The study identified blaSPM-1 and blaIMP-16 genes as responsible for carbapenem resistance in Pseudomonas aeruginosa isolates, highlighting the role of clonal spread in the hospital setting.

The study identified blaSPM-1 and blaVIM-2 as the primary metallo-beta-lactamase genes responsible for imipenem resistance in Pseudomonas aeruginosa isolates, with blaSPM-1 being the most prevalent.

The study identified blaSPM-1 as a metallo-beta-lactamase gene contributing to carbapenem resistance in Pseudomonas aeruginosa isolates causing ventilator-associated pneumonia.

The study identified blaSPM and blaIMP genes encoding metallo-beta-lactamases in multidrug-resistant Pseudomonas aeruginosa isolates, contributing to carbapenem resistance.

The study identified blaSPM-1, blaGES-1, blaOXA-51, and blaOXA-23 genes in Acinetobacter baumannii isolates from Tehran hospitals, highlighting the emergence of carbapenem resistance due to these beta-lactamase genes.

The study identified the blaSPM-1 gene as a significant contributor to carbapenem resistance in Pseudomonas aeruginosa isolates from Recife, Brazil.

The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.

The study reports the detection of the blaSPM-1 gene in Pseudomonas aeruginosa isolates from hospital sewage in southern Brazil, indicating the presence of carbapenem resistance in environmental strains.

The study characterizes mutations in SPM-1 metallo-beta-lactamase that influence resistance to β-lactam antibiotics, particularly cephalosporins and carbapenems, in Pseudomonas aeruginosa.

The study evaluated phenotypic tests to predict the presence of metallo-β-lactamase (MBL) in Pseudomonas aeruginosa isolates, identifying blaSPM-1 and blaIMP-1 genes as responsible for carbapenem resistance.

The study identified several AMR genes including blaCTX, blaTEM, blaSPM, mecA, and vanA in pediatric oncologic patients with bloodstream infections, demonstrating the utility of real-time PCR for rapid detection of pathogens and resistance genes.

The study identifies several AMR genes including blaGES-1, blaKPC-2, blaSPM-1, aac(6')-Ib, ant(2')-Ia, aph(3')-VIa, rmtD, catB3, arr-4, qacED1, sul1, and intI1, as well as mutations in the oprD gene contributing to carbapenem resistance in multidrug-resistant P. aeruginosa isolates from Recife, Brazil.

The study reviews the dissemination of carbapenemase-producing Gram-negative bacteria in the Middle East, highlighting the prevalence of KPC, VIM, IMP, NDM, and OXA-48 enzymes in various bacterial species such as Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa.

The study identified the presence of aac(6')-Ib-cr, qnrS1, and blaSPM genes in multidrug-resistant P. aeruginosa isolates in Brazil, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.

The study identified the presence of mecA, vanA, blaCTX, and blaSPM genes in various pathogens associated with bloodstream infections in paediatric cancer patients, highlighting the significance of molecular detection for rapid and accurate identification of antimicrobial resistance.

The study identifies the blaSPM-1 gene as a key factor in carbapenem resistance in Pseudomonas aeruginosa ST277 isolates, along with other resistance genes in genomic islands.

The study developed and evaluated the REBA-EAC assay for the rapid detection of clinically relevant antibiotic resistance genes in blood cultures positive for Gram-negative bacteria. The assay successfully identified various beta-lactamase genes, including ESBLs (CTX-M, TEM, SHV), AmpC beta-lactamases (DHA, CMY-2-like, ACT), and carbapenemases (IMP, VIM, NDM, KPC, OXA-48-like, SPM).

The study identifies the first case of São Paulo metallo-beta-lactamase-1 (SPM-1)-producing Pseudomonas aeruginosa in the Central-West region of Brazil, highlighting the emergence of this resistant strain and the importance of infection control measures.

The study identifies blaSPM-1 and blaVIM genes as key contributors to carbapenem resistance in Pseudomonas aeruginosa isolates, along with intrinsic resistance mechanisms such as overproduction of AmpC, loss of OprD porin, and overexpression of efflux pumps.

The study characterizes various carbapenemase genes, including blaVIM, blaIMP, blaKPC, blaNDM, blaSPM, blaOXA-23, blaOXA-24/40, blaOXA-58, blaOXA-72, and blaOXA-237, which confer resistance to carbapenems in Pseudomonas aeruginosa and Acinetobacter baumannii.

The study characterizes the broad-spectrum metallo-beta-lactamase SPM-1 and its chimeric variant SPM-1/Sfh-I, demonstrating that the sequence insertion in SPM-1 influences substrate selectivity and resistance profiles.

The study identified bla VIM-1, bla IMP-1, and bla SPM-1 genes as the primary metallo-beta-lactamase-encoding genes in Pseudomonas aeruginosa isolates from burn patients in Tehran, Iran.

The study identifies blaNDM-1, blaVIM-2, and blaSPM-1 as metallo-beta-lactamase genes that confer resistance to carbapenems. The expression of these genes in different bacterial hosts leads to varying fitness costs, influencing their dissemination and host specificity.

The study identified bla VIM, bla IMP, bla SPM, bla SIM, and bla NDM genes in MBL-producing P. aeruginosa isolates from diabetic foot infections in Iraq.

The study evaluated the EDTA-modified carbapenem inactivation method (eCIM) for detecting metallo-β-lactamase-producing Pseudomonas aeruginosa. It found that eCIM effectively identified VIM, NDM, and GES-producing isolates, but failed to detect IMP and SPM-producing isolates. Modifications to the mCIM improved detection of GES-producing isolates.

The study detected carbapenem-resistant genes bla OXA-48, bla SPM, and bla KPC in Escherichia coli isolates from drinking water in Khartoum, Sudan. bla OXA-48 was the most prevalent gene, followed by bla SPM and bla KPC. The isolates showed high resistance to tetracycline, gentamicin, ciprofloxacin, ceftriaxone, and chloramphenicol.

The study characterizes the multidrug-resistant Pseudomonas aeruginosa isolate CCBH4851, identifying several AMR genes including blaSPM-1, sul1, rmtD, blaOXA-56, aac(6')-I, aadA7, cmx, and bcr, as well as mutations in oprD and mexZ contributing to resistance.

The study identified the presence of beta-lactamase-encoding genes, including bla CTX-M1, bla SPM-1, bla OXA-2, and bla OXA-10, which confer resistance to carbapenems and cephalosporins. Additionally, it highlighted the high prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) P. aeruginosa isolates in the Brazilian Amazon region.

The study identified multiple AMR genes including IMP, VIM, OPR, SIM, SPM, GIM, NDM, VEB, PER, KPC, OXA, intI, intII, intIII, SHV, TEM, and CTXM in extensively drug-resistant Pseudomonas aeruginosa isolates. These genes conferred resistance to various antibiotics, particularly carbapenems and beta-lactams.

The Xpert Carba-R NxG assay effectively detects various carbapenemase genes, including blaVIM, blaIMP, blaNDM, blaSPM, blaKPC, and blaGES, in Pseudomonas aeruginosa isolates.

This review discusses the role of metallo-beta-lactamases (MBLs) in multidrug resistance, focusing on their structure, mechanism, and contribution to resistance against β-lactam antibiotics. It highlights the importance of MBLs in the spread of resistance and the challenges they pose for inhibitor design.

The study identified blaNDM, blaVIM, blaSPM, blaIMP, and blaGIM carbapenem resistance genes in carbapenem-resistant Gram-negative bacilli from patients with ventilator-associated pneumonia, with blaNDM being the most prevalent.

The study developed and optimized a high-resolution melting curve analysis (HRMA) assay for detecting New Delhi metallo-beta-lactamase (NDM)-producing Pseudomonas aeruginosa. The HRMA method demonstrated high analytical sensitivity and specificity for identifying NDM and MBL genes in P. aeruginosa strains.

The study evaluated the performance of phenotypic tests (Carba NP, Blue Carba, and mCIM/eCIM) for detecting carbapenemase-producing Pseudomonas spp. in Brazil. It identified several carbapenemase genes, including bla VIM-2, bla SPM-1, bla IMP-10, bla VIM-24, bla NDM-1, and bla KPC-2, in clinical isolates.

The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.

The study identified a diverse array of antibiotic resistance genes (ARG) in the horse gut microbiome, highlighting the widespread use of antibiotics in horse management. The resistome characteristics were analyzed alongside the identification of microbes associated with athletic performance.

The study identifies multiple AMR genes and mutations contributing to CZA resistance in Enterobacterales and P. aeruginosa, including MBLs, blaKPC, blaVIM, blaIMP, blaNDM, blaSPM-1, and various mutations in genes related to efflux pumps, porins, and beta-lactamases.

The study identifies the blaSPM-1 gene as a key determinant of carbapenem resistance in Pseudomonas aeruginosa isolates in northern Brazil, highlighting the role of the high-risk clone ST277 in the spread of these resistant strains.

The study evaluates the impact of various beta-lactamases on the susceptibility of Escherichia coli to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and their combinations with beta-lactamase inhibitors avibactam and taniborbactam.

The study identified several β-lactamase genes, including bla CMY, bla MOX, bla FOX, bla EBC, bla DHA, bla CTX-M1, bla SHV, bla TEM, bla VIM, bla IMP, bla SPM, bla SIM, and bla GIM, in Enterobacteriaceae isolates from milk samples in India, highlighting the presence of multidrug-resistant bacteria in the dairy value chain.

The study identified bla GES-2, bla OXA48-like, bla NDM, bla SPM, and bla VIM as the main carbapenemase genes in MDR P. aeruginosa isolates. Overexpression of mex efflux pumps, particularly mex C, was strongly associated with multidrug resistance.

Xeruborbactam (XER) showed superior in vitro potency against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales when combined with various β-lactam antibiotics compared to other β-lactam/β-lactamase inhibitor combinations. XER effectively inhibited a wide range of β-lactamases, including metallo-β-lactamases (MBLs) and serine β-lactamases, enhancing the activity of antibiotics such as meropenem, cefepime, ceftolozane, ceftriaxone, aztreonam, piperacillin, and ertapenem.

The study evaluated the gene expressions of Metallo-beta-lactamase genes GIM, VIM, and SPM in Pseudomonas aeruginosa clinical isolates, highlighting their role in carbapenem resistance.

The study evaluates the inhibitory activity of taniborbactam against various metallo-beta-lactamases (MBLs), demonstrating that it effectively inhibits most NDM- and VIM-like enzymes but not SIM-1. Specific mutations in VIM-1 and NDM-1 were found to confer resistance to taniborbactam.

The study developed a novel microarray technique using photoactivated 96-well plates to identify and quantify beta-lactamase genes and their RNA transcripts. The method successfully detected various beta-lactamase genes, including ESBLs, inhibitor-resistant beta-lactamases, and carbapenemases, demonstrating high specificity and reproducibility.

The study identified various beta-lactamase genes, including blaSPM, blaKPC, blaSHV, blaCTX-M, blaOXA, blaTEM, blaPER, blaVIM, and blaVIM-2 in Pseudomonas aeruginosa, and blaCTX-M, blaTEM, blaKPC, blaNDM, and blaOXA in Klebsiella pneumoniae. Additionally, aac(3)-IV, aadA1, aac(3)-II, sul2, sul1, sul3, dfrA, cmlA, and tetA were found to confer resistance to aminoglycosides, sulfonamides, trimethoprim, chloramphenicol, and tetracyclines.

The study identified various carbapenemase-encoding genes, including bla KPC -like, bla NDM -like, bla OXA-23 -like, bla OXA-58 -like, bla OXA-143 -like, bla OXA-48 -like, bla SPM -like, bla VIM -like, and bla IMP -like, in carbapenem-resistant bacteria from Rondônia, Brazil.

The study identifies and characterizes beta-lactamase homologous proteins in gram-negative bacteria of the ESKAPEE group, highlighting their potential role in resistance to beta-lactam antibiotics.

Cefepime-taniborbactam showed potent in vitro activity against Enterobacterales and P. aeruginosa, particularly effective against isolates with carbapenemase genes such as blaIMP, blaNDM, and blaVIM, as well as those with mutations in ftsI, ompK35, and ompK36.

The study identified several beta-lactamase genes, including bla KPC-2, bla CTX-M variants, and bla NDM-1, which confer resistance to carbapenems and cephalosporins in Gram-negative bacilli in Brazil. These genes were detected in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa isolates.

The study identifies that meso-dimercaptosuccinic acid (DMSA) enhances the efficacy of ceftazidime (CAZ) and cefepime (FEP) against IMP-producing Pseudomonas aeruginosa by inhibiting IMP metallo-β-lactamase variants, demonstrating significant synergistic effects.

The study identifies bla VIM, bla IMP, and bla NDM as the most commonly detected MBL genes in Acinetobacter clinical isolates globally, with high resistance rates to carbapenems, cephalosporins, and fluoroquinolones.

Xeruborbactam in combination with meropenem shows potent activity against carbapenemase-producing Enterobacterales, including strains resistant to other β-lactam/beta-lactamase inhibitor combinations. Specific beta-lactamases like blaIMP-23 and blaSPM-1 were identified as resistant to xeruborbactam.

The study identified various antibiotic resistance genes in bacterial isolates from white stork cloaca and environmental samples, highlighting the presence of resistance mechanisms against beta-lactams, aminoglycosides, quinolones, and polymyxins.

The study identified multiple carbapenemases, extended-spectrum beta-lactamases, and 16S rRNA methyltransferases in multidrug-resistant Pseudomonas aeruginosa isolates from Bolivia, highlighting the prevalence of high-risk clones and resistance mechanisms.

The study identified several AMR genes, including bla_KPC, bla_NDM, bla_OXA-48, bla_SPM, bla_VIM, bla_TEM, bla_SHV, bla_CTX-M, and mcr-1, in bacterial isolates from animal-origin meat samples. These genes conferred resistance to various antibiotics, including carbapenems, beta-lactams, and polymyxins.

The study identifies NDM-1 and NDM-5 as metallo-beta-lactamases that confer resistance to carbapenems in Acinetobacter baumannii. It also shows that the stability of NDM-1 is influenced by host-specific proteases CtpA and DegP.