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blaOXA-48

carbapenemase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaOXA-48

Browse AMR rules for blaOXA-48

Overview

Drug Classes: ertapenem|amoxicillin clavulanic acid, carbapenems
Organisms: K. pneumoniae
Papers: 2
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	163 bp upstream of coding DNA sequencedel	-	K. pneumoniae	ertapenem\|amoxicillin clavulanic acid	Reslit	Candidate
V120L	GTT -> TTG	-	-	carbapenems	Reslit	Candidate

Papers2

1

Within-patient evolution of plasmid-mediated antimicrobial resistance.

PMID 36303001 · 2022

mutations in blaOXA-48 gene

Mutation Information

blaOXA-48: c.163 bp upstream of coding DNA sequencedel

Nucleotide Change: 163 bp upstream of coding DNA sequencedel
Organisms: K. pneumoniae
Confers Resistance To: ertapenem|amoxicillin clavulanic acid
Validation Method: phenotypic analysis in JWC*
Source Database: Reslit

2

Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism.

PMID 32963107 · 2020

Clinically observed variant OXA-48 V120L (OXA-519)

Mutation Information

blaOXA-48: p.V120L / c.GTT -> TTG

Protein Change: V120L
Nucleotide Change: GTT -> TTG
Confers Resistance To: carbapenems
Validation Method: kinetic and product studies
Source Database: Reslit