 bla IMP variants, highlighting their global spread and the role of plasmids and mobile genetic elements in their dissemination. Key variants like bla IMP-1, bla IMP-4, and bla IMP-27 achieved global or regional endemicity, emphasizing the need for integrated strategies to combat their spread.
Nationwide surveillance of carbapenem-resistant Gram-negative pathogens in the Lebanese environment.
The study identified carbapenem-resistant Gram-negative bacteria in various environmental samples in Lebanon, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Key resistance genes detected include bla NDM-5, bla OXA-23, bla OXA-66, mexAB-OprM, bla IMP-1, and others, highlighting the widespread presence of carbapenem resistance in the environment.
Detection of β-lactam resistance genes in Gram-negative bacteria from positive blood cultures using a microchip-based molecular assay.
The study evaluated the Alifax GNR microchip assay for detecting β-lactam resistance genes in Gram-negative bacteria from positive blood cultures, demonstrating high accuracy and broader coverage compared to existing methods.
Establishing Clinical and Laboratory Standards Institute M45 antimicrobial susceptibility testing methods and breakpoints for Pseudomonas other than Pseudomonas aeruginosa.
The study established tentative CLSI M45 antimicrobial susceptibility testing breakpoints for Pseudomonas other than Pseudomonas aeruginosa (POPA). It identified various beta-lactamase genes, including metallo-beta-lactamases (MBLs) such as bla POM-1, bla POM-2, bla PAM-1, bla PST-1, bla VIM-2, bla CARB-2, bla DHA-1, and bla IMP-13, which confer resistance to carbapenems. Additionally, multidrug-resistant efflux pumps like ttgABC and tmexCD-toprJ were found to contribute to carbapenem resistance. Other resistance genes for aminoglycosides, trimethoprim-sulfamethoxazole, quaternary ammonium compounds, chloramphenicol, and fluoroquinolones were also detected.
Analysis of clinical characteristics of patients with coronavirus disease 2019 based on a superior carbapenem-resistant Enterobacterales identification strategy.
The study evaluated the performance of GeneXpert Carba-R and immunochromatography for detecting carbapenemases in 115 gram-negative isolates, focusing on bla KPC, bla NDM, bla OXA-48, bla IMP, and bla VIM genes. It highlighted the importance of accurate detection of carbapenemase-producing Enterobacterales to guide antibiotic treatment in patients with COVID-19.
Validation of immunochromatographic test in broth-enriched rectal swab specimens.
The study validated the O.K.N.V.I. RESIST-5 immunochromatographic test for detecting five common carbapenemases (KPC, NDM, OXA-48, VIM, and IMP) in broth-enriched rectal swabs with 100% sensitivity and specificity after 6 hours of incubation without meropenem.
Tracing the evolutionary trajectory of the IncP-2 plasmid co-harboring bla (IMP-45) and bla (VIM-1): an outbreak of Pseudomonas aeruginosa co-producing IMP-45 and VIM-1 carbapenemases in China.
The study documents an outbreak of P. aeruginosa co-producing VIM-1 and IMP-45 carbapenemases in a tertiary hospital in China, highlighting the emergence of highly resistant strains among transplant patients.
Molecular epidemiology and clinical characteristics of carbapenem-resistant Klebsiella pneumoniae bloodstream and pneumonia isolates.
The study identified various carbapenemase genes (blaKPC-2, blaKPC-3, blaOXA-181, blaOXA-232, blaOXA-48, blaNDM-1, blaNDM-4, blaNDM-7, blaIMP-1) and extended-spectrum beta-lactamase genes (ampC, ctx-M-15, shv-9) in carbapenem-resistant Klebsiella pneumoniae isolates. Additionally, mutations in porin genes ompK35 and ompK36 were found to contribute to carbapenem resistance in isolates lacking carbapenemases.
The impact of zinc supplementation on carbapenem MICs among bacteria expressing IMP metallo-beta-lactamase.
Zinc supplementation did not affect carbapenem MICs in bacteria expressing blaIMP, suggesting that additional zinc is not necessary for accurate MIC determination.
Evolution of XDR Pseudomonas aeruginosa ST463 strains with two plasmids harboring multiple antimicrobial resistance genes.
The study identifies multiple antimicrobial resistance genes, including blaIMP-45, blaAFM-1, and blaKPC-2, in XDR Pseudomonas aeruginosa ST463 strains, highlighting their role in carbapenem resistance.
Carbapenem-Resistant Gram-Negative Bacteria in Hospitalized Patients: A Five-Year Surveillance in Italy.
The study identifies the presence of carbapenem-resistant Klebsiella pneumoniae isolates carrying bla KPC, bla NDM, bla VIM, and bla IMP genes, which confer resistance to carbapenems.
The genetic context of blaIMP varies among bacterial families from One Health sources.
The study identifies blaIMP-27, blaIMP-64, and blaIMP-95 genes in various bacterial isolates from One Health sources, highlighting their genetic contexts and mobility mechanisms.
The genetic context of blaIMP varies among bacterial families from One Health sources.
The study identifies blaIMP-27, blaIMP-64, and blaIMP-95 genes in various bacterial isolates from One Health sources, highlighting their genetic contexts and mobility mechanisms.
The genetic context of blaIMP varies among bacterial families from One Health sources.
The study identifies blaIMP-27, blaIMP-64, and blaIMP-95 genes in various bacterial isolates from One Health sources, highlighting their genetic contexts and mobility mechanisms.
Broad spectrum of beta-lactamase coverage and potent antimicrobial activity of xeruborbactam in combination with meropenem against carbapenemase-producing Enterobacterales, including strains resistant to new β-lactam/beta-lactamase inhibitor combinations.
Xeruborbactam in combination with meropenem shows potent activity against carbapenemase-producing Enterobacterales, including strains resistant to other β-lactam/beta-lactamase inhibitor combinations. Specific beta-lactamases like blaIMP-23 and blaSPM-1 were identified as resistant to xeruborbactam.
Broad spectrum of β-lactamase coverage and potent antimicrobial activity of xeruborbactam in combination with meropenem against carbapenemase-producing Enterobacterales, including strains resistant to new β-lactam/β-lactamase inhibitor combinations.
Xeruborbactam in combination with meropenem shows potent activity against carbapenemase-producing Enterobacterales, including strains resistant to other β-lactam/β-lactamase inhibitor combinations. Specific β-lactamases like blaIMP-23 and blaSPM-1 were identified as resistant to xeruborbactam.
Study on Antibacterial Activity of Water Extract of Galla chinensis Against Carbapenemase-Producing Enterobacteriaceae.
The study evaluated the antibacterial activity of Galla chinensis (GC) water extract against carbapenemase-producing Enterobacteriaceae (CPE) and found that it significantly inhibited bacterial growth and reduced the activity of carbapenemase genes.
The hospital sink drain microbiome as a melting pot for AMR transmission to nosocomial pathogens.
The study highlights the hospital sink drain microbiome as a significant reservoir for antimicrobial resistance genes (ARGs), including bla KPC, bla NDM-1, bla OXA-48, and bla IMP-8, which confer resistance to carbapenems. These genes are found in various opportunistic pathogens and are transmitted through horizontal gene transfer, emphasizing the role of sink drains in the spread of multidrug-resistant organisms.
High level of carbapenem resistance and transmission ability of bla(IMP-26) in multidrug-resistant Enterobacter xiangfangensis isolates from China.
The study characterizes the high-level carbapenem resistance mediated by bla(IMP-26) in multidrug-resistant Enterobacter xiangfangensis isolates from China, highlighting its transmission ability and enzymatic activity.
High level of carbapenem resistance and transmission ability of bla(IMP-26) in multidrug-resistant Enterobacter xiangfangensis isolates from China.
The study characterizes the high-level carbapenem resistance mediated by bla(IMP-26) in multidrug-resistant Enterobacter xiangfangensis isolates from China, highlighting its transmission ability and enzymatic activity.
Epidemiological and biological characteristics of IncR plasmids as multihost antibiotic resistance carriers.
The study characterizes various AMR genes carried by IncR plasmids, highlighting their role in the dissemination of resistance to carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, and tetracyclines.
Emergence of drug-resistant Klebsiella pneumoniae phylogroups (K. quasipneumoniae and K. variicola) causing human infections.
The study identified the emergence of drug-resistant Klebsiella pneumoniae phylogroups K. quasipneumoniae and K. variicola, with significant resistance to carbapenems, colistin, and polymyxin B. Key resistance mechanisms included mutations in the PhoP and PhoQ genes and the presence of carbapenemase genes such as bla NDM, bla OXA-48, bla VIM, and bla IMP.
The clinical impact and dissemination of carbapenemase-producing Enterobacter: a genome-based study in China.
The study identifies blaNDM-1, blaNDM-5, blaIMP-4, blaFRI-11, and blaKPC-2 as the primary carbapenemase genes in carbapenemase-producing Enterobacter (CPEn) isolates in China, predominantly found in E. xiangfangensis and E. hoffmannii. These genes confer resistance to carbapenems and are widespread across various Enterobacter species.
Sustainable Joullié-Ugi and Continuous Flow Implementation Led to Novel Captopril-Inspired Broad-Spectrum Metallo-β-Lactamase Inhibitors.
The study reports the development of novel MBL inhibitors inspired by captopril, focusing on improving inhibitory activity against various MBLs while minimizing off-target effects on ACE-1.
Inhibition of metallo-β-lactamases in carbapenem resistant Gram negative bacilli by omeprazole and pantoprazole.
Omeprazole and pantoprazole inhibit metallo-beta-lactamases (MBLs) and reduce meropenem MIC in carbapenem-resistant Gram-negative bacteria. They downregulate MBL genes bla NDM, bla IMP, and bla VIM.
Phenotypic characterisation and prevalence of carbapenem-resistant Enterobacterales in a tertiary care centre in Bihar India.
The study identifies the prevalence of carbapenem-resistant Enterobacterales (CRE) in Bihar, India, highlighting the dominance of Class B carbapenemases (blaNDM, blaOXA-48, blaIMP, blaKPC, blaVIM) and the co-expression of Class A and Class B carbapenemases in E. coli and K. pneumoniae.
Finding the Missing IMP Gene: Overcoming the Imipenemase IMP Gene Drop-Out in Automated Molecular Testing for Carbapenem-Resistant Bacteria Circulating in Latin America.
The study identified the IMP-18 allele as a carbapenemase gene that was not detected by automated qPCR but was confirmed by whole-genome sequencing. A tailored qPCR assay was developed to detect IMP-18 and other alleles, improving the detection of carbapenem-resistant bacteria in Latin America.
Molecular Surveillance of ESBL and Carbapenemase Genes in Gram-Negative Bacterial Pathogens Isolated from Various Clinical Samples Collected from Northern Region of United Arab Emirates.
The study identified the presence of ESBL and carbapenemase genes, including bla CTX-M, bla TEM, bla SHV, bla NDM, and bla IMP, in various Gram-negative bacterial pathogens isolated from clinical samples in the northern region of the UAE. These genes were found to confer resistance to multiple antibiotics, highlighting the need for molecular surveillance to monitor and control the spread of multidrug-resistant bacteria.
Evaluation of the rapid lateral flow assay (LFA) for detection of five major carbapenemase enzyme families in genotypically characterised bacterial isolates.
The study evaluates a rapid lateral flow assay (LFA) for the detection of five major carbapenemase enzyme families (KPC, NDM, VIM, IMP, and OXA-48-like) in genotypically characterized bacterial isolates. The LFA showed high sensitivity and specificity for detecting these carbapenemases, with some limitations noted for NDM detection.
Evaluation of the rapid lateral flow assay (LFA) for detection of five major carbapenemase enzyme families in genotypically characterised bacterial isolates.
The study evaluates a rapid lateral flow assay (LFA) for the detection of five major carbapenemase enzyme families (KPC, NDM, VIM, IMP, and OXA-48-like) in genotypically characterized bacterial isolates. The LFA showed high sensitivity and specificity for detecting these carbapenemases, with some limitations noted for NDM detection.
Rapid detection of carbapenemases in multiresistant Gram-negative strains: evaluation of two tests.
The study evaluated the performance of the NG CARBA-5 test and the Allplex Entero-DR assay for detecting carbapenemases in multidrug-resistant Gram-negative bacteria. Both tests were able to detect various carbapenemase genes, including blaKPC, blaNDM, blaOXA-48, blaVIM, and blaIMP.
High-throughput screening of monoclonal antibodies against carbapenemases using a multiplex protein microarray platform.
The study identifies and characterizes monoclonal antibodies targeting various carbapenemases (bla KPC, bla NDM, bla IMP-1, bla VIM, bla OXA-23, bla OXA-48, bla OXA-58) and the mcr-1 gene, which confers resistance to colistin. These antibodies show high specificity and sensitivity in detecting resistance determinants using a protein microarray platform.
Klebsiella pneumoniae with Two Carbapenemases: Where Molecular Research Stands Now.
The paper discusses the prevalence and genetic environments of various carbapenemases, including KPC-2, NDM-5, IMP-4, NDM-1, and OXA-48, in Klebsiella pneumoniae, highlighting their roles in multidrug resistance and the importance of plasmid-mediated transmission.
Phenotype-genotype discordance in antimicrobial resistance profiles of Gram-negative uropathogens recovered from catheter-associated urinary tract infections in Egypt.
The study identifies several new AMR variants in uropathogens from Egypt, including blaOXA-486, blaOXA-488, blaOXA-905, blaIMP-43, blaPDC-35, blaPDC-45, blaPDC-201 in Pseudomonas aeruginosa, and blaTEM-176, blaTEM-190 in Escherichia coli.
Navigating an evolving microbial landscape: emerging antimicrobial resistance trends and precision stewardship in Tianjin tertiary hospitals (2021-2023).
The study identified significant trends in antimicrobial resistance (AMR) patterns among clinical isolates from hospitals in Tianjin, highlighting the increasing resistance of Klebsiella pneumoniae to various antibiotics, including carbapenems, and the notable decline in ceftazidime/avibactam resistance in E. coli. Additionally, it noted the emergence of resistance in Acinetobacter baumannii and Pseudomonas aeruginosa to several antimicrobials.
Molecular Epidemiology of tet(A)-v1-Positive Carbapenem-Resistant Klebsiella pneumoniae in Pediatric Patients in a Chinese Hospital.
The study identifies the tet(A)-v1 gene as a significant factor in tigecycline resistance among carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates from pediatric patients. It also characterizes various carbapenemase genes, including bla IMP-4, bla NDM-5, bla NDM-1, and bla KPC-2, contributing to carbapenem resistance.
Phenotypic and Molecular Study of Multidrug-Resistant Escherichia coli Isolates Expressing Diverse Resistance and Virulence Genes from Broilers in Tunisia.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from broilers in Tunisia, including bla CTX-M-G1, bla TEM, bla SHV, bla OXA-48, bla IMP, mcr-1, aadA-1, aadA-5, aac(6)-Ib-cr, qnrS, and qnrB.
The carbapenem inoculum effect provides insights into the molecular mechanisms underlying carbapenem resistance in the Enterobacterales.
The study identified that various carbapenemase genes, including blaKPC-3, blaSME-2, blaIMP-4, blaNDM-1, blaVIM-27, blaCMY-10, and blaOXA-48, when expressed in E. coli, significantly increased meropenem MICs and exhibited an inoculum effect. These findings highlight the role of carbapenemases in carbapenem resistance and the importance of the inoculum effect in diagnosing carbapenemase-producing CRE.
In vitro activity of cefiderocol against nosocomial Acinetobacter baumannii.
The study assessed the in vitro activity of cefiderocol against multidrug-resistant Acinetobacter baumannii isolates and found that cefiderocol exhibited high efficacy, with very low resistance rates. However, the presence of various beta-lactamase genes, including bla OXA-23G, bla OXA-24G, bla OXA-48G, bla OXA-58G, bla VEB, bla PER, bla GES, bla KPC, bla NDM, bla VIM, bla IMP, and bla IMI, was associated with resistance to other antibiotics.
Emergence of ST11 Klebsiella pneumoniae co-carrying bla(KPC-2) and bla(IMP-8) on conjugative plasmids.
The study identifies a clinical ST11 Klebsiella pneumoniae strain co-carrying bla(KPC-2) and bla(IMP-8) on conjugative plasmids, highlighting the potential for horizontal gene transfer and multidrug-resistant dissemination.
Recurring acquisition of carbapenemase genes and global emergence of Pseudomonas aeruginosa ST-1047, a lineage shaped by geopolitical conflicts.
The study identifies the recurrence of carbapenemase genes, including blaIMP-1, blaVIM-11, blaNDM-1, and blaDIM-1, in Pseudomonas aeruginosa ST-1047, highlighting their role in the global spread of this lineage, particularly linked to geopolitical conflicts.
Detection of bla(NDM-1) and bla(IMP-1) Metallo-β-Lactamases in Meropenem-Resistant Clinical Escherichia coli Isolates Using Modified Carbapenem Inactivation Method (mCIM) and PCR Techniques.
The study identified bla(NDM-1) and bla(IMP-1) metallo-beta-lactamase genes in meropenem-resistant E. coli isolates, with bla(NDM-1) being more prevalent.
High-risk clonal expansion of IMP-producing Enterobacter cloacae complex in regional Japanese healthcare settings.
The study identifies blaIMP-1 and blaIMP-6 as the primary carbapenemase genes in IMP-producing Enterobacter cloacae complex isolates, along with blaACT-5 and blaACT-7 as beta-lactamase genes. These genes contribute to carbapenem and beta-lactam resistance in the isolates.
High-risk clonal expansion of IMP-producing Enterobacter cloacae complex in regional Japanese healthcare settings.
The study identifies blaIMP-1 and blaIMP-6 as the primary carbapenemase genes in IMP-producing Enterobacter cloacae complex isolates, along with blaACT-5 and blaACT-7 as beta-lactamase genes. These genes contribute to carbapenem and beta-lactam resistance in the isolates.
Nanotechnology Meets superbugs: biocompatible polymeric nanoparticles combat MDR Klebsiella pneumoniae via gene suppression and biofilm Inhibition.
The study shows that imipenem-loaded PCL nanoparticles significantly reduce the expression of carbapenem resistance genes (bla_OXA-48, bla_NDM, and bla_IMP) in CRKP, enhancing the antibacterial efficacy of imipenem.
Multidrug-resistant Pseudomonas aeruginosa: Pathogenesis, resistance mechanisms, and novel therapeutic strategies.
The paper discusses the multidrug resistance mechanisms of Pseudomonas aeruginosa, including beta-lactamases, aminoglycoside modifying enzymes, efflux pumps, and mutations in porin genes. It highlights the role of these mechanisms in antibiotic resistance and the challenges they pose in treating infections.
Revisiting the Metallo-β-Lactamase-Mediated Antibiotic Resistance: Exploring Novel Mechanisms and Therapeutic Strategies.
The paper discusses the role of metallo-beta-lactamases (MβLs) such as NDM, VIM, and IMP in mediating resistance to carbapenems and other β-lactam antibiotics. It highlights the importance of these enzymes in clinical settings and explores potential therapeutic strategies to combat their resistance mechanisms.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
First nationwide survey on Pseudomonas aeruginosa in Bolivia: susceptibility profiles, resistome, and genomic epidemiology.
The study identified multiple carbapenemases, extended-spectrum beta-lactamases, and 16S rRNA methyltransferases in multidrug-resistant Pseudomonas aeruginosa isolates from Bolivia, highlighting the prevalence of high-risk clones and resistance mechanisms.
Virulence and Genomic Profiles of Klebsiella pneumoniae Isolated from Pediatric Patients in Henan, China (2021-2023).
The study identified blaKPC-2 as the predominant carbapenemase in pediatric CRKP isolates, along with blaNDM-1 and blaIMP-4. It also found a high prevalence of hypervirulence-associated genes iuc and rmpA2 in CRKP isolates.
Prevalence of Antibiotic Resistance Determinants in Carbapenem-Resistant Pseudomonas aeruginosa: Focus on Class 1 and 2 Integrons and blaIMP Gene.
The study identified the prevalence of class 1 integrons (intI 1) and the blaIMP gene among carbapenem-resistant Pseudomonas aeruginosa isolates, highlighting their role in multidrug resistance.
Global epidemiological and genetic characteristics of carbapenem-resistant Escherichia coli carrying bla(IMP).
The study characterized nine bla IMP-4-positive carbapenem-resistant Escherichia coli (CREC) strains, identifying bla IMP-4 and qnrS1 as key resistance genes. The strains were multidrug-resistant but susceptible to colistin, tigecycline, and amikacin. High-risk ST1193 and ST973 clones were identified, and IncN plasmids were found to facilitate the horizontal transfer of bla IMP-4.
Global epidemiological and genetic characteristics of carbapenem-resistant Escherichia coli carrying bla(IMP).
The study characterized nine bla IMP-4-positive carbapenem-resistant Escherichia coli (CREC) strains, identifying bla IMP-4 and qnrS1 as key resistance genes. The strains were multidrug-resistant but susceptible to colistin, tigecycline, and amikacin. High-risk ST1193 and ST973 clones were identified, and IncN plasmids were found to facilitate the horizontal transfer of bla IMP-4.
Zinc starvation uncovers bacterial host-specific proteases that shape NDM adaptability in Acinetobacter baumannii.
The study identifies NDM-1 and NDM-5 as metallo-beta-lactamases that confer resistance to carbapenems in Acinetobacter baumannii. It also shows that the stability of NDM-1 is influenced by host-specific proteases CtpA and DegP.
Myco- and microbiological profiling of a human cadaver reveals drug-resistant strains and new fungal records.
The study identified drug-resistant fungal and bacterial isolates from a human cadaver, including new fungal records and species with potential pathogenicity. Antimicrobial susceptibility testing revealed resistance to antifungal agents like voriconazole and amphotericin B, as well as to various antibiotics.
Molecular characterization of a clinical ST145 Klebsiella oxytoca strain co-producing KPC-2 and IMP-96 carbapenemases.
The study identified a clinical ST145 Klebsiella oxytoca strain co-producing KPC-2 and IMP-96 carbapenemases, which exhibit high-level resistance to carbapenems and ceftazidime-avibactam. Both resistance genes are located on conjugative plasmids, facilitating the spread of antimicrobial resistance.
Antimicrobial Resistance Profiles of Pseudomonas aeruginosa in a Korean Community Hospital: In Vitro Activity of Ceftazidime-Avibactam and Other Agents.
The study identified IMP- and KPC-type carbapenemase genes in 14.8% of carbapenem-resistant P. aeruginosa isolates, contributing to resistance against carbapenems.
Plasmid-Mediated Spread of Antibiotic Resistance by Arsenic and Microplastics During Vermicomposting.
Arsenic and microplastics significantly influenced the spread of antibiotic resistance genes (ARGs) during vermicomposting, with specific genes like bla ampC, bla LRA-1, bla FEZ-1, aph(3′)-II, ermB, vanY, mefA, catA, tetX4, bla IMP-11, aadK, ant(3′)-Ih-aac(6′)-Id, ermG, bla OXA-119, tetR, vatE, smeE, mexD, bla OXA-3, amrB, tetY, class A beta-lactamase, dfrA1, alanine adenosyltransferase JOHN-1, mdtB, mdtE, and erm-41 being enriched under various treatment conditions.
Slaughterhouse Wastewater as a Reservoir of Thermotolerant E. coli With Antimicrobial Resistance and Virulence Potential in Dhaka, Bangladesh.
The study identified several AMR genes in E. coli isolates from slaughterhouse wastewater, including blaTEM, blaCTX-M-15, blaIMP-1, blaIMP-4, blaOXA-48, dfrA17, tetA, sul2, and qnrS, highlighting the presence of multidrug-resistant strains.
Slaughterhouse Wastewater as a Reservoir of Thermotolerant E. coli With Antimicrobial Resistance and Virulence Potential in Dhaka, Bangladesh.
The study identified several AMR genes in E. coli isolates from slaughterhouse wastewater, including blaTEM, blaCTX-M-15, blaIMP-1, blaIMP-4, blaOXA-48, dfrA17, tetA, sul2, and qnrS, highlighting the presence of multidrug-resistant strains.
Cross-regional dynamics of antibiotic resistance (AR): Genomic evidence of transmission for Escherichia coli carrying last-resort AR gene between food animals and humans in China.
The study identifies the transmission of LARG-harboring E. coli between food animals and humans in China, highlighting the role of cross-regional transmission in the spread of antibiotic resistance.
The emergence of epidemic, multiple-antibiotic-resistant Stenotrophomonas (Xanthomonas) maltophilia and Burkholderia (Pseudomonas) cepacia.
The paper discusses the emergence of multidrug-resistant Stenotrophomonas (Xanthomonas) maltophilia and Burkholderia (Pseudomonas) cepacia, highlighting their resistance to various antibiotics, including carbapenems, and the challenges in managing infections caused by these organisms.
Molecular events in adipocyte development.
Molecular events in adipocyte development.
Molecular events in adipocyte development.
Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance.
The study identified the blaIMP gene encoding a metallo beta-lactamase (IMP-1) in a clinical isolate of Serratia marcescens, which confers resistance to imipenem and broad-spectrum beta-lactams.
Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance.
Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance.
Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance.
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