blaMIM

subclass B3 metallo-beta-lactamase MIM-1

Validation StatusConfirmed2+ DBs

Overview

Validation Method: expression and purification in E. coli followed by crystallographic and spectroscopic analysis
Drug Classes: CARBAPENEM, beta lactams
Organisms: Novosphingobium pentaromativorans US6-1, Novosphingobium pentaromativorans, Escherichia coli
Geographic Location: marine
Papers: 1
Databases: Reference Gene CatalogReslit

Papers1

Gene Information

Gene Name: blaMIM
Allele: blaMIM-1
Encodes: subclass B3 metallo-beta-lactamase MIM-1
Source Database: Reference Gene Catalog
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Novosphingobium pentaromativorans US6-1
Sequence Accession: CP009291.1
Protein Accession: AIT78529.1

Structure and mechanism of potent bifunctional β-lactam- and homoserine lactone-degrading enzymes from marine microorganisms.

PMID 32732933 · 2020

The study characterizes two metal-dependent beta-lactamases, MIM-1 and SAM-1, from marine microorganisms, demonstrating their ability to degrade β-lactam antibiotics and homoserine lactones, suggesting a dual functionality in antibiotic resistance and quorum sensing.

Gene Information

Gene Name: blaMIM
Allele: blaMIM-1
Encodes: metal-dependent beta-lactamase
Source Database: Reslit
Confers Resistance To: beta lactams
Organisms Tested In: • Novosphingobium pentaromativorans
• Escherichia coli
Geographic Location: marine
Validation Method: expression and purification in E. coli followed by crystallographic and spectroscopic analysis
Sequence Accession: 6AUF|6MFI|NP_123456|NP_789012

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blaMIM

subclass B3 metallo-beta-lactamase MIM-1

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

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Validation StatusConfirmed2+ DBs

Overview

Validation Method: expression and purification in E. coli followed by crystallographic and spectroscopic analysis
Drug Classes: CARBAPENEM, beta lactams
Organisms: Novosphingobium pentaromativorans US6-1, Novosphingobium pentaromativorans, Escherichia coli
Geographic Location: marine
Papers: 1
Databases: Reference Gene CatalogReslit

Papers1

PMID N/A

Gene Information

Gene Name: blaMIM
Allele: blaMIM-1
Encodes: subclass B3 metallo-beta-lactamase MIM-1
Source Database: Reference Gene Catalog
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Novosphingobium pentaromativorans US6-1
Sequence Accession: CP009291.1
Protein Accession: AIT78529.1

Structure and mechanism of potent bifunctional β-lactam- and homoserine lactone-degrading enzymes from marine microorganisms.

PMID 32732933 · 2020

Gene Information

Gene Name: blaMIM
Allele: blaMIM-1
Encodes: metal-dependent beta-lactamase
Source Database: Reslit
Confers Resistance To: beta lactams
Organisms Tested In: • Novosphingobium pentaromativorans
• Escherichia coli
Geographic Location: marine
Validation Method: expression and purification in E. coli followed by crystallographic and spectroscopic analysis
Sequence Accession: 6AUF|6MFI|NP_123456|NP_789012

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blaMIM

Gene Information

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blaMIM

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