blaSed-1

β-lactamase

Overview

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
P167Q	-	-	Citrobacter sedlakii, Escherichia coli	ceftazidime	Reslit	Candidate
D179G	-	-	Citrobacter sedlakii, Escherichia coli	ceftazidime	Reslit	Candidate

Papers1

Unique Regulation of Sed-1 β-Lactamase in Citrobacter sedlakii: Insights on Resistance to Third-Generation Cephalosporin.

Mutations in bla_Sed-1 contribute to extended-spectrum β-lactamase characteristics.

Protein Change: P167Q, D179G
Organisms: Citrobacter sedlakii, Escherichia coli
Confers Resistance To: ceftazidime
Validation Method: cloning into E. coli ML4947 and comparison with wild-type transformant pCR2807/ML4947
Source Database: Reslit