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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
LRA5 family class A beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaLRA5 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | uncultured bacterium BLR5 | - | 2009 | EU408358.1 | ACH59002.1 |
| bla_LRA-5 | Reslit | 1 | cephalosporins, penicillin | Escherichia coli | Alaska | 2026 | 8EO5|8EO6|8EO7|8EU7 | - |
Functional metagenomics reveals diverse beta-lactamases in a remote Alaskan soil.
Functional metagenomics reveals diverse beta-lactamases in a remote Alaskan soil.
Proposal of metagenomic-origin LRA-5 as a precursor of active beta-lactamases through Tyr69Gln and Val166Glu amino acid substitutions: a functional and structural analysis.
The study identifies that the wild-type LRA-5 does not confer resistance to β-lactam antibiotics, but the double substitution Tyr69Gln/Val166Glu enables hydrolytic activity against certain β-lactam substrates, indicating an evolutionary pathway for beta-lactamase development.
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