Browse AMR Genes

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blaPEN-B

class A beta-lactamase PEN-B1

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaPEN-B

Browse AMR rules for blaPEN-B

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: cloning in E. coli + nitrocefin hydrolysis
Drug Classes: BETA-LACTAM, meropenem, imipenem, ceftazidime, aztreonam
Organisms: Burkholderia cenocepacia, Burkholderia ubonensis, Escherichia coli
Geographic Location: Puerto Rico|Australia
Alleles: 6
Papers: 3
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants6

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaPEN-B1	Card DatabaseReference Gene Catalog	2	BETA-LACTAM	Burkholderia cenocepacia	-	2009	EU872211.1	ACJ63454.1
blaPEN-B2	Card DatabaseReference Gene Catalog	2	BETA-LACTAM	Burkholderia cenocepacia	-	2009	FJ386399.1	ACO36249.1
blaPEN-B3	Card DatabaseReference Gene Catalog	2	BETA-LACTAM	Burkholderia cenocepacia	-	2009	FJ386401.1	ACO36251.1
blaPEN-B4	Card DatabaseReference Gene Catalog	2	BETA-LACTAM	Burkholderia cenocepacia	-	2009	FJ386402.1	ACO36252.1
blaPenB	Reslit	1	meropenem, imipenem	Burkholderia ubonensis +1	Puerto Rico\|Australia	2020	GCA_002276145.1	-
bla_penB	Reslit	1	ceftazidime, aztreonam +1	Burkholderia cenocepacia	-	2023	-	-

Papers3

1

Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex.

PMID 19075063 · 2009

Gene Information

Gene Name: blaPEN-B
Allele: blaPEN-B1
Encodes: class A beta-lactamase PEN-B1
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Burkholderia cenocepacia
Sequence Accession: EU872211.1
Protein Accession: ACJ63454.1
Notes: ARO:3009023

2

Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex.

PMID 19075063 · 2009

Gene Information

Gene Name: blaPEN-B
Allele: blaPEN-B1
Encodes: class A beta-lactamase PEN-B1, PEN-B beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Burkholderia cenocepacia
Sequence Accession: EU872211.1
Protein Accession: ACJ63454.1
Notes: ARO:3009023

3

Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex.

PMID 19075063 · 2009

Gene Information

Gene Name: blaPEN-B
Allele: blaPEN-B2
Encodes: class A beta-lactamase PEN-B2
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Burkholderia cenocepacia
Sequence Accession: FJ386399.1
Protein Accession: ACO36249.1
Notes: ARO:3009024

4

Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex.

PMID 19075063 · 2009

Gene Information

Gene Name: blaPEN-B
Allele: blaPEN-B2
Encodes: class A beta-lactamase PEN-B2, PEN-B beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Burkholderia cenocepacia
Sequence Accession: FJ386399.1
Protein Accession: ACO36249.1
Notes: ARO:3009024

5

Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex.

PMID 19075063 · 2009

Gene Information

Gene Name: blaPEN-B
Allele: blaPEN-B3
Encodes: class A beta-lactamase PEN-B3
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Burkholderia cenocepacia
Sequence Accession: FJ386401.1
Protein Accession: ACO36251.1
Notes: ARO:3009025

6

Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex.

PMID 19075063 · 2009

Gene Information

Gene Name: blaPEN-B
Allele: blaPEN-B3
Encodes: class A beta-lactamase PEN-B3, PEN-B beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Burkholderia cenocepacia
Sequence Accession: FJ386401.1
Protein Accession: ACO36251.1
Notes: ARO:3009025

7

Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex.

PMID 19075063 · 2009

Gene Information

Gene Name: blaPEN-B
Allele: blaPEN-B4
Encodes: class A beta-lactamase PEN-B4
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Burkholderia cenocepacia
Sequence Accession: FJ386402.1
Protein Accession: ACO36252.1
Notes: ARO:3009026

8

Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex.

PMID 19075063 · 2009

Gene Information

Gene Name: blaPEN-B
Allele: blaPEN-B4
Encodes: class A beta-lactamase PEN-B4, PEN-B beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Burkholderia cenocepacia
Sequence Accession: FJ386402.1
Protein Accession: ACO36252.1
Notes: ARO:3009026

9

Burkholderia ubonensis Meropenem Resistance: Insights into Distinct Properties of Class A beta-lactamases in Burkholderia cepacia Complex and Burkholderia pseudomallei Complex Bacteria.

PMID 32291300 · 2020

The study identifies PenB as the primary beta-lactamase responsible for meropenem and imipenem resistance in Burkholderia ubonensis, demonstrating its role through deletion and complementation experiments.

Gene Information

Gene Name: blaPEN-B
Allele: blaPenB
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: inducible class A beta-lactamase
Confers Resistance To: meropenemimipenem
Organisms Tested In: • Burkholderia ubonensis
• Escherichia coli
Geographic Location: Puerto Rico|Australia
Validation Method: cloning in E. coli + nitrocefin hydrolysis
Sequence Accession: GCA_002276145.1

10

Profiling cell envelope-antibiotic interactions reveals vulnerabilities to β-lactams in a multidrug-resistant bacterium.

PMID 37558695 · 2023

The study identifies bla_penB and K562_RS32470 as beta-lactamase targets of avibactam in Burkholderia cenocepacia, and piuA as a key receptor for cefiderocol uptake.

Gene Information

Gene Name: blaPEN-B
Allele: bla_penB
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: inhibition of ceftazidime/avibactam combination
Confers Resistance To: ceftazidimeaztreonammeropenem
Organisms Tested In: • Burkholderia cenocepacia
Validation Method: CRISPRi knockdown and nitrocefin hydrolysis assay

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