Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
β-lactamase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R164W | - | increased resistance to extended-spectrum cephalosporins and β-lactam-β-lactamase inhibitor combinations | Escherichia coli | cefotaxime|amoxicillin clavulanic acid | Reslit | Candidate |
| L169S | - | increased resistance to extended-spectrum cephalosporins | Escherichia coli | cefotaxime | Reslit | Candidate |
| A237T | - | increased resistance to extended-spectrum cephalosporins and β-lactam-β-lactamase inhibitor combinations | Escherichia coli | cefotaxime|amoxicillin clavulanic acid | Reslit | Candidate |
Haemophilus influenzae blaROB-1 Mutations in Hypermutagenic ΔampC Escherichia coli Conferring Resistance to Cefotaxime and β-Lactamase Inhibitors and Increased Susceptibility to Cefaclor.
Mutations in blaROB-1 confer resistance to cefotaxime and amoxicillin-clavulanate, but decrease cefaclor hydrolysis.