Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Metallo-beta-lactamase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| H121R | - | - | Klebsiella spp | carbapenems | Reslit | Candidate |
| N220A | - | - | E. coli, Klebsiella pneumoniae | carbapenems | Reslit | Candidate |
| Q123A | - | - | E. coli, Klebsiella pneumoniae | carbapenems | Reslit | Candidate |
| D124A | - | - | E. coli, Klebsiella pneumoniae | carbapenems | Reslit | Candidate |
| - | reduced catalytic efficiency and stability | Escherichia coli, Enterobacter cloacae | ampicillin|cefotaxime|ceftazidime|cefoxitin|imipenem|meropenem | Reslit | Candidate |
Antibiotic resistance in Pakistan: a systematic review of past decade.
PHT427 as an effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor restored the susceptibility of meropenem against Enterobacteriaceae producing NDM-1.
Role of Non-Active-Site Residue Trp-93 in the Function and Stability of New Delhi Metallo-β-Lactamase 1.
Trp-93 mutation leads to reduced resistance