blaOXA-24

class D beta-lactamase

Overview

Mechanism: reduces resistance
Drug Classes: imipenem|meropenem, carbapenems
Organisms: Acinetobacter baumannii
Papers: 2
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Y112A	-	reduces resistance	Acinetobacter baumannii	imipenem\|meropenemcarbapenems	Reslit	Candidate
M223A	-	-	Acinetobacter baumannii	carbapenems	Reslit	Candidate

Papers2

Crystal structure of the carbapenemase OXA-24 reveals insights into the mechanism of carbapenem hydrolysis.

PMID 17374723 · 2007

Y112A mutation reduces resistance to imipenem and meropenem

Mutation Information

blaOXA-24: p.Y112A

Protein Change: Y112A
Organisms: Acinetobacter baumannii
Confers Resistance To: imipenem|meropenem
Effect on Function: reduces resistance
Validation Method: mutagenesis and biochemical experiments
Source Database: Reslit

Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase.

PMID 20822105 · 2010

Mutation Information

blaOXA-24: p.Y112A blaOXA-24: p.M223A

Protein Change: Y112A, M223A
Organisms: Acinetobacter baumannii
Confers Resistance To: carbapenems
Validation Method: MIC testing
Source Database: Reslit

blaOXA-24

Mutations

Mutation Information

Mutation Information

Browse AMR Genes

blaOXA-24

Mutations

Mutation Information

Mutation Information