Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
PEN-I family class A beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaPEN-I | Reference Gene Catalog | 1 | BETA-LACTAM | Burkholderia pseudomallei | - | 2003 | AY032873.1 | AAK52327.1 |
| bla_PenI | Reslit | 1 | ampicillin, cephalothin | Escherichia coli +1 | - | 2013 | 3W4Q|3W4P|3W4O | - |
| blaPenI | Reslit | 2 | ceftazidime, cefepime | Burkholderia pseudomallei +1 | - | 2016, 2025 | - | - |
Burkholderia pseudomallei class a beta-lactamase mutations that confer selective resistance against ceftazidime or clavulanic acid inhibition.
Insights into beta-lactamases from Burkholderia Species, Two Phylogenetically Related yet Distinct Resistance Determinants.
The study identifies and characterizes two beta-lactamases, PenA from B. multivorans and PenI from B. pseudomallei, which show distinct resistance profiles against various β-lactam antibiotics.
Exposing a beta-lactamase "Twist": the Mechanistic Basis for the High Level of Ceftazidime Resistance in the C69F Variant of the Burkholderia pseudomallei PenI beta-lactamase.
The C69F variant of the PenI beta-lactamase from Burkholderia pseudomallei confers high-level ceftazidime resistance through a conformational change that enhances catalytic efficiency.
Burkholderia pseudomallei PenI beta-lactamase and variants are potently inhibited by taniborbactam.
Taniborbactam effectively inhibits the beta-lactamase PenI and its variants C69Y and P167S, reducing the MIC of cefepime in E. coli strains expressing these enzymes.
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