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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
class A beta-lactamase SHV-116
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G238S | - | confers extended-spectrum beta-lactamase (ESBL) activity | Klebsiella pneumoniae, Escherichia coli | ceftazidime|cefotaxime|aztreonamcefoxitin|cefotaxime|ceftazidime|ceftriaxone|penicillin|amoxicillin|oxacillin | Reslit | Candidate |
| E240K | - | confers extended-spectrum beta-lactamase (ESBL) activity | Klebsiella pneumoniae, Escherichia coli | ceftazidime|cefotaxime|aztreonamcefoxitin|cefotaxime|ceftazidime|ceftriaxone|penicillin|amoxicillin|oxacillin | Reslit | Candidate |
| L35Q | - | - | Escherichia coli, Klebsiella pneumoniae | cefoxitin|cefotaxime|ceftazidime|ceftriaxone|penicillin|amoxicillin|oxacillin | Reslit | Candidate |
| I8F | - | - | Escherichia coli, Klebsiella pneumoniae | cefoxitin|cefotaxime|ceftazidime|ceftriaxone|penicillin|amoxicillin|oxacillin | Reslit | Candidate |
| R43S | - | - | Escherichia coli, Klebsiella pneumoniae | cefoxitin|cefotaxime|ceftazidime|ceftriaxone|penicillin|amoxicillin|oxacillin | Reslit | Candidate |
| G238A | - | - | Escherichia coli, Klebsiella pneumoniae | cefoxitin|cefotaxime|ceftazidime|ceftriaxone|penicillin|amoxicillin|oxacillin | Reslit | Candidate |
| S164F | - | - | - | cephalosporins | Reslit | Candidate |
| S130G | - | reduces the effectiveness of clavulanic acid | Escherichia coli, Klebsiella pneumonia | beta lactamspenicillin|cephalosporins|aztreonam | Reslit | Candidate |
| - | blaSHV promoter region | Klebsiella pneumoniae | cefiderocol|cephalosporins | Reference Gene Catalog | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaSHV-116 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | ULEP01000017.1 | SYU51410.1 |
| blaSHV-121 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | BETA-LACTAM, UNKNOWN BETA-LACTAM +3 | Klebsiella pneumoniae +1 | UK, Mexico|Mexico City | 2013, 2023 | GQ428198.1 | ACV53157.1 |
| blaSHV-132 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | GU981741.1 | ADU15837.1 |
| blaSHV-146 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | KP868752.1 | AKK23731.1 |
| blaSHV-164 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOTHIN +5 | Klebsiella pneumoniae | Brazil | 2021 | HE981194.1 | CCK86744.1 |
| blaSHV-171 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | FLAQ01000002.1 | SBF43549.1 |
| blaSHV-172 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +5 | Klebsiella pneumoniae | Ghana | 2025 | KF513177.1 | AHA80958.1 |
| blaSHV-173 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | KF513178.1 | AHA80959.1 |
| blaSHV-178 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +1 | Klebsiella pneumoniae +1 | China | 2020 | KF705209.1 | AHA80963.1 |
| blaSHV-179 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | KF705208.1 | AHA80962.1 |
| blaSHV-180 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | KP050487.1 | AJO16040.1 |
| blaSHV-182 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | BETA-LACTAM, UNKNOWN BETA-LACTAM +11 | Klebsiella pneumoniae +2 | China, Beijing, Europe | 2020, 2022, 2023, 2024, 2025 | KP050489.1 | AJO16042.1 |
| blaSHV-183 | Card DatabaseReference Gene CatalogResFinder Database | 4 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Enterobacter cloacae | - | - | HG934764.1 | CDN33427.1 |
| blaSHV-185 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | KM233164.1 | AIS67768.1 |
| blaSHV-186 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +3 | Klebsiella pneumoniae | Djibouti | 2025 | KM233165.1 | AIS67769.1 |
| blaSHV-188 | Card DatabaseReference Gene CatalogResFinder Database | 3 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | LN515534.1 | CEA29751.1 |
| blaSHV-189 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | KP050494.1 | AJO16047.1 |
| blaSHV-190 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | BETA-LACTAM, UNKNOWN BETA-LACTAM +5 | Klebsiella pneumoniae | Chile | 2023 | KP868753.1 | AKK23732.1 |
| blaSHV-191 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | BETA-LACTAM, UNKNOWN BETA-LACTAM +2 | Klebsiella pneumoniae +1 | West Bengal, India | 2025 | KP868754.1 | AKK23733.1 |
| blaSHV-193 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | KR347170.1 | ALI16958.1 |
| blaSHV-195 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | KX619652.1 | ANY40232.1 |
| blaSHV-196 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | KX714286.1 | AOE47041.1 |
| blaSHV-197 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Escherichia coli | - | - | KT946904.1 | APG53535.1 |
| blaSHV-198 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | MF281086.1 | ARX71260.1 |
| blaSHV-199 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | BETA-LACTAM, UNKNOWN BETA-LACTAM +1 | Escherichia coli | Taipei, Taiwan | 2020 | MF373391.1 | ASE05856.1 |
| blaSHV-1b-b | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOTHIN +4 | Klebsiella pneumoniae | - | - | DQ166783.1 | AAZ98828.1 |
| blaSHV-201 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MF804905.1 | ATD84845.1 |
| blaSHV-202 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MF804906.1 | ATD84846.1 |
| blaSHV-204 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | MH243356.1 | AWI33310.1 |
| blaSHV-205 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH814719.1 | AXV45345.1 |
| blaSHV-206 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886581.1 | AYD75378.1 |
| blaSHV-207 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886582.1 | AYD75379.1 |
| blaSHV-208 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886583.1 | AYD75380.1 |
| blaSHV-209 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886584.1 | AYD75381.1 |
| blaSHV-210 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886585.1 | AYD75382.1 |
| blaSHV-211 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886587.1 | AYD75384.1 |
| blaSHV-212 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886588.1 | AYD75385.1 |
| blaSHV-213 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886589.1 | AYD75386.1 |
| blaSHV-214 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886590.1 | AYD75387.1 |
| blaSHV-215 | Card DatabaseReference Gene CatalogReslit | 4 | BETA-LACTAM, penicillin +1 | Klebsiella pneumoniae +1 | West Bengal, India | 2025 | MH886591.1 | AYD75388.1 |
| blaSHV-216 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886592.1 | AYD75389.1 |
| blaSHV-217 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886593.1 | AYD75390.1 |
| blaSHV-218 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886594.1 | AYD75391.1 |
| blaSHV-219 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886595.1 | AYD75392.1 |
| blaSHV-220 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886596.1 | AYD75393.1 |
| blaSHV-221 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886597.1 | AYD75394.1 |
| blaSHV-222 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886598.1 | AYD75395.1 |
| blaSHV-223 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886599.1 | AYD75396.1 |
| blaSHV-224 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886600.1 | AYD75397.1 |
| blaSHV-225 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886601.1 | AYD75398.1 |
| blaSHV-226 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886602.1 | AYD75399.1 |
| blaSHV-227 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MH886603.1 | AYD75400.1 |
| blaSHV-228 | Card DatabaseReference Gene CatalogReslit | 4 | BETA-LACTAM, ceftazidime +3 | Klebsiella pneumoniae +2 | Andaman and Nicobar Islands | 2022 | MH886604.1 | AYD75401.1 |
| blaSHV-229 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | - | MZ748304.1 | QYZ89891.1 |
| blaSHV-236 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | - | OR863408.1 | WPM90268.1 |
| blaSHV-239 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | - | OR876331.1 | WPR17817.1 |
| blaSHV-240 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | - | OR876332.1 | WPR17818.1 |
| blaSHV-241 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | - | OR876333.1 | WPR17819.1 |
| blaSHV-242 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | - | OR876334.1 | WPR17820.1 |
| blaSHV-243 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | - | OR876335.1 | WPR17821.1 |
| blaSHV-244 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | - | PP532823.1 | WXU52833.1 |
| blaSHV-245 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | - | PP847210.1 | XBP46884.1 |
| blaSHV-246 | Reference Gene Catalog | 1 | BETA-LACTAM | Serratia marcescens | - | - | PV075178.1 | XOU30642.1 |
| blaSHV-247 | Reference Gene Catalog | 1 | BETA-LACTAM | Providencia stuartii | - | - | PV075179.1 | XOU30643.1 |
| blaSHV-248 | Reference Gene Catalog | 1 | BETA-LACTAM | Klebsiella pneumoniae | - | - | PV075180.1 | XOU30644.1 |
| blaSHV-249 | Reference Gene CatalogReslit | 2 | BETA-LACTAM, penicillin +1 | Klebsiella pneumoniae +1 | West Bengal, India | 2025 | PV075181.1 | XOU30645.1 |
| blaSHV-250 | Reference Gene Catalog | 1 | BETA-LACTAM | Klebsiella pneumoniae | - | - | PV075182.1 | XOU30646.1 |
| blaSHV-251 | Reference Gene Catalog | 1 | BETA-LACTAM | Klebsiella pneumoniae | - | - | PV075183.1 | XOU30647.1 |
| blaSHV-252 | Reference Gene Catalog | 1 | BETA-LACTAM | Klebsiella pneumoniae | - | - | PV075184.1 | XOU30648.1 |
| blaSHV-253 | Reference Gene Catalog | 1 | BETA-LACTAM | Klebsiella pneumoniae | - | - | JBJLTU020000001.1 | MFV5158421.1 |
| blaSHV-254 | Reference Gene Catalog | 1 | BETA-LACTAM | Klebsiella pneumoniae | - | - | JBJLSZ020000001.1 | MFV5108851.1 |
| blaSHV-255 | Reference Gene Catalog | 1 | BETA-LACTAM | Klebsiella pneumoniae | - | - | PV712801.1 | XUZ93911.1 |
| blaSHV-256 | Reference Gene Catalog | 1 | BETA-LACTAM | Klebsiella pneumoniae | - | - | PX649182.1 | YCB24295.1 |
| blaSHV-37 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +1 | Klebsiella pneumoniae | Malawi | 2019 | AF467948.1 | AAL82593.1 |
| blaSHV-50 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | AY288915.1 | AAP41108.1 |
| blaSHV-63 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | EU342351.1 | ABY56290.1 |
| blaSHV-93 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +2 | Klebsiella pneumoniae | China | 2019 | EF373969.1 | ABN49110.1 |
| blaSHV-94 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | EF373970.1 | ABN49111.1 |
| blaSHV-96 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Acinetobacter baumannii | - | - | EF373971.1 | ABN49112.1 |
| blaSHV-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 79 | TICARCILLIN, CEPHALOTHIN +25 | Klebsiella pneumoniae +21 | Korea, France, Taiwan, Italy, Burkina Faso, Germany, USA|Greece|Sweden|Colombia|Brazil|Israel, Scandinavia|Norway|Sweden|Denmark, Global, Europe, UK, India, Iran, China, Saudi Arabia, Caribbean, Guangzhou, China|Guangzhou, Thailand, India|United States, United States, Malawi, Cambodia, Nepal, Germany|Lower Saxony|North-Rhine-Westphalia, South Korea, Brazil, Pakistan, Romania, Madagascar, United States|France|Italy|Switzerland|Greece|China|Germany|Spain|Japan|UK|Canada|Australia, Bulgaria, Europe|Asia|North America|Western and South-Eastern Asia, Norway, Mexico|Mexico City, Oman, International Space Station, Slovak Republic, Australia, Malaysia, Nigeria, Southern China, Bangladesh, Ghana, New York City | 1999, 2000, 2001, 2002, 2003, 2004, 2007, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | FJ668814.1 | ACR66323.1 |
| blaSHV-106 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 14 | AZTREONAM, TICARCILLIN +19 | Klebsiella pneumoniae +1 | Europe, China, Europe|Asia|North America|Western and South-Eastern Asia, Egypt, Ghana | 2009, 2015, 2021, 2022, 2023, 2025 | AM941847.1 | CAQ03506.1 |
| blaSHV-107 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, AMOXICILLIN +8 | Klebsiella pneumoniae +1 | Portugal | 2009, 2012 | AM941848.1 | CAQ03507.1 |
| blaSHV-108 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | BETA-LACTAM, UNKNOWN BETA-LACTAM +8 | Klebsiella pneumoniae | Iran, Madagascar | 2000, 2011, 2016, 2022 | HM751100.1 | ADR80606.1 |
| blaSHV-112 | Card DatabaseReslit | 2 | penicillin, cephalosporins | Klebsiella pneumoniae +1 | Nigeria | 2015 | EU477409.1 | ACC99191.1 |
| blaSHV-115 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | 2016 | NG_067162.1 | WP_156404661.1 |
| blaSHV-122 | Card Database | 1 | - | Klebsiella pneumoniae | - | - | HM751103.1 | ADR80609.1 |
| blaSHV-123 | Card Database | 1 | - | Klebsiella pneumoniae | - | - | GQ390805.1 | ACV32633.1 |
| blaSHV-124 | Card Database | 1 | - | Klebsiella pneumoniae | - | - | GQ390806.1 | ACV32634.1 |
| blaSHV-125 | Card Database | 1 | - | Klebsiella pneumoniae | - | - | GQ390807.1 | ACV32635.1 |
| blaSHV-126 | Card Database | 1 | - | Escherichia coli | - | - | GQ390808.1 | ACV32636.1 |
| blaSHV-127 | Card Database | 1 | - | Klebsiella pneumoniae | - | - | GQ390809.1 | ACV32637.1 |
| blaSHV-140 | Card Database | 1 | - | Klebsiella pneumoniae | - | - | JN051143.1 | AEK80394.1 |
| blaSHV-167 | Card Database | 1 | - | Klebsiella pneumoniae | - | - | AB733453.1 | BAM28879.1 |
| blaSHV-194 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2016 | NG_051169.1 | WP_065419573.1 |
| blaSHV-20 | Card DatabaseReslit | 2 | ceftazidime, cefotaxime | Klebsiella pneumoniae | South Africa | 2001 | AF117744.1 | AAF34334.1 |
| blaSHV-200 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | ampicillin, penicillin +6 | Klebsiella pneumoniae | Gothenburg, United States | 2018, 2020 | NG_055588.1 | WP_096807447.1 |
| blaSHV-203 | Card DatabaseReference Gene CatalogResFinder Database | 5 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Klebsiella pneumoniae | - | 2020 | NG_055668.1 | WP_099156054.1 |
| blaSHV-21 | Card DatabaseReslit | 2 | ceftazidime, cefotaxime | Klebsiella pneumoniae | South Africa | 2001 | AF117745.1 | AAF34335.1 |
| blaSHV-22 | Card DatabaseReslit | 2 | ceftazidime, cefotaxime | Klebsiella pneumoniae | South Africa | 2001 | AF117746.1 | AAF34336.1 |
| blaSHV-23 | Card Database | 1 | - | Klebsiella pneumoniae | - | - | AF117747.1 | AAF34337.1 |
| blaSHV-28 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 35 | BETA-LACTAM, UNKNOWN BETA-LACTAM +21 | Klebsiella pneumoniae +6 | Israel, UK, West Africa|Conakry, Guinea, Malawi, Cambodia, China, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, South Korea, Portugal, Northern Portugal, Europe|Spain, Sudan, Saudi Arabia, Philadelphia metropolitan region, Southeast Nigeria, Northern China, Edo state, Nigeria, Canada|Cambodia|India|Vietnam|USA|China, Malaysia, Armenia, Europe|Africa|North America|South America|Asia|Oceania, Europe, Nigeria, Sub-Saharan Africa, Bangladesh | 2009, 2013, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AF299299.1 | AAG15384.1 |
| blaSHV-2A | Card Database | 1 | - | Klebsiella pneumoniae | - | - | X98102.1 | CAA66730.1 |
| blaSHV-33 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | ampicillin, cephalothin +10 | Klebsiella pneumoniae | UK, California|Europe|North America|Republic of Congo, Northern China | 2001, 2013, 2021, 2022 | JX268631.1 | AFN82060.1 |
| blaSHV-39 | Card DatabaseReslit | 2 | cephalosporins, penicillin | Klebsiella pneumoniae | United Kingdom|Ireland | 2017 | AY150585.1 | AAN77730.1 |
| blaSHV-53 | Card Database | 1 | - | Klebsiella pneumoniae | - | - | AY590467.1 | AAT01223.1 |
| blaSHV-55 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | AZTREONAM, TICARCILLIN +12 | Klebsiella pneumoniae | Portugal | 2006, 2022 | AJ863560.2 | CAI10727.2 |
| blaSHV-60 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, CEPHALOTHIN +5 | Klebsiella pneumoniae | UK | 2008, 2009, 2013 | AB302939.1 | BAF92780.1 |
| blaSHV-83 | Card Database | 1 | - | Klebsiella pneumoniae | - | - | AM176558.2 | CAJ47138.2 |
| blaSHV-2a | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 27 | ceftazidime, cefotaxime +24 | Pseudomonas aeruginosa +9 | France, Korea, Spain, Australia, South Korea|Korea, Tunisia, Turkey, Canada, Slovakia, Italy, Central African Republic, Egypt, Dominican Republic|India|Thailand|Vietnam, Mexico, Democratic Republic of the Congo, China, Thailand|South Korea, Germany, Iraq, Oregon, USA|Oregon | 1991, 1997, 1999, 2000, 2002, 2003, 2004, 2005, 2006, 2007, 2013, 2015, 2019, 2020, 2021, 2023, 2024 | AF074950 | CAA66730.1 |
| blaSHV-5 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 39 | ceftazidime, cefotaxime +24 | Escherichia coli +12 | Taiwan, Connecticut, Korea, Spain, Greece, The Netherlands, Mexico, Canada, Poland, Honduras, Italy, Brazil, Eastern Europe|India|Latin America|Asia Pacific|North America|Western Europe, United States, Germany, China, Arabian Peninsula|Saudi Arabia|United Arab Emirates|Kuwait|Oman|Qatar|Bahrain, Egypt, Western Pennsylvania, global, Netherlands, South Africa, France, Warsaw, Poland | 1990, 1998, 1999, 2000, 2001, 2002, 2003, 2004, 2006, 2008, 2009, 2010, 2012, 2013, 2014, 2015, 2017, 2018, 2019, 2020, 2021, 2023, 2024 | AF006225|AF006226|AF006227|AF006228 | CAA39164.1 |
| blaSHV-8 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | ceftazidime, cefotaxime +14 | Escherichia coli +1 | Connecticut, Italy | 1997, 1999, 2006 | PMC163766 | AAB51384.1 |
| blaSHV-4 | Card DatabaseReference Gene CatalogReslit | 12 | ceftazidime, cefotaxime +10 | Klebsiella pneumoniae +3 | Connecticut, Korea, France, Brazil, Europe, Ghana, Egypt | 1990, 1999, 2000, 2001, 2003, 2004, 2005, 2019, 2020, 2024 | AF032125|AF032126 | SPD96731.1 |
| blaSHV-2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 45 | AZTREONAM, TICARCILLIN +23 | Escherichia coli +10 | Korea, Taiwan, Spain, Vietnam, Canada, Poland, United States, China, Japan, Austria, Dominican Republic|India|Thailand|Vietnam, Mexico, Germany, South Korea, Norway, global, Netherlands, Cambodia, Germany|Lower Saxony|North-Rhine-Westphalia, Italy, France, Europe|Asia|North America|Western and South-Eastern Asia, Tunisia, Canada|Cambodia|India|Vietnam|USA|China, Tennessee, USA|East Tennessee, Bangladesh|Brazil|Greece|Italy|Kenya|South Africa|Thailand|Uganda|Vietnam, Kentucky|USA, Europe, West Bengal, India, South Africa | 1998, 1999, 2000, 2001, 2002, 2004, 2005, 2008, 2009, 2010, 2011, 2012, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AF148851.1 | AAD37413.1 |
| blaSHV-15 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Escherichia coli | - | 2000 | AJ011428.2 | CAB37325.2 |
| blaSHV-13 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | AZTREONAM, TICARCILLIN +16 | Klebsiella pneumoniae +2 | Madagascar, Nigeria | 2000, 2023, 2024 | AF164577.1 | AAD43815.1 |
| blaSHV-12 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 229 | ceftazidime, cefotaxime +34 | Klebsiella pneumoniae +59 | Taiwan, Korea, China, Australia, South Korea, Canada, France|Mali, Tel Aviv, Israel, Cameroon, Italy, Central African Republic, United States, Poland, Eastern Europe|India|Latin America|Asia Pacific|North America|Western Europe, Israel, Morocco, Germany, Nigeria, Paris, France, Japan, Belgium, Greece|Spain|Taiwan|Turkey|Colombia|Puerto Rico|USA|Argentina|Chile|Germany|Italy|Philippines|Thailand, Switzerland, South China, Europe|Asia|North America|South America, Europe, New York City|Vietnam|Panama|Egypt|India|Uganda|Uruguay, Netherlands, Madagascar, Arabian Peninsula|Saudi Arabia|United Arab Emirates|Kuwait|Oman|Qatar|Bahrain, Egypt, United Kingdom, Greece, Western Pennsylvania, Ankara, Turkey, Austria, Spain, Dominican Republic|India|Thailand|Vietnam, Nepal, United States|Guatemala|India|Jordan|Lebanon|France|Poland|Romania|Russia, Iran, United Kingdom|Ireland, Tanzania, Dublin, Oltrepò Pavese Area, Northern Italy|Italy, Shanghai, China, Pakistan, global, Northwest China, India, France, Malawi, Vietnam, Cambodia, France|Spain, Denmark, Norway, Texas, USA, Sweden, China|USA|Italy|Israel, Europe|EU/EEA|China|Spain|USA|Denmark|Sweden|Belgium|Switzerland|Norway|Netherlands|Slovakia|Germany|Romania|Italy|Cyprus, Europe|Italy, Northwest Spain, Uruguay, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, Mexico, Thailand|South Korea, Europe|Spain|Hungary|Germany|France|Belgium|Poland|United Kingdom|Denmark, Europe|Poland, Europe|Germany, India|Pakistan|Bangladesh|Philippines|Democratic Republic of the Congo, Northeast China, Cleveland Clinic, OH, Europe|broiler production pyramid, Northern Portugal, New Zealand, Finland|Eastern Finland, Kuwait, Boston, MA|Orange, CA, Saudi Arabia, Basque Country, northern Spain|Basque Country, Tunisia, Peru, Romania, Portugal, Europe|North America, Northern China, Europe|Switzerland|Croatia|Hungary|Poland|Slovenia, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Ireland, Europe|Asia|North America|Western and South-Eastern Asia, Blantyre, Malawi, Madrid|Spain, Houston, Texas|Houston, TX, Mexico|Mexico City, Canada|Cambodia|India|Vietnam|USA|China, Global, Germany|Australia|Taiwan|USA|Canada|Denmark, Pittsburgh, USA|China|India|Thailand|Brazil|Hungary|South Africa|Egypt|Tunisia|Europe|Asia, Europe|Italy|Brazil|Czechia|Germany|Finland|Netherlands|Norway|Sweden, Bangladesh|Brazil|Greece|Italy|Kenya|South Africa|Thailand|Uganda|Vietnam, China|North America|Asia|Europe|Oceania|South America|Africa|Global|West China, Bulgaria|Europe, Beijing, Rwanda, France|Germany|Netherlands|Norway|Spain|United Kingdom|Europe, Gabon, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, Europe|Africa|North America|South America|Asia|Oceania, Sub-Saharan Africa, Guadeloupe, Kathmandu, Nepal|Nepal, Normandy|France, United Arab Emirates | 1997, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AF167990 | AHN60527.1 |
| blaSHV-24 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, AZTREONAM +9 | Escherichia coli | Japan | 2000 | AB023477 | BAA84973.1 |
| blaSHV-3 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | cefoxitin, cefotaxime +16 | Escherichia coli +2 | Korea, global, Ghana | 1989, 2000, 2018, 2019 | PMC172828 | ANA06389.1 |
| blaSHV-18 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | ceftazidime, cefotaxime +14 | Klebsiella pneumoniae K6 +4 | China, Europe | 2000, 2014, 2023, 2024, 2025 | AF132290 | AAF64386.1 |
| blaSHV-19 | Card DatabaseReference Gene CatalogReslit | 3 | ceftazidime, cefotaxime +1 | Klebsiella pneumoniae | South Africa | 2001 | AF045475|AF117743|AF117744|AF117745|AF117746 | HBU8935839.1 |
| blaSHV-14 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | ceftazidime, cefotaxime +10 | Klebsiella pneumoniae +3 | Netherlands | 2001, 2015, 2023 | AF226622 | AAG17550.1 |
| blaSHV-29 | Card DatabaseReference Gene CatalogResFinder Database | 4 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Klebsiella pneumoniae | - | 2001 | AF301532.1 | AAG49894.1 |
| blaSHV-27 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 22 | AZTREONAM, TICARCILLIN +20 | Klebsiella pneumoniae +5 | UK, Japan, Netherlands, Malawi, UK|United Kingdom, Germany|Lower Saxony|North-Rhine-Westphalia, Europe, Northern Portugal, South Africa, Madagascar, Northern China, Andaman and Nicobar Islands, United States, Oman, Australia, West Bengal, India | 2001, 2013, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AF293345.1 | AAG01039.1 |
| blaSHV | Reslit | 454 | cephalosporins, ceftazidime +23 | Escherichia coli +189 | United States|Taiwan|Australia|South Africa|Turkey|Belgium|Argentina, United States, Spain, Australia, Taiwan, China, Canada, Texas, Thailand, Italy, Malaysia, India, Ireland, France, Iran, Iraq, Brazil, Germany, Turkey, Manaus, State of Amazonas, Brazil, Lake Taihu, Alaska|USA, Nepal, Argentina, Southern Taiwan, Poland, Michigan|California, Chengdu, China, Romania, Mexico, Hong Kong, Benin, Zambia, Ecuador, Greece, Egypt, Southwestern Nigeria, Mali, Guadeloupe, Netherlands, Kenya, Europe, Andhra Pradesh, India, Al-Najaf Province, Iraq, Philadelphia, Pennsylvania, Alberta, Japan, Sri Lanka, South India, Qatar, Northwest China, Heilongjiang Province, China, Pakistan, South Africa, central Negev Desert, Israel, Mexico City, Lebanon, Malawi, Saudi Arabia, Chile, Al-Najaf City, Iraq, Jordan, East Java, Indonesia, Shenzhen, southern China, Nigeria, Northern Thailand, Henan, China, north-central Iran, Enugu, Nigeria, North-West Province, South Africa, Port-Harcourt, Nigeria, Brazilian Amazon|Brazil, Portugal|Spain|France, UK, Bangladesh, mid-Adriatic coast, UK|United Kingdom, Ethiopia, Emilia Romagna|Italy, Dominican Republic, Eastern Cape Province, South Africa, Taiwan|Taipei, Taiwan, southeastern China, Thailand|South Korea, Eastern Cape Province, South Korea, South Asia|Southeast Asia|India|Thailand|Cambodia|Vietnam|Egypt|Jordan|China, Sweden, Burkina Faso, Morocco, Shanghai, China, Tunisia, Colombia, Southern Thailand|Thailand, Kelantan|Terengganu, Nicaragua, Western Algeria, Philippines, Europe|United Kingdom, North Jordan, Ghana, Romania|France, Upper Gulf of Thailand|Thailand|Ireland, Kiambu County, Kenya, Accra, Ghana, Eastern Cape province, South Africa|South Africa, Shandong Province, China, North Sea|Baltic Sea, Kurdistan–Iraq, West Bengal, India, South West Nigeria, Southwest Nigeria, Slovakia, India|Thailand|Vietnam|Myanmar|Denmark|Germany|Algeria|Portugal|Spain|Brazil|United States, Ontario, Canada, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Gaza strip, Nghe An province, Vietnam, Czech Republic, Uganda, Boeotia regional district, Greece, Van province, Turkey, Vietnam, Algeria, Eastern Cape Province, South Africa|Eastern Cape, Shanxi Province|Shanxi Province, China, Gaza Strip, Ogun state, East Tennessee, Northwestern Nigeria, South-Eastern Bangladesh|Bangladesh, Türkiye, Portugal, Southeast Nigeria, Istanbul, Türkiye|Istanbul, Turkey, Croatia, Southern Thailand, North Sinai|South Sinai, Egypt, Europe|Poland, Palestine, Iran|India|Bangladesh|China|Nepal|Ethiopia|Russia|Pakistan|Egypt|Brazil, northern India, Bulgaria, Europe|Greece, Central Italy, Senegal, Khartoum, Sudan|Egypt, USA|China|Japan|Spain|United Kingdom|Germany|France|South Korea|Netherlands|Viet Nam|Laos|Canada|Czech Republic|Argentina|Brazil|Belgium|Denmark|Iran|Australia|Croatia|Ghana|Mexico|Missing, Gulf Cooperation Council countries|Gulf Cooperation Council|Gulf Cooperation Council region, Central Macedonia|Epirus|Greece, mid-Atlantic United States, Calabria|Italy, Indonesia, Peru, Scotland|England, Surabaya, Aligarh City, Western Nepal, Southern India|India, Ashanti Region, Ghana, Kisii, Kenya|Kenya, Shandong Province, South Lebanon, Southwest China, Bangkok, Thailand, Cameroon, Europe|Iraq, India|Delhi NCR, China|Thailand|USA|Spain|Norway|Japan|Vietnam|Hong Kong, Central China, Hungary | 2000, 2001, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | X91840 | - |
| blaSHV-11 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 76 | ampicillin, cephalothin +28 | Klebsiella pneumoniae +10 | Taiwan, France, Italy, USA|Greece|Sweden|Colombia|Brazil|Israel, UK, United States, Nigeria, Romania, Austria|Germany, Iran, South Korea, China, Malawi, Poland, Cambodia, Brazil, Thailand, Gabon, Madagascar|Cambodia|Senegal, Europe, California|Europe|North America|Republic of Congo, Brasília, Brazil, Eastern China, Cleveland Clinic, OH, Northern Portugal, Spain, Kuwait, Germany, Southern Bangladesh, South America|Australia|France|Vietnam|China, Bulgaria, Northern China, Shandong Province, China, Andaman and Nicobar Islands, Europe|Asia|North America|Western and South-Eastern Asia, Gambia, Mexico|Mexico City, Oman, Brazilian Amazon Region, Ghana, India, Malaysia, Bangladesh, Pakistan, Armenia, Northern Nigeria|Nigeria, Europe|Asia|North America | 1997, 2001, 2004, 2006, 2010, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AF208796|AF227204 | CAA66729.1 |
| blaSHV-25 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | ampicillin, TICARCILLIN +6 | Klebsiella pneumoniae | Taiwan, Malawi | 2001, 2019 | AF208796|AF227204 | AAF37209.2 |
| blaSHV-26 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | ampicillin, cephalothin +16 | Klebsiella pneumoniae +2 | Taiwan, Malawi, Nigeria, Europe | 2001, 2015, 2019, 2024, 2025 | AF208796|AF227204 | AAF36719.1 |
| blaSHV-16 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, AZTREONAM +9 | Klebsiella pneumoniae +1 | - | 2001 | AF072684 | AAC98092.2 |
| blaSHV-32 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ampicillin, cephalothin +8 | Klebsiella pneumoniae | - | 2001 | AY037778|AY037779|AY037780 | AAK69828.1 |
| blaSHV-38 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | imipenem, ceftazidime +17 | Klebsiella pneumoniae +1 | China|Shanghai, China, Ghana | 2003, 2022, 2025 | AY079099 | AAL79576.1 |
| blaSHV-43 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | cefotaxime, ceftazidime +6 | Klebsiella pneumoniae | China | 2003 | AY065991 | AAL40899.1 |
| blaSHV-44 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOTHIN +4 | Klebsiella pneumoniae | - | 2003 | AY259119.1 | AAP82228.1 |
| blaSHV-34 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Escherichia coli | - | 2003 | AY036620.1 | AAK64187.1 |
| blaSHV-46 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Klebsiella oxytoca | - | 2003 | AY210887.1 | AAO53445.1 |
| blaSHV-30 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | cefotaxime, ceftazidime +14 | Escherichia coli +4 | Canada, United States, New Hampshire, USA|global | 2004, 2005, 2007, 2015, 2023 | AF535127|AF535128|AF535129|AF535130|AY243512 | AAT75225.1 |
| blaSHV-40 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | cefotaxime, AZTREONAM +16 | Klebsiella pneumoniae | Canada, United Kingdom|Ireland, Egypt, Tennessee, USA|East Tennessee | 2004, 2017, 2021, 2023 | AF535127|AF535128|AF535129|AF535130|AY243512 | AAN04882.1 |
| blaSHV-41 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | cefotaxime, AZTREONAM +14 | Klebsiella pneumoniae | Canada, Ghana | 2004, 2025 | AF535127|AF535128|AF535129|AF535130|AY243512 | AAN04883.1 |
| blaSHV-42 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | cefotaxime, AZTREONAM +10 | Klebsiella pneumoniae | Canada, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China | 2004, 2024 | AF535127|AF535128|AF535129|AF535130|AY243512 | AAN04884.1 |
| blaSHV-35 | Card DatabaseReference Gene CatalogResFinder Database | 4 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Klebsiella pneumoniae | - | 2004 | AY070258.1 | AAL68926.1 |
| blaSHV-49 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | ampicillin, amoxicillin +12 | Klebsiella pneumoniae +1 | France, Poland | 2004, 2008 | AY528717|AY528718 | AAS98184.1 |
| blaSHV-57 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | ceftazidime, AZTREONAM +11 | Escherichia coli | Taiwan, China | 2005, 2012 | AY223863 | AAO66446.1 |
| blaSHV-5a | Reslit | 1 | ceftazidime, cefotaxime | Klebsiella pneumoniae +1 | Lebanon | 2005 | - | - |
| blaSHV-7 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 10 | ceftazidime, aztreonam +17 | Enterobacter cloacae +2 | Malawi, United States, Pittsburgh | 1995, 2005, 2015, 2019, 2023 | AY661885 | AAA87176.1 |
| blaSHV-70 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | AZTREONAM, TICARCILLIN +9 | Enterobacter cloacae +1 | Nigeria | 2006, 2024 | DQ013287.1 | AAY42633.1 |
| blaSHV-31 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | cephalosporins, AZTREONAM +16 | Klebsiella pneumoniae +1 | The Netherlands, Taiwan, Egypt, Sub-Saharan Africa | 2007, 2015, 2017, 2025 | AY277255 | AAP33454.2 |
| blaSHV-64 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | AZTREONAM, TICARCILLIN +11 | Klebsiella pneumoniae +3 | Europe|EU|non-EU|non-Member State|China|Spain|USA|Finland|Germany|Norway|Switzerland|Netherlands, Europe | 2006, 2019, 2020 | DQ174304.1 | ABA06586.1 |
| blaSHV-65 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN +3 | Klebsiella pneumoniae | Netherlands | 2006, 2015 | DQ174305.1 | ABA06587.1 |
| blaSHV-66 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | AZTREONAM, TICARCILLIN +9 | Klebsiella pneumoniae +1 | Europe|Denmark|France|Germany|United Kingdom | 2006, 2021 | DQ174306.1 | ABA06588.1 |
| blaSHV-67 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2006 | DQ174307.1 | ABA06589.1 |
| blaSHV-69 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2006 | DQ174308.1 | ABA06590.1 |
| blaSHV-36 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | ceftazidime, cefotaxime +7 | Escherichia coli +2 | Japan, Malawi, United States, UK | 2007, 2019, 2020 | AB300358 | AAL82592.1 |
| blaSHV-101 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +6 | Klebsiella pneumoniae | Madagascar | 2007, 2022 | EU155018.1 | ABV72593.1 |
| blaSHV-92 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2008 | DQ836922.1 | ABH04327.1 |
| blaSHV-72 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, AMOXICILLIN +7 | Klebsiella pneumoniae | - | 2008 | AM176547.2 | CAJ47127.2 |
| blaSHV-85 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOTHIN +4 | Klebsiella pneumoniae | - | 2008 | DQ322460.1 | ABC54571.1 |
| blaSHV-102 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | AZTREONAM, TICARCILLIN +9 | Escherichia coli | Europe | 2008, 2025 | EU024485.1 | ABS72342.1 |
| blaSHV-89 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOTHIN +4 | Klebsiella pneumoniae | - | 2009 | DQ193536.1 | ABA60809.1 |
| blaSHV-103 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2008 | EU032604.1 | ABS72351.1 |
| blaSHV-56 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ampicillin, amoxicillin +11 | Klebsiella pneumoniae +1 | France | 2008 | EU586041 | ACB73258.1 |
| blaSHV-109 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOTHIN +4 | Klebsiella pneumoniae | - | 2008 | EU418913.1 | ACM04459.1 |
| blaSHV-6 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | 1991 | DAGOBI010000132.1 | HBX2855210.1 |
| SHV | Reslit | 37 | cefpodoxime, cefotaxime +45 | Escherichia coli +15 | Manitoba, Taiwan, Malaysia, Iran, Vietnam, North of Iran, South Korea, Delhi, India, Egypt, South Western Nigeria, Karachi, India, Michigan, USA, South Asia|Southeast Asia|Sub-Saharan Africa|East Asia|North Africa and Middle East, Tanzania|Thailand|human|swine, Nigeria, Upper Egypt, Bangladesh, Balochistan, Norway|India, Europe|China|India|Pakistan|Switzerland|Thailand|USA|global, Central China|China, Jordan, Netherlands, China, Poland, Thailand, Ho Chi Minh City, Vietnam, Europe|China | 2007, 2010, 2011, 2013, 2015, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2025, 2026 | KY706079|KY706080|KY753816 | - |
| blaSHV-48 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, ceftriaxone +7 | Escherichia coli +1 | - | 2009 | DQ679961|AY263404|J194944|FJ483937 | AAP03063.1 |
| blaSHV-105 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, ceftriaxone +11 | Escherichia coli +1 | - | 2009 | DQ679961|AY263404|J194944|FJ483937 | ACI22621.1 |
| blaSHV-61 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOTHIN +4 | Klebsiella pneumoniae | - | 2009 | AJ866284.2 | CAI30650.2 |
| blaSHV-62 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | TICARCILLIN, CEPHALOTHIN +11 | Klebsiella pneumoniae +1 | West Africa|Conakry, Guinea, Tennessee, USA|East Tennessee, Ghana | 2009, 2018, 2023, 2025 | AJ866285.2 | CAI30651.2 |
| blaSHV-71 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOTHIN +5 | Klebsiella pneumoniae | Shanxi Province, China | 2009, 2020 | AM176546.2 | CAJ47126.2 |
| blaSHV-73 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, CEPHALOTHIN +10 | Klebsiella pneumoniae +1 | Ghana, Sub-Saharan Africa | 2009, 2021, 2025 | AM176548.2 | CAJ47128.2 |
| blaSHV-74 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOTHIN +4 | Klebsiella pneumoniae | - | 2009 | AM176549.2 | CAJ47129.2 |
| blaSHV-75 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOTHIN +4 | Klebsiella pneumoniae | - | 2009 | AM176550.2 | CAJ47130.2 |
| blaSHV-76 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOTHIN +5 | Klebsiella pneumoniae | Oman | 2009, 2023 | AM176551.2 | CAJ47131.2 |
| blaSHV-77 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOTHIN +4 | Klebsiella pneumoniae +1 | - | 2009 | AM176552.2 | CAJ47132.2 |
| blaSHV-78 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOTHIN +5 | Klebsiella pneumoniae +1 | Nigeria | 2009, 2024 | AM176553.2 | CAJ47133.2 |
| blaSHV-79 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOTHIN +9 | Klebsiella pneumoniae +1 | United States | 2009, 2024 | AM176554.2 | CAJ47134.2 |
| blaSHV-80 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOTHIN +9 | Klebsiella pneumoniae +1 | India | 2009, 2025 | AM176555.2 | CAJ47135.2 |
| blaSHV-81 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, CEPHALOTHIN +11 | Klebsiella pneumoniae | Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, China | 2009, 2021, 2023 | AM176556.2 | CAJ47136.2 |
| blaSHV-82 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOTHIN +7 | Klebsiella pneumoniae | Djibouti | 2009, 2025 | AM176557.2 | CAJ47137.2 |
| blaSHV-110 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | BETA-LACTAM, UNKNOWN BETA-LACTAM +4 | Klebsiella pneumoniae | Iran | 2009, 2016, 2023 | HQ877615.1 | AEK48094.1 |
| blaSHV-111 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2009 | AB372881.1 | BAF95849.1 |
| blaSHV-84 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Escherichia coli | - | 2010 | DAGGVK010000093.1 | HBU8836957.1 |
| blaSHV-86 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Klebsiella pneumoniae | - | 2010 | DQ328802.1 | ABC58727.1 |
| blaSHV-52 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 1990 | HQ845196.1 | AEJ08681.1 |
| blaSHV-1(L138P) | Reslit | 1 | penicillin, ampicillin | Escherichia coli +1 | - | 2011 | AM849806|EU342351 | - |
| blaSHV-122b | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | 2011 | HM751103.1 | ADR80609.1 |
| blaSHV-95 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Citrobacter freundii | - | 2011 | EF373972.1 | ABN49113.1 |
| blaSHV-100 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | AZTREONAM, TICARCILLIN +12 | Klebsiella pneumoniae +1 | United Kingdom|Ireland, Houston, Europe|Asia|North America|Western and South-Eastern Asia, Mexico|Mexico City | 2011, 2017, 2020, 2023 | AM941846.1 | CAQ03505.1 |
| blaSHV-98 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | AZTREONAM, TICARCILLIN +12 | Klebsiella pneumoniae +1 | Egypt, Nigeria | 2011, 2023, 2024 | AM941844.1 | CAQ03503.1 |
| blaSHV-99 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | AZTREONAM, TICARCILLIN +14 | Klebsiella pneumoniae +2 | Iran, Netherlands, West Bengal, India | 2011, 2016, 2018, 2025 | AM941845.1 | CAQ03504.1 |
| bla(SHV) | Reslit | 2 | ceftazidime, ceftriaxone +4 | Escherichia coli +1 | North-India, China | 2011, 2021 | - | - |
| blaSHV-97 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | cefoxitin, cefotaxime +2 | Escherichia coli +1 | China | 2012 | EF373973.1 | ABN49114.1 |
| blaSHV-134 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | AZTREONAM, TICARCILLIN +10 | Klebsiella pneumoniae +1 | Peru | 2012, 2022 | HM559945.1 | ADM25824.1 |
| blaSHV-129 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | ceftazidime, cefotaxime +14 | Escherichia coli +1 | Italy|Greece, Asia|Latin America|Middle East|North America|South Pacific|Africa|Europe|South Africa|China, La Paz River basin, Bolivia|La Paz River basin | 2012, 2013, 2015, 2016, 2022 | GU827715|HM066995 | ADE08533.1 |
| blaSHV-142 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2012 | JQ029959.1 | AEX99752.1 |
| blaSHV-168 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +3 | Klebsiella pneumoniae | Djibouti | 2013, 2025 | JX870080.1 | AFW16978.1 |
| blaSHV-147 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2013 | JX121114.1 | AFQ23953.1 |
| blaSHV-148 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN +1 | Klebsiella pneumoniae +1 | India | 2013, 2016 | JX121115.1 | AFQ23954.1 |
| blaSHV-149 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2013 | JX121116.1 | AFQ23955.1 |
| blaSHV-150 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2013 | JX121117.1 | AFQ23956.1 |
| blaSHV-151 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2013 | JX121118.1 | AFQ23957.1 |
| blaSHV-152 | Card DatabaseReference Gene CatalogResFinder Database | 4 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Klebsiella pneumoniae | - | 2013 | JX121119.1 | AFQ23958.1 |
| blaSHV-153 | Card DatabaseReference Gene CatalogResFinder Database | 4 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Klebsiella pneumoniae | - | 2013 | JX121120.1 | AFQ23959.1 |
| blaSHV-154 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN +4 | Klebsiella pneumoniae +3 | Western Pennsylvania | 2013, 2014, 2015 | JX121121.1 | AFQ23960.1 |
| blaSHV-155 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2013 | JX121122.1 | AFQ23961.1 |
| blaSHV-156 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2013 | JX121123.1 | AFQ23962.1 |
| blaSHV-157 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2013 | JX121124.1 | AFQ23963.1 |
| blaSHV-158 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +4 | Klebsiella pneumoniae | South Korea | 2013, 2017 | JX121125.1 | AFQ23964.1 |
| blaSHV-159 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2013 | JX121126.1 | AFQ23965.1 |
| blaSHV-160 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN +1 | Klebsiella pneumoniae +2 | Michigan|United States | 2013, 2023 | JX121127.1 | AFQ23966.1 |
| blaSHV-161 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +2 | Klebsiella pneumoniae +1 | - | 2013, 2015 | JX121128.1 | AFQ23967.1 |
| blaSHV-162 | Card DatabaseReference Gene CatalogResFinder Database | 4 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Klebsiella pneumoniae | - | 2013 | JX121129.1 | AFQ23968.1 |
| blaSHV-163 | Card DatabaseReference Gene CatalogResFinder Database | 4 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Klebsiella pneumoniae | - | 2013 | JX121130.1 | AFQ23969.1 |
| blaSHV-165 | Card DatabaseReference Gene CatalogResFinder Database | 4 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Klebsiella pneumoniae | - | 2013 | JX121131.1 | AFQ23970.1 |
| blaSHV-135 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | amoxicillin, BETA-LACTAM +1 | Klebsiella pneumoniae +1 | UK | 2013 | NC_004431.1|NC_009653 | ADR66517.1 |
| bla_SHV | Reslit | 4 | ampicillin, piperacillin tazobactam +10 | Klebsiella pneumoniae +2 | Iran, China, Egypt | 2013, 2023, 2024 | MW582865 | - |
| SHV-ESBL | Reslit | 1 | ceftazidime, cefotaxime +1 | Escherichia coli | Netherlands|Asia|South Asia|East Asia | 2013 | - | - |
| blaSHV-144 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2013 | JQ926986.1 | AFK93491.1 |
| blaSHV-133 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +1 | Klebsiella pneumoniae | Malawi | 2014, 2019 | AB551737.1 | BAI94487.1 |
| blaSHV-104 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | cephalosporins, penicillin +10 | Klebsiella pneumoniae +1 | Tunisia | 2014 | EU274581 | ABX71158.1 |
| blaSHV-S130G | Reslit | 1 | beta lactams | Escherichia coli +1 | - | 2014 | 3D4F|1TDG | - |
| blaSHV-231 | Card DatabaseReference Gene CatalogReslit | 3 | BETA-LACTAM, aztreonam | Klebsiella pneumoniae +1 | Argentina | 2015, 2025 | OP951208.1 | WAK12382.1 |
| blaSHV-233 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | 2015 | OR826346.1 | WPL92335.1 |
| blaSHV-238 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | 2015 | OR880707.1 | WPO27054.1 |
| blaSHV-141 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, aztreonam +6 | Escherichia coli +1 | - | 2015 | JQ388884.1 | AFC60795.1 |
| blaSHV-128 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, cefotaxime +11 | Enterobacter cloacae +1 | Tunisia | 2015 | GU932590 | ADE58494.1 |
| blaSHV-143 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2015 | JQ341060.1 | AFQ32277.1 |
| shv | Reslit | 5 | penicillin, cephalosporins +3 | Enterobacteriaceae +6 | Germany, Egypt, Singapore | 2015, 2017, 2021, 2024 | KX214665|KX214664|KX214663|KX214662 | - |
| blaSHV-119 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2015 | KJ776406.1 | AIG51284.1 |
| blaSHV-175 | Reference Gene Catalog | 1 | BETA-LACTAM | - | - | 2015 | WMLX01000003.1 | - |
| blaSHV-45 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | AZTREONAM, TICARCILLIN +10 | Klebsiella pneumoniae +1 | West Bengal, India | 2015, 2025 | AF547625.1 | AAN39364.1 |
| blaSHV-120 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN +1 | Escherichia coli | Jakarta | 2016, 2020 | JF812965.1 | AEG79634.1 |
| blaSHV-5/12 | Reslit | 1 | cephalosporins, penicillin | Escherichia coli | Tanzania | 2016 | - | - |
| blaSHV-187 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | cefepime, ceftazidime +10 | Klebsiella pneumoniae +2 | South Korea, Shanxi Province, China, Europe, Germany, China, United States, Beijing | 2017, 2020, 2021, 2022, 2023, 2024 | LYPQ00000000|LYPS00000000|LDWV00000000|LYPU00000000|LYPT00000000|LYPV00000000|LYPW00000000 | CEA29750.1 |
| blaSHV -28 | Reslit | 1 | cefotaxime, ceftazidime +1 | Klebsiella pneumoniae | Cameroon | 2018 | PDVM00000000|PDVF00000000|PDVG00000000|PDVC00000000|PDVE00000000|PDVU00000000|PDVD00000000 | - |
| blaSHV -11 | Reslit | 1 | cefotaxime, ceftazidime +1 | Klebsiella pneumoniae | Cameroon | 2018 | PDVM00000000|PDVF00000000|PDVG00000000|PDVC00000000|PDVE00000000|PDVU00000000|PDVD00000000 | - |
| blaSHV -27 | Reslit | 1 | cefotaxime, ceftazidime +1 | Klebsiella pneumoniae | Cameroon | 2018 | PDVM00000000|PDVF00000000|PDVG00000000|PDVC00000000|PDVE00000000|PDVU00000000|PDVD00000000 | - |
| blaSHV -1 | Reslit | 1 | cefotaxime, ceftazidime +1 | Klebsiella pneumoniae | Cameroon | 2018 | PDVM00000000|PDVF00000000|PDVG00000000|PDVC00000000|PDVE00000000|PDVU00000000|PDVD00000000 | - |
| blaSHV -134 | Reslit | 1 | cefotaxime, ceftazidime +1 | Klebsiella pneumoniae | Cameroon | 2018 | PDVM00000000|PDVF00000000|PDVG00000000|PDVC00000000|PDVE00000000|PDVU00000000|PDVD00000000 | - |
| blaSHV -12 | Reslit | 1 | cefoxitin, cefotaxime +2 | Salmonella enterica | United Kingdom | 2018 | NCBI Short Read Archive under the BioProject PRJNA315192 | - |
| blaSHV–11 | Reslit | 1 | ampicillin, amoxicillin clavulanic acid +1 | Klebsiella pneumoniae | - | 2019 | - | - |
| blaSHV-9 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | cefotaxime, ceftriaxone +13 | Klebsiella pneumoniae | Saudi Arabia | 1996, 2019 | S82452.1 | AAB37395.2 |
| blaSHV-ESBL | Reslit | 1 | ceftazidime, cefotaxime +1 | Klebsiella pneumoniae | Chicago|Illinois | 2020 | - | - |
| blaSHV-137 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2020 | HQ661363.1 | AEI83430.1 |
| blaSHV-145 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | BETA-LACTAM, UNKNOWN BETA-LACTAM +4 | Klebsiella pneumoniae +1 | Germany, Nigeria | 2020, 2022, 2023, 2024 | JX013655.1 | AFN88952.1 |
| blaSHV-like | Reslit | 2 | ampicillin, cephalothin +2 | Klebsiella pneumoniae +1 | Brazil | 2020, 2025 | - | - |
| bla_SHV-11 | Reslit | 2 | cephalosporins | Escherichia coli +1 | India, Vietnam | 2020, 2021 | MN370028|MN715313|MN715314 | - |
| blaSHV-ESBLs | Reslit | 1 | ceftazidime | Klebsiella pneumoniae | Houston | 2020 | - | - |
| bla_SHV-12 | Reslit | 4 | cefoxitin, cephalothin +6 | Enterobacter hormaechei +3 | Australia, Vietnam, New South Wales, Australia | 2020, 2021, 2022 | CP040117|CP040118|CP05031|CP050312|CP050506|CP050507 | - |
| blaSHV–1 | Reslit | 2 | cefoxitin, ceftriaxone +4 | Klebsiella pneumoniae +1 | China | 2020, 2022 | CP051490|CP051491|CP051492 | - |
| blaSHV-59 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2021 | AY790341.1 | AAV66328.1 |
| blaSHV– 106 | Reslit | 1 | cefoxitin, ceftriaxone +5 | Klebsiella pneumoniae | Romania | 2020 | PRJNA579879 | - |
| blaSHV-51 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | 2021 | AY289548.1 | AAP41944.1 |
| bla_SHV-106 | Reslit | 1 | cephalosporins | Enterobacterales | Vietnam | 2021 | AP018565|AP018566|AP018567|AP018568|AP018571|AP018572|AP018577|AP018578|AP018579|AP018580|AP018581|AP018582|AP018583|AP018584|CP021952|CP040884|CP041930|CP043383|CP034846|CP026053|CP041177|PRJDB6655 | - |
| bla_SHV-28 | Reslit | 1 | cephalosporins | Enterobacterales | Vietnam | 2021 | AP018565|AP018566|AP018567|AP018568|AP018571|AP018572|AP018577|AP018578|AP018579|AP018580|AP018581|AP018582|AP018583|AP018584|CP021952|CP040884|CP041930|CP043383|CP034846|CP026053|CP041177|PRJDB6655 | - |
| blaSHV–12 | Reslit | 3 | cephalosporins, penicillin +6 | Klebsiella pneumoniae +1 | China, Finland|Eastern Finland | 2021, 2022 | CP040833|CP040834|CP040835|CP040836|CP040837|CP040838|CP040839 | - |
| blaSHV-2/2a | Reslit | 1 | cefoxitin, cefotaxime +2 | Klebsiella pneumoniae | Cambodia | 2022 | PRJEB25898 | - |
| bla(SHV-12) | Reslit | 2 | ceftazidime, ampicillin +8 | Escherichia coli +1 | Australia, China | 2022, 2024 | CP094826.1 | - |
| blaSHV–158 | Reslit | 1 | ceftazidime, ceftriaxone +4 | Klebsiella pneumoniae | - | 2022 | - | - |
| blaSHV–106 | Reslit | 1 | ceftazidime, ceftriaxone +4 | Klebsiella pneumoniae | - | 2022 | - | - |
| blaSHV–187 | Reslit | 1 | ceftazidime, ceftriaxone +4 | Klebsiella pneumoniae | - | 2022 | - | - |
| blaSHV-234 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | 2022 | OR863406.1 | WPM90266.1 |
| blaSHV-235 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | 2022 | OR863407.1 | WPM90267.1 |
| blaSHV-237 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | 2022 | OR863410.1 | WPM90269.1 |
| blaSHV-232 | Card DatabaseReference Gene CatalogReslit | 3 | ceftazidime, cefotaxime +1 | Klebsiella pneumoniae | Wales|Nigeria | 2023 | OR224963|OR224962 | WKB12817.1 |
| bla_SHV-1 | Reslit | 1 | cephalosporins | Klebsiella pneumoniae | China | 2024 | CP089987.1|CP089991.1|PRJNA787439 | - |
| blaSHV-230 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Escherichia coli | - | 2024 | OP762696.1 | UZV42324.1 |
| blaSHV-176 | Reslit | 1 | cefotaxime, ceftazidime | Klebsiella pneumoniae | Algeria | 2024 | - | - |
| Shv | Reslit | 1 | ampicillin, amoxicillin +1 | Enterobacteriaceae | Jordan | 2025 | - | - |
| blaSHV -ESBL | Reslit | 1 | beta lactams | Enterobacterales +2 | Europe | 2025 | Supplementary Table S1 | - |
An SHV-derived extended-spectrum beta-lactamase in Pseudomonas aeruginosa.
The study identifies SHV-2a, an extended-spectrum beta-lactamase in Pseudomonas aeruginosa, which confers resistance to ceftazidime, cefotaxime, and aztreonam.
Bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a pediatric oncology ward: clinical features and identification of different plasmids carrying both SHV-5 and TEM-1 genes.
The study identifies SHV-5 and TEM-1 beta-lactamase genes in extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates from a pediatric oncology ward, highlighting their role in resistance to various beta-lactam antibiotics.
Detection and reporting of organisms producing extended-spectrum beta-lactamases: survey of laboratories in Connecticut.
The study identified and characterized several extended-spectrum beta-lactamases (ESBLs), including SHV-8, SHV-4, SHV-5, and AmpC, which confer resistance to extended-spectrum cephalosporins and aztreonam. The research highlighted challenges in detecting these resistance mechanisms in clinical laboratories.
Detection and reporting of organisms producing extended-spectrum beta-lactamases: survey of laboratories in Connecticut.
The study identified and characterized several extended-spectrum beta-lactamases (ESBLs), including SHV-8, SHV-4, SHV-5, and AmpC, which confer resistance to extended-spectrum cephalosporins and aztreonam. The research highlighted challenges in detecting these resistance mechanisms in clinical laboratories.
Detection and reporting of organisms producing extended-spectrum beta-lactamases: survey of laboratories in Connecticut.
The study identified and characterized several extended-spectrum beta-lactamases (ESBLs), including SHV-8, SHV-4, SHV-5, and AmpC, which confer resistance to extended-spectrum cephalosporins and aztreonam. The research highlighted challenges in detecting these resistance mechanisms in clinical laboratories.
Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes.
Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes.
Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes.
Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes.
Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes.
Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes.
Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes.
Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes.
High-level expression of chromosomally encoded SHV-1 beta-lactamase and an outer membrane protein change confer resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniae.
The study identifies that high-level resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniae is due to high-level expression of chromosomally encoded SHV-1 beta-lactamase and a decrease in a minor outer membrane protein.
Characterisation of extended-spectrum beta-lactamases of the SHV family using a combination of PCR-single strand conformational polymorphism (PCR-SSCP) and PCR-restriction fragment length polymorphism (PCR-RFLP).
Characterisation of extended-spectrum beta-lactamases of the SHV family using a combination of PCR-single strand conformational polymorphism (PCR-SSCP) and PCR-restriction fragment length polymorphism (PCR-RFLP).
Characterisation of extended-spectrum beta-lactamases of the SHV family using a combination of PCR-single strand conformational polymorphism (PCR-SSCP) and PCR-restriction fragment length polymorphism (PCR-RFLP).
SHV-13, a novel extended-spectrum beta-lactamase, in Klebsiella pneumoniae isolates from patients in an intensive care unit in Amsterdam.
SHV-13, a novel extended-spectrum beta-lactamase, in Klebsiella pneumoniae isolates from patients in an intensive care unit in Amsterdam.
SHV-13, a novel extended-spectrum beta-lactamase, in Klebsiella pneumoniae isolates from patients in an intensive care unit in Amsterdam.
SHV-13, a novel extended-spectrum beta-lactamase, in Klebsiella pneumoniae isolates from patients in an intensive care unit in Amsterdam.
Prevalence of SHV-12 among clinical isolates of Klebsiella pneumoniae producing extended-spectrum beta-lactamases and identification of a novel AmpC enzyme (CMY-8) in Southern Taiwan.
The study identifies SHV-12 as a prevalent extended-spectrum beta-lactamase in Klebsiella pneumoniae isolates and characterizes a novel AmpC beta-lactamase, CMY-8, which confers resistance to cephalosporins and cephamycins.
A new SHV-derived extended-spectrum beta-lactamase (SHV-24) that hydrolyzes ceftazidime through a single-amino-acid substitution (D179G) in the -loop.
The study identifies a novel SHV-derived extended-spectrum beta-lactamase, SHV-24, which confers high-level resistance to ceftazidime through a single amino acid substitution (D179G) in the omega-loop of the enzyme.
A new SHV-derived extended-spectrum beta-lactamase (SHV-24) that hydrolyzes ceftazidime through a single-amino-acid substitution (D179G) in the -loop.
A new SHV-derived extended-spectrum beta-lactamase (SHV-24) that hydrolyzes ceftazidime through a single-amino-acid substitution (D179G) in the -loop.
A new SHV-derived extended-spectrum beta-lactamase (SHV-24) that hydrolyzes ceftazidime through a single-amino-acid substitution (D179G) in the -loop.
A new SHV-derived extended-spectrum beta-lactamase (SHV-24) that hydrolyzes ceftazidime through a single-amino-acid substitution (D179G) in the -loop.
Rapid discriminatory detection of genes coding for SHV beta-lactamases by ligase chain reaction.
The study developed a ligase chain reaction (LCR) method to identify and differentiate SHV beta-lactamase genes, including SHV-1, SHV-2, SHV-2a, SHV-3, SHV-4, SHV-5, and SHV-12, based on specific point mutations. This method enables rapid and accurate detection of these genes in clinical isolates.
Rapid discriminatory detection of genes coding for SHV beta-lactamases by ligase chain reaction.
The study developed a ligase chain reaction (LCR) method to identify and differentiate SHV beta-lactamase genes, including SHV-1, SHV-2, SHV-2a, SHV-3, SHV-4, SHV-5, and SHV-12, based on specific point mutations. This method enables rapid and accurate detection of these genes in clinical isolates.
Rapid discriminatory detection of genes coding for SHV beta-lactamases by ligase chain reaction.
The study developed a ligase chain reaction (LCR) method to identify and differentiate SHV beta-lactamase genes, including SHV-1, SHV-2, SHV-2a, SHV-3, SHV-4, SHV-5, and SHV-12, based on specific point mutations. This method enables rapid and accurate detection of these genes in clinical isolates.
Rapid discriminatory detection of genes coding for SHV beta-lactamases by ligase chain reaction.
The study developed a ligase chain reaction (LCR) method to identify and differentiate SHV beta-lactamase genes, including SHV-1, SHV-2, SHV-2a, SHV-3, SHV-4, SHV-5, and SHV-12, based on specific point mutations. This method enables rapid and accurate detection of these genes in clinical isolates.
Rapid discriminatory detection of genes coding for SHV beta-lactamases by ligase chain reaction.
The study developed a ligase chain reaction (LCR) method to identify and differentiate SHV beta-lactamase genes, including SHV-1, SHV-2, SHV-2a, SHV-3, SHV-4, SHV-5, and SHV-12, based on specific point mutations. This method enables rapid and accurate detection of these genes in clinical isolates.
Rapid discriminatory detection of genes coding for SHV beta-lactamases by ligase chain reaction.
The study developed a ligase chain reaction (LCR) method to identify and differentiate SHV beta-lactamase genes, including SHV-1, SHV-2, SHV-2a, SHV-3, SHV-4, SHV-5, and SHV-12, based on specific point mutations. This method enables rapid and accurate detection of these genes in clinical isolates.
Rapid discriminatory detection of genes coding for SHV beta-lactamases by ligase chain reaction.
The study developed a ligase chain reaction (LCR) method to identify and differentiate SHV beta-lactamase genes, including SHV-1, SHV-2, SHV-2a, SHV-3, SHV-4, SHV-5, and SHV-12, based on specific point mutations. This method enables rapid and accurate detection of these genes in clinical isolates.
Prevalence of beta-lactamases among 1,072 clinical strains of Proteus mirabilis: a 2-year survey in a French hospital.
The study identified various beta-lactamase genes including TEM-1, TEM-2, TEM-3, TEM-66, CARB-2, SHV-1, IRT-13, IRT-16, and IRT-2 in Proteus mirabilis strains, highlighting their role in beta-lactam resistance.
Characterization of the extended-spectrum beta-lactamase reference strain, Klebsiella pneumoniae K6 (ATCC 700603), which produces the novel enzyme SHV-18.
The study characterizes the novel extended-spectrum beta-lactamase SHV-18 produced by Klebsiella pneumoniae K6, which confers resistance to ceftazidime, cefotaxime, and aztreonam.
Characterization of the extended-spectrum beta-lactamase reference strain, Klebsiella pneumoniae K6 (ATCC 700603), which produces the novel enzyme SHV-18.
Characterization of the extended-spectrum beta-lactamase reference strain, Klebsiella pneumoniae K6 (ATCC 700603), which produces the novel enzyme SHV-18.
Characterization of the extended-spectrum beta-lactamase reference strain, Klebsiella pneumoniae K6 (ATCC 700603), which produces the novel enzyme SHV-18.
Characterization of the extended-spectrum beta-lactamase reference strain, Klebsiella pneumoniae K6 (ATCC 700603), which produces the novel enzyme SHV-18.
ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci.
ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci.
ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci.
Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum beta-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla TEM-53, bla TEM-63, and novel bla SHV variants (SHV-19 to SHV-22), in Klebsiella pneumoniae isolates from a South African hospital.
Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum beta-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla TEM-53, bla TEM-63, and novel bla SHV variants (SHV-19 to SHV-22), in Klebsiella pneumoniae isolates from a South African hospital.
Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum beta-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla TEM-53, bla TEM-63, and novel bla SHV variants (SHV-19 to SHV-22), in Klebsiella pneumoniae isolates from a South African hospital.
Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum beta-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla TEM-53, bla TEM-63, and novel bla SHV variants (SHV-19 to SHV-22), in Klebsiella pneumoniae isolates from a South African hospital.
Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum beta-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa.
Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum beta-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa.
SHV-14, a novel beta-lactamase variant in Klebsiella pneumoniae isolates from Nijmegen, The Netherlands.
The study identifies SHV-14, a novel beta-lactamase variant in Klebsiella pneumoniae isolates, and TEM-29, a known extended-spectrum beta-lactamase, as contributors to beta-lactam resistance.
SHV-14, a novel beta-lactamase variant in Klebsiella pneumoniae isolates from Nijmegen, The Netherlands.
SHV-14, a novel beta-lactamase variant in Klebsiella pneumoniae isolates from Nijmegen, The Netherlands.
SHV-14, a novel beta-lactamase variant in Klebsiella pneumoniae isolates from Nijmegen, The Netherlands.
SHV-14, a novel beta-lactamase variant in Klebsiella pneumoniae isolates from Nijmegen, The Netherlands.
Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.
Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.
Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.
Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.
SHV-27, a novel cefotaxime-hydrolysing beta-lactamase, identified in Klebsiella pneumoniae isolates from a Brazilian hospital.
SHV-27, a novel cefotaxime-hydrolysing beta-lactamase, identified in Klebsiella pneumoniae isolates from a Brazilian hospital.
SHV-27, a novel cefotaxime-hydrolysing beta-lactamase, identified in Klebsiella pneumoniae isolates from a Brazilian hospital.
SHV-27, a novel cefotaxime-hydrolysing beta-lactamase, identified in Klebsiella pneumoniae isolates from a Brazilian hospital.
Real-time PCR and melting curve analysis for reliable and rapid detection of SHV extended-spectrum beta-lactamases.
The study describes a real-time PCR and melting curve analysis method for detecting SHV extended-spectrum beta-lactamases, which are responsible for resistance to expanded-spectrum cephalosporins.
Coexistence of SHV-4- and TEM-24-producing Enterobacter aerogenes strains before a large outbreak of TEM-24-producing strains in a French hospital.
The study identifies the presence of SHV-4 and TEM-24 extended-spectrum beta-lactamase-producing Enterobacter aerogenes strains in a French hospital before a large outbreak of TEM-24-producing strains. Both genes were experimentally validated for their resistance mechanisms.
Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae.
The study identifies a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae. IMP-8 differs from IMP-2 by four nucleotide substitutions leading to two amino acid changes and is carried on an integron-borne gene cassette.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
The study identifies two novel beta-lactamases, SHV-25 and SHV-26, in Klebsiella pneumoniae isolates from northern Taiwan. SHV-25 is a non-ESBL, while SHV-26 exhibits reduced susceptibility to clavulanic acid.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
The study identifies two novel beta-lactamases, SHV-25 and SHV-26, in Klebsiella pneumoniae isolates from northern Taiwan. SHV-25 is a non-ESBL, while SHV-26 exhibits reduced susceptibility to clavulanic acid.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
The study identifies two novel beta-lactamases, SHV-25 and SHV-26, in Klebsiella pneumoniae isolates from northern Taiwan. SHV-25 is a non-ESBL, while SHV-26 exhibits reduced susceptibility to clavulanic acid.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
The study identifies two novel beta-lactamases, SHV-25 and SHV-26, in Klebsiella pneumoniae isolates from northern Taiwan. SHV-25 is a non-ESBL, while SHV-26 exhibits reduced susceptibility to clavulanic acid.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
The study identifies two novel beta-lactamases, SHV-25 and SHV-26, in Klebsiella pneumoniae isolates from northern Taiwan. SHV-25 is a non-ESBL, while SHV-26 exhibits reduced susceptibility to clavulanic acid.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
The study identifies two novel beta-lactamases, SHV-25 and SHV-26, in Klebsiella pneumoniae isolates from northern Taiwan. SHV-25 is a non-ESBL, while SHV-26 exhibits reduced susceptibility to clavulanic acid.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
The study identifies two novel beta-lactamases, SHV-25 and SHV-26, in Klebsiella pneumoniae isolates from northern Taiwan. SHV-25 is a non-ESBL, while SHV-26 exhibits reduced susceptibility to clavulanic acid.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
SHV-16, a beta-lactamase with a pentapeptide duplication in the omega loop.
The study identifies SHV-16, a novel extended-spectrum beta-lactamase with a pentapeptide duplication in the omega loop, which confers high-level resistance to ceftazidime.
SHV-16, a beta-lactamase with a pentapeptide duplication in the omega loop.
SHV-16, a beta-lactamase with a pentapeptide duplication in the omega loop.
SHV-16, a beta-lactamase with a pentapeptide duplication in the omega loop.
SHV-16, a beta-lactamase with a pentapeptide duplication in the omega loop.
SHV-1 beta-lactamase Is Mainly a Chromosomally Encoded Species-Specific Enzyme in Klebsiella pneumoniae.
The study identifies SHV-1, SHV-32, and SHV-33 beta-lactamases as chromosomally encoded enzymes in Klebsiella pneumoniae, demonstrating their role in resistance to various β-lactam antibiotics.
SHV-1 beta-lactamase Is Mainly a Chromosomally Encoded Species-Specific Enzyme in Klebsiella pneumoniae.
The study identifies SHV-1, SHV-32, and SHV-33 beta-lactamases as chromosomally encoded enzymes in Klebsiella pneumoniae, demonstrating their role in resistance to various β-lactam antibiotics.
SHV-1 beta-lactamase Is Mainly a Chromosomally Encoded Species-Specific Enzyme in Klebsiella pneumoniae.
The study identifies SHV-1, SHV-32, and SHV-33 beta-lactamases as chromosomally encoded enzymes in Klebsiella pneumoniae, demonstrating their role in resistance to various β-lactam antibiotics.
SHV-1 beta-lactamase is mainly a chromosomally encoded species-specific enzyme in Klebsiella pneumoniae.
SHV-1 beta-lactamase is mainly a chromosomally encoded species-specific enzyme in Klebsiella pneumoniae.
SHV-1 beta-lactamase is mainly a chromosomally encoded species-specific enzyme in Klebsiella pneumoniae.
SHV-1 beta-lactamase is mainly a chromosomally encoded species-specific enzyme in Klebsiella pneumoniae.
SHV-1 beta-lactamase is mainly a chromosomally encoded species-specific enzyme in Klebsiella pneumoniae.
SHV-1 beta-lactamase is mainly a chromosomally encoded species-specific enzyme in Klebsiella pneumoniae.
SHV-1 beta-lactamase is mainly a chromosomally encoded species-specific enzyme in Klebsiella pneumoniae.
SHV-1 beta-lactamase is mainly a chromosomally encoded species-specific enzyme in Klebsiella pneumoniae.
Detection of Extended-Spectrum Beta-Lactamases in Clinical Isolates
The study identifies various SHV-type beta-lactamase genes, including SHV-1, SHV-2, SHV-3, SHV-4, SHV-5, and SHV-7, which confer resistance to ceftazidime. These genes were detected using PCR-RFLP and PCR-SSCP techniques.
Genes encoding TEM-4, SHV-2, and CTX-M-10 extended-spectrum beta-lactamases are carried by multiple Klebsiella pneumoniae clones in a single hospital (Madrid, 1989 to 2000).
The study identifies multiple Klebsiella pneumoniae clones carrying TEM-4, SHV-2, SHV-2a, SHV-5, CTX-M-10, and CTX-M-9 extended-spectrum beta-lactamases, highlighting the clonal diversity and spread of these resistance genes in a single hospital over a 12-year period.
Genes encoding TEM-4, SHV-2, and CTX-M-10 extended-spectrum beta-lactamases are carried by multiple Klebsiella pneumoniae clones in a single hospital (Madrid, 1989 to 2000).
The study identifies multiple Klebsiella pneumoniae clones carrying TEM-4, SHV-2, SHV-2a, SHV-5, CTX-M-10, and CTX-M-9 extended-spectrum beta-lactamases, highlighting the clonal diversity and spread of these resistance genes in a single hospital over a 12-year period.
Genes encoding TEM-4, SHV-2, and CTX-M-10 extended-spectrum beta-lactamases are carried by multiple Klebsiella pneumoniae clones in a single hospital (Madrid, 1989 to 2000).
The study identifies multiple Klebsiella pneumoniae clones carrying TEM-4, SHV-2, SHV-2a, SHV-5, CTX-M-10, and CTX-M-9 extended-spectrum beta-lactamases, highlighting the clonal diversity and spread of these resistance genes in a single hospital over a 12-year period.
Three cefotaximases, CTX-M-9, CTX-M-13, and CTX-M-14, among Enterobacteriaceae in the People's Republic of China.
The study identifies three CTX-M beta-lactamases (CTX-M-9, CTX-M-13, and CTX-M-14) and SHV-12 as significant contributors to extended-spectrum beta-lactamase (ESBL) resistance in Enterobacteriaceae in China.
Identification and minisequencing-based discrimination of SHV beta-lactamases in nosocomial infection-associated Klebsiella pneumoniae in Brisbane, Australia.
The study identified and characterized SHV beta-lactamase variants, including blaSHV-2a and blaSHV-12, which confer resistance to oxyimino cephalosporins and monobactams, while blaSHV-11 and blaSHV-1 do not.
Identification and minisequencing-based discrimination of SHV beta-lactamases in nosocomial infection-associated Klebsiella pneumoniae in Brisbane, Australia.
The study identified and characterized SHV beta-lactamase variants, including blaSHV-2a and blaSHV-12, which confer resistance to oxyimino cephalosporins and monobactams, while blaSHV-11 and blaSHV-1 do not.
Bloodstream Infections by Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae in Children: Epidemiology and Clinical Outcome.
The study identifies several extended-spectrum beta-lactamases (ESBLs) including TEM-52, SHV-2a, TEM-88, CMY-1-like, and CTX-M-14 in Escherichia coli and Klebsiella pneumoniae isolates from children with bloodstream infections. These ESBLs confer resistance to various beta-lactam antibiotics.
Development of a sensitive and specific enzyme-linked immunosorbent assay for detecting and quantifying CMY-2 and SHV beta-lactamases.
The study developed sensitive and specific ELISAs for detecting and quantifying CMY-2 and SHV beta-lactamases, demonstrating their effectiveness in identifying these resistance enzymes in clinical isolates.
Novel plasmid-encoded class C beta-lactamase (MOX-2) in Klebsiella pneumoniae from Greece.
The study identifies a novel plasmid-encoded class C beta-lactamase, MOX-2, in a multidrug-resistant Klebsiella pneumoniae isolate from Greece, which exhibits high hydrolytic activity against various beta-lactam antibiotics.
Distribution of extended-spectrum beta-lactamases in clinical isolates of Enterobacteriaceae in Vietnam.
The study identified several extended-spectrum beta-lactamases, including bla TEM-1, bla SHV-2, bla VEB-1, bla CTX-M-14, and bla CTX-M-17, which confer resistance to various cephalosporins in Enterobacteriaceae isolates from Vietnam.
Amino acid substitutions at Ambler position Gly238 in the SHV-1 beta-lactamase: exploring sequence requirements for resistance to penicillins and cephalosporins.
The study identifies that amino acid substitutions at Ambler position Gly238 in the SHV-1 beta-lactamase confer resistance to penicillins and cephalosporins, with the Gly238Ala mutation showing the highest resistance.
Emergence in Klebsiella pneumoniae of a chromosome-encoded SHV beta-lactamase that compromises the efficacy of imipenem.
The study identifies a novel chromosome-encoded SHV-beta-lactamase, SHV-38, which hydrolyzes imipenem and ceftazidime, compromising the efficacy of these antibiotics against Klebsiella pneumoniae.
Emergence in Klebsiella pneumoniae of a chromosome-encoded SHV beta-lactamase that compromises the efficacy of imipenem.
Emergence in Klebsiella pneumoniae of a chromosome-encoded SHV beta-lactamase that compromises the efficacy of imipenem.
Emergence in Klebsiella pneumoniae of a chromosome-encoded SHV beta-lactamase that compromises the efficacy of imipenem.
Emergence in Klebsiella pneumoniae of a chromosome-encoded SHV beta-lactamase that compromises the efficacy of imipenem.
Clinical isolates of Enterobacteriaceae producing extended-spectrum beta-lactamases: prevalence of CTX-M-3 at a hospital in China.
The study identified CTX-M-3 and SHV-43 beta-lactamases as significant contributors to extended-spectrum beta-lactamase (ESBL) production in clinical isolates of Enterobacteriaceae in a Chinese hospital.
Clinical isolates of Enterobacteriaceae producing extended-spectrum beta-lactamases: prevalence of CTX-M-3 at a hospital in China.
Clinical isolates of Enterobacteriaceae producing extended-spectrum beta-lactamases: prevalence of CTX-M-3 at a hospital in China.
Clinical isolates of Enterobacteriaceae producing extended-spectrum beta-lactamases: prevalence of CTX-M-3 at a hospital in China.
Clinical isolates of Enterobacteriaceae producing extended-spectrum beta-lactamases: prevalence of CTX-M-3 at a hospital in China.
Patterns of resistance associated with integrons, the extended-spectrum beta-lactamase SHV-5 gene, and a multidrug efflux pump of Klebsiella pneumoniae causing a nosocomial outbreak.
The study identifies the SHV-5 extended-spectrum beta-lactamase gene and a gyrA mutation (Ser83Tyr) as key resistance mechanisms in a multidrug-resistant Klebsiella pneumoniae outbreak. The SHV-5 gene conferred resistance to ceftazidime and aztreonam, while the gyrA mutation contributed to ciprofloxacin resistance.
Characterization of clinical isolates of Enterobacteriaceae from Italy by the BD Phoenix extended-spectrum beta-lactamase detection method.
The study characterized ESBL-producing Enterobacteriaceae isolates from Italy, identifying bla TEM-1, bla SHV-1, and bla CTX-M genes as the primary resistance mechanisms against extended-spectrum cephalosporins.
Dissemination of SHV-12 and characterization of new AmpC-type beta-lactamase genes among clinical isolates of enterobacter species in Korea.
The study identified and characterized several new AmpC-type beta-lactamase genes, including blaEcloK992004.1, blaEcloK995120.1, blaEcloK99230, blaEareK9911729, blaEcloK9973, and blaEcloK9914325, which confer resistance to various beta-lactam antibiotics. Additionally, SHV-12 was identified as an extended-spectrum beta-lactamase.
Molecular epidemiology and characterization of plasmid-encoded beta-lactamases produced by Tunisian clinical isolates of Salmonella enterica serotype Mbandaka resistant to broad-spectrum cephalosporins.
The study identified plasmid-encoded beta-lactamases TEM-4, SHV-2a, and ACC-1a in Salmonella enterica serotype Mbandaka isolates resistant to broad-spectrum cephalosporins.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae in community and private health care centers.
The study identifies various extended-spectrum beta-lactamases (ESBLs) including TEM-24b, TEM-21, TEM-15, TEM-19, TEM-3, SHV-4, and CTX-M-1, which confer resistance to multiple beta-lactam antibiotics in Enterobacteriaceae isolates from community and private healthcare centers.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae in community and private health care centers.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae in community and private health care centers.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae in community and private health care centers.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae in community and private health care centers.
Extended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamases.
The study identified SHV- and CTX-M-type extended-spectrum beta-lactamases as the most prevalent in Klebsiella pneumoniae bloodstream isolates from seven countries, highlighting their significance in antibiotic resistance.
SHV-34: an extended-spectrum beta-lactamase encoded by an epidemic plasmid.
SHV-34: an extended-spectrum beta-lactamase encoded by an epidemic plasmid.
SHV-34: an extended-spectrum beta-lactamase encoded by an epidemic plasmid.
Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2.
Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2.
Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2.
Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2.
Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae.
The study identifies two novel oxacillinases, OXA-48 and OXA-47, which confer resistance to imipenem and ceftazidime, respectively, in a multidrug-resistant Klebsiella pneumoniae isolate.
Clonal and horizontal dissemination of Klebsiella pneumoniae expressing SHV-5 extended-spectrum beta-lactamase in a Mexican pediatric hospital.
The study identifies SHV-5 extended-spectrum beta-lactamase as a significant cause of resistance in Klebsiella pneumoniae isolates, highlighting its role in the clonal and horizontal dissemination of multidrug-resistant strains in a Mexican pediatric hospital.
Utility of NCCLS guidelines for identifying extended-spectrum beta-lactamases in non-Escherichia coli and non-Klebsiella spp. of Enterobacteriaceae.
The study evaluated the effectiveness of NCCLS guidelines for detecting extended-spectrum beta-lactamases (ESBLs) in non-E. coli and non-Klebsiella spp. of Enterobacteriaceae. It found that only a small percentage of isolates showed a CA effect, and only a few isolates had ESBL genes such as bla TEM and bla SHV.
Epidemiology and clinical features of infections caused by extended-spectrum beta-lactamase-producing Escherichia coli in nonhospitalized patients.
The study identifies CTX-M-9, TEM, and SHV extended-spectrum beta-lactamases as major contributors to antimicrobial resistance in Escherichia coli isolates from nonhospitalized patients.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Canadian hospitals, including novel variants such as TEM-115, TEM-120, SHV-40, SHV-41, and SHV-42, highlighting the diversity and emergence of these resistance mechanisms in Escherichia coli and Klebsiella spp.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Canadian hospitals, including novel variants such as TEM-115, TEM-120, SHV-40, SHV-41, and SHV-42, highlighting the diversity and emergence of these resistance mechanisms in Escherichia coli and Klebsiella spp.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Canadian hospitals, including novel variants such as TEM-115, TEM-120, SHV-40, SHV-41, and SHV-42, highlighting the diversity and emergence of these resistance mechanisms in Escherichia coli and Klebsiella spp.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Canadian hospitals, including novel variants such as TEM-115, TEM-120, SHV-40, SHV-41, and SHV-42, highlighting the diversity and emergence of these resistance mechanisms in Escherichia coli and Klebsiella spp.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Canadian hospitals, including novel variants such as TEM-115, TEM-120, SHV-40, SHV-41, and SHV-42, highlighting the diversity and emergence of these resistance mechanisms in Escherichia coli and Klebsiella spp.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Canadian hospitals, including novel variants such as TEM-115, TEM-120, SHV-40, SHV-41, and SHV-42, highlighting the diversity and emergence of these resistance mechanisms in Escherichia coli and Klebsiella spp.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Canadian hospitals, including novel variants such as TEM-115, TEM-120, SHV-40, SHV-41, and SHV-42, highlighting the diversity and emergence of these resistance mechanisms in Escherichia coli and Klebsiella spp.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Canadian hospitals, including novel variants such as TEM-115, TEM-120, SHV-40, SHV-41, and SHV-42, highlighting the diversity and emergence of these resistance mechanisms in Escherichia coli and Klebsiella spp.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
SHV-12-Like Extended-Spectrum-β-Lactamase-Producing Strains of Salmonella enterica Serotypes Babelsberg and Enteritidis Isolated in France among Infants Adopted from Mali.
The study identifies SHV-12-like extended-spectrum beta-lactamase-producing strains of Salmonella enterica serotypes Babelsberg and Enteritidis isolated in France among infants adopted from Mali. The SHV-12 beta-lactamase was found to confer resistance to cephalosporins, while TEM beta-lactamase conferred resistance to penicillins and cephalosporins.
Diversity and evolution of the class A chromosomal beta-lactamase gene in Klebsiella pneumoniae.
The study identified three families of class A chromosomal beta-lactamase genes in Klebsiella pneumoniae: SHV, LEN, and OKP. These genes confer resistance to beta-lactam antibiotics such as ampicillin, carbenicillin, and ticarcillin.
Molecular Epidemiology of Serratia marcescens in Two Hospitals in Danzig, Poland, over a 5-Year Period
The study identified CTX-M-3, TEM-47, and SHV-5 extended-spectrum beta-lactamases in Serratia marcescens isolates from two hospitals in Danzig, Poland, over a 5-year period. These enzymes conferred resistance to various beta-lactam antibiotics.
Klebsiella pneumoniae with multiple antimicrobial resistance
The study identified a Klebsiella pneumoniae strain producing SHV-4 beta-lactamase and lacking a 36 kDa outer membrane porin, contributing to resistance against carbapenems and other beta-lactam antibiotics.
Pediatric infection due to multiresistant Salmonella enterica serotype Infantis in Honduras.
The study reports the first detection of bla CTX-M-15 in Salmonella and identifies multiple beta-lactamase genes (bla TEM-1b, bla SHV-5, bla CTX-M-15, and bla CMY-2) in a multidrug-resistant Salmonella enterica serotype Infantis isolate from Honduras.
SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae.
The study identifies SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae, and SHV-11, a chromosomal penicillinase variant, both contributing to beta-lactam resistance.
SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae.
The study identifies SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae, and SHV-11, a chromosomal penicillinase variant, both contributing to beta-lactam resistance.
SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae.
SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae.
SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae.
SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae.
bla(SHV) Genes in Klebsiella pneumoniae: different allele distributions are associated with different promoters within individual isolates.
The study identifies blaSHV alleles with mutations at codons 238 and 240 that confer resistance to extended-spectrum beta-lactam antibiotics in Klebsiella pneumoniae isolates.
Extended-Spectrum beta-lactamase (ESBL) producing Enterobacter aerogenes phenotypically misidentified as Klebsiella pneumoniae or K. terrigena.
The study identifies TEM-5 and SHV-4 beta-lactamase genes in Enterobacter aerogenes isolates that were misclassified as Klebsiella pneumoniae or K. terrigena due to delayed biochemical test results. These genes confer resistance to ceftazidime and aztreonam.
Novel SHV-derived extended-spectrum beta-lactamase, SHV-57, that confers resistance to ceftazidime but not cefazolin.
The study identifies SHV-57, a novel extended-spectrum beta-lactamase that confers resistance to ceftazidime but not cefazolin.
Novel SHV-derived extended-spectrum beta-lactamase, SHV-57, that confers resistance to ceftazidime but not cefazolin.
Novel SHV-derived extended-spectrum beta-lactamase, SHV-57, that confers resistance to ceftazidime but not cefazolin.
Novel SHV-derived extended-spectrum beta-lactamase, SHV-57, that confers resistance to ceftazidime but not cefazolin.
Novel SHV-derived extended-spectrum beta-lactamase, SHV-57, that confers resistance to ceftazidime but not cefazolin.
Extended-spectrum beta-lactamases among Enterobacter isolates obtained in Tel Aviv, Israel.
The study identified the presence of extended-spectrum beta-lactamases (ESBLs) in Enterobacter isolates, including TEM-1, SHV-12, CTX-M-2, and CTX-M-26, which confer resistance to various beta-lactam antibiotics.
Survey of Enterobacteriaceae producing extended-spectrum beta-lactamases in a Slovak hospital: dominance of SHV-2a and characterization of TEM-132.
The study identified the dominant extended-spectrum beta-lactamase SHV-2a and characterized the novel TEM-132 enzyme in Enterobacteriaceae isolates from a Slovak hospital.
Extended-spectrum-beta-lactamase-producing Enterobacteriaceae in Yaounde, Cameroon.
The study identifies the ESBL SHV-12 for the first time in Cameroon, produced by various Enterobacteriaceae species including E. coli, K. pneumoniae, C. freundii, and E. cloacae.
Countrywide spread of community- and hospital-acquired extended-spectrum beta-lactamase (CTX-M-15)-producing Enterobacteriaceae in Lebanon.
The study identifies the widespread presence of CTX-M-15 and SHV-5a extended-spectrum beta-lactamases in Enterobacteriaceae in Lebanon, highlighting their role in resistance to ceftazidime and cefotaxime.
Development of a multiplex PCR and SHV melting-curve mutation detection system for detection of some SHV and CTX-M beta-lactamases of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae in Taiwan.
The study developed a multiplex PCR and SHV melting-curve mutation detection system to identify SHV and CTX-M beta-lactamases in Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae. SHV-12 was the most prevalent ESBL, followed by CTX-M-3 and CTX-M-14.
Failure of cefepime therapy in treatment of Klebsiella pneumoniae bacteremia.
The study reports the emergence of reduced susceptibility to cefepime due to the acquisition of the SHV-2 extended-spectrum beta-lactamase in Klebsiella pneumoniae, leading to therapeutic failure.
Clinical and molecular analysis of extended-spectrum {beta}-lactamase-producing enterobacteria in the community setting.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla TEM-24b, bla TEM-21, bla TEM-15, and bla SHV-4, which confer resistance to various beta-lactam antibiotics and other antimicrobials.
Beta-lactam resistance and Enterobacteriaceae, United States.
The study identified bla CMY genes as the primary mechanism of extended-spectrum cephalosporin resistance in non-Typhi Salmonella, including the first report of bla CMY in E. coli O157:H7. It also detected bla SHV in a Salmonella isolate.
Molecular analysis of the simultaneous production of two SHV-type extended-spectrum beta-lactamases in a clinical isolate of Enterobacter cloacae by using single-nucleotide polymorphism genotyping.
The study identifies two SHV-type extended-spectrum beta-lactamases, SHV-7 and SHV-30, produced by a clinical isolate of Enterobacter cloacae. Both enzymes confer resistance to multiple beta-lactam antibiotics.
Molecular analysis of the simultaneous production of two SHV-type extended-spectrum beta-lactamases in a clinical isolate of Enterobacter cloacae by using single-nucleotide polymorphism genotyping.
The study identifies two SHV-type extended-spectrum beta-lactamases, SHV-7 and SHV-30, produced by a clinical isolate of Enterobacter cloacae. Both enzymes confer resistance to multiple beta-lactam antibiotics.
Molecular analysis of the simultaneous production of two SHV-type extended-spectrum beta-lactamases in a clinical isolate of Enterobacter cloacae by using single-nucleotide polymorphism genotyping.
Molecular analysis of the simultaneous production of two SHV-type extended-spectrum beta-lactamases in a clinical isolate of Enterobacter cloacae by using single-nucleotide polymorphism genotyping.
Molecular analysis of the simultaneous production of two SHV-type extended-spectrum beta-lactamases in a clinical isolate of Enterobacter cloacae by using single-nucleotide polymorphism genotyping.
Molecular analysis of the simultaneous production of two SHV-type extended-spectrum beta-lactamases in a clinical isolate of Enterobacter cloacae by using single-nucleotide polymorphism genotyping.
Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla SHV-2a, bla SHV-5, bla SHV-8, bla SHV-11, bla SHV-12, bla TEM-1, bla TEM-24, bla TEM-93, and bla TEM-116, in Klebsiella pneumoniae isolates. These genes confer resistance to cephalosporins, penicillins, and monobactams.
Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla SHV-2a, bla SHV-5, bla SHV-8, bla SHV-11, bla SHV-12, bla TEM-1, bla TEM-24, bla TEM-93, and bla TEM-116, in Klebsiella pneumoniae isolates. These genes confer resistance to cephalosporins, penicillins, and monobactams.
Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla SHV-2a, bla SHV-5, bla SHV-8, bla SHV-11, bla SHV-12, bla TEM-1, bla TEM-24, bla TEM-93, and bla TEM-116, in Klebsiella pneumoniae isolates. These genes confer resistance to cephalosporins, penicillins, and monobactams.
Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla SHV-2a, bla SHV-5, bla SHV-8, bla SHV-11, bla SHV-12, bla TEM-1, bla TEM-24, bla TEM-93, and bla TEM-116, in Klebsiella pneumoniae isolates. These genes confer resistance to cephalosporins, penicillins, and monobactams.
Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla SHV-2a, bla SHV-5, bla SHV-8, bla SHV-11, bla SHV-12, bla TEM-1, bla TEM-24, bla TEM-93, and bla TEM-116, in Klebsiella pneumoniae isolates. These genes confer resistance to cephalosporins, penicillins, and monobactams.
Detection and genotyping of SHV beta-lactamase variants by mass spectrometry after base-specific cleavage of in vitro-generated RNA transcripts.
The study presents a novel method for the detection and genotyping of SHV beta-lactamase variants using mass spectrometry after base-specific cleavage of in vitro-generated RNA transcripts, allowing for the identification of multiple point mutations in a single assay.
Characterisation of a novel extended-spectrum beta-lactamase, SHV-70, from a clinical isolate of Enterobacter cloacae in China.
Characterisation of a novel extended-spectrum beta-lactamase, SHV-70, from a clinical isolate of Enterobacter cloacae in China.
Characterisation of a novel extended-spectrum beta-lactamase, SHV-70, from a clinical isolate of Enterobacter cloacae in China.
Characterisation of a novel extended-spectrum beta-lactamase, SHV-70, from a clinical isolate of Enterobacter cloacae in China.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae, Central African Republic.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla SHV-2a, bla SHV-12, bla CTX-M-15, and bla CTX-M-3, in Enterobacteriaceae isolates from the Central African Republic. These genes conferred resistance to various beta-lactam antibiotics.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae, Central African Republic.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla SHV-2a, bla SHV-12, bla CTX-M-15, and bla CTX-M-3, in Enterobacteriaceae isolates from the Central African Republic. These genes conferred resistance to various beta-lactam antibiotics.
Occurrence of a novel SHV-type enzyme (SHV-55) among isolates of Klebsiella pneumoniae from Portuguese origin in a comparison study for extended-spectrum beta-lactamase-producing evaluation.
Occurrence of a novel SHV-type enzyme (SHV-55) among isolates of Klebsiella pneumoniae from Portuguese origin in a comparison study for extended-spectrum beta-lactamase-producing evaluation.
Occurrence of a novel SHV-type enzyme (SHV-55) among isolates of Klebsiella pneumoniae from Portuguese origin in a comparison study for extended-spectrum beta-lactamase-producing evaluation.
Evaluation of the new VITEK 2 extended-spectrum beta-lactamase (ESBL) test for rapid detection of ESBL production in Enterobacteriaceae isolates.
The study evaluated the VITEK 2 ESBL test for rapid detection of ESBL-producing Enterobacteriaceae isolates, identifying bla TEM, bla SHV, and bla CTX-M genes as major contributors to extended-spectrum beta-lactamase production.
Prevalence of newer beta-lactamases in gram-negative clinical isolates collected in the United States from 2001 to 2002.
The study identified various beta-lactamases including SHV, CTX-M, FOX, CMY, DHA, and KPC, which confer resistance to multiple beta-lactam antibiotics in gram-negative clinical isolates in the United States.
Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands.
The study identifies a novel SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain responsible for a large nosocomial outbreak in the Netherlands. SHV-31 exhibits resistance to extended-spectrum cephalosporins and was functionally validated through cloning and MIC testing.
Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands.
Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands.
Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands.
Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands.
Evaluation of a new selective chromogenic agar medium for detection of extended-spectrum beta-lactamase-producing Enterobacteriaceae.
The study evaluates a new chromogenic agar medium (ESBL-Bx) for detecting extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae. It identifies bla TEM, bla SHV, and bla CTX-M genes as the primary resistance mechanisms.
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
[Genotype of TEM- and SHV-type beta-lactamase producing Klebsiella pneumoniae in Guangzhou area].
Detection of extended-spectrum beta-lactamases by using boronic acid as an AmpC beta-lactamase inhibitor in clinical isolates of Klebsiella spp. and Escherichia coli.
The study evaluates the use of boronic acid as an inhibitor to enhance the detection of extended-spectrum beta-lactamases (ESBLs) in clinical isolates of Klebsiella spp. and Escherichia coli, particularly in cases where ESBLs may be masked by plasmid-mediated AmpC beta-lactamases (pAmpCs).
Molecular cloning and nucleotide sequence of a new plasmid-coded Klebsiella pneumoniae beta-lactamase gene (SHV-2a) responsible for high-level cefotaxime resistance.
Molecular cloning and nucleotide sequence of a new plasmid-coded Klebsiella pneumoniae beta-lactamase gene (SHV-2a) responsible for high-level cefotaxime resistance.
Molecular cloning and nucleotide sequence of a new plasmid-coded Klebsiella pneumoniae beta-lactamase gene (SHV-2a) responsible for high-level cefotaxime resistance.
Nosocomial outbreak due to extended-spectrum-beta-lactamase-producing Enterobacter cloacae in a cardiothoracic intensive care unit.
The study identifies the presence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacter cloacae in a cardiothoracic intensive care unit, highlighting the role of bla SHV, bla TEM, and CTX-M-9 genes in conferring resistance to cephalosporins.
Multiplex Asymmetric PCR-Based Oligonucleotide Microarray for Detection of Drug Resistance Genes Containing Single Mutations in Enterobacteriaceae
The study developed a multiplex asymmetric PCR-based microarray for detecting drug resistance genes containing single mutations in Enterobacteriaceae, focusing on beta-lactamase genes such as bla SHV, bla TEM, bla CTX-M-3, bla CTX-M-9, bla DHA-1, bla CMY-2, bla MOX-1, bla ACC-1, bla FOX-5, and bla MIR-1. It also identified six point mutations in the bla SHV gene.
Zoo animals as reservoirs of gram-negative bacteria harboring integrons and antimicrobial resistance genes.
The study identified various antimicrobial resistance genes in gram-negative bacteria isolated from zoo animals, including bla TEM-1, bla OXY-2, bla SHV-36, bla CTX-M-2, bla CMY-26, qnrB, qnrS, and aac(6')-Ib-cr.
Incidence of class A extended-spectrum beta-lactamases in Champagne-Ardenne (France): a 1 year prospective study.
Incidence of class A extended-spectrum beta-lactamases in Champagne-Ardenne (France): a 1 year prospective study.
Incidence of class A extended-spectrum beta-lactamases in Champagne-Ardenne (France): a 1 year prospective study.
Incidence of class A extended-spectrum beta-lactamases in Champagne-Ardenne (France): a 1 year prospective study.
Impact of feed supplementation with antimicrobial agents on growth performance of broiler chickens, Clostridium perfringens and enterococcus counts, and antibiotic resistance phenotypes and distribution of antimicrobial resistance determinants in Escherichia coli isolates.
The study identified several AMR genes in E. coli isolates from broiler chickens, including blaTEM, blaSHV, aadA, tet(A), tet(B), sulI, sulII, and floR, which conferred resistance to various antibiotics such as amoxicillin, tetracycline, sulfonamides, and chloramphenicol.
High diversity of extended-spectrum beta-lactamases among clinical isolates of Enterobacteriaceae from Portugal.
High diversity of extended-spectrum beta-lactamases among clinical isolates of Enterobacteriaceae from Portugal.
High diversity of extended-spectrum beta-lactamases among clinical isolates of Enterobacteriaceae from Portugal.
Molecular epidemiology of Escherichia coli producing extended-spectrum beta-lactamases isolated in Rome, Italy.
The study identifies blaCTX-M-15 as the predominant ESBL gene in E. coli isolates from Rome, Italy, with 26 out of 28 isolates carrying this gene. Other ESBL genes identified include blaCTX-M-14, blaSHV-12, blaTEM-1, and blaOXA-1.
Selection of SHV Extended-Spectrum-β-Lactamase-Dependent Cefotaxime and Ceftazidime Resistance in Klebsiella pneumoniae Requires a Plasmid-Borne blaSHV Gene
Prevalence of qnr genes among extended-spectrum beta-lactamase-producing enterobacterial isolates in Barcelona, Spain.
Prevalence of qnr genes among extended-spectrum beta-lactamase-producing enterobacterial isolates in Barcelona, Spain.
Prevalence of qnr genes among extended-spectrum beta-lactamase-producing enterobacterial isolates in Barcelona, Spain.
Prevalence of qnr genes among extended-spectrum beta-lactamase-producing enterobacterial isolates in Barcelona, Spain.
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
The study identifies various beta-lactamase genes (bla CMY-2, bla CMY-23, bla SHV-12, bla SHV-30, bla OXA-1, bla OXA-9) and a qnrB2 gene associated with reduced susceptibility to quinolones and extended-spectrum cephalosporins in Salmonella isolates. Additionally, mutations in gyrA and parC genes contribute to quinolone resistance.
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
The study identifies various beta-lactamase genes (bla CMY-2, bla CMY-23, bla SHV-12, bla SHV-30, bla OXA-1, bla OXA-9) and a qnrB2 gene associated with reduced susceptibility to quinolones and extended-spectrum cephalosporins in Salmonella isolates. Additionally, mutations in gyrA and parC genes contribute to quinolone resistance.
Successive emergence of extended-spectrum beta-lactamase-producing and carbapenemase-producing Enterobacter aerogenes isolates in a university hospital.
The study identifies bla TEM-24, bla SHV-12, bla IMP-1, and bla VIM-2 as the primary resistance genes in carbapenem-resistant Enterobacter aerogenes isolates, highlighting the role of beta-lactamases in resistance to various antibiotics.
First outbreak of multidrug-resistant Klebsiella pneumoniae producing both SHV-12-type extended-spectrum beta-lactamase and DHA-1-type AmpC beta-lactamase at a Korean hospital.
The study reports the first outbreak of multidrug-resistant Klebsiella pneumoniae producing both SHV-12-type extended-spectrum beta-lactamase and DHA-1-type AmpC beta-lactamase in Korea.
The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition.
The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition.
The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition.
The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition.
Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil.
The study identifies the novel CTX-M-59 beta-lactamase variant in a multiclonal outbreak of Klebsiella pneumoniae in a Brazilian NICU, along with the established CTX-M-2 and SHV-5 variants.
Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil.
Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil.
Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil.
Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil.
Longitudinal study of antimicrobial resistance among Escherichia coli isolates from integrated multisite cohorts of humans and swine.
The study identified various AMR genes in E. coli isolates from humans and swine, highlighting differences in resistance profiles between the two hosts. Key genes included beta-lactamases (blaCTX-M, blaTEM, blaSHV), aminoglycoside modifying enzymes (aac(6')-Ib, aadA), tetracycline resistance (tet(A)), quinolone resistance (qnrS1), macrolide resistance (erm(B)), and efflux pumps (mexAB-OprM).
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
The study identified various beta-lactamases, including CTX-M-3, CTX-M-15, SHV-2, SHV-5, SHV-12, TEM-19, TEM-48, CMY-12, CMY-15, CMY-38, TEM-30, TEM-32, TEM-37, and SHV-49, which confer resistance to newer beta-lactam antibiotics in Enterobacteriaceae isolates from Polish hospitals.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
The study identified various beta-lactamases, including CTX-M-3, CTX-M-15, SHV-2, SHV-5, SHV-12, TEM-19, TEM-48, CMY-12, CMY-15, CMY-38, TEM-30, TEM-32, TEM-37, and SHV-49, which confer resistance to newer beta-lactam antibiotics in Enterobacteriaceae isolates from Polish hospitals.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
The study identified various beta-lactamases, including CTX-M-3, CTX-M-15, SHV-2, SHV-5, SHV-12, TEM-19, TEM-48, CMY-12, CMY-15, CMY-38, TEM-30, TEM-32, TEM-37, and SHV-49, which confer resistance to newer beta-lactam antibiotics in Enterobacteriaceae isolates from Polish hospitals.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
The study identified various beta-lactamases, including CTX-M-3, CTX-M-15, SHV-2, SHV-5, SHV-12, TEM-19, TEM-48, CMY-12, CMY-15, CMY-38, TEM-30, TEM-32, TEM-37, and SHV-49, which confer resistance to newer beta-lactam antibiotics in Enterobacteriaceae isolates from Polish hospitals.
Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic.
The study identified the high prevalence of bla CTX-M genes in ESBL-producing E. coli and K. pneumoniae isolates in Thailand, highlighting the endemic nature of CTX-M-type ESBLs. It also reported the first detection of CTX-M-3, CTX-M-27, CTX-M-40, SHV-27, SHV-71, and SHV-75 in Thailand.
Characterization of extended-spectrum beta-lactamases and integrons in Escherichia coli isolates in a Spanish hospital.
Characterization of extended-spectrum beta-lactamases and integrons in Escherichia coli isolates in a Spanish hospital.
Characterization of extended-spectrum beta-lactamases and integrons in Escherichia coli isolates in a Spanish hospital.
Characterization of extended-spectrum beta-lactamases and integrons in Escherichia coli isolates in a Spanish hospital.
A novel SHV-type beta-lactamase variant (SHV-89) in clinical isolates in China.
A novel SHV-type beta-lactamase variant (SHV-89) in clinical isolates in China.
A novel SHV-type beta-lactamase variant (SHV-89) in clinical isolates in China.
A novel SHV-type beta-lactamase variant (SHV-89) in clinical isolates in China.
Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Escherichia coli: risk factors for inadequate initial antimicrobial therapy.
The study identifies bla CTX-M, bla SHV, and bla TEM genes as the primary mechanisms of extended-spectrum beta-lactamase (ESBL) production in Escherichia coli causing bloodstream infections, highlighting their role in resistance to various beta-lactam antibiotics.
Genetic characterisation of CTX-M-15-producing Klebsiella pneumoniae and Escherichia coli strains isolated from stem cell transplant patients in Tunisia.
Genetic characterisation of CTX-M-15-producing Klebsiella pneumoniae and Escherichia coli strains isolated from stem cell transplant patients in Tunisia.
Genetic characterisation of CTX-M-15-producing Klebsiella pneumoniae and Escherichia coli strains isolated from stem cell transplant patients in Tunisia.
Genetic characterisation of CTX-M-15-producing Klebsiella pneumoniae and Escherichia coli strains isolated from stem cell transplant patients in Tunisia.
Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae.
The study identifies SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae, which exhibits resistance to ampicillin, amoxicillin, ticarcillin, and piperacillin.
Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae.
Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae.
Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae.
Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae.
Transfer of antimicrobial resistance plasmids from Klebsiella pneumoniae to Escherichia coli in the mouse intestine.
The study demonstrates the transfer of antimicrobial resistance plasmids from Klebsiella pneumoniae to Escherichia coli in the mouse intestine, highlighting the role of antimicrobial treatment in selecting for resistant strains and facilitating gene transfer.
Dominance of blaCTX-M within an Australian extended-spectrum beta-lactamase gene pool.
Dominance of blaCTX-M within an Australian extended-spectrum beta-lactamase gene pool.
Dominance of blaCTX-M within an Australian extended-spectrum beta-lactamase gene pool.
Dominance of blaCTX-M within an Australian extended-spectrum beta-lactamase gene pool.
Novel transferable extended-spectrum beta-lactamase (SHV-6) from Klebsiella pneumoniae conferring selective resistance to ceftazidime.
Novel transferable extended-spectrum beta-lactamase (SHV-6) from Klebsiella pneumoniae conferring selective resistance to ceftazidime.
ESBL genotypes in fluoroquinolone-resistant and fluoroquinolone-susceptible ESBL-producing Escherichia coli urinary isolates in Manitoba.
The study identifies CTX-M-15 as being strongly associated with multidrug resistance (MDR) in E. coli, while CTX-M-14 is linked primarily to fluoroquinolone (FQ) resistance. Other ESBL genotypes such as CTX-M-9, CTX-M-24, SHV, and TEM were also characterized.
Strategic design of an effective beta-lactamase inhibitor: LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone.
LN-1-255 is an effective beta-lactamase inhibitor that enhances the activity of beta-lactam antibiotics against strains producing SHV-1, SHV-2, and other beta-lactamases.
Strategic design of an effective beta-lactamase inhibitor: LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone.
LN-1-255 is an effective beta-lactamase inhibitor that enhances the activity of beta-lactam antibiotics against strains producing SHV-1, SHV-2, and other beta-lactamases.
Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-2, bla CTX-M-5, bla CTX-M-15, bla CTX-M-22, bla CTX-M-28, bla SHV-5, bla SHV-12, bla TEM-1, bla OXA-1, bla OXA-2, bla OXA-5, bla PER-1, bla ACT-1, bla MIR-1, bla CMY-2, bla FOX-1, bla DHA-1, and bla KPC-2, in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates.
Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-2, bla CTX-M-5, bla CTX-M-15, bla CTX-M-22, bla CTX-M-28, bla SHV-5, bla SHV-12, bla TEM-1, bla OXA-1, bla OXA-2, bla OXA-5, bla PER-1, bla ACT-1, bla MIR-1, bla CMY-2, bla FOX-1, bla DHA-1, and bla KPC-2, in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates.
First characterization and emergence of SHV-60 in raw milk of a healthy cow in Japan.
Major enzymatic factors involved in bacterial penicillin resistance in Burkina Faso.
The study identified blaTEM-1 and blaSHV-1 as the primary beta-lactamase genes responsible for penicillin resistance in Escherichia coli and Klebsiella pneumoniae isolates from Burkina Faso.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
The study identifies three novel beta-lactamase genes, blaSHV-48, blaSHV-105, and blaTEM-155, which confer resistance to various beta-lactam antibiotics.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
The study identifies three novel beta-lactamase genes, blaSHV-48, blaSHV-105, and blaTEM-155, which confer resistance to various beta-lactam antibiotics.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
Unreliable extended-spectrum beta-lactamase detection in the presence of plasmid-mediated AmpC in Escherichia coli clinical isolates.
The study highlights the challenges in detecting extended-spectrum beta-lactamase (ESBL) in the presence of plasmid-mediated AmpC (pAmpC) in E. coli clinical isolates, identifying several ESBL genes (blaTEM-1, blaSHV, blaCTX-M) and pAmpC genes (cmrA, FOX-5) that contribute to resistance against various beta-lactam antibiotics.
SHV-28, an extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae in south India.
SHV-28, an extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae in south India.
SHV-28, an extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae in south India.
SHV-28, an extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae in south India.
Ertapenem resistance among extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae isolates.
The study identifies several extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-2, blaCTX-M-10, blaSHV-12, and blaSHV-28, along with the loss of the outer membrane protein OmpK36, as mechanisms contributing to ertapenem resistance in Klebsiella pneumoniae isolates.
Ertapenem resistance among extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae isolates.
The study identifies several extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-2, blaCTX-M-10, blaSHV-12, and blaSHV-28, along with the loss of the outer membrane protein OmpK36, as mechanisms contributing to ertapenem resistance in Klebsiella pneumoniae isolates.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Portugal.
Prevalence and molecular characterization of ampicillin-resistant Enterobacteriaceae isolated from traditional Egyptian Domiati cheese.
Prevalence and molecular characterization of ampicillin-resistant Enterobacteriaceae isolated from traditional Egyptian Domiati cheese.
Prevalence and molecular characterization of ampicillin-resistant Enterobacteriaceae isolated from traditional Egyptian Domiati cheese.
Prevalence and molecular characterization of ampicillin-resistant Enterobacteriaceae isolated from traditional Egyptian Domiati cheese.
Prevalence and molecular characterization of ampicillin-resistant Enterobacteriaceae isolated from traditional Egyptian Domiati cheese.
Prevalence and molecular characterization of ampicillin-resistant Enterobacteriaceae isolated from traditional Egyptian Domiati cheese.
Prevalence and molecular characterization of ampicillin-resistant Enterobacteriaceae isolated from traditional Egyptian Domiati cheese.
Antimicrobial resistance genes in Escherichia coli isolates recovered from a commercial beef processing plant
The study identified various antimicrobial resistance genes in E. coli isolates from a commercial beef processing plant, including beta-lactamase genes (blaCMY, blaSHV, blaTEM), tetracycline resistance genes (tetA, tetB, tetC), sulfonamide resistance genes (sul1, sul2), and aminoglycoside resistance genes (strA, strB).
Characterization of multidrug resistant ESBL-producing Escherichia coli isolates from hospitals in Malaysia.
The study identified several ESBL-encoding genes including blaTEM, blaSHV, blaCTX-M, and blaOXA in multidrug-resistant E. coli isolates from Malaysian hospitals. These genes were found to confer resistance to various beta-lactam antibiotics.
Ceftazidime-resistant Salmonella enterica, Morocco.
The study reports the presence of ceftazidime-resistant Salmonella enterica isolates carrying the blaSHV-12 gene, which confers resistance to extended-spectrum cephalosporins.
Detection of CTX-M-Type Extended-Spectrum Beta-Lactamase (ESBLs) by Testing with MicroScan Overnight and ESBL Confirmation Panels
The study evaluated the effectiveness of various methods in detecting CTX-M-type extended-spectrum beta-lactamases (ESBLs) in Enterobacteriaceae isolates, identifying several CTX-M variants including CTX-M15, CTX-M16, CTX-M14, CTX-M8, and others, along with SHV and TEM ESBLs.
Detection of CTX-M-Type Extended-Spectrum Beta-Lactamase (ESBLs) by Testing with MicroScan Overnight and ESBL Confirmation Panels
The study evaluated the effectiveness of various methods in detecting CTX-M-type extended-spectrum beta-lactamases (ESBLs) in Enterobacteriaceae isolates, identifying several CTX-M variants including CTX-M15, CTX-M16, CTX-M14, CTX-M8, and others, along with SHV and TEM ESBLs.
Updated functional classification of beta-lactamases.
The paper updates the functional classification of beta-lactamases, detailing their substrate preferences, inhibitor profiles, and clinical relevance. It highlights the diversity and evolution of these enzymes, emphasizing their role in antibiotic resistance.
Integrated detection of extended-spectrum-beta-lactam resistance by DNA microarray-based genotyping of TEM, SHV, and CTX-M genes.
The study presents a DNA microarray for the rapid identification of extended-spectrum beta-lactamase (ESBL) genes, including TEM, SHV, and CTX-M, in Enterobacteriaceae. The microarray successfully identified various ESBL variants, with CTX-M-15 and SHV-12 being the most prevalent. The method demonstrated high accuracy and reliability in detecting ESBL-producing isolates.
Integrated detection of extended-spectrum-beta-lactam resistance by DNA microarray-based genotyping of TEM, SHV, and CTX-M genes.
The study presents a DNA microarray for the rapid identification of extended-spectrum beta-lactamase (ESBL) genes, including TEM, SHV, and CTX-M, in Enterobacteriaceae. The microarray successfully identified various ESBL variants, with CTX-M-15 and SHV-12 being the most prevalent. The method demonstrated high accuracy and reliability in detecting ESBL-producing isolates.
Integrated detection of extended-spectrum-beta-lactam resistance by DNA microarray-based genotyping of TEM, SHV, and CTX-M genes.
The study presents a DNA microarray for the rapid identification of extended-spectrum beta-lactamase (ESBL) genes, including TEM, SHV, and CTX-M, in Enterobacteriaceae. The microarray successfully identified various ESBL variants, with CTX-M-15 and SHV-12 being the most prevalent. The method demonstrated high accuracy and reliability in detecting ESBL-producing isolates.
Characterization of ESBL (SHV-12) producing clinical isolate of Enterobacter aerogenes from a tertiary care hospital in Nigeria.
The study reports the first identification of the SHV-12 extended-spectrum beta-lactamase in Nigeria, associated with an Enterobacter aerogenes isolate. The gene was cloned and characterized, demonstrating resistance to beta-lactam antibiotics.
Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain.
Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain.
Citrobacter spp. simultaneously harboring blaCTX-M, blaTEM, blaSHV, blaampC, and insertion sequences IS26 and orf513: an evolutionary phenomenon of recent concern for antibiotic resistance.
The study identifies the presence of multiple beta-lactamase genes (blaCTX-M, blaTEM, blaSHV, and blaampC) in Citrobacter spp., highlighting their role in antibiotic resistance. It also reports the association of IS26 and orf513 with these resistance genes, indicating a complex evolutionary mechanism.
Screening extended-spectrum beta-lactamase production in Enterobacter cloacae and Serratia marcescens using antibiogram-based methods.
The study identifies bla SHV-12, bla CTX-M-3, and bla CTX-M-14 as extended-spectrum beta-lactamase genes in Enterobacter cloacae and Serratia marcescens, which confer resistance to various cephalosporins.
Enumeration and characterization of antimicrobial-resistant Escherichia coli bacteria in effluent from municipal, hospital, and secondary treatment facility sources.
The study identifies several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-28, bla CTX-M-3, bla CTX-M-61, bla TEM, and bla SHV, which confer resistance to various beta-lactam antibiotics in Escherichia coli isolates from effluent samples.
Evaluation of a DNA microarray, the check-points ESBL/KPC array, for rapid detection of TEM, SHV, and CTX-M extended-spectrum beta-lactamases and KPC carbapenemases.
The Check-Points ESBL/KPC array effectively detects TEM, SHV, CTX-M, and KPC beta-lactamase genes, offering rapid and accurate identification of extended-spectrum beta-lactamases and carbapenemases in clinical isolates.
Identification of SHV-type and CTX-M-12 extended-spectrum beta-lactamases (ESBLs) in multiresistant Enterobacteriaceae from Colombian Caribbean hospitals.
Identification of SHV-type and CTX-M-12 extended-spectrum beta-lactamases (ESBLs) in multiresistant Enterobacteriaceae from Colombian Caribbean hospitals.
Identification of SHV-type and CTX-M-12 extended-spectrum beta-lactamases (ESBLs) in multiresistant Enterobacteriaceae from Colombian Caribbean hospitals.
Molecular characteristics of extended spectrum beta-lactamases in Escherichia coli and Klebsiella pneumoniae and the prevalence of qnr in Extended spectrum beta-lactamase isolates in a tertiary care hospital in Korea.
The study identified CTX-M15 as the most prevalent ESBL in E. coli and K. pneumoniae, along with CTX-M14 in E. coli and CTX-M15 and SHV-12 in K. pneumoniae. High prevalence of qnrB4 and qnrS1 was found in ESBL-producing K. pneumoniae.
Worldwide diversity of Klebsiella pneumoniae that produce beta-lactamase blaKPC-2 gene.
The study identifies various beta-lactamase genes including blaKPC-2, blaSHV-1, blaSHV-11, blaOKP-A/B, blaTEM-1, blaCTX-M-2, blaCTX-M-12, blaCTX-M-15, and blaOXA-9 in K. pneumoniae isolates from multiple countries, highlighting the diversity and global spread of these resistance genes.
Worldwide diversity of Klebsiella pneumoniae that produce beta-lactamase blaKPC-2 gene.
The study identifies various beta-lactamase genes including blaKPC-2, blaSHV-1, blaSHV-11, blaOKP-A/B, blaTEM-1, blaCTX-M-2, blaCTX-M-12, blaCTX-M-15, and blaOXA-9 in K. pneumoniae isolates from multiple countries, highlighting the diversity and global spread of these resistance genes.
Outbreak of nosocomial infections due to Klebsiella pneumoniae producing SHV-4 beta-lactamase.
Outbreak of nosocomial infections due to Klebsiella pneumoniae producing SHV-4 beta-lactamase.
Outbreak of nosocomial infections due to Klebsiella pneumoniae producing SHV-4 beta-lactamase.
Outbreak of nosocomial infections due to Klebsiella pneumoniae producing SHV-4 beta-lactamase.
Outbreak of nosocomial infections due to Klebsiella pneumoniae producing SHV-4 beta-lactamase.
Nucleotide sequence of the SHV-5 beta-lactamase gene of a Klebsiella pneumoniae plasmid.
Nucleotide sequence of the SHV-5 beta-lactamase gene of a Klebsiella pneumoniae plasmid.
Nucleotide sequence of the SHV-5 beta-lactamase gene of a Klebsiella pneumoniae plasmid.
Nucleotide sequence of the SHV-5 beta-lactamase gene of a Klebsiella pneumoniae plasmid.
Diversity of clavulanic acid-inhibited extended-spectrum beta-lactamases in Aeromonas spp. from the Seine River, Paris, France.
The study identified various clavulanic acid-inhibited extended-spectrum beta-lactamases (ESBLs) in Aeromonas spp. from the Seine River, including blaVEB-1a, blaSHV-12, blaPER-1, blaPER-6, blaTLA-2, and blaGES-7, highlighting the diversity of ESBLs in aquatic environments.
Chromosome-encoded AmpC and CTX-M extended-spectrum beta-lactamases in clinical isolates of Proteus mirabilis from Korea.
The study identifies several extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase genes, including bla CTX-M-14a, bla CTX-M-90, bla CTX-M-15, bla CTX-M-12, bla CTX-M-2, bla CTX-M-14b, bla TEM-52, bla SHV-12, bla CMY-2, and bla DHA-1, in clinical isolates of Proteus mirabilis from Korea. These genes were found to be responsible for resistance to various β-lactam antibiotics.
Enzymatic analysis of the effect of naturally occurring Leu138Pro mutation identified in SHV beta-lactamase on hydrolysis of penicillin and ampicillin.
The study identifies the Leu138Pro mutation in the SHV beta-lactamase gene, which reduces the hydrolysis activity of penicillin and ampicillin.
Enzymatic analysis of the effect of naturally occurring Leu138Pro mutation identified in SHV beta-lactamase on hydrolysis of penicillin and ampicillin.
The study identifies the Leu138Pro mutation in the SHV beta-lactamase gene, which reduces the hydrolysis activity of penicillin and ampicillin.
Antimicrobial Susceptibility and Multiplex PCR Screening of AmpC Genes From Isolates of Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens.
The study identified ampC genes of DHA, EBC, and CIT types in Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens isolates, along with TEM, CTX-M-3-like, and SHV genes, demonstrating their roles in conferring resistance to various beta-lactam antibiotics.
Clonal spread of antimicrobial-resistant Escherichia coli isolates among pups in two kennels.
The study identified SHV-12 ESBL-producing E. coli isolates in pups from two kennels, highlighting the clonal spread of multidrug-resistant and ESBL-producing isolates among kennel pups.
Prevalence of the bla (SHV) gene in Klebsiella pneumoniae isolates obtained from hospital and community infections and from the microbiota of healthy individuals in Recife, Brazil.
Prevalence of the bla (SHV) gene in Klebsiella pneumoniae isolates obtained from hospital and community infections and from the microbiota of healthy individuals in Recife, Brazil.
Prevalence of the bla (SHV) gene in Klebsiella pneumoniae isolates obtained from hospital and community infections and from the microbiota of healthy individuals in Recife, Brazil.
Molecular docking analysis of new generation cephalosporins interactions with recently known SHV-variants.
Molecular docking analysis of new generation cephalosporins interactions with recently known SHV-variants.
Molecular docking analysis of new generation cephalosporins interactions with recently known SHV-variants.
Role of SHV β-lactamase variants in resistance of clinical Klebsiella pneumoniae strains to β-lactams in an Algerian hospital.
Role of SHV β-lactamase variants in resistance of clinical Klebsiella pneumoniae strains to β-lactams in an Algerian hospital.
Role of SHV β-lactamase variants in resistance of clinical Klebsiella pneumoniae strains to β-lactams in an Algerian hospital.
Role of SHV β-lactamase variants in resistance of clinical Klebsiella pneumoniae strains to β-lactams in an Algerian hospital.
Role of SHV β-lactamase variants in resistance of clinical Klebsiella pneumoniae strains to β-lactams in an Algerian hospital.
Role of SHV β-lactamase variants in resistance of clinical Klebsiella pneumoniae strains to β-lactams in an Algerian hospital.
Role of SHV β-lactamase variants in resistance of clinical Klebsiella pneumoniae strains to β-lactams in an Algerian hospital.
Role of SHV β-lactamase variants in resistance of clinical Klebsiella pneumoniae strains to β-lactams in an Algerian hospital.
Role of SHV β-lactamase variants in resistance of clinical Klebsiella pneumoniae strains to β-lactams in an Algerian hospital.
Role of SHV β-lactamase variants in resistance of clinical Klebsiella pneumoniae strains to β-lactams in an Algerian hospital.
Role of SHV β-lactamase variants in resistance of clinical Klebsiella pneumoniae strains to β-lactams in an Algerian hospital.
Role of SHV β-lactamase variants in resistance of clinical Klebsiella pneumoniae strains to β-lactams in an Algerian hospital.
Emergence of NDM-1-producing Enterobacteriaceae in Belgium.
The study reports the emergence of NDM-1-producing Enterobacteriaceae in Belgium, highlighting the presence of multiple resistance mechanisms including blaNDM-1, qnrA6, qnrB1, qnrB2, and various beta-lactamases, rRNA methylases, and quinolone resistance genes.
Molecular characterization of VIM-producing Klebsiella pneumoniae from Scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance.
The study characterizes VIM-producing Klebsiella pneumoniae isolates from Scandinavia, identifying various resistance genes including bla(VIM-1), bla(VIM-26), ctx-m-3, shv-5, shv-12, armA, and qnrS, which contribute to multidrug resistance.
Susceptibility of Klebsiella pneumoniae isolates from intra-abdominal infections and molecular characterization of ertapenem-resistant isolates.
The study identified KPC-2, KPC-3, KPC-11, OXA-48, SHV-12, and CTX-M-15 as the primary resistance mechanisms in ertapenem-resistant Klebsiella pneumoniae isolates.
bla(CTX-M), bla(TEM), and bla(SHV) in Enterobacteriaceae from North-Indian tertiary hospital: high occurrence of combination genes.
The study identified the high occurrence of bla(CTX-M), bla(TEM), and bla(SHV) genes in Enterobacteriaceae from a North-Indian tertiary hospital, highlighting the widespread dissemination of these genes and their combination in clinical isolates.
Detection of betalactamase producing bacterial genes and their clinical features.
The study identified TEM and SHV beta-lactamase genes as the most common drug resistance genes in E. coli and Klebsiella spp. isolates, with TEM being present in 50% of the isolates and SHV in 11%. Coexistence of TEM and SHV was found in 11% of the isolates.
Detection of clinically important beta-lactamases in commensal Escherichia coli of human and swine origin in western China.
The study identified various beta-lactamase genes, including bla CTX-M-1 group variants and bla SHV, as prevalent in commensal E. coli from humans and swine in western China. Additionally, bla CMY-2 was commonly found in both human and swine isolates, while bla KPC was detected in some human isolates.
Detection of clinically important beta-lactamases in commensal Escherichia coli of human and swine origin in western China.
The study identified various beta-lactamase genes, including bla CTX-M-1 group variants and bla SHV, as prevalent in commensal E. coli from humans and swine in western China. Additionally, bla CMY-2 was commonly found in both human and swine isolates, while bla KPC was detected in some human isolates.
Detection of clinically important beta-lactamases in commensal Escherichia coli of human and swine origin in western China.
The study identified various beta-lactamase genes, including bla CTX-M-1 group variants and bla SHV, as prevalent in commensal E. coli from humans and swine in western China. Additionally, bla CMY-2 was commonly found in both human and swine isolates, while bla KPC was detected in some human isolates.
Detection of clinically important beta-lactamases in commensal Escherichia coli of human and swine origin in western China.
The study identified various beta-lactamase genes, including bla CTX-M-1 group variants and bla SHV, as prevalent in commensal E. coli from humans and swine in western China. Additionally, bla CMY-2 was commonly found in both human and swine isolates, while bla KPC was detected in some human isolates.
Detection of clinically important beta-lactamases in commensal Escherichia coli of human and swine origin in western China.
The study identified various beta-lactamase genes, including bla CTX-M-1 group variants and bla SHV, as prevalent in commensal E. coli from humans and swine in western China. Additionally, bla CMY-2 was commonly found in both human and swine isolates, while bla KPC was detected in some human isolates.
Detection of clinically important β-lactamases in commensal Escherichia coli of human and swine origin in western China.
Detection of clinically important β-lactamases in commensal Escherichia coli of human and swine origin in western China.
Detection of clinically important β-lactamases in commensal Escherichia coli of human and swine origin in western China.
Phylogenetic groups and cephalosporin resistance genes of Escherichia coli from diseased food-producing animals in Japan.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-2, bla CTX-M-25, bla CTX-M-15, and bla SHV-2, as well as the AmpC beta-lactamase gene bla CMY-2, in Escherichia coli isolates from diseased food-producing animals in Japan.
Nosocomial outbreak of VIM-1-producing Klebsiella pneumoniae isolates of multilocus sequence type 15: molecular basis, clinical risk factors, and outcome.
Nosocomial outbreak of VIM-1-producing Klebsiella pneumoniae isolates of multilocus sequence type 15: molecular basis, clinical risk factors, and outcome.
Nosocomial outbreak of VIM-1-producing Klebsiella pneumoniae isolates of multilocus sequence type 15: molecular basis, clinical risk factors, and outcome.
Comparative study on occurrence of class A and class C beta-lactamase genes and their co-occurrence in Indian Enterobacteriaceae during years 2009 and 2010.
The study identified the occurrence and co-occurrence of class A (bla CTX-M, bla SHV, bla TEM) and class C (bla ampC) beta-lactamase genes in Indian Enterobacteriaceae isolates, highlighting a decrease in the co-existence of bla ESBLs with bla ampC from 2009 to 2010.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Characterization of the inhibitor-resistant SHV beta-lactamase SHV-107 in a clinical Klebsiella pneumoniae strain coproducing GES-7 enzyme.
The study characterizes the inhibitor-resistant SHV beta-lactamase SHV-107, which differs from SHV-1 by the amino acid substitutions Leu35Gln and Thr235Ala, and shows that this enzyme confers resistance to penicillins and exhibits reduced susceptibility to clavulanate.
Characterization of the inhibitor-resistant SHV β-lactamase SHV-107 in a clinical Klebsiella pneumoniae strain coproducing GES-7 enzyme.
Clinical and Microbiologic Characteristics of Cephalosporin-Resistant Escherichia coli at Three Centers in the United States.
The study identified CTX-M-15 as the most common ESBL in cephalosporin-resistant E. coli, followed by CMY-2, SHV, TEM, and KPC beta-lactamases. These genes confer resistance to various beta-lactam antibiotics.
Mechanisms of resistance and clinical relevance of resistance to β-lactams, glycopeptides, and fluoroquinolones.
The paper discusses the mechanisms of resistance to β-lactams, glycopeptides, and fluoroquinolones, highlighting the role of beta-lactamases such as TEM, SHV, CTX-M, KPC, VIM, and NDM, glycopeptide resistance operons like vanA and vanB, and other resistance genes such as ermB, mecA, qnrA, and aac(6')-Ib.
Using nucleic acid microarrays to perform molecular epidemiology and detect novel beta-lactamases: a snapshot of extended-spectrum beta-lactamases throughout the world.
The study identifies two novel beta-lactamase variants, bla SHV-129 and bla KPC-11, in clinical isolates. These genes confer resistance to various β-lactam antibiotics.
Using nucleic acid microarrays to perform molecular epidemiology and detect novel β-lactamases: a snapshot of extended-spectrum β-lactamases throughout the world.
Using nucleic acid microarrays to perform molecular epidemiology and detect novel β-lactamases: a snapshot of extended-spectrum β-lactamases throughout the world.
Using nucleic acid microarrays to perform molecular epidemiology and detect novel β-lactamases: a snapshot of extended-spectrum β-lactamases throughout the world.
Using nucleic acid microarrays to perform molecular epidemiology and detect novel β-lactamases: a snapshot of extended-spectrum β-lactamases throughout the world.
Incidence of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in patients with urinary tract infection.
The study identified blaSHV, blaTEM, and blaCTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) production in Klebsiella pneumoniae isolates from urinary tract infections in Iran.
Occurrence and characteristics of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae in food producing animals, minced meat and raw milk.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including CTX-M-1, CTX-M-14, CTX-M-15, CTX-M-117, CTX-M-186, SHV-12, TEM-1, and TEM-52, in Enterobacteriaceae isolated from food-producing animals, minced meat, and raw milk in Switzerland.
Characterization of extended-spectrum beta-lactamase genes found among Escherichia coli isolates from duck and environmental samples obtained on a duck farm.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-105, bla CTX-M-27, bla CTX-M-55, bla CTX-M-24e, and others, in Escherichia coli isolates from ducks and environmental samples. These genes confer resistance to various β-lactam antibiotics and other antimicrobials.
Predominant characteristics of CTX-M-producing Klebsiella pneumoniae isolates from patients with lower respiratory tract infection in multiple medical centers in China.
Predominant characteristics of CTX-M-producing Klebsiella pneumoniae isolates from patients with lower respiratory tract infection in multiple medical centers in China.
Predominant characteristics of CTX-M-producing Klebsiella pneumoniae isolates from patients with lower respiratory tract infection in multiple medical centers in China.
Predominant characteristics of CTX-M-producing Klebsiella pneumoniae isolates from patients with lower respiratory tract infection in multiple medical centers in China.
Current epidemiology and growing resistance of gram-negative pathogens.
The paper highlights the emergence and spread of multidrug-resistant Gram-negative pathogens, focusing on extended-spectrum beta-lactamases (ESBLs) such as CTX-M-15 and CTX-M-14, carbapenemases like KPC-2, VIM-2, and IMP-6, and aminoglycoside-modifying enzymes such as aac(6')-Ib-cr and armA. It emphasizes the global dissemination of these resistance mechanisms and their impact on treatment options.
Characteristics of plasmids in multi-drug-resistant Enterobacteriaceae isolated during prospective surveillance of a newly opened hospital in Iraq.
The study identified various plasmid-borne antimicrobial resistance genes in multi-drug-resistant Enterobacteriaceae isolates from a newly opened hospital in Iraq, including aminoglycoside, beta-lactam, sulfamethoxazole/trime-thoprim, tetracycline, and chloramphenicol resistance genes.
Substitutions at position 105 in SHV family beta-lactamases decrease catalytic efficiency and cause inhibitor resistance.
Substitutions at position 105 in SHV family beta-lactamases decrease catalytic efficiency and cause inhibitor resistance.
Increased frequency of integrons and beta-lactamase-coding genes among extraintestinal Escherichia coli isolated with a 7-year interval.
The study identified an increase in the frequency of integrons and beta-lactamase-coding genes, particularly bla CTX-M-1, bla CTX-M-3, bla CTX-M-15, bla CTX-M-55, bla TEM-1, bla OXA-1, bla SHV-1, bla SHV-12, bla CMY-15, and bla DHA, in extraintestinal Escherichia coli strains isolated over a 7-year period.
Increased frequency of integrons and beta-lactamase-coding genes among extraintestinal Escherichia coli isolated with a 7-year interval.
The study identified an increase in the frequency of integrons and beta-lactamase-coding genes, particularly bla CTX-M-1, bla CTX-M-3, bla CTX-M-15, bla CTX-M-55, bla TEM-1, bla OXA-1, bla SHV-1, bla SHV-12, bla CMY-15, and bla DHA, in extraintestinal Escherichia coli strains isolated over a 7-year period.
Extended spectrum beta-lactamase-producing Enterobacteriaceae in international travelers and non-travelers in New York City.
The study identified CTX-M-14 and CTX-M-15 beta-lactamase genes in ESBL-producing E. coli isolates from international travelers in New York City, indicating the importation of these resistance genes through travel.
Population distribution of Beta-lactamase conferring resistance to third-generation cephalosporins in human clinical Enterobacteriaceae in the Netherlands.
The study identifies bla CTX-M-15 as the most prevalent ESBL gene in third-generation cephalosporin-resistant Enterobacteriaceae in the Netherlands, along with various other ESBL and AmpC genes such as bla CTX-M-1, bla CTX-M-14, bla SHV-12, bla TEM-52, and bla CMY-2. Mutations in the promoter region of the chromosomal ampC gene were also found to contribute to resistance.
Prevalence and Molecular Characterization of Plasmid-mediated Extended-Spectrum β-Lactamase Genes (balaTEM, blaCTX and blASHV) Among Urinary Escherichia coli Clinical Isolates in Mashhad, Iran.
The study identified the prevalence of plasmid-mediated extended-spectrum beta-lactamase (ESBL) genes blaCTX, blaTEM, and blaSHV among urinary Escherichia coli isolates in Mashhad, Iran. blaCTX was the most prevalent gene, followed by blaTEM and blaSHV.
Diagnosis by real-time polymerase chain reaction of pathogens and antimicrobial resistance genes in bone marrow transplant patients with bloodstream infections.
The study identified mecA, vanA, blaSHV, and blaCTX-M genes in bone marrow transplant patients with bloodstream infections using real-time PCR.
Molecular epidemiology of extended-spectrum β-lactamase-, AmpC β-lactamase- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolated from Canadian hospitals over a 5 year period: CANWARD 2007-11.
Molecular epidemiology of extended-spectrum β-lactamase-, AmpC β-lactamase- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolated from Canadian hospitals over a 5 year period: CANWARD 2007-11.
Molecular epidemiology of extended-spectrum β-lactamase-, AmpC β-lactamase- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolated from Canadian hospitals over a 5 year period: CANWARD 2007-11.
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010).
Molecular characterization of multidrug-resistant extended-spectrum beta-lactamase-producing Enterobacteriaceae isolated in Antananarivo, Madagascar.
The study identified bla CTX-M-15 and bla SHV-12 as the predominant ESBL genes in multidrug-resistant Enterobacteriaceae isolates in Antananarivo, along with other resistance genes such as aac(6')-Ib, tetA, sul1, sul2, qnrA, qnrB, and catB-3.
Molecular characterization and drug resistance of Escherichia coli strains isolated from urine from long-term care facility residents in Cracow, Poland.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-3, bla TEM-1, and bla SHV-12, in Escherichia coli isolates from long-term care facility residents in Poland.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
The study identified various AMR genes and mutations in E. coli and K. pneumoniae isolates, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-15), aminoglycoside-modifying enzymes (aac(6')-Ib-cr, aadA1a, aadA4, aadA5, aph(6')-Id, aph(3')-Ia), and quinolone resistance mutations (gyrA S83L/D87N, parC S80I/E84V). These genes and mutations were validated through whole-genome sequencing and phenotypic testing.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
The study identified various AMR genes and mutations in E. coli and K. pneumoniae isolates, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-15), aminoglycoside-modifying enzymes (aac(6')-Ib-cr, aadA1a, aadA4, aadA5, aph(6')-Id, aph(3')-Ia), and quinolone resistance mutations (gyrA S83L/D87N, parC S80I/E84V). These genes and mutations were validated through whole-genome sequencing and phenotypic testing.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
The study identified various AMR genes and mutations in E. coli and K. pneumoniae isolates, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-15), aminoglycoside-modifying enzymes (aac(6')-Ib-cr, aadA1a, aadA4, aadA5, aph(6')-Id, aph(3')-Ia), and quinolone resistance mutations (gyrA S83L/D87N, parC S80I/E84V). These genes and mutations were validated through whole-genome sequencing and phenotypic testing.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
The study identified various AMR genes and mutations in E. coli and K. pneumoniae isolates, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-15), aminoglycoside-modifying enzymes (aac(6')-Ib-cr, aadA1a, aadA4, aadA5, aph(6')-Id, aph(3')-Ia), and quinolone resistance mutations (gyrA S83L/D87N, parC S80I/E84V). These genes and mutations were validated through whole-genome sequencing and phenotypic testing.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
The study identified various AMR genes and mutations in E. coli and K. pneumoniae isolates, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-15), aminoglycoside-modifying enzymes (aac(6')-Ib-cr, aadA1a, aadA4, aadA5, aph(6')-Id, aph(3')-Ia), and quinolone resistance mutations (gyrA S83L/D87N, parC S80I/E84V). These genes and mutations were validated through whole-genome sequencing and phenotypic testing.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
The study identified various AMR genes and mutations in E. coli and K. pneumoniae isolates, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-15), aminoglycoside-modifying enzymes (aac(6')-Ib-cr, aadA1a, aadA4, aadA5, aph(6')-Id, aph(3')-Ia), and quinolone resistance mutations (gyrA S83L/D87N, parC S80I/E84V). These genes and mutations were validated through whole-genome sequencing and phenotypic testing.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
The study identified various AMR genes and mutations in E. coli and K. pneumoniae isolates, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-15), aminoglycoside-modifying enzymes (aac(6')-Ib-cr, aadA1a, aadA4, aadA5, aph(6')-Id, aph(3')-Ia), and quinolone resistance mutations (gyrA S83L/D87N, parC S80I/E84V). These genes and mutations were validated through whole-genome sequencing and phenotypic testing.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
The study identified various AMR genes and mutations in E. coli and K. pneumoniae isolates, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-15), aminoglycoside-modifying enzymes (aac(6')-Ib-cr, aadA1a, aadA4, aadA5, aph(6')-Id, aph(3')-Ia), and quinolone resistance mutations (gyrA S83L/D87N, parC S80I/E84V). These genes and mutations were validated through whole-genome sequencing and phenotypic testing.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
beta-lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula.
The study identifies various beta-lactamase genes, including CTX-M-15, CTX-M-14, CTX-M-9, SHV-12, SHV-5, TEM-1, VEB-1, GES-1, GES-5, GES-11, PER-1, OXA-48, NDM-1, VIM-2, OXA-23, OXA-40, OXA-58, and OXA-181, which confer resistance to β-lactam antibiotics in Gram-negative pathogens from the Arabian Peninsula.
beta-lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula.
The study identifies various beta-lactamase genes, including CTX-M-15, CTX-M-14, CTX-M-9, SHV-12, SHV-5, TEM-1, VEB-1, GES-1, GES-5, GES-11, PER-1, OXA-48, NDM-1, VIM-2, OXA-23, OXA-40, OXA-58, and OXA-181, which confer resistance to β-lactam antibiotics in Gram-negative pathogens from the Arabian Peninsula.
A simple multiplex PCR for assessing prevalence of extended-spectrum β-lactamases producing Klebsiella pneumoniae in Intensive Care Units of a referral hospital in Shiraz, Iran.
The study identified the prevalence of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae in ICU patients, highlighting the significance of bla_TEM, bla_SHV, and bla_CTX-M genes in conferring resistance to ampicillin.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
Detection of Escherichia coli and associated β-lactamases genes from diabetic foot ulcers by multiplex PCR and molecular modeling and docking of SHV-1, TEM-1, and OXA-1 β-lactamases with clindamycin and piperacillin-tazobactam.
The study identified bla TEM-1, bla SHV-1, bla OXA-1, and bla CTX-M-15 genes in E. coli isolates from diabetic foot ulcers, which confer resistance to multiple beta-lactam antibiotics.
Detection of new SHV-12, SHV-5 and SHV-2a variants of extended spectrum beta-lactamase in Klebsiella pneumoniae in Egypt.
The study identified SHV-12, SHV-5, and SHV-2a variants as prevalent extended-spectrum beta-lactamases in K. pneumoniae isolates in Egypt, contributing to resistance against ceftazidime and cefotaxime.
Detection of new SHV-12, SHV-5 and SHV-2a variants of extended spectrum beta-lactamase in Klebsiella pneumoniae in Egypt.
The study identified SHV-12, SHV-5, and SHV-2a variants as prevalent extended-spectrum beta-lactamases in K. pneumoniae isolates in Egypt, contributing to resistance against ceftazidime and cefotaxime.
Detection of new SHV-12, SHV-5 and SHV-2a variants of extended spectrum beta-lactamase in Klebsiella pneumoniae in Egypt.
The study identified SHV-12, SHV-5, and SHV-2a variants as prevalent extended-spectrum beta-lactamases in K. pneumoniae isolates in Egypt, contributing to resistance against ceftazidime and cefotaxime.
Extended-spectrum beta-lactamase-producing enterobacteriaceae among travelers from the Netherlands.
The study identified CTX-M-15-like, CTX-M-1, CTX-M-3, CTX-M-32, CTX-M-9, SHV-ESBL, CMY-2, and ACT/MIR beta-lactamases as the primary mechanisms of extended-spectrum beta-lactamase (ESBL) resistance in Enterobacteriaceae among travelers from the Netherlands.
Horizontol dissemination of TEM- and SHV-typr beta-lactamase genes-carrying resistance plasmids amongst clonical isolates of Enterobacteriaceae.
The study identifies the horizontal dissemination of TEM- and SHV-type beta-lactamase genes carried by resistance plasmids among clinical isolates of Enterobacteriaceae, highlighting the role of conjugative plasmids in the spread of multidrug resistance.
Extended-spectrum beta-lactamase-producing bacteria isolated from hematologic patients in Manaus, State of Amazonas, Brazil.
The study identified ESBL-producing bacteria carrying bla TEM, bla SHV, bla CTX-M, and bla OXA genes, which confer resistance to various beta-lactam antibiotics in hematologic patients in Manaus, Brazil.
Phenotypic and Genotypic Methods for Detection of Extended Spectrum β Lactamase Producing Escherichia coli and Klebsiella pneumoniae Isolated from Ventilator Associated Pneumonia.
The study identified blaCTX-M, blaSHV, and blaTEM genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) production in Escherichia coli and Klebsiella pneumoniae isolates from ventilator-associated pneumonia cases.
Occurrence and distribution of antibiotic-resistant bacteria and transfer of resistance genes in Lake Taihu.
The study identified various beta-lactamase genes (blaTEM, blaSHV, blaCTXM, blaOXA-1) and the intI integron gene in antibiotic-resistant bacteria from Lake Taihu, highlighting the prevalence of ampicillin resistance and the role of horizontal gene transfer in the dissemination of resistance.
Detection and molecular characterization of Escherichia coli CTX-M-15 and Klebsiella pneumoniae SHV-12 beta-lactamases from bovine mastitis isolates in the United Kingdom.
The study identified the presence of CTX-M-15 and SHV-12 beta-lactamases in Escherichia coli and Klebsiella pneumoniae subsp. pneumoniae isolates from bovine mastitis in the United Kingdom, highlighting the role of these enzymes in conferring resistance to various β-lactam antibiotics.
Single or in combination antimicrobial resistance mechanisms of Klebsiella pneumoniae contribute to varied susceptibility to different carbapenems.
The study identified that blaCTX-M-15, blaSHV-12, blaDHA-1, ampR, blaKPC-2, and blaNDM-1 are responsible for carbapenem resistance in Klebsiella pneumoniae. The loss of porins OmpK35 and OmpK36 combined with these genes contributed to resistance against various carbapenems.
Identification of a novel SHV-β-lactamase variant (SHV-144) in a Malaysian multidrug-resistant Klebsiella pneumoniae isolate.
Identification of a novel SHV-β-lactamase variant (SHV-144) in a Malaysian multidrug-resistant Klebsiella pneumoniae isolate.
Identification of a novel SHV-β-lactamase variant (SHV-144) in a Malaysian multidrug-resistant Klebsiella pneumoniae isolate.
Severe sepsis facilitates intestinal colonization by extended-spectrum-β-lactamase-producing Klebsiella pneumoniae and transfer of the SHV-18 resistance gene to Escherichia coli during antimicrobial treatment.
The study identifies the SHV-18 resistance gene, an extended-spectrum beta-lactamase, which was transferred from Klebsiella pneumoniae to Escherichia coli during ceftriaxone treatment. This gene conferred resistance to ceftriaxone and ceftazidime.
A Review of Ten Years of the Study for Monitoring Antimicrobial Resistance Trends (SMART) from 2002 to 2011.
The SMART study analyzed antimicrobial resistance trends in Gram-negative bacilli, identifying new beta-lactamase variants (blaSHV-129, blaKPC-11) and highlighting the prevalence of carbapenem resistance mechanisms such as NDM-1.
Detection of SHV type Extended-Spectrum B-lactamase and Risk Factors in Pseudomonas aeruginosa Clinical Isolates.
The study detected the SHV type extended-spectrum beta-lactamase in 10.57% of Pseudomonas aeruginosa clinical isolates and identified risk factors associated with SHV-positive ESBL production.
Clinical and microbiological characteristics of tigecycline non-susceptible Klebsiella pneumoniae bacteremia in Taiwan.
The study identified bla CTX-M, bla SHV, and bla DHA-1 genes as responsible for tigecycline non-susceptibility in Klebsiella pneumoniae isolates, contributing to resistance against various beta-lactam antibiotics.
Outbreak of an armA methyltransferase-producing ST39 Klebsiella pneumoniae clone in a pediatric Algerian Hospital.
Outbreak of an armA methyltransferase-producing ST39 Klebsiella pneumoniae clone in a pediatric Algerian Hospital.
Outbreak of an armA methyltransferase-producing ST39 Klebsiella pneumoniae clone in a pediatric Algerian Hospital.
A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and β-lactam resistance genes in the gut microbiota.
The study identified numerous aminoglycoside and β-lactam resistance gene homologues in the gut microbiota of healthy adults, indicating that the human gut microbiota serves as a reservoir for antibiotic resistance genes even in the absence of recent antibiotic exposure.
Modified CLSI extended-spectrum beta-lactamase (ESBL) confirmatory test for phenotypic detection of ESBLs among Enterobacteriaceae producing various beta-lactamases.
The study evaluated a modified CLSI ESBL confirmatory test for the phenotypic detection of extended-spectrum beta-lactamases (ESBLs) among Enterobacteriaceae producing various beta-lactamases, including KPC, VIM, NDM, and OXA-48. The modified test significantly improved the sensitivity and specificity of ESBL detection compared to the standard CLSI test.
Modified CLSI extended-spectrum beta-lactamase (ESBL) confirmatory test for phenotypic detection of ESBLs among Enterobacteriaceae producing various beta-lactamases.
The study evaluated a modified CLSI ESBL confirmatory test for the phenotypic detection of extended-spectrum beta-lactamases (ESBLs) among Enterobacteriaceae producing various beta-lactamases, including KPC, VIM, NDM, and OXA-48. The modified test significantly improved the sensitivity and specificity of ESBL detection compared to the standard CLSI test.
Successful control of a neonatal outbreak caused mainly by ST20 multidrug-resistant SHV-5-producing Klebsiella pneumoniae, Greece.
The study reports on an outbreak of multidrug-resistant SHV-5-producing Klebsiella pneumoniae (ST20) in a neonatal intensive care unit in Greece. SHV-5 and TEM-1 beta-lactamases were identified as the primary mechanisms of resistance.
Extended-spectrum beta-lactamases in Escherichia coli and Klebsiella pneumoniae in Gulls, Alaska, USA.
The study identified the presence of extended-spectrum beta-lactamases (ESBLs) in Escherichia coli and Klebsiella pneumoniae isolates from gulls in Alaska, including bla CTX-M, bla SHV, and bla TEM genes.
Resistance determinants and mobile genetic elements of an NDM-1-encoding Klebsiella pneumoniae strain.
The study identifies multiple antibiotic resistance genes in the NDM-1-encoding Klebsiella pneumoniae strain, including eight beta-lactamase genes and various other resistance determinants, highlighting the complexity of its resistance profile.
Study of a Natural Mutant SHV-Type β -Lactamase, SHV-104, from Klebsiella pneumoniae.
The study identifies a novel SHV-type beta-lactamase, SHV-104, with a single point mutation (R202S) and characterizes its enzymatic properties. Additionally, the plasmid-borne CTX-M-28 beta-lactamase was identified as a significant contributor to the multidrug-resistant phenotype of the isolate.
Study of a Natural Mutant SHV-Type β -Lactamase, SHV-104, from Klebsiella pneumoniae.
Study of a Natural Mutant SHV-Type β -Lactamase, SHV-104, from Klebsiella pneumoniae.
Study of a Natural Mutant SHV-Type β -Lactamase, SHV-104, from Klebsiella pneumoniae.
Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system.
The study identifies blaKPC-2 and blaKPC-3 as the primary carbapenem resistance genes in KPC-producing Enterobacter isolates, along with various ESBL genes such as blaSHV-5, blaSHV-12, blaSHV-154, blaCTX-M-15, and blaTEM-1. Additionally, plasmid-mediated fluoroquinolone resistance genes qnrA and qnrB were detected.
Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system.
The study identifies blaKPC-2 and blaKPC-3 as the primary carbapenem resistance genes in KPC-producing Enterobacter isolates, along with various ESBL genes such as blaSHV-5, blaSHV-12, blaSHV-154, blaCTX-M-15, and blaTEM-1. Additionally, plasmid-mediated fluoroquinolone resistance genes qnrA and qnrB were detected.
Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system.
The study identifies blaKPC-2 and blaKPC-3 as the primary carbapenem resistance genes in KPC-producing Enterobacter isolates, along with various ESBL genes such as blaSHV-5, blaSHV-12, blaSHV-154, blaCTX-M-15, and blaTEM-1. Additionally, plasmid-mediated fluoroquinolone resistance genes qnrA and qnrB were detected.
Rapid Detection of Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae from Urine Samples by Use of the ESBL NDP Test
The study describes the rapid detection of extended-spectrum-beta-lactamase (ESBL)-producing Enterobacteriaceae from urine samples using the ESBL NDP test. It identifies various ESBL genes, including blaCTX-M-1, blaCTX-M-15, blaCTX-M-3, blaTEM-1, blaSHV-1, and blaTEM-24, which confer resistance to cefotaxime, ceftazidime, and cefepime.
Prevalence and impact of extended-spectrum β-lactamase production on clinical outcomes in cancer patients with Enterobacter species bacteremia.
The study found that 15.3% of Enterobacter spp. blood isolates from cancer patients produced extended-spectrum β-lactamases (ESBLs), primarily CTX-M, SHV-12, and TEM types. While ESBL-positive isolates were associated with more frequent inappropriate empirical antimicrobial therapy, they did not lead to worse clinical outcomes.
Co-existence of beta-lactamases in clinical isolates of Escherichia coli from Kathmandu, Nepal.
The study reports the high prevalence of bla CTX-M-type ESBL and co-existence of ESBLs and carbapenemases in E. coli isolates from Kathmandu, Nepal. It identifies multiple beta-lactamase genes including bla CTX-M, bla SHV, bla TEM, bla VIM, bla IMP, and bla NDM-1.
Genomic Analysis of Antimicrobial Resistance in Clinical Isolates of Escherichia coli
The study identified various AMR genes in ExPEC E. coli strains, including beta-lactamases (blaCTX-M, blaSHV, blaTEM), quinolone resistance genes (qnrS1), aminoglycoside modifying enzymes (aac(6')-Ib, aadA), tetracycline resistance genes (tet(A)), macrolide resistance genes (mph(A), erm(B), mef(A)), and others. These genes were associated with resistance to multiple antibiotics.
Plasmid-mediated resistance to cephalosporins and fluoroquinolones in various Escherichia coli sequence types isolated from rooks wintering in Europe.
The study identified several plasmid-mediated resistance genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-24, bla TEM-52, bla CTX-M-14, bla CTX-M-55, bla SHV-12, bla CTX-M-8, bla CTX-M-25, bla CTX-M-28, bla CMY-2, qnrS1, qnrB19, and aac(6′)-Ib-cr, in Escherichia coli isolates from rooks in Europe.
Trends in serotype distribution and antimicrobial susceptibility in Salmonella enterica isolates from humans in Belgium, 2009 to 2013.
The study identifies plasmid-mediated quinolone resistance (PMQR) alleles qnrS1, qnrD1, and qnrB, as well as beta-lactamase genes blaSHV-12, blaTEM-52, blaCTX-M-14, and blaCTX-M-15 in Salmonella enterica isolates from Belgium. It also reports chromosomal mutations in gyrA and parC contributing to fluoroquinolone resistance.
β-lactamases produced by amoxicillin-clavulanate-resistant enterobacteria isolated in Buenos Aires, Argentina: a new blaTEM gene.
The study identified a new blaTEM variant, blaTEM-163, which confers resistance to amoxicillin-clavulanic acid. It also characterized blaTEM-1b and blaTEM-1a as prevalent alleles among amoxicillin-clavulanic acid-resistant enterobacteria.
Drug resistance profiles and clonality of sporadic Shigella sonnei isolates in Ankara, Turkey
The study identified blaSHV-12, blaTEM-1, and blaCTX-M-15 genes in ESBL-producing Shigella sonnei isolates, highlighting the presence of multidrug-resistant strains in Ankara, Turkey.
Insight into the effect of inhibitor resistant S130G mutant on physico-chemical properties of SHV type beta-lactamase: a molecular dynamics study.
The S130G mutation in SHV beta-lactamase reduces the effectiveness of clavulanic acid, a beta-lactamase inhibitor, by altering the active site and decreasing hydrogen bonding and hydrophobic interactions.
Insight into the effect of inhibitor resistant S130G mutant on physico-chemical properties of SHV type beta-lactamase: a molecular dynamics study.
The S130G mutation in SHV beta-lactamase reduces the effectiveness of clavulanic acid, a beta-lactamase inhibitor, by altering the active site and decreasing hydrogen bonding and hydrophobic interactions.
Multiresistant bacteria isolated from chicken meat in Austria.
The study identified ESBL-producing E. coli with bla SHV-12, bla CTX-m-1, and bla SHV-2 genes, VRE with van A and van B genes, and MRCNS with the mec A gene in chicken meat samples from Austria.
Multiresistant bacteria isolated from chicken meat in Austria.
The study identified ESBL-producing E. coli with bla SHV-12, bla CTX-m-1, and bla SHV-2 genes, VRE with van A and van B genes, and MRCNS with the mec A gene in chicken meat samples from Austria.
Detecting a quasi-stable imine species on the reaction pathway of SHV-1 beta-lactamase and 6β-(hydroxymethyl)penicillanic acid sulfone.
The study characterizes the beta-lactamase SHV-1 and investigates the inhibitory effects of PSR-3-283A, a 6β-(hydroxymethyl)penicillanic acid sulfone, against SHV-1. PSR-3-283A exhibits improved inhibitory properties compared to sulbactam, with a slower deacylation rate and enhanced affinity.
Impact of the use of β-lactam antimicrobials on the emergence of Escherichia coli isolates resistant to cephalosporins under standard pig-rearing conditions.
The study identified several cephalosporin resistance genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-9, bla CTX-M-15, and bla SHV-12, in Escherichia coli isolates from pigs. These genes were associated with the emergence of cephalosporin-resistant E. coli under standard pig-rearing conditions.
Fluoroquinolone-resistant and extended-spectrum β-lactamase-producing Escherichia coli from the milk of cows with clinical mastitis in Southern Taiwan.
The study identified several extended-spectrum beta-lactamase (ESBL) genes including bla TEM, bla CMY, bla CTX, bla SHV, and bla DHA in Escherichia coli isolates from cows with clinical mastitis. Additionally, mutations in gyrA and parC were associated with fluoroquinolone resistance.
Prevalence of virulence determinants and antimicrobial resistance among commensal Escherichia coli derived from dairy and beef cattle.
The study identified several antimicrobial resistance genes in commensal E. coli from dairy and beef cattle, including blaTEM, blaSHV, aadA1, tetA, tetB, and tetC. These genes conferred resistance to ampicillin, streptomycin, and tetracycline. Dairy cattle isolates showed higher resistance rates compared to beef cattle.
Phenotypic and Molecular Characterization of Extended-Spectrum β-Lactamase Produced by Escherichia coli, and Klebsiella pneumoniae Isolates in an Educational Hospital.
The study identified the presence of blaTEM and blaSHV genes in E. coli and K. pneumoniae isolates, which confer resistance to various beta-lactam antibiotics, highlighting the prevalence of extended-spectrum beta-lactamases in these pathogens.
Increase in resistance to extended-spectrum cephalosporins in Salmonella isolated from retail chicken products in Japan.
The study identified the presence of plasmid-mediated extended-spectrum cephalosporin resistance genes, including bla CMY-2, bla CTX-M-2, bla CTX-M-15, bla TEM-20, bla TEM-52, and bla SHV-12, in Salmonella isolates from chicken products in Japan. These genes were associated with resistance to various cephalosporins and other beta-lactam antibiotics.
Avibactam and inhibitor-resistant SHV β-lactamases.
Avibactam and inhibitor-resistant SHV β-lactamases.
Avibactam and inhibitor-resistant SHV β-lactamases.
Avibactam and inhibitor-resistant SHV β-lactamases.
Avibactam and inhibitor-resistant SHV β-lactamases.
Avibactam and inhibitor-resistant SHV β-lactamases.
Extended-spectrum-β-lactamase-producing Enterobacteriaceae isolated from vegetables imported from the Dominican Republic, India, Thailand, and Vietnam.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-55, bla CTX-M-65, bla CTX-M-1, bla CTX-M-3, bla CTX-M-27, bla CTX-M-63, bla SHV-2, bla SHV-12, and bla SHV-2a, in ESBL-producing Enterobacteriaceae isolated from vegetables imported into Switzerland.
Extended-spectrum-β-lactamase-producing Enterobacteriaceae isolated from vegetables imported from the Dominican Republic, India, Thailand, and Vietnam.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-55, bla CTX-M-65, bla CTX-M-1, bla CTX-M-3, bla CTX-M-27, bla CTX-M-63, bla SHV-2, bla SHV-12, and bla SHV-2a, in ESBL-producing Enterobacteriaceae isolated from vegetables imported into Switzerland.
Extended-spectrum-β-lactamase-producing Enterobacteriaceae isolated from vegetables imported from the Dominican Republic, India, Thailand, and Vietnam.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-55, bla CTX-M-65, bla CTX-M-1, bla CTX-M-3, bla CTX-M-27, bla CTX-M-63, bla SHV-2, bla SHV-12, and bla SHV-2a, in ESBL-producing Enterobacteriaceae isolated from vegetables imported into Switzerland.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases.
The study characterizes the activity of ceftazidime, ceftaroline, and aztreonam in combination with avibactam against isogenic E. coli strains expressing various beta-lactamase genes, demonstrating that avibactam effectively restores the activity of these β-lactams against strains producing class A, C, and D beta-lactamases.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases.
The study characterizes the activity of ceftazidime, ceftaroline, and aztreonam in combination with avibactam against isogenic E. coli strains expressing various beta-lactamase genes, demonstrating that avibactam effectively restores the activity of these β-lactams against strains producing class A, C, and D beta-lactamases.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases.
The study characterizes the activity of ceftazidime, ceftaroline, and aztreonam in combination with avibactam against isogenic E. coli strains expressing various beta-lactamase genes, demonstrating that avibactam effectively restores the activity of these β-lactams against strains producing class A, C, and D beta-lactamases.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases.
The study characterizes the activity of ceftazidime, ceftaroline, and aztreonam in combination with avibactam against isogenic E. coli strains expressing various beta-lactamase genes, demonstrating that avibactam effectively restores the activity of these β-lactams against strains producing class A, C, and D beta-lactamases.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases.
The study characterizes the activity of ceftazidime, ceftaroline, and aztreonam in combination with avibactam against isogenic E. coli strains expressing various beta-lactamase genes, demonstrating that avibactam effectively restores the activity of these β-lactams against strains producing class A, C, and D beta-lactamases.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases.
The study characterizes the activity of ceftazidime, ceftaroline, and aztreonam in combination with avibactam against isogenic E. coli strains expressing various beta-lactamase genes, demonstrating that avibactam effectively restores the activity of these β-lactams against strains producing class A, C, and D beta-lactamases.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases.
The study characterizes the activity of ceftazidime, ceftaroline, and aztreonam in combination with avibactam against isogenic E. coli strains expressing various beta-lactamase genes, demonstrating that avibactam effectively restores the activity of these β-lactams against strains producing class A, C, and D beta-lactamases.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases.
The study characterizes the activity of ceftazidime, ceftaroline, and aztreonam in combination with avibactam against isogenic E. coli strains expressing various beta-lactamase genes, demonstrating that avibactam effectively restores the activity of these β-lactams against strains producing class A, C, and D beta-lactamases.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases.
The study characterizes the activity of ceftazidime, ceftaroline, and aztreonam in combination with avibactam against isogenic E. coli strains expressing various beta-lactamase genes, demonstrating that avibactam effectively restores the activity of these β-lactams against strains producing class A, C, and D beta-lactamases.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single β-lactamases.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single β-lactamases.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single β-lactamases.
TEM and SHV Genes in Klebsiella pneumoniae Isolated from Cockroaches and Their Antimicrobial Resistance Pattern.
The study identified the presence of TEM and SHV genes in K. pneumoniae isolated from cockroaches, which conferred resistance to several beta-lactam antibiotics. Imipenem showed 100% sensitivity against the isolates.
Longitudinal study of extended-spectrum-β-lactamase- and AmpC-producing Enterobacteriaceae in household dogs.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla SHV-12, and bla CMY-2, in ESBL-producing Enterobacteriaceae isolated from household dogs. These genes were found to confer resistance to various beta-lactam antibiotics.
Frequency of PER, VEB, SHV, TEM and CTX-M Genes in Resistant Strains of Pseudomonas aeruginosa Producing Extended Spectrum beta-lactamases.
The study identified blaTEM-116, blaVEB-1, and blaPER-1 as the most prevalent ESBL genes in Pseudomonas aeruginosa isolates from Zahedan, Iran, with blaTEM being 100% prevalent.
Carbapenem-nonsusceptible Enterobacteriaceae in Taiwan.
The study identified several carbapenemase genes, including blaKPC-2, blaIMP-8, blaNDM-1, and blaVIM-1, along with extended-spectrum beta-lactamase genes such as CTX-M, SHV, and ampC beta-lactamase genes like DHA and CMY, which contribute to carbapenem resistance in Enterobacteriaceae isolates in Taiwan.
Improved detection of extended spectrum beta-lactamase (ESBL)-producing Escherichia coli in input and output samples of German biogas plants by a selective pre-enrichment procedure.
The study identified bla CTX-M, bla TEM, and bla SHV genes in ESBL-producing E. coli isolates from input and output samples of German biogas plants, highlighting the persistence of these resistance genes despite the biogas process.
Clinical epidemiology and molecular analysis of extended-spectrum-β-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types 131 and 648.
The study identified bla CTX-M-15, aac (3)-IIa, aadA1, aadA2, aadA5, qnrB4, qnrS1, aac (6')-Ib-cr, bla OXA-1, bla TEM-1B, bla SHV-12, bla CMY-42, bla DHA-1, mphA, ermB, catA1, catB3, sul1, sul2, dfrA12, dfrA17, dfrA1, dfrA5, tetA, tetB, and tetD as key AMR genes in ESBL-producing E. coli isolates in Nepal, highlighting the prevalence of multidrug resistance.
Molecular evaluations of extended spectrum beta-lactamase producing strains of Serratia isolated from blood samples of the patients in Namazi Hospital, Shiraz, Southern Iran.
The study identified bla OXA-1 and bla SHV-1 genes as the primary contributors to ESBL production in Serratia strains, with bla OXA-1 being the most prevalent. No bla TEM genes were detected.
Development of a multiplex-PCR probe system for the proper identification of Klebsiella variicola.
The study developed a multiplex-PCR system for the accurate identification of Klebsiella variicola, highlighting the mtnC gene as a specific molecular marker for the Klebsiella genus.
Development of a multiplex-PCR probe system for the proper identification of Klebsiella variicola.
The study developed a multiplex-PCR system for the accurate identification of Klebsiella variicola, highlighting the mtnC gene as a specific molecular marker for the Klebsiella genus.
Development of a multiplex-PCR probe system for the proper identification of Klebsiella variicola.
The study developed a multiplex-PCR system for the accurate identification of Klebsiella variicola, highlighting the mtnC gene as a specific molecular marker for the Klebsiella genus.
Multidrug-resistant phenotype and isolation of a novel SHV- beta-Lactamase variant in a clinical isolate of Enterobacter cloacae.
A novel SHV-type beta-lactamase, SHV-128, was identified in a multidrug-resistant Enterobacter cloacae isolate. This enzyme conferred resistance to ceftazidime, cefotaxime, and aztreonam.
Multidrug-resistant phenotype and isolation of a novel SHV- beta-Lactamase variant in a clinical isolate of Enterobacter cloacae.
Multidrug-resistant phenotype and isolation of a novel SHV- beta-Lactamase variant in a clinical isolate of Enterobacter cloacae.
Multidrug-resistant phenotype and isolation of a novel SHV- beta-Lactamase variant in a clinical isolate of Enterobacter cloacae.
Multidrug-resistant phenotype and isolation of a novel SHV- beta-Lactamase variant in a clinical isolate of Enterobacter cloacae.
Simple multiplex PCR assays to detect common pathogens and associated genes encoding for acquired extended spectrum betalactamases (ESBL) or carbapenemases from surgical site specimens in Vietnam.
The study identified several AMR genes including SHV, CTX-M, TEM, NDM-1, PER-1, Oxa23, and Oxa58 in surgical site infection specimens in Vietnam.
Characterization of pre-antibiotic era Klebsiella pneumoniae isolates with respect to antibiotic/disinfectant susceptibility and virulence in Galleria mellonella.
The study identified blaSHV genes as the cause of penicillin resistance in pre-antibiotic era Klebsiella pneumoniae isolates. Some isolates with blaSHV genes showed resistance to penicillins, and mutations in these genes could enhance resistance.
Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV beta-lactamases with single amino acid substitutions in the Ω-loop.
The study identified that certain KPC-2 variants with single amino acid substitutions in the Ω-loop exhibited resistance to ceftazidime/avibactam, highlighting the potential for these mutations to reduce the efficacy of this antibiotic combination.
Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV β-lactamases with single amino acid substitutions in the Ω-loop.
Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV β-lactamases with single amino acid substitutions in the Ω-loop.
Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV β-lactamases with single amino acid substitutions in the Ω-loop.
Molecular characteristics of extended-spectrum cephalosporin-resistant Enterobacteriaceae from humans in the community.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and others, as well as plasmidic AmpC genes like bla CMY-2 and bla DHA-1, in various Enterobacteriaceae isolates from healthy humans in the community.
Molecular characteristics of extended-spectrum cephalosporin-resistant Enterobacteriaceae from humans in the community.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and others, as well as plasmidic AmpC genes like bla CMY-2 and bla DHA-1, in various Enterobacteriaceae isolates from healthy humans in the community.
Occurrence of SHV, TEM and CTX-M beta-lactamase Genes Among Enteropathogenic Escherichia coli Strains Isolated From Children With Diarrhea.
The study identified the presence of bla CTX-M1, bla CTX-M15, bla SHV, and bla TEM genes in EPEC isolates, highlighting the prevalence of ESBLs and their role in antibiotic resistance.
Identification and characterization of a novel incompatibility group X3 plasmid carrying bla NDM-1 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China.
Characterization of Multidrug Resistant Extended-Spectrum Beta-Lactamase-Producing Escherichia coli among Uropathogens of Pediatrics in North of Iran.
The study identified TEM, SHV, CTX, and VEB beta-lactamase genes as the primary drivers of extended-spectrum beta-lactamase production in E. coli isolates from pediatric patients in northern Iran, with TEM being the most prevalent. These genes conferred resistance to various beta-lactam antibiotics.
Occurrence of Multidrug Resistant Extended Spectrum Beta-Lactamase-Producing Bacteria on Iceberg Lettuce Retailed for Human Consumption.
The study identified ESBL-producing bacteria on iceberg lettuce, including K. pneumoniae isolates carrying SHV-type and TEM-type beta-lactamase genes, as well as S. marcescens with a CTX-M-1 beta-lactamase. These genes confer resistance to cefotaxime.
In Vitro Activity of Imipenem and Colistin against a Carbapenem-Resistant Klebsiella pneumoniae Isolate Coproducing SHV-31, CMY-2, and DHA-1.
The study identified the presence of blaSHV-31, blaCMY-2, and blaDHA-1 genes in a carbapenem-resistant K. pneumoniae isolate, along with mutations in ompK35 and loss of ompK36, contributing to resistance against multiple antibiotics.
Point-of-care multiplex PCR promises short turnaround times for microbial testing in hospital-acquired pneumonia--an observational pilot study in critical ill patients.
The study evaluated the performance of a point-of-care multiplex PCR system for detecting pathogens and antibiotic resistance markers in hospital-acquired pneumonia. The system showed significantly shorter turnaround times compared to conventional microbiological diagnostics, although its performance was limited by frequent test failures and non-concordant results.
Detection of the SHV genotype polymorphism of the extended-spectrum beta-lactamase-producing Gram-negative bacterium.
The study identified novel mutations in the blaSHV gene, including L35Q, I8F, R43S, G238S, G238A, and E240K, which contribute to resistance against various β-lactam antibiotics.
Detection of the SHV genotype polymorphism of the extended-spectrum β-lactamase-producing Gram-negative bacterium.
Detection of the SHV genotype polymorphism of the extended-spectrum β-lactamase-producing Gram-negative bacterium.
Detection of the SHV genotype polymorphism of the extended-spectrum β-lactamase-producing Gram-negative bacterium.
Detection of the SHV genotype polymorphism of the extended-spectrum β-lactamase-producing Gram-negative bacterium.
Detection of the SHV genotype polymorphism of the extended-spectrum β-lactamase-producing Gram-negative bacterium.
First description of plasmid-mediated quinolone resistance determinants and β-lactamase encoding genes in non-typhoidal Salmonella isolated from humans, one companion animal and food in Romania.
The study identified plasmid-mediated quinolone resistance (PMQR) genes such as qnrA, qnrB, qnrS, aac(6')-Ib-cr, and qepA, along with beta-lactamase-encoding genes like blaTEM, blaPSE-1, blaSHV, and blaCTX-M in non-typhoidal Salmonella isolates from humans, a companion animal, and food in Romania.
Sequence analysis of genes mediating extended-spectrum beta-lactamase (ESBL) production in isolates of Enterobacteriaceae in a Lagos Teaching Hospital, Nigeria.
The study identified bla CTX-M-15 as the predominant ESBL gene in Enterobacteriaceae isolates, with high prevalence among E. coli and K. pneumoniae. Additionally, bla TEM-1, bla SHV-11, bla SHV-12, and bla SHV-112 were also detected.
Sequence analysis of genes mediating extended-spectrum beta-lactamase (ESBL) production in isolates of Enterobacteriaceae in a Lagos Teaching Hospital, Nigeria.
The study identified bla CTX-M-15 as the predominant ESBL gene in Enterobacteriaceae isolates, with high prevalence among E. coli and K. pneumoniae. Additionally, bla TEM-1, bla SHV-11, bla SHV-12, and bla SHV-112 were also detected.
Sequence analysis of genes mediating extended-spectrum beta-lactamase (ESBL) production in isolates of Enterobacteriaceae in a Lagos Teaching Hospital, Nigeria.
The study identified bla CTX-M-15 as the predominant ESBL gene in Enterobacteriaceae isolates, with high prevalence among E. coli and K. pneumoniae. Additionally, bla TEM-1, bla SHV-11, bla SHV-12, and bla SHV-112 were also detected.
Emergence of concurrent infections with colistin-resistant ESBL-positive Klebsiella pneumoniae and OXA-23-producing Acinetobacter baumannii sensitive to colistin only in a Romanian cardiac intensive care unit.
The study identifies colistin-resistant ESBL-positive Klebsiella pneumoniae harboring bla CTX-M-15, bla SHV-11, bla OXA-1, bla TEM-1b, and aac(6')-Ib-cr, as well as OXA-23-producing Acinetobacter baumannii sensitive to colistin.
Complex class 1 integrons harboring CTX-M-2-encoding genes in clinical Enterobacteriaceae from a hospital in Brazil.
Complex class 1 integrons harboring CTX-M-2-encoding genes in clinical Enterobacteriaceae from a hospital in Brazil.
Complex class 1 integrons harboring CTX-M-2-encoding genes in clinical Enterobacteriaceae from a hospital in Brazil.
Rapid Molecular Diagnostics, Antibiotic Treatment Decisions, and Developing Approaches to Inform Empiric Therapy: PRIMERS I and II.
Rapid Molecular Diagnostics, Antibiotic Treatment Decisions, and Developing Approaches to Inform Empiric Therapy: PRIMERS I and II.
Rapid Molecular Diagnostics, Antibiotic Treatment Decisions, and Developing Approaches to Inform Empiric Therapy: PRIMERS I and II.
Dissemination of Extended-Spectrum beta-lactamases and Quinolone Resistance Genes Among Clinical Isolates of Uropathogenic Escherichia coli in Children.
The study identified the prevalence of extended-spectrum beta-lactamase (ESBL) genes (bla-CTX-M, bla-SHV, bla-TEM) and quinolone resistance genes (qnrB, qnrS) in uropathogenic E. coli isolates from children with urinary tract infections. bla-CTX-M was the most prevalent ESBL gene, while qnrB and qnrS were the most commonly detected quinolone resistance genes.
Factors Associated to Prevalence and Incidence of Carbapenem-Resistant Enterobacteriaceae Fecal Carriage: A Cohort Study in a Mexican Tertiary Care Hospital.
The study identified OXA-232, CTX-M-15, SHV, NDM-1, KPC-1, and IMP as the primary molecular mechanisms of carbapenem resistance in CRE isolates. These genes were detected through PCR and sequencing.
Performance Evaluation of the Verigene Gram-Positive and Gram-Negative Blood Culture Test for Direct Identification of Bacteria and Their Resistance Determinants from Positive Blood Cultures in Hong Kong.
The Verigene Blood Culture Test effectively identifies bacteria and their resistance determinants, including bla CTX-M, bla OXA, vanA, and mecA genes, demonstrating high sensitivity and specificity for detecting antimicrobial resistance in clinical settings.
Ultrastructural Changes in Clinical and Microbiota Isolates of Klebsiella pneumoniae Carriers of Genes bla SHV, bla TEM, bla CTX-M, or bla KPC When Subject to β-Lactam Antibiotics.
The study identified the presence of bla TEM, bla SHV, bla CTX-M, and bla KPC genes in K. pneumoniae isolates, which confer resistance to various β-lactam antibiotics. The isolates exhibited ultrastructural changes when exposed to sub-MICs of these antibiotics.
SHV-129: A Gateway to Global Suppressors in the SHV beta-lactamase Family?
The study identifies SHV-129, a beta-lactamase variant with mutations G238S, E240K, R275L, and N276D, which enhances resistance to cephalosporins and cefepime. The R275L and N276D mutations act as stabilizing suppressors, contributing to the enzyme's stability and resistance profile.
β-Lactamase Characterization of Gram-Negative Pathogens Recovered from Patients Enrolled in the Phase 2 Trials for Ceftazidime-Avibactam: Clinical Efficacies Analyzed against Subsets of Molecularly Characterized Isolates.
The study characterized β-lactamase genes in baseline pathogens from patients enrolled in phase 2 trials for ceftazidime-avibactam, identifying CTX-M-14, CTX-M-15, OXA-1, TEM-1, OXA-1/30, SHV-12, ACC-4, CMY-42, NDM-1, VIM-2, PER-1, and OXA-23 as key resistance determinants against ceftazidime.
Complete Sequence of a Novel IncR-F33:A–:B– Plasmid, pKP1034, Harboring fosA3, blaKPC-2, blaCTX-M-65, blaSHV-12, and rmtB from an Epidemic Klebsiella pneumoniae Sequence Type 11 Strain in China.
The study identifies a novel plasmid pKP1034 carrying multiple resistance genes including fosA3, blaKPC-2, blaCTX-M-65, blaSHV-12, and rmtB in a Klebsiella pneumoniae ST11 strain, highlighting the complex resistance mechanisms and potential for horizontal gene transfer.
Identification of Extended-Spectrum β-Lactamases Escherichia coli Strains Isolated from Market Garden Products and Irrigation Water in Benin.
The study identified bla TEM, bla SHV, and bla CTX-M genes in E. coli strains isolated from market garden products and irrigation water in Benin, indicating resistance to amoxicillin.
First description of SHV-148 mediated extended-spectrum cephalosporin resistance among clinical isolates of Escherichia coli from India.
The study reports the first occurrence of SHV-148-mediated extended-spectrum cephalosporin resistance in clinical isolates of Escherichia coli from India, highlighting its association with IS26 and Class 1 integrons, and its horizontal transfer capability via IncF plasmids.
Outbreak of plasmid-mediated NDM-1-producing Klebsiella pneumoniae ST105 among neonatal patients in Yunnan, China.
The study identifies blaNDM-1, blaIMP-4, blaCTX-M-15, blaSHV-1, qnrS1, qnrB4, and aacA4 as the primary resistance genes in NDM-1-producing K. pneumoniae ST105 isolates during an outbreak in a neonatal ICU in China.
Molecular characterization of the gene encoding SHV-3 beta-lactamase responsible for transferable cefotaxime resistance in clinical isolates of Klebsiella pneumoniae.
The study identified the SHV-3 beta-lactamase gene responsible for cefotaxime resistance in Klebsiella pneumoniae, showing it differs from SHV-1 by two amino acid substitutions.
Molecular characterization of the gene encoding SHV-3 beta-lactamase responsible for transferable cefotaxime resistance in clinical isolates of Klebsiella pneumoniae.
Molecular characterization of the gene encoding SHV-3 beta-lactamase responsible for transferable cefotaxime resistance in clinical isolates of Klebsiella pneumoniae.
Molecular characterization of the gene encoding SHV-3 beta-lactamase responsible for transferable cefotaxime resistance in clinical isolates of Klebsiella pneumoniae.
Molecular characterization of the gene encoding SHV-3 beta-lactamase responsible for transferable cefotaxime resistance in clinical isolates of Klebsiella pneumoniae.
Detection and characterization of extended-spectrum beta-lactamases (blaCTX-M-1 and blaSHV ) producing Escherichia coli, Salmonella spp. and Klebsiella pneumoniae isolated from humans in Mizoram.
The study identified blaCTX-M-1 and blaSHV genes in Escherichia coli, Salmonella spp., and Klebsiella pneumoniae isolates from human fecal samples in Mizoram, indicating the presence of extended-spectrum beta-lactamases conferring resistance to cephalosporins.
Frequency, Antimicrobial Resistance and Genetic Diversity of Klebsiella pneumoniae in Food Samples.
The study identified various AMR genes and mutations in K. pneumoniae isolates from food samples, including beta-lactamases (blaSHV, blaCTX-M-1, blaCTX-M-10), folate pathway inhibitor gene (dhfr), quinolone resistance genes (qnrB, qnrA, qnrS, aac(6')-Ib-cr), aminoglycoside resistance genes (aacA4, aacC2, aadA1), and mutations in gyrA and parC genes associated with fluoroquinolone resistance.
Characterization of Antibiotic Resistance Profiles of Ocular Enterobacteriaceae Isolates.
The study identified ESBL genes (blaCTX-M, blaOXA, blaSHV, blaTEM), QNR genes (qnrA, qnrB, qnrS), and gyra mutations (Ser83Leu) in ocular Enterobacteriaceae isolates, highlighting the prevalence of multidrug resistance.
Phenotypic and Molecular Assessment of Drug Resistance Profile and Genetic Diversity of Waterborne Escherichia coli.
The study identified ESBL genes (blaTEM, blaCTX-M3, blaOXA, and blaSHV) in 38% of E. coli isolates from the Nowohucki Reservoir, indicating the presence of multidrug-resistant strains. These genes confer resistance to beta-lactam antibiotics such as ampicillin and ticarcillin.
Detection of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Market-Ready Chickens in Zambia.
The study detected ESBL-producing E. coli in poultry in Zambia, identifying blaCTX-M, blaSHV, and blaTEM genes as responsible for beta-lactam resistance.
Characterization of ESBL- and AmpC-Producing and Fluoroquinolone-Resistant Enterobacteriaceae Isolated from Mouflons (Ovis orientalis musimon) in Austria and Germany.
The study identified ESBL- and AmpC-producing Enterobacteriaceae in a mouflon, including E. coli ST744 carrying bla CTX-M-15 and bla OXA-1, and K. pneumoniae ST11 carrying bla SHV-11, bla OXA-1, bla DHA-1, and the PMQR gene qnrB55.
Fecal Colonization with Extended-Spectrum Beta-Lactamase and AmpC-Producing Escherichia coli.
The study identified ES β L and AmpC-producing E. coli isolates in fecal samples, with bla CTX-M-15 being the most prevalent gene. The isolates showed resistance to various β -lactam antibiotics.
Prevalence and Diversity of Salmonella Serotypes in Ecuadorian Broilers at Slaughter Age.
The study identified the presence of bla CTX-M, bla TEM, bla SHV, and bla CMY genes in cefotaxime-resistant Salmonella isolates, as well as the mcr-1 gene in colistin-resistant isolates. S. Infantis showed high resistance rates to multiple antibiotics, including sulfamethoxazole, nalidixic acid, and ciprofloxacin.
KPC-3-Producing Klebsiella pneumoniae in Portugal Linked to Previously Circulating Non-CG258 Lineages and Uncommon Genetic Platforms (Tn4401d-IncFIA and Tn4401d-IncN).
KPC-3-Producing Klebsiella pneumoniae in Portugal Linked to Previously Circulating Non-CG258 Lineages and Uncommon Genetic Platforms (Tn4401d-IncFIA and Tn4401d-IncN).
KPC-3-Producing Klebsiella pneumoniae in Portugal Linked to Previously Circulating Non-CG258 Lineages and Uncommon Genetic Platforms (Tn4401d-IncFIA and Tn4401d-IncN).
KPC-3-Producing Klebsiella pneumoniae in Portugal Linked to Previously Circulating Non-CG258 Lineages and Uncommon Genetic Platforms (Tn4401d-IncFIA and Tn4401d-IncN).
Phenotypic and Molecular Characterization of Antimicrobial Resistance in Klebsiella spp. Isolates from Companion Animals in Japan: Clonal Dissemination of Multidrug-Resistant Extended-Spectrum beta-lactamase-Producing Klebsiella pneumoniae.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-15, blaCTX-M-14, blaCTX-M-55, and blaSHV-2, as well as the AmpC beta-lactamase gene blaDHA-1, in multidrug-resistant Klebsiella pneumoniae isolates from companion animals in Japan. Additionally, plasmid-mediated quinolone resistance (PMQR) genes such as qnrS, qnrB, aac(6')-Ib-cr, and oqxAB were detected, contributing to resistance against fluoroquinolones and aminoglycosides.
Streaming algorithms for identification of pathogens and antibiotic resistance potential from real-time MinION(TM) sequencing.
The study presents a real-time analysis framework for MinION sequencing data, demonstrating the ability to identify pathogens and antibiotic resistance genes within a few hours of sequencing. Key resistance genes identified include blaSHV, mphA, strA, strB, blaTEM, sul2, blaOXA, aac3, aac6, blaCMY, blaCFE, blaLAT, blaBIL, QnrB, aadA, oqxA, tetA, oqxB, rmtC, sul1, sul3, fosA, blaNDM, oqxA, blaSHV, oqxB, aadB, sul1, sul3, blaOXA, blaOKP, fosA, blaSHV, blaOKP, blaLEN, oqxA, and oqxB.
Surveillance of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Dairy Cattle Farms in the Nile Delta, Egypt.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M1/15, bla CTX-M9, bla TEM, and bla SHV, as well as carbapenemase genes bla OXA-48 and bla OXA-181, in ESBL-producing Escherichia coli isolates from dairy cattle farms in the Nile Delta, Egypt.
Occurrence of OXA-48 Carbapenemase and Other β-Lactamase Genes in ESBL-Producing Multidrug Resistant Escherichia coli from Dogs and Cats in the United States, 2009-2013.
The study identified the presence of various β-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-123, bla CTX-M-9, bla CTX-M-14, bla TEM-1, bla SHV-12, bla CMY-2, and bla OXA-48, in ESBL-producing multidrug resistant E. coli isolates from dogs and cats in the United States. Additionally, the PMQR gene aac(6')-Ib-cr was found to be prevalent in these isolates.
Risk factors and spatial distribution of extended spectrum β-lactamase-producing- Escherichia coli at retail poultry meat markets in Malaysia: a cross-sectional study.
The study identified the presence of extended spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) in retail poultry meat markets in Malaysia, highlighting the prevalence of genes such as bla TEM, bla SHV, bla CTX-M, and bla OXA, which confer resistance to beta-lactam antibiotics.
Clinical and Molecular Characteristics of Neonatal Extended-Spectrum β-Lactamase-Producing Gram-Negative Bacteremia: A 12-Year Case-Control-Control Study of a Referral Center in Taiwan.
The study identified SHV-type, CTX-M, and TEM-type extended-spectrum beta-lactamase (ESBL) genes in neonatal Gram-negative bacteremia. These ESBLs conferred resistance to cephalosporins, and the isolates were multidrug resistant.
Detection of Extended Spectrum Beta-Lactamases Resistance Genes among Bacteria Isolated from Selected Drinking Water Distribution Channels in Southwestern Nigeria.
The study detected the presence of extended spectrum beta-lactamase (ESBL) resistance genes, including bla TEM, bla SHV, and bla CTX, in bacteria isolated from drinking water distribution channels in Southwestern Nigeria. These genes were found to confer resistance to beta-lactam antibiotics such as ampicillin, amoxicillin/clavulanic acid, and ceftiofur.
First report of TEM-104-, SHV-99-, SHV-108-, and SHV-110-producing Klebsiella pneumoniae from Iran.
This study reports the first identification of TEM-104, SHV-99, SHV-108, and SHV-110-producing Klebsiella pneumoniae in Iran, highlighting the prevalence of these extended-spectrum beta-lactamase genes among clinical isolates.
First report of TEM-104-, SHV-99-, SHV-108-, and SHV-110-producing Klebsiella pneumoniae from Iran.
This study reports the first identification of TEM-104, SHV-99, SHV-108, and SHV-110-producing Klebsiella pneumoniae in Iran, highlighting the prevalence of these extended-spectrum beta-lactamase genes among clinical isolates.
First report of TEM-104-, SHV-99-, SHV-108-, and SHV-110-producing Klebsiella pneumoniae from Iran.
This study reports the first identification of TEM-104, SHV-99, SHV-108, and SHV-110-producing Klebsiella pneumoniae in Iran, highlighting the prevalence of these extended-spectrum beta-lactamase genes among clinical isolates.
First report of TEM-104-, SHV-99-, SHV-108-, and SHV-110-producing Klebsiella pneumoniae from Iran.
This study reports the first identification of TEM-104, SHV-99, SHV-108, and SHV-110-producing Klebsiella pneumoniae in Iran, highlighting the prevalence of these extended-spectrum beta-lactamase genes among clinical isolates.
First report of TEM-104-, SHV-99-, SHV-108-, and SHV-110-producing Klebsiella pneumoniae from Iran.
This study reports the first identification of TEM-104, SHV-99, SHV-108, and SHV-110-producing Klebsiella pneumoniae in Iran, highlighting the prevalence of these extended-spectrum beta-lactamase genes among clinical isolates.
First report of TEM-104-, SHV-99-, SHV-108-, and SHV-110-producing Klebsiella pneumoniae from Iran.
This study reports the first identification of TEM-104, SHV-99, SHV-108, and SHV-110-producing Klebsiella pneumoniae in Iran, highlighting the prevalence of these extended-spectrum beta-lactamase genes among clinical isolates.
A Review of SHV Extended-Spectrum β-Lactamases: Neglected Yet Ubiquitous.
A Review of SHV Extended-Spectrum β-Lactamases: Neglected Yet Ubiquitous.
Establishment of a Simple and Quick Method for Detecting Extended-Spectrum beta-lactamase (ESBL) Genes in Bacteria.
The study established a multiplex-PCR system for rapid and accurate detection of four common ESBL genes (blaTEM, blaCTX-M-1, blaCTX-M-9, and blaSHV) in clinical bacterial isolates.
Extended-Spectrum-Beta-Lactamase- and Plasmid-Encoded Cephamycinase-Producing Enterobacteria in the Broiler Hatchery as a Potential Mode of Pseudo-Vertical Transmission.
The study identified several beta-lactamase genes, including TEM-1, TEM-52, CTX-M1, CTX-M15, CMY-2, SHV-1, and SHV-2, which confer resistance to various beta-lactam antibiotics in ESBL-/pAmpC-producing enterobacteria isolated from broiler parent flocks and hatchery environments.
Extended-Spectrum-Beta-Lactamase- and Plasmid-Encoded Cephamycinase-Producing Enterobacteria in the Broiler Hatchery as a Potential Mode of Pseudo-Vertical Transmission.
The study identified several beta-lactamase genes, including TEM-1, TEM-52, CTX-M1, CTX-M15, CMY-2, SHV-1, and SHV-2, which confer resistance to various beta-lactam antibiotics in ESBL-/pAmpC-producing enterobacteria isolated from broiler parent flocks and hatchery environments.
Draft Genome Sequence of an Extended-Spectrum-β-Lactamase-Positive Hypervirulent Klebsiella pneumoniastrain with Novel Sequence Type 2318 Isolated from a Neonate.
The study identified the presence of the extended-spectrum β-lactamase gene blaSHV-11 and the efflux pump genes oqxA and oqxB in a hypervirulent Klebsiella pneumoniae strain isolated from a neonate.
High Prevalence of β-lactamase and Plasmid-Mediated Quinolone Resistance Genes in Extended-Spectrum Cephalosporin-Resistant Escherichia coli from Dogs in Shaanxi, China.
The study identified a high prevalence of β-lactamase and plasmid-mediated quinolone resistance genes in extended-spectrum cephalosporin-resistant Escherichia coli from dogs in Shaanxi, China. Key genes included bla CTX-M-15, bla TEM-1, bla SHV-12, and aac(6')-Ib-cr, along with other β-lactamase and PMQR genes.
Community-acquired meningitis caused by a CG86 hypervirulent Klebsiella pneumoniae strain: first case report in the Caribbean.
The study reports the first case of community-acquired meningitis caused by a hypervirulent Klebsiella pneumoniae strain in the Caribbean, highlighting the presence of the blaSHV-1 gene associated with resistance to ampicillin, ticarcillin, and piperacillin.
High Prevalence of Faecal Carriage of ESBL-Producing Enterobacteriaceae among Children in Dar es Salaam, Tanzania.
The study identified bla CTX-M-15 as the predominant ESBL gene in ESBL-producing Enterobacteriaceae isolates from children in Dar es Salaam, Tanzania. Additionally, bla SHV-5/12 and bla CMY-2 were also detected in some isolates.
Isolation, Antimicrobial Susceptibility Profile and Detection of Sul1, blaTEM, and blaSHV in Amoxicillin-Clavulanate-Resistant Bacteria Isolated From Retail Sausages in Kampar, Malaysia.
The study identified blaTEM, blaSHV, and Sul1 as the primary resistance mechanisms in amoxicillin-clavulanate-resistant bacteria isolated from retail sausages in Malaysia.
ESBL-Producing Escherichia coli from Cows Suffering Mastitis in China Contain Clinical Class 1 Integrons with CTX-M Linked to ISCR1.
The study identified a high prevalence of ESBL-producing E. coli from mastitic cows in China, with blaCTX-M-15 being the most common ESBL gene. These isolates were found to carry clinical class 1 integrons and ISCR1 elements, contributing to multidrug resistance.
Antimicrobial Resistant Enteropathogenic Escherichia coli and Salmonella spp. in Houseflies Infesting Fish in Food Markets in Zambia.
The study identified ESBL-producing E. coli carrying blaCTX-M, blaSHV, and blaTEM genes in houseflies infesting fish in Zambian food markets, indicating a significant threat to public health.
Clinical and microbiologic characteristics of cefotaxime-non-susceptible Enterobacteriaceae bacteremia: a case control study.
The study identified several beta-lactamase genes, including CTX-M-14, CTX-M-27, CTX-M-15, CTX-M-55, CTX-M-2, SHV-12, SHV-27, DHA-1, and CMY-2, which confer resistance to cephalosporins in cefotaxime-non-susceptible Enterobacteriaceae isolates.
Clinical and microbiologic characteristics of cefotaxime-non-susceptible Enterobacteriaceae bacteremia: a case control study.
The study identified several beta-lactamase genes, including CTX-M-14, CTX-M-27, CTX-M-15, CTX-M-55, CTX-M-2, SHV-12, SHV-27, DHA-1, and CMY-2, which confer resistance to cephalosporins in cefotaxime-non-susceptible Enterobacteriaceae isolates.
Panel strain of Klebsiella pneumoniae for beta-lactam antibiotic evaluation: their phenotypic and genotypic characterization.
The study characterizes various AMR genes and mutations in K. pneumoniae panel strains, including beta-lactamases (bla SHV-11, bla TEM-1, bla CTX-M15, bla OXA-1, bla SHV-12, bla SHV-187, bla SHV-158, bla DHA-1, bla CMY-2), aminoglycoside modifying enzymes (aac(6')-Ib, strA, strB, aadA1, aadA2), quinolone resistance genes (qnrB66, qnrB4, oqxA, oqxB), tetracycline resistance (tet(A)), trimethoprim resistance (dfrA14), sulfonamide resistance (sul1, sul2), and porin genes (OmpK35, OmpK36).
Panel strain of Klebsiella pneumoniae for beta-lactam antibiotic evaluation: their phenotypic and genotypic characterization.
The study characterizes various AMR genes and mutations in K. pneumoniae panel strains, including beta-lactamases (bla SHV-11, bla TEM-1, bla CTX-M15, bla OXA-1, bla SHV-12, bla SHV-187, bla SHV-158, bla DHA-1, bla CMY-2), aminoglycoside modifying enzymes (aac(6')-Ib, strA, strB, aadA1, aadA2), quinolone resistance genes (qnrB66, qnrB4, oqxA, oqxB), tetracycline resistance (tet(A)), trimethoprim resistance (dfrA14), sulfonamide resistance (sul1, sul2), and porin genes (OmpK35, OmpK36).
Panel strain of Klebsiella pneumoniae for beta-lactam antibiotic evaluation: their phenotypic and genotypic characterization.
The study characterizes various AMR genes and mutations in K. pneumoniae panel strains, including beta-lactamases (bla SHV-11, bla TEM-1, bla CTX-M15, bla OXA-1, bla SHV-12, bla SHV-187, bla SHV-158, bla DHA-1, bla CMY-2), aminoglycoside modifying enzymes (aac(6')-Ib, strA, strB, aadA1, aadA2), quinolone resistance genes (qnrB66, qnrB4, oqxA, oqxB), tetracycline resistance (tet(A)), trimethoprim resistance (dfrA14), sulfonamide resistance (sul1, sul2), and porin genes (OmpK35, OmpK36).
Panel strain of Klebsiella pneumoniae for beta-lactam antibiotic evaluation: their phenotypic and genotypic characterization.
The study characterizes various AMR genes and mutations in K. pneumoniae panel strains, including beta-lactamases (bla SHV-11, bla TEM-1, bla CTX-M15, bla OXA-1, bla SHV-12, bla SHV-187, bla SHV-158, bla DHA-1, bla CMY-2), aminoglycoside modifying enzymes (aac(6')-Ib, strA, strB, aadA1, aadA2), quinolone resistance genes (qnrB66, qnrB4, oqxA, oqxB), tetracycline resistance (tet(A)), trimethoprim resistance (dfrA14), sulfonamide resistance (sul1, sul2), and porin genes (OmpK35, OmpK36).
Prevalence of TEM, SHV, and CTX-M Beta-Lactamase genes in the urinary isolates of a tertiary care hospital.
The study identified the prevalence of bla TEM, bla CTX-M, and bla SHV genes among Enterobacteriaceae isolates from urine samples, highlighting the dominance of bla TEM.
Prevalence of MDR pathogens of bacterial meningitis in Egypt and new synergistic antibiotic combinations.
The study identified several AMR genes including TEM, SHV, CTX-M, aac(6')-Ib, and qnrA in MDR isolates from bacterial meningitis patients in Egypt.
Antibiotic-Resistant Extended Spectrum ß-Lactamase- and Plasmid-Mediated AmpC-Producing Enterobacteriaceae Isolated from Retail Food Products and the Pearl River in Guangzhou, China.
The study identified various beta-lactamase genes, including blaSHV-1, blaTEM-1, blaCTX-M-55, blaCTX-M-65, blaDHA-1, blaCMY-2, blaACC-1, and blaCIT, which confer resistance to multiple beta-lactam antibiotics in Enterobacteriaceae isolated from retail food and water samples in Guangzhou, China.
Evolution and Epidemiology of Multidrug-Resistant Klebsiella pneumoniae in the United Kingdom and Ireland.
The study identifies several AMR genes and mutations associated with multidrug-resistant Klebsiella pneumoniae in the UK and Ireland, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline efflux pumps, and mutations in gyrB contributing to fluoroquinolone resistance.
Evolution and Epidemiology of Multidrug-Resistant Klebsiella pneumoniae in the United Kingdom and Ireland.
The study identifies several AMR genes and mutations associated with multidrug-resistant Klebsiella pneumoniae in the UK and Ireland, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline efflux pumps, and mutations in gyrB contributing to fluoroquinolone resistance.
Evolution and Epidemiology of Multidrug-Resistant Klebsiella pneumoniae in the United Kingdom and Ireland.
The study identifies several AMR genes and mutations associated with multidrug-resistant Klebsiella pneumoniae in the UK and Ireland, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline efflux pumps, and mutations in gyrB contributing to fluoroquinolone resistance.
Evolution and Epidemiology of Multidrug-Resistant Klebsiella pneumoniae in the United Kingdom and Ireland.
The study identifies several AMR genes and mutations associated with multidrug-resistant Klebsiella pneumoniae in the UK and Ireland, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline efflux pumps, and mutations in gyrB contributing to fluoroquinolone resistance.
Development of a Rapid Reverse Blot Hybridization Assay for Detection of Clinically Relevant Antibiotic Resistance Genes in Blood Cultures Testing Positive for Gram-Negative Bacteria.
The study developed and evaluated the REBA-EAC assay for the rapid detection of clinically relevant antibiotic resistance genes in blood cultures positive for Gram-negative bacteria. The assay successfully identified various beta-lactamase genes, including ESBLs (CTX-M, TEM, SHV), AmpC beta-lactamases (DHA, CMY-2-like, ACT), and carbapenemases (IMP, VIM, NDM, KPC, OXA-48-like, SPM).
Prevalence and Molecular Characteristics of Extended-Spectrum β-Lactamase Genes in Escherichia coli Isolated from Diarrheic Patients in China.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M, bla TEM, bla OXA, and bla SHV, in Escherichia coli isolates from diarrheic patients in China. These genes were responsible for resistance to third-generation cephalosporins.
Very high prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in bacteriemic patients hospitalized in teaching hospitals in Bamako, Mali.
The study reports a high prevalence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in bacteriemic patients in Bamako, Mali. The predominant ESBL enzyme was CTX-M-1 group, and a single E. coli strain was found to produce the OXA-181 carbapenemase, the first CPE described in Mali.
Resistance to antimicrobial drugs in different surface waters and wastewaters of Guadeloupe.
The study identified several AMR genes including blaCTX-M, blaSHV, blaTEM, qnrB19, qnrB1, aac(6')-Ib-cr, VEB-1, CMY-2, and CMY-8 in Enterobacteriaceae isolates from surface waters and wastewaters in Guadeloupe. These genes conferred resistance to various antibiotics such as ceftazidime, cefotaxime, ampicillin, ciprofloxacin, gentamicin, and cefoxitin.
Extended-spectrum beta-lactamase-producing Pseudomonas aeruginosa in camel in Egypt: potential human hazard.
The study identified the presence of extended-spectrum beta-lactamase (ESBL)-producing Pseudomonas aeruginosa in camel meat in Egypt, highlighting the potential risk of transmission to humans. The ESBL genes bla PER-1, bla CTX-M, bla SHV, and bla TEM were detected in the isolates.
Direct detection of extended-spectrum beta-lactamases (CTX-M) from blood cultures by LC-MS/MS bottom-up proteomics.
The study identifies CTX-M and SHV beta-lactamases in ESBL-positive isolates from blood cultures using LC-MS/MS proteomics and confirms their presence through molecular characterisation.
Detection of CTX-M-15 beta-lactamases in Enterobacteriaceae causing hospital- and community-acquired urinary tract infections as early as 2004, in Dar es Salaam, Tanzania.
The study identified blaCTX-M-15 and blaSHV-12 as the primary ESBL genes in Enterobacteriaceae causing urinary tract infections in Tanzania, with blaCTX-M-15 being the predominant gene.
Distribution of Integrons and Phylogenetic Groups among Enteropathogenic Escherichia coli Isolates from Children <5 Years of Age in Delhi, India.
The study identified various AMR genes including dfrA1, dfrA7, dfrA12, aadA1, aadA2, sul1, tetA, aacC1, TEM, SHV, CTX-M, OXA, NDM-1, IMP, VIM, ACT, DHA, and CMY in E. coli isolates from children in Delhi, India. These genes were associated with resistance to multiple antibiotics such as trimethoprim, streptomycin, sulfonamides, tetracycline, gentamicin, and various beta-lactams.
Outbreak by Hypermucoviscous Klebsiella pneumoniae ST11 Isolates with Carbapenem Resistance in a Tertiary Hospital in China.
The study identifies bla KPC-2, bla SHV-11, and bla CTX-M-65 as the primary resistance mechanisms in carbapenem-resistant hypermucoviscous Klebsiella pneumoniae (HMKP) isolates, highlighting the role of these genes in mediating resistance to multiple antibiotics.
Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.
The study identified 46 AMR genes or gene families in 90 Klebsiella pneumoniae isolates from Kenya, highlighting the prevalence of multidrug resistance and the diversity of resistance mechanisms.
Randomized controlled trial of piperacillin-tazobactam, cefepime and ertapenem for the treatment of urinary tract infection caused by extended-spectrum beta-lactamase-producing Escherichia coli.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-1, blaCTX-M-14, blaCTX-M-15, blaCTX-M-27, and blaSHV-2, which confer resistance to cefepime and piperacillin-tazobactam in Escherichia coli causing urinary tract infections.
Clonal Diversity of ESBL-Producing Escherichia coli Isolated from Environmental, Human and Food Samples.
The study identifies various ESBL genes, including bla CTX-M-14, bla CTX-M-1, bla SHV-12, and bla TEM-42, in ESBL-producing E. coli isolated from food, environmental, and human samples.
Association between Virulence Factors and Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae Compared to Nonproducing Isolates.
The study identifies TEM, SHV, and CTX-M-15 beta-lactamase genes as the primary resistance mechanisms in ESBL-producing K. pneumoniae isolates, highlighting their association with reduced susceptibility to multiple beta-lactam antibiotics.
Molecular detection of beta-lactamase and integron genes in clinical strains of Klebsiella pneumoniae by multiplex polymerase chain reaction.
The study identified the presence of various beta-lactamase genes (blaTEM, blaCTX-M, blaSHV, blaPER, blaGES, blaVIM, blaIMP, blaOXA, blaKPC) and integron genes (intI, intII, intIII) in clinical strains of Klebsiella pneumoniae, highlighting the prevalence of multidrug resistance.
Resistance to Ceftazidime-Avibactam Is Due to Transposition of KPC in a Porin-Deficient Strain of Klebsiella pneumoniae with Increased Efflux Activity.
The study identifies the role of blaKPC-3 and blaSHV-12 beta-lactamase genes, along with the T333N mutation in OmpK36, in conferring resistance to ceftazidime-avibactam in a porin-deficient strain of Klebsiella pneumoniae with increased efflux activity.
Induction of beta-lactamase Activity and Decreased β-Lactam Susceptibility by CO(2) in Clinical Bacterial Isolates.
The study identifies the presence of blaTEM and blaSHV beta-lactamase genes in Francisella philomiragia and Haemophilus influenzae, which are induced under 5% CO2 conditions, leading to decreased β-lactam susceptibility.
Klebsiella pneumoniae Isolates from Meningitis: Epidemiology, Virulence and Antibiotic Resistance.
The study identified several beta-lactamase genes (blaSHV-5, blaTEM-1B, blaCMY-2, and blaDHA-1) associated with resistance to cefotaxime and ceftazidime in Klebsiella pneumoniae isolates from meningitis. These genes were predominantly found in post-craniotomy meningitis isolates.
Multiple Antibiotic-Resistant, Extended Spectrum-β-Lactamase (ESBL)-Producing Enterobacteria in Fresh Seafood.
The study identified multiple ESBL genes, including bla CTX, bla SHV, bla TEM, and bla NDM-1, in ESBL-producing enterobacteria isolated from fresh seafood. These genes conferred resistance to various beta-lactam antibiotics, highlighting the presence of multidrug-resistant bacteria in seafood.
Distribution of bla(TEM), bla(SHV), and bla(CTX-M) genes among ESBL-producing P. aeruginosa isolated from Qazvin and Tehran hospitals, Iran.
The study identified blaTEM-1, blaCTX-M-15, blaSHV-1, and blaSHV-12 as the most common ESBL genes in ESBL-producing P. aeruginosa isolates from Iran.
Distribution of bla(TEM), bla(SHV), and bla(CTX-M) genes among ESBL-producing P. aeruginosa isolated from Qazvin and Tehran hospitals, Iran.
The study identified blaTEM-1, blaCTX-M-15, blaSHV-1, and blaSHV-12 as the most common ESBL genes in ESBL-producing P. aeruginosa isolates from Iran.
Beta-lactamase antimicrobial resistance in Klebsiella and Enterobacter species isolated from healthy and diarrheic dogs in Andhra Pradesh, India.
The study identified several beta-lactamase genes including bla SHV, bla TEM, bla OXA, bla CTX-M Group 1, and bla AmpC in Klebsiella and Enterobacter species isolated from dogs in India, highlighting the prevalence of beta-lactamase-mediated antimicrobial resistance.
A rapid diagnostic workflow for cefotaxime-resistant Escherichia coli and Klebsiella pneumoniae detection from blood cultures by MALDI-TOF mass spectrometry.
The study developed a rapid diagnostic workflow using MALDI-TOF MS to detect cefotaxime-resistant Escherichia coli and Klebsiella pneumoniae from blood cultures, identifying beta-lactamase genes such as bla CTX-M, bla KPC, bla SHV, and bla TEM as key contributors to resistance.
Rapid Nanopore Sequencing of Plasmids and Resistance Gene Detection in Clinical Isolates.
The study demonstrates the feasibility of rapid nanopore sequencing for detecting plasmid-borne antimicrobial resistance (AMR) genes in clinical isolates. It identifies several AMR genes, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, tetracycline resistance genes, macrolide resistance genes, and phenicol resistance genes, in both Escherichia coli and Klebsiella pneumoniae isolates.
Rapid Nanopore Sequencing of Plasmids and Resistance Gene Detection in Clinical Isolates.
The study demonstrates the feasibility of rapid nanopore sequencing for detecting plasmid-borne antimicrobial resistance (AMR) genes in clinical isolates. It identifies several AMR genes, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, tetracycline resistance genes, macrolide resistance genes, and phenicol resistance genes, in both Escherichia coli and Klebsiella pneumoniae isolates.
Phenotypic and Molecular Characterization of Multidrug Resistant Klebsiella pneumoniae Isolated from Different Clinical Sources in Al-Najaf Province-Iraq.
The study identified blaSHV, blaTEM, blaCTX-M, qnrB, and aac(6')-Ib-cr genes as the main contributors to multidrug resistance in Klebsiella pneumoniae isolates from burns and urinary tract infections in Iraq.
Extensively Drug-Resistant Escherichia coli Sequence Type 1642 Carrying an IncX3 Plasmid Containing the blaKPC-2 Gene Associated with Transposon Tn4401a.
The study identifies several AMR genes in an extensively drug-resistant E. coli ST1642 isolate, including blaKPC-2, blaSHV-11, blaTEM-1, aadA5, strA, strB, aac(3)-IId, mph(A), sul1, sul2, tet(B), dfrA17, and qnrS1, which contribute to resistance against multiple antibiotics.
Exploring the Genome and Phenotype of Multi-Drug Resistant Klebsiella pneumoniae of Clinical Origin.
The study identified multiple antimicrobial resistance genes in 11 multidrug-resistant Klebsiella pneumoniae isolates, including ESBL genes (blaCTX-M-15, blaSHV-12, blaTEM-1B), fluoroquinolone resistance genes (oqxAB, qnrB), and others such as catA, catB, tet, sul, dfr, and fosA. These genes contribute to resistance against various antibiotics, highlighting the complex resistance profile of these isolates.
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting.
The study identified various AMR genes and mutations in E. coli isolates from children with cystic fibrosis, cancer, and healthy controls, highlighting differences in resistance profiles between groups.
Molecular characterization of beta-lactamase genes in clinical isolates of carbapenem-resistant Acinetobacter baumannii.
The study identified multiple beta-lactamase genes, including bla OXA-23-like, bla OXA-40-like, bla OXA-51-like, bla TEM, bla SHV, bla ampC, and bla ADC-7, in carbapenem-resistant Acinetobacter baumannii isolates. These genes contribute to resistance against carbapenems and other β-lactam antibiotics.
Occurrence of Extended Spectrum β-Lactamases, KPC-Type, and MCR-1.2-Producing Enterobacteriaceae from Wells, River Water, and Wastewater Treatment Plants in Oltrepò Pavese Area, Northern Italy.
The study identified various extended spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-28, and bla CTX-M-138, as well as carbapenemase genes bla KPC-2 and bla KPC-3, and the colistin resistance gene mcr-1.2 in Enterobacteriaceae isolated from water sources in the Oltrepò Pavese area. These genes were found to confer resistance to multiple antibiotics, highlighting the presence of multidrug-resistant bacteria in the environment.
Risk of Transmission of Antimicrobial Resistant Escherichia coli from Commercial Broiler and Free-Range Retail Chicken in India.
The study identified the presence of multidrug-resistant Escherichia coli in retail chicken meat in India, highlighting the risk of transmission of antimicrobial resistance. Key resistance genes included blaCTX-M-15, blaTEM, and blaSHV, which confer resistance to cephalosporins.
Antimicrobial susceptibility and molecular epidemiology of clinical Enterobacter cloacae bloodstream isolates in Shanghai, China.
The study identified several AMR genes in Enterobacter cloacae bloodstream isolates, including ESBLs (SHV-12, CTX-M-15, CTX-M-65), carbapenemases (IMP-26, NDM-1), plasmid-mediated AmpC beta-lactamases (ACT-20, ACT-3, DHA-1), and TEM-1. These genes were associated with resistance to various antibiotics, highlighting the need for continued surveillance.
Different phenotypic and molecular mechanisms associated with multidrug resistance in Gram-negative clinical isolates from Egypt.
The study identified various AMR genes and mutations contributing to multidrug resistance in Gram-negative clinical isolates from Egypt, highlighting the role of efflux pumps and plasmid-mediated quinolone resistance.
Environmental adaptation and vertical dissemination of ESBL-/pAmpC-producing Escherichia coli in an integrated broiler production chain in the absence of an antibiotic treatment.
The study identified blaCMY-2 and blaSHV-12 genes in ESBL-/pAmpC-producing E. coli isolates from broiler production chains, highlighting their role in beta-lactam resistance.
Comparison of antimicrobial resistance genes in feedlots and urban wastewater.
The study identified various antimicrobial resistance genes in feedlots and urban wastewater, highlighting the prevalence of sulfonamide, tetracycline, macrolide, fluoroquinolone, and β-lactam resistance genes in different environments.
The frequency of Klebsiella pneumonia encoding genes for CTX-M, TEM-1 and SHV-1 extended-spectrum beta lactamases enzymes isolated from urinary tract infection.
The study identified the frequency of ESBL-producing K. pneumonia isolates carrying blaSHV-1, blaTEM-1, blaCTX-M-1, blaCTX-M-2, and blaCTX-M-3 genes, with blaSHV-1 being the most prevalent.
Prevalence and characteristics of extended-spectrum beta-lactamase-producing Escherichia coli in domestic and imported chicken meats in Japan.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M, bla TEM, and bla SHV, in Escherichia coli isolates from domestic and imported chicken meats in Japan. The most prevalent ESBL genes were bla CTX-M-2 and bla CTX-M-1 in domestic isolates, while bla CTX-M-2 and bla CTX-M-8 were predominant in imported isolates. The isolates exhibited multidrug resistance.
Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population.
The study identifies clinically relevant ESBL-producing K. pneumoniae ST307 and E. coli ST38 in an urban West African rat population, highlighting the presence of multidrug-resistant strains carrying various resistance genes such as blaCTX-M-15, blaCTX-M-14, blaCTX-M-9, and others.
Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population.
The study identifies clinically relevant ESBL-producing K. pneumoniae ST307 and E. coli ST38 in an urban West African rat population, highlighting the presence of multidrug-resistant strains carrying various resistance genes such as blaCTX-M-15, blaCTX-M-14, blaCTX-M-9, and others.
Genome Sequencing of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in Cameroon.
The study identified multiple antibiotic resistance genes in ESBL-producing K. pneumoniae isolates from pigs and abattoir workers in Cameroon, including bla CTX-M-15, bla TEM-1B, bla SHV-28, and others, highlighting the presence of multidrug-resistant strains and their potential for zoonotic transmission.
Genome Sequencing of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in Cameroon.
The study identified multiple antibiotic resistance genes in ESBL-producing K. pneumoniae isolates from pigs and abattoir workers in Cameroon, including bla CTX-M-15, bla TEM-1B, bla SHV-28, and others, highlighting the presence of multidrug-resistant strains and their potential for zoonotic transmission.
Genome Sequencing of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in Cameroon.
The study identified multiple antibiotic resistance genes in ESBL-producing K. pneumoniae isolates from pigs and abattoir workers in Cameroon, including bla CTX-M-15, bla TEM-1B, bla SHV-28, and others, highlighting the presence of multidrug-resistant strains and their potential for zoonotic transmission.
Genome Sequencing of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in Cameroon.
The study identified multiple antibiotic resistance genes in ESBL-producing K. pneumoniae isolates from pigs and abattoir workers in Cameroon, including bla CTX-M-15, bla TEM-1B, bla SHV-28, and others, highlighting the presence of multidrug-resistant strains and their potential for zoonotic transmission.
Genome Sequencing of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in Cameroon.
The study identified multiple antibiotic resistance genes in ESBL-producing K. pneumoniae isolates from pigs and abattoir workers in Cameroon, including bla CTX-M-15, bla TEM-1B, bla SHV-28, and others, highlighting the presence of multidrug-resistant strains and their potential for zoonotic transmission.
Time to acquire and lose carriership of ESBL/pAmpC producing E. coli in humans in the Netherlands.
The study characterizes the acquisition and loss of carriership of ESBL/pAmpC-producing E. coli, identifying specific genes such as bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla SHV-12, and bla CMY-2 as being involved in resistance to various beta-lactam antibiotics.
Phenotypic and Genomic Characterization of AmpC-Producing Klebsiella pneumoniae From Korea
Phenotypic and Genomic Characterization of AmpC-Producing Klebsiella pneumoniae From Korea
Prediction of Phenotypic Antimicrobial Resistance Profiles From Whole Genome Sequences of Non-typhoidal Salmonella enterica.
The study identified various AMR genes and mutations in non-typhoidal Salmonella enterica, including blaTEM-1, strA-strB, sul2, tet(A), qnrS1, aadA2, aadA17, floR, cmlA1, aac(3)-Id, aac(3)-IIa, dfrA12, dfrA1, dfrA14, blaCTX-M-9, blaCTX-M-55, blaSHV-12, blaPSE-1/blaCARB-2, and blaCMY-2, along with mutations in gyrA and parC associated with ciprofloxacin resistance.
Poultry hatcheries as potential reservoirs for antimicrobial-resistant Escherichia coli: A risk to public health and food safety.
The study identified several beta-lactam resistance genes, including bla TEM, bla SHV, bla OXA-1, bla MOX-like, bla CIT-like, and bla FOX, in Escherichia coli isolates from poultry hatcheries, highlighting the potential of hatcheries as reservoirs of antimicrobial-resistant bacteria.
Typhoid Fever due to Extended Spectrum beta-lactamase-Producing Salmonella enterica Serovar Typhi: A Case Report and Literature Review.
The study identifies the presence of blaTEM, blaSHV, and blaCTX-M genes in an ESBL-producing Salmonella enterica serovar Typhi isolate, contributing to resistance against multiple antibiotics including cephalosporins.
Serotype Diversity and Antimicrobial Resistance among Salmonella enterica Isolates from Patients at an Equine Referral Hospital.
The study identified various AMR genes in Salmonella enterica isolates from equine patients, including beta-lactamases, aminoglycoside modifying enzymes, and genes conferring resistance to tetracyclines, macrolides, and other antibiotics.
Genomic Characterization of Nonclonal mcr-1-Positive Multidrug-Resistant Klebsiella pneumoniae from Clinical Samples in Thailand.
The study identifies mcr-1 as the primary mediator of colistin resistance in two nonclonal multidrug-resistant Klebsiella pneumoniae isolates, QS17-0029 and QS17-0161, which also carry multiple other resistance genes including bla NDM-1, bla OXA-232, bla CTX-M-15, and others.
Virulence determinant and extended spectrum beta-lactamase production in Klebsiella pneumoniae isolated from a tertiary care hospital, South India.
The study identifies blaSHV, blaCTX-M-1, and blaCTX-M-15 as the primary extended-spectrum beta-lactamase (ESBL) genes in K. pneumoniae isolates, highlighting their association with resistance to third-generation cephalosporins.
Extended-spectrum β-lactamase & carbapenemase-producing Gram-negative bacilli in neonates from a tertiary care centre in Dibrugarh, Assam, India.
The study identified several β-lactamase genes, including bla SHV, bla TEM, bla CTX-MU, bla OXA23-like, bla OXA51-like, bla OXA58-like, and bla NDM1, in Gram-negative bacteria isolated from neonates with sepsis in Assam, India.
Genomic and functional characterisation of IncX3 plasmids encoding bla(SHV-12) in Escherichia coli from human and animal origin.
The study identifies and characterizes IncX3 plasmids encoding the bla(SHV-12) gene in Escherichia coli from human and animal origins, highlighting their role in the spread of extended-spectrum beta-lactam resistance.
Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine beta-lactamases.
The study characterizes the antibacterial spectrum of a tetrazole-based reversible inhibitor of serine beta-lactamases, showing significant activity against various CTX-M subtypes and other serine beta-lactamases, including CTX-M-9, CTX-M-14, CTX-M-15, CTX-M-27, SHV-2, KPC-2, AmpC, OXA-48, and TEM-1.
Whole genome sequence revealed the fine transmission map of carbapenem-resistant Klebsiella pneumonia isolates within a nosocomial outbreak.
The study identified the presence of blaKPC-2, blaSHV-1, and blaCTX-M-15 genes in all 26 CRKP isolates, which conferred resistance to multiple beta-lactam antibiotics. The isolates belonged to sequence type ST11 and exhibited a clonal outbreak pattern.
Identification and antimicrobial susceptibility of microorganisms isolated from severe corneal ulcers of dogs in Thailand.
The study identified methicillin-resistant Staphylococcus spp. carrying the mecA gene, and ESBL-producing isolates with bla CTX-M, bla VEB-1, and bla SHV genes. Staphylococci showed high resistance to fluoroquinolones and fusidic acid, while chloramphenicol remained effective against methicillin-resistant strains.
Prevalence of extended spectrum beta lactamase and plasmid mediated quinolone resistant genes in strains of Klebsiella pneumonia, Morganella morganii, Leclercia adecarboxylata and Citrobacter freundii isolated from poultry in South Western Nigeria.
The study identified the presence of ESBL genes (SHV, TEM, CTX-M) and PMQR genes (qnrA, qnrB, qepA, oqxB) in Klebsiella pneumonia, Morganella morganii, Leclercia adecarboxylata, and Citrobacter freundii isolated from poultry in South Western Nigeria.
Antimicrobial resistance, biofilm synthesis and virulence genes in Salmonella isolated from pigs bred on intensive farms.
The study identified multidrug-resistant Salmonella isolates from pigs, showing resistance to multiple antibiotics including colistin, ciprofloxacin, and others. No ESBL-producing isolates were found, but several virulence genes were detected.
Past and Present Perspectives on beta-lactamases
The paper discusses the evolution and classification of beta-lactamases, highlighting their role in antibiotic resistance and the emergence of new variants such as TEM-1, SHV-1, OXA-1, and AmpC.
Molecular characterization of extended spectrum β -lactamases enterobacteriaceae causing lower urinary tract infection among pediatric population.
The study identified bla CTX-MG1, bla CTX-MG9, bla CTX-MG2, bla CTX-MG8, bla TEM, and bla SHV as the main genes responsible for extended-spectrum beta-lactamase (ESBL) resistance in Enterobacteriaceae causing urinary tract infections in pediatric populations in Qatar.
Superficieibacter electus gen. nov., sp. nov., an Extended-Spectrum β-Lactamase Possessing Member of the Enterobacteriaceae Family, Isolated From Intensive Care Unit Surfaces.
The study identifies multiple antibiotic resistance genes in the newly described species Superficieibacter electus, including beta-lactamases, aminoglycoside modifying enzymes, and others, indicating its ability to resist various antibiotics.
Extended-spectrum beta-lactamase-encoding genes are spreading on a wide range of Escherichia coli plasmids existing prior to the use of third-generation cephalosporins.
The study identifies various extended-spectrum beta-lactamase (ESBL)-encoding genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-9, bla CTX-M-3, bla CTX-M-2, bla SHV-12, bla SHV-2, bla SHV-5, bla SHV-3, bla TEM-52, bla TEM-24, bla TEM-21, and bla TEM-3, which are found on a wide range of Escherichia coli plasmids. These genes are responsible for resistance to various β-lactam antibiotics.
Extended-spectrum beta-lactamase-encoding genes are spreading on a wide range of Escherichia coli plasmids existing prior to the use of third-generation cephalosporins.
The study identifies various extended-spectrum beta-lactamase (ESBL)-encoding genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-9, bla CTX-M-3, bla CTX-M-2, bla SHV-12, bla SHV-2, bla SHV-5, bla SHV-3, bla TEM-52, bla TEM-24, bla TEM-21, and bla TEM-3, which are found on a wide range of Escherichia coli plasmids. These genes are responsible for resistance to various β-lactam antibiotics.
Extended-spectrum beta-lactamase-encoding genes are spreading on a wide range of Escherichia coli plasmids existing prior to the use of third-generation cephalosporins.
The study identifies various extended-spectrum beta-lactamase (ESBL)-encoding genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-9, bla CTX-M-3, bla CTX-M-2, bla SHV-12, bla SHV-2, bla SHV-5, bla SHV-3, bla TEM-52, bla TEM-24, bla TEM-21, and bla TEM-3, which are found on a wide range of Escherichia coli plasmids. These genes are responsible for resistance to various β-lactam antibiotics.
Extended-spectrum beta-lactamase-encoding genes are spreading on a wide range of Escherichia coli plasmids existing prior to the use of third-generation cephalosporins.
The study identifies various extended-spectrum beta-lactamase (ESBL)-encoding genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-9, bla CTX-M-3, bla CTX-M-2, bla SHV-12, bla SHV-2, bla SHV-5, bla SHV-3, bla TEM-52, bla TEM-24, bla TEM-21, and bla TEM-3, which are found on a wide range of Escherichia coli plasmids. These genes are responsible for resistance to various β-lactam antibiotics.
Molecular Characterization of Extended-Spectrum β-Lactamase-Producing Multidrug Resistant Escherichia coli From Swine in Northwest China.
The study identified multiple β-lactamase genes, including bla CTX-M, bla TEM, bla SHV, bla OXA-48, and bla KPC-2, as well as PMQR genes such as qnrS and aac(6')-Ib-cr, in multidrug-resistant E. coli isolates from swine in Northwest China.
Molecular characterization and epidemiology of carbapenem non-susceptible Enterobacteriaceae isolated from the Eastern region of Heilongjiang Province, China.
The study identified bla KPC-2, bla NDM, bla SHV, bla TEM, and bla CTX-M-15 as the main drug resistance genes in carbapenem non-susceptible Enterobacteriaceae (CNSE) isolates from the Eastern region of Heilongjiang Province, China. The primary resistance mechanism was the production of carbapenemases and extended-spectrum beta-lactamases.
Characterization of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae From Retail Food in China.
The study identified blaTEM, blaCTX-M, blaSHV, and blaOXA genes as the main contributors to extended-spectrum beta-lactamase (ESBL) production in Enterobacteriaceae isolated from retail foods in China. These genes were found to confer resistance to multiple antibiotics, highlighting the significance of these resistance mechanisms in food-borne pathogens.
Extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) isolated from bean sprouts in the Netherlands.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-14, blaCTX-M-3, blaCTX-M-15, blaCTX-M-27, blaSHV-2, blaSHV-27, and blaSHV-99, in ESBL-producing Enterobacteriaceae isolated from bean sprouts in the Netherlands. These genes were found to confer resistance to beta-lactam antibiotics.
Extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) isolated from bean sprouts in the Netherlands.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-14, blaCTX-M-3, blaCTX-M-15, blaCTX-M-27, blaSHV-2, blaSHV-27, and blaSHV-99, in ESBL-producing Enterobacteriaceae isolated from bean sprouts in the Netherlands. These genes were found to confer resistance to beta-lactam antibiotics.
Extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) isolated from bean sprouts in the Netherlands.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-14, blaCTX-M-3, blaCTX-M-15, blaCTX-M-27, blaSHV-2, blaSHV-27, and blaSHV-99, in ESBL-producing Enterobacteriaceae isolated from bean sprouts in the Netherlands. These genes were found to confer resistance to beta-lactam antibiotics.
Off-label use of ceftiofur in one-day chicks triggers a short-term increase of ESBL-producing E. coli in the gut.
The study found that off-label use of ceftiofur in one-day chicks led to a short-term increase in ESBL-producing E. coli, primarily carrying bla CTX-M and bla SHV genes.
Molecular characteristics of extended-spectrum β-lactamase-producing Escherichia coli isolated from the rivers and lakes in Northwest China.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-14, bla CTX-M-9, bla CTX-M-123, bla CTX-M-15, bla CTX-M-27, bla CTX-M-1, and bla CTX-M-65, as well as bla TEM-1 and bla SHV-12. Additionally, the PMQR gene aac(6′)-Ib-cr was found to be the most prevalent. These genes were associated with resistance to various beta-lactam and aminoglycoside antibiotics.
Superintendence of antimicrobial resistance observed in bacterial flora isolated from human faecal carriage in Vellore, India.
The study identified the presence of ESBL genes such as blaCTX-M, blaTEM, and blaSHV in Enterobacteriaceae and Pseudomonas aeruginosa isolates from faecal samples, indicating significant antimicrobial resistance.
High frequency and molecular epidemiology of metallo-β-lactamase-producing gram-negative bacilli in a tertiary care hospital in Lahore, Pakistan.
The study identified the prevalence of metallo-beta-lactamase (MBL)-producing gram-negative bacilli in a tertiary care hospital in Lahore, Pakistan. It found that bla TEM, bla SHV, bla OXA, bla IMP-1, and bla VIM genes were frequently present in imipenem-resistant isolates, indicating the coexistence of extended-spectrum beta-lactamase (ESBL) and MBL genes.
Analysis of bacteriological pollution and the detection of antibiotic resistance genes of prevailing bacteria emanating from pig farm seepage.
The study identified several antibiotic resistance genes in bacteria isolated from pig farm seepage, including aadA, aa(6')-le-aph(2")-la, aph(2")-lb, aph(2")-lc, aph(2")-ld, aph(3")-llla, ant(4')-la, VanA, VanB, VanC2/C3, InuA, InuB, InuC, InuF, blaTEM, blaSHV, blaOXA, OtrA, OtrB, Sul1, and Sul2. These genes conferred resistance to various antibiotics such as penicillins, sulfamethoxazole, tetracyclines, and glycopeptides.
Antibiotic-Resistant Bacteria in Greywater and Greywater-Irrigated Soils.
The study identified tetracycline-resistant bacteria in treated greywater and greywater-irrigated soils, with tet39 being the most prevalent tetracycline resistance gene. Several beta-lactamase genes, including blaTEM, blaCTXM-32, blaOXA-2, and blaOXA-10, were also detected, indicating multidrug resistance.
The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis.
The study characterized the resistomes of six carbapenem-resistant pathogens, identifying various carbapenemase genes such as bla KPC-2, bla OXA-48, bla OXA-72, bla NDM-1, bla NDM-7, and bla VIM-1, along with other resistance genes like aac(6')-Ib-cr, aph(3")-Ib, aph(6)-Id, tet(B), erm(B), mph(A), sul1, sul2, dfrA17, dfrA14, bla CTX-M-15, bla CMY-6, bla OXA-1, bla SHV-200, bla OXA-10, and bla NDM-7.
The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis.
The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis.
The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis.
Characterization of Gene Families Encoding Beta-Lactamases of Gram-Negative Rods Isolated from Ready-to-Eat Vegetables in Mexico City.
The study identified various beta-lactamase genes, including blaBIL, blaSHV, blaCTX, blaDHA, blaVIM, blaOXA, blaIMP, blaKPC, and blaTEM, which confer resistance to beta-lactam antibiotics in Enterobacteriaceae isolated from ready-to-eat vegetables in Mexico City.
Co-production of AmpC and extended spectrum beta-lactamases in cephalosporin-resistant Acinetobacter baumannii in Egypt.
The study identifies the prevalence of extended-spectrum beta-lactamases (ESBLs) and AmpC beta-lactamases in cephalosporin-resistant Acinetobacter baumannii isolates in Egypt, highlighting the co-production of blaTEM, blaPER, blaSHV, blaVEB, and blaADC genes contributing to beta-lactam resistance.
Study of class 1 integrons in multidrug-resistant uropathogenic Escherichia coli isolated from different hospitals in Karachi.
The study identified CTX-M1, TEM, and SHV as the predominant ESBL genes in MDR uropathogenic E. coli, along with class 1 integrons carrying intI1, qacEΔ1, and sul1.
Zoonotic multidrug-resistant microorganisms among small companion animals in Germany.
The study identified ESBL-producing Enterobacteriaceae and MRSA in companion animals, highlighting the presence of beta-lactam resistance genes such as bla TEM, bla CTX-M, bla SHV, and bla CMY-2, as well as methicillin resistance genes mecA and mecC in various staphylococcal species.
Whole genome sequence analysis of NDM-1, CMY-4, and SHV-12 coproducing Salmonella enterica serovar Typhimurium isolated from a case of fatal burn wound infection.
The study reports the first case of a carbapenem-resistant and MBL (NDM-1), ESBL (SHV-12), and AmpC beta-lactamase (CMY-4) coproducing Salmonella Typhimurium isolated from a fatal burn wound infection.
Alarming levels of antimicrobial resistance among sepsis patients admitted to ICU in a tertiary care hospital in India - a case control retrospective study.
The study identified high levels of antimicrobial resistance in E. coli isolates from sepsis patients in an Indian ICU, with a significant prevalence of ESBL genes including CTX-M15, CTX-M9, TEM, SHV, and OXA-1.
Epidemiology of Bloodstream Infections Caused by Escherichia coli and Klebsiella pneumoniae That Are Piperacillin-Tazobactam-Nonsusceptible but Ceftriaxone-Susceptible.
The study identified bla TEM-1, bla SHV-1, and bla OXA-1 as the primary beta-lactamase genes responsible for piperacillin-tazobactam non-susceptibility in Escherichia coli and Klebsiella pneumoniae isolates, without the presence of ESBLs, AmpC-beta-lactamases, or carbapenemases.
Prevalence, risk factors, and characterization of multidrug resistant and extended spectrum β-lactamase/AmpC β-lactamase producing Escherichia coli in healthy horses in France in 2015.
The study identified bla CTX-M-1, bla CTX-M-2, bla CTX-M-14, bla SHV-12, and bla CMY-2 as the primary beta-lactamase genes responsible for extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase production in Escherichia coli isolates from healthy horses in France. These genes conferred resistance to various beta-lactam antibiotics, including ceftiofur, ceftriaxone, and cefoxitin.
Antibiotic collateral sensitivity is contingent on the repeatability of evolution.
The study identifies SHV-1 beta-lactamase mutations (G242S, G238C, G238A, G238S) as key drivers of cefotaxime resistance in E. coli, demonstrating heterogeneous collateral responses to second-line antibiotics based on evolutionary trajectories.
Molecular Characterization of Carbapenem Resistant Klebsiella pneumoniae and Klebsiella quasipneumoniae Isolated from Lebanon.
The study identified several carbapenemase genes, including bla OXA-48, bla NDM-1, bla NDM-7, and bla CTX-M-15, as well as the chromosomally-encoded beta-lactamase bla OKP-B-3, in carbapenem-resistant Klebsiella pneumoniae and Klebsiella quasipneumoniae isolates from Lebanon.
Co-outbreak of multidrug resistance and a novel ST3006 Klebsiella pneumoniae in a neonatal intensive care unit: A retrospective study.
The study identified two clones of multidrug-resistant Klebsiella pneumoniae, ST37 and ST3006, in a neonatal intensive care unit. ST37 harbored multiple resistance genes, including OXA-33, TEM-1, SHV-11, and others, while ST3006 carried fewer resistance genes. Whole-genome sequencing revealed the presence of various antibiotic resistance genes and genomic islands.
High Prevalence of Multidrug-Resistant Klebsiella pneumoniae Harboring Several Virulence and beta-lactamase Encoding Genes in a Brazilian Intensive Care Unit.
The study identified a high prevalence of multidrug-resistant Klebsiella pneumoniae isolates carrying various beta-lactamase genes (bla KPC, bla TEM, bla SHV, bla OXA-1, and bla CTX-M-1) and efflux pump genes (AcrAB, tol C, mdt K) along with outer membrane porin genes (Omp K35 and Omp K36).
Circulation of Plasmids Harboring Resistance Genes to Quinolones and/or Extended-Spectrum Cephalosporins in Multiple Salmonella enterica Serotypes from Swine in the United States.
The study identifies multiple plasmid-mediated resistance genes in Salmonella enterica serotypes from swine in the United States, including qnrB19, qnrB2, qnrB15, qnrD, qnrS1, qnrS2, aac(6')-Ib-cr, bla CMY-2, bla CTX-M-1, bla CTX-M-27, and bla SHV-12, which confer resistance to quinolones and extended-spectrum cephalosporins.
Diversity of Plasmids and Genes Encoding Resistance to Extended Spectrum Cephalosporins in Commensal Escherichia coli From Dutch Livestock in 2007-2017.
The study identified 22 different ESBL/pAmpC genes in commensal E. coli from Dutch livestock, with bla CTX-M-1 being the most prevalent. Other notable genes included bla CMY-2, bla TEM-52, bla SHV-12, and bla CTX-M-15. The study also highlighted the role of plasmids in the dissemination of these resistance genes.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Prevalence of Extended-Spectrum-β-Lactamase-Producing Escherichia coli in Imported Frozen Freshwater Fish in Eastern Province of Saudi Arabia.
The study found that 27.2% of imported frozen freshwater fish samples in Saudi Arabia contained ESBL-producing E. coli, with bla CTX-M being the most prevalent ESBL gene, followed by bla SHV and bla TEM.
A One Health Study of the Genetic Relatedness of Klebsiella pneumoniae and Their Mobile Elements in the East of England.
Transcriptome analysis of beta-lactamase genes in diarrheagenic Escherichia coli.
Multi-state study of Enterobacteriaceae harboring extended-spectrum beta-lactamase and carbapenemase genes in U.S. drinking water.
The study identified bla CTX-M, bla SHV, bla TEM, and bla OXA-48 genes in coliform-positive drinking water samples across six U.S. states, highlighting the presence of extended-spectrum beta-lactamase and carbapenemase genes in non-Enterobacteriaceae species, indicating potential community exposure risks.
Detection of critical antibiotic resistance genes through routine microbiome surveillance.
The study identifies various antibiotic resistance genes (ARGs) associated with multidrug resistance, including macrolide, beta-lactam, tetracycline, and methicillin resistance genes, highlighting the presence of these genes in postmortem microbiome samples.
Extended Spectrum Beta-Lactamase-Producing Gram-Negative Bacteria Recovered From an Amazonian Lake Near the City of Belém, Brazil.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-2, bla TEM, and bla SHV, in multidrug-resistant gram-negative bacteria from an Amazonian lake. These genes were associated with resistance to cephalosporins and other beta-lactam antibiotics.
High prevalence of CTX-M-1 group in ESBL-producing enterobacteriaceae infection in intensive care units in southern Chile.
The study identified a high prevalence of CTX-M-1 group beta-lactamases in ESBL-producing enterobacteriaceae in intensive care units in southern Chile, highlighting the significance of these enzymes in the epidemiology of antimicrobial resistance.
Despite Predominance of Uropathogenic/Extraintestinal Pathotypes Among Travel-acquired Extended-spectrum beta-lactamase-producing Escherichia coli, the Most Commonly Associated Clinical Manifestation Is Travelers' Diarrhea.
The study identifies various beta-lactamase genes (TEM, OXA, SHV, CTX-M group 1, and CTX-M group 9) in travel-acquired ESBL-producing E. coli strains, highlighting their role in resistance to multiple β-lactam antibiotics. The most common clinical manifestation associated with these strains was travelers' diarrhea rather than urinary tract infections.
Antibiotic Susceptibility Patterns and Prevalence of Some Extended Spectrum Beta-Lactamases Genes in Gram-Negative Bacteria Isolated from Patients Infected with Urinary Tract Infections in Al-Najaf City, Iraq.
The study identified the prevalence of blaTEM, blaSHV, and blaCTX-M genes in gram-negative bacteria isolated from urinary tract infections in patients with chronic kidney disease (CKD) in Al-Najaf City, Iraq. These genes were more commonly detected in CKD patients compared to those without kidney disease (WKD).
Identification of a Carbapenemase-Producing Hypervirulent Klebsiella pneumoniae Isolate in the United States.
The study identifies a carbapenemase-producing hypervirulent Klebsiella pneumoniae isolate (CP-hvKP) in the United States, which carries the blaKPC-2 gene on a plasmid, along with other resistance genes such as blaSHV-36, fosA, oqxA, and oqxB. The isolate also possesses hypervirulence factors, highlighting the dual threat of antimicrobial resistance and virulence.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
Identification of Escherichia coli from broiler chickens in Jordan, their antimicrobial resistance, gene characterization and the associated risk factors.
The study identified several antimicrobial resistance genes in Escherichia coli isolates from broiler chickens in Jordan, including tetA, tetB, int1, sul1, sul2, blaTEM, and cat. These genes were associated with resistance to various antibiotics such as tetracycline, sulfonamides, beta-lactams, and chloramphenicol.
Characterization of a carbapenem- and colistin-resistant Enterobacter cloacae carrying Tn6901 in bla (NDM-1) genomic context.
The study characterizes a carbapenem- and colistin-resistant Enterobacter cloacae strain, PIMB10EC27, which carries multiple resistance genes including blaNDM-1, blaSHV-12, and qnrS1, as well as mutations in pmrB and pmrC that may contribute to colistin resistance.
Infection caused by Klebsiella pneumoniae ST11 in a patient after craniectomy.
The study identifies blaSHV-11, blaTEM-1, blaCTX-M-15, and blaKPC-3 genes in multidrug-resistant K. pneumoniae ST11 isolates from a neurosurgical patient, highlighting their role in resistance to beta-lactam and carbapenem antibiotics.
Evaluation of the Synergy of Ceftazidime-Avibactam in Combination with Meropenem, Amikacin, Aztreonam, Colistin, or Fosfomycin against Well-Characterized Multidrug-Resistant Klebsiella pneumoniae and Pseudomonas aeruginosa.
The study evaluated the synergy of ceftazidime-avibactam (CZA) in combination with other antibiotics against multidrug-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa. Several AMR genes, including blaKPC-2, blaKPC-3, blaCTX-M-15, and others, were identified as conferring resistance to CZA and other antibiotics.
Molecular detection of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates of chicken origin from East Java, Indonesia.
The study identified the presence of ESBL genes (bla TEM, bla CTX-M, and bla SHV) in K. pneumoniae isolates from chicken farms in East Java, Indonesia, indicating multidrug resistance.
Phenotypic and genotypic characterization of multi-drug-resistant Escherichia coli isolates harboring bla(CTX-M) group extended-spectrum beta-lactamases recovered from pediatric patients in Shenzhen, southern China.
The study identified various bla CTX-M subtypes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-90, and others, as well as bla TEM, bla SHV, bla GES, bla CARB, bla NDM-1, bla KPC, and mcr-1, which contribute to multidrug resistance in E. coli isolates from pediatric patients in Shenzhen, China.
Establishing Antimicrobial Resistance Surveillance & Research Network in India: Journey so far.
The study characterizes various AMR genes and mutations in different bacterial pathogens, highlighting the prevalence of resistance to multiple antibiotics, including beta-lactams, fluoroquinolones, and aminoglycosides. Key findings include the widespread presence of bla OXA-48, bla TEM, and qnrS1 in Enterobacteriaceae, and mecA, mupA, cfr, and ermC in Staphylococcus aureus.
Metal impacts on the persistence and proliferation of β-lactam resistance genes in Xiangjiang River, China.
The study identifies and characterizes the persistence and proliferation of various β-lactam resistance genes (blaTEM, blaVIM, blaSHV, blaGES, blaDHA, blaOXA-1, blaOXA-2, blaOXA-10, blaCMY-2, and blaampC) in the Xiangjiang River, highlighting the impact of heavy metals on their distribution and the role of bacterial communities in their persistence.
Carriage of carbapenemase- and extended-spectrum cephalosporinase-producing Escherichia coli and Klebsiella pneumoniae in humans and livestock in rural Cambodia; gender and age differences and detection of bla(OXA-48) in humans.
The study identified various beta-lactamase genes such as bla CTX-M27, bla CTX-M55, bla CTX-M15, bla CTX-M14, bla CMY-2, bla CMY-42, bla SHV-2, bla SHV-12, bla SHV-28, bla SHV-1, bla DHA-1, and bla OXA-48, along with colistin resistance genes mcr-1-like and mcr-3-like in Escherichia coli and Klebsiella pneumoniae isolates from humans and livestock in Cambodia.
Carriage of carbapenemase- and extended-spectrum cephalosporinase-producing Escherichia coli and Klebsiella pneumoniae in humans and livestock in rural Cambodia; gender and age differences and detection of bla(OXA-48) in humans.
The study identified various beta-lactamase genes such as bla CTX-M27, bla CTX-M55, bla CTX-M15, bla CTX-M14, bla CMY-2, bla CMY-42, bla SHV-2, bla SHV-12, bla SHV-28, bla SHV-1, bla DHA-1, and bla OXA-48, along with colistin resistance genes mcr-1-like and mcr-3-like in Escherichia coli and Klebsiella pneumoniae isolates from humans and livestock in Cambodia.
Carriage of carbapenemase- and extended-spectrum cephalosporinase-producing Escherichia coli and Klebsiella pneumoniae in humans and livestock in rural Cambodia; gender and age differences and detection of bla(OXA-48) in humans.
The study identified various beta-lactamase genes such as bla CTX-M27, bla CTX-M55, bla CTX-M15, bla CTX-M14, bla CMY-2, bla CMY-42, bla SHV-2, bla SHV-12, bla SHV-28, bla SHV-1, bla DHA-1, and bla OXA-48, along with colistin resistance genes mcr-1-like and mcr-3-like in Escherichia coli and Klebsiella pneumoniae isolates from humans and livestock in Cambodia.
Carriage of carbapenemase- and extended-spectrum cephalosporinase-producing Escherichia coli and Klebsiella pneumoniae in humans and livestock in rural Cambodia; gender and age differences and detection of bla(OXA-48) in humans.
The study identified various beta-lactamase genes such as bla CTX-M27, bla CTX-M55, bla CTX-M15, bla CTX-M14, bla CMY-2, bla CMY-42, bla SHV-2, bla SHV-12, bla SHV-28, bla SHV-1, bla DHA-1, and bla OXA-48, along with colistin resistance genes mcr-1-like and mcr-3-like in Escherichia coli and Klebsiella pneumoniae isolates from humans and livestock in Cambodia.
Carriage of carbapenemase- and extended-spectrum cephalosporinase-producing Escherichia coli and Klebsiella pneumoniae in humans and livestock in rural Cambodia; gender and age differences and detection of bla(OXA-48) in humans.
The study identified various beta-lactamase genes such as bla CTX-M27, bla CTX-M55, bla CTX-M15, bla CTX-M14, bla CMY-2, bla CMY-42, bla SHV-2, bla SHV-12, bla SHV-28, bla SHV-1, bla DHA-1, and bla OXA-48, along with colistin resistance genes mcr-1-like and mcr-3-like in Escherichia coli and Klebsiella pneumoniae isolates from humans and livestock in Cambodia.
Commonality of Multidrug-Resistant Klebsiella pneumoniae ST348 Isolates in Horses and Humans in Portugal.
Molecular Epidemiology of Multidrug-Resistant Klebsiella pneumoniae Isolates in a Brazilian Tertiary Hospital.
The study identified various AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae isolates, including bla KPC, bla CTX-M, bla TEM, and mutations in ompk35, ompk36, gyrA, and parC. These findings highlight the complex resistance mechanisms contributing to the persistence of MDR-Kp in the hospital setting.
Extended-Spectrum Beta-Lactamase-production in Escherichia coli isolated from door handles in Nasarawa State University, Keffi, Nigeria.
The study identified blaTEM and blaSHV genes as the primary extended-spectrum beta-lactamase (ESBL) genes in E. coli isolates from door handles in Nasarawa State University, Keffi, Nigeria. blaCTX-M was not detected in any of the isolates.
Multilocus sequence typing and bla (ESBL) characterization of extended-spectrum beta-lactamase-producing Escherichia coli isolated from healthy humans and swine in Northern Thailand.
The study identified bla CTX-M, bla TEM, and bla SHV as the primary ESBL genes in ESBL-producing E. coli isolates from healthy humans and swine in Northern Thailand. Additionally, several other AMR genes such as sul1, sul2, sul3, aadA22, aph(3')-Ia, strA, strB, aadA2, aadA5, qnrS1, tetA, tetB, tetD, arr2, and mefB were characterized.
Evolution of Outbreak-Causing Carbapenem-Resistant Klebsiella pneumoniae ST258 at a Tertiary Care Hospital over 8 Years.
The study identifies various AMR genes in ST258 K. pneumoniae isolates, including blaKPC-2, blaKPC-3, aadA2, aadA1, blaTEM-1A, blaSHV-11, blaSHV-12, oqxA, oqxB, fosA, dfrA12, dfrA14, sul1, sul2, catA1, cml, and strAB, which confer resistance to multiple antibiotics.
Evolution of Outbreak-Causing Carbapenem-Resistant Klebsiella pneumoniae ST258 at a Tertiary Care Hospital over 8 Years.
The study identifies various AMR genes in ST258 K. pneumoniae isolates, including blaKPC-2, blaKPC-3, aadA2, aadA1, blaTEM-1A, blaSHV-11, blaSHV-12, oqxA, oqxB, fosA, dfrA12, dfrA14, sul1, sul2, catA1, cml, and strAB, which confer resistance to multiple antibiotics.
Detection of multidrug resistance and extended-spectrum/plasmid-mediated AmpC beta-lactamase genes in Enterobacteriaceae isolates from diseased cats in Italy.
The study identified various beta-lactamase genes, including CTX-M-1, CTX-M-2, CTX-M-9, CTX-M-79, SHV-12, TEM-92, and CMY-2, which confer resistance to third-generation cephalosporins in Enterobacteriaceae isolates from diseased cats in Italy.
Characterization of a Carbapenem-Resistant Kluyvera Cryocrescens Isolate Carrying Bla(ndm-1) from Hospital Sewage.
The study characterizes a carbapenem-resistant Kluyvera cryocrescens isolate carrying blaNDM-1 on a self-transmissible IncX3 plasmid, along with other resistance genes such as blaSHV-12, blaCTX-M-3, qnrS1, sul1, fosA, dfrA21, and dfrA14.
An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation.
The study identifies an extensively drug-resistant (XDR) sublineage II.1 of Salmonella Typhimurium ST313 in the Democratic Republic of the Congo, carrying resistance genes such as catA, blaTEM1, dfrA, blaSHV-2A, mphA, qnrS, and gyrA mutations, along with an IncHI2 plasmid pSTm-ST313-II.1.
Prevalence of Beta-Lactam and Quinolone/Fluoroquinolone Resistance in Enterobacteriaceae From Dogs in France and Spain-Characterization of ESBL/pAmpC Isolates, Genes, and Conjugative Plasmids.
The study identified several beta-lactam resistance genes, including bla CTX-M-1, bla CTX-M-15, bla SHV-12, and bla CMY-2, in Enterobacteriaceae from dogs in France and Spain. These genes were associated with resistance to cefotaxime and were carried on various conjugative plasmids.
Antibiotic-Induced, Increased Conjugative Transfer Is Common to Diverse Naturally Occurring ESBL Plasmids in Escherichia coli.
The study shows that antibiotic exposure increases conjugative transfer of various ESBL plasmids in E. coli, highlighting the potential risk of antibiotic use in promoting the spread of antibiotic resistance.
Occurrence of and risk factors for extended-spectrum cephalosporin-resistant Enterobacteriaceae determined by sampling of all Norwegian broiler flocks during a six month period.
The study identified bla CMY, bla CTX-M-1, bla CTX-M-15, and bla SHV-12 as the primary resistance genes in extended-spectrum cephalosporin-resistant Enterobacteriaceae from Norwegian broiler flocks.
First Detection of Carbapenem-Resistant Escherichia fergusonii Strains Harbouring Beta-Lactamase Genes from Clinical Samples.
Three carbapenem-resistant Escherichia fergusonii isolates (CR11, CR35, and CR49) were identified, harboring CTX-M, TEM, and SHV beta-lactamase genes, leading to resistance against various beta-lactam antibiotics.
High rate of multiresistant Klebsiella pneumoniae from human and animal origin.
The study identified multiple AMR genes, including blaKPC, blaNDM, blaTEM, blaSHV, qnrA, and tolC, in Klebsiella pneumoniae isolates from humans and animals in Henan, China. These genes were associated with resistance to various antibiotics, highlighting the prevalence of multidrug-resistant strains.
Preliminary survey of extended-spectrum beta-lactamases (ESBLs) in nosocomial uropathogen Klebsiella pneumoniae in north-central Iran.
The study identified the presence of bla TEM, bla CTX-M, and bla SHV genes in ESBL-producing K. pneumoniae isolates, highlighting the high prevalence of these genes in the region.
Molecular characterization of carbapenem-resistant Klebsiella pneumoniae isolates with focus on antimicrobial resistance.
The study identifies blaKPC-2 as the dominant carbapenemase gene in clinical CRKP isolates, along with various ESBLs and other resistance genes such as blaCTX-M, blaTEM, blaSHV, aac(3)-IId, rmtB, QnrS1, oqxA, oqxB, fosA, catA1, catA2, dfrA1, and dfrA17.
Molecular characterization of carbapenem-resistant Klebsiella pneumoniae isolates with focus on antimicrobial resistance.
The study identifies blaKPC-2 as the dominant carbapenemase gene in clinical CRKP isolates, along with various ESBLs and other resistance genes such as blaCTX-M, blaTEM, blaSHV, aac(3)-IId, rmtB, QnrS1, oqxA, oqxB, fosA, catA1, catA2, dfrA1, and dfrA17.
Household cockroaches carry CTX-M-15-, OXA-48- and NDM-1-producing enterobacteria, and share beta-lactam resistance determinants with humans.
The study identified CTX-M-15, OXA-48, and NDM-1 beta-lactamase genes in enterobacteria from household cockroaches and human fecal samples, highlighting the potential for these pests to serve as reservoirs of antibiotic resistance genes.
Household cockroaches carry CTX-M-15-, OXA-48- and NDM-1-producing enterobacteria, and share beta-lactam resistance determinants with humans.
The study identified CTX-M-15, OXA-48, and NDM-1 beta-lactamase genes in enterobacteria from household cockroaches and human fecal samples, highlighting the potential for these pests to serve as reservoirs of antibiotic resistance genes.
Genomic characterization of an emerging bla(KPC-2) carrying Enterobacteriaceae clinical isolates in Thailand.
The study describes the first characterization of blaKPC-2 carrying Klebsiella pneumoniae, Escherichia coli, and Enterobacter asburiae isolates in Thailand, highlighting their resistance to carbapenems and other antibiotics.
First Reported Nosocomial Outbreak Of NDM-5-Producing Klebsiella pneumoniae In A Neonatal Unit In China.
The study describes the first reported nosocomial outbreak of NDM-5-producing Klebsiella pneumoniae in a neonatal unit in China, highlighting the presence of bla NDM-5, bla SHV-11, and bla TEM-1 genes conferring resistance to multiple beta-lactam antibiotics.
Raw meat-based diets for companion animals: a potential source of transmission of pathogenic and antimicrobial-resistant Enterobacteriaceae.
The study identified several AMR genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-3, bla CTX-M-9, bla SHV-12, mcr-1, and rmtB, in Enterobacteriaceae isolated from raw meat-based diets for companion animals. These genes confer resistance to various antibiotics, highlighting the potential public health risk associated with the consumption of such diets.
Molecular detection and antibiotic resistance pattern of extended-spectrum beta-lactamase producing Escherichia coli in a Tertiary Hospital in Enugu, Nigeria.
The study identified bla CTX-M, bla TEM, and bla SHV genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) production in E. coli isolates from a Nigerian hospital. These genes were detected in 35% of the E. coli isolates, with bla CTX-M being the most prevalent.
Rapid MinION profiling of preterm microbiota and antimicrobial-resistant pathogens.
The study demonstrates the capability of MinION sequencing combined with NanoOK RT software to rapidly identify pathogens and their antimicrobial resistance gene profiles in preterm infants, enabling real-time diagnostics and resistance profiling.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Genotypic validation of extended-spectrum beta-lactamase and virulence factors in multidrug resistance Klebsiella pneumoniae in an Indian hospital.
The study identified blaTEM, blaSHV, and blaCTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) production in multidrug-resistant Klebsiella pneumoniae isolates. Additionally, virulence factors such as fimH-1, mrkD, entB, irp-1, K1, and K2 were found to be prevalent among the isolates.
VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-beta-lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa.
Taniborbactam is a broad-spectrum beta-lactamase inhibitor that restores the activity of cefepime against Enterobacterales and Pseudomonas aeruginosa producing various beta-lactamases, including serine and metallo-beta-lactamases.
The Occurrence and Characterization of Extended-Spectrum-Beta-Lactamase-Producing Escherichia coli Isolated from Clinical Diagnostic Specimens of Equine Origin.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including a novel TEM-1-type gene, bla TEM-233, in Escherichia coli isolates from equine clinical specimens. It also detected bla SHV-12, bla CTX-M-1, bla OXA-1, and bla IMP-1, highlighting the presence of multidrug-resistant E. coli in equine populations.
Decreasing prevalence of contamination with extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in retail chicken meat in the Netherlands.
The study identified several ESBL genes, including bla CTX-M-1, bla SHV-12, and others, in ESBL-E isolates from retail chicken meat in the Netherlands. The prevalence of ESBL-E decreased over time, and there were variations in prevalence among different supermarket chains and farming methods.
Decreasing prevalence of contamination with extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in retail chicken meat in the Netherlands.
The study identified several ESBL genes, including bla CTX-M-1, bla SHV-12, and others, in ESBL-E isolates from retail chicken meat in the Netherlands. The prevalence of ESBL-E decreased over time, and there were variations in prevalence among different supermarket chains and farming methods.
Decreasing prevalence of contamination with extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in retail chicken meat in the Netherlands.
The study identified several ESBL genes, including bla CTX-M-1, bla SHV-12, and others, in ESBL-E isolates from retail chicken meat in the Netherlands. The prevalence of ESBL-E decreased over time, and there were variations in prevalence among different supermarket chains and farming methods.
Antimicrobial Resistance Factors of Extended-Spectrum Beta-Lactamases Producing Escherichia coli and Klebsiella pneumoniae Isolated from Cattle Farms and Raw Beef in North-West Province, South Africa.
The study identified ESBL genes including blaTEM, blaSHV, blaCTX-M, and blaOXA in E. coli and K. pneumoniae isolates from cattle feces and raw beef, highlighting the presence of multidrug-resistant strains in the food chain.
Molecular-diversity, Prevalence and Antibiotic Susceptibility of Pathogenic Klebsiella Pneumoniae under Saudi Condition.
The study identified the SHV-9, CTX-M-15, TEM-1, IMP-4, KPC2, and KPC3 genes as prevalent in Klebsiella pneumoniae isolates in Saudi Arabia, contributing to resistance against multiple antibiotics.
Characterization of ESBL-Producing Enterobacteria from Fruit Bats in an Unprotected Area of Makokou, Gabon.
This study reports the first detection of multidrug-resistant ESBL-producing enterobacteria in fruit bats in Makokou, Gabon. The study identifies blaCTX-M-15 and blaSHV-11 as the primary ESBL genes responsible for beta-lactam resistance in these isolates.
Phenotypic and molecular characterization of antimicrobial resistant Escherichia coli from urinary tract infections in Port-Harcourt, Nigeria.
The study identified multiple antimicrobial resistance genes in E. coli isolates from urinary tract infections in Port-Harcourt, Nigeria, including blaTEM, blaCTX-M-15, blaSHV, blaOXA-1, blaCMY-2, qnrD, qnrS, aac(6')-Ib, and aacC2. These genes were associated with resistance to various antibiotics, highlighting the complexity of multidrug resistance in these isolates.
A Pilot Study of Chicago Waterways as Reservoirs of Multidrug-Resistant Enterobacteriaceae (MDR-Ent) in a High-Risk Region for Community-Acquired MDR-Ent Infection in Children.
The study identified various multidrug-resistant Enterobacteriaceae (MDR-Ent) in Chicago waterways, including genes encoding beta-lactamases (CTX-M-1, CTX-M-9, SHV-ESBL, CMY-II-AmpC), aminoglycoside modifying enzymes (aac-6'-Ib), quinolone resistance proteins (qnrB), efflux pump components (oqxA/B), and colistin resistance (mcr-1). These genes were found in E. coli, K. pneumoniae, and E. cloacae isolates and conferred resistance to multiple antibiotics.
ESKAPE Bacteria and Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolated from Wastewater and Process Water from German Poultry Slaughterhouses.
The study identified several beta-lactamase genes (bla TEM, bla CTX-M, bla SHV) and the mcr-1 gene conferring resistance to colistin in ESKAPE bacteria and ESBL-producing E. coli isolated from wastewater and process water in German poultry slaughterhouses.
Environmental and genetic determinants of plasmid mobility in pathogenic Escherichia coli.
The study identifies the beta-lactamase gene blaSHV encoded on the plasmid p2766-1, which is associated with increased conjugation efficiency in the presence of macrolides and chloramphenicol.
Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae.
The study identifies various beta-lactamase genes, including bla KPC-2, bla TEM-1B, bla SHV-182, bla OXA-1, bla CTX-M-15, bla ACT-7, bla CTX-M-8, and bla OXA-9, which contribute to β-lactam resistance in carbapenem-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates.
Should we leave the paper currency? A microbiological examination.
The study identified various antimicrobial resistance genes including mecA, vanA, blaTEM, blaSHV, blaCTX-M-1, blaCTX-M-2, blaKPC, and blaOXA-48 in bacteria isolated from Turkish banknotes, highlighting the potential role of paper currency in spreading pathogens and antimicrobial resistance.
Genomic Investigation Reveals Contaminated Detergent as the Source of an Extended-Spectrum-β-Lactamase-Producing Klebsiella michiganensis Outbreak in a Neonatal Unit.
Carbapenem-Resistant Enterobacter hormaechei ST1103 with IMP-26 Carbapenemase and ESBL Gene bla (SHV-178).
The study identifies a multidrug-resistant Enterobacter hormaechei strain L51 carrying the bla IMP-26 carbapenemase gene and bla SHV-178 ESBL gene, along with other resistance genes on a conjugative IncHI2/2A plasmid.
Resistome in Lake Bolonha, Brazilian Amazon: Identification of Genes Related to Resistance to Broad-Spectrum Antibiotics.
The study identified several AMR genes in Lake Bolonha, including bla CTX-M, bla SHV, bla TEM, bla VIM, bla IMP, intl1, and intl2, which confer resistance to beta-lactams and other antibiotics. These genes were found in various bacterial isolates, highlighting the presence of multidrug-resistant bacteria in the lake.
Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.
The study identifies known and novel antimicrobial resistance genes using a machine learning approach on pan-genomes of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Key findings include the detection of resistance genes such as gyrA, parC, ermC, lmrS, aac(6')-aph(2"), dfrG, tetK, and various beta-lactamases.
Antibiotic resistance and virulence patterns of pathogenic Escherichia coli strains associated with acute gastroenteritis among children in Qatar.
The study identified bla CTX-M-G1, bla CTX-M-3, bla CTX-M-15, bla TEM, and bla SHV as the main genes responsible for extended-spectrum beta-lactamase (ESBL) production in EPEC and EAEC strains isolated from children with acute gastroenteritis in Qatar.
Molecular and Clinical Characterization of Multidrug-Resistant and Hypervirulent Klebsiella pneumoniae Strains from Liver Abscess in Taiwan.
Molecular and Clinical Characterization of Multidrug-Resistant and Hypervirulent Klebsiella pneumoniae Strains from Liver Abscess in Taiwan.
Molecular and Clinical Characterization of Multidrug-Resistant and Hypervirulent Klebsiella pneumoniae Strains from Liver Abscess in Taiwan.
Molecular and Clinical Characterization of Multidrug-Resistant and Hypervirulent Klebsiella pneumoniae Strains from Liver Abscess in Taiwan.
Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report.
Putative Protein Biomarkers of Escherichia coli Antibiotic Multiresistance Identified by MALDI Mass Spectrometry.
The study identifies several AMR genes in E. coli isolates, including tet(A), tet(B), blaCTX-M, blaTEM, blaSHV, sul1, sul2, sul3, cmlA, aac(3)-II, aac(3)-IV, aadA, and strA-strB, which confer resistance to tetracycline, ampicillin, cefoxitin, trimethoprim-sulfamethoxazole, chloramphenicol, gentamicin, and streptomycin.
A Genotype-Phenotype Correlation Study of SHV β-Lactamases Offers New Insight into SHV Resistance Profiles.
A Genotype-Phenotype Correlation Study of SHV β-Lactamases Offers New Insight into SHV Resistance Profiles.
A Genotype-Phenotype Correlation Study of SHV β-Lactamases Offers New Insight into SHV Resistance Profiles.
A Genotype-Phenotype Correlation Study of SHV β-Lactamases Offers New Insight into SHV Resistance Profiles.
A Genotype-Phenotype Correlation Study of SHV β-Lactamases Offers New Insight into SHV Resistance Profiles.
A Genotype-Phenotype Correlation Study of SHV β-Lactamases Offers New Insight into SHV Resistance Profiles.
A Genotype-Phenotype Correlation Study of SHV β-Lactamases Offers New Insight into SHV Resistance Profiles.
A Genotype-Phenotype Correlation Study of SHV β-Lactamases Offers New Insight into SHV Resistance Profiles.
A Genotype-Phenotype Correlation Study of SHV β-Lactamases Offers New Insight into SHV Resistance Profiles.
Occurrence, Phenotypic and Molecular Characterization of Extended-Spectrum- and AmpC- β-Lactamase Producing Enterobacteriaceae Isolated From Selected Commercial Spinach Supply Chains in South Africa.
The study identified several beta-lactamase genes, including bla CTX-M, bla TEM, bla SHV, bla OXA, and bla CIT, which confer resistance to various beta-lactam antibiotics in ESBL/AmpC-producing Enterobacteriaceae isolated from spinach supply chains in South Africa.
Klebsiella pneumoniae carriage in low-income countries: antimicrobial resistance, genomic diversity and risk factors.
The study identified various AMR genes and mutations in Klebsiella pneumoniae isolates from pregnant women in low-income countries, highlighting the prevalence of multidrug-resistant strains and the role of environmental factors in their carriage.
Gram-negative bacteria carrying β-lactamase encoding genes in hospital and urban wastewater in Brazil.
The study identified β-lactamase encoding genes, including bla KPC, bla TEM, bla SHV, and bla CTX-M, in Gram-negative bacteria from hospital and urban wastewater in Brazil, highlighting the presence of multidrug-resistant strains.
Emergence of β-lactamase- and carbapenemase- producing Enterobacteriaceae at integrated fish farms.
The study identified several β-lactamase and carbapenemase genes, including bla KPC, bla OXA-48, bla NDM, bla CTX-M-15, bla SHV, bla OXA-1, bla TEM, and bla PER-1, which confer resistance to cephalosporins and carbapenems in Enterobacteriaceae isolated from fish, water, and workers at integrated agriculture-aquaculture systems in Egypt.
Metagenomic Diagnosis for a Culture-Negative Sample From a Patient With Severe Pneumonia by Nanopore and Next-Generation Sequencing.
The study identified several AMR genes in a culture-negative sample from a patient with severe pneumonia, including bla SHV-12, bla KPC-2, bla TEM-1, bla CTX-M-65, aac(3)-IIa, aadA1, dfrA1, sul1, aph(3')-Ia, catA1, fosA, acrA, and rmtB, which confer resistance to various antibiotics.
Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors.
The study identified various antimicrobial resistance genes in Klebsiella isolates from preterm infants, highlighting the presence of multidrug resistance mechanisms.
Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors.
The study identified various antimicrobial resistance genes in Klebsiella isolates from preterm infants, highlighting the presence of multidrug resistance mechanisms.
Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors.
The study identified various antimicrobial resistance genes in Klebsiella isolates from preterm infants, highlighting the presence of multidrug resistance mechanisms.
In vitro conjugation kinetics of AmpC, broad spectrum and extended-spectrum beta-lactamase-producing Escherichia coli donors and various Enterobacteriaceae recipients.
The study characterizes several beta-lactamase genes (blaCTX-M-1, blaCTX-M-15, blaSHV-12, blaTEM-52, blaTEM-1, and blaCMY-2) that confer resistance to ceftazidime and cefotaxime in Escherichia coli donors, highlighting their role in conjugation and horizontal gene transfer among Enterobacteriaceae.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Antimicrobial Resistance Pattern of Escherichia coli Isolated from Frozen Chicken Meat in Bangladesh.
The study identified bla TEM, bla SHV, and bla CTX-M-2 genes in ESBL-producing E. coli isolates from frozen chicken meat in Bangladesh, highlighting the presence of multidrug-resistant and extensively drug-resistant strains.
One year cross-sectional study in adult and neonatal intensive care units reveals the bacterial and antimicrobial resistance genes profiles in patients and hospital surfaces.
The study identified several antimicrobial resistance (AMR) genes, including mecA, bla CTX-M-1 group, bla SHV-like, bla KPC-like, and vanA, in both patient and hospital surface samples from adult and neonatal intensive care units (ICU and NICU). These genes were found to be prevalent in various bacterial species, highlighting the widespread nature of AMR in hospital environments.
Association of intestinal colonization of ESBL-producing Enterobacteriaceae in poultry slaughterhouse workers with occupational exposure-A German pilot study.
The study identified the presence of ESBL-producing E. coli in poultry slaughterhouse workers, with the detection of bla CTX-M-15, bla SHV-12, and bla TEM-135 genes.
Characterization of Extended-Spectrum beta-lactamase-Producing Uropathogenic Escherichia coli Among Iranian Kidney Transplant Patients.
The study identified bla CTX-M, bla TEM, and bla SHV genes as the primary extended-spectrum beta-lactamase (ESBL) genes in uropathogenic Escherichia coli (UPEC) isolates from kidney transplant patients (KTPs) and controls. bla CTX-M was the most prevalent, followed by bla TEM, and bla SHV was less common.
Prediction of Antimicrobial Resistance in Gram-Negative Bacteria From Whole-Genome Sequencing Data.
The study presents machine learning models for predicting antimicrobial resistance in Gram-negative bacteria using whole-genome sequencing data. Key resistance genes identified include AAC(6')-Ib, APH(3")-Ib, OqxB21, FosA2, SHV-200, EC-18, CTX-M-222, KPC-33, OXA-51, and OXA-561.
Plasmid Replicon Typing of Antibiotic-Resistant Escherichia coli From Clams and Marine Sediments.
The study identified various antibiotic resistance genes in E. coli isolates from clams and marine sediments, including blaTEM, blaSHV, blaCTX-M, tet(A), dfrA1, aadA, strA, strB, and ant(3"). These genes were associated with resistance to beta-lactams, tetracycline, trimethoprim/sulfamethoxazole, and streptomycin.
Genomic surveillance of Escherichia coli and Klebsiella spp. in hospital sink drains and patients.
The study identifies various antimicrobial resistance genes, including bla CTX-M, bla SHV, and mcr-4, in Enterobacterales isolates from hospital sink drains and patients, highlighting the role of sinks as reservoirs of resistance genes.
Genomic surveillance of Escherichia coli and Klebsiella spp. in hospital sink drains and patients.
The study identifies various antimicrobial resistance genes, including bla CTX-M, bla SHV, and mcr-4, in Enterobacterales isolates from hospital sink drains and patients, highlighting the role of sinks as reservoirs of resistance genes.
Decreased detection of ESBL- or pAmpC-producing Escherichia coli in broiler breeders imported into Sweden.
The study reports the decrease in detection of ESBL- or pAmpC-producing E. coli in broiler breeders imported into Sweden, with specific identification of bla CMY-2, bla CTX-M-1, and bla SHV-12 genes as responsible for resistance.
Antibacterial potential of Forsythia suspensa polysaccharide against resistant Enterobacter cloacae with SHV-12 extended-spectrum beta-lactamase (ESBL).
The study shows that Forsythia suspensa polysaccharide (FSP) exhibits potent antibacterial activity against Enterobacter cloacae producing SHV-12 ESBL by inhibiting SHV-12 ESBL gene expression.
Treatment Failure in Urinary Tract Infections: A Warning Witness for Virulent Multi-Drug Resistant ESBL- Producing Escherichia coli.
The study identified ESBL-producing E. coli isolates with high levels of multidrug resistance, primarily carrying bla CTX-M, bla SHV, and bla TEM genes, leading to resistance against multiple antibiotics including cephalosporins, fluoroquinolones, and others.
Structural Genomics of repA, repB 1-Carrying IncFIB Family pA1705-qnrS, P911021-tetA, and P1642-tetA, Multidrug-Resistant Plasmids from Klebsiella pneumoniae.
The study characterizes multidrug-resistant plasmids pA1705-qnrS, p911021-tetA, and p1642-tetA from Klebsiella pneumoniae, identifying several AMR genes including beta-lactamases (bla CTX-M-14, bla TEM-1, bla OXA-1, bla SHV-12, bla CTX-M-15, bla CTX-M-65), quinolone resistance gene qnrS1, tetracycline resistance genes tetA (A) and tetA (D), aminoglycoside resistance genes aacA4cr and aacC2, streptomycin resistance genes strA and strB, dihydrofolate reductase genes dfrA1 and dfrA14, sulfonamide resistance gene sul2, macrolide resistance gene mph (A), efflux pump gene oqxAB, chloramphenicol acetyltransferase gene catB3, and tunicamycin resistance gene tmrB.
IMP-38-Producing High-Risk Sequence Type 307 Klebsiella pneumoniae Strains from a Neonatal Unit in China.
The study identifies IMP-38-producing high-risk ST307 Klebsiella pneumoniae strains in a neonatal unit in China, highlighting the acquisition of diverse antimicrobial resistance genes, including blaIMP-38, blaCTX-M-3, blaSHV-2A, blaSHV-28, blaTEM-1, aacA4, catB3, oqxA, oqxB, and fosA6.
IMP-38-Producing High-Risk Sequence Type 307 Klebsiella pneumoniae Strains from a Neonatal Unit in China.
The study identifies IMP-38-producing high-risk ST307 Klebsiella pneumoniae strains in a neonatal unit in China, highlighting the acquisition of diverse antimicrobial resistance genes, including blaIMP-38, blaCTX-M-3, blaSHV-2A, blaSHV-28, blaTEM-1, aacA4, catB3, oqxA, oqxB, and fosA6.
Prevalence and characteristics of extended-spectrum beta-lactamases-producing Escherichia coli from broiler chickens at different day-age.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-14, blaCTX-M-9, blaCTX-M-55, blaCTX-M-15, blaCTX-M-1, blaCTX-M-65, blaCTX-M-74, and blaCTX-M-25, along with PMQR genes such as qnrS, aac(6′)-Ib-cr, qnrB, and qnrA. Additionally, mutations in the QRDR of gyrA and parC were associated with enrofloxacin resistance in ESBL-producing E. coli isolates from broiler chickens.
The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2016.
The report highlights high levels of antimicrobial resistance in zoonotic bacteria such as Salmonella and Campylobacter, with specific emphasis on resistance to fluoroquinolones, tetracyclines, and sulfonamides. It also notes the emergence of multidrug-resistant strains and the presence of ESBL-producing and carbapenemase-producing E. coli in poultry and meat.
The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2017.
The report highlights high levels of antimicrobial resistance in zoonotic bacteria such as Salmonella and Campylobacter, as well as in indicator bacteria like Escherichia coli. Key findings include resistance to multiple antibiotics, including extended-spectrum beta-lactamases (ESBLs), AmpC beta-lactamases, and carbapenemases. Colistin resistance was observed at low levels, and multidrug-resistant strains were prevalent in certain serovars.
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
The study identified multiple AMR genes, including bla CTX-M-55, bla CMY-2, bla CTX-M-1, bla SHV-12, sul2, aac(3)-Ia, aadA, strA, strB, tet(A), tet(B), dfrA14, floR, cmlA1, catA1, catB3, qnrS1, qnrS2, qnrB19, mph(A), mph(B), arr-3, and aac(6')Ib-cr, in ESBL/pAmpC-producing E. coli isolates from broiler production.
Efficacy of Acacia nilotica aqueous extract in treating biofilm-forming and multidrug resistant uropathogens isolated from patients with UTI syndrome.
The study identified several AMR genes including blaTEM, blaSHV, blaCTX, qnrS, aac(3)-Ia, and mexR in multidrug-resistant uropathogens. These genes conferred resistance to various antibiotics such as ampicillin, ceftazidime, ciprofloxacin, gentamicin, and piperacillin.
Distribution of Class B and Class A β-Lactamases in Clinical Strains of Pseudomonas aeruginosa: Comparison of Phenotypic Methods and High-Resolution Melting Analysis (HRMA) Assay.
The study identified various β-lactamase genes, including bla SHV, bla TEM, bla KPC, bla IMP, bla VIM, and bla GES, in Pseudomonas aeruginosa isolates using HRMA assay. These genes were associated with resistance to multiple β-lactam antibiotics.
Detection of New Delhi Metallo-β-lactamase 1 and Cephalosporin Resistance Genes Among Carbapenem-Resistant Enterobacteriaceae in Water Bodies Adjacent to Hospitals in India.
The study identified bla_NDM-1, bla_CTX-M-15, and bla_SHV-11 genes in carbapenem-resistant Enterobacteriaceae from hospital effluents and aquaculture farms in Kerala, India, highlighting the spread of multidrug-resistant bacteria in the environment.
Novel Carbapenem-Resistant Klebsiella pneumoniae ST147 Coharboring bla (NDM-1), bla (OXA-48) and Extended-Spectrum β-Lactamases from Pakistan.
The study identifies a high-risk clone ST147 of Klebsiella pneumoniae coharboring multiple carbapenem resistance genes, including bla NDM-1, bla OXA-48, bla CTX-M, and bla SHV, highlighting the global spread of multidrug-resistant strains.
Therapeutic Effect and Mechanisms of the Novel Monosulfactam 0073.
The novel monosulfactam 0073 showed potent activity against multidrug-resistant Gram-negative bacteria, including those producing various beta-lactamases such as KPC-2, NDM-1, TEM-1, OXA-48, SHV-11, CTX-M-1, and CIT. It exhibited lower MICs compared to aztreonam and had reduced resistance development potential.
High Prevalence and Diversity of Cephalosporin-Resistant Enterobacteriaceae Including Extraintestinal Pathogenic E. coli CC648 Lineage in Rural and Urban Dogs in Northwest Spain.
The study identified a high prevalence of cephalosporin-resistant Enterobacteriaceae in dogs from rural and urban areas in Galicia, Spain, including various ESBL and pAmpC genes such as blaCTX-M-1, blaCTX-M-14, blaCTX-M-15, and others. These genes were found in E. coli and K. pneumoniae isolates, contributing to multidrug resistance.
F Plasmids Are the Major Carriers of Antibiotic Resistance Genes in Human-Associated Commensal Escherichia coli.
The study identifies various antibiotic resistance genes in commensal E. coli isolates, highlighting the prevalence of resistance genes on F plasmids and the role of mobile genetic elements in their dissemination.
Characteristics of Extended-Spectrum β-Lactamase-Producing Escherichia coli From Dogs and Cats Admitted to a Veterinary Teaching Hospital in Taipei, Taiwan From 2014 to 2017.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-55, bla CTX-M-124, bla CTX-M-194, bla CTX-M-174, bla CTX-M-198, bla CTX-M-214, bla TEM-215, and bla SHV-199, in ESBL-producing E. coli isolates from dogs and cats. These genes conferred resistance to beta-lactam antibiotics such as ceftiofur and ampicillin.
Phenotypically distinguishing ESBL-producing pathogens using paper-based surface enhanced Raman sensors.
The study demonstrates the use of paper-based surface-enhanced Raman spectroscopy (SERS) sensors to detect beta-lactamase activity in bacterial cultures, specifically identifying resistance to cephalosporins mediated by TEM-1 and SHV-4 beta-lactamases.
Antibiotic resistance and extended-spectrum β-lactamase in Escherichia coli isolates from imported 1-day-old chicks, ducklings, and turkey poults.
The study identified various extended-spectrum beta-lactamase (ESBL) and ampC beta-lactamase genes, including bla TEM, bla SHV, bla CTX-M, bla OXA-1, and ampC, in Escherichia coli isolates from imported 1-day-old poultry. These genes conferred resistance to multiple beta-lactam antibiotics.
Clinical and Molecular Epidemiologic Characteristics of Ceftazidime/Avibactam-Resistant Carbapenem-Resistant Klebsiella pneumoniae in a Neonatal Intensive Care Unit in China.
The study identified bla_kpc-2, bla_ndm-1, and bla_ndm-5 as the primary carbapenemase genes responsible for ceftazidime/avibactam resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates from a neonatal intensive care unit in China. Additionally, shv-11 and ctx-m-14 were found to contribute to extended-spectrum beta-lactamase activity.
Predicting β-lactam resistance using whole genome sequencing in Klebsiella pneumoniae: the challenge of beta-lactamase inhibitors.
The study identifies several beta-lactamase genes, including bla NDM-1, bla OXA-48, bla KPC-8, and bla KPC-14, which confer resistance to various β-lactam antibiotics. It also highlights the importance of considering complex beta-lactamase backgrounds when predicting antimicrobial resistance using whole-genome sequencing.
Predicting β-lactam resistance using whole genome sequencing in Klebsiella pneumoniae: the challenge of beta-lactamase inhibitors.
The study identifies several beta-lactamase genes, including bla NDM-1, bla OXA-48, bla KPC-8, and bla KPC-14, which confer resistance to various β-lactam antibiotics. It also highlights the importance of considering complex beta-lactamase backgrounds when predicting antimicrobial resistance using whole-genome sequencing.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2017/2018.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, focusing on Salmonella, Campylobacter, and E. coli. It notes high resistance levels to ampicillin, sulfonamides, and tetracyclines in Salmonella and E. coli isolates, along with rising resistance to fluoroquinolones in certain serovars. Carbapenemase-producing E. coli and Salmonella were rarely detected.
Bacterial Profiles and Their Associated Factors of Urinary Tract Infection and Detection of Extended Spectrum Beta-Lactamase Producing Gram-Negative Uropathogens Among Patients with Diabetes Mellitus at Dessie Referral Hospital, Northeastern Ethiopia.
The study identified blaTEM and blaSHV genes in Escherichia coli and Klebsiella pneumoniae isolates, which conferred resistance to ampicillin.
Benchmarking hybrid assembly approaches for genomic analyses of bacterial pathogens using Illumina and Oxford Nanopore sequencing.
The study compared hybrid assembly approaches for bacterial pathogen genomes and identified AMR genes such as blaZ, msr(A), and tet(K) in Staphylococcus aureus.
Emergence of NDM-5-Producing Carbapenem-Resistant Klebsiella pneumoniae and SIM-Producing Hypervirulent Klebsiella pneumoniae Isolated from Aseptic Body Fluid in a Large Tertiary Hospital, 2017-2018: Genetic Traits of blaNDM-Like and blaSIM-Like Genes as Determined by NGS.
The study identified NDM-5-producing CRKP and SIM-producing hvKP strains, highlighting the emergence of novel resistance mechanisms and the effectiveness of tigecycline-carbapenem combinations in treating these infections.
Emergence of NDM-5-Producing Carbapenem-Resistant Klebsiella pneumoniae and SIM-Producing Hypervirulent Klebsiella pneumoniae Isolated from Aseptic Body Fluid in a Large Tertiary Hospital, 2017-2018: Genetic Traits of blaNDM-Like and blaSIM-Like Genes as Determined by NGS.
The study identified NDM-5-producing CRKP and SIM-producing hvKP strains, highlighting the emergence of novel resistance mechanisms and the effectiveness of tigecycline-carbapenem combinations in treating these infections.
Characterization of Hypervirulent Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Among Urinary Tract Infections: The First Report from Iran.
The study identified ESBL genes (bla SHV, bla TEM, bla CTX-M) and PMQR genes (qnrA, qnrB, qnrS) in hypervirulent Klebsiella pneumoniae isolates from urinary tract infections in Iran. These genes contribute to resistance against beta-lactam antibiotics and quinolones.
The Role of Urban Wastewater in the Environmental Transmission of Antimicrobial Resistance: The Current Situation in Italy (2010-2019).
The study identified several AMR genes in urban wastewater treatment plants in Italy, including bla TEM-1, bla AmpC, bla CTX-M-15, bla KPC-3, bla SHV-1, tet A, sul II, erm B, qnr S, int I1, aad A2, dfr 17, aadA 5, aadA 10, sat 1, bla TEM, bla OXA, bla CTX, bla KPC, and tet W. These genes confer resistance to various antibiotics such as beta-lactams, tetracyclines, sulfonamides, macrolides, fluoroquinolones, and aminoglycosides.
The New Klebsiellapneumoniae ST152 Variants with Hypermucoviscous Phenotype Isolated from Renal Transplant Recipients with Asymptomatic Bacteriuria-Genetic Characteristics by WGS.
The study identified several AMR genes in two hypermucoviscous Klebsiella pneumoniae isolates from renal transplant recipients, including bla CTX-M-15, aac(6')-Ib-cr, and others, indicating resistance to various antibiotics.
Colonization of a hand washing sink in a veterinary hospital by an Enterobacter hormaechei strain carrying multiple resistances to high importance antimicrobials.
The study identified multiple antimicrobial resistance genes in an Enterobacter hormaechei strain isolated from a veterinary hospital sink, including blaSHV-12, qnrB2, and mcr-9.1, which confer resistance to cephalosporins, quinolones, and colistin, respectively.
Colonization of a hand washing sink in a veterinary hospital by an Enterobacter hormaechei strain carrying multiple resistances to high importance antimicrobials.
The study identified multiple antimicrobial resistance genes in an Enterobacter hormaechei strain isolated from a veterinary hospital sink, including blaSHV-12, qnrB2, and mcr-9.1, which confer resistance to cephalosporins, quinolones, and colistin, respectively.
Genetic Determinants of Resistance to Extended-Spectrum Cephalosporin and Fluoroquinolone in Escherichia coli Isolated from Diseased Pigs in the United States.
The study identified bla CMY-2, bla CTX-M, and bla SHV-12 genes as major contributors to extended-spectrum cephalosporin resistance, along with qnrB77, qnrB2, qnrS1, qnrS2, and aac(6')-Ib-cr for fluoroquinolone resistance. The colistin resistance gene mcr-9 was also detected in several isolates.
Predictors of Severity and Co-Infection Resistance Profile in COVID-19 Patients: First Report from Upper Egypt.
The study identified various antimicrobial resistance genes in bacterial co-infections among COVID-19 patients, including mecA, NDM-1, KPC, TEM, CTX-M, and SHV. These genes were associated with multidrug-resistant isolates, highlighting the importance of monitoring and managing co-infections in COVID-19 patients.
Colonisation with extended spectrum beta-lactamase-producing and carbapenem-resistant Enterobacterales in children admitted to a paediatric referral hospital in South Africa.
The study identified blaCTX-M as the most prevalent ESBL gene in ESBL-PE isolates, followed by blaTEM and blaSHV. The CRE isolate did not carry common carbapenemase genes.
Characteristics and Epidemiology of Extended-Spectrum β-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae From Red Kangaroo, China.
The study identified multiple AMR genes in a multidrug-resistant Klebsiella pneumoniae isolate from a Red Kangaroo, including beta-lactamases (bla DHA–3, bla SHV–1, bla CTX–M–14, bla TEM–191, bla TEM–1, bla CTX–M–3), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aac(3)-IIa, aac(6′)-Ib-cr, aadA16, arr-3), quinolone resistance genes (qnrS1, qnrB2), macrolide resistance gene (mphA), sulfonamide resistance genes (sul3, sul1), dihydrofolate reductase (dfrA3, dfrA27), chloramphenicol resistance gene (floR), tetracycline resistance genes (tetG, tetR), and multidrug efflux pump (qacEΔ1).
Mechanisms of Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa: Results of the GERPA Multicenter Study.
The study identifies multiple mechanisms of resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa, including the production of extended-spectrum beta-lactamases (ESBLs) and carbapenemases, overproduction of the intrinsic cephalosporinase PDC, and mutations in regulatory and peptidoglycan recycling genes.
The importance of using whole genome sequencing and extended spectrum beta-lactamase selective media when monitoring antimicrobial resistance.
The study highlights the utility of whole genome sequencing (WGS) in monitoring antimicrobial resistance (AMR) trends, particularly in identifying ESBL genes such as bla CTX-M-1, bla CTX-M-15, bla SHV-12, bla CMY-2, and bla DHA-1, along with other resistance genes like sul2, tet(A), dfrA17, aadA5, ant3-1a, strA, strB, and fosA3 in E. coli isolates from pig surveillance.
Extended Spectrum Beta-Lactamase-Resistant Determinants among Carbapenem-Resistant Enterobacteriaceae from Beef Cattle in the North West Province, South Africa: A Critical Assessment of Their Possible Public Health Implications.
The study identified various carbapenemase and ESBL genes in carbapenem-resistant Enterobacteriaceae isolated from beef cattle in South Africa, highlighting the presence of resistance determinants that could pose public health risks.
Molecular Epidemiology of Antibiotic-Resistant Escherichia coli from Farm-To-Fork in Intensive Poultry Production in KwaZulu-Natal, South Africa.
The study identified the presence of bla CTX-M, sul1, tetA, and tetB genes in Escherichia coli isolates from various stages of the farm-to-fork continuum in intensive poultry production in South Africa.
Molecular detection of extended spectrum beta-lactamase genes in Escherichia coli clinical isolates from diarrhoeic children in Kano, Nigeria.
The study identifies the presence of ESBLs in E. coli isolates from diarrhoeic children in Kano, Nigeria, with bla CTX-M and bla TEM being the most prevalent genes associated with resistance to β-lactam antibiotics.
Isolation and molecular characterization of multidrug-resistant Escherichia coli from chicken meat.
The study identified multiple antibiotic resistance genes in multidrug-resistant E. coli isolates from chicken meat, including tetA, sul1, aadA1, ereA, aac-3-IV, cmlA, catA1, SHV, and CITM, highlighting the prevalence of resistance to various antibiotics such as tetracycline, sulfonamide, streptomycin, erythromycin, gentamicin, chloramphenicol, and beta-lactams.
Fecal Klebsiella pneumoniae Carriage Is Intermittent and of High Clonal Diversity.
The study identified 25 antibiotic resistance genes in 80 Klebsiella pneumoniae isolates, primarily encoding efflux pumps and inactivating enzymes. Notably, blaSHV, emrB, emrR, marA, marR, msbA, ompK37, oqxA, oqxB, acrA, vgaC, fosA, tet(D), APH(3")-Ib, APH(6)-Id, aadA, qnrS2, rpoB2, mexF, and oprN were found to confer resistance to various antibiotics.
Transferable Resistance to Highest Priority Critically Important Antibiotics for Human Health in Escherichia coli Strains Obtained From Livestock Feces in Uruguay.
The study identified multiple AMR genes in E. coli isolates from livestock in Uruguay, including qnrB19, qnrS1, qnrE1, bla CTX-M-8, bla CTX-M-2, bla CTX-M-15, bla CTX-M-14, bla CTX-M-55, bla CMY-2, bla SHV-12, and mcr-1, highlighting the presence of transferable resistance to critically important antibiotics.
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing.
The study identified various AMR genes in E. coli isolates from bloodstream infections, including genes conferring resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, and trimethoprim. Additionally, mutations in quinolone resistance-determining regions of gyrA, parC, and parE were associated with ciprofloxacin resistance.
Molecular analysis of blaSHV, blaTEM, and blaCTX-M in extended-spectrum β-lactamase producing Enterobacteriaceae recovered from fecal specimens of animals.
The study identified blaCTX-M, blaTEM, and blaSHV genes in ESBL-producing Enterobacteriaceae from animal fecal samples, highlighting their prevalence and distribution among different bacterial species.
Genomic Features of MCR-1 and Extended-Spectrum beta-lactamase-Producing Enterobacterales from Retail Raw Chicken in Egypt.
The study identified mcr-1-positive Enterobacterales in retail chicken in Egypt, including Escherichia coli and Citrobacter freundii. It also found the fosA4 gene associated with fosfomycin resistance and various extended-spectrum beta-lactamase (ESBL) genes such as bla CTX-M-9, bla CTX-M-14, bla CTX-M-15, and bla SHV-12.
Virulent and multidrug-resistant Klebsiella pneumoniae from clinical samples in Balochistan.
The study identifies multidrug-resistant Klebsiella pneumoniae isolates from clinical samples in Balochistan, highlighting the presence of tetracycline resistance gene tetB, sulfonamide resistance gene Sul1, and extended-spectrum beta-lactamase gene SHV. Additionally, virulence factors fimH1 and EntB were detected.
Detection and characterization of ESBL-producing Enterobacteriaceae from the gut of subsistence farmers, their livestock, and the surrounding environment in rural Nepal.
The study identified bla CTX-M-15 as the predominant ESBL gene in ESBL-producing Enterobacteriaceae isolates from subsistence farming communities in Nepal, highlighting the high prevalence of this gene in human, animal, and environmental samples.
Antibiotic resistance plasmid composition and architecture in Escherichia coli isolates from meat.
The study characterizes various AMR genes in plasmids from meat-derived E. coli isolates, highlighting the diversity and clustering of resistance genes such as bla CTX-M-1, aadA5, sul2, and others, along with their association with specific plasmid incompatibility groups.
Characterization of Enterococci- and ESBL-Producing Escherichia coli Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified several AMR genes in Enterococcus and ESBL-producing E. coli isolates from bovine mastitis cases in Egypt, including erm(B), tetL, aac-aphD, vanA, and vanB.
Prevalence of ESβL, AmpC and Colistin-Resistant E. coli in Meat: A Comparison between Pork and Wild Boar.
The study identified bla CTX-M1, bla TEM, bla SHV, and bla CTX-M2 genes in E. coli isolates from pork and wild boar meat, indicating the presence of extended-spectrum beta-lactamase (ESβL) resistance. No mcr-1 gene was found in colistin-resistant E. coli isolates from wild boar meat.
Emergence of carbapenem-resistant Klebsiella pneumoniae harbouring bla (OXA-48)-like genes in China.
Emergence of carbapenem-resistant Klebsiella pneumoniae harbouring bla (OXA-48)-like genes in China.
Emergence of carbapenem-resistant Klebsiella pneumoniae harbouring bla (OXA-48)-like genes in China.
Distribution of Beta-Lactamase Producing Gram-Negative Bacterial Isolates in Isabela River of Santo Domingo, Dominican Republic.
The study identified several beta-lactamase genes, including bla TEM, bla OXA, bla SHV, and bla KPC, as well as other resistance genes such as CTX-M-15, CTX-M-55, OXA-1, OXA-72, OXA-132, KPC-3, QnrS1, QnrB19, sul2, sul1, dfrA12, dfrA14, dfrA17, mphA, aadA, aadA2, aadA5, ampC, ampC1, ampH, PmrF, bacA, and eptA, in various Gram-negative bacterial isolates from the Isabela River in the Dominican Republic.
Molecular Detection of Antibiotic-Resistant Genes in Pseudomonas aeruginosa from Nonclinical Environment: Public Health Implications in Mthatha, Eastern Cape Province, South Africa.
The study identified bla SHV, bla TEM, and bla CTX-M genes in Pseudomonas aeruginosa isolates from nonclinical environments, indicating the presence of extended-spectrum beta-lactamase (ESBL) resistance mechanisms.
Molecular Epidemiology and Characterization of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Urine at a Teaching Hospital in Taiwan.
The study identified several AMR genes and mutations contributing to carbapenem resistance in K. pneumoniae isolates from urine, including bla TEM, bla SHV, bla CTX-M, bla DHA, bla KPC, bla VIM, and mutations in ompK35 and ompK36.
Molecular Characterization of Carbapenemase-Producing Klebsiella pneumoniae Isolated from Egyptian Pediatric Cancer Patients Including a Strain with a Rare Gene-Combination of β-Lactamases.
The study identified the presence of multiple carbapenemase genes, including bla OXA-48, bla NDM-1, and bla IMP-1, in carbapenem-resistant Klebsiella pneumoniae isolates from Egyptian pediatric cancer patients. It also reported a rare combination of these genes in one isolate. The study highlights the dissemination of multidrug-resistant clones among hospital wards.
The Animal-foods-environment interface of Klebsiella pneumoniae in Germany: an observational study on pathogenicity, resistance development and the current situation.
The study identifies several AMR genes, including bla CTX-M-15, bla OXA-48, bla SHV-1, bla SHV-2, bla SHV-27, bla TEM-1, aac(3)-IIc, qnrS1, and mcr-1, in Klebsiella pneumoniae isolates from various non-human sources in Germany. Fluoroquinolone resistance was associated with mutations in GyrA and ParC.
The Animal-foods-environment interface of Klebsiella pneumoniae in Germany: an observational study on pathogenicity, resistance development and the current situation.
The study identifies several AMR genes, including bla CTX-M-15, bla OXA-48, bla SHV-1, bla SHV-2, bla SHV-27, bla TEM-1, aac(3)-IIc, qnrS1, and mcr-1, in Klebsiella pneumoniae isolates from various non-human sources in Germany. Fluoroquinolone resistance was associated with mutations in GyrA and ParC.
The Animal-foods-environment interface of Klebsiella pneumoniae in Germany: an observational study on pathogenicity, resistance development and the current situation.
The study identifies several AMR genes, including bla CTX-M-15, bla OXA-48, bla SHV-1, bla SHV-2, bla SHV-27, bla TEM-1, aac(3)-IIc, qnrS1, and mcr-1, in Klebsiella pneumoniae isolates from various non-human sources in Germany. Fluoroquinolone resistance was associated with mutations in GyrA and ParC.
High β-lactam resistance in Gram-negative bacteria associated with kennel cough and cat flu in Egypt.
The study identified various β-lactam resistance genes, including bla SHV, bla CTX-M, bla TEM, bla CMY, and bla ACT, as well as qnrS, which confer resistance to β-lactams and quinolones in Gram-negative bacteria associated with kennel cough and cat flu in Egypt.
Endophytic Lifestyle of Global Clones of Extended-Spectrum beta-lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?
The study identifies multiple AMR genes in endophytic ESBL-producing Enterobacterales isolated from fresh vegetables, highlighting their potential role in the spread of antibiotic resistance.
Multidrug Resistant Klebsiella pneumoniae ST101 Clone Survival Chain From Inpatients to Hospital Effluent After Chlorine Treatment.
The study identifies multiple AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae ST101 clone, including blaCTX-M-15, blaOXA-48, blaOXA-1, blaSHV-106, blaTEM-150, aac(3)-IIa, aac(6')-Ib-cr, oqxA10, oqxB17, fosA, catB3, dfrA14, tet(D), and mutations in mgrB, ompK35, gyrA, and parC.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Molecular investigation of an outbreak associated with total parenteral nutrition contaminated with NDM-producing Leclercia adecarboxylata.
The study identified NDM-1, TEM-1B, and SHV-12 carbapenemase genes along with various other AMR genes in Leclercia adecarboxylata isolates causing an outbreak linked to contaminated TPN.
Taxonomy, virulence determinants and antimicrobial susceptibility of Aeromonas spp. isolated from bacteremia in southeastern China.
The study identified several beta-lactamase genes (blaTEM, blaSHV, blaAQU-1, blaMOX, blaCepH, blaCphA) and the aac(6')-Ib-cr gene associated with antimicrobial resistance in Aeromonas isolates from bacteremia cases in southeastern China.
Molecular characterization of extended-spectrum beta-lactamase-producing Escherichia coli isolated from postpartum uterine infection in dairy cattle in India.
The study identified a high prevalence of ESBL-producing E. coli in postpartum uterine infections in dairy cattle in India, with bla CTX-M, bla TEM, and bla SHV genes being the most common. These genes confer resistance to various β-lactam antibiotics.
Wild Boars Carry Extended-Spectrum β-Lactamase- and AmpC-Producing Escherichia coli.
Wild boars in Germany carry ESBL/AmpC-producing E. coli, with bla CTX-M-1, bla SHV-12, and bla CMY-2 being the most common beta-lactamase genes. Additional resistance genes include sul1, sul2, sul3, dfrA1, dfrA5, dfrA14, dfrA17, tet(A), cmlA, floR, and qnrS.
Rapid detection of extended spectrum β-lactamase producing Escherichia coli isolated from fresh pork meat and pig cecum samples using multiplex recombinase polymerase amplification and lateral flow strip analysis.
The study developed a rapid detection method for extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli using multiplex recombinase polymerase amplification (RPA) combined with a lateral flow strip assay (LFA). The method successfully detected bla CTX-M, bla SHV, and bla OXA genes in E. coli isolates from pork and pig cecum samples.
Rapid detection of extended spectrum β-lactamase producing Escherichia coli isolated from fresh pork meat and pig cecum samples using multiplex recombinase polymerase amplification and lateral flow strip analysis.
The study developed a rapid detection method for extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli using multiplex recombinase polymerase amplification (RPA) combined with a lateral flow strip assay (LFA). The method successfully detected bla CTX-M, bla SHV, and bla OXA genes in E. coli isolates from pork and pig cecum samples.
Rapid detection of extended spectrum β-lactamase producing Escherichia coli isolated from fresh pork meat and pig cecum samples using multiplex recombinase polymerase amplification and lateral flow strip analysis.
The study developed a rapid detection method for extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli using multiplex recombinase polymerase amplification (RPA) combined with a lateral flow strip assay (LFA). The method successfully detected bla CTX-M, bla SHV, and bla OXA genes in E. coli isolates from pork and pig cecum samples.
Identification of a Novel Hybrid Plasmid Encoding KPC-2 and Virulence Factors in Klebsiella pneumoniae Sequence Type 11.
The study identifies a novel hybrid plasmid, pCRHV-C2244, in a carbapenem-resistant Klebsiella pneumoniae ST11 isolate, which encodes the beta-lactamase KPC-2 along with various virulence factors. The plasmid shows stable maintenance without significant fitness costs and enhances virulence in vitro and in vivo.
Identification of a Novel Hybrid Plasmid Encoding KPC-2 and Virulence Factors in Klebsiella pneumoniae Sequence Type 11.
The study identifies a novel hybrid plasmid, pCRHV-C2244, in a carbapenem-resistant Klebsiella pneumoniae ST11 isolate, which encodes the beta-lactamase KPC-2 along with various virulence factors. The plasmid shows stable maintenance without significant fitness costs and enhances virulence in vitro and in vivo.
Prevalence and antimicrobial resistance of Klebsiella species isolated from clinically ill companion animals.
The study identified several extended-spectrum cephalosporin (ESC) resistance genes, including blaCTX-M-15, blaCTX-M-3, blaCTX-M-65, blaDHA-1, blaCMY-2, blaSHV-1, blaSHV-11, blaSHV-28, and blaTEM-1, in Klebsiella pneumoniae and Klebsiella oxytoca strains isolated from clinically ill companion animals. These genes were associated with resistance to various beta-lactam antibiotics.
Prevalence and antimicrobial resistance of Klebsiella species isolated from clinically ill companion animals.
The study identified several extended-spectrum cephalosporin (ESC) resistance genes, including blaCTX-M-15, blaCTX-M-3, blaCTX-M-65, blaDHA-1, blaCMY-2, blaSHV-1, blaSHV-11, blaSHV-28, and blaTEM-1, in Klebsiella pneumoniae and Klebsiella oxytoca strains isolated from clinically ill companion animals. These genes were associated with resistance to various beta-lactam antibiotics.
Prevalence and antimicrobial resistance of Klebsiella species isolated from clinically ill companion animals.
The study identified several extended-spectrum cephalosporin (ESC) resistance genes, including blaCTX-M-15, blaCTX-M-3, blaCTX-M-65, blaDHA-1, blaCMY-2, blaSHV-1, blaSHV-11, blaSHV-28, and blaTEM-1, in Klebsiella pneumoniae and Klebsiella oxytoca strains isolated from clinically ill companion animals. These genes were associated with resistance to various beta-lactam antibiotics.
Detection of extended spectrum beta-lactamase genes in Pseudomonas aeruginosa isolated from patients in rural Eastern Cape Province, South Africa.
The study identified blaTEM, blaSHV, and blaCTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) resistance in Pseudomonas aeruginosa isolates from the Eastern Cape Province, South Africa. Additionally, blaIMP was detected in a small percentage of isolates.
Characterization of Extended-Spectrum β-Lactamase-Producing and AmpC β-Lactamase-Producing Enterobacterales Isolated from Companion Animals in Korea.
The study identified several extended-spectrum β-lactamase (ESBL) and AmpC β-lactamase genes, including bla TEM, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla CTX-M-61, bla CTX-M-27, bla CTX-M-65, bla CIT, bla DHA, bla EBC, and bla SHV, in various Enterobacterales isolates from companion animals in South Korea.
Molecular Detection of Antibiotic Resistance Genes in Shiga Toxin-Producing E. coli Isolated from Different Sources.
The study identified multiple antibiotic resistance genes in Shiga toxin-producing E. coli (STEC) isolates, including aadA1, aac(3)-I, ere(A), ampC, blaSHV, blaCMY, and tet(A), which conferred resistance to various antibiotics such as streptomycin, gentamicin, erythromycin, ampicillin, penicillin, cephalosporin, and tetracycline.
Antimicrobial Resistance Genes and Diversity of Clones among ESBL- and Acquired AmpC-Producing Escherichia coli Isolated from Fecal Samples of Healthy and Sick Cats in Portugal.
The study identified various ESBL and qAmpC genes in E. coli isolates from cats, highlighting the presence of bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-27, bla CTX-M-9, bla TEM, bla SHV-28, and bla CMY-2, along with other resistance genes such as tet(A), tet(B), sul1, sul2, aac(6')-Ib-cr, and armA.
Acinetobacter baumannii Antibiotic Resistance Mechanisms.
The paper reviews various beta-lactamases and other resistance mechanisms in Acinetobacter baumannii, focusing on their roles in resistance to beta-lactams, aminoglycosides, and other antibiotics.
Acinetobacter baumannii Antibiotic Resistance Mechanisms.
The paper reviews various beta-lactamases and other resistance mechanisms in Acinetobacter baumannii, focusing on their roles in resistance to beta-lactams, aminoglycosides, and other antibiotics.
Multicentre study of the burden of multidrug-resistant bacteria in the aetiology of infected diabetic foot ulcers.
The study identified various AMR genes including bla CTX-M, bla TEM, bla SHV, mecA, bla VIM, bla KPC, and bla NDM in multidrug-resistant bacteria causing infected diabetic foot ulcers. These genes conferred resistance to beta-lactams, carbapenems, and other antibiotics.
Extended-spectrum beta-lactamase-producing strains among diarrhoeagenic Escherichia coli-prospective traveller study with literature review.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-9, bla TEM, bla SHV, and bla CTX-M-15, in diarrhoeagenic Escherichia coli (DEC) strains from travellers. These genes confer resistance to beta-lactam antibiotics such as cefoxitin, cefotaxime, and ceftazidime.
Comprehensive Pathogen Identification, Antibiotic Resistance, and Virulence Genes Prediction Directly From Simulated Blood Samples and Positive Blood Cultures by Nanopore Metagenomic Sequencing.
The study demonstrates the use of nanopore sequencing for rapid identification of pathogens, antibiotic resistance genes, and virulence genes from simulated blood samples and positive blood cultures. It identified 39 antibiotic resistance genes and 77 virulence genes in a Klebsiella pneumoniae strain, including blaKPC-2, blaSHV-12, blaTEM-1, blaCTX-M-65, rmtB, aadA, AAC(6')-IIb, baeR, mdtABC, acrAB, oqxAB, tet, H-NS, gyrA, and parC.
Characterization of antimicrobial susceptibility, extended-spectrum β-lactamase genes and phylogenetic groups of Shigatoxin producing Escherichia coli isolated from patients with diarrhea in Iran.
The study identified the presence of extended-spectrum beta-lactamase (ESBL) genes, including blaTEM, blaCTX-M9, blaSHV, and blaOXA, in Shigatoxin-producing Escherichia coli isolates from patients with diarrhea in Iran. These genes confer resistance to beta-lactam antibiotics, particularly ampicillin.
Genomic Diversity and Virulence Potential of ESBL- and AmpC-β-Lactamase-Producing Escherichia coli Strains From Healthy Food Animals Across Europe.
The study identifies various ESBL and AmpC beta-lactamase genes, including bla SHV-12, bla CTX-M-1, bla CTX-M-2, bla CTX-M-14, bla CTX-M-15, bla TEM-52, and bla CMY-2, along with the mcr-1 gene conferring colistin resistance in E. coli isolates from food animals in Europe.
Genetic determinants facilitating the evolution of resistance to carbapenem antibiotics.
The study identifies bla SHV-12 as a gene that confers resistance to ertapenem through its beta-lactamase activity. The gene was experimentally validated by cloning and transformation into K. pneumoniae strains.
Antimicrobial Resistance Glides in the Sky-Free-Living Birds as a Reservoir of Resistant Escherichia coli With Zoonotic Potential.
The study identified multiple AMR genes and mutations in E. coli from free-living birds, highlighting the zoonotic potential of these resistant strains. Key findings include bla CTX-M-15, bla CMY-2, bla SHV-12, bla TEM-1B, qnrS1, qnrB19, mcr-1, fosA7, aac(3)-IIa, ant(3")-Ia, aph(3")-Ib, and aph(6)-Id, as well as mutations in gyrA, parC, and parE.
AMR-Diag: Neural network based genotype-to-phenotype prediction of resistance towards β-lactams in Escherichia coli and Klebsiella pneumoniae.
The study identified several β-lactamase genes including TEM-1, CTX-M-15, NDM-5, SHV, and OXA that confer resistance to β-lactam antibiotics in E. coli and K. pneumoniae. These genes were validated through WGS and phenotypic characterization.
The Direct Semi-Quantitative Detection of 18 Pathogens and Simultaneous Screening for Nine Resistance Genes in Clinical Urine Samples by a High-Throughput Multiplex Genetic Detection System.
The study presents a high-throughput multiplex genetic detection system (UTI-HMGS) capable of semi-quantitative detection of 18 uropathogens and simultaneous screening for nine antibiotic resistance genes directly from clinical urine samples within 4 hours. The system demonstrated high sensitivity and specificity for the detection of uropathogens and resistance genes, with improved detection rates for several important uropathogens compared to conventional culture methods.
Multiresistant Bacteria Isolated from Intestinal Faeces of Farm Animals in Austria.
The study identified several AMR genes, including CTX-M-1, CTX-M-14, SHV-12, TEM-52, and VanA, in multiresistant bacteria isolated from the intestinal faeces of farm animals in Austria.
Serotyping and Antimicrobial Resistance Profile of Enteric Nontyphoidal Salmonella Recovered from Febrile Neutropenic Patients and Poultry in Egypt.
The study identified several antimicrobial resistance genes, including bla CTX-m, bla SHV, bla TEM, and aac (6')-Ib, in both human and poultry isolates of non-typhoidal Salmonella. These genes were found to confer resistance to various antibiotics such as cefotaxime, ampicillin, and gentamicin.
Frequency, Local Dynamics, and Genomic Characteristics of ESBL-Producing Escherichia coli Isolated From Specimens of Hospitalized Horses.
The study identified several ESBL genes, including blaCTX-M-1, blaCTX-M-15, blaSHV-12, blaOXA-1, blaCTX-M-14, blaCTX-M-3, and blaCMY-2, along with aminoglycoside resistance genes like aac(3)-IV, sulfonamide resistance genes sul1 and sul2, and trimethoprim resistance genes dfrA and dfrG, in ESBL-producing E. coli isolates from hospitalized horses.
Multidrug-resistant Klebsiella pneumoniae harboring extended spectrum β-lactamase encoding genes isolated from human septicemias.
The study identified multiple beta-lactamase genes including bla CTX-M-15, bla SHV-1, bla SHV-11, bla SHV-27, bla SHV-106, and bla TEM, along with carbapenemase genes bla KPC2/3 and bla OXA-48, contributing to multidrug resistance in Klebsiella pneumoniae isolates from human septicemias.
Multidrug-resistant Klebsiella pneumoniae harboring extended spectrum β-lactamase encoding genes isolated from human septicemias.
The study identified multiple beta-lactamase genes including bla CTX-M-15, bla SHV-1, bla SHV-11, bla SHV-27, bla SHV-106, and bla TEM, along with carbapenemase genes bla KPC2/3 and bla OXA-48, contributing to multidrug resistance in Klebsiella pneumoniae isolates from human septicemias.
Multidrug-resistant Klebsiella pneumoniae harboring extended spectrum β-lactamase encoding genes isolated from human septicemias.
The study identified multiple beta-lactamase genes including bla CTX-M-15, bla SHV-1, bla SHV-11, bla SHV-27, bla SHV-106, and bla TEM, along with carbapenemase genes bla KPC2/3 and bla OXA-48, contributing to multidrug resistance in Klebsiella pneumoniae isolates from human septicemias.
Multidrug-resistant Klebsiella pneumoniae harboring extended spectrum β-lactamase encoding genes isolated from human septicemias.
The study identified multiple beta-lactamase genes including bla CTX-M-15, bla SHV-1, bla SHV-11, bla SHV-27, bla SHV-106, and bla TEM, along with carbapenemase genes bla KPC2/3 and bla OXA-48, contributing to multidrug resistance in Klebsiella pneumoniae isolates from human septicemias.
Multimodal Interventions to Prevent and Control Carbapenem-Resistant Enterobacteriaceae and Extended-Spectrum beta-lactamase Producer-Associated Infections at a Tertiary Care Hospital in Egypt.
The study identified several carbapenemase genes (bla KPC, bla NDM, bla VIM, bla OXA-48, bla IMP) and extended-spectrum beta-lactamase genes (bla CTX-m, bla TEM, bla SHV) in CRE and ESBL-producing isolates, highlighting the prevalence of these resistance mechanisms in a tertiary care hospital in Egypt.
Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance.
The study identifies plasmid-mediated cephalosporin resistance in Salmonella Typhi isolates from India, including bla SHV-12, bla TEM-1B, bla DHA-1, qnrB7, qnrB4, aac(6')Iaa, dfrA14, sul1, and sul2 genes. Chromosomal mutations in gyrA (S83F, D87N, S80I) and parC (S80I, E84K) contribute to fluoroquinolone resistance.
Genotypic Characterization of Clinical Klebsiella spp. Isolates Collected From Patients With Suspected Community-Onset Sepsis, Sweden.
The study identified a high prevalence of multidrug-resistant Klebsiella spp., with resistance genes against beta-lactam, fosfomycin, and quinolone detected in most isolates. Misidentification of species by MALDI-TOF MS was common, highlighting the need for genomic methods for accurate species identification.
Molecular Epidemiology of Human Papillomaviruses, Neisseria gonorrhoeae, Chlamydia trachomatis and Mycoplasma genitalium among Female Sex Workers in Burkina Faso: Prevalence, Coinfections and Drug Resistance Genes.
The study identified several antibiotic resistance genes, including bla QNR B, bla GES, bla SHV, bla CTX-M, and bla QNR S, in Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium among female sex workers in Burkina Faso.
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
The Spatiotemporal Dynamics and Microevolution Events That Favored the Success of the Highly Clonal Multidrug-Resistant Monophasic Salmonella Typhimurium Circulating in Europe.
The study identifies various AMR genes in the highly clonal multidrug-resistant monophasic Salmonella Typhimurium ST34, including beta-lactamases, sulfonamide resistance genes, tetracycline resistance genes, phenicol resistance genes, and polymyxin resistance genes.
Colonization with selected antibiotic resistant bacteria among a cohort of Sri Lankan university students.
The study identified bla CTX-M, bla SHV, and bla TEM as the most common genetic determinants of ESBL production in E. coli and K. pneumoniae. Additionally, mecA and pvl genes were detected in MRSA isolates.
Characterization of beta-lactamase and quinolone resistant Clostridium perfringens recovered from broiler chickens with necrotic enteritis in Bangladesh.
The study identified beta-lactamase genes (bla TEM, bla SHV, bla OXA) and quinolone resistance genes (qnrB, qnrS) in Clostridium perfringens isolates from broiler chickens with necrotic enteritis, indicating multidrug resistance.
Isolation, Antimicrobial Resistance Phenotypes, and Virulence Genes of Bordetella bronchiseptica From Pigs in China, 2018-2020.
The study identified several antimicrobial resistance genes in Bordetella bronchiseptica isolates from pigs in China, including aac(3)-IV, aac6'-Ib, rmtA, blaTEM, blaSHV, oqxB, and tetA. These genes confer resistance to various antibiotics such as aminoglycosides, beta-lactams, fluoroquinolones, and tetracyclines.
Longitudinal study on antibiotic susceptibility in commensal E. coli from geese raised in free-range production systems.
The study identified several beta-lactamase genes, including blaSHV, blaCTX-M-1, and blaTEM, in commensal E. coli from geese raised in free-range systems. These genes confer resistance to various beta-lactam antibiotics.
Carbapenem-resistant Enterobacter cloacae complex in a tertiary Hospital in Northeast China, 2010-2019.
The study identified several carbapenemase-encoding genes, including blaNDM-1, blaNDM-5, blaIMP-4, and blaKPC-2, along with various beta-lactamase genes such as TEM-1, CTX-M-15, CTX-M-3, SHV-12, and CTX-M-14, in carbapenem-resistant Enterobacter cloacae complex isolates.
Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity.
Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity.
Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity.
Intense intestinal carriage and subsequent acquisition of multidrug-resistant enterobacteria in neonatal intensive care unit in Morocco.
The study identified the bla CTX-M-1, bla CTX-M-9, bla SHV, bla TEM, and bla OXA-48 genes as the primary resistance mechanisms in multidrug-resistant Enterobacteriaceae isolated from neonates in a Moroccan NICU.
The Beta-Lactam Resistome Expressed by Aerobic and Anaerobic Bacteria Isolated from Human Feces of Healthy Donors.
The study identifies several beta-lactamase genes, including blaTEM, blaSHV, blaKPC, blaCMY, blaBIL, blaCFX, and blaP, in aerobic and anaerobic bacteria isolated from the feces of healthy donors, highlighting the human gut as a reservoir of beta-lactam resistance.
ESBL/AmpC-Producing Escherichia coli in Wild Boar: Epidemiology and Risk Factors.
The study identified bla CTX-M, bla TEM, bla CMY, and bla SHV genes in ESBL/AmpC-producing E. coli from wild boar, highlighting the role of wild boar as a potential reservoir of antimicrobial resistance.
High prevalence of bla(CTX-M) and bla(SHV) among ESBL producing E. coli isolates from beef cattle in China's Sichuan-Chongqing Circle.
The study identified a high prevalence of bla(CTX-M) and bla(SHV) genes among ESBL-producing E. coli isolates from beef cattle in the Sichuan-Chongqing Circle of China. These genes confer resistance to various beta-lactam antibiotics.
In Vitro Activity of Cefotetan against ESBL-Producing Escherichia coli and Klebsiella pneumoniae Bloodstream Isolates from the MERINO Trial.
Cefotetan demonstrated favorable in vitro efficacy against ESBL-producing E. coli and K. pneumoniae bloodstream isolates, with MIC 50 and MIC 90 values of 0.25 mg/L and 2 mg/L, respectively. Isolates carrying ampC genes showed higher MICs, while those with CTX-M-15 had lower MICs. Several beta-lactamase genes, including bla CTX-M-15, bla CTX-M-27, bla SHV-106, and bla DHA-1, were identified as contributors to resistance.
A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex.
The study introduces Kleborate, a tool for analyzing genomes of Klebsiella pneumoniae and its related species complex, focusing on AMR and virulence determinants. Key findings include the identification of SHV beta-lactamase, OmpK35 and OmpK36 porins, and MgrB/PmrB regulators as critical factors in carbapenem and colistin resistance.
Characterization of resistance mechanisms of Enterobacter cloacae Complex co-resistant to carbapenem and colistin.
The study identified blaKPC-2, blaNDM-1, mcr-4.3, ecr, ampC, blaCTX-M-14, blaCTX-M-9, blaSHV, and blaTEM as genes contributing to carbapenem and colistin resistance in Enterobacter cloacae Complex strains.
Genomic New Insights Into Emergence and Clinical Therapy of Multidrug-Resistant Klebsiella pneumoniae in Infected Pancreatic Necrosis.
Genomic New Insights Into Emergence and Clinical Therapy of Multidrug-Resistant Klebsiella pneumoniae in Infected Pancreatic Necrosis.
Clinical and Molecular Characteristics of Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae Isolates in a Tertiary Hospital in Shanghai, China.
The study identified the presence of the carbapenemase gene blaKPC-2 and extended-spectrum beta-lactamase gene blaSHV in all 16 CR-hvKP isolates, contributing to their multidrug resistance.
QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics.
QPX7728 is a novel β-lactamase inhibitor with broad-spectrum activity against serine and metallo-β-lactamases, including Class A, C, D, and B enzymes. It effectively inhibits clinically relevant β-lactamases such as KPC-2, CTX-M-15, SHV-12, TEM-43, OXA-48, OXA-23, NDM-1, and VIM-1.
Genetic characterization of extended-spectrum beta-lactamase- and carbapenemase-producing Escherichia coli isolated from Egyptian hospitals and environments.
The study identified several beta-lactamase genes, including blaTEM, blaCTX-M15, blaSHV, blaOXA-48, and blaIMP, which confer resistance to various β-lactam antibiotics in Escherichia coli isolates from Egyptian hospitals and environments.
Detection of bla(TEM), bla(CTX-M), bla(CMY), and bla(SHV) Genes Among Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolated from Migratory Birds Travelling to Bangladesh.
The study identified bla(TEM), bla(CTX-M), bla(CMY), and bla(SHV) genes in extended-spectrum beta-lactamase-producing Escherichia coli isolated from migratory birds in Bangladesh, highlighting the role of migratory birds as potential carriers of antibiotic resistance genes.
Plasmid analysis of NDM metallo-β-lactamase-producing Enterobacterales isolated in Vietnam.
The study characterizes bla NDM-1 and bla NDM-4 carrying plasmids in Enterobacterales isolates from Vietnam, highlighting their role in carbapenem resistance and horizontal gene transfer.
Plasmid analysis of NDM metallo-β-lactamase-producing Enterobacterales isolated in Vietnam.
The study characterizes bla NDM-1 and bla NDM-4 carrying plasmids in Enterobacterales isolates from Vietnam, highlighting their role in carbapenem resistance and horizontal gene transfer.
Plasmid analysis of NDM metallo-β-lactamase-producing Enterobacterales isolated in Vietnam.
The study characterizes bla NDM-1 and bla NDM-4 carrying plasmids in Enterobacterales isolates from Vietnam, highlighting their role in carbapenem resistance and horizontal gene transfer.
Plasmid analysis of NDM metallo-β-lactamase-producing Enterobacterales isolated in Vietnam.
The study characterizes bla NDM-1 and bla NDM-4 carrying plasmids in Enterobacterales isolates from Vietnam, highlighting their role in carbapenem resistance and horizontal gene transfer.
Emerging Threat of Multidrug Resistant Pathogens From Neonatal Sepsis.
The study identified several AMR genes, including bla CTX-M-15, bla SHV-2, bla NDM-1, and qnrB, which confer resistance to various antibiotics in E. coli and K. pneumoniae isolated from neonatal sepsis cases.
First Description of Various Bacteria Resistant to Heavy Metals and Antibiotics Isolated from Polluted Sites in Tunisia.
The study identified the presence of blaTEM, blaSHV, silE, cusA, and merA genes in environmental bacteria isolated from polluted sites in Tunisia, indicating resistance to antibiotics and heavy metals.
Prevalence and Characterization of Extended-Spectrum β-Lactamase-Producing Antibiotic-Resistant Escherichia coli and Klebsiella pneumoniae in Ready-to-Eat Street Foods.
The study identified the presence of extended-spectrum beta-lactamase (ESBL)-producing antibiotic-resistant Escherichia coli and Klebsiella pneumoniae in ready-to-eat street foods, highlighting the prevalence of bla TEM, bla CTX, bla SHV, and bla NDM genes, which confer resistance to multiple antibiotics.
Analysis of Wastewater Reveals the Spread of Diverse Extended-Spectrum beta-lactamase-Producing E. coli Strains in uMgungundlovu District, South Africa.
The study identified CTX-M, SHV, and TEM-type ESBL genes in E. coli isolates from wastewater treatment plants in South Africa, highlighting the prevalence of extended-spectrum beta-lactamase-producing E. coli strains.
High Prevalence of ESBL and Plasmid-Mediated Quinolone Resistance Genes in Salmonella enterica Isolated from Retail Meats and Slaughterhouses in Egypt.
The study identified various ESBL and PMQR genes in Salmonella enterica isolates from retail meats and slaughterhouses in Egypt, highlighting their high prevalence and potential public health implications.
High Prevalence of ESBL and Plasmid-Mediated Quinolone Resistance Genes in Salmonella enterica Isolated from Retail Meats and Slaughterhouses in Egypt.
The study identified various ESBL and PMQR genes in Salmonella enterica isolates from retail meats and slaughterhouses in Egypt, highlighting their high prevalence and potential public health implications.
Antibiotic-resistant bacteria, antibiotic resistance genes, and antibiotic residues in wastewater from a poultry slaughterhouse after conventional and advanced treatments.
The study identified several antibiotic resistance genes (ARGs) in wastewater from a poultry slaughterhouse, including bla TEM, bla CTX-M-1, bla SHV-12, mcr-1, ermB, sul1, tetM, bla OXA-48, bla CMY-2, and vanA. These genes were found to confer resistance to various antibiotics such as beta-lactams, macrolides, sulfonamides, tetracyclines, carbapenems, and glycopeptides.
Antimicrobial resistance profiles and genetic basis of resistance among non-fastidious Gram-negative bacteria recovered from ready-to-eat foods in Kibera informal housing in Nairobi, Kenya.
The study identified several beta-lactamase genes including bla TEM, bla CTX-M, bla SHV, and bla OXA-1, along with class 1 and 2 integrons, contributing to antimicrobial resistance in Gram-negative bacteria from ready-to-eat foods in Kibera, Kenya.
Genomic insights into the diversity, virulence and resistance of Klebsiella pneumoniae extensively drug resistant clinical isolates.
The study identified various beta-lactamase genes, including blaSHV-11, blaKPC-2, and blaNDM-1, along with qnrS1, aadA1, dfrA1, and sul1, which contribute to multidrug resistance in extensively drug-resistant Klebsiella pneumoniae isolates.
High β-Lactam and Quinolone Resistance of Enterobacteriaceae from the Respiratory Tract of Sheep and Goat with Respiratory Disease.
The study identified high β-lactam and quinolone resistance in Enterobacteriaceae from sheep and a goat with respiratory disease, highlighting the presence of bla TEM, bla SHV, bla CTX-M, and qnrS genes.
Occurrence of bla (CTX-MGp1) and bla (CTX-MGp26) in third generation cephalosporin-resistant and carbapenem- resistant bacterial isolates from southwest region of Saudi Arabia-a preliminary study
The study identified bla CTX-M Group1 and bla CTX-M Group26 as prevalent in third-generation cephalosporin-resistant and carbapenem-resistant bacterial isolates from the Jizan region of Saudi Arabia. bla CTX-M was the most common gene, followed by bla SHV and bla TEM.
Climatological and Epidemiological Conditions Are Important Factors Related to the Abundance of bla(KPC) and Other Antibiotic Resistance Genes (ARGs) in Wastewater Treatment Plants and Their Effluents, in an Endemic Country.
The study identified the prevalence of antibiotic resistance genes (ARGs) in wastewater treatment plants (WWTPs) in Colombia, highlighting the significant presence of bla KPC, sul 1, sul 2, erm B, and others. It also found that environmental factors such as dissolved oxygen and precipitation correlate with the abundance of these genes.
Emergence of Klebsiella pneumoniae ST307 Co-Producing CTX-M with SHV and KPC from Paediatric Patients at Shenzhen Children's Hospital, China.
The study identifies the emergence of Klebsiella pneumoniae ST307 co-producing CTX-M with SHV and KPC in paediatric patients at Shenzhen Children's Hospital, China. It characterizes various carbapenemase and extended-spectrum beta-lactamase encoding genes, highlighting the multidrug-resistant nature of these isolates.
Prevalence and characterization of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolated from raw vegetables retailed in Southern Thailand.
The study identified the prevalence of ESBL-producing E. coli and K. pneumoniae in raw vegetables in Southern Thailand, highlighting the presence of bla SHV as the most common ESBL-encoding gene, along with bla TEM, bla CTX-M1, and bla CTX-M9.
The Epidemiology, Virulence and Antimicrobial Resistance of Invasive Klebsiella pneumoniae at a Children's Medical Center in Eastern China.
The study identified multiple beta-lactam resistance genes, including bla SHV-11, bla FOX-1, bla ACT-1, bla CTX-M-14, bla TEM-1, bla VIM-1, bla NDM-1, bla KPC-2, and bla OXA-1, in invasive Klebsiella pneumoniae isolates. Additionally, hypervirulence genes such as iroB, p rmpA, mrkD, wabG, Uge, fimH, and ycfM were prevalent.
Genetic relatedness in extended-spectrum beta-lactamase-producing Escherichia coli from clinical isolates using enterobacterial repetitive intergenic consensus polymerase chain reaction.
The study identified blaTEM, blaSHV, blaCTX-M, and blaOXA as the primary ESBL genes in E. coli isolates, with blaTEM being the most prevalent. These genes conferred resistance to various beta-lactam antibiotics.
Infective endocarditis caused by Enterobacteriaceae: phenotypic and molecular characterization of Escherichia coli and Klebsiella pneumoniae in Rio de Janeiro, Brazil.
The study identified several AMR genes in E. coli and K. pneumoniae isolates causing infective endocarditis, including genes conferring resistance to beta-lactams, aminoglycosides, sulfonamides, trimethoprim, fosfomycin, and fluoroquinolones. These genes were detected through molecular analysis and resistance profiling.
Infective endocarditis caused by Enterobacteriaceae: phenotypic and molecular characterization of Escherichia coli and Klebsiella pneumoniae in Rio de Janeiro, Brazil.
The study identified several AMR genes in E. coli and K. pneumoniae isolates causing infective endocarditis, including genes conferring resistance to beta-lactams, aminoglycosides, sulfonamides, trimethoprim, fosfomycin, and fluoroquinolones. These genes were detected through molecular analysis and resistance profiling.
Infective endocarditis caused by Enterobacteriaceae: phenotypic and molecular characterization of Escherichia coli and Klebsiella pneumoniae in Rio de Janeiro, Brazil.
The study identified several AMR genes in E. coli and K. pneumoniae isolates causing infective endocarditis, including genes conferring resistance to beta-lactams, aminoglycosides, sulfonamides, trimethoprim, fosfomycin, and fluoroquinolones. These genes were detected through molecular analysis and resistance profiling.
Amikacin in combination with zinc pyrithione prevents growth of a multidrug-resistant carbapenem-resistant Klebsiella pneumoniae isolate.
The study identifies aminoglycoside resistance mediated by aac(6')-Ib and beta-lactam resistance conferred by blaTEM-1, blaSHV-11, blaSHV-12, and blaKPC-2 in a multidrug-resistant CRKP isolate. The combination of amikacin and zinc pyrithione effectively overcomes amikacin resistance.
Amikacin in combination with zinc pyrithione prevents growth of a multidrug-resistant carbapenem-resistant Klebsiella pneumoniae isolate.
The study identifies aminoglycoside resistance mediated by aac(6')-Ib and beta-lactam resistance conferred by blaTEM-1, blaSHV-11, blaSHV-12, and blaKPC-2 in a multidrug-resistant CRKP isolate. The combination of amikacin and zinc pyrithione effectively overcomes amikacin resistance.
Prevalence, antibiotic susceptibility, and presence of drug resistance genes in Aeromonas spp. isolated from freshwater fish in Kelantan and Terengganu states, Malaysia.
The study identified multiple antibiotic resistance genes in Aeromonas spp. isolated from freshwater fish in Malaysia, including blaTEM, blaSHV, sul1, aadA, strA-strB, tetA, and tetE, which confer resistance to ampicillin, sulfamethoxazole, streptomycin, and tetracycline.
Occurrence of Colibacillosis in Broilers and Its Relationship With Avian Pathogenic Escherichia coli (APEC) Population Structure and Molecular Characteristics.
The study identified multiple antimicrobial resistance genes in Avian Pathogenic Escherichia coli (APEC) isolates, including beta-lactamases (blaCMY-2, blaSHV-12, blaTEM-52, blaCTX-M-1), aminoglycoside resistance genes (aac(3)-IV, aadA, strA, strB, aph(3')-Ib), sulfonamide resistance gene (sul1), tetracycline resistance genes (tet(A), tet(B)), trimethoprim resistance gene (dfrA), quinolone resistance genes (qnrS1, qnrS2, qnrB19), macrolide resistance genes (mph(A), mph(B)), and chloramphenicol resistance gene (catA1).
Antimicrobial Resistance and Comparative Genome Analysis of Klebsiella pneumoniae Strains Isolated in Egypt.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant K. pneumoniae strain KPE16, including bla NDM-1, bla CTX-M-15, and various aminoglycoside, sulfonamide, and tetracycline resistance genes. Additionally, chromosomal mutations in ompK36, ompK37, and acrR contribute to resistance.
Characterization of ESBL-Producing Escherichia coli and Klebsiella pneumoniae Isolated from Clinical Samples in a Northern Portuguese Hospital: Predominance of CTX-M-15 and High Genetic Diversity.
The study identified the predominance of CTX-M-15 and high genetic diversity among ESBL-producing E. coli and K. pneumoniae isolates, including bla CTX-M-15, bla CTX-M-27, bla CTX-M-1, bla KPC-2/3, bla SHV-12, bla SHV-27, bla SHV-11, bla SHV-28, tet(A), and tet(B) genes.
Characterization of ESBL-Producing Escherichia coli and Klebsiella pneumoniae Isolated from Clinical Samples in a Northern Portuguese Hospital: Predominance of CTX-M-15 and High Genetic Diversity.
The study identified the predominance of CTX-M-15 and high genetic diversity among ESBL-producing E. coli and K. pneumoniae isolates, including bla CTX-M-15, bla CTX-M-27, bla CTX-M-1, bla KPC-2/3, bla SHV-12, bla SHV-27, bla SHV-11, bla SHV-28, tet(A), and tet(B) genes.
Characterization of ESBL-Producing Escherichia coli and Klebsiella pneumoniae Isolated from Clinical Samples in a Northern Portuguese Hospital: Predominance of CTX-M-15 and High Genetic Diversity.
The study identified the predominance of CTX-M-15 and high genetic diversity among ESBL-producing E. coli and K. pneumoniae isolates, including bla CTX-M-15, bla CTX-M-27, bla CTX-M-1, bla KPC-2/3, bla SHV-12, bla SHV-27, bla SHV-11, bla SHV-28, tet(A), and tet(B) genes.
Characterization of ESBL-Producing Escherichia coli and Klebsiella pneumoniae Isolated from Clinical Samples in a Northern Portuguese Hospital: Predominance of CTX-M-15 and High Genetic Diversity.
The study identified the predominance of CTX-M-15 and high genetic diversity among ESBL-producing E. coli and K. pneumoniae isolates, including bla CTX-M-15, bla CTX-M-27, bla CTX-M-1, bla KPC-2/3, bla SHV-12, bla SHV-27, bla SHV-11, bla SHV-28, tet(A), and tet(B) genes.
Characterization of E. coli Isolates Producing Extended Spectrum Beta-Lactamase SHV-Variants from the Food Chain in Germany.
The study identified SHV-12 as the predominant beta-lactamase variant in E. coli isolates from the German food chain, primarily associated with poultry. It also characterized the genetic environments of blaSHV-12 on IncX3 and IncI1 plasmids, and noted the presence of the fluoroquinolone resistance gene qnrS1.
Characterization of E. coli Isolates Producing Extended Spectrum Beta-Lactamase SHV-Variants from the Food Chain in Germany.
The study identified SHV-12 as the predominant beta-lactamase variant in E. coli isolates from the German food chain, primarily associated with poultry. It also characterized the genetic environments of blaSHV-12 on IncX3 and IncI1 plasmids, and noted the presence of the fluoroquinolone resistance gene qnrS1.
Characterization of E. coli Isolates Producing Extended Spectrum Beta-Lactamase SHV-Variants from the Food Chain in Germany.
The study identified SHV-12 as the predominant beta-lactamase variant in E. coli isolates from the German food chain, primarily associated with poultry. It also characterized the genetic environments of blaSHV-12 on IncX3 and IncI1 plasmids, and noted the presence of the fluoroquinolone resistance gene qnrS1.
Isolation of Ciprofloxacin and Ceftazidime-Resistant Enterobacterales From Vegetables and River Water Is Strongly Associated With the Season and the Sample Type.
The study identified mcr-1, bla CTX-M, bla SHV, and bla TEM genes in Enterobacterales isolates from vegetables and river water, indicating resistance to colistin and various beta-lactam antibiotics.
Isolation of Salmonella spp. from black spiny-tailed iguana (Ctenosaura similis) meat commercialised in markets of León city, Nicaragua.
The study identified the presence of Salmonella spp. in meat from black spiny-tailed iguanas, with a focus on the detection of extended-spectrum beta-lactamase (ESBL) genes, particularly blaSHV, blaTEM, and blaCTX-M, which conferred resistance to amoxicillin/clavulanic acid and cephalexin.
Antibiotic resistance in the pathogenic foodborne bacteria isolated from raw kebab and hamburger: phenotypic and genotypic study.
The study identified several antibiotic resistance genes, including blaTEM, blaSHV, blaZ, and mecA, in various foodborne pathogens isolated from raw kebab and hamburger samples. These genes were found to confer resistance to multiple antibiotics, highlighting the presence of multidrug-resistant bacteria in these food products.
Molecular Epidemiological Analysis of ST11-K64 Extensively Drug-Resistant Klebsiella pneumoniae Infections Outbreak in Intensive Care and Neurosurgery Units Based on Whole-Genome Sequencing.
The study identified multiple AMR genes in ST11-K64 XDRKp strains, including beta-lactamases, aminoglycoside resistance genes, and efflux pumps, contributing to extensive drug resistance.
Semirapid Detection of Piperacillin/Tazobactam Resistance and Extended-Spectrum Resistance to β-Lactams/β-Lactamase Inhibitors in Clinical Isolates of Escherichia coli.
The study identified bla TEM, bla SHV, and bla OXA-1 genes as the primary contributors to piperacillin/tazobactam resistance and extended-spectrum resistance to β-lactams/β-lactamase inhibitors in E. coli isolates.
Extended-Spectrum β-Lactam Resistant Klebsiella pneumoniain and Escherichia coli in Wild European Hedgehogs (Erinaceus europeus) Living in Populated Areas.
The study identified several β-lactamase resistance genes, including bla CTX-M-15, bla SHV-28, bla CMY-1, bla CMY-2, and bla OXA-48, in extended-spectrum β-lactam-resistant Klebsiella pneumoniae and Escherichia coli isolated from wild European hedgehogs in Catalonia, Spain.
Virulence, Antimicrobial Resistance and Biofilm Production of Escherichia coli Isolates from Healthy Broiler Chickens in Western Algeria.
The study identified the presence of bla TEM, bla CTX-M−1, and bla SHV genes in E. coli isolates from healthy broiler chickens in Western Algeria, indicating the spread of antimicrobial-resistant E. coli strains.
Extended-Spectrum-β-Lactamase- and AmpC-Producing Escherichia coli in Domestic Dogs: Spread, Characterisation and Associated Risk Factors.
The study identified bla CTX-M, bla TEM, bla CMY, and bla SHV as the primary AMR genes in ESBL/AmpC-producing E. coli from domestic dogs, with bla CTX-M being the most prevalent. These genes were associated with resistance to various cephalosporins and other beta-lactam antibiotics.
Biofilm Formation of Clinical Klebsiella pneumoniae Strains Isolated from Tracheostomy Tubes and Their Association with Antimicrobial Resistance, Virulence and Genetic Diversity.
The study identified ESβL genes (bla SHV, bla TEM, and bla CTX-M group 1 and 9) in K. pneumoniae isolates from tracheostomy tubes, which conferred resistance to ceftazidime and cefotaxime.
Comparative genome analysis of colistin-resistant OXA-48-producing Klebsiella pneumoniae clinical strains isolated from two Iranian hospitals.
The study identifies multiple AMR genes, including blaOXA-48, blaNDM-1, blaCTX-M-15, blaTEM-1, and blaSHV, along with mutations in mgrB, pmrA, pmrB, phoQ, ramA, and crrB contributing to colistin resistance in K. pneumoniae strains.
Transmission Dynamics of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 Strains Carrying Capsular Loci KL64 and rmpA/rmpA2 Genes.
The study identified multiple AMR genes and mutations in ST11-KL64 CRKP isolates, including bla KPC-2, rmtB, catA2, fosA, qnrS1, sul2, tet(A), aadA2, dfrA14, bla CTX-M-65, bla SHV-12, bla TEM-1B, iucABCD, iutA, rmpA2, and mutations in GyrA (S83I, D87G) and ParC (S80I).
Genetic diversity and antibiotic resistance of Shigella spp. isolates from food products.
The study identified bla SHV, bla OXA, bla CTX-M-1, and bla CTX-M-8 genes in Shigella isolates from food products, indicating beta-lactam resistance. All isolates were multidrug-resistant, showing resistance to multiple antibiotics.
Bacteriological and histopathological findings in cetaceans that stranded in the Philippines from 2017 to 2018.
The study identified multiple antibiotic-resistant bacteria from cetaceans stranded in the Philippines, highlighting the presence of resistance genes such as ermB, aadA, aac(6')-Ib, blaTEM, blaCTX-M, blaSHV, blaOXA, qnrS1, tet(A), and mph(A).
Molecular epidemiology of antibiotic-resistant genes and potent inhibitors against TEM, CTX-M-14, CTX-M-15, and SHV-1 proteins of Escherichia coli in district Peshawar, Pakistan.
The study identified the presence of ESBL genes including bla-CTX-M, bla-TEM, bla-SHV, and bla-CTX-M-14 in E. coli isolates from Peshawar, Pakistan. These genes were responsible for resistance to various antibiotics such as cephalosporins, penicillins, and aztreonam.
Molecular epidemiology of antibiotic-resistant genes and potent inhibitors against TEM, CTX-M-14, CTX-M-15, and SHV-1 proteins of Escherichia coli in district Peshawar, Pakistan.
The study identified the presence of ESBL genes including bla-CTX-M, bla-TEM, bla-SHV, and bla-CTX-M-14 in E. coli isolates from Peshawar, Pakistan. These genes were responsible for resistance to various antibiotics such as cephalosporins, penicillins, and aztreonam.
Genetic evaluation of ESBL-producing Escherichia coli urinary isolates in Otago, New Zealand.
The study identified various ESBL genes, including bla CTX-M, bla TEM, bla SHV, and bla OXA, in ESBL-producing E. coli isolates from Otago, New Zealand. The most prevalent ESBL gene was bla CTX-M, with several subtypes such as CTX-M-14, CTX-M-15, CTX-M-27, and CTX-M-55. Additionally, other beta-lactamase genes like bla CMY-2 were also detected. The study highlights the genetic diversity of ESBL-Ec isolates and the presence of multiple resistance mechanisms.
Efficacy and mechanism of carvacrol with octanoic acid against mastitis causing multi-drug-resistant pathogens.
The study identified the presence of bla CTX-M, bla SHV, and bla TEM genes in E. coli FcW5, which confer resistance to various beta-lactam antibiotics. These genes were experimentally validated through PCR amplification and sequencing.
Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units.
The study evaluated the use of respiratory metagenomics to detect antimicrobial resistance genes and improve treatment of secondary infections in ICU patients. It identified several beta-lactam resistance genes, macrolide resistance genes, and sulfonamide resistance genes in various bacterial species.
Phenotypic and genotypic detection of extended spectrum β-lactamases among Escherichia coli and Klebsiella pneumoniae isolates from type 2 diabetic patients with urinary tract infections.
The study identified blaTEM and blaSHV genes as the primary contributors to ESBL production in E. coli and K. pneumoniae isolates from T2DM patients with UTIs, with blaTEM being the most prevalent.
Co-conjugation of Virulence Plasmid and KPC Plasmid in a Clinical Klebsiella pneumoniae Strain.
The study characterizes a carbapenem-resistant hypervirulent Klebsiella pneumoniae strain that harbors a conjugative virulence plasmid and a bla KPC–2-bearing plasmid. The virulence plasmid contains multiple resistance genes, including bla KPC–2, qnrB4, bla DHA–1, sul1, msr(E), mph(E), bla TEM–1B, aac(3)-IId, bla SHV–12, mph(A), bla CTX–M–65, bla TEM–1B, fosA3, and rmtB. The study also shows that these plasmids can be transferred to other bacterial strains, contributing to the spread of multidrug-resistant and hypervirulent K. pneumoniae.
High-Resolution Genomic Profiling of Carbapenem-Resistant Klebsiella pneumoniae Isolates: A Multicentric Retrospective Indian Study.
The study identifies various carbapenem resistance genes such as blaOXA232, blaNDM1, blaNDM5, blaOXA181, and others in Klebsiella pneumoniae isolates from India. It also characterizes mutations in ompK35 and ompK36 contributing to carbapenem resistance.
Antibacterial effect of cerium oxide nanoparticle against Pseudomonas aeruginosa.
The study found that cerium oxide nanoparticles (CNPs) and Scaffold@CNPs significantly reduced the expression of the genes shv, kpc, and imp in Pseudomonas aeruginosa, indicating their potential to combat antibiotic resistance.
Molecular characterization of enterohemorrhagic Escherichia coli isolated from diarrhea samples from human, livestock, and ground beef in North Jordan.
The study identified ESBL-producing EHEC isolates carrying bla SHV and bla TEM genes, indicating resistance to beta-lactam antibiotics.
The Relationship between Antibiotic Susceptibility and pH in the Case of Uropathogenic Bacteria.
The study identified several AMR genes including aac(69)-Ib-cr, oqxAB, sul2, tem, shv, ctx-m, and oxa in uropathogenic bacteria. These genes were associated with resistance to various antibiotics such as gentamicin, ciprofloxacin, norfloxacin, and trimethoprim/sulfamethoxazole.
Characterization of Oral Enterobacteriaceae Prevalence and Resistance Profile in Chronic Kidney Disease Patients Undergoing Peritoneal Dialysis.
The study identified several antibiotic resistance genes, including sul1, intI1, bla CTX-M, and bla SHV, in Enterobacteriaceae isolates from chronic kidney disease patients undergoing peritoneal dialysis. These genes were associated with resistance to sulfamethoxazole, cephalothin, ceftazidime, meropenem, ampicillin, and cefotaxime.
Prevalence of ESBL and AmpC genes in E. coli isolates from urinary tract infections in the north of Iran.
The study identified the prevalence of ESBL and AmpC genes in E. coli isolates from urinary tract infections in the north of Iran, highlighting the significant presence of blaSHV, blaTEM, blaCTX-M, MOX, EBC, and CIT genes.
Prevalence and characterization of antimicrobial resistance among gram-negative bacteria isolated from febrile hospitalized patients in central Ethiopia.
High prevalence of ESBL-producing gram-negative bacteria (81.5%) and carbapenem resistance (7.4%) was observed, with more than half of the isolates carrying two or more ESBL genes. The study highlights the need for improved antimicrobial stewardship and local resistance monitoring.
Resistance Patterns, mcr-4 and OXA-48 Genes, and Virulence Factors of Escherichia coli from Apennine Chamois Living in Sympatry with Domestic Species, Italy.
The study identified the colistin resistance gene mcr-4 and carbapenems resistance gene OXA-48 in Escherichia coli isolates from wild and domestic ungulates in Italy, highlighting the presence of these resistance mechanisms in wildlife.
Antimicrobial Susceptibility Profiles among Pseudomonas aeruginosa Isolated from Professional SCUBA Divers with Otitis Externa, Swimming Pools and the Ocean at a Diving Operation in South Africa.
The study identified multiple beta-lactamase genes (blaAmpC, blaTEM, blaOxa-4, CTX-M1, blaSHV), sulfonamide resistance genes (sul1, sul2), and integron genes (IntI1, IntI2) in P. aeruginosa isolates from SCUBA divers, swimming pools, and the ocean in Sodwana Bay, South Africa, indicating a high level of multidrug resistance.
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
The study identified several beta-lactamase genes, including bla CTX-M-27, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla SHV-12, and bla TEM-1, which confer resistance to beta-lactam antibiotics. Other resistance genes such as aadA5, aph(3")-Ib, aph(6)-Id, mph(A), sul1, sul2, tet(A), and dfrA17, dfrA12, dfrA1, and dfrA14 were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates in Finland.
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
The study identified several beta-lactamase genes, including bla CTX-M-27, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla SHV-12, and bla TEM-1, which confer resistance to beta-lactam antibiotics. Other resistance genes such as aadA5, aph(3")-Ib, aph(6)-Id, mph(A), sul1, sul2, tet(A), and dfrA17, dfrA12, dfrA1, and dfrA14 were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates in Finland.
Case report of enterobacter hormaechei in sheep with respiratory disease and death.
The study reports the first case of Enterobacter hormaechei causing respiratory disease and death in sheep, highlighting the presence of blaSHV and blaKPC genes conferring resistance to multiple beta-lactam antibiotics.
Therapeutic effect of biosynthetic gold nanoparticles on multidrug-resistant Escherichia coli and Salmonella species isolated from ruminants.
The study identified beta-lactam resistance genes bla TEM, bla SHV, bla OXA, and bla CTX-M in multidrug-resistant E. coli and Salmonella spp. isolated from ruminants. These genes conferred resistance to ampicillin, amoxicillin, and cefotaxime.
Loads of Coliforms and Fecal Coliforms and Characterization of Thermotolerant Escherichia coli in Fresh Raw Milk Cheese.
The study identified antibiotic resistance genes blaSHV, blaCTX-M, qnrS, tet(A), and tet(B) in thermotolerant E. coli strains from raw milk cheese, highlighting the presence of multidrug-resistant strains and the need for monitoring antimicrobial resistance in food products.
Application of mNGS in the Etiological Analysis of Lower Respiratory Tract Infections and the Prediction of Drug Resistance.
The study identified several AMR genes using mNGS, including bla OXA-23, bla OXA-51, bla TEM, bla CTX-M, bla SHV, bla KPC, and mecA, which were associated with resistance to various antibiotics in different bacterial species.
Genetic diversity and multidrug resistance of phylogenic groups B2 and D in InPEC and ExPEC isolated from chickens in Central China.
The study identifies several AMR genes and mutations in E. coli isolates from chickens in Central China, including aminoglycoside resistance genes strA, strB, and aadA, beta-lactamase genes CTX-M, SHV, OXA, and TEM, and quinolone resistance mutations S83L and D87N in gyrA.
Antimicrobial Resistance (AMR) of Bacteria Isolated from Dogs with Canine Parvovirus (CPV) Infection: The Need for a Rational Use of Antibiotics in Companion Animal Health.
The study identified several beta-lactamase genes, including blaTEM, blaCTX-M-II, blaSHV, blaOXA, and blaDHA, which confer resistance to various antibiotics in bacteria isolated from dogs with canine parvovirus infection.
Persistence of Antibiotic-Resistant Escherichia coli Strains Belonging to the B2 Phylogroup in Municipal Wastewater under Aerobic Conditions.
The study identifies the persistence of antibiotic-resistant E. coli strains, particularly those belonging to the B2 phylogroup, in municipal wastewater under aerobic conditions. It highlights the prevalence of ESBL-producing E. coli, including CTX-M-9 and SHV types, which contribute to resistance against beta-lactam antibiotics.
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China.
The study identifies multiple antimicrobial resistance genes in multidrug-resistant E. coli isolates from pig farms in China, including ESBL genes, fluoroquinolone resistance genes, carbapenem resistance genes, and colistin resistance genes. It highlights the widespread presence of these resistance mechanisms and their potential to spread to human pathogens.
Genomic characterization of multidrug-resistant Salmonella serovar Kentucky ST198 isolated in poultry flocks in Spain (2011-2017).
The study identified multiple antimicrobial resistance genes in multidrug-resistant Salmonella serovar Kentucky ST198 isolates from Spain, including genes conferring resistance to aminoglycosides, beta-lactams, sulfonamides, tetracyclines, trimethoprim, and colistin.
High prevalence of antibiotic resistance in pathogenic foodborne bacteria isolated from bovine milk.
The study identified bla TEM, bla SHV, mec A, and bla Z genes in E. coli, Salmonella spp., and S. aureus isolates from bovine milk, highlighting the high prevalence of antibiotic resistance in foodborne pathogens.
Mortality associated with third-generation cephalosporin resistance in Enterobacteriaceae bloodstream infections at one South African hospital.
The study identified several ESBL genes, including blaCTX-M-15, blaCARB-2, blaSHV-27, blaCTX-M-14, blaCTX-M-27, and blaCTX-M-3, associated with third-generation cephalosporin resistance in Enterobacteriaceae bloodstream infections.
Environmental surveillance of ESBL and carbapenemase-producing gram-negative bacteria in a Ghanaian Tertiary Hospital.
The study identified various ESBL and carbapenemase genes, including bla NDM-1, bla OXA-48-like, bla CTX-M-15, bla SHV, bla OXA-1, and tet(X3), in environmental samples from a Ghanaian hospital, highlighting the presence of multidrug-resistant gram-negative bacteria.
Association between Timing of Colonization and Risk of Developing Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Infection in Hospitalized Patients.
The study identifies blaSHV-11 and blaTEM-1 as genes responsible for carbapenem resistance in KPC-producing Klebsiella pneumoniae isolates, highlighting their role in multidrug resistance.
Pathogenic E. coli from Cattle as a Reservoir of Resistance Genes to Various Groups of Antibiotics.
The study identified various AMR genes in pathogenic E. coli strains from cattle in Romania and France, highlighting the presence of multidrug-resistant (MDR) strains and the diversity of resistance mechanisms.
A Descriptive Analysis of Urinary ESBL-Producing-Escherichia coli in Cerdanya Hospital.
The study identified various AMR genes and mutations in urinary ESBL-producing E. coli isolates, including bla CTX-M, bla OXA-1, bla SHV-12, and aac(6')-Ib-cr, along with mutations in gyrA, parC, and parE associated with ciprofloxacin resistance.
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
The study identified multiple AMR genes in multidrug-resistant E. coli and K. pneumoniae isolates from Kuwait, including beta-lactamases (blaKPC-2, blaCTX-M-15, blaOXA-1, blaCMY-4, blaTEM), aminoglycoside-modifying enzymes (aac(3)-IIa, aph(6)-Id, aadA5), sulfonamide resistance genes (sul1, sul2), quinolone resistance genes (gyrA_D87N, qnrB1), and others. Colistin resistance was linked to the pmrB_R256G mutation.
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
The study identified multiple AMR genes in multidrug-resistant E. coli and K. pneumoniae isolates from Kuwait, including beta-lactamases (blaKPC-2, blaCTX-M-15, blaOXA-1, blaCMY-4, blaTEM), aminoglycoside-modifying enzymes (aac(3)-IIa, aph(6)-Id, aadA5), sulfonamide resistance genes (sul1, sul2), quinolone resistance genes (gyrA_D87N, qnrB1), and others. Colistin resistance was linked to the pmrB_R256G mutation.
Identification, Characterization, and Virulence Gene Expression of Marine Enterobacteria in the Upper Gulf of Thailand.
The study identified and characterized beta-lactamase genes (ampC, blaSHV, and blaTEM) in marine enterobacteria from the Upper Gulf of Thailand, highlighting their role in resistance to β-lactam antibiotics such as ampicillin and ticarcillin.
WGS-Based Phenotyping and Molecular Characterization of the Resistome, Virulome and Plasmid Replicons in Klebsiella pneumoniae Isolates from Powdered Milk Produced in Germany.
The study identified multiple AMR genes in K. pneumoniae isolates from powdered milk, including blaSHV variants, oqx genes, fosA, pmrB_R256G, and mcr-9. These genes conferred resistance to beta-lactams, chloramphenicol, quinolones, fosfomycin, and colistin. Despite some isolates carrying mcr-9, they remained susceptible to colistin.
WGS-Based Phenotyping and Molecular Characterization of the Resistome, Virulome and Plasmid Replicons in Klebsiella pneumoniae Isolates from Powdered Milk Produced in Germany.
The study identified multiple AMR genes in K. pneumoniae isolates from powdered milk, including blaSHV variants, oqx genes, fosA, pmrB_R256G, and mcr-9. These genes conferred resistance to beta-lactams, chloramphenicol, quinolones, fosfomycin, and colistin. Despite some isolates carrying mcr-9, they remained susceptible to colistin.
WGS-Based Phenotyping and Molecular Characterization of the Resistome, Virulome and Plasmid Replicons in Klebsiella pneumoniae Isolates from Powdered Milk Produced in Germany.
The study identified multiple AMR genes in K. pneumoniae isolates from powdered milk, including blaSHV variants, oqx genes, fosA, pmrB_R256G, and mcr-9. These genes conferred resistance to beta-lactams, chloramphenicol, quinolones, fosfomycin, and colistin. Despite some isolates carrying mcr-9, they remained susceptible to colistin.
WGS-Based Phenotyping and Molecular Characterization of the Resistome, Virulome and Plasmid Replicons in Klebsiella pneumoniae Isolates from Powdered Milk Produced in Germany.
The study identified multiple AMR genes in K. pneumoniae isolates from powdered milk, including blaSHV variants, oqx genes, fosA, pmrB_R256G, and mcr-9. These genes conferred resistance to beta-lactams, chloramphenicol, quinolones, fosfomycin, and colistin. Despite some isolates carrying mcr-9, they remained susceptible to colistin.
Isolation, Identification, Characterization, and Plasmid Profile of Urinary Tract Infectious Escherichia coli from Clinical Samples.
The study identified the presence of TEM, CTX-M, SHV, and OXA beta-lactamase genes in E. coli isolates, contributing to multidrug resistance, particularly to beta-lactam antibiotics.
Multidrug-Resistant Klebsiella pneumoniae Complex From Clinical Dogs and Cats in China: Molecular Characteristics, Phylogroups, and Hypervirulence-Associated Determinants.
The study identified multidrug-resistant Klebsiella pneumoniae complex isolates from clinical dogs and cats in China, highlighting the presence of various AMR genes such as bla SHV, bla CTX-M, bla NDM-5, aac(6')Ib-cr, qnrB, qnrS, oqxAB, aph(3')-Ia, aph(3')-Ib, bla OXA, bla DHA, bla LEN, and bla OKP.
Ultrafast and Cost-Effectiveness Pathogen Identification and Resistance Gene Detection in a Clinical Setting Using Nanopore Flongle Sequencing.
The study demonstrates the effectiveness of Oxford Nanopore Technology's Flongle sequencing for rapid bacterial identification and detection of antibiotic resistance genes (ARGs) in clinical settings. It identifies several beta-lactamase genes (TEM-1B, CTX-M-2, CTX-M-14, CTX-M-35, SHV-187) and other resistance genes (fosA, oqxA) in Escherichia coli and Klebsiella pneumoniae isolates.
Prevalence and Molecular Characterization of Extended Spectrum β-Lactamase and Carbapenemase-Producing Enterobacteriaceae Isolates from Bloodstream Infection Suspected Patients in Addis Ababa, Ethiopia.
The study identified bla CTX-M, bla SHV, bla TEM, and bla NDM genes as prevalent in Enterobacteriaceae isolates from bloodstream infections in Ethiopia, highlighting the significance of these genes in conferring resistance to beta-lactam antibiotics.
Inter-species geographic signatures for tracing horizontal gene transfer and long-term persistence of carbapenem resistance.
The study characterizes various carbapenem resistance genes such as blaKPC, blaNDM, blaOXA-48, blaVIM, blaIMP, blaGES, blaSIM, blaTEM, blaSHV, blaCTX-M, ampC, mecA, vanA, vanB, vanC, mcr-1, mcr-2, mcr-3, mcr-4, and mcr-5 in Enterobacterales and other bacterial species, highlighting their role in carbapenem resistance and horizontal gene transfer.
Piperacillin/tazobactam-resistant, cephalosporin-susceptible Escherichia coli bloodstream infections are driven by multiple acquisition of resistance across diverse sequence types.
The study identifies various beta-lactamase genes, including bla TEM-1, bla TEM-33, bla CTX-M-15, bla OXA-1, and bla SHV-1, as well as the S133G mutation in bla CTX-M-15, which contribute to piperacillin/tazobactam resistance in Escherichia coli bloodstream infections.
Large-Scale Genomic Epidemiology of Klebsiella pneumoniae Identified Clone Divergence with Hypervirulent Plus Antimicrobial-Resistant Characteristics Causing Within-Ward Strain Transmissions.
The study identified clone divergence in Klebsiella pneumoniae, particularly highlighting the emergence of hypervirulent plus antimicrobial-resistant (hv+AMR) subclones. Key AMR genes such as bla KPC-2, bla CTX-M-65, and others were characterized, along with virulence factors like rmpA, rmpA2, and ybt.
Community Fecal Carriage and Molecular Epidemiology of Extended-Spectrum β-Lactamase- and Carbapenemase-Producing Escherichia coli from Healthy Children in the Central South China.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, and others, as well as the carbapenemase gene bla NDM-1 in Escherichia coli isolates from healthy children in China. Additionally, the colistin resistance gene mcr-1 was detected in one ESBL-EC isolate.
Epidemiology of Klebsiella michiganensis Carrying Multidrug-Resistant IncHI5 Plasmids in the Southeast Coastal Area of China.
The study identified multiple AMR genes on IncHI5 plasmids in Klebsiella michiganensis, including beta-lactamases (blaCTX-M-3, blaTEM-1, blaSHV-12, blaIMP-4, blaNDM-1, blaOXA-1, blaOXA-16, blaSFO-1, blaSIM-1), aminoglycoside modifying enzymes (aacA4, arr3, aadA5, gcu37, dfrA1), chloramphenicol acetyltransferase (catA2), streptomycin resistance genes (strA, strB), macrolide resistance genes (msrAB, mph(A)), and quaternary ammonium compound resistance gene (qacG2).
Antimicrobial Resistance in Escherichia coli from the Broiler Farm Environment, with Detection of SHV-12-Producing Isolates.
The study identifies SHV-12-producing Escherichia coli isolates in a broiler farm environment, highlighting the presence of various antimicrobial resistance genes such as bla SHV-12, cmlA, tet (A), aac(6′)-Ib-cr, and others. These genes confer resistance to multiple antibiotics, emphasizing the need for monitoring and controlling AMR in agricultural settings.
TEM,CTX-M,SHV Genes in ESBL-Producing Escherichia coli and Klebsiella pneumoniae Isolated from Clinical Samples in a County Clinical Emergency Hospital Romania-Predominance of CTX-M-15.
The study identifies the prevalence of bla CTX-M-15, bla SHV-1, and bla TEM-1 genes in ESBL-producing E. coli and K. pneumoniae isolates, highlighting the dominance of CTX-M-15. It also detects tetracycline resistance genes tet(A) and tet(B).
β-Lactam Antibiotics and beta-lactamase Enzymes Inhibitors, Part 2: Our Limited Resources.
The paper reviews β-lactam antibiotics and beta-lactamase enzymes inhibitors, focusing on the mechanisms of resistance mediated by beta-lactamases such as TEM-1, SHV-1, KPC-2, OXA-48, and NDM-1, and highlights the need for new inhibitors to combat carbapenem-resistant bacteria.
Food Is Reservoir of MDR Salmonella: Prevalence of ESBLs Profiles and Resistance Genes in Strains Isolated from Food.
The study identified bla SHV, bla CTX-M, and bla TEM genes in ESBL-producing Salmonella strains isolated from food samples, highlighting the prevalence of multidrug-resistant Salmonella in food sources.
Urban Wildlife Crisis: Australian Silver Gull Is a Bystander Host to Widespread Clinical Antibiotic Resistance.
The study identifies multiple antibiotic resistance genes, including bla_IMP-4, bla_SHV-12, sul1, sul2, mphA, and floR, in Escherichia coli isolates from Australian silver gulls, highlighting the role of wildlife in the spread of clinical antibiotic resistance.
Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017.
The study identified several AMR genes in K. pneumoniae isolates, including bla CTX-M-15, bla SHV-27, bla SHV-1, bla SHV-101, bla SHV-108, bla TEM-1B, qnrB66, aac(3)-IIa, dfrA14, strA, strB, sul2, and tet(A). These genes conferred resistance to various antibiotics such as beta-lactams, quinolones, aminoglycosides, sulfonamides, and tetracyclines.
Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017.
The study identified several AMR genes in K. pneumoniae isolates, including bla CTX-M-15, bla SHV-27, bla SHV-1, bla SHV-101, bla SHV-108, bla TEM-1B, qnrB66, aac(3)-IIa, dfrA14, strA, strB, sul2, and tet(A). These genes conferred resistance to various antibiotics such as beta-lactams, quinolones, aminoglycosides, sulfonamides, and tetracyclines.
Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017.
The study identified several AMR genes in K. pneumoniae isolates, including bla CTX-M-15, bla SHV-27, bla SHV-1, bla SHV-101, bla SHV-108, bla TEM-1B, qnrB66, aac(3)-IIa, dfrA14, strA, strB, sul2, and tet(A). These genes conferred resistance to various antibiotics such as beta-lactams, quinolones, aminoglycosides, sulfonamides, and tetracyclines.
Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017.
The study identified several AMR genes in K. pneumoniae isolates, including bla CTX-M-15, bla SHV-27, bla SHV-1, bla SHV-101, bla SHV-108, bla TEM-1B, qnrB66, aac(3)-IIa, dfrA14, strA, strB, sul2, and tet(A). These genes conferred resistance to various antibiotics such as beta-lactams, quinolones, aminoglycosides, sulfonamides, and tetracyclines.
Characteristics of ST11 KPC-2-producing carbapenem-resistant hypervirulent Klebsiella pneumoniae causing nosocomial infection in a Chinese hospital.
The study identified ST11 KPC-2-producing carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) as the main type causing nosocomial infections in a Chinese hospital. Key resistance genes included bla KPC-2, bla CTX-M-65, bla SHV-11, bla SHV-12, and bla TEM-1, which conferred resistance to various beta-lactam antibiotics.
Characteristics of ST11 KPC-2-producing carbapenem-resistant hypervirulent Klebsiella pneumoniae causing nosocomial infection in a Chinese hospital.
The study identified ST11 KPC-2-producing carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) as the main type causing nosocomial infections in a Chinese hospital. Key resistance genes included bla KPC-2, bla CTX-M-65, bla SHV-11, bla SHV-12, and bla TEM-1, which conferred resistance to various beta-lactam antibiotics.
Bacterial diversity and the antimicrobial resistome in the southwestern highlands of Saudi Arabia.
The study identified 102 antimicrobial resistance genes (ARGs) in the soil microbiota of the southwestern highlands of Saudi Arabia, primarily associated with multidrug resistance, macrolide, tetracycline, glycopeptide, bacitracin, and beta-lactam antibiotic resistance. qPCR confirmed the detection of 18 clinically important ARGs.
Characterization of Antibiotic Resistant Coliform Bacteria and Resistance Genes Isolated from Samples of Smoothie Drinks and Raw Milk.
The study identified antibiotic-resistant coliform bacteria in smoothie drinks and raw milk, highlighting the presence of resistance genes such as bla OXA, bla TEM, and bla SHV, which confer resistance to beta-lactam antibiotics like ampicillin.
An Outbreak of ST859-K19 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae in a Chinese Teaching Hospital.
The study reports an outbreak of ST859-K19 carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) in a Chinese hospital, identifying several resistance and virulence genes, including blaKPC-2, blaTEM-1B, blaSHV-187, rmtB, qnrS1, fosA6, and various virulence factors.
Genome-wide identification of carbapenem-resistant Gram-negative bacterial (CR-GNB) isolates retrieved from hospitalized patients in Bihar, India.
The study identified several carbapenem-resistant genes, including bla CTX-M, bla SHV, bla TEM, bla OXA, bla NDM, and bla DIM, in Gram-negative bacterial isolates from Bihar, India. These genes were found to confer resistance to various antibiotics, highlighting the prevalence of carbapenem resistance in the region.
Prevalence of extended-spectrum β-lactamase-producing Enterobacterales in retail sheep meat from Zagazig city, Egypt.
The study identified bla CTX-M, bla TEM, and bla SHV genes in ESBL-producing E. coli isolates from retail sheep meat in Egypt, highlighting the prevalence of these resistance mechanisms.
Cefixime and cefixime-clavulanate for screening and confirmation of extended-spectrum beta-lactamases in Escherichia coli.
The study identified CTX-M, TEM, and SHV genes as the primary extended-spectrum beta-lactamase (ESBL) genes in E. coli isolates, with CTX-M being the most prevalent.
Molecular Characterization of ESBLs and QnrS Producers From Selected Enterobacteriaceae Strains Isolated From Commercial Poultry Production Systems in Kiambu County, Kenya.
The study identified several ESBL genes (bla TEM, bla CTX-M, bla OXA, bla SHV) and the QnrS gene in Enterobacteriaceae isolates from commercial poultry in Kenya, highlighting the prevalence of multidrug-resistant bacteria in poultry production systems.
Diarrhoeagenic E. coli occurrence and antimicrobial resistance of Extended Spectrum Beta-Lactamases isolated from diarrhoea patients attending health facilities in Accra, Ghana.
The study identified bla TEM, bla CTX-M, and bla SHV genes as the primary extended spectrum beta-lactamase (ESBL) genes in Enterobacteriaceae isolates from diarrheal patients in Ghana. These genes conferred resistance to cephalosporins such as ceftazidime and cefotaxime.
Genetic Diversity, Biofilm Formation, and Antibiotic Resistance of Pseudomonas aeruginosa Isolated from Cow, Camel, and Mare with Clinical Endometritis.
The study identified several beta-lactamase genes, including bla TEM, bla CTX-M, bla SHV, and bla VIM, in Pseudomonas aeruginosa isolates from cows, camels, and mares with endometritis. These genes contribute to resistance against various antibiotics, highlighting the emergence of multidrug-resistant strains.
Genomic Analysis of Multidrug-Resistant Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Strain Lacking the Hypermucoviscous Regulators (rmpA/rmpA2).
The study identified multiple antimicrobial resistance genes in a multidrug-resistant hypervirulent Klebsiella pneumoniae strain, including beta-lactamases, sulfonamide resistance genes, fosfomycin resistance genes, aminoglycoside resistance genes, and tetracycline resistance genes.
Antimicrobial Resistance and Virulence Characteristics of Klebsiella pneumoniae Isolates in Kenya by Whole-Genome Sequencing.
The study identified several AMR genes in K. pneumoniae isolates from Kenya, including blaCTX-M-15, blaTEM-181, blaOXA-181, blaNDM-1, mcr-8, armA, rmtF, aac(6')-Ib-cr, aph(3")-ib, aph(6)-id, dfrA, sul2, qnrB, tetA, and catII, which confer resistance to various antibiotics such as beta-lactams, carbapenems, aminoglycosides, fluoroquinolones, tetracyclines, and chloramphenicol.
In Vitro Activity and Clinical Efficacy of Faropenem against Third-Generation Cephalosporin-Resistant Escherichia coli and Klebsiella pneumoniae.
The study identified several beta-lactamase genes, including blaCTX-M-1, blaCTX-M-9, blaTEM, blaSHV, blaCIT, and blaDHA, which confer resistance to third-generation cephalosporins in Escherichia coli and Klebsiella pneumoniae. These genes were experimentally characterized through PCR and genotyping.
Molecular Analysis With 16S rRNA PCR/Sanger Sequencing and Molecular Antibiogram Performed on DNA Extracted From Valve Improve Diagnosis and Targeted Therapy of Infective Endocarditis: A Prospective Study.
The study highlights the effectiveness of molecular analysis (MA) combined with molecular antibiogram in improving the diagnosis and targeted therapy of infective endocarditis (IE), particularly in blood culture-negative cases. It shows that molecular antibiogram has high concordance with traditional antimicrobial susceptibility testing (AST) and can identify resistance genes such as aadA1, aacC1, AAC(6)-Ib-cr, QnrS, CTX-M-1 Group, SHV, KPC, and tetA.
Phenotyping and genotyping studies on extended-spectrum β-lactamase-producing Escherichia coli isolates from mastitic cows on dairy farms in Egypt.
The study identified blaTEM and blaSHV genes as the most prevalent extended-spectrum beta-lactamase (ESBL) genes in Escherichia coli isolates from mastitic cows in Egypt. These genes confer resistance to several beta-lactam antibiotics.
Diminished Susceptibility to Cefoperazone/Sulbactam and Piperacillin/Tazobactam in Enterobacteriaceae Due to Narrow-Spectrum beta-lactamases as Well as Omp Mutation.
The study identifies blaSHV-1, blaTEM-1B, blaOXY-1-3, and blaOXY-1-1 as narrow-spectrum beta-lactamases contributing to resistance to CSL and TZP in CRO-susceptible Enterobacteriaceae. Additionally, OmpK36, OmpK37, and OmpK35 mutations are linked to resistance mechanisms.
Epidemiological Characteristics of OXA-232-Producing Carbapenem-Resistant Klebsiella pneumoniae Strains Isolated during Nosocomial Clonal Spread Associated with Environmental Colonization.
The study identified OXA-232-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) strains that exhibited multidrug resistance, including resistance to carbapenems, cephalosporins, aminoglycosides, and quinolones. The strains were part of a clonal spread within the ICU, showing genetic similarities and carrying resistance genes such as blaOXA-232, blaCTX-M-15, blaSHV-106, and others.
Cross-Sectional Survey of Antibiotic Resistance in Extended Spectrum β-Lactamase-Producing Enterobacteriaceae Isolated from Pigs in Greece.
The study identified a high prevalence of ESBL-producing Enterobacteriaceae in Greek pigs, with a focus on resistance mechanisms involving bla CTX-M1/15, bla TEM, and bla SHV genes, as well as resistance to fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and colistin.
Companion Animals as Potential Reservoirs of Antibiotic Resistant Diarrheagenic Escherichia coli in Shandong, China.
The study identified several AMR genes in E. coli isolates from companion animals in Shandong, China, including blaCTX-M, blaSHV, aac(6')-Ib-cr, and qnrS, highlighting the presence of multidrug-resistant strains and the potential reservoir role of companion animals in AMR dissemination.
Retail chicken giblets contaminated with extended-spectrum cephalosporin- and carbapenem-resistant Salmonella enterica carrying blaCMY-2.
The study identified extended-spectrum cephalosporin- and carbapenem-resistant Salmonella enterica in retail chicken giblets, water tanks, and workers, carrying blaTEM, blaSHV, blaCMY-2, blaOXA-1, and blaKPC genes.
Extended-spectrum beta-lactamases among Klebsiella pneumoniae from Iraqi patients with community-acquired pneumonia.
The study identified bla CTX-M and bla SHV genes as the primary extended-spectrum beta-lactamase (ESBL) genes in Klebsiella pneumoniae isolates from Iraqi patients with community-acquired pneumonia. These genes conferred resistance to several beta-lactam antibiotics.
Assessment of multidrug-resistant Listeria monocytogenes in milk and milk product and One Health perspective.
The study identified multiple antimicrobial resistance genes in Listeria monocytogenes isolates from milk and milk products, including beta-lactamase genes (bla TEM, bla SHV, bla Z), tetracycline resistance genes (tet A, tet D, tet G, tet K, tet M), sulfonamide resistance genes (sul 1, sul 2), and an aminoglycoside resistance gene (aph (3)-IIa (aphA2)).
Prevalence and factors associated with faecal carriage of extended-spectrum beta-lactamase-producing Enterobacterales among peripartum women in the community in Cambodia.
The study identified a high prevalence of ESBL-producing Enterobacterales in peripartum women in Cambodia, with bla CTX-M-15, bla CTX-M-55, and bla CTX-M-27 being the most common ESBL genes. Additionally, bla NDM-1, bla NDM-5, and bla NDM-6 carbapenemase genes, as well as mcr-1 and mcr-3 colistin resistance genes, were detected in the isolates.
Prevalence and factors associated with faecal carriage of extended-spectrum beta-lactamase-producing Enterobacterales among peripartum women in the community in Cambodia.
The study identified a high prevalence of ESBL-producing Enterobacterales in peripartum women in Cambodia, with bla CTX-M-15, bla CTX-M-55, and bla CTX-M-27 being the most common ESBL genes. Additionally, bla NDM-1, bla NDM-5, and bla NDM-6 carbapenemase genes, as well as mcr-1 and mcr-3 colistin resistance genes, were detected in the isolates.
Extended-spectrum Beta-lactamases Encoding Genes among Salmonella Enterica serovar Typhi Isolates in Patients with Typhoid Fever from four Academic Medical Centers Lagos, Nigeria.
The study identified the presence of ESBL-harboring S. Typhi isolates in patients with typhoid fever from Nigeria, highlighting the emergence of multidrug-resistant strains with blaCTX-M, blaSHV, and blaTEM genes.
Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates.
The study identified various antimicrobial resistance genes and mutations in Klebsiella pneumoniae bloodstream isolates, highlighting the presence of multidrug-resistant and hypervirulent strains in the United States.
Using Targeted Liquid Chromatography-Tandem Mass Spectrometry to Rapidly Detect β-Lactam, Aminoglycoside, and Fluoroquinolone Resistance Mechanisms in Blood Cultures Growing E. coli or K. pneumoniae.
The study developed and validated a targeted LC-MS/MS assay for the rapid detection of β-lactam, aminoglycoside, and fluoroquinolone resistance mechanisms in blood cultures growing E. coli or K. pneumoniae. The assay successfully detected various resistance genes including beta-lactamases (SHV, TEM, CTX-M-1-like, OXA-1, CMY-2-like, cAmpC, KPC, OXA-48, NDM, VIM), aminoglycoside-modifying enzymes (AAC(3)-Ia, AAC(3)-II, AAC(3)-IV, AAC(3)-VI, AAC(6′)-Ib, ANT(2′′)-I, APH(3′)-VI), 16S-RMTases (ArmA, RmtB, RmtC, RmtF), and quinolone resistance mechanisms (QnrA, QnrB, AAC(6′)-Ib-cr, and wildtype QRDR of GyrA).
Prevalence and antimicrobial susceptibility profiles of ESBL-producing Klebsiella Pneumoniae from broiler chicken farms in Shandong Province, China.
The study identified bla SHV, bla NDM-1, and mcr-3 as the key antimicrobial resistance genes in ESBL-producing Klebsiella pneumoniae isolates from broiler chicken farms in Shandong, China. These genes conferred resistance to multiple antibiotics, including carbapenems and colistin.
Detection of Klebsiella pneumoniae antibiotic-resistant genes: An impending source of multidrug resistance dissemination through raw food.
The study identified several β-lactamase genes, including bla CTX-M, bla SHV, bla TEM, bla MOX, bla FOX, and carbapenemase genes such as bla NDM, bla IMP, bla VIM, and bla OXA-48, in Klebsiella pneumoniae isolates from raw food samples, highlighting the potential for multidrug resistance dissemination through the food chain.
Analysis of diverse β-lactamases presenting high-level resistance in association with OmpK35 and OmpK36 porins in ESBL-producing Klebsiella pneumoniae.
The study identifies various β-lactamase genes, including bla CTX-M−1, bla CTX-M−15, bla SHV-12, bla SHV-28, bla CYM-2, bla NDM-1, bla NDM-5, bla IMP, and integron-1, which contribute to high-level resistance in ESBL-producing K. pneumoniae. Additionally, the loss of OmpK35 and OmpK36 porins is associated with increased resistance.
Analysis of diverse β-lactamases presenting high-level resistance in association with OmpK35 and OmpK36 porins in ESBL-producing Klebsiella pneumoniae.
The study identifies various β-lactamase genes, including bla CTX-M−1, bla CTX-M−15, bla SHV-12, bla SHV-28, bla CYM-2, bla NDM-1, bla NDM-5, bla IMP, and integron-1, which contribute to high-level resistance in ESBL-producing K. pneumoniae. Additionally, the loss of OmpK35 and OmpK36 porins is associated with increased resistance.
First Report of bla (CTX-M-167), bla (SHV-1), and bla (TEM-1B) Carrying Klebsiella pneumonia Showing High-Level Resistance to Carbapenems.
The study identifies the first report of a carbapenem-resistant Klebsiella pneumoniae strain carrying bla CTX-M-167, bla TEM-1B, and bla SHV-1, along with other resistance genes such as qnrS1, aac(6')-1b-cr, aadA16, tet(A), fosA, sul1, and mph(A).
Molecular Characterization of Klebsiella pneumoniae Isolated from Sputum in a Tertiary Hospital in Xinxiang, China.
The study identified several AMR genes in K. pneumoniae isolates, including bla SHV, bla CTX-M, bla TEM, aac, qnr B, and oqx B, which contribute to resistance against beta-lactams, aminoglycosides, and quinolones. The presence of these genes highlights the severity of antibiotic resistance in the region.
Genomic Analysis of an I1 Plasmid Hosting a sul3-Class 1 Integron and bla(SHV-12) within an Unusual Escherichia coli ST297 from Urban Wildlife.
The study identifies a novel I1 plasmid in an Escherichia coli ST297 isolate from a silver gull, which carries the bla(SHV-12) gene and a sul3-class 1 integron. Both genes confer resistance to specific antibiotics.
Molecular mechanisms underlying bacterial resistance to ceftazidime/avibactam.
The study identifies various mutations in blaKPC-2, blaKPC-3, blaCTX-M-14, blaCTX-M-15, blaSHV-1, and blaAmpC genes that confer resistance to ceftazidime/avibactam. These mutations include amino acid substitutions and insertions/deletions affecting the enzyme's affinity for CAZ and AVI, leading to increased MIC values and resistance.
Multidrug-Resistant Enteropathogenic Escherichia coli Isolated from Diarrhoeic Calves, Milk, and Workers in Dairy Farms: A Potential Public Health Risk.
The study identified multiple AMR genes, including bla TEM, bla SHV, bla CTX-M-1, qnrA, qnrS, and bla VIM, in multidrug-resistant EPEC isolates from diarrhoeic calves, milk, and workers in Egyptian dairy farms.
Evaluation of canine raw food products for the presence of extended-spectrum beta-lactamase- and carbapenemase-producing bacteria of the order Enterobacterales.
The study identified ESBL-producing Enterobacterales in 10% of canine raw food products, primarily frozen ones, with bla CTX-M-27 being the most common ESBL gene detected.
A Selective Medium for Screening Ceftazidime/Avibactam Resistance in Carbapenem-Resistant Enterobacterales.
The study developed an SS CZA medium for screening CZA-resistant CRE isolates, demonstrating 100% sensitivity and specificity. The medium effectively distinguishes between CZA-resistant and -susceptible strains, with resistance determinants including blaNDM, blaKPC, blaCTX-M, blaTEM, blaSHV, blaOXA-23, blaIMP, and ampC.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
A novel, magnetic bead-based extraction method for the isolation of antimicrobial resistance genes with a case study in river water in Malawi.
The study presents a novel, magnetic bead-based extraction method called MagnaExtract for isolating antimicrobial resistance genes (ARGs) from river water. The method showed comparable or better performance than commercial kits in terms of DNA yield and detection of ARGs such as bla CTXM-1, bla CTXM-9, bla SHV, bla OXA-48, bla IMP, and bla KPC.
Occurrence and distribution of extended-spectrum beta-lactamase in clinical Escherichia coli isolates at Ho Teaching Hospital in Ghana.
The study identified blaTEM-1, blaCTXM-1, blaSHV-73, and TOHO-1 as the primary ESBL genes in E. coli isolates, with blaTEM-1 being the most prevalent. Multiple ESBL gene carriage was observed, indicating complex resistance mechanisms.
Within-farm dynamics of ESBL-producing Escherichia coli in dairy cattle: Resistance profiles and molecular characterization by long-read whole-genome sequencing.
The study identified multiple ESBL-encoding genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, and bla SHV-12, as well as carbapenemase gene bla NDM-1, in ESBL-producing E. coli isolates from dairy cattle farms. These genes were associated with resistance to various beta-lactam antibiotics. Additionally, several other AMR genes such as aadA2, ant(3")-Ia, aph(3')-Ia, dfrA12, sul3, cmlA1, and others were identified, contributing to resistance against aminoglycosides, trimethoprim, sulfamethoxazole, and chloramphenicol. Mutations in gyrA, parC, and parE were linked to fluoroquinolone resistance.
Rapid Detection of Beta-Lactamases Genes among Enterobacterales in Urine Samples by Using Real-Time PCR.
The study developed a real-time PCR system to detect beta-lactamase genes (blaSHV-12, blaTEM, blaCTX-M-15, blaCTX-M-9, blaCMY-2, blaOXA-48, and blaNDM-1) in Enterobacterales strains from urine samples, demonstrating high sensitivity and specificity.
Emergence of a Novel NDM-5-Producing Sequence Type 4523 Klebsiella pneumoniae Strain Causing Bloodstream Infection in China.
The study identifies a novel sequence type 4523 Klebsiella pneumoniae strain, ST4523, which is resistant to multiple antibiotics, including carbapenems, and carries the bla NDM-5 gene on a plasmid. The strain also possesses various other resistance genes on plasmids pSHX180-1 and pSHX180-NDM5.
Prevalence and Molecular Characterization of Extended-Spectrum β-Lactamases and AmpC β-lactamase-Producing Enterobacteriaceae among Human, Cattle, and Poultry.
The study identified blaSHV, blaTEM, blaCTX-M, blaFOX, blaDHA, and blaACC genes as the primary contributors to extended-spectrum beta-lactamase and AmpC beta-lactamase production in Enterobacteriaceae isolated from humans, cattle, and poultry in Egypt.
Comparative Analysis of Clinical and Genomic Characteristics of Hypervirulent Klebsiella pneumoniae from Hospital and Community Settings: Experience from a Tertiary Healthcare Center in India.
The study identified multiple AMR genes, including bla CTX-M-15, bla SHV, bla OXA, and bla NDM, in hypervirulent Klebsiella pneumoniae isolates from both hospital and community settings, highlighting the emergence of multidrug-resistant hvKp strains.
Broad-Spectrum Inhibitors against Class A, B, and C Type β-Lactamases to Block the Hydrolysis against Antibiotics: Kinetics and Structural Characterization.
The study identifies three novel broad-spectrum inhibitors (D63, D2148, and D2573) effective against class A, B, and C β-lactamases, demonstrating reduced MIC and improved enzyme inhibition compared to existing inhibitors like avibactam.
Molecular characterization and biofilm-formation analysis of Listeria monocytogenes, Salmonella spp., and Escherichia coli isolated from Brazilian swine slaughterhouses.
The study identified various antimicrobial resistance genes in E. coli and Salmonella Typhi isolates from Brazilian swine slaughterhouses, including ampC, blaSHV, cat1, clmA, MCR-1, MCR-3, tet(A), tet(B), tet(C), tet(M), and sulI. These genes conferred resistance to multiple antibiotics such as ampicillin, amoxicillin, chloramphenicol, tetracycline, doxycycline, colistin, and sulfonamide.
Resistance Phenotype and Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Nanjing Children's Hospital in Jiangsu Province, China.
The study identified several carbapenemase genes, including blaKPC-2, blaNDM-1, blaNDM-5, blaIMP-8, and blaOXA-181, as well as other resistance genes such as blaCTX-M, blaSHV-2, APH(3)-IB, APH(6)-ID, FosA5, tetC, qnrB1, and tetA, contributing to multidrug resistance in CRKP strains isolated from children in Nanjing, China.
WGS-Based Lineage and Antimicrobial Resistance Pattern of Salmonella Typhimurium Isolated during 2000-2017 in Peru.
The study identifies 63 different AMR genes in 90 S. Typhimurium isolates from Peru, including beta-lactamases (blaTEM-181, blaSHV-12, blaSHV-134, blaCTX-M-15), quinolone resistance genes (qnrB5, qnrB19, qnrE2), tetracycline resistance genes (tetA, tetD, tetR), sulfonamide resistance genes (sul3), dihydrofolate reductase (dfrA1, dfrA12), florfenicol resistance gene (floR), lincomycin resistance gene (linG), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aadA2), colistin resistance gene (mcr-1), and fosfomycin resistance gene (fosA3).
WGS-Based Lineage and Antimicrobial Resistance Pattern of Salmonella Typhimurium Isolated during 2000-2017 in Peru.
The study identifies 63 different AMR genes in 90 S. Typhimurium isolates from Peru, including beta-lactamases (blaTEM-181, blaSHV-12, blaSHV-134, blaCTX-M-15), quinolone resistance genes (qnrB5, qnrB19, qnrE2), tetracycline resistance genes (tetA, tetD, tetR), sulfonamide resistance genes (sul3), dihydrofolate reductase (dfrA1, dfrA12), florfenicol resistance gene (floR), lincomycin resistance gene (linG), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aadA2), colistin resistance gene (mcr-1), and fosfomycin resistance gene (fosA3).
Characterization of Carbapenemase-Producing Klebsiella pneumoniae Isolates from Two Romanian Hospitals Co-Presenting Resistance and Heteroresistance to Colistin.
The study identifies multiple AMR genes and mutations in carbapenemase-producing Klebsiella pneumoniae isolates, including bla NDM-1, bla OXA-48, and various aminoglycoside-modifying enzymes, as well as mutations in mgrB, gyrA, parC, and porin genes associated with colistin and fluoroquinolone resistance.
Occurrence of Antimicrobial-Resistant Escherichia coli in Marine Mammals of the North and Baltic Seas: Sentinels for Human Health.
The study identified antimicrobial-resistant Escherichia coli in marine mammals from the North and Baltic Seas, highlighting the presence of resistance genes such as blaTEM, strA, strB, aadA1, sul1, sul2, tet(A), tet(B), tet(D), qnrS, floR, catA1, blaOXA-1-like, blaSHV, and blaCMY-2.
Clinical Efficacy, Antibiotic Resistance Genes, Virulence Factors and Outcome of Hospital-Acquired Pneumonia Induced by Klebsiella pneumoniae Carbapenemase 2-Producing with Tigecycline Treatment in the ICU.
The study identified several antibiotic resistance genes, including blaKPC-2, blaSHV, blaCTX-M, blaTEM, and aac3iia, which are associated with resistance to various antibiotics. Additionally, virulence factors such as AREO-iutA and Capsule-wzc were found to be independently associated with mortality in patients with KPC-KP infections.
Adult intracranial infection caused by an extended-spectrum-beta-lactamase-producing strain of hypervirulent Klebsiella pneumoniae: a case report.
The case report describes an adult intracranial infection caused by an extended-spectrum-beta-lactamase (ESBL)-producing hypervirulent Klebsiella pneumoniae strain, which harbored the blaSHV gene, a member of the ESBL family that confers resistance to various beta-lactam antibiotics.
Phenotypic and genotypic detection of extended spectrum beta lactamase enzyme in Klebsiella pneumoniae.
The study identified blaSHV and blaTEM genes as the predominant ESBL genes in Klebsiella pneumoniae isolates, with blaSHV being more prevalent.
Molecular Characterization of Gene-Mediated Resistance and Susceptibility of ESKAPE Clinical Isolates to Cistus monspeliensis L. and Cistus salviifolius L. Extracts.
The study identified several AMR genes in ESKAPE clinical isolates, including bla CTX-M, bla SHV, bla OXA-48, bla NDM, bla OXA-51, bla OXA-58, bla IMP, bla VIM, bla mecA, and bla VanA, which confer resistance to various antibiotics.
Resistance and virulence features of hypermucoviscous Klebsiella pneumoniae from bloodstream infections: Results of a nationwide Italian surveillance study.
The study identified various AMR genes in hypermucoviscous Klebsiella pneumoniae isolates, including bla KPC-3, bla KPC-2, CMY-16, CTX-M-15, bla SHV-2, bla DHA-1, bla CTX-M-65, qnr, aadA1, aac(6')-Ib, sul1, dfrA1, mph(A), erm(B), floR, and fosA3. These genes conferred resistance to multiple antibiotics, including carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and fosfomycin.
Epidemiological characteristics an outbreak of ST11 multidrug-resistant and hypervirulent Klebsiella pneumoniae in Anhui, China.
Epidemiological characteristics an outbreak of ST11 multidrug-resistant and hypervirulent Klebsiella pneumoniae in Anhui, China.
Epidemiological characteristics an outbreak of ST11 multidrug-resistant and hypervirulent Klebsiella pneumoniae in Anhui, China.
Epidemiological characteristics an outbreak of ST11 multidrug-resistant and hypervirulent Klebsiella pneumoniae in Anhui, China.
Efficient Suppression of Natural Plasmid-Borne Gene Expression in Carbapenem-Resistant Klebsiella pneumoniae Using a Compact CRISPR Interference System.
The study demonstrates the effective use of a CRISPR interference (CRISPRi) system to suppress the expression of plasmid-borne resistance genes, specifically bla_NDM-1 and bla_SHV-12, in carbapenem-resistant Klebsiella pneumoniae, leading to reduced antibiotic resistance.
Investigating Antimicrobial Resistance and ESBL Producing Gene in Klebsiella Isolates among Neonates and Adolescents in Southern Bangladesh.
The study identified the blaSHV-11 gene in 38% of Kpn isolates, highlighting its role in multidrug resistance against beta-lactams and other antibiotics.
Whole genome sequencing of OXA-232-producing wzi93-KL112-O1 carbapenem-resistant Klebsiella pneumoniae in human bloodstream infection co-harboring chromosomal ISEcp1-based bla (CTX-M-15) and one rmpA2-associated virulence plasmid.
The study characterizes an OXA-232-producing ST15 CRKP strain with a multidrug-resistant profile, harboring chromosomal bla CTX-M-15 and plasmid-mediated bla OXA-232, along with other resistance genes such as strAB, rmtF, sul2, dfrA14, qnrB1, arr-2, and catB. Mutations in gyrA (S83F) and parC (S80I) contribute to fluoroquinolone resistance.
Whole genome sequencing of OXA-232-producing wzi93-KL112-O1 carbapenem-resistant Klebsiella pneumoniae in human bloodstream infection co-harboring chromosomal ISEcp1-based bla (CTX-M-15) and one rmpA2-associated virulence plasmid.
The study characterizes an OXA-232-producing ST15 CRKP strain with a multidrug-resistant profile, harboring chromosomal bla CTX-M-15 and plasmid-mediated bla OXA-232, along with other resistance genes such as strAB, rmtF, sul2, dfrA14, qnrB1, arr-2, and catB. Mutations in gyrA (S83F) and parC (S80I) contribute to fluoroquinolone resistance.
Prevalence, antibiotic profile, virulence determinants, ESBLs, and non-β-lactam encoding genes of MDR Proteus spp. isolated from infected dogs.
The study identified multiple AMR genes in MDR Proteus spp. isolated from dogs, including bla TEM, bla SHV, bla CTX-M, bla OXA-1, sul1, tetA, aadA1, qnrA, intI1, ure C, zap A, and rsb A. These genes conferred resistance to various antibiotics such as penicillins, cephalosporins, sulfonamides, tetracyclines, quinolones, and aminoglycosides.
Human pandemic K27-ST392 CTX-M-15 extended-spectrum beta-lactamase-positive Klebsiella pneumoniae: A one health clone threatening companion animals.
The study identifies a multidrug-resistant K. pneumoniae strain (LCKp01) carrying the bla CTX-M-15 gene and other clinically important AMR genes, highlighting the global spread of this clone in both human and animal populations.
Antimicrobial Resistance Pattern, Clustering Mechanisms and Correlation Matrix of Drug-Resistant Escherichia coli in Black Bengal Goats in West Bengal, India.
The study identified several AMR genes in multidrug-resistant E. coli isolates from goats, including bla CTXM-1, bla AmpC, bla SHV, bla TEM, bla CMY-6, bla CITM, bla NDM-5, qnr B, qnr S, aac(6')-Ib-cr, tet A, tet B, sul 1, and the acrAB efflux pump system.
Urban Pigeons (Columba livia) as a Source of Broad-Spectrum beta-lactamase-Producing Escherichia coli in Lisbon, Portugal.
The study identified ESBL-producing E. coli in urban pigeons in Lisbon, Portugal, carrying bla CTX-M-15, bla CTX-M-27, and bla SHV-12 genes, which confer resistance to various β-lactam antibiotics.
Antibiotic Susceptibility Profiles and Resistance Mechanisms to β-Lactams and Polymyxins of Escherichia coli from Broilers Raised under Intensive and Extensive Production Systems.
The study identifies several β-lactamase genes, including SHV-12, CTX-M group variants, TEM, OXA, and PMAβ, as well as the mcr-1 gene responsible for polymyxin resistance in E. coli isolates from broilers raised in intensive and extensive systems. The prevalence of reduced susceptibility to antibiotics is higher in isolates from the intensive system.
Whole genome sequencing and characteristics of extended-spectrum beta-lactamase producing Escherichia coli isolated from poultry farms in Banaskantha, India.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla TEM, bla SHV, bla OXA, and bla CTX-M subtypes, along with plasmid-mediated AMR genes such as qnrS1, tetA, dfrA14, sul2, aph(3")-lb, aph(6)-ld, and Aph(3')-la in ESBL-producing E. coli isolates from poultry farms in India.
Occurrence of Pseudomonas lactis and Pseudomonas paralactis Amongst Non-Lactose-Fermenting Bacterial Isolates in Chickens and Their Antimicrobial Resistance Patterns.
The study identified Pseudomonas lactis and Pseudomonas paralactis in chicken fecal samples and characterized their antimicrobial resistance genes including aac(6')-lb-cr, blaCTX-M, blaSHV, and qnrS.
The Impact of Chlorine Disinfection of Hospital Wastewater on Clonal Similarity and ESBL-Production in Selected Bacteria of the Family Enterobacteriaceae.
Chlorine-based disinfection promotes the survival of ESBL-producing bacteria and/or the transmission of genetic determinants of AMR, increasing the proportion of ESBL-producing Enterobacteriaceae in disinfected wastewater.
Dissemination of High-Risk Clones Enterobacterales among Bulgarian Fecal Carriage Isolates.
The study identified several AMR genes, including bla CTX-M-15, bla CTX-M-3, bla CTX-M-27, bla CTX-M-14, bla CTX-M-9, bla SHV-1, bla SHV-11, bla TEM-1, bla NDM-1, bla KPC-2, bla CMY-4, bla DHA-1, and bla CMY-2, which confer resistance to various beta-lactam antibiotics. High-risk clones such as ST11, ST258, and ST15 were found to be prevalent among Klebsiella pneumoniae isolates, while ST131 was the most common among E. coli isolates.
Dissemination of High-Risk Clones Enterobacterales among Bulgarian Fecal Carriage Isolates.
The study identified several AMR genes, including bla CTX-M-15, bla CTX-M-3, bla CTX-M-27, bla CTX-M-14, bla CTX-M-9, bla SHV-1, bla SHV-11, bla TEM-1, bla NDM-1, bla KPC-2, bla CMY-4, bla DHA-1, and bla CMY-2, which confer resistance to various beta-lactam antibiotics. High-risk clones such as ST11, ST258, and ST15 were found to be prevalent among Klebsiella pneumoniae isolates, while ST131 was the most common among E. coli isolates.
A First Report of Molecular Typing, Virulence Traits, and Phenotypic and Genotypic Resistance Patterns of Newly Emerging XDR and MDR Aeromonas veronii in Mugil seheli.
The study identified XDR and MDR Aeromonas veronii strains in Mugil seheli carrying resistance genes bla TEM, bla CTX-M, bla SHV, tet A, aad A1, and sul 1.
Identification of KPC-112 from an ST15 Klebsiella pneumoniae Strain Conferring Resistance to Ceftazidime-Avibactam.
The study identifies a novel KPC variant, KPC-112, which confers resistance to ceftazidime-avibactam. Additionally, various other resistance genes and mutations were characterized, contributing to multidrug resistance in the isolate.
Conjugative transfer of multi-drug resistance IncN plasmids from environmental waterborne bacteria to Escherichia coli.
The study identified the transfer of multi-drug resistance IncN plasmids from environmental waterborne bacteria to E. coli, highlighting the presence of sulfonamide resistance genes sul1 and sul2 in transconjugants.
Antimicrobial resistance and genomic characterization of Salmonella enterica serovar Senftenberg isolates in production animals from the United States.
The study characterized antimicrobial resistance genes and mutations in Salmonella enterica serovar Senftenberg isolates from production animals in the United States, identifying genes such as aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, blaTEM-1B, blaCMY-2, blaSHV-12, floR, catA2, qnrB2, aac(6')-Ib-cr, aadA1, aadA2, sul1, sul2, tetA, and mcr-9.1, along with mutations in gyrA and parC genes contributing to resistance against various antibiotics.
Prevalence of extended spectrum Beta-Lactamase producing Klebsiella species from patients' specimens in a tertiary teaching hospital in Ile-Ife, Southwest Nigeria.
The study identified blaSHV, blaTEM, and blaCTX-M as the most prevalent ESBL genes in Klebsiella isolates, with blaSHV being the most common.
A large-scale genomic snapshot of Klebsiella spp. isolates in Northern Italy reveals limited transmission between clinical and non-clinical settings.
A large-scale genomic snapshot of Klebsiella spp. isolates in Northern Italy reveals limited transmission between clinical and non-clinical settings.
A large-scale genomic snapshot of Klebsiella spp. isolates in Northern Italy reveals limited transmission between clinical and non-clinical settings.
A large-scale genomic snapshot of Klebsiella spp. isolates in Northern Italy reveals limited transmission between clinical and non-clinical settings.
A large-scale genomic snapshot of Klebsiella spp. isolates in Northern Italy reveals limited transmission between clinical and non-clinical settings.
A large-scale genomic snapshot of Klebsiella spp. isolates in Northern Italy reveals limited transmission between clinical and non-clinical settings.
Occurrence of Antibiotic Resistant Bacteria in Flours and Different Plant Powders Used in Cuisine.
The study identified the presence of antibiotic-resistant coliform bacteria and enterococci in flour, plant powders, and dough samples. The blaSHV, tetA, and tetE genes were detected in isolates, indicating resistance to ampicillin and tetracycline. Enterococci were less prevalent compared to coliform bacteria and were found only in non-cereal flours.
Isolation, Identification, and Genetic Characterization of Antibiotic Resistance of Salmonella Species Isolated from Chicken Farms.
The study identified several AMR genes in Salmonella isolates from chicken farms in Egypt, including blaTEM, blaSHV, ermB, ereA, and mphA, which conferred resistance to ampicillin, erythromycin, and lincomycin.
Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America.
The study identified and characterized several extended-spectrum cephalosporin resistance (ESC-R) genes, including bla CTX-M-1, bla CTX-M-15, bla CMY-2, bla CTX-M-14, and bla SHV-12, in Escherichia coli isolates from Europe and North America. These genes were found to be prevalent in different geographical regions and sources, with varying frequencies and distributions.
Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae in a Tertiary Hospital in Northern China.
The study identified bla KPC-2, bla GES, bla NDM-1, and bla IMP as the main carbapenemase genes in CRKP isolates. Additionally, various ESBL genes, aminoglycoside resistance genes, and PMQR genes were detected.
Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae in a Tertiary Hospital in Northern China.
The study identified bla KPC-2, bla GES, bla NDM-1, and bla IMP as the main carbapenemase genes in CRKP isolates. Additionally, various ESBL genes, aminoglycoside resistance genes, and PMQR genes were detected.
Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae in a Tertiary Hospital in Northern China.
The study identified bla KPC-2, bla GES, bla NDM-1, and bla IMP as the main carbapenemase genes in CRKP isolates. Additionally, various ESBL genes, aminoglycoside resistance genes, and PMQR genes were detected.
Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae in a Tertiary Hospital in Northern China.
The study identified bla KPC-2, bla GES, bla NDM-1, and bla IMP as the main carbapenemase genes in CRKP isolates. Additionally, various ESBL genes, aminoglycoside resistance genes, and PMQR genes were detected.
Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae in a Tertiary Hospital in Northern China.
The study identified bla KPC-2, bla GES, bla NDM-1, and bla IMP as the main carbapenemase genes in CRKP isolates. Additionally, various ESBL genes, aminoglycoside resistance genes, and PMQR genes were detected.
In Vitro Assessment of Antimicrobial Activity of Phytobiotics Composition towards of Avian Pathogenic Escherichia coli (APEC) and Other E. coli Strains Isolated from Broiler Chickens.
The study identifies several AMR genes in E. coli strains, including aadA, strA/strB, aphA1, aphA2, tetA, tetB, sul1, sul2, sul3, dfrA1, dfrA10, dfrA12, floR, and blaSHV, which confer resistance to various antibiotics such as streptomycin, neomycin, tetracycline, sulfonamides, trimethoprim, chloramphenicol, and cephalosporins.
First Report of Potentially Pathogenic Klebsiella pneumoniae from Serotype K2 in Mollusk Tegillarca granosa and Genetic Diversity of Klebsiella pneumoniae in 14 Species of Edible Aquatic Animals.
The study reports the presence of tetracycline resistance in Klebsiella pneumoniae isolates from various aquatic animals, highlighting the potential risk of antimicrobial resistance in food sources.
Intestinal colonization with ESBL-producing Klebsiella pneumoniae in healthy rural villager: A genomic surveillance study in China, 2015-2017.
The study identified multiple ESBL genes, including bla TEM-1B, bla CTX-M-14, and bla SHV-11, along with other resistance genes such as qnrS1, sul1, aac(6')-Ib-cr, aadA16, aph(3')-Ib, tet(A), and mcr-1, contributing to multidrug resistance in ESBL-producing Klebsiella pneumoniae isolates from healthy rural villagers in China.
Genotypic characterization of extended-spectrum beta-lactamase producing urinary isolates among pregnant women in Ho municipality, Ghana.
The study identified bla TEM, bla CTX-M, and bla SHV genes as the primary mechanisms of extended-spectrum beta-lactamase (ESBL) production in urinary isolates from pregnant women in Ho municipality, Ghana.
Evidence of Sharing of Carbapenem-Resistant Klebsiella pneumoniae Strains Between Intensive Care Unit Patients and the Environment.
The study identifies bla OXA-48, bla SHV, bla TEM, and bla NDM-1 as the primary carbapenem resistance genes in CR-KP strains isolated from ICU patients and the environment, highlighting the potential for environmental transmission of these strains.
A scoping review of the distribution and frequency of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in shrimp and salmon.
The study identifies various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-9, bla TEM, bla SHV, and bla CTX-M-55, in Enterobacteriaceae isolated from shrimp and salmon. These genes confer resistance to multiple β-lactam antibiotics.
Genotypic and Phenotypic Characterization of Pathogenic Escherichia coli, Salmonella spp., and Campylobacter spp., in Free-Living Birds in Mainland Portugal.
The study identified various AMR genes in pathogenic E. coli, Salmonella, and Campylobacter isolates from free-living birds in Portugal, including ESBL genes like bla CTX-M-15, bla SHV-12, bla SHV-55, and bla CTX-M-1, as well as tetracycline resistance gene tetO and aac(6')-Iaa. Additionally, a mutation in gyrA (gyrA_T86I) was found to confer fluoroquinolone resistance.
Genotypic and Phenotypic Characterization of Pathogenic Escherichia coli, Salmonella spp., and Campylobacter spp., in Free-Living Birds in Mainland Portugal.
The study identified various AMR genes in pathogenic E. coli, Salmonella, and Campylobacter isolates from free-living birds in Portugal, including ESBL genes like bla CTX-M-15, bla SHV-12, bla SHV-55, and bla CTX-M-1, as well as tetracycline resistance gene tetO and aac(6')-Iaa. Additionally, a mutation in gyrA (gyrA_T86I) was found to confer fluoroquinolone resistance.
Five-Hour Detection of Intestinal Colonization with Extended-Spectrum-beta-lactamase-Producing Enterobacteriaceae Using the β-Lacta Phenotypic Test: the BLESSED Study.
The study developed the BLESSED protocol for rapid detection of intestinal colonization with ESBL-PE, demonstrating high sensitivity and specificity. It identified various CTX-M and TEM-type beta-lactamase genes in ESBL-PE strains.
Five-Hour Detection of Intestinal Colonization with Extended-Spectrum-beta-lactamase-Producing Enterobacteriaceae Using the β-Lacta Phenotypic Test: the BLESSED Study.
The study developed the BLESSED protocol for rapid detection of intestinal colonization with ESBL-PE, demonstrating high sensitivity and specificity. It identified various CTX-M and TEM-type beta-lactamase genes in ESBL-PE strains.
Isolation, Identification and Genetic Characterization of Antibiotic Resistant Escherichia coli from Frozen Chicken Meat Obtained from Supermarkets at Dhaka City in Bangladesh.
The study identified several antimicrobial resistance genes in E. coli isolates from frozen chicken meat, including tet(A), tet(B), aadA1, aac(3)-IV, ereA, blaCITM, blaSHV, sulI, catA1, and cmlA, which confer resistance to tetracycline, streptomycin, gentamicin, erythromycin, ampicillin, sulfonamide, and chloramphenicol.
Multidrug-Resistant ESBL-Producing E. coli in Clinical Samples from the UK.
The study identified several β-lactamase genes (bla CTX-M, bla TEM, bla OXA-1) and integron-related genes (intl1, merA, merC) associated with multidrug resistance in ESBL-producing E. coli isolates from the UK.
Exploring broilers and native fowls of Andaman and Nicobar Islands as a source of beta-lactamase-producing Enterobacteriaceae even with limited anthropogenic activities and docking-based identification of catalytic domains in novel beta-lactamase variants.
The study identified several beta-lactamase genes, including bla TEM-1, bla SHV-11, bla SHV-27, bla SHV-228, bla CTX-M-15, and bla AmpC, in Enterobacteriaceae isolates from broilers and native fowls in the Andaman and Nicobar Islands. These genes were found to confer resistance to various β-lactam antibiotics.
Exploring broilers and native fowls of Andaman and Nicobar Islands as a source of beta-lactamase-producing Enterobacteriaceae even with limited anthropogenic activities and docking-based identification of catalytic domains in novel beta-lactamase variants.
The study identified several beta-lactamase genes, including bla TEM-1, bla SHV-11, bla SHV-27, bla SHV-228, bla CTX-M-15, and bla AmpC, in Enterobacteriaceae isolates from broilers and native fowls in the Andaman and Nicobar Islands. These genes were found to confer resistance to various β-lactam antibiotics.
Exploring broilers and native fowls of Andaman and Nicobar Islands as a source of beta-lactamase-producing Enterobacteriaceae even with limited anthropogenic activities and docking-based identification of catalytic domains in novel beta-lactamase variants.
The study identified several beta-lactamase genes, including bla TEM-1, bla SHV-11, bla SHV-27, bla SHV-228, bla CTX-M-15, and bla AmpC, in Enterobacteriaceae isolates from broilers and native fowls in the Andaman and Nicobar Islands. These genes were found to confer resistance to various β-lactam antibiotics.
Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009-2018.
The study identifies multiple AMR genes associated with multidrug-resistant Salmonella enterica serotype 4,[5],12:i:-, including genes conferring resistance to ampicillin, streptomycin, sulfamethoxazole, tetracycline, ciprofloxacin, ceftriaxone, azithromycin, and colistin. These genes are prevalent in a multidrug-resistant clade linked to pork consumption.
Finding of extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales in wild game meat originating from several European countries: predominance of Moellerella wisconsensis producing CTX-M-1, November 2021.
The study identified ESBL-producing Enterobacterales in wild game meat, with a significant prevalence of Moellerella wisconsensis producing CTX-M-1 and CTX-M-32, and Escherichia coli producing SHV-12.
Characterization of Escherichia coli and Other Enterobacterales Resistant to Extended-Spectrum Cephalosporins Isolated from Dairy Manure in Ontario, Canada.
The study identified bla CTX-M and bla CMY genes as major contributors to extended-spectrum cephalosporin resistance in Escherichia coli and other Enterobacterales isolated from dairy manure in Ontario, Canada. These genes were found to be prevalent in various plasmid types and were associated with multidrug resistance.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Evaluation of in-vitro susceptibility of ß-lactam-resistant Gram-negative bacilli to ceftazidime-avibactam and ceftolozane-tazobactam from clinical samples of a general hospital in southern Brazil.
The study identified bla CTX-M, bla SHV, bla KPC, bla NDM-1, and bla VIM as the primary β-lactamase genes responsible for resistance to ceftazidime-avibactam and ceftolozane-tazobactam in β-lactam-resistant Gram-negative bacilli.
Phylogenetic analysis and antibiotic resistance of Escherichia coli isolated from wild and domestic animals at an agricultural land interface area of Salaphra wildlife sanctuary, Thailand.
The study identified several AMR genes in E. coli isolates from wild and domestic animals in Thailand, including blaTEM, blaSHV, blaCMY-2, aac(3)-IV, aadA, tetA, tetB, qnrA, sul3, dfrA1, dfrA5, and dfrA7, which conferred resistance to various antibiotics such as ampicillin, gentamicin, tetracycline, ciprofloxacin, and trimethoprim-sulfamethoxazole.
Bacteriological characteristics of hypervirulent Klebsiella pneumoniae rmpA gene (hvKp-rmpA)-harboring strains in the south of Iran.
The study identified bla SHV and bla CTX-M as prevalent ESBL genes in cKp isolates, while hvKp- rmpA + strains exhibited lower antibiotic resistance compared to cKp isolates. Additionally, bla NDM was detected in 7.8% of cKp isolates.
Trends of β-Lactamase Occurrence Among Escherichia coli and Klebsiella pneumoniae in United States Hospitals During a 5-Year Period and Activity of Antimicrobial Agents Against Isolates Stratified by β-Lactamase Type.
The study identified various β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-27, bla SHV-12, bla SHV-7, bla SHV-27, bla TEM-1, bla TEM-12, bla CMY-2, bla DHA-1, bla FOX-5, bla OXA-1, bla OXA-1-like, bla KPC-2, bla KPC-3, bla NDM-1, bla NDM-5, bla OXA-181, bla OXA-48, and bla OXA-232, which confer resistance to β-lactam antibiotics. The study also found that CTX-M-15 was the most prevalent β-lactamase gene, and there was a notable increase in ESBL-producing isolates among K. pneumoniae.
Trends of β-Lactamase Occurrence Among Escherichia coli and Klebsiella pneumoniae in United States Hospitals During a 5-Year Period and Activity of Antimicrobial Agents Against Isolates Stratified by β-Lactamase Type.
The study identified various β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-27, bla SHV-12, bla SHV-7, bla SHV-27, bla TEM-1, bla TEM-12, bla CMY-2, bla DHA-1, bla FOX-5, bla OXA-1, bla OXA-1-like, bla KPC-2, bla KPC-3, bla NDM-1, bla NDM-5, bla OXA-181, bla OXA-48, and bla OXA-232, which confer resistance to β-lactam antibiotics. The study also found that CTX-M-15 was the most prevalent β-lactamase gene, and there was a notable increase in ESBL-producing isolates among K. pneumoniae.
Trends of β-Lactamase Occurrence Among Escherichia coli and Klebsiella pneumoniae in United States Hospitals During a 5-Year Period and Activity of Antimicrobial Agents Against Isolates Stratified by β-Lactamase Type.
The study identified various β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-27, bla SHV-12, bla SHV-7, bla SHV-27, bla TEM-1, bla TEM-12, bla CMY-2, bla DHA-1, bla FOX-5, bla OXA-1, bla OXA-1-like, bla KPC-2, bla KPC-3, bla NDM-1, bla NDM-5, bla OXA-181, bla OXA-48, and bla OXA-232, which confer resistance to β-lactam antibiotics. The study also found that CTX-M-15 was the most prevalent β-lactamase gene, and there was a notable increase in ESBL-producing isolates among K. pneumoniae.
In silico analyses of diversity and dissemination of antimicrobial resistance genes and mobile genetics elements, for plasmids of enteric pathogens.
The study identifies a diverse array of antimicrobial resistance (AMR) genes across various plasmid replicon types in enteric pathogens, highlighting the prevalence of resistance genes in plasmids such as IncHI2, IncN, IncA/C, IncP, IncHI1, and IncFIA. Key AMR genes include aac(3)-IId, aac(3)-IIg, aac(6')-Ib3, aadA1, aadA5, aph(3'')-Ib, bla CMY-2, bla CTX-M-27, bla NDM-1, mcr-9.1, and others, which confer resistance to antibiotics such as gentamicin, cephalosporins, carbapenems, colistin, and tetracycline.
Prevalence of extended spectrum beta lactamase and molecular detection of blaTEM, blaSHV and blaCTX-M genotypes among Gram negative bacilli isolates from pediatric patient population in Gaza strip.
The study identified blaTEM, blaSHV, and blaCTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) resistance in Gram-negative bacilli from pediatric patients in Gaza strip. These genes were prevalent among various bacterial species, with blaCTX-M being the most dominant.
Relationship Between Drug Resistance Characteristics and Biofilm Formation in Klebsiella Pneumoniae Strains.
The study identified ESBL genes blaTEM, blaSHV, and blaCTX-M in Klebsiella pneumoniae strains, which confer resistance to various beta-lactam antibiotics. Additionally, virulence genes such as rmpA, fimH, mrkD, entB, ybtS, allS, and kfu were found to be associated with hypervirulent K. pneumoniae strains.
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.
The study identified various AMR genes in sepsis-causing bacteria, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others, highlighting the complexity of AMR in these pathogens.
Occurrence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in raw milk from cows with subclinical mastitis in northeast Brazil.
The study identified ESBL-producing Enterobacteriaceae in raw milk from cows with subclinical mastitis in northeast Brazil, highlighting the presence of blaSHV and blaTEM genes.
Antimicrobial Peptides Designed against the Ω-Loop of Class A beta-lactamases to Potentiate the Efficacy of β-Lactam Antibiotics.
Six histidine-based pentapeptides (TSHLH, ETHIH, ESRLH, ESHIH, ESRIH, and TYHLH) were found to inhibit class A beta-lactamases (TEM-1 and SHV-14), enhancing the efficacy of β-lactam antibiotics against Gram-negative and acid-fast bacteria.
Investigating Catheter-Related Infections in Southern Benin Hospitals: Identification, Susceptibility, and Resistance Genes of Involved Bacterial Strains.
The study identified several beta-lactam resistance genes, including bla TEM, bla SHV, bla CTX-M-1, bla CTX-M-15, and bla NDM, in bacterial strains causing catheter-related infections in southern Benin hospitals.
Characterization of cephalosporin and fluoroquinolone resistant Enterobacterales from Irish farm waste by whole genome sequencing.
The study identified several beta-lactamase genes (bla CTX-M-14, bla CTX-M-15, bla CMY-2, bla SHV-12, and bla ACT-14) and a quinolone resistance gene (qnr S1) associated with cephalosporin and fluoroquinolone resistance in Enterobacterales from Irish farm waste. Additionally, mutations in gyr A, par C, and par E were linked to fluoroquinolone resistance.
High frequency of NDM-1 and OXA-48 carbapenemase genes among Klebsiella pneumoniae isolates in central Iran.
The study identified high frequencies of bla TEM, bla CTX-M1, bla SHV, bla CTX-M15, bla CIT, bla CMY-2, bla NDM, bla OXA-48, qnrB, qnrS, qnrA, tetA, tetB, sul1, sul2, int1, and int2 genes in Klebsiella pneumoniae isolates from central Iran, highlighting the prevalence of multidrug-resistant and carbapenem-resistant strains.
The Characteristics of Extended-Spectrum beta-lactamases (ESBLs)-Producing Escherichia coli in Bloodstream Infection.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M, bla TEM, bla SHV, bla OXA-1, and the colistin resistance gene mcr-1, in ESBL-producing Escherichia coli strains causing bloodstream infections.
Prevalence and molecular analysis of antibiotic resistance of Pseudomonas aeruginosa isolated from clinical and environmental specimens in Basra, Iraq.
The study identified several beta-lactamase genes, including bla SHV-2a, bla CTX-M-28, bla OXA-677, bla PER, and bla VEB-2, which contribute to multidrug resistance in Pseudomonas aeruginosa isolates from Basra, Iraq.
High prevalence of β-lactam and fluoroquinolone resistance in various phylotypes of Escherichia coli isolates from urinary tract infections in Jiroft city, Iran.
The study identified a high prevalence of β-lactam resistance genes (bla TEM, bla CTX-M, bla SHV, and bla CMY) and fluoroquinolone resistance in E. coli isolates from urinary tract infections in Jiroft, Iran. The most common resistance patterns were observed in phylotypes B2 and D.
Genetic characterization of ESBL-producing and ciprofloxacin-resistant Escherichia coli from Belgian broilers and pigs.
The study identified various ESBL genes such as bla CTX-M-1, bla CTX-M-32, bla CTX-M-15, bla SHV-12, bla TEM-52C, and bla TEM-52B, as well as PMQR genes like qnrS1 and qnrB19, in ESBL-producing and ciprofloxacin-resistant E. coli from Belgian broilers and pigs. Additionally, colistin resistance genes mcr-1.1, mcr-2.1, and mcr-9 were detected. Mutations in gyrA (S83L, D87N) and parC (S80I) were strongly associated with fluoroquinolone resistance.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
Occurrence of High-Risk Clonal Lineages ST58, ST69, ST224, and ST410 among Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated from Healthy Free-Range Chickens (Gallus gallus domesticus) in a Rural Region in Tunisia.
The study identified high-risk clonal lineages ST58, ST69, ST224, and ST410 among ESBL-producing E. coli isolates from free-range chickens in Tunisia. Key AMR genes included bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, aac(6')-Ib-cr, qnrS, qnrB, tetB, tetA, sul1, sul2, and mcr-2.
Occurrence of High-Risk Clonal Lineages ST58, ST69, ST224, and ST410 among Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated from Healthy Free-Range Chickens (Gallus gallus domesticus) in a Rural Region in Tunisia.
The study identified high-risk clonal lineages ST58, ST69, ST224, and ST410 among ESBL-producing E. coli isolates from free-range chickens in Tunisia. Key AMR genes included bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, aac(6')-Ib-cr, qnrS, qnrB, tetB, tetA, sul1, sul2, and mcr-2.
Investigating Possible Interspecies Communication of Plasmids Associated with Transfer of Third-Generation Cephalosporin, Quinolone, and Colistin Resistance Between Simultaneously Isolated Escherichia Coli and Klebsiella Pneumoniae.
The study identified multiple AMR genes in E. coli and K. pneumoniae isolates, including bla CTX-M-14, qnrS1, mcr-1.1, and others, highlighting the role of plasmids in the transfer of resistance genes between species.
Molecular epidemiology and comparative genomics of carbapenemase-producing Escherichia coli isolates from 19 tertiary hospitals in China from 2019 to 2020.
The study identified blaNDM-5, blaNDM-1, and blaNDM-7 as the primary carbapenemase genes in carbapenem-resistant Escherichia coli isolates. Additionally, blaSHV-12 and blaCTX-M were found to contribute to resistance against cephalosporins.
Antimicrobial resistance and molecular characterization of Klebsiella species causing bovine mastitis in Nghe An province, Vietnam.
The study identified multidrug-resistant Klebsiella spp. isolates from bovine mastitis cases in Vietnam, carrying genes such as acrA Kp, blaSHV, and tetA, which confer resistance to various antibiotics.
Plasmid-mediated colistin resistance among human clinical Enterobacterales isolates: national surveillance in the Czech Republic.
The study identified mcr-1, mcr-4, and mcr-9 genes in colistin-resistant Enterobacterales isolates from the Czech Republic, highlighting their association with plasmid-mediated resistance and multidrug resistance features.
High prevalence of bla(CTX-M-15) type extended-spectrum beta-lactamases in Gambian hooded vultures (Necrosyrtes monachus): A threatened species with substantial human interaction.
The study identified a high prevalence of bla(CTX-M-15) encoding extended-spectrum beta-lactamases in ESBL-producing E. coli isolates from hooded vultures in the Gambia, highlighting their potential role as bioindicators for antibiotic-resistant bacteria in anthropogenic-affected environments.
Molecular Characterization of the Convergent Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae Strain K1-ST23, Collected in Chile during the COVID-19 Pandemic.
The study identified carbapenem-resistant hypervirulent Klebsiella pneumoniae strain K-2157, which harbors multiple AMR genes including blaSHV-190, blaTEM-1, blaOXA-9, blaKPC-2, fosA, oqxA, and oqxB, along with virulence-associated plasmids and an integrative and conjugative element (ICE).
Development and evaluation of a centrifugal disk system for the rapid detection of multiple pathogens and their antibiotic resistance genes in urinary tract infection.
The study developed a centrifugal disk system (LCD) for the rapid detection of multiple pathogens and their antibiotic resistance genes (ARGs) in urinary tract infections (UTIs). The LCD platform demonstrated high specificity and sensitivity for detecting pathogens and ARGs, including beta-lactamases (SHV, TEM, CTX-M-1 group, CTX-M-9 group), carbapenemases (KPC, NDM, IMP, OXA-23, OXA-24, OXA-48), ampC beta-lactamases (DHA, CMY), glycopeptide resistance (VanA), and methicillin resistance (mecA).
Co-Harboring of Beta-Lactamases and mcr-1 Genes in Escherichia coli and Klebsiella pneumoniae from Healthy Carriers and Backyard Animals in Rural Communities in Ecuador.
The study identified the co-harborance of beta-lactamase genes (bla TEM, bla SHV, bla CTX-M-9, bla CTX-M-1, bla OXA-48, bla NDM) and the mcr-1 gene in Escherichia coli and Klebsiella pneumoniae isolates from healthy humans and backyard animals in rural Ecuador. These findings highlight the potential threat to the efficacy of last-resort antibiotics.
In Vitro Activity of Cefiderocol against Clinical Gram-Negative Isolates Originating from Germany in 2016/17.
The study identified several beta-lactamase genes, including bla NDM-1, bla SHV-12, bla OXA-396, bla ACT-type, and bla CMH-3, which contribute to cefiderocol resistance in clinical Gram-negative isolates from Germany.
Source-tracking ESBL-producing bacteria at the maternity ward of Mulago hospital, Uganda.
The study identified bla CTX-M, bla TEM, bla SHV, bla VIM, bla IMP, and bla NDM genes as the primary drivers of extended-spectrum beta-lactamase (ESBL) and carbapenemase resistance in E. coli, K. pneumoniae, and Enterobacter spp. isolates from the maternity ward of Mulago Hospital, Uganda.
Resistance genomics and molecular epidemiology of high-risk clones of ESBL-producing Pseudomonas aeruginosa in young children.
The study identifies multiple AMR genes in ESBL-producing P. aeruginosa isolates from pediatric patients, including blaCTX-M-15, blaSHV-11, blaNDM-1, blaNDM-5, aac(3)IIIa, and tet(A). These genes contribute to resistance against cephalosporins, carbapenems, aminoglycosides, and glycylcyclines.
Isolation of Hv-CRKP with co-production of three carbapenemases (bla(KPC), bla(OXA-181) or (OXA-232), and bla(NDM-1)) and a virulence plasmid: a study from a Chinese tertiary hospital.
The study identifies the co-production of three carbapenemases (bla(KPC), bla(OXA-181) or (OXA-232), and bla(NDM-1)) in hypervirulent carbapenem-resistant Klebsiella pneumoniae (Hv-CRKP) isolates, highlighting the emergence of multidrug-resistant strains with hypervirulence traits.
Genomic analysis of extended-spectrum beta-lactamase (ESBL) producing Escherichia coli colonising adults in Blantyre, Malawi reveals previously undescribed diversity.
The study identifies various AMR genes in ESBL-producing E. coli isolates from Blantyre, Malawi, including bla CTX-M, bla SHV-12, and bla NDM-5, highlighting the diversity and resistance profiles of these isolates.
Evaluation of the synergistic effect of chitosan metal ions (Cu(2+)/Co(2+)) in combination with antibiotics to counteract the effects on antibiotic resistant bacteria.
The study identifies several antibiotic resistance genes, including mecA, blaz, pbp-4, pbp-1, blaTEM, blaCMY, and blaSHV, which are involved in resistance to penicillin in Staphylococcus aureus and Escherichia coli. These genes show reduced expression when treated with chitosan-metal ion nanoparticles in combination with antibiotics.
One Health compartment analysis of ESBL-producing Escherichia coli reveals multiple transmission events in a rural area of Madagascar.
The study identified blaCTX-M-15 as the most prevalent ESBL gene across all compartments, along with SHV-13, highlighting the genetic diversity and transmission dynamics of ESBL-producing E. coli in a rural area of Madagascar.
Fecal carriage of extended-spectrum beta-lactamase-producing Enterobacterales in healthy Spanish schoolchildren.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-14, bla CTX-M-15, bla SHV-12, bla CTX-M-27, bla CTX-M-32, and bla CTX-M-9, in ESBL-producing Enterobacterales isolated from healthy Spanish schoolchildren. These genes conferred resistance to various beta-lactam antibiotics.
Molecular Characterization and Prevalence of Antimicrobial-Resistant Escherichia coli Isolates Derived from Clinical Specimens and Environmental Habitats.
The study identified several AMR genes in E. coli isolates from clinical and environmental sources, including bla CTX-M-group 1, bla CTX-M-group 9, bla TEM, bla SHV, bla OXA-48, bla CMY-2, bla FOX, and sul1. These genes conferred resistance to various antibiotics such as beta-lactams, sulfamethoxazole-trimethoprim, and others.
Characterization of extended spectrum β-lactamase producing Escherichia coli strains isolated from urogenital system of dogs in Van province of Turkey.
The study identified bla TEM, bla SHV, and bla CTX-M group 1 genes in ESBL-producing E. coli isolates from dogs, highlighting the prevalence of extended-spectrum β-lactamase resistance.
Multi-Instrumental Analysis Toward Exploring the Diabetic Foot Infection Microbiota.
The study identified various beta-lactamase genes, including TEM, SHV, and CTX-M-9, in Gram-negative isolates from diabetic foot infections, highlighting the prevalence of extended-spectrum beta-lactamase (ESBL) production.
Multi-Instrumental Analysis Toward Exploring the Diabetic Foot Infection Microbiota.
The study identified various beta-lactamase genes, including TEM, SHV, and CTX-M-9, in Gram-negative isolates from diabetic foot infections, highlighting the prevalence of extended-spectrum beta-lactamase (ESBL) production.
Temporal dynamics of genetically heterogeneous extended-spectrum cephalosporin-resistant Escherichia coli bloodstream infections.
The study identifies bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, and bla CTX-M-14 as the dominant beta-lactamase genes conferring extended-spectrum cephalosporin resistance in E. coli bloodstream infections. Additional genes such as bla TEM-19, bla SHV-12, bla OXA-232, and bla NDM-5 were also characterized.
Impact of antimicrobial use on abundance of antimicrobial resistance genes in chicken flocks in Vietnam.
The study found that antimicrobial resistance genes (ARGs) such as mcr-1, arnA, blaCTX-M, blaSHV, erm, and mcr-3 were prevalent in chicken flocks in Vietnam, with variations in abundance across different production stages. The intervention reduced antimicrobial use but had inconsistent effects on ARGs depending on the measurement metric.
Detection of Extended-spectrum beta-lactamase-producing Escherichia coli isolates by isothermal amplification and association of their virulence genes and phylogroups with extraintestinal infection.
The study identified bla CTX-M, bla TEM, bla OXA, and bla SHV genes in ESBL-ExPEC isolates, with bla CTX-M being the most prevalent. The developed isothermal assays showed high sensitivity and specificity for detecting these genes.
The optimized carbapenem inactivation method for objective and accurate detection of carbapenemase-producing Acinetobacter baumannii.
The study identifies and characterizes several carbapenemase-encoding genes, including bla TEM, bla SHV, bla KPC, bla OXA-23-like, and bla OXA-51-like, in carbapenem-resistant Acinetobacter baumannii isolates.
Prevalence of AmpC, ESBL, and colistin resistance genes in Enterobacterales isolated from ready-to-eat food in Algeria.
The study identified the presence of various beta-lactamase genes (bla CTX-M, bla CMY-2, bla TEM, bla OXA-1, and bla SHV) and the mcr-1 gene in Enterobacterales isolated from ready-to-eat foods in Algeria. These genes confer resistance to multiple antibiotics, highlighting the potential public health concerns associated with antimicrobial resistance in food products.
Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.
The study identified various AMR genes in multidrug-resistant Gram-negative pathogens, highlighting the prevalence of bla CTX-M-15, bla CMY-42, bla NDM-5, aadA, bla TEM-1B, bla OXA-232, bla NDM-1, rmtB, rmtC, bla VEB, bla VIM-2, aph(3'), strA/B, bla OXA-23, aph (3′), catB, dfrB, bla VIM-2, fosA, oqxA, oqxB, bla OXA-23, bla CARB, bla OXA-91, bla OXA-51, bla PAO, bla SHV, aph (3′)-Ib, aph (6)-Id, mphE, msrE, ermB, mphA, aadA, rmtB, qnrB, dfrA, sul1, sul2, and fosA7.
Prevalence of multidrug-resistant and extensively drug-resistant phenotypes of Gram-negative bacilli isolated in clinical specimens at Centre Hospitalo-Universitaire Ibn Rochd, Morocco.
The study identified the presence of bla CTX-M, bla SHV, bla TEM, bla OXA-48, and bla NDM genes in Enterobacteriaceae isolates, contributing to multidrug resistance. bla CTX-M was the most prevalent, followed by bla OXA-48 and bla NDM.
Prevalence of multidrug-resistant and extended-spectrum beta-lactamase-producing Escherichia coli from chicken farms in Egypt.
The study found that 56% of chickens had E. coli infections, with 65.7% being ESBL producers. The bla TEM and bla SHV genes were detected in 60% and 35% of ESBL-producing E. coli isolates, respectively.
Molecular characterization and antibiotic resistance profile of ESBL-producing Escherichia coli isolated from healthy cow raw milk in smallholder dairy farms in Bangladesh.
The study identified ESBL-producing E. coli in raw milk from healthy cows in Bangladesh, with bla CTX-M-1, bla TEM, and bla SHV being the predominant genes. High resistance to various antibiotics was observed, highlighting the public health risk.
Genetic characterization of Escherichia coli and Klebsiella spp. from humans and poultry in Nigeria.
The study identified ESBL genes bla CTX-M-15 and bla SHV-28 in E. coli and Klebsiella spp. isolates from humans and poultry in Nigeria, highlighting the presence of multidrug-resistant bacteria with potential public health implications.
Antibiotic resistance and virulence genes profiling of Vibrio cholerae and Vibrio mimicus isolates from some seafood collected at the aquatic environment and wet markets in Eastern Cape Province, South Africa.
The study identified various antibiotic resistance genes and virulence genes in Vibrio cholerae and Vibrio mimicus isolates from seafood samples in South Africa, highlighting the presence of resistance to multiple antibiotics including polymyxin B, ampicillin, and fluoroquinolones.
Clinically Isolated β-Lactam-Resistant Gram-Negative Bacilli in a Philippine Tertiary Care Hospital Harbor Multi-Class beta-lactamase Genes.
The study identified multiple beta-lactamase genes in β-lactam-resistant Gram-negative bacilli from a Philippine hospital, highlighting the co-harbor of multi-class beta-lactamases and the presence of cryptic metallo-beta-lactamases in carbapenem-susceptible isolates.
Co-localization of clinically relevant antibiotic- and heavy metal resistance genes on plasmids in Klebsiella pneumoniae from marine bivalves.
The study identifies multiple antibiotic resistance genes (ARGs) and heavy metal resistance genes (HMRGs) co-localized on plasmids in Klebsiella pneumoniae isolated from marine bivalves, highlighting the potential for co-selection of these genes in the marine environment.
Clonal expansion and rapid characterization of Klebsiella pneumoniae ST1788, an otherwise uncommon strain spreading in Wales, UK.
The study identified several AMR genes in Klebsiella pneumoniae ST1788, including blaSHV-232, blaCTX-M-15, blaCTX-M-266, blaOXA-1, blaTEM-1, aac(3')-lla, aac(6')-lb-cr, strA, strB, qnrB1, dfrA14, sul2, and blaOXA-48. These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, trimethoprim, sulfamethoxazole, and carbapenems.
Clonal expansion and rapid characterization of Klebsiella pneumoniae ST1788, an otherwise uncommon strain spreading in Wales, UK.
Clonal expansion and rapid characterization of Klebsiella pneumoniae ST1788, an otherwise uncommon strain spreading in Wales, UK.
Impact of acquired broad-spectrum beta-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam beta-lactamase inhibitors in Escherichia coli.
The study evaluates the impact of various beta-lactamases on the susceptibility of Escherichia coli to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and their combinations with beta-lactamase inhibitors avibactam and taniborbactam.
Impact of acquired broad-spectrum beta-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam beta-lactamase inhibitors in Escherichia coli.
The study evaluates the impact of various beta-lactamases on the susceptibility of Escherichia coli to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and their combinations with beta-lactamase inhibitors avibactam and taniborbactam.
Impact of acquired broad-spectrum beta-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam beta-lactamase inhibitors in Escherichia coli.
The study evaluates the impact of various beta-lactamases on the susceptibility of Escherichia coli to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and their combinations with beta-lactamase inhibitors avibactam and taniborbactam.
Impact of acquired broad-spectrum beta-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam beta-lactamase inhibitors in Escherichia coli.
The study evaluates the impact of various beta-lactamases on the susceptibility of Escherichia coli to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and their combinations with beta-lactamase inhibitors avibactam and taniborbactam.
Phylogenetic lineages and antimicrobial resistance determinants of clinical Klebsiella oxytoca spanning local to global scales.
The study identified 10 variants of the intrinsic beta-lactamase gene blaOXY-2 in clinical Klebsiella oxytoca isolates, which confer resistance to penicillins. Additionally, two novel blaOXY-2 variants (blaOXY-2-35 and blaOXY-2-36) were discovered.
Genomic characterization of colistin-resistant Klebsiella pneumoniae isolated from intensive care unit patients in Egypt.
The study identifies mcr-1.1 as a plasmid-mediated colistin resistance gene and characterizes several chromosomal mutations in mgrB, arnT, pmrA, pmrB, pmrC, phoQ, and arnB that contribute to colistin resistance in K. pneumoniae isolates from Egypt.
Genomic characterization of colistin-resistant Klebsiella pneumoniae isolated from intensive care unit patients in Egypt.
The study identifies mcr-1.1 as a plasmid-mediated colistin resistance gene and characterizes several chromosomal mutations in mgrB, arnT, pmrA, pmrB, pmrC, phoQ, and arnB that contribute to colistin resistance in K. pneumoniae isolates from Egypt.
Genomic characterization of colistin-resistant Klebsiella pneumoniae isolated from intensive care unit patients in Egypt.
The study identifies mcr-1.1 as a plasmid-mediated colistin resistance gene and characterizes several chromosomal mutations in mgrB, arnT, pmrA, pmrB, pmrC, phoQ, and arnB that contribute to colistin resistance in K. pneumoniae isolates from Egypt.
Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding.
The study identifies beta-lactamases TEM-1, SHV-11, and NDM-1 as targets for aggregation-induced inactivation using synthetic peptides, demonstrating restored susceptibility to beta-lactam antibiotics in resistant clinical isolates.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Carbapenemase- and ESBL-Producing Gram-Negative Bacilli Isolated from Patients with Urinary Tract and Bloodstream Infections.
The study identified multiple carbapenemase and ESBL genes, including bla KPC-2, bla KPC-3, bla NDM, bla CTX-M-15, bla CTX-M-27, bla CTX-M-14, bla SHV-187, bla SHV-12, bla OXA-181, and others, highlighting the diversity of beta-lactam resistance mechanisms in Gram-negative bacteria from urinary tract and bloodstream infections.
Characterization of Carbapenemase- and ESBL-Producing Gram-Negative Bacilli Isolated from Patients with Urinary Tract and Bloodstream Infections.
The study identified multiple carbapenemase and ESBL genes, including bla KPC-2, bla KPC-3, bla NDM, bla CTX-M-15, bla CTX-M-27, bla CTX-M-14, bla SHV-187, bla SHV-12, bla OXA-181, and others, highlighting the diversity of beta-lactam resistance mechanisms in Gram-negative bacteria from urinary tract and bloodstream infections.
Extended Spectrum β-Lactamase-Producing Enterobacterales of Shrimp and Salmon Available for Purchase by Consumers in Canada-A Risk Profile Using the Codex Framework.
The study identifies several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV-12, bla SHV-2, and bla SHV-28, in ESBL-producing Enterobacterales isolated from retail shrimp and salmon in Canada. These genes confer resistance to third-generation cephalosporins.
Extended Spectrum β-Lactamase-Producing Enterobacterales of Shrimp and Salmon Available for Purchase by Consumers in Canada-A Risk Profile Using the Codex Framework.
The study identifies several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV-12, bla SHV-2, and bla SHV-28, in ESBL-producing Enterobacterales isolated from retail shrimp and salmon in Canada. These genes confer resistance to third-generation cephalosporins.
Extended Spectrum β-Lactamase-Producing Enterobacterales of Shrimp and Salmon Available for Purchase by Consumers in Canada-A Risk Profile Using the Codex Framework.
The study identifies several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV-12, bla SHV-2, and bla SHV-28, in ESBL-producing Enterobacterales isolated from retail shrimp and salmon in Canada. These genes confer resistance to third-generation cephalosporins.
Analyses of Extended-Spectrum-β-Lactamase, Metallo-β-Lactamase, and AmpC-β-Lactamase Producing Enterobacteriaceae from the Dairy Value Chain in India.
The study identified several β-lactamase genes, including bla CMY, bla MOX, bla FOX, bla EBC, bla DHA, bla CTX-M1, bla SHV, bla TEM, bla VIM, bla IMP, bla SPM, bla SIM, and bla GIM, in Enterobacteriaceae isolates from milk samples in India, highlighting the presence of multidrug-resistant bacteria in the dairy value chain.
Uropathogenic Escherichia coli (UPEC)-Associated Urinary Tract Infections: The Molecular Basis for Challenges to Effective Treatment.
This review discusses the molecular basis of challenges to effective treatment of UPEC-associated urinary tract infections, focusing on virulence factors and antibiotic resistance mechanisms.
Secondary Infection Surveillance with Metagenomic Next-Generation Sequencing in COVID-19 Patients: A Cross-Sectional Study.
The study identified several AMR genes, including blaKPC, blaSHV, blaCTX-M, blaTEM, blaOXA-23, blaOXA-51, blaNDM, mecA, and ErmB, which confer resistance to various antibiotics in clinically relevant pathogens.
In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales.
Xeruborbactam (XER) showed superior in vitro potency against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales when combined with various β-lactam antibiotics compared to other β-lactam/β-lactamase inhibitor combinations. XER effectively inhibited a wide range of β-lactamases, including metallo-β-lactamases (MBLs) and serine β-lactamases, enhancing the activity of antibiotics such as meropenem, cefepime, ceftolozane, ceftriaxone, aztreonam, piperacillin, and ertapenem.
Extensive Expression of the Virulome Related to Antibiotic Genotyping in Nosocomial Strains of Klebsiella pneumoniae.
The study identified several antibiotic resistance genes in multidrug-resistant Klebsiella pneumoniae strains, including beta-lactamases (bla TEM, bla SHV, bla CITM, bla CTXM-1), tetracycline resistance (tetA), sulfonamide resistance (sul1), aminoglycoside resistance (aac(3)-IV, aadA1), and others.
Prevalence and characterization of ESBL-producing Escherichia coli in healthy pregnant women and hospital environments in Benin: an approach based on Tricycle.
The study identified bla TEM, bla OXA-1, and bla SHV as the most prevalent ESBL-encoding genes in ESBL-producing E. coli isolates from healthy pregnant women and hospital effluents in Benin.
Colibacillosis in lambs and kids in Egypt: Prevalence, serogroups, antibiogram profile, virulence genes distribution and antimicrobial resistance genes.
The study identified blaSHV, blaCTX-M, and tetA as the primary antimicrobial resistance genes in E. coli isolates from diarrheic lambs and kids in Egypt, contributing to high resistance rates against several antibiotics.
Epidemiological study of antimicrobial-resistant bacteria in healthy free-ranging bantengs (Bos javanicus) and domestic cattle.
The study identified various ESBL genes, including CTX-M1, CTX-M9, SHV, CTX-M15, CTX-M55, CTX-M14, and CTX-M79, in CTX-resistant E. coli isolates from bantengs and domestic cattle, highlighting the presence of antimicrobial resistance in wild populations.
Characterization of extended spectrum beta-lactamases in Colombian clinical isolates of non-typhoidal Salmonella enterica between 1997 and 2022.
The study identified the prevalence of extended-spectrum beta-lactamases (ESBLs) in Salmonella enterica isolates in Colombia, primarily mediated by bla CTX-M, bla TEM, and bla SHV genes, leading to resistance against third- and fourth-generation cephalosporins.
Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae
The study identifies a novel mechanism of ceftazidime/avibactam resistance in Klebsiella pneumoniae due to overexpression of blaSHV-12 caused by an additional promoter, highlighting a new evolutionary pathway for resistance development.
Genome analysis of third-generation cephalosporin-resistant Escherichia coli and Salmonella species recovered from healthy and diseased food-producing animals in Europe.
The study identified various beta-lactamase genes (bla CTX-M-1, bla CTX-M-15, bla CMY-2, bla SHV-12, bla CTX-M-14, bla CTX-M-55) and polymyxin resistance genes (mcr-1, mcr-3, mcr-4) in third-generation cephalosporin-resistant Escherichia coli and Salmonella species from food-producing animals in Europe.
Comparative Genomic Analysis Reveals the Emergence of ST-231 and ST-395 Klebsiella pneumoniae Strains Associated with the High Transmissibility of bla(KPC) Plasmids.
The study identifies multiple AMR genes, including blaOXA-232, blaCTX-M-15, dfrA14, aac(6')-Ib-cr, and others, in K. pneumoniae isolates, highlighting the role of integrons and plasmids in the dissemination of resistance.
Comparative Genomic Analysis Reveals the Emergence of ST-231 and ST-395 Klebsiella pneumoniae Strains Associated with the High Transmissibility of bla(KPC) Plasmids.
The study identifies multiple AMR genes, including blaOXA-232, blaCTX-M-15, dfrA14, aac(6')-Ib-cr, and others, in K. pneumoniae isolates, highlighting the role of integrons and plasmids in the dissemination of resistance.
Comparative Genomic Analysis Reveals the Emergence of ST-231 and ST-395 Klebsiella pneumoniae Strains Associated with the High Transmissibility of bla(KPC) Plasmids.
The study identifies multiple AMR genes, including blaOXA-232, blaCTX-M-15, dfrA14, aac(6')-Ib-cr, and others, in K. pneumoniae isolates, highlighting the role of integrons and plasmids in the dissemination of resistance.
Comparative Genomic Analysis Reveals the Emergence of ST-231 and ST-395 Klebsiella pneumoniae Strains Associated with the High Transmissibility of bla(KPC) Plasmids.
The study identifies multiple AMR genes, including blaOXA-232, blaCTX-M-15, dfrA14, aac(6')-Ib-cr, and others, in K. pneumoniae isolates, highlighting the role of integrons and plasmids in the dissemination of resistance.
Unveiling the genome of a high-risk pandrug-resistant Klebsiella pneumoniae emerging in the Brazilian Amazon Region, 2022.
The study identified a pandrug-resistant Klebsiella pneumoniae strain (Kp196) with a complex resistome comprising numerous acquired and intrinsic resistance mechanisms, including multiple beta-lactamases, aminoglycoside-modifying enzymes, quinolone resistance proteins, and mutations in genes involved in colistin, tigecycline, and fluoroquinolone resistance.
Evaluation of antibiotic resistance, toxin-antitoxin systems, virulence factors, biofilm-forming strength and genetic linkage of Escherichia coli strains isolated from bloodstream infections of leukemia patients.
The study identified bla CTX-M, bla TEM, bla SHV, bla OXA-48, qnr B, and qnr S genes as the main contributors to antibiotic resistance in E. coli strains isolated from bloodstream infections of leukemia patients.
Gut acquisition of Extended-spectrum beta-lactamases-producing Klebsiella pneumoniae in preterm neonates: Critical role of enteral feeding, and endotracheal tubes in the neonatal intensive care unit (NICU).
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including blaSHV, blaTEM, blaCTX-M-1, blaCTX-M-2, blaCTX-M-9, and blaOXA-48, in Klebsiella pneumoniae isolates from preterm neonates. These genes were associated with resistance to multiple antibiotics, including amoxicillin, clavulanic acid-amoxicillin, cefotaxime, ceftazidime, and gentamicin. The study also found that enteral tube feeding and endotracheal tubes were significant risk factors for ESBL-KP colonization in the NICU.
The notable relatedness between ESBL producing Enterobacteriaceae isolated from clinical samples and asymptomatic fecal carriers.
The study identified the presence of ESBL genes bla CTX, bla SHV, and bla TEM in both clinical and fecal carrier isolates of Klebsiella pneumoniae and Escherichia coli, highlighting their role in resistance to beta-lactam antibiotics.
Characterization of integrons, extended spectrum beta lactamases and genetic diversity among uropathogenic Escherichia coli isolates from Kerman, south east of Iran.
The study identified the presence of class I integrons and ESBLs, particularly bla CTX-M, bla TEM, and bla SHV, in uropathogenic E. coli isolates from Kerman, Iran. Additionally, various gene cassettes such as dfrA17-aadA5, aadA1-dfrA1, and others were detected, contributing to resistance against multiple antibiotics.
Persistent effects of intramammary ceftiofur treatment on the gut microbiome and antibiotic resistance in dairy cattle.
The study identified the persistence of extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M, blaCMY, and blaCfxA, in the gut microbiome of dairy cattle following intramammary ceftiofur treatment. These genes were associated with increased resistance to ceftiofur and were observed to persist for up to 9 weeks post-treatment.
Distribution of ß-Lactamase Genes Among Multidrug-Resistant and Extended-Spectrum ß-Lactamase-Producing Diarrheagenic Escherichia coli from Under-Five Children in Ethiopia.
The study identified the presence of bla TEM, bla CTX-M, bla SHV, bla NDM, and bla OXA-48 genes in multidrug-resistant and extended-spectrum beta-lactamase-producing diarrheagenic Escherichia coli isolates from under-five children in Ethiopia, highlighting the emergence of these resistance genes in the region.
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
Genomic analysis reveals the presence of emerging pathogenic Klebsiella lineages aboard the International Space Station.
The study identifies antimicrobial resistance genes such as blaSHV-1, blaOKP-B-8, and blaOKP-B-3 in Klebsiella isolates from the International Space Station, highlighting their resistance to various antibiotics.
Molecular Epidemiology of Carbapenem Resistant Klebsiella Pneumoniae in Northern China: Clinical Characteristics, Antimicrobial Resistance, Virulence and Geographic Distribution.
The study identified several carbapenemase genes, including bla NDM-1, bla NDM-5, bla KPC-2, bla OXA-23, bla SME, and bla IMI, as well as extended-spectrum beta-lactamase genes such as bla CTX-M, bla SHV, and bla TEM, and AmpC beta-lactamase gene bla DHA, which contribute to carbapenem resistance in CRKP isolates from Shanxi Province.
Enterobacteriaceae isolates from clinical and household tap water samples: antibiotic resistance, screening for extended-spectrum, metallo- and ampC-beta-lactamases, and detection of bla(TEM,)bla(SHV) and bla(CTX-M) in Uyo, Nigeria.
The study identified the presence of blaTEM, blaSHV, and blaCTX-M genes in Enterobacteriaceae isolates from clinical and tap water samples in Uyo, Nigeria, highlighting the prevalence of extended-spectrum beta-lactamase (ESBL) producers and their association with multidrug resistance.
Transmission of β-lactamases in the pork food chain: A public health concern.
The study identified the presence of β-lactamase genes, including bla CTX-M1, bla CTX-M2, bla TEM, and bla SHV, in Escherichia coli isolates from the pork food chain, indicating the potential transmission of β-lactam resistance from farm to fork.
Molecular epidemiology and pathogenomics of extended-spectrum beta-lactamase producing- Escherichia coli and - Klebsiella pneumoniae isolates from bulk tank milk in Tennessee, USA.
The study identified multiple AMR genes and mutations in ESBL-producing E. coli and K. pneumoniae isolates from bulk tank milk, highlighting the presence of multidrug-resistant strains with resistance to beta-lactams, fluoroquinolones, aminoglycosides, and tetracyclines.
Molecular epidemiology and pathogenomics of extended-spectrum beta-lactamase producing- Escherichia coli and - Klebsiella pneumoniae isolates from bulk tank milk in Tennessee, USA.
The study identified multiple AMR genes and mutations in ESBL-producing E. coli and K. pneumoniae isolates from bulk tank milk, highlighting the presence of multidrug-resistant strains with resistance to beta-lactams, fluoroquinolones, aminoglycosides, and tetracyclines.
Molecular epidemiology and pathogenomics of extended-spectrum beta-lactamase producing- Escherichia coli and - Klebsiella pneumoniae isolates from bulk tank milk in Tennessee, USA.
The study identified multiple AMR genes and mutations in ESBL-producing E. coli and K. pneumoniae isolates from bulk tank milk, highlighting the presence of multidrug-resistant strains with resistance to beta-lactams, fluoroquinolones, aminoglycosides, and tetracyclines.
Genetic characterization of a multidrug-resistant Salmonella enterica serovar Agona isolated from a dietary supplement in Germany.
The study identifies 23 antibiotic resistance genes (ARGs) in a multidrug-resistant Salmonella enterica serovar Agona isolate from a dietary supplement in Germany, conferring resistance to 12 different antibiotic classes. Key genes include blaSHV-12, aac(3)-Iig, aac(6')-Iic, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, dfrA19, qacEΔ1, ere(A), sul1, sul2, tet(D), mcr-9.1, catA2, arr, qnrS1, blaTEM-1, aac(3)-IIe, and floR.
Fecal carriage of extended-spectrum beta-lactamase-producing enterobacterales from hospitals and community settings in Gaza Strip, Palestine.
The study identified bla CTX-M, bla TEM, and bla SHV genes as the main contributors to extended-spectrum beta-lactamase (ESBL) production in Enterobacterales in Gaza Strip, with bla CTX-M being the most prevalent.
Characterization of beta-lactamase producing Enterobacterales isolated from an urban community wastewater treatment plant in Iran.
The study identified various beta-lactamase genes, including bla CTX-M, bla TEM, bla SHV, bla DHA, bla CIT, and bla FOX, in Enterobacterales isolates from a wastewater treatment plant in Iran, highlighting the presence of multidrug-resistant strains.
Comparison of the inoculum effect of in vitro antibacterial activity of Imipenem/relebactam and Ceftazidime/avibactam against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae.
The study evaluated the inoculum effect of Imipenem/relebactam (IMR) and Ceftazidime/avibactam (CZA) against ESBL-, KPC-, and AmpC-producing E. coli and K. pneumoniae. It identified several beta-lactamase genes, including bla TEM-1, bla AmpC, bla CTX-M-14, bla OXA-10, bla CTX-M-55, bla CMY-42, bla CTX-M-15, bla KPC-2, bla OXA-9, bla SHV-182, bla SHV-18, bla OXA-2, bla OKP-B-7, bla DHA-1, bla SHV-27, bla CTX-M-65, bla SHV-11, bla SHV-145, bla SHV-12, bla SHV-106, bla SHV-110, bla SHV106, and bla CTX-M-14, which confer resistance to ceftazidime and/or imipenem.
Comparison of the inoculum effect of in vitro antibacterial activity of Imipenem/relebactam and Ceftazidime/avibactam against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae.
The study evaluated the inoculum effect of Imipenem/relebactam (IMR) and Ceftazidime/avibactam (CZA) against ESBL-, KPC-, and AmpC-producing E. coli and K. pneumoniae. It identified several beta-lactamase genes, including bla TEM-1, bla AmpC, bla CTX-M-14, bla OXA-10, bla CTX-M-55, bla CMY-42, bla CTX-M-15, bla KPC-2, bla OXA-9, bla SHV-182, bla SHV-18, bla OXA-2, bla OKP-B-7, bla DHA-1, bla SHV-27, bla CTX-M-65, bla SHV-11, bla SHV-145, bla SHV-12, bla SHV-106, bla SHV-110, bla SHV106, and bla CTX-M-14, which confer resistance to ceftazidime and/or imipenem.
Comparison of the inoculum effect of in vitro antibacterial activity of Imipenem/relebactam and Ceftazidime/avibactam against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae.
The study evaluated the inoculum effect of Imipenem/relebactam (IMR) and Ceftazidime/avibactam (CZA) against ESBL-, KPC-, and AmpC-producing E. coli and K. pneumoniae. It identified several beta-lactamase genes, including bla TEM-1, bla AmpC, bla CTX-M-14, bla OXA-10, bla CTX-M-55, bla CMY-42, bla CTX-M-15, bla KPC-2, bla OXA-9, bla SHV-182, bla SHV-18, bla OXA-2, bla OKP-B-7, bla DHA-1, bla SHV-27, bla CTX-M-65, bla SHV-11, bla SHV-145, bla SHV-12, bla SHV-106, bla SHV-110, bla SHV106, and bla CTX-M-14, which confer resistance to ceftazidime and/or imipenem.
Comparison of the inoculum effect of in vitro antibacterial activity of Imipenem/relebactam and Ceftazidime/avibactam against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae.
The study evaluated the inoculum effect of Imipenem/relebactam (IMR) and Ceftazidime/avibactam (CZA) against ESBL-, KPC-, and AmpC-producing E. coli and K. pneumoniae. It identified several beta-lactamase genes, including bla TEM-1, bla AmpC, bla CTX-M-14, bla OXA-10, bla CTX-M-55, bla CMY-42, bla CTX-M-15, bla KPC-2, bla OXA-9, bla SHV-182, bla SHV-18, bla OXA-2, bla OKP-B-7, bla DHA-1, bla SHV-27, bla CTX-M-65, bla SHV-11, bla SHV-145, bla SHV-12, bla SHV-106, bla SHV-110, bla SHV106, and bla CTX-M-14, which confer resistance to ceftazidime and/or imipenem.
Comparison of the inoculum effect of in vitro antibacterial activity of Imipenem/relebactam and Ceftazidime/avibactam against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae.
The study evaluated the inoculum effect of Imipenem/relebactam (IMR) and Ceftazidime/avibactam (CZA) against ESBL-, KPC-, and AmpC-producing E. coli and K. pneumoniae. It identified several beta-lactamase genes, including bla TEM-1, bla AmpC, bla CTX-M-14, bla OXA-10, bla CTX-M-55, bla CMY-42, bla CTX-M-15, bla KPC-2, bla OXA-9, bla SHV-182, bla SHV-18, bla OXA-2, bla OKP-B-7, bla DHA-1, bla SHV-27, bla CTX-M-65, bla SHV-11, bla SHV-145, bla SHV-12, bla SHV-106, bla SHV-110, bla SHV106, and bla CTX-M-14, which confer resistance to ceftazidime and/or imipenem.
Comparison of the inoculum effect of in vitro antibacterial activity of Imipenem/relebactam and Ceftazidime/avibactam against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae.
The study evaluated the inoculum effect of Imipenem/relebactam (IMR) and Ceftazidime/avibactam (CZA) against ESBL-, KPC-, and AmpC-producing E. coli and K. pneumoniae. It identified several beta-lactamase genes, including bla TEM-1, bla AmpC, bla CTX-M-14, bla OXA-10, bla CTX-M-55, bla CMY-42, bla CTX-M-15, bla KPC-2, bla OXA-9, bla SHV-182, bla SHV-18, bla OXA-2, bla OKP-B-7, bla DHA-1, bla SHV-27, bla CTX-M-65, bla SHV-11, bla SHV-145, bla SHV-12, bla SHV-106, bla SHV-110, bla SHV106, and bla CTX-M-14, which confer resistance to ceftazidime and/or imipenem.
Comparison of the inoculum effect of in vitro antibacterial activity of Imipenem/relebactam and Ceftazidime/avibactam against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae.
The study evaluated the inoculum effect of Imipenem/relebactam (IMR) and Ceftazidime/avibactam (CZA) against ESBL-, KPC-, and AmpC-producing E. coli and K. pneumoniae. It identified several beta-lactamase genes, including bla TEM-1, bla AmpC, bla CTX-M-14, bla OXA-10, bla CTX-M-55, bla CMY-42, bla CTX-M-15, bla KPC-2, bla OXA-9, bla SHV-182, bla SHV-18, bla OXA-2, bla OKP-B-7, bla DHA-1, bla SHV-27, bla CTX-M-65, bla SHV-11, bla SHV-145, bla SHV-12, bla SHV-106, bla SHV-110, bla SHV106, and bla CTX-M-14, which confer resistance to ceftazidime and/or imipenem.
Comparison of the inoculum effect of in vitro antibacterial activity of Imipenem/relebactam and Ceftazidime/avibactam against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae.
The study evaluated the inoculum effect of Imipenem/relebactam (IMR) and Ceftazidime/avibactam (CZA) against ESBL-, KPC-, and AmpC-producing E. coli and K. pneumoniae. It identified several beta-lactamase genes, including bla TEM-1, bla AmpC, bla CTX-M-14, bla OXA-10, bla CTX-M-55, bla CMY-42, bla CTX-M-15, bla KPC-2, bla OXA-9, bla SHV-182, bla SHV-18, bla OXA-2, bla OKP-B-7, bla DHA-1, bla SHV-27, bla CTX-M-65, bla SHV-11, bla SHV-145, bla SHV-12, bla SHV-106, bla SHV-110, bla SHV106, and bla CTX-M-14, which confer resistance to ceftazidime and/or imipenem.
The secrets of environmental Pseudomonas aeruginosa in slaughterhouses: Antibiogram profile, virulence, and antibiotic resistance genes.
The study identified multiple antibiotic resistance genes in Pseudomonas aeruginosa isolates from slaughterhouses, including blaCTX-M, blaAmpC, blaSHV, blaNDM, IMP-1, aac(6')-Ib, ant(4')IIb, qnrB, tetA, mexY, TEM, and rmtC. These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, and tetracyclines.
Antimicrobial Resistance Profiles of Multidrug-Resistant Enterobacteria Isolated from Feces of Weaned Piglets.
The study identified the presence of various AMR genes, including bla TEM, bla SHV, bla CTX-M, tetA, and mcr-1, in multidrug-resistant enterobacteria isolated from weaned piglets. These genes were associated with resistance to beta-lactams, tetracycline, and colistin.
Evolution of extended-spectrum beta-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years.
The study identifies various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-15, blaCTX-M-27, blaCTX-M-14, and others, in ST131 Escherichia coli isolates from a single hospital over 15 years. These genes are responsible for resistance to multiple β-lactam antibiotics and are carried on both plasmids and the chromosome. Mutations in genes such as ftsI, arnC, gloB, and fyuA were also found to contribute to resistance mechanisms.
Evolution of extended-spectrum beta-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years.
The study identifies various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-15, blaCTX-M-27, blaCTX-M-14, and others, in ST131 Escherichia coli isolates from a single hospital over 15 years. These genes are responsible for resistance to multiple β-lactam antibiotics and are carried on both plasmids and the chromosome. Mutations in genes such as ftsI, arnC, gloB, and fyuA were also found to contribute to resistance mechanisms.
Metagenomic assembly is the main bottleneck in the identification of mobile genetic elements.
The study evaluated the performance of tools for identifying mobile genetic elements (MGEs) and antimicrobial resistance genes (ARGs) in metagenomic data. It found that metagenomic assembly is the main bottleneck in accurately identifying MGEs and ARGs, with moderate precision and sensitivity for plasmids, phages, IS elements, and ARGs.
Genome sequencing unveils bla(KPC-2)-harboring plasmids as drivers of enhanced resistance and virulence in nosocomial Klebsiella pneumoniae.
The study identifies blaKPC-2, blaSHV-12, and blaCTX-M-65 as key genes contributing to carbapenem and ceftazidime/avibactam resistance in nosocomial Klebsiella pneumoniae, highlighting the role of plasmid-mediated resistance and gene amplification in clinical settings.
Genotypic characterization of extended spectrum beta-lactamase in gram negative bacterial contaminants of some door handles in Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun state.
The study identified blaTEM, blaCTX-M, and blaSHV genes in Gram-negative bacterial isolates from door handles, indicating the presence of extended-spectrum beta-lactamase (ESBL) producing bacteria in the hospital environment.
Occurrence and characteristics of extended-spectrum-β-lactamase- and pAmpC-producing Klebsiella pneumoniae isolated from companion animals with urinary tract infections.
The study identified several extended-spectrum beta-lactamase (ESBL) and plasmid-encoded AmpC (pAmpC) genes in Klebsiella pneumoniae isolates from companion animals with urinary tract infections, highlighting the prevalence of these resistance mechanisms.
Prevalence and antimicrobial resistance profiles of extended-spectrum beta-lactamase-producing Escherichia coli in East Tennessee dairy farms.
The study identified extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in East Tennessee dairy farms, with high prevalence and multidrug resistance. Key AMR genes included blaCTX-M, blaSHV, and blaTEM, which conferred resistance to beta-lactam antibiotics such as ampicillin and ceftriaxone.
Rapid and visual identification of beta-lactamase subtypes for precision antibiotic therapy.
The study presents a paper-based sensor (BSV sensor) capable of rapidly and visually identifying beta-lactamase subtypes, including BSBL, ESBL, AmpC, and carbapenemases, enabling precise antibiotic therapy.
Genomic investigation unveils high-risk ESBL producing Enterobacteriaceae within a rural environmental water body.
The study identifies several AMR genes and mutations in ESBL-producing Enterobacteriaceae isolated from a rural environmental water body in India, highlighting the presence of multidrug-resistant strains with genes such as bla VEB-6, bla SHV-12, bla NDM-1, bla CTX-M, and mcr-9, along with mutations in ompK 36 and gyrA.
Multiplex Microarrays in 96-Well Plates Photoactivated with 4-Azidotetrafluorobenzaldehyde for the Identification and Quantification of beta-lactamase Genes and Their RNA Transcripts.
The study developed a novel microarray technique using photoactivated 96-well plates to identify and quantify beta-lactamase genes and their RNA transcripts. The method successfully detected various beta-lactamase genes, including ESBLs, inhibitor-resistant beta-lactamases, and carbapenemases, demonstrating high specificity and reproducibility.
Dissemination of mcr-1 and β-lactamase genes among Pseudomonas aeruginosa: molecular characterization of MDR strains in broiler chicks and dead-in-shell chicks infections.
The study identified the presence of mcr-1 and various β-lactamase genes, including bla TEM, bla SHV, bla CTX-M, and bla OXA-10, in multidrug-resistant Pseudomonas aeruginosa isolates from broiler and dead-in-shell chicks in Egypt.
Gut colonization and subsequent infection of neonates caused by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae.
The study identified the prevalence of ESBL-PEco and ESBL-PKpn in neonatal patients, with bla CTX-M-1 group, bla TEM, bla OXA-1, and bla SHV being the most common genes. These genes conferred resistance to various cephalosporins.
Klebsiella pneumoniae ST147 harboring bla(NDM-1), multidrug resistance and hypervirulence plasmids.
The study identifies the blaNDM-1 gene and various other resistance genes in multidrug-resistant Klebsiella pneumoniae ST147 strains, highlighting their role in carbapenem resistance and hypervirulence.
Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing.
The paper discusses the prevalence of antimicrobial resistance in Aeromonas species, highlighting the presence of various beta-lactamase genes such as blaTEM-24, blaIMP-19, blaVIM-4, blaKPC-2, blaNDM-1, blaVIM-2, blaOXA-48, blaIMP-13, blaGES-5, blaTEM-1, blaSHV-12, blaVEB-9, blaMOX, blaFOX, blaACC, and others. It also identifies genes like cphA, vat, mcr-3.41, mcr-7.1, sul, dfr, tetA, rsmA, and adeF associated with resistance to sulfonamides, trimethoprim, tetracycline, polymyxin, and other antibiotics. The study emphasizes the role of horizontal gene transfer and mobile genetic elements in the dissemination of these resistance genes.
Outbreak of Multidrug-resistant Acinetobacter baumannii in a Tertiary Health Center from Northwestern Nigeria.
MDR strains of A. baumannii harboring bla SHV and bla TEM genes were recovered from clinical and environmental sources during the outbreak.
Phage vB_Ec_ZCEC14 to treat antibiotic-resistant Escherichia coli isolated from urinary tract infections.
The study identifies several antibiotic resistance genes in multidrug-resistant E. coli isolates, including blaTEM, blaSHV, blaCTX, and tetA, which confer resistance to amoxicillin, ceftriaxone, and tetracycline. These findings highlight the genetic basis of resistance in the isolates.
Emergence of multidrug-resistant Bacillus spp. derived from animal feed, food and human diarrhea in South-Eastern Bangladesh.
The study identifies multiple AMR genes in Bacillus spp. isolated from animal feed, food, and human diarrhea in Bangladesh, highlighting the prevalence of multidrug resistance and the need for monitoring in the agricultural and food sectors.
CTX-M, TEM, and SHV Genes in Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp Isolated from Hematologic Cancer Patients with Bacteremia in Uganda.
The study identified bla CTX-M, bla TEM, and bla SHV as the most prevalent ESBL-encoding genes in Enterobacteriaceae causing bacteremia in hematologic cancer patients in Uganda. bla CTX-M was the most common, followed by bla TEM and then bla SHV.
Comparison of the Antibiotic Resistance of Escherichia coli Populations from Water and Biofilm in River Environments.
The study identified several beta-lactamase genes, including bla CTX-M-15, bla CTX-M-1, bla CTX-M-14, bla SHV-12, bla TEM-1, and bla KPC-2, which confer resistance to various antibiotics in E. coli isolates from river environments.
Correlation between antimicrobial resistance, biofilm formation, and virulence determinants in uropathogenic Escherichia coli from Egyptian hospital.
The study identified bla TEM, bla SHV, and bla CTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) production in UPEC isolates from Tanta, Egypt. These genes were associated with resistance to multiple antibiotics, including cephalosporins and penicillins.
Characterization of resistance genes and replicon typing in Carbapenem-resistant Klebsiella pneumoniae strains.
The study identified several beta-lactamase genes, including bla OXA-48, bla SHV, bla TEM, bla CTX-M1, bla CTX-M2, bla IMP, and bla NDM, which contribute to carbapenem resistance in Klebsiella pneumoniae strains. The most prevalent gene was bla OXA-48, found in 96.6% of isolates.
Genomic insights and antimicrobial resistance profiles of CRKP and non-CRKP isolates in a Beijing geriatric medical center: emphasizing the bla(KPC-2) carrying high-risk clones and their spread.
The study identifies blaKPC-2 as a key gene in carbapenem resistance among CRKP isolates, along with other resistance genes such as rmtB, APH(3')-Ia, and QnrB4. It also highlights the prevalence of ST11-KL47-OL101 clones and the role of plasmid pKpnR03_2 in the spread of resistance.
Genomic insights and antimicrobial resistance profiles of CRKP and non-CRKP isolates in a Beijing geriatric medical center: emphasizing the bla(KPC-2) carrying high-risk clones and their spread.
The study identifies blaKPC-2 as a key gene in carbapenem resistance among CRKP isolates, along with other resistance genes such as rmtB, APH(3')-Ia, and QnrB4. It also highlights the prevalence of ST11-KL47-OL101 clones and the role of plasmid pKpnR03_2 in the spread of resistance.
Antimicrobial Resistance in Salmonella spp. from Food-Producing Animals and Human Cases in the EU
The study identifies several AMR genes, including bla CTX-M-1, bla CTX-M-14b, bla SHV-12, tet(X3), and tet(X4), in Salmonella isolates from food-producing animals and human cases in the EU. These genes confer resistance to various antibiotics, highlighting the spread of multidrug-resistant Salmonella strains.
Antibiotic resistance and virulence genes profile of Non typhodial Salmonella species isolated from poultry enteritis in India.
The study identified several antibiotic resistance genes including blaTEM, blaSHV, blaCTX-M, tet(A), tet(B), tet(C), sul1, sul2, and sul3 in multidrug-resistant Salmonella isolates from poultry enteritis in India.
Antibiogram and molecular characterization of extended-spectrum β-lactamase-producing pathogens implicated in chronic suppurative otitis media.
The study identified blaSHV, blaTEM, and blaCTX-M as the most prevalent ESBL genes in ESBL-producing GNB pathogens isolated from CSOM patients, highlighting the emergence of multidrug-resistant strains.
Gut diversity and the resistome as biomarkers of febrile neutropenia outcome in paediatric oncology patients undergoing hematopoietic stem cell transplantation.
The study identifies several antibiotic-resistance genes associated with febrile neutropenia in pediatric oncology patients undergoing hematopoietic stem cell transplantation, including msr(C), dfrG, erm(T), VanHAX, aac(6')-Ib, aph(3')-III, ant(6)-Ia, and aac(6')-Ii.
Phenotypic, molecular detection, and Antibiotic Resistance Profile (MDR and XDR) of Aeromonas hydrophila isolated from Farmed Tilapia zillii and Mugil cephalus.
The study identified several AMR genes in Aeromonas hydrophila isolates from farmed fish, including bla_pse1, bla_SHV, tetA, and sul1, which confer resistance to beta-lactams, tetracyclines, and sulfonamides.
Uncovering the spread of drug-resistant bacteria through next-generation sequencing based surveillance: transmission of extended-spectrum beta-lactamase-producing Enterobacterales by a contaminated duodenoscope.
The study identifies bla CTX-M-15 in Citrobacter freundii and bla SHV-12 in Klebsiella pneumoniae as the resistance mechanisms responsible for the transmission of multidrug-resistant organisms through a contaminated duodenoscope.
Plasmid-encoded gene duplications of extended-spectrum beta-lactamases in clinical bacterial isolates.
The study identifies plasmid-encoded gene duplications of extended-spectrum beta-lactamases (ESBLs) in clinical bacterial isolates, demonstrating that these duplications lead to increased resistance to ceftazidime.
Plasmid-encoded gene duplications of extended-spectrum beta-lactamases in clinical bacterial isolates.
The study identifies plasmid-encoded gene duplications of extended-spectrum beta-lactamases (ESBLs) in clinical bacterial isolates, demonstrating that these duplications lead to increased resistance to ceftazidime.
Activity of Epsilon-poly-L-lysine against Multidrug-Resistant Pseudomonas aeruginosa and Klebsiella pneumoniae Isolates of Urinary Tract Infections.
The study identified various beta-lactamase genes, including blaSPM, blaKPC, blaSHV, blaCTX-M, blaOXA, blaTEM, blaPER, blaVIM, and blaVIM-2 in Pseudomonas aeruginosa, and blaCTX-M, blaTEM, blaKPC, blaNDM, and blaOXA in Klebsiella pneumoniae. Additionally, aac(3)-IV, aadA1, aac(3)-II, sul2, sul1, sul3, dfrA, cmlA, and tetA were found to confer resistance to aminoglycosides, sulfonamides, trimethoprim, chloramphenicol, and tetracyclines.
Extended-spectrum beta-lactamases in clinical isolates of Escherichia coli and Klebsiella pneumoniae recovered from patients at the Tamale Teaching Hospital, Ghana.
The study identified bla TEM, bla CTX-M-1, and bla SHV genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) resistance in E. coli and K. pneumoniae isolates from the Tamale Teaching Hospital in Ghana.
Klebsiella pneumoniae exhibiting a phenotypic hyper-splitting phenomenon including the formation of small colony variants.
The study identifies multiple beta-lactamase genes, including bla SHV-11, bla OXA-1, bla OXA-9, bla OXA-48, bla TEM-1D, bla CTX-M-15, and bla NDM-1, as well as sul1 and catB3, which confer resistance to various antibiotics in Klebsiella pneumoniae isolates from a patient with a complex infection history.
Rapid detection and molecular epidemiology of beta-lactamase producing Enterobacteriaceae isolated from food animals and in-contact humans in Nigeria.
The study developed and validated a multiplex qPCR assay for detecting beta-lactamase genes (bla CTX-M, bla TEM, and bla SHV) in Enterobacteriaceae isolated from food animals and in-contact humans in Nigeria. The assay showed 100% sensitivity and specificity. The prevalence of bla TEM and bla SHV varied among different species and sampling locations, with Klebsiella pneumoniae showing the highest prevalence of these genes.
Detection of Extended Spectrum ß-Lactamase-Producing Escherichia coli with Biofilm Formation from Chicken Meat in Istanbul.
The study identified bla TEM, bla CTX-M, bla SHV, and bla OXA genes in E. coli isolates from chicken meat in Istanbul, with bla TEM being the most prevalent. No mcr, bla NDM, bla KPC, bla VIM, or bla OXA-48 genes were detected.
Identification and Evaluation of Pathogenic Genes (traT, hly, aer, pap, and fimH) and Antibiotic Resistance Genes (blaTEM, blaSHV, and blaCTX) in Escherichia coli in Patients Referred to Gonabad Hospitals, Iran.
The study identified blaTEM, blaSHV, and blaCTX genes as prevalent beta-lactam resistance genes in E. coli isolates from UTI patients in Gonabad, Iran, contributing to multidrug resistance.
Phenotypic and genotypic characterization of extended spectrum beta-lactamase producing E. coli harboring carbapenem and colistin-resistant genes from poultry farms in Egypt.
The study identified multiple AMR genes in ESBL-producing E. coli from poultry farms in Egypt, including bla TEM-3, bla SHV-4, bla CTX-M-1, bla CTX-M-14, bla NDM-1, and mcr-1, highlighting the public health risks associated with multidrug-resistant E. coli.
What Contributes to the Minimum Inhibitory Concentration? Beyond beta-lactamase Gene Detection in Klebsiella pneumoniae.
The study highlights the complex interplay between beta-lactamases and outer membrane porins in determining β-lactam resistance in Klebsiella pneumoniae. Plasmid-encoded beta-lactamases such as CTX-M-14, CTX-M-15, CMY-2, and DHA-1, as well as chromosomal SHV-5, were found to confer resistance to various β-lactam antibiotics. Additionally, loss of outer membrane porins OmpK35, OmpK36, and PhoE was associated with meropenem resistance.
High prevalence of multidrug-resistant Enterobacterales carrying extended-spectrum beta-lactamase and AmpC genes isolated from neonatal sepsis in Ahvaz, Iran.
The study identified a high prevalence of multidrug-resistant Enterobacterales carrying extended-spectrum beta-lactamase (ESBL) and AmpC genes, with bla CTX-M−15 being the most common ESBL gene.
Resistome Analysis of Klebsiella pneumoniae Complex from Residential Aged Care Facilities Demonstrates Intra-facility Clonal Spread of Multidrug-Resistant Isolates.
The study identified several AMR genes and mutations in K. pneumoniae isolates from RACFs, including beta-lactamases (bla DHA-1, bla SHV-1, bla SHV-27, bla CTX-M-14), fluoroquinolone resistance determinant qnrB4, and trimethoprim-sulfamethoxazole resistance determinants dfrA17 and sul1. Mutations in ompK35, ompK37, prmA, pmrB, eptA, and parC were also found to contribute to resistance.
Resistome Analysis of Klebsiella pneumoniae Complex from Residential Aged Care Facilities Demonstrates Intra-facility Clonal Spread of Multidrug-Resistant Isolates.
The study identified several AMR genes and mutations in K. pneumoniae isolates from RACFs, including beta-lactamases (bla DHA-1, bla SHV-1, bla SHV-27, bla CTX-M-14), fluoroquinolone resistance determinant qnrB4, and trimethoprim-sulfamethoxazole resistance determinants dfrA17 and sul1. Mutations in ompK35, ompK37, prmA, pmrB, eptA, and parC were also found to contribute to resistance.
Assessment of three antibiotic combination regimens against Gram-negative bacteria causing neonatal sepsis in low- and middle-income countries.
The study identifies multiple AMR genes and mutations in Gram-negative bacteria causing neonatal sepsis in LMICs, including ESBLs, carbapenemases, and aminoglycoside-modifying enzymes, highlighting the high prevalence of multidrug resistance and the need for effective antibiotic combinations.
Assessment of three antibiotic combination regimens against Gram-negative bacteria causing neonatal sepsis in low- and middle-income countries.
The study identifies multiple AMR genes and mutations in Gram-negative bacteria causing neonatal sepsis in LMICs, including ESBLs, carbapenemases, and aminoglycoside-modifying enzymes, highlighting the high prevalence of multidrug resistance and the need for effective antibiotic combinations.
Genome analyses of colistin-resistant high-risk bla(NDM-5) producing Klebsiella pneumoniae ST147 and Pseudomonas aeruginosa ST235 and ST357 in clinical settings.
The study identifies mgrB deletion and mutations in pmrB, eptA, arnT, eptB, ompA, basS, basR, arnA, cprR, and cprS as key mechanisms of colistin resistance in K. pneumoniae and P. aeruginosa.
Synanthropic rodents and shrews are reservoirs of zoonotic bacterial pathogens and act as sentinels for antimicrobial resistance spillover in the environment: A study from Puducherry, India.
The study identified various AMR genes in bacterial isolates from synanthropic rodents and shrews, including mecA, mecC, blaTEM, blaSHV, blaCTX-M, tet, sul3, sul4, and qnrA, indicating their role as reservoirs of AMR pathogens.
Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization.
The study identified OXA-48 carbapenemase in 82.9% of K. pneumoniae isolates and NDM in 7.3%. bla CTX-M-15, bla SHV, and bla OXA-1 were also detected. Additionally, aac(6")-Ib, dfrA14, oqxA, and oqxB were found to confer resistance to aminoglycosides, trimethoprim, and fluoroquinolones.
Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: insights from a tertiary hospital in Southern Thailand.
The study identified bla TEM, bla CTX-M, and bla SHV genes as the primary resistance mechanisms in ESBL-producing E. coli and K. pneumoniae isolates in Southern Thailand.
Virulent-MDR-ESBL E. coli and Klebsiella pneumoniae report from North Sinai calves diarrhea and in vitro antimicrobial by Moringa oleifera.
The study identified blaTEM, blaSHV, and blaCTX-M9 genes in E. coli and K. pneumoniae isolates, along with the gyrA gene in K. pneumoniae, which contribute to multidrug resistance and extended-spectrum beta-lactamase (ESBL) production.
The Rising Tide of Antibiotic Resistance: A Study on Extended-Spectrum Beta-Lactamase and Carbapenem-Resistant Escherichia coli and Klebsiella pneumoniae.
The study identifies the presence of extended-spectrum beta-lactamase (ESBL)-producing and carbapenem-resistant Enterobacterales, specifically Escherichia coli and Klebsiella pneumoniae, in clinical settings in Pakistan. Key resistance genes include bla CTX-M, bla TEM, bla SHV, bla NDM, bla VIM, and bla IMP.
Characterization of Gram-negative Bloodstream Infections in Hospitalized Australian Children and Their Clinical Outcomes.
The study identified bla CTX-M-15 and bla SHV-12 as the most common extended-spectrum beta-lactamase genes in 3GCR Enterobacterales, contributing to third-generation cephalosporin resistance in hospitalized Australian children.
Four novel Acinetobacter lwoffii strains isolated from the milk of cows in China with subclinical mastitis.
Four Acinetobacter lwoffii strains were isolated from the milk of cows with subclinical mastitis in China. These strains exhibited multidrug resistance and carried 17 resistance genes, including beta-lactamase, aminoglycoside-modifying, fluoroquinolone, tetracycline, sulfonamide, and chloramphenicol resistance genes.
Study of the Genomic Characterization of Antibiotic-Resistant Escherichia Coli Isolated From Iraqi Patients with Urinary Tract Infections.
The study identified the presence of blaTEM, blaSHV, and blaCTXM genes in E. coli isolates from Iraqi patients with urinary tract infections, contributing to resistance against beta-lactam antibiotics.
Multi-drug resistant (MDR) Gram-negative pathogenic bacteria isolated from poultry in the Noakhali region of Bangladesh.
The study identified multiple AMR genes, including blaTEM, blaSHV, tetA, tetB, sul1, sul2, and mcr-1, in various multidrug-resistant Gram-negative bacteria isolated from poultry in Bangladesh. These genes conferred resistance to a wide range of antibiotics, highlighting the significant public health concerns associated with AMR in poultry.
Isolation and characterization of cefotaxime resistant Escherichia coli from household floors in rural Bangladesh.
The study identified bla CTX-M, bla TEM, and bla SHV genes as the primary contributors to cefotaxime resistance in E. coli isolates from household floors in rural Bangladesh. These genes were found in a high proportion of the isolates, with bla CTX-M being the most prevalent.
Antimicrobial Susceptibility and Genetic Epidemiology of Extended-Spectrum β-Lactamase-Positive Enterobacterales Clinical Isolates in Central Poland.
The study identified the prevalence of extended-spectrum beta-lactamase (ESβL) genes, including bla CTX-M, bla SHV, bla TEM, and bla VEB, in Enterobacterales clinical isolates from central Poland. The most common ESβL gene was bla CTX-M, and multiple resistance genes were often co-present in isolates.
Phenotypic and molecular characterization of multidrug-resistant Enterobacterales isolated from clinical samples in Palestine: a focus on extended-spectrum β-lactamase- and carbapenemase-producing isolates.
The study identified several AMR genes, including blaTEM, blaSHV, blaCTXm, blaNDM, blaOXA48, and blaKPC, which confer resistance to various beta-lactam antibiotics. These genes were detected in multidrug-resistant Enterobacterales isolates from clinical samples in Palestine.
Population genomics uncovers global distribution, antimicrobial resistance, and virulence genes of the opportunistic pathogen Klebsiella aerogenes.
The study characterizes various antimicrobial resistance genes in Klebsiella aerogenes, including beta-lactamases, carbapenemases, and colistin resistance genes, highlighting the diversity and global distribution of these resistance mechanisms.
Resolved genomes of wastewater ESBL-producing Escherichia coli and metagenomic analysis of source wastewater samples.
The study identified several beta-lactam resistance genes, including bla CTX-M-55, bla TEM-1, and bla SHV-2A, along with aminoglycoside, tetracycline, and sulfonamide resistance genes in ESBL-producing E. coli isolates from wastewater samples.
Molecular characterization of NDM and OXA-48-like-producing Klebsiella pneumoniae ST16 and hypervirulent ST337 clone among two patients; a case report.
The study identifies carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates carrying bla NDM, bla OXA-48-like, bla CTX-M, bla TEM, and bla SHV genes, along with virulence genes iucA, rmpA2, and rmpA in a hypervirulent ST337 clone. These isolates exhibited resistance to multiple antibiotics, including meropenem and colistin.
Evolution of extended-spectrum beta-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years.
The study identifies various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-15, blaCTX-M-27, blaCTX-M-14, and others, in ST131 E. coli isolates from a single hospital over 15 years. These genes are associated with resistance to multiple β-lactam antibiotics.
Evolution of extended-spectrum beta-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years.
The study identifies various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-15, blaCTX-M-27, blaCTX-M-14, and others, in ST131 E. coli isolates from a single hospital over 15 years. These genes are associated with resistance to multiple β-lactam antibiotics.
Evolution of the Antibiotic Resistance Levels, Multi-Resistance Patterns, and Presence of Antibiotic Resistance Genes in E. coli Isolates from the Feces of Breeding Hens during the Rearing Period.
The study identified several antibiotic resistance genes in E. coli isolates from breeding hens, including bla TEM, bla SHV, qnr B, and bla CMY-2. These genes were associated with resistance to various antibiotics, and their prevalence varied across different stages of hen rearing.
Phylogenetics and Mobilization of Genomic Traits of Cephalosporin-Resistant Escherichia coli Originated from Retail Meat.
The study identified multiple AMR genes in cephalosporin-resistant E. coli from retail meat, including bla CTX-M-1, bla SHV-12, bla CMY-2, and others, highlighting the role of mobile genetic elements in the spread of resistance.
An in-depth study on survival mechanism of bacterial isolates in disinfectants within the hospital environment.
The study identified multiple AMR genes, including blaDIM-1, qacE, and various efflux pump genes, in bacterial isolates from hospital disinfectants, indicating their adaptation to survive in disinfectant environments.
Molecular characterization of superbugs K. pneumoniae harboring extended-spectrum beta-lactamase (ESBL) and carbapenemase resistance genes among hospitalized patients in southwestern Iran, Western Asia.
The study identified several AMR genes in K. pneumoniae isolates, including blaSHV, blaTEM, blaCTX-M, blaOXA-48, and blaVIM, which confer resistance to various β-lactam antibiotics. These genes were detected in clinical isolates from hospitalized patients in southwestern Iran.
Assessment of the presence of multidrug-resistant Escherichia coli, Salmonella and Staphylococcus in chicken meat, eggs and faeces in Mymensingh division of Bangladesh.
The study identified multiple AMR genes in E. coli, Salmonella spp., and Staphylococcus aureus isolated from chicken meat, eggs, and faeces in Bangladesh, highlighting the presence of multidrug-resistant pathogens.
Culture and amplification-free nanopore sequencing for rapid detection of pathogens and antimicrobial resistance genes from urine.
The study demonstrates the successful detection of various antimicrobial resistance genes, including blaCTX-M-15, blaCTX-M-2, blaTEM-1, blaSHV, catA, tet(J), blaOXA-356, fosB, and mepA, using nanopore sequencing in spiked urine samples.
Antibiotic Resistance Genes and Plasmid Characteristics in Enterobacteriaceae Isolated from Fresh Produce
The study identified several antibiotic resistance genes on plasmids and chromosomes of Enterobacteriaceae strains isolated from fresh produce, highlighting the diversity of resistance mechanisms and the potential for horizontal gene transfer.
Evaluation of an expanded antibiotic resistance gene panel on prediction of antimicrobial susceptibility results for Gram-negative bacteria in blood cultures.
The study evaluated the QIAstat-Dx BCID panel for detecting antibiotic resistance genes in Gram-negative bacteria from blood cultures. It found that the panel effectively identified several resistance genes, including bla CTX-M, bla KPC, bla NDM, and others, which are crucial for predicting antimicrobial susceptibility. The panel showed high sensitivity and specificity for identifying resistance genes and predicting susceptibility, especially for beta-lactam antibiotics.
Investigation on the mechanisms of carbapenem resistance among the non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae.
The study identified non-carbapenemase β-lactamase genes and chromosomal mutations, including missense mutation or loss of ompK36 porin and frameshift missense mutation in efflux pump systems, as potential mechanisms of carbapenem resistance in NC-CRKP.
Investigation on the mechanisms of carbapenem resistance among the non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae.
The study identified non-carbapenemase β-lactamase genes and chromosomal mutations, including missense mutation or loss of ompK36 porin and frameshift missense mutation in efflux pump systems, as potential mechanisms of carbapenem resistance in NC-CRKP.
Investigation on the mechanisms of carbapenem resistance among the non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae.
The study identified non-carbapenemase β-lactamase genes and chromosomal mutations, including missense mutation or loss of ompK36 porin and frameshift missense mutation in efflux pump systems, as potential mechanisms of carbapenem resistance in NC-CRKP.
Predominance of enterotoxigenic Escherichia coli among ESBL/plasmid-mediated AmpC-producing strains isolated from diarrheic foals: a public health concern.
The study identified ESBL and pAmpC-producing E. coli strains in diarrheic foals, highlighting the presence of bla TEM, bla CTX-M, bla SHV, bla OXA, and bla CMY-2 genes, along with the heat-stable enterotoxin (ST) gene, indicating a public health concern.
High prevalence of multi-drug resistant organisms in the gut flora of healthy rural individuals in northern India.
The study found a high prevalence of multi-drug resistant organisms in the gut flora of healthy rural individuals in northern India, with a significant presence of ESBL and carbapenemase genes such as bla TEM, bla SHV, bla CTXM-1, and OXA-48.
Molecular epidemiological analysis of bla(NDM-5)-producing Klebsiella pneumoniae ST2407-K25 causing infection outbreaks in pediatric patients based on whole genome sequencing.
The study identifies bla_NDM-5 as the primary carbapenem resistance gene in CRKP ST2407-K25 isolates, along with additional resistance genes such as bla_DHA-1, bla_SHV-1, bla_CTX-M-14, qnrB4, sul1, and qacEΔ1. Mutations in ramR and acrR are linked to tigecycline resistance.
Wastewater and environmental sampling holds potential for antimicrobial resistance surveillance in food-producing animals - a pilot study in South African abattoirs.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-55, bla CTX-M-27, bla CTX-M-15, bla CTX-M-14, bla SHV-27, bla OXA-1, and bla EC, in ESBL-producing E. coli and K. pneumoniae isolates from South African abattoirs. These genes were associated with resistance to various beta-lactam antibiotics.
Diversity, functional classification and genotyping of SHV β-lactamases in Klebsiella pneumoniae.
Diversity, functional classification and genotyping of SHV β-lactamases in Klebsiella pneumoniae.
Enterobacterales Producing ESBLs and AmpC in Fresh Vegetables from Tebessa City, Algeria.
The study identified various ESBL genes, including bla CTX-M-79, bla CTX-M-107, bla CTX-M-117, bla TEM-112, bla TEM-125, bla TEM-194, and bla SHV-176, in Enterobacterales isolated from fresh vegetables in Tebessa, Algeria.
Prevalence and Molecular Epidemiology of Intestinal Colonization by Multidrug-Resistant Bacteria among Hematopoietic Stem-Cell Transplantation Recipients: A Bulgarian Single-Center Study.
The study identified several AMR genes including bla CTX-M, bla TEM, bla SHV, bla VIM, and vanA in multidrug-resistant bacteria isolated from HSCT recipients. These genes were associated with resistance to various antibiotics such as beta-lactams, carbapenems, and glycopeptides.
Prevalence, Characterization, and Epidemiological Relationships between ESBL and Carbapenemase-Producing Escherichia coli, Klebsiella pneumoniae, and Acinetobacter spp. Isolated from Humans and the Kitchen Environment of Two Greek Hospitals.
The study identified various beta-lactamase genes, including bla SHV, bla CTX-M, bla TEM, bla KPC, bla NDM, bla OXA-48, bla OXA-23, and bla OXA-51, in ESBL and carbapenemase-producing E. coli, K. pneumoniae, and Acinetobacter spp. isolates from hospital kitchens and staff.
Genomic Characterization of 16S rRNA Methyltransferase-Producing Enterobacterales Reveals the Emergence of Klebsiella pneumoniae ST6260 Harboring rmtF, rmtB, bla(NDM-5), bla(OXA-232) and bla(SFO-1) Genes in a Cancer Hospital in Bulgaria.
The study identifies the emergence of Klebsiella pneumoniae ST6260 harboring multiple AMR genes, including rmtF, rmtB, bla(NDM-5), bla(OXA-232), and bla(SFO-1), highlighting the complexity of resistance mechanisms in Enterobacterales.
Molecular Characterization of Carbapenem and Colistin Resistance in Klebsiella pneumoniae Isolates Obtained from Clinical Samples at a University Hospital Center in Algeria.
Distribution and Molecular Characterization of Antibiotic-Resistant Pseudomonas aeruginosa in Hospital Settings of Sulaymaniyah, Iraq.
The study identified the presence of bla CTX-M, bla SHV, qnr B, and bla ACC-1 genes among P. aeruginosa isolates, indicating the presence of multiple antibiotic resistance mechanisms.
A single-center analysis of clonal transmission of carbapenem-resistant Acinetobacter baumannii among intensive care unit patients during the COVID-19 pandemic.
The study identified multiple carbapenem-resistant Acinetobacter baumannii isolates carrying various resistance genes, including bla OXA-40, ISAba-1, int-2, bla OXA-23, bla NDM-1, and several ESBL genes. These findings highlight the complex resistance profiles and clonal transmission of CRAB in ICU settings during the COVID-19 pandemic.
Virulence and Antimicrobial Resistance Patterns of Salmonella spp. Recovered From Migratory and Captive Wild Birds.
The study identified the presence of AMR genes blaTEM, blaSHV, sul1, and tet(A) in Salmonella spp. recovered from migratory and captive wild birds, highlighting the potential for these birds to act as reservoirs of multidrug-resistant bacteria.
Overexpression of bla(SHV-12) caused by tandem amplification contributed to ceftazidime/avibactam resistance in hypervirulent and carbapenem-resistant Klebsiella pneumoniae.
The study identifies that overexpression of bla(SHV-12) due to tandem amplification leads to ceftazidime/avibactam resistance in hypervirulent and carbapenem-resistant Klebsiella pneumoniae.
Evaluation of the QIAstat-Dx BCID GN and GPF kits for direct identification and antimicrobial resistance prediction from blood culture bottles.
The QIAstat-Dx BCID GN and GPF kits showed high accuracy in detecting AMR genes such as blaZ, mecA, ermC, aac(6')-lb, ctx-m, ampC, shv, tem, tetM, and aac(6')/aph(2") in various bacteria, correlating well with phenotypic resistance results.
Prevalence and clinical significance of the genotypic carriage among ESBL phenotype-negative Escherichia coli and Klebsiella pneumoniae clinical isolates in bacteremia: a study in a Malaysian tertiary center.
The study identified the prevalence of bla CTX-M, bla SHV, bla TEM, and bla OXA-1 genes in ESBL phenotype-negative Escherichia coli and Klebsiella pneumoniae isolates from bacteremia cases in a Malaysian hospital. These genes were found to be associated with resistance to cephalosporins.
Antimicrobial Resistance and Pathotypes of Escherichia coli Isolates from Yellow-Legged Seagulls (Larus michahellis) in Central Italy.
The study identified various AMR genes in E. coli isolates from yellow-legged seagulls, including bla TEM, bla OXA-48, bla CMY2, bla SHV, and bla CTX, indicating the presence of multidrug-resistant and extensively drug-resistant strains.
Assessment of Bacterial Contamination and Antimicrobial Resistance of Escherichia coli Isolates from Slovak Dairy Farms.
The study identified several antimicrobial resistance genes in E. coli isolates from Slovak dairy farms, including bla TEM, bla SHV, bla CMY, sul 1, sul 2, tet B, and qnr S, which confer resistance to various antibiotics such as beta-lactams, sulfonamides, tetracyclines, and quinolones.
Genomic characterisation of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate assigned to a novel sequence type (6914).
The study reports the genomic characterization of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate, Cow102, which exhibits multidrug resistance. It identifies several resistance genes, including blaSHV-1, blaSHV-11, blaSHV-13, blaSHV-26, blaSHV-70, blaSHV-78, blaSHV-98, blaSHV-145, blaTEM-1B, aadA2, catA2, catII, dfrA16, fosA, oqxA, oqxB, sul1, sul2, and tet(D).
Genomic characterisation of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate assigned to a novel sequence type (6914).
The study reports the genomic characterization of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate, Cow102, which exhibits multidrug resistance. It identifies several resistance genes, including blaSHV-1, blaSHV-11, blaSHV-13, blaSHV-26, blaSHV-70, blaSHV-78, blaSHV-98, blaSHV-145, blaTEM-1B, aadA2, catA2, catII, dfrA16, fosA, oqxA, oqxB, sul1, sul2, and tet(D).
Genomic characterisation of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate assigned to a novel sequence type (6914).
The study reports the genomic characterization of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate, Cow102, which exhibits multidrug resistance. It identifies several resistance genes, including blaSHV-1, blaSHV-11, blaSHV-13, blaSHV-26, blaSHV-70, blaSHV-78, blaSHV-98, blaSHV-145, blaTEM-1B, aadA2, catA2, catII, dfrA16, fosA, oqxA, oqxB, sul1, sul2, and tet(D).
Genomic characterisation of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate assigned to a novel sequence type (6914).
The study reports the genomic characterization of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate, Cow102, which exhibits multidrug resistance. It identifies several resistance genes, including blaSHV-1, blaSHV-11, blaSHV-13, blaSHV-26, blaSHV-70, blaSHV-78, blaSHV-98, blaSHV-145, blaTEM-1B, aadA2, catA2, catII, dfrA16, fosA, oqxA, oqxB, sul1, sul2, and tet(D).
Genomic characterisation of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate assigned to a novel sequence type (6914).
The study reports the genomic characterization of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate, Cow102, which exhibits multidrug resistance. It identifies several resistance genes, including blaSHV-1, blaSHV-11, blaSHV-13, blaSHV-26, blaSHV-70, blaSHV-78, blaSHV-98, blaSHV-145, blaTEM-1B, aadA2, catA2, catII, dfrA16, fosA, oqxA, oqxB, sul1, sul2, and tet(D).
Genomic characterisation of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate assigned to a novel sequence type (6914).
The study reports the genomic characterization of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate, Cow102, which exhibits multidrug resistance. It identifies several resistance genes, including blaSHV-1, blaSHV-11, blaSHV-13, blaSHV-26, blaSHV-70, blaSHV-78, blaSHV-98, blaSHV-145, blaTEM-1B, aadA2, catA2, catII, dfrA16, fosA, oqxA, oqxB, sul1, sul2, and tet(D).
Genomic characterisation of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate assigned to a novel sequence type (6914).
The study reports the genomic characterization of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate, Cow102, which exhibits multidrug resistance. It identifies several resistance genes, including blaSHV-1, blaSHV-11, blaSHV-13, blaSHV-26, blaSHV-70, blaSHV-78, blaSHV-98, blaSHV-145, blaTEM-1B, aadA2, catA2, catII, dfrA16, fosA, oqxA, oqxB, sul1, sul2, and tet(D).
Genomic characterisation of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate assigned to a novel sequence type (6914).
The study reports the genomic characterization of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate, Cow102, which exhibits multidrug resistance. It identifies several resistance genes, including blaSHV-1, blaSHV-11, blaSHV-13, blaSHV-26, blaSHV-70, blaSHV-78, blaSHV-98, blaSHV-145, blaTEM-1B, aadA2, catA2, catII, dfrA16, fosA, oqxA, oqxB, sul1, sul2, and tet(D).
Performance of a hybrid capture-based target enrichment next-generation sequencing for the identification of respiratory pathogens and resistance-associated genes in patients with severe pneumonia.
The study evaluated the performance of RPIP for detecting respiratory pathogens and AMR genes in patients with severe pneumonia. RPIP showed superior sensitivity in detecting bacteria, viruses, and fungi compared to FilmArray-PN and culture methods. It identified several AMR genes, including bla CTX-M, bla OXA, bla CMY, bla OXA, bla SHV, bla IMP, bla NDM, and mec A/C & MREJ, which confer resistance to various antibiotics.
Survey in ruminants from Rwanda revealed high diversity and prevalence of extended-spectrum cephalosporin-resistant Enterobacterales.
The study identified various extended-spectrum cephalosporin-resistant Enterobacterales in ruminants from Rwanda, including multiple beta-lactamase genes such as bla CTX-M-15, bla TEM-1, and others, along with non-beta-lactam resistance genes like tet(A), sul2, and qnrS1.
Effect of Moringa oleifera seeds on the removal of pathogens and pharmaceutical residues in a domestic wastewater treatment plant by an interdisciplinary approach.
The study found that Moringa oleifera seeds (MOS) effectively reduced the abundance of antibiotic resistance genes (ARGs) such as bla CTX-M, bla SHV, and bla TEM in wastewater. MOS treatment significantly decreased the copy numbers of these genes, indicating potential for mitigating antibiotic resistance in wastewater treatment.
Escherichia coli from six European countries reveals differences in profile and distribution of critical antimicrobial resistance determinants within One Health compartments, 2013 to 2020.
The study identified various AMR genes in E. coli isolates from different sources in six European countries, highlighting differences in resistance profiles and the prevalence of specific resistance mechanisms such as beta-lactamases, quinolone resistance genes, and tetracycline resistance genes.
Prevalence and molecular characterization of ESBL-producing Escherichia coli isolated from broiler chicken and their respective farms environment in Malaysia.
The study identified bla TEM, bla CTX-M, and bla SHV as the primary ESBL genes in ESBL-producing E. coli isolates from broiler chickens and their farm environment in Malaysia. These genes conferred resistance to multiple antibiotics, including beta-lactams, tetracycline, and chloramphenicol.
Characterization of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Diarrhoeal Faeces from 0 to 5-Year-Old Children Attending Public Hospitals in Franceville, Gabon.
The study identified bla CTX-M-15 and bla SHV-12 as the primary extended-spectrum beta-lactamase genes in Escherichia coli isolates from children with diarrhea in Gabon, highlighting their role in antibiotic resistance.
Characteristics and antibiotic resistance patterns of urinary tract isolates in hospitalized and non-hospitalized patients: a cross-sectional study in Khartoum, Sudan.
The study identified CTX-M genes as a significant cause of extended-spectrum beta-lactamase (ESBL) production in urinary tract isolates, particularly in Escherichia coli and Klebsiella spp.
Genomic and phenotypic characterization of ST2012 clinical Klebsiella quasipneumoniae subsp. similipneumoniae harboring bla(NDM-1) in China.
The study identifies the presence of bla(NDM-1), bla(SHV-12), bla(OKP-B-2), oqxAB, and fosA in the clinical strain ACESH00366hy of Klebsiella quasipneumoniae subsp. similipneumoniae, highlighting its multidrug resistance profile.
The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes.
The study characterizes various resistance genes carried by incompatible plasmids in Gram-negative bacteria, highlighting their role in the spread of antibiotic resistance. Key genes include beta-lactamases like bla VIM-1, bla SHV-12, bla TEM-1B, and bla CTX-M-15, as well as sulfonamide resistance genes sul1 and sul2, tetracycline resistance gene tetA, and polymyxin resistance gene mcr-1.
Distinct molecular epidemiology of resistances to extended-spectrum cephalosporins and carbapenems in Enterobacter hormaechei in cats and dogs versus horses in France.
The study identified distinct molecular epidemiology of resistances to extended-spectrum cephalosporins and carbapenems in Enterobacter hormaechei from cats, dogs, and horses in France, highlighting the role of specific resistance genes such as bla SHV-12, bla CTX-M-15, and bla OXA-48, along with ampC overexpression and rmtB/armA-mediated aminoglycoside resistance.
Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307.
The study identifies the colistin resistance gene mcr-8.1 in multidrug-resistant Klebsiella pneumoniae ST307 isolates from Armenia, highlighting the emergence of this gene in the region.
Molecular and clinical insights into extended-spectrum beta-lactamase genes of Klebsiella pneumoniae isolated from neonatal sepsis in Ethiopia.
The study identified blaCTX-M, blaTEM, and blaSHV as the most prevalent extended-spectrum beta-lactamase genes in Klebsiella pneumoniae isolates from neonatal sepsis in Ethiopia, with significant correlations between blaSHV and neonatal mortality.
Phenotypic and genotypic landscape of antibiotic resistance through One Health approach in Sri Lanka: A systematic review.
The study identifies several antibiotic resistance genes, including tet-A, blaCTX-M, and blaSHV, which are prevalent in Escherichia coli and Klebsiella pneumoniae in Sri Lanka. These genes contribute to resistance against various antibiotics such as tetracycline, ceftazidime, ceftriaxone, and cefotaxime.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Prevalence and Zoonotic Risk of Multidrug-Resistant Escherichia coli in Bovine Subclinical Mastitis Milk: Insights Into the Virulence and Antimicrobial Resistance.
The study identified multidrug-resistant Escherichia coli in bovine subclinical mastitis milk, harboring genes blaSHV, CITM, tetA, and aac(3)-IV, which confer resistance to ampicillin, amoxicillin, tetracycline, and gentamycin, respectively. These isolates showed multidrug resistance and were closely related to disease-causing strains from various sources.
Prevalence and genetic characterization of clinically relevant extended-spectrum beta-lactamase-producing Enterobacterales in the Gulf Cooperation Council countries.
The study identifies bla CTX-M, bla TEM, and bla SHV as the most prevalent extended-spectrum beta-lactamase (ESBL) genes in Enterobacterales from the Gulf Cooperation Council (GCC) region, contributing to multidrug resistance. Additionally, bla OXA-48 and bla NDM-1 are noted as significant carbapenem-resistance genes.
Multidrug-resistant ST11-KL64 hypervirulent Klebsiella pneumoniae with multiple bla- genes isolated from children's blood.
Multidrug-resistant ST11-KL64 hypervirulent Klebsiella pneumoniae with multiple bla- genes isolated from children's blood.
Phenotypic and genotypic characterization of antimicrobial resistance and virulence profiles of Salmonella enterica serotypes isolated from necropsied horses in Kentucky.
The study identified several AMR genes in Salmonella enterica isolates from necropsied horses, including beta-lactamase genes (blaTEM, blaCTX-M, blaSHV2, blaOXA-9), aminoglycoside resistance gene (aacA[3]), sulfonamide resistance gene (sul2), amphenicol resistance gene (floR), tetracycline resistance gene (tetB), streptomycin resistance gene (strA), macrolide resistance gene (ermB2), and quinolone resistance gene (qnrB2). These genes were associated with resistance to multiple antibiotics, highlighting the presence of multidrug-resistant Salmonella strains.
Prevalence, Characterization, and Proteomic Relatedness Among β-Lactam-Resistant Bacteria Throughout the Poultry Production Chain in Greece.
The study identified various β-lactamase genes, including bla CTX-M, bla TEM, bla SHV, and bla OXA-1, in β-lactam-resistant bacteria from poultry farms and slaughterhouses in Greece.
Monitoring the Spread of Multidrug-Resistant Escherichia coli Throughout the Broiler Production Cycle.
The study identified the presence of ESBL genes (bla CTX-M, bla TEM, and bla SHV) in multidrug-resistant E. coli isolates from broiler farms in southern Brazil, highlighting the spread of resistance mechanisms in poultry production.
Assessment of Antibiotic Resistance Among Isolates of Klebsiella spp. and Raoultella spp. in Wildlife and Their Environment from Portugal: A Positive Epidemiologic Outcome.
The study identified a single multidrug-resistant (MDR) and extended-spectrum beta-lactamase (ESBL)-producing K. pneumoniae isolate from soil samples carrying multiple resistance genes, including bla CTX-M-15, bla TEM-1, bla SHV-28, bla OXA-1, qnr B1, oqx A, oqx B19, aac (6′)-Ibcr, sul 2, dfr A14, tet A, aph (6)-Id, aph (3″)-Ib, acr D, cat B3, and Int I1.
Molecular epidemiology of beta-lactamases in ceftriaxone-resistant Enterobacterales bloodstream infections in the mid-Atlantic United States.
The study identified various beta-lactamase genes including bla CTX-M, bla SHV, bla OXY, bla VEB, bla CMY-59, and bla DHA-1 in ceftriaxone-resistant Enterobacterales. Additionally, mutations in the promoter or attenuator regions of the c-ampC gene in E. coli were investigated, but they did not significantly contribute to ceftriaxone resistance.
Capture of mobile genetic elements following intercellular conjugation promotes the production of ST11-KL64 CR-hvKP.
The study characterizes the AMR genes and mutations involved in the conjugation process between hvKP and CRKP strains, highlighting the role of mobile genetic elements in the emergence of ST11-KL64 CR-hvKP strains.
Occurrence of "under-the-radar" antibiotic resistance in anthropogenically affected produce.
The study identifies several clinically relevant AMR genes, including beta-lactamases (bla CTX-M, bla TEM, bla SHV, bla VIM-1), aminoglycoside resistance genes (aadA5, dfrA17, mph(A)), quinolone resistance gene (qnrS1), and sulfonamide resistance gene (sul1), which were found in anthropogenically affected lettuce samples. These genes were associated with multidrug-resistant (MDR) Enterobacteriaceae and were capable of horizontal gene transfer.
Soil warming increases the active antibiotic resistome in the gut of invasive giant African snails.
Soil warming significantly increased the abundance and activity of beta-lactamase genes such as SHV, TEM, OCH, OKP, and LEN in the gut microbiome of giant African snails, contributing to increased antibiotic resistance.
Genomic analysis of Enterobacter cloacae complex from Southern Thailand reveals insights into multidrug resistance genotypes and genetic diversity.
The study identified multiple antimicrobial resistance genes in Enterobacter cloacae complex isolates from Southern Thailand, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and efflux pumps. Notably, the mcr-9 gene was found to confer colistin resistance.
Small Molecules from Medicinal Plant Iris tectorum as Histidine Kinase Inhibitor to Resensitize β-Lactam-Resistant Escherichia coli.
Iris tectorum extract resensitized β-lactam-resistant E. coli by downregulating ESBL gene expression and reducing histidine kinase phosphorylation levels.
Comprehensive genomic insights into a highly pathogenic clone ST656 of mcr8.1 containing multidrug-resistant Klebsiella pneumoniae from Bangladesh.
The study identifies multiple beta-lactamase genes (blaLAP-2, blaTEM-1, blaSHV-11, blaOXA-1) and the mcr8.1 gene, which confers resistance to colistin, in a multidrug-resistant K. pneumoniae ST656 isolate from Bangladesh. Additionally, the qacEdelta1 gene, which contributes to resistance against disinfectants and antibiotics, was detected.
Machine Learning-Based Detection of Heteroresistance to Piperacillin/Tazobactam in Escherichia coli
The study identifies beta-lactamase genes (blaTEM, blaCTX, blaSHV, ampC) as strong predictors of heteroresistance in E. coli, with the number of these genes correlating with resistance levels.
Circulation of a Unique Klebsiella pneumoniae Clone, ST147 NDM-1/OXA-48, in Two Diverse Hospitals in Calabria (Italy).
The study identifies multiple AMR genes, including bla OXA-48, bla NDM-1, bla CTX-M-15, and bla SHV, in K. pneumoniae strains from two hospitals in Calabria, Italy, highlighting the presence of multidrug-resistant clones.
Molecular epidemiology of Escherichia coli in bloodstream infections from a general hospital in Ningxia, China, 2022-2023.
The study identified bla CTX-M as the predominant ESBL gene and aac(6')-Ib-cr as the main quinolone resistance gene in E. coli causing bloodstream infections. Mutations in gyrA and parC were associated with quinolone resistance.
Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
The study identified various AMR genes and mutations in Salmonella Enteritidis isolates from Spain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and aminoglycoside resistance genes. Chromosomal mutations in the gyrA gene were also found to contribute to quinolone resistance.
Preliminary survey of biofilm forming, antibiotic resistant Escherichia coli in fishes from land based aquaculture systems and open water bodies in Bangladesh.
The study identified several antibiotic resistance genes, including blaTEM, blaSHV, blaCTX, sul1, and the biofilm-forming gene fimC, in Escherichia coli isolates from both wild and cultured fish in Bangladesh.
Rapid prediction of carbapenemases in Pseudomonas aeruginosa by imipenem/relebactam and MALDI-TOF MS.
The study characterizes various carbapenemase genes such as blaIMP-13, blaIMP-94, blaNDM-1, blaNDM-5, blaNDM-7, blaNDM-23, blaVIM-1, blaVIM-2, blaVIM-20, blaKPC-2, blaKPC-3, blaGES-1, blaGES-5, blaGES-7, blaGES-20, blaPER-1, blaVEB-1, blaCTX-M-15, blaCTX-M-9, blaSHV-12, blaFOX-4, blaCMY-2, blaDHA-1, blaOXA-2, blaOXA-10, blaOXA-14, blaOXA-15, and blaOXA-48 in Pseudomonas aeruginosa using MALDI-TOF MS hydrolysis assays.
Whole-Genome Sequencing of Extended-Spectrum beta-lactamase-Producing Klebsiella pneumoniae Isolated from Human Bloodstream Infections.
The study identified multiple AMR genes in ESBL-producing K. pneumoniae isolates, including blaCTX-M-15, blaKPC-3, and others conferring resistance to β-lactams, aminoglycosides, fluoroquinolones, sulfonamides, tetracyclines, and chloramphenicol.
Whole-Genome Sequencing of Extended-Spectrum beta-lactamase-Producing Klebsiella pneumoniae Isolated from Human Bloodstream Infections.
The study identified multiple AMR genes in ESBL-producing K. pneumoniae isolates, including blaCTX-M-15, blaKPC-3, and others conferring resistance to β-lactams, aminoglycosides, fluoroquinolones, sulfonamides, tetracyclines, and chloramphenicol.
Zoonotic potential of uropathogenic Escherichia coli lineages from companion animals.
The study identified several antimicrobial resistance genes in uropathogenic E. coli strains from companion animals, including blaTEM-1b, sul1, sul2, dfrA1_10, dfrA17_1, dfrA1_8, dfrA7_5, gyrA_S83L, tetA, tetB, aph(6)-Id, aph(3'')-Ib, ant(3'')-Ia, blaCTX-M-15, blaTEM-106, blaSHV-102, and blaCMY-2. These genes confer resistance to various antibiotics such as penicillins, sulfonamides, trimethoprim, quinolones, tetracyclines, streptomycin, and cephalosporins.
Functionally important residues from graph analysis of coevolved dynamic couplings.
The study introduces DyNoPy, a computational method that integrates residue coevolution analysis with molecular dynamics simulations to identify functionally important residues in beta-lactamases SHV-1 and PDC-3, which are crucial for antibiotic resistance.
Characterization of phenotypic and genotypic traits of Klebsiella pneumoniae strains resistant to 3rd generation cephalosporins in hospital settings: A case study in Ho Chi Minh City, Vietnam.
The study identifies the prevalence of AmpC beta-lactamase, ESBL, and carbapenemase genes in Klebsiella pneumoniae isolates from Ho Chi Minh City, Vietnam, highlighting the high resistance rates to third-generation cephalosporins and carbapenems.
Dissemination and phenotypic characterization of ESBL-producing Escherichia coli in Indonesia.
The study identified bla CTX-M, bla SHV, and bla TEM genes in ESBL-producing E. coli isolates from Indonesia, with bla CTX-M being the most prevalent. These genes confer resistance to cefotaxime and other antibiotics, highlighting the multidrug resistance of these isolates.
Identification of pandemic ST147, ESBL-type beta-lactamases, carbapenemases, and virulence factors in Klebsiella pneumoniae isolated from southern Peru.
The study identified ESBL genes (blaCTX-M, blaTEM, blaSHV) and carbapenemase genes (blaKPC-2, blaNDM-1) in K. pneumoniae isolates from Cusco, Peru. Additionally, aminoglycoside resistance genes (aadA1, aph(3')-Ib) and mutations in porin-coding genes (ompK36) and gyrA were found, contributing to multidrug resistance.
Molecular and Epidemiological Characterization of ESBL-producing Escherichia coli from Captive Wild Birds in Zoological Gardens in Nigeria.
The study identified ESBL-producing E. coli isolates from captive wild birds in Nigerian zoological gardens, highlighting the prevalence of bla CTX-M, bla SHV, and bla TEM genes, which confer resistance to beta-lactam antibiotics.
Molecular Characterization of Extended-Spectrum ß-Lactamases-Producing Escherichia coli Isolated from a Greek Food Testing Laboratory.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla SHV-12, and bla TEM-1B, in Escherichia coli isolates from food of animal origin in Greece. These genes were associated with resistance to third-generation cephalosporins and other beta-lactam antibiotics.
Antimicrobial Resistance Patterns of ESBL-Producing Escherichia coli in Dogs from Thailand: Evaluation of Algal Extracts as Novel Antimicrobial Agents.
The study identified bla TEM, bla CTX-M, and bla SHV as the primary beta-lactamase genes responsible for antimicrobial resistance in ESBL-producing E. coli isolates from dogs in Thailand.
Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?
The study identified multiple antibiotic resistance genes in clinical Klebsiella pneumoniae isolates, including bla TEM, bla SHV, bla CTX-M, and bla OXA families, as well as aminoglycoside, fluoroquinolone, and sulfonamide resistance genes. Effluent isolates showed fewer resistance genes and lower resistance levels compared to clinical isolates.
Antimicrobial Resistance in Nigeria: A Comprehensive Review of Environmental, Food, and Clinical Impacts
The study identifies several AMR genes, including bla CTX-M-15, floR, and various tetracycline and sulfonamide resistance genes, highlighting the spread of multidrug-resistant bacteria in Nigeria's environment, food supply chain, and clinical settings.
Antimicrobial resistance and genetic diversity of Escherichia coli isolated from marine bivalves.
The study identified several AMR genes in E. coli isolates from marine bivalves, including bla TEM, bla CTX-M9, bla SHV, bla CTX-M2, bla CTX-M8/25, qnrS, qnrB, sul1, and sul2. These genes were associated with resistance to various antibiotics, highlighting the role of marine environments in the dissemination of AMR.
Molecular Detection of Antibiotic Resistance Genes Using Respiratory Sample from Pneumonia Patients.
The study identified several antibiotic resistance genes in respiratory samples from pneumonia patients, including MecA, Tem, Oxa-48-like, Ctx-M-1, Oxa-51-like, VanA, Shv, and Ndm, which are associated with resistance to methicillin, beta-lactam antibiotics, carbapenems, and vancomycin.
Unravelling the Persistence of the Rare Serovar Salmonella Mikawasima in a Hospital Setting: A Whole-Genome Sequencing Study.
The study identifies aminoglycoside resistance genes (aac(6')-Iaa, aac(6')-Im, aph(2")-Ib), beta-lactamase genes (bla TEM-1B, bla SHV-2), and the tetracycline resistance gene tet(D) in Salmonella Mikawasima isolates, highlighting multidrug resistance in hospital settings.
Contamination of meat and its products by Pseudomonas species and assessment of the antibacterial effect of clove (Syzygium aromaticum) essential oil on multidrug-resistant P. aeruginosa.
The study identified the presence of blaSHV and Mcr1 genes in multidrug-resistant P. aeruginosa isolates from meat products, highlighting their role in resistance to several antibiotics.
Integrated genomic-epigenomic-transcriptomic analyses reveal adaptive mechanisms of colistin and carbapenem resistance in Klebsiella pneumoniae and Enterobacter isolates
The study identifies multiple AMR genes and mutations associated with colistin and carbapenem resistance in Klebsiella pneumoniae and Enterobacter isolates, including beta-lactamases, fosfomycin resistance genes, and efflux pumps. Mutations in ompK35 were found to contribute to carbapenem resistance.
From genomics to treatment: overcoming pan-drug-resistant Klebsiella pneumoniae in clinical settings.
The study identifies bla SHV-231 and bla NDM-5 as key drivers of pan-β-lactam resistance in K. pneumoniae, along with mutations in PBP2, PBP3, PmrB, and rpsJ that contribute to resistance against various antibiotics.
Detection of β-lactam resistance genes in Gram-negative bacteria from positive blood cultures using a microchip-based molecular assay.
The study evaluated the Alifax GNR microchip assay for detecting β-lactam resistance genes in Gram-negative bacteria from positive blood cultures, demonstrating high accuracy and broader coverage compared to existing methods.
Prevalence of ESBL-producing Escherichia coli in sub-Saharan Africa: A meta-analysis using a One Health approach.
The study identifies bla CTX-M-15 as the most frequently reported ESBL gene in sub-Saharan Africa, along with various other bla CTX-M, bla TEM, bla SHV, and bla OXA variants. These genes confer resistance to multiple beta-lactam antibiotics.
Prevalence of ESBL-producing Escherichia coli in sub-Saharan Africa: A meta-analysis using a One Health approach.
The study identifies bla CTX-M-15 as the most frequently reported ESBL gene in sub-Saharan Africa, along with various other bla CTX-M, bla TEM, bla SHV, and bla OXA variants. These genes confer resistance to multiple beta-lactam antibiotics.
Prevalence of ESBL-producing Escherichia coli in sub-Saharan Africa: A meta-analysis using a One Health approach.
The study identifies bla CTX-M-15 as the most frequently reported ESBL gene in sub-Saharan Africa, along with various other bla CTX-M, bla TEM, bla SHV, and bla OXA variants. These genes confer resistance to multiple beta-lactam antibiotics.
Prevalence of ESBL-producing Escherichia coli in sub-Saharan Africa: A meta-analysis using a One Health approach.
The study identifies bla CTX-M-15 as the most frequently reported ESBL gene in sub-Saharan Africa, along with various other bla CTX-M, bla TEM, bla SHV, and bla OXA variants. These genes confer resistance to multiple beta-lactam antibiotics.
Dissemination of KPC-2-producing carbapenem-resistant Klebsiella pneumoniae ST792 in Southern China.
The study identifies multiple AMR genes, including blaKPC-2, qnrS1, blaCTX-M-3, blaTEM-1B, and blaSHV-1, in KPC-2-producing carbapenem-resistant Klebsiella pneumoniae ST792 isolates, highlighting their multidrug-resistant phenotype and plasmid-mediated transmission.
Molecular epidemiology of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae bloodstream infections from Aberdeen, Scotland, and their comparison to isolates from England.
The study identified several AMR genes, including bla SHV, bla CTX-M, bla TEM, and mcr-9.1, in ESBL-producing Klebsiella pneumoniae isolates from Aberdeen, Scotland, and England. These genes conferred resistance to various antibiotics, including ceftazidime, cefotaxime, cefuroxime, and colistin.
Molecular detection of blaSHV gene in multidrug resistance of Klebsiella pneumoniae isolated from chicken egg shell swab from a traditional market in Surabaya.
The study identified the blaSHV gene in 71.42% of multidrug-resistant Klebsiella pneumoniae isolates from chicken eggshell swabs, indicating the presence of extended-spectrum beta-lactamase-producing bacteria in poultry products.
Molecular Identification and Antimicrobial Resistance Characteristics of Extended-Spectrum Beta-Lactamase Producing Klebsiella pneumoniae Isolated from Captive Wild and Migratory Birds.
The study identified extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae in captive wild and migratory birds in Bangladesh, highlighting the presence of resistance genes such as bla TEM-1&2, bla SHV-1, bla OXA-1,4&30, strA, tetA, and sul1, which contribute to multidrug resistance.
Detection and Characterization of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Raw Seafood From the Coastal Area of Bangladesh.
The study identified ESBL-producing E. coli in raw seafood from Bangladesh, with bla TEM, bla SHV, and bla CTX-M genes conferring resistance to beta-lactam antibiotics.
Prevalence of Biofilm-Forming, ESβLs and Metallo-β-lactamase Producing Gram-Negative MDR Bacteria in the Domestic and Hospital Wastewater of Aligarh City.
The study identified the prevalence of biofilm-forming, ESβL, and MβL-producing Gram-negative MDR bacteria in Aligarh's wastewater, highlighting the presence of bla-CTX-M, bla-NDM-1, and bla-SHV genes.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Antimicrobial resistance and beta-lactamase gene distribution among clinical isolates: a two-year cohort study.
The study identified several beta-lactamase genes, including blaCTX-M, blaSHV, blaTEM, blaOXA-48, blaKPC, blaVIM, and blaNDM, which are associated with resistance to various antibiotics in E. coli isolates.
Massive culture-based approach for the screening of AmpC, ESBL, and carbapenemase producers from rectal swabs.
The study presents a massive culture-based approach for the screening of AmpC, ESBL, and carbapenemase producers from rectal swabs, demonstrating improved specificity for detecting ESBL producers compared to conventional methods. It identifies various beta-lactamase genes, including bla CTX-M-1/2-like, bla CTX-M-8-like, bla CTX-M-9-like, bla SHV-like, bla TEM-like, bla GES-like, bla MOX, bla CIT, bla DHA, bla ACC, bla EBC, bla FOX, bla CMY-2, and bla NDM.
Genomic snapshot of Klebsiella spp. isolates from clinically ill animals reveal diverse lineages with limited relatedness to human isolates.
The study identified several AMR genes, including oqxAB, fosA, blaSHV, and mcr-8.1, in Klebsiella spp. isolates from clinically ill animals. These genes conferred resistance to quinolones, phenicols, fosfomycin, beta-lactams, and colistin, respectively.
Emerging Trends of Beta-Lactamases in Western Nepal: A Growing Public Health Concern.
The study identified the prevalence of ESBL, AmpC, and carbapenemase-producing clinical isolates of Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. ESBL production was the predominant mechanism of resistance to beta-lactam drugs, followed by AmpC and carbapenemase production.
Molecular characterization and prevalence of plasmids co-harbouring mcr and ESBL genes.
The study identifies mcr-9 and mcr-4.3 genes as the primary colistin resistance genes in ESBL-producing Enterobacterales isolates, with mcr-9 being the most prevalent. It also characterizes plasmids co-harbouring these genes, highlighting their IncHI2 replicon type and the presence of ESBL genes like bla CTX-M-9 and bla SHV-12.
The Microbiological Characteristics and Genomic Surveillance of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Clinical Samples.
The study identified multiple carbapenemase genes, including bla NDM-5, bla NDM-1, and bla OXA-232, as well as extended-spectrum beta-lactamases like bla CTX-M-15. Mutations in porin genes ompK36 and ompK37, and regulatory genes acrR and ramR, were associated with reduced susceptibility to carbapenems, cephalosporins, fluoroquinolones, and tigecycline.
Isolation and Molecular Characterization of Antimicrobial-Resistant Bacteria from Vegetable Foods.
The study identified several antimicrobial resistance genes in Enterobacteriaceae isolated from vegetables, including TEM, CTX-M IV, SHV, OXA, CMY II, DHA, tetA, tetW, sul-I, and qnrD, which confer resistance to beta-lactams, tetracyclines, sulfonamides, and quinolones.
Genomic characterization of an ESBL-producing Klebsiella pneumoniae ST37 recovered from a hospitalized patient in Armenia.
The study identified several AMR genes in the ESBL-producing K. pneumoniae ST37 isolate ARM02, including blaTEM-1D, blaSHV-11, dfrA14, sul2, strA, strB, and blaCTX-M-15, which were directly linked to the observed resistance phenotypes.
Whole-Genome Sequencing of Klebsiella quasipneumoniae subsp. similipneumoniae Isolated from a Patient with Pneumonia.
The study identifies several AMR genes in a multidrug-resistant K. quasipneumoniae subsp. similipneumoniae isolate, including blaSHV-18, blaOXA-2, sul1, ant(2")-Ia, and ompK36, which contribute to resistance against various antibiotics.
Extended spectrum β-lactamase-producing Enterobacterales in live and dead birds from rural poultry farms and urban live bird markets of Bangladesh.
The study identified blaTEM, blaSHV, and blaCTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) resistance in Enterobacterales from poultry in Bangladesh. ESBL-producing E. coli was the most prevalent species, with high resistance rates to multiple antibiotic classes.
Monitoring, surveillance, antimicrobial resistance and genetic diversity analysis of non-typhoidal Salmonella in South Africa from 1960-2023 from animal and animal products.
The study identified several AMR genes in Salmonella isolates from South Africa, including blaPSE, blaSHV, qnrS, tetA, qnrA, cat1, blaCMY-2, and qnrB, which were associated with resistance to various antibiotics such as ceftriaxone, chloramphenicol, tetracycline, and others.
Uncovering hidden threats: prevalence, antibiotic resistance and virulence gene profiles of Escherichia coli strains isolated from Testudines and their aquatic habitats.
The study identified various antibiotic resistance genes in E. coli isolates from Testudines and their aquatic habitats, including mcr-1, mcr-2, mcr-4, bla TEM, bla SHV, qnrA, qnrD, eaeA, virF, stx1, and stx2. These genes confer resistance to colistin, cephalothin, ampicillin, ciprofloxacin, and nalidixic acid, highlighting the presence of multidrug-resistant E. coli in wild reptiles and their environments.
Whole-genome sequencing and bioinformatic tools powered by machine learning to identify antibiotic-resistant genes and virulence factors in Escherichia coli from sepsis.
The study identified several known and novel antibiotic-resistant genes in E. coli isolates from sepsis patients using whole-genome sequencing and machine learning. Key findings include the presence of blaCTX-M, blaSHV, blaTEM, aac(6')-Ib, aadA, qnrS1, ermB, mexAB-OprM, acrAB-TolC, and oqxAB genes, which confer resistance to various antibiotics.
Tracking Enterobacteria, microbiomes, and antibiotic resistance genes from waste to soil with repeated compost applications.
The study identifies several AMR genes including bla CTX-M, bla TEM-1B, bla SHV-12, qnr A, qnr B, aac(6')-Ib, sul 1, sul 2, intI 1, and intI 2 in Enterobacteria from composts and raw waste, highlighting their persistence and potential spread in tropical soils.
A novel broad host range phage phiA85 displays a synergistic effect with antibiotics targeting carbapenem-resistant Klebsiella pneumoniae.
The study identified a novel broad host range phage phiA85 that effectively targets multiple carbapenem-resistant Klebsiella pneumoniae (CRKP) strains. Additionally, the phage phiA85 in combination with antibiotics showed synergistic effects against CRKP in vitro and in vivo.
Identification and preclinical efficacy evaluation of two lytic bacteriophages targeting highly virulent and multidrug-resistant Klebsiella pneumoniae.
The study identifies two lytic bacteriophages, vB_KpnP_XY3 and vB_KpnP_XY4, effective against multidrug-resistant Klebsiella pneumoniae. These phages demonstrate broad temperature and pH tolerance, chloroform resistance, and potent lytic activity against MDR K. pneumoniae strains, significantly reducing bacterial load and inflammation in a murine pneumonia model.
Low prevalence but high resistance of Extended Spectrum Beta-lactamase producing Klebsiella pneumoniae isolated from Hospitals in the Ashanti Region of Ghana.
The study identified blaCTX-M, blaSHV, and blaTEM genes in ESBL-producing Klebsiella pneumoniae isolates, contributing to high resistance to cephalosporins.
The bacterial etiology and antimicrobial susceptibility of lower respiratory tract infections in Vietnam.
The study identified several AMR genes, including bla CTX-M-1, bla CTX-M-9, bla TEM, bla SHV, bla OXA-23, bla OXA-48, bla NDM, bla KPC, and mecA, which were associated with resistance to various antibiotics in different bacterial pathogens.
One health approach unravels worrying antimicrobial resistance patterns: A cross-sectional study in Kisii, Kenya.
The study identified several AMR genes, including blaTEM, blaOXA-48, blaSHV, blaCTXM-15, blaCTXM-8, blaCTXM-1, blaCTXM-9, blaVIM, and blaNDM, which were associated with resistance to various antibiotics in Enterobacterales isolates from human, animal, and environmental samples in Kisii, Kenya.
The investigation of bacteria in the oral of Trichomonas gallinae infected pigeons and the antibiotic resistance analysis of Klebsiella pneumoniae clinical isolates from farm pigeons in Shandong Province of China.
The study identified multiple antibiotic resistance genes in Klebsiella pneumoniae isolates from farm pigeons in Shandong Province, including bla-SHV, bla-TEM, bla-CTX-M-9, qnrB, tetA, and aac(6')-Ib, highlighting the presence of multidrug-resistant strains.
An NGS-assisted diagnostic workflow for culture-independent detection of bloodstream pathogens and prediction of antimicrobial resistances in sepsis.
The study evaluated the diagnostic performance of PISTE™ technology, an NGS-based workflow for detecting bloodstream pathogens and predicting antimicrobial resistance. It showed high accuracy in identifying pathogens and predicting resistance genes, including beta-lactamases, carbapenemases, aminoglycoside modifying enzymes, tetracycline efflux pumps, and quinolone resistance proteins.
Phenotypic, Targeted Genotypic, and Antimicrobial Susceptibility Profiling of Extended-Spectrum β-Lactamase Production and Exclusive bla(OXA)-48 Gene Detection in Escherichia coli and Klebsiella pneumoniae Isolates From a South Lebanese Hospital.
The study identified blaCTX-M, blaTEM, and blaSHV as the most prevalent ESBL genes in E. coli and K. pneumoniae isolates, while blaOXA-48 was detected in a small proportion of CRE isolates.
Extended-Spectrum beta-lactamase-Producing Klebsiella pneumoniae in Southwest China: Molecular Characteristics and Risk Factors of Bloodstream Infections.
The study identified bla TEM, bla SHV, and bla CTX-M genes, with bla CTX-M-15 being the predominant variant in ESBL-producing Klebsiella pneumoniae isolates from bloodstream infections in Southwest China.
Antibiotic resistance and novel Sequence Types of Klebsiella spp. in human, animal, and food sources: a One Health perspective from Northern Nigeria.
The study identified various AMR genes in Klebsiella spp. isolates from human, animal, and food sources, including strB, qnrS1, sul2, tetA, dfrA14, blaTEM-1, and blaSHV-11, which conferred resistance to multiple antibiotics.
Antimicrobial Resistant Salmonella in Canal Water in Bangkok, Thailand: Survey Results Between 2016 and 2019.
The study identified the presence of extended-spectrum beta-lactamase (ESBL) genes, primarily blaCTX-M, in Salmonella isolates from Bangkok's canal water, along with class 1 integrons, highlighting the spread of antimicrobial resistance in urban environments.
Phenotypic and Molecular Study of Multidrug-Resistant Escherichia coli Isolates Expressing Diverse Resistance and Virulence Genes from Broilers in Tunisia.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from broilers in Tunisia, including bla CTX-M-G1, bla TEM, bla SHV, bla OXA-48, bla IMP, mcr-1, aadA-1, aadA-5, aac(6)-Ib-cr, qnrS, and qnrB.
Prevalence, Antibiotic Resistance, and Biofilm Formation of Proteus mirabilis in Dairy Products: Implications for Veterinary and Public Health.
The study identified several antibiotic resistance genes in Proteus mirabilis isolates from dairy products, including blaCTX-M, blaSHV, blaTEM, aac(3)IIa, and Sul1, which confer resistance to various antibiotics such as cephalothin, gentamicin, and cotrimoxazole.
Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.
The study identifies 42 antimicrobial resistance (AMR) genes in the pan-drug resistant Klebsiella pneumoniae isolate KPNW, including beta-lactamases (bla CTX-M-15, bla NDM-1, bla OXA-1, bla TEM-63, bla TEM-104, bla SHV-28), tetracycline resistance genes (tet(A)), and efflux pump genes (oqxA, oqxB, marA, marR, ompK37, pbp3, crp, h-ns, kpnG, kpnH, parC, rsmA). Additionally, the isolate shows resistance to polymyxin B and colistin through modifications in lipid A (eptB, arnT, lptD, msbA, vanG) and other mechanisms.
Antibiotic resistance in white stork cloaca and environmental samples
The study identified various antibiotic resistance genes in bacterial isolates from white stork cloaca and environmental samples, highlighting the presence of resistance mechanisms against beta-lactams, aminoglycosides, quinolones, and polymyxins.
Genetic diversity, virulence genes, antimicrobial resistance, and biofilm formation of Klebsiella pneumoniae isolated from bovine mastitis milk in South Korea.
The study identified several AMR genes in K. pneumoniae isolates from bovine mastitis milk in South Korea, including blaSHV, strA, strB, sulI, sulII, tetA, tetB, tetC, floR, dfrXII, blaTEM, blaCTX-M, and blaOXA, which confer resistance to various antibiotics such as ampicillin, gentamicin, trimethoprim/sulfamethoxazole, tetracycline, chloramphenicol, and others.
Antimicrobial resistance profiles and genomic insights of phenotypically extended spectrum beta-lactamase-positive Klebsiella pneumoniae from cattle farms.
The study identifies multiple AMR genes, including bla TEM, bla SHV, bla AmpC, qnrS, and tetA, in phenotypically ESBL-positive K. pneumoniae isolates from cattle farms in Punjab, India. These genes confer resistance to various antibiotics, highlighting the potential for AMR spread in livestock environments.
ESBL-producing Klebsiella pneumoniae gut colonisation and subsequent health-care associated bacteraemia in preterm newborns: a descriptive cohort with nested case-control study.
The study identifies several AMR genes, including bla CTX-M-1, bla SHV, bla TEM, bla OXA-48, bla NDM, and bla VIM, in ESBL-producing K. pneumoniae isolates from preterm neonates. These genes confer resistance to various beta-lactam antibiotics and carbapenems.
Environmental Dissemination of Multidrug-Resistant Gram-Negative Pathogens in Djibouti's Wastewaters.
The study identifies multidrug-resistant gram-negative bacteria in Djibouti's wastewaters, highlighting the presence of ESBL gene bla CTX-M-15 and carbapenemase gene bla OXA-48, indicating significant antibiotic resistance mechanisms.
Environmental Dissemination of Multidrug-Resistant Gram-Negative Pathogens in Djibouti's Wastewaters.
The study identifies multidrug-resistant gram-negative bacteria in Djibouti's wastewaters, highlighting the presence of ESBL gene bla CTX-M-15 and carbapenemase gene bla OXA-48, indicating significant antibiotic resistance mechanisms.
Environmental Dissemination of Multidrug-Resistant Gram-Negative Pathogens in Djibouti's Wastewaters.
The study identifies multidrug-resistant gram-negative bacteria in Djibouti's wastewaters, highlighting the presence of ESBL gene bla CTX-M-15 and carbapenemase gene bla OXA-48, indicating significant antibiotic resistance mechanisms.
Resistance, virulence and genetic diversity of Salmonella Typhimurium in South Africa (1999-2021).
The study identified several AMR genes in Salmonella Typhimurium isolates from South Africa, including beta-lactamases (bla PSE, bla CMY-2, bla TEM, bla SHV), sulfonamide resistance genes (sul1, sul2, sul3), fluoroquinolone resistance genes (qnrA, qnrB, qnrS), tetracycline resistance genes (tetA, tetB), and trimethoprim resistance genes (dfrXI, dfrXII).
Antibiogram and Detection of Resistant Genes in Escherichia coli Isolated From Meat and Meat Products of Kathmandu, Nepal.
The study identified ESBL genes bla CTX and bla TEM-52, and colistin resistance gene mcr-1 in E. coli isolates from meat and meat products in Kathmandu, Nepal.
Rapid detection of gram-negative antimicrobial resistance determinants directly from positive blood culture broths using a multiplex PCR system.
The study evaluated the BIOFIRE FILMARRAY Antimicrobial Resistance (AMR) Panel for rapid detection of AMR genes in gram-negative bacteria from positive blood culture broths. It identified several AMR genes, including beta-lactamases (TEM-1, SHV-1, CTX-M, KPC, NDM, OXA-1, OXA-23), AmpC beta-lactamases (CMY/MOX, DHA), aminoglycoside modifying enzymes (AAC(6′)-Ib-cr), and fluoroquinolone resistance mutations (ParC-S80I, GyrA-S83F/I/L).
Plasmid-mediated quinolone resistance among extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolated from hospitalized patients, hospital environment and wastewaters in Cameroon.
The study identified aac-(6')-Ib-cr, qnrS, blaCTX-M, blaTEM, and blaSHV as the primary AMR genes in ESBL-producing E. coli and K. pneumoniae in Cameroon. These genes were associated with resistance to fluoroquinolones and beta-lactam antibiotics.
Extended spectrum beta-lactamase and integron genes among Shigella flexneri and Shigella sonnei isolated from children with diarrhea in shiraz, Southwest Iran.
The study identified the presence of ESBL genes bla CTX−M, bla TEM, and bla SHV, along with integron classes 1 and 2, in Shigella flexneri and Shigella sonnei isolates, highlighting a high prevalence of multidrug-resistant strains.
Molecular characterization of antimicrobial resistance genes and plasmid profiles in enterobacterales isolated from urinary tract infections in rural outpatient women in Otavalo, Ecuador.
The study identified four prevalent antibiotic resistance genes, with bla TEM being the most common (87.01% of isolates), followed by bla CTX−M−1 (44.16%), bla SHV (18.83%), and bla CTX−M−9 (13.64%).
A beta-lactamase inhibitory protein mutant displays high potency and a broad inhibition profile due to an altered binding mode with beta-lactamases.
The BLIP E73W mutant exhibits high potency and a broad inhibition profile against class A beta-lactamases, achieved through a distinct binding mode that allows it to inhibit multiple beta-lactamase variants effectively.
Prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae isolated from animals in Bangladesh: A systematic review and meta-analysis.
The study identified bla CTX-M, bla TEM, and bla SHV as the most prevalent ESBL genes in Enterobacteriaceae isolates from animals in Bangladesh, highlighting their association with multidrug resistance.
Exploring the Relationship Between Biofilm Formation and Antibiotic Resistance Genes in Clinically Isolated Klebsiella pneumoniae.
The study identifies the presence of biofilm-associated gene mrkA and antibiotic resistance genes blaSHV and blaTEM in clinically isolated Klebsiella pneumoniae. It reveals a significant association between the presence of mrkA and elevated expression of blaSHV, suggesting a potential link between biofilm formation and antibiotic resistance.
Pathogenic potential of amoxicillin-clavulanic acid resistant Klebsiella pneumoniae isolated from aquatic environment: a study of multidrug resistance and virulence.
The study identified several AMR genes in AMC-resistant K. pneumoniae isolates from aquatic environments, including bla TEM, bla SHV, bla CTX-M, bla NDM, bla OXA-48, bla CMY, qnr S, qnr B, tet A, tet B, sul 1, dfr A12, intl 1, intl 2, mrk D, ecp A, and iuc C. These genes were associated with resistance to multiple antibiotics, highlighting the complex resistance profiles of these isolates.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
Novel antimicrobial strategy: native postbiotics synergize with antibiotics to overcome resistance in Klebsiella pneumoniae.
Native postbiotics synergize with antibiotics to overcome resistance in Klebsiella pneumoniae by reducing the expression of resistance genes such as bla NDM, bla CTX, bla TEM, and bla SHV.
Genomic epidemiology of strains currently and formerly classified as Enterobacter spp. recovered from equine necropsy samples.
The study identified several AMR genes in Enterobacter spp. strains, including beta-lactamases (blaDHA-1, blaOXA-1, blaSHV-12, blaTEM-1B), aminoglycoside resistance genes (aac(6')-ib_cr), quinolone resistance genes (qnrB2, qnrB4), and fosfomycin resistance genes (fosA, fosA2). These genes contribute to resistance against multiple antibiotic classes.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
Genomic characterization of Klebsiella pneumoniae clinical isolates from cancer patients: resistance profiles, virulence factors, and sequence typing.
The study identified several AMR genes in K. pneumoniae isolates from cancer patients, including genes conferring resistance to trimethoprim-sulfamethoxazole, tobramycin, levofloxacin, and carbapenems. Key resistance genes included sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA27, aadA16, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aph(4)-Ia, ACC(3)-IId, ACC(3)-IIV, AAC(6')-Ib-cr, QnrS1, QnrB17, QnrB20, QnrB4, CTX-M, SHV, TEM, DHA-1, LAP-2, bla_kpc-1, bla_ndm-5, and bla_oxa-10.
Frequency of Pseudomonas's Antibiotic Resistance and Virulence Genes in Poultry Meat.
The study identified several antibiotic resistance genes, including bla TEM, bla SHV, bla DHA, and others, in Pseudomonas aeruginosa isolates from poultry meat. Additionally, various virulence genes such as exoT, exoY, exoS, and exoU were detected.
Molecular characterization of Salmonella isolates from poultry in Egypt: Detection of virulence, ESBLs genes and antimicrobial resistance profiling.
The study identified the presence of ESBL genes (blaTEM, blaCTX-M, and blaSHV) in Salmonella isolates from poultry in Egypt, which were associated with high resistance to beta-lactam antibiotics. All isolates were resistant to ceftazidime, cefepime, and erythromycin, with high resistance rates observed against amoxicillin, amoxicillin-clavulanic acid, ciprofloxacin, and doxycycline.
Isolation and characterization of Salmonella enterica serovars from poultry in Egypt: a comprehensive genetic analysis of ESBLs, MCR, integron and other resistance genes.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from poultry in Egypt, including bla TEM, bla SHV, bla CTX-M, bla OXA-10, bla CMY-2, mcr-1, and intI 1. These genes were associated with resistance to various antibiotics, highlighting the presence of multidrug-resistant strains.
Ultrasound-Assisted Extraction: Unlocking the Antibacterial Potential of Coptis chinensis Franch. Against ESBL-Producing Enterobacterales.
The study identifies multiple beta-lactamase resistance genes in ESBL-PE strains, including blaCTX-M-14, blaCTX-M-1, blaCTX-M-3, blaCTX-M-15, blaCTX-M-65, blaSHV, blaTEM, blaEC, blaACC, blaCMY, blaACT, blaDHA, and efflux pump genes such as acrF, emrD, mdtM, silA, kdeA, oqxA, oqxB, arsB, oqxA10, oqxB5, oqxB19, arsA, and hugA, which contribute to multidrug resistance in these isolates.
Genomics, population dynamics, immune evasion and resistance determinants foster the competence and global dissemination of Klebsiella pneumoniae.
The paper identifies several beta-lactamase genes, including blaKPC, blaNDM-1, blaOXA-48, blaCTX-M-15, blaSHV-11, blaKPC-2, blaKPC-3, blaOXA-9, blaOXA-48, blaOXA-181, blaOXA-232, and blaNDM, which confer resistance to carbapenems and other antibiotics in Klebsiella pneumoniae.
Whole genome sequencing of a hypermucoviscous, multidrug-resistant Klebsiella pneumoniae subsp. pneumoniae K219 isolated from human sputum.
The study identified four key antibiotic resistance genes in the genome of K. pneumoniae subsp. pneumoniae K219: fosA, blaNDM-7, blaSHV-80, and blaTEM-1B, which confer resistance to various antibiotics.
Effect of surgical antimicrobial prophylaxis duration for colic surgery on complications and resistome.
The study found that extending surgical antimicrobial prophylaxis beyond 24 hours did not increase postoperative complications but led to a higher abundance of beta-lactam resistance genes, including TEM, BlaZ, SHV, CfxA, and PBP2, as well as aminoglycoside-modifying enzymes like AAC(6'), ANT(3"), ANT(6), APH(2"), APH(3'), APH(3"), and APH(6) in the fecal resistome of horses.
Alarming colistin and carbapenem resistance in Klebsiella pneumoniae: molecular insights from Tehran hospitals, Iran.
The study identified high prevalence of carbapenem and colistin resistance in Klebsiella pneumoniae isolates from Tehran hospitals, with bla TEM, bla SHV, bla CTX-M, bla NDM, and bla OXA-48 being the major resistance genes. Colistin resistance was observed in 16.7% of isolates, but no mcr genes were detected.
Antimicrobial resistance, virulence defects, and evolutionary dynamics of multidrug-resistant Klebsiella pneumoniae from human and animal hosts in Central China.
The study identifies multiple AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae isolates from human and animal hosts in Central China, highlighting the role of plasmid-borne resistance genes and genetic variations affecting virulence.
Precise species identification and whole-genome sequencing analysis of Enterobacter cloacae complex causing bloodstream infections in China.
The study identified various AMR genes in Enterobacter cloacae complex (ECC) isolates, including bla ACT, bla NDM, and mcr-10, which confer resistance to beta-lactams, carbapenems, and polymyxins, respectively. It also found that E. roggenkampii was the most common species among carbapenem-resistant isolates and showed high resistance to both carbapenems and colistin.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
In Vitro Evaluation of Fosfomycin Combinations Against Metallo-β-Lactamase-Producing Klebsiella pneumoniae and Pseudomonas aeruginosa Clinical Isolates.
The study evaluated the in vitro synergistic activity of fosfomycin (FOS) in combination with other antimicrobials against MBL-producing K. pneumoniae and P. aeruginosa. It found that FOS combinations showed significant synergy, particularly with CAZ-AVI and COL, suggesting their potential utility in treating infections caused by MBL-producing bacteria.
Prevalence of ESBL-Producing Escherichia coli on Neck Skin in Slaughtered Broilers Raised on Conventional, Antibiotic-Free, and Organic Farms.
The study identified various ESBL and AmpC genes, including bla CTX-M-1, bla CTX-M-9, bla TEM, bla SHV, bla OXA, bla CIT, bla MOX, bla DHA, bla ACC, bla EBC, and bla FOX, in ESBL-producing E. coli isolates from broiler neck skin. These genes were associated with resistance to beta-lactam antibiotics such as cefotaxime, ceftazidime, and cefoxitin.
Virulence Gene Profiles of Extended-Spectrum beta-lactamase (ESBL)-Producing Escherichia coli Isolated from Turkeys in Hungary: A Whole-Genome Sequencing Study.
The study identified ESBL-producing E. coli strains from turkeys carrying various virulence genes, including those associated with adhesion, biofilm formation, and iron acquisition, highlighting their potential to cause disease and resist treatment.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
The study identified mcr-1.1-harboring multidrug-resistant E. coli isolates from chicken in the UAE, highlighting the presence of various AMR genes and mutations contributing to resistance against multiple antibiotics, including colistin, beta-lactams, quinolones, and aminoglycosides.
Novel insights into antimicrobial-resistant, virulent and biofilm-forming Salmonella: Molecular and phenotypic evidence from duck at the human-animal-environment interface.
The study identifies multiple ESBL genes (bla TEM, bla SHV, bla CTX-M, bla AmpC) and biofilm-related genes (csgA, rpoS, rcsA, sdiA) in Salmonella isolates from ducks, highlighting their role in antimicrobial resistance and virulence.
Novel insights into antimicrobial-resistant, virulent and biofilm-forming Salmonella: Molecular and phenotypic evidence from duck at the human-animal-environment interface.
The study identifies multiple ESBL genes (bla TEM, bla SHV, bla CTX-M, bla AmpC) and biofilm-related genes (csgA, rpoS, rcsA, sdiA) in Salmonella isolates from ducks, highlighting their role in antimicrobial resistance and virulence.
Novel insights into antimicrobial-resistant, virulent and biofilm-forming Salmonella: Molecular and phenotypic evidence from duck at the human-animal-environment interface.
The study identifies multiple ESBL genes (bla TEM, bla SHV, bla CTX-M, bla AmpC) and biofilm-related genes (csgA, rpoS, rcsA, sdiA) in Salmonella isolates from ducks, highlighting their role in antimicrobial resistance and virulence.
Novel insights into antimicrobial-resistant, virulent and biofilm-forming Salmonella: Molecular and phenotypic evidence from duck at the human-animal-environment interface.
The study identifies multiple ESBL genes (bla TEM, bla SHV, bla CTX-M, bla AmpC) and biofilm-related genes (csgA, rpoS, rcsA, sdiA) in Salmonella isolates from ducks, highlighting their role in antimicrobial resistance and virulence.
Novel insights into antimicrobial-resistant, virulent and biofilm-forming Salmonella: Molecular and phenotypic evidence from duck at the human-animal-environment interface.
The study identifies multiple ESBL genes (bla TEM, bla SHV, bla CTX-M, bla AmpC) and biofilm-related genes (csgA, rpoS, rcsA, sdiA) in Salmonella isolates from ducks, highlighting their role in antimicrobial resistance and virulence.
Novel insights into antimicrobial-resistant, virulent and biofilm-forming Salmonella: Molecular and phenotypic evidence from duck at the human-animal-environment interface.
The study identifies multiple ESBL genes (bla TEM, bla SHV, bla CTX-M, bla AmpC) and biofilm-related genes (csgA, rpoS, rcsA, sdiA) in Salmonella isolates from ducks, highlighting their role in antimicrobial resistance and virulence.
Novel insights into antimicrobial-resistant, virulent and biofilm-forming Salmonella: Molecular and phenotypic evidence from duck at the human-animal-environment interface.
The study identifies multiple ESBL genes (bla TEM, bla SHV, bla CTX-M, bla AmpC) and biofilm-related genes (csgA, rpoS, rcsA, sdiA) in Salmonella isolates from ducks, highlighting their role in antimicrobial resistance and virulence.
Novel insights into antimicrobial-resistant, virulent and biofilm-forming Salmonella: Molecular and phenotypic evidence from duck at the human-animal-environment interface.
The study identifies multiple ESBL genes (bla TEM, bla SHV, bla CTX-M, bla AmpC) and biofilm-related genes (csgA, rpoS, rcsA, sdiA) in Salmonella isolates from ducks, highlighting their role in antimicrobial resistance and virulence.
SHV-7, a novel cefotaxime-hydrolyzing beta-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patients.
The study identifies SHV-7, a novel cefotaxime-hydrolyzing beta-lactamase, in Escherichia coli isolates from nursing home patients.
SHV-7, a novel cefotaxime-hydrolyzing beta-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patients.
SHV-7, a novel cefotaxime-hydrolyzing beta-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patients.
SHV-7, a novel cefotaxime-hydrolyzing beta-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patients.
SHV-7, a novel cefotaxime-hydrolyzing beta-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patients.
Characterization of a novel SHV beta-lactamase variant that resembles the SHV-5 enzyme.
Characterization of a novel SHV beta-lactamase variant that resembles the SHV-5 enzyme.
Characterization of a novel SHV beta-lactamase variant that resembles the SHV-5 enzyme.
Characterization of a novel SHV beta-lactamase variant that resembles the SHV-5 enzyme.
Evolution of extended-spectrum beta-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia.
The study identifies the emergence of a novel blaSHV-8 gene in Escherichia coli, which confers resistance to ceftazidime, other cephalosporins, and the monobactam aztreonam through an Asp-to-Asn substitution at amino acid position 179.
Evolution of extended-spectrum beta-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia.
Evolution of extended-spectrum beta-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia.
Evolution of extended-spectrum beta-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia.
Evolution of extended-spectrum beta-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia.
Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12.
Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12.
Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12.
Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12.
Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12.
Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12.
Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12.
Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12.
Nosocomial outbreak of Klebsiella pneumoniae producing SHV-5 extended-spectrum beta-lactamase, originating from a contaminated ultrasonography coupling gel.
The study identifies SHV-5 and TEM-1 beta-lactamases as the primary resistance mechanisms in a nosocomial outbreak of ceftazidime-resistant Klebsiella pneumoniae, highlighting the role of contaminated ultrasonography coupling gel as a transmission source.
beta-Lactamases Responsible for Resistance to Expanded-Spectrum Cephalosporins in Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis Isolates Recovered in South Africa.
The study identifies TEM-26, SHV-2, SHV-5, and an AmpC beta-lactamase as the primary extended-spectrum beta-lactamases responsible for resistance to expanded-spectrum cephalosporins in K. pneumoniae, E. coli, and P. mirabilis isolates from South Africa.
beta-Lactamases Responsible for Resistance to Expanded-Spectrum Cephalosporins in Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis Isolates Recovered in South Africa.
The study identifies TEM-26, SHV-2, SHV-5, and an AmpC beta-lactamase as the primary extended-spectrum beta-lactamases responsible for resistance to expanded-spectrum cephalosporins in K. pneumoniae, E. coli, and P. mirabilis isolates from South Africa.
Outbreak of ceftazidime-resistant Klebsiella pneumoniae in a pediatric hospital in Warsaw, Poland: clonal spread of the TEM-47 extended-spectrum beta-lactamase (ESBL)-producing strain and transfer of a plasmid carrying the SHV-5-like ESBL-encoding gene.
The study identifies the TEM-47 and SHV-5 extended-spectrum beta-lactamases as the primary mechanisms of ceftazidime resistance in Klebsiella pneumoniae isolates from a pediatric hospital in Warsaw, Poland. These genes were found to be carried on plasmids and contributed to the clonal spread of resistant strains.
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