Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
beta-lactamase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| - | inactivates bla OXA-61 gene expression, inhibits transcription resulting in the isolate becoming sensitive to ampicillin | Campylobacter jejuni, Campylobacter coli | ampicillinbeta lactams | Reslit | Candidate |
Isolation and Expression of a Novel Molecular Class D beta-lactamase, OXA-61, from Campylobacter jejuni.
The study identifies and characterizes a novel class D beta-lactamase, OXA-61, from Campylobacter jejuni GC015, which confers resistance to ampicillin, piperacillin, and carbenicillin.
Isolation and expression of a novel molecular class D beta-lactamase, OXA-61, from Campylobacter jejuni.
Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (blaOXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
The study identifies blaOXA-61 as a major determinant of beta-lactam resistance in Campylobacter species, particularly in C. jejuni and C. coli. It also reports a novel beta-lactamase, CjBla2, in some isolates lacking blaOXA-61.
Resistance mechanisms in Campylobacter jejuni.
The paper reviews the resistance mechanisms in Campylobacter jejuni, focusing on fluoroquinolone, macrolide, beta-lactam, tetracycline, and aminoglycoside resistance. Key mechanisms include mutations in gyrA, efflux pumps like CmeABC, modifications of 23S rRNA, and the presence of resistance genes such as aphA-3, TetO, and blaOXA-61.
Prevalence and Antimicrobial Resistance of Campylobacter Isolated from Dressed Beef Carcasses and Raw Milk in Tanzania.
The study identified blaOXA-61, cmeB, tet(O), and aph-3-1 as the primary antimicrobial resistance genes in Campylobacter isolates from raw milk and beef carcasses in Tanzania.
Important Role of a Putative Lytic Transglycosylase Cj0843c in β-Lactam Resistance in Campylobacter jejuni.
Cj0843c, a putative lytic transglycosylase, is required for β-lactam resistance in Campylobacter jejuni. Inactivation of Cj0843c increases susceptibility to various β-lactam antibiotics, and its restoration through complementation restores resistance.
Phylogenetic Diversity and Antimicrobial Resistance of Campylobacter coli from Humans and Animals in Japan.
Antimicrobial Resistance and Virulence-Associated Markers in Campylobacter Strains From Diarrheic and Non-diarrheic Humans in Poland.
The study identified several AMR genes, including blaOXA61, blaOXA184, tet(O), tet(O/32/O), aadE-Cc, and aph(3')-III, which confer resistance to beta-lactams, tetracyclines, and aminoglycosides in Campylobacter isolates. Additionally, mutations in the cmeR gene were linked to increased resistance to erythromycin, fluoroquinolones, and macrolides.
Benchmarking hybrid assembly approaches for genomic analyses of bacterial pathogens using Illumina and Oxford Nanopore sequencing.
The study compared hybrid assembly approaches for bacterial pathogen genomes and identified AMR genes such as blaZ, msr(A), and tet(K) in Staphylococcus aureus.
Characterization of Campylobacter associated gastric enteritis among patients with Human Immunodeficiency Virus (HIV) in a hospital in Accra, Ghana.
The study identified Campylobacter coli isolates resistant to multiple antibiotics, including tetracycline, ciprofloxacin, and erythromycin, with the presence of resistance genes bla OXA-61, cme B, tet (O), and aad E.
Benchmarking Long-Read Assemblers for Genomic Analyses of Bacterial Pathogens Using Oxford Nanopore Sequencing.
The study benchmarks long-read assemblers for genomic analyses of bacterial pathogens using Oxford Nanopore sequencing, highlighting the importance of accurate AMR profiling and identifying specific AMR genes such as aph(3')-III, blaOXA-61, and erm(33).
Whole genome-based characterisation of antimicrobial resistance and genetic diversity in Campylobacter jejuni and Campylobacter coli from ruminants.
The study identified various AMR genes including aminoglycoside-modifying enzymes, tetracycline resistance genes, and beta-lactamases in Campylobacter jejuni and C. coli isolates from ruminants. Mutations in gyrA and rpsL were linked to quinolone and streptomycin resistance, respectively. The presence of specific genetic determinants correlated with phenotypic resistance.
Whole genome-based characterisation of antimicrobial resistance and genetic diversity in Campylobacter jejuni and Campylobacter coli from ruminants.
The study identified various AMR genes including aminoglycoside-modifying enzymes, tetracycline resistance genes, and beta-lactamases in Campylobacter jejuni and C. coli isolates from ruminants. Mutations in gyrA and rpsL were linked to quinolone and streptomycin resistance, respectively. The presence of specific genetic determinants correlated with phenotypic resistance.
Occurrence, Antimicrobial Resistance, and Molecular Characterization of Campylobacter spp. in Intensive Pig Production in South Africa.
The study identified tetracycline resistance gene tetO, ampicillin resistance gene blaOXA-61, and multidrug efflux pump gene cmeB in Campylobacter spp. Additionally, mutations in gyrA (Thr-86-Ile) and 23S rRNA (A2075G and A2074C) were found to confer resistance to quinolones and erythromycin, respectively.
Prevalence and Antimicrobial Resistance Profiles of Foodborne Pathogens Isolated from Dairy Cattle and Poultry Manure Amended Farms in Northeastern Ohio, the United States.
The study identified several antimicrobial resistance genes in foodborne pathogens isolated from dairy cattle and poultry manure amended farms in Northeastern Ohio, including mphA, aadA, aphA1, tetA, aac(3)-IV, sulII, blaTEM, tetB, strA, aac(3)-Iva, ampC, lde, ermB, tet(O), aadB, penA, blaOXA-61, aadE, and aph-3-1.
Genotyping, antibiotic resistance and prevalence of Arcobacter species in milk and dairy products.
The study identifies bla OXA-61 and tet(O) as resistance genes in Arcobacter species isolated from milk, indicating resistance to amoxicillin-clavulanic acid and tetracycline.
Prevalence, Antimicrobial Resistance, and Molecular Characterization of Campylobacter Isolated from Broilers and Broiler Meat Raised without Antibiotics.
The study identified several antimicrobial resistance genes in Campylobacter isolates, including gyrA, tet(O), blaOXA-61, blaOXA-184, and aph(3')-IIIa, which confer resistance to fluoroquinolones, tetracycline, beta-lactamases, and aminoglycosides, respectively.
Withdrawal of antibiotic growth promoters in China and its impact on the foodborne pathogen Campylobacter coli of swine origin.
The study found that the withdrawal of antibiotic growth promoters in China led to an increase in antibiotic resistance in Campylobacter coli, particularly for gentamicin and florfenicol. Several resistance genes, including aadE-Cc, aac(6')-aph(2"), ant(6)-la, aph(3")-lll, aph(2")-lf, tet(O), tet(M), tet(O/32/O), cat, fexA, cfr(C), optrA, blaOXA-193, blaOXA-489, and blaOXA-61, were identified. Mutations in 23S rRNA and gyrA were also associated with resistance to erythromycin and ciprofloxacin, respectively.
Prevalence, antimicrobial resistance, virulence gene profile and molecular typing of Campylobacter species isolated from poultry meat samples.
The study identified several AMR genes, including aadE1, blaOXA-61, tet(O), and cmeB, in Campylobacter jejuni and C. coli isolates from poultry meat samples. These genes conferred resistance to various antibiotics such as erythromycin, ampicillin, ciprofloxacin, chloramphenicol, and tetracycline.
Quantitative detection and genetic characterization of thermotolerant Campylobacter spp. in fresh chicken meats at retail in Japan.
The study identified three antimicrobial resistance genes (gyrA substitution T86I, tetO, and blaOXA-61) in Campylobacter jejuni isolates from fresh chicken meats in Japan.
Relationships between Virulence Genes and Antibiotic Resistance Phenotypes/Genotypes in Campylobacter spp. Isolated from Layer Hens and Eggs in the North of Tunisia: Statistical and Computational Insights.
The study identified several AMR genes and mutations in Campylobacter isolates from layer hens and eggs in Tunisia, including tet(O), cmeB, erm(B), blaOXA-61, and mutations in gyrA and 23S rRNA. These genes and mutations were associated with resistance to tetracycline, fluoroquinolones, macrolides, and beta-lactams.
Broiler house environment and litter management practices impose selective pressures on antimicrobial resistance genes and virulence factors of Campylobacter.
The study identified tetracycline resistance gene tetO in C. coli isolates, beta-lactamase gene blaOXA-61 in C. coli and C. jejuni isolates, and multidrug efflux pumps cmeABC and cmeDEF. These genes were found to differ by species and flock cohort.
Campylobacter spp. isolated from poultry in Iran: Antibiotic resistance profiles, virulence genes, and molecular mechanisms.
The study identified blaOXA-61, tet(O), aadE1, aphA-3-1, and cmeB as key AMR genes in Campylobacter isolates from poultry in Iran, highlighting their role in resistance to beta-lactams, tetracyclines, aminoglycosides, and fluoroquinolones.
Antimicrobial Usage, Susceptibility Profiles, and Resistance Genes in Campylobacter Isolated from Cattle, Chicken, and Water Samples in Kajiado County, Kenya.
The study identified several AMR genes in Campylobacter isolates, including tet(O), blaOXA-61, aph-3-1, gyrA, and cmeB, which confer resistance to tetracycline, ampicillin, gentamicin, ciprofloxacin, and multiple antibiotics. High levels of multidrug resistance were observed, highlighting the urgent need for improved antimicrobial stewardship.
Whole genome characterization of thermophilic Campylobacter species isolated from dairy manure in small specialty crop farms of Northeast Ohio.
The study identified various antimicrobial resistance genes in Campylobacter isolates from dairy manure, including blaOXA-193, aadE-Cc, gyrA_T86I, tetO, aph3'-IIIa, rpsL_K88R, and 50S_L22_A103V, indicating multidrug resistance in these isolates.
Persistence of Campylobacter spp. in Poultry Flocks after Disinfection, Virulence, and Antimicrobial Resistance Traits of Recovered Isolates.
The study identified the presence of AMR genes such as bla OXA-61, cmeB, and tet(O) in Campylobacter isolates, along with mutations in gyrA and 23S rRNA genes that contribute to resistance against various antibiotics.
Development of Meropenem Resistance in a Multidrug-Resistant Campylobacter coli Strain Causing Recurrent Bacteremia in a Hematological Malignancy Patient.
Recurrent Campylobacter jejuni Infections with In Vivo Selection of Resistance to Macrolides and Carbapenems: Molecular Characterization of Resistance Determinants.
The study identifies porA mutations and blaOXA-61 and cmeABC efflux pump modifications as key contributors to carbapenem resistance in Campylobacter jejuni, highlighting the role of structural changes in porin proteins and efflux systems in mediating resistance.
Genomic and Antimicrobial Surveillance of Campylobacter Population in Italian Poultry.
The study identified several AMR genes and mutations in Campylobacter isolates from Italian poultry, highlighting the emergence of multidrug-resistant strains and the prevalence of specific resistance mechanisms such as the T86I mutation in gyrA and the tet(O) gene.
Virulence factors and antimicrobial resistance profiles of Campylobacter isolates recovered from consecutively reused broiler litter.
The study identified tetracycline resistance gene tetO in C. coli isolates, beta-lactamase gene blaOXA-61 in C. coli and C. jejuni isolates, multidrug efflux pumps cmeABC and cmeDEF, and arsenic resistance genes acr3, arsP, and arsB in C. jejuni isolates.
Combined genomic-proteomic approach in the identification of Campylobacter coli amoxicillin-clavulanic acid resistance mechanism in clinical isolates.
The study identified a G57T mutation in the blaOXA61 promoter region associated with increased beta-lactamase expression and ampicillin resistance in Campylobacter coli. A supplemental deletion at position A69 further contributed to amoxicillin-clavulanic acid resistance.
Overview of Ecology and Aspects of Antibiotic Resistance in Campylobacter spp. Isolated from Free-Grazing Chicken Tissues in Rural Households.
The study identified several AMR genes and mutations in Campylobacter spp. isolated from free-grazing chickens, including blaOxA-61, tet(O), tet(A), cmeA, cmeB, cmeC, and a Thr-86-Ile mutation in gyrA, contributing to multidrug resistance.
Antimicrobial resistance patterns and genes of Campylobacter jejuni isolated from chickens in Pasuruan, Indonesia.
The study identified high resistance to enrofloxacin (92.9%) and ciprofloxacin (89.3%) in C. jejuni isolates, with 100% of isolates carrying the gyrA gene, 96.4% carrying blaOXA-61, and 50% carrying tetO.
Arcobacter species isolated from human stool samples, animal products, ready-to-eat salad mixes, and ambient water: prevalence, antimicrobial susceptibility, and virulence gene profiles.
The study identified the presence of antimicrobial resistance genes such as tet(O), blaOXA-61, aphA-3–1, and aadE1 in Arcobacter spp. isolates, highlighting the prevalence of resistance to tetracycline, beta-lactams, and aminoglycosides.
Comparative Genomic Analysis of Livestock-Derived Campylobacter jejuni: Antimicrobial Resistance, Virulence, Mobile Genetic Elements, and Genetic Relatedness.
The study identified blaOXA-61, gyrA(T86I), and tet(O) as the most prevalent antimicrobial resistance genes in Campylobacter jejuni strains from livestock, contributing to resistance against beta-lactams, quinolones, and tetracyclines, respectively.
Phenotypic and whole genome-based characterization of antibiotic resistance of Campylobacter jejuni isolates from chicken livers.
The study identified several AMR genes and mutations in Campylobacter jejuni isolates from chicken livers, including blaOXA-185 and blaOXA-61 for beta-lactam resistance, tet(O) for tetracycline resistance, and CmeABC efflux pump for multidrug resistance. Additionally, a point mutation T86I in the gyrA gene was linked to ciprofloxacin resistance.
Genomic analysis and antimicrobial resistance in human- and poultry-derived Campylobacter jejuni isolates from Hangzhou, China.
The study identified several AMR genes and mutations in Campylobacter jejuni isolates, including gyrA mutations (T86I and T86V) associated with quinolone resistance, tet(O) for tetracycline resistance, and various beta-lactamase genes (blaOXA-61, blaOXA-193, blaOXA-450, blaOXA-451, blaOXA-452, blaOXA-453, blaOXA-489) linked to beta-lactam resistance. Additionally, aminoglycoside resistance genes APH(3')-IIIa and ant(6)-Ia were found in some isolates.
Antimicrobial resistance pattern in Campylobacter strains isolated from both no-antibiotics-ever (NAE) and conventional broiler complexes: Genotypic and phenotypic characterization.
The study identified several AMR genes in Campylobacter strains from NAE and conventional broiler complexes, including bla OXA-61, bla OXA-184, tet (O), tet (O/32/O), and aph (3′)-III. These genes conferred resistance to various antibiotics such as tetracycline, cefoxitin, aztreonam, and gentamicin.
Identification and characterization of an invasive, hyper-aerotolerant Campylobacter jejuni strain causing bacteremia in a pediatric leukemia patient.
The study identifies a novel invasive, hyper-aerotolerant Campylobacter jejuni strain, CNH-HAT-1, which exhibits resistance to penicillins and cephalosporins due to the presence of the beta-lactamase gene blaOXA-61 with a G250A mutation in the major outer-membrane protein PorA.
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