Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
class A beta-lactamase TEM-104
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| M69L | - | - | Escherichia coli | penicillin | Reslit | Candidate |
| R275Q | - | - | Escherichia coli | penicillin | Reslit | Candidate |
| R164S | - | - | Escherichia coli | ceftazidime | Reslit | Candidate |
| S164F | - | - | E. coli, Shigella spp. | ampicillin|penicillin | Reslit | Candidate |
| E166Y | - | - | E. coli | ampicillin | Reslit | Candidate |
| Y166E | - | - | E. coli | ampicillin | Reslit | Candidate |
| S170N | - | - | E. coli | ampicillin | Reslit | Candidate |
| I68M | - | - | E. coli | ampicillin | Reslit | Candidate |
| M182T | - | - | Neisseria gonorrhoeae | penicillin|cephalosporins | Reslit | Candidate |
| G238S | - | - | Neisseria gonorrhoeae | penicillin|cephalosporins | Reslit | Candidate |
| R500W | - | - | Escherichia coli | ampicillin|amoxicillin clavulanic acid|ceftazidime | Reslit | Candidate |
| R105W | - | - | Escherichia coli | beta lactams | Reslit | Candidate |
| C-32T | - | blaTEM promoter region | Escherichia coli | amoxicillin clavulanic acid|piperacillin tazobactam|ticarcillin clavulanic acid | Reference Gene Catalog | Candidate |
| C-141G | - | blaTEM promoter region | Escherichia coli | amoxicillin clavulanic acid|piperacillin tazobactam|ticarcillin clavulanic acid | Reference Gene Catalog | Candidate |
| G-162T | - | blaTEM promoter region | Escherichia coli | amoxicillin clavulanic acid|piperacillin tazobactam|ticarcillin clavulanic acid | Reference Gene Catalog | Candidate |
| - | - | Escherichia coli | amoxicillin clavulanic acid | Reslit | Candidate | |
| - | - | Escherichia coli | amoxicillin clavulanic acid | Reslit | Candidate | |
| - | - | Escherichia coli | amoxicillin clavulanic acid | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaTEM-104 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | BETA-LACTAM, UNKNOWN BETA-LACTAM +10 | Klebsiella pneumoniae +1 | Iran, Northern Kenya, Sub-Saharan Africa, Bangladesh, Djibouti | 2016, 2023, 2025 | AF516719.1 | AAM61952.1 |
| blaTEM-123 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Proteus mirabilis | - | - | AY327539.1 | AAQ93490.1 |
| blaTEM-124 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Morganella morganii | - | - | AY327540.1 | AAQ93491.1 |
| blaTEM-142 | Card DatabaseReference Gene CatalogResFinder Database | 4 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Escherichia coli | - | - | DQ388882.1 | ABD60314.1 |
| blaTEM-143 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Escherichia coli | - | - | DQ075245.1 | AAY85632.1 |
| blaTEM-145 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, AMOXICILLIN +7 | Escherichia coli | - | - | DQ105528.2 | AAZ14083.2 |
| blaTEM-146 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Escherichia coli | - | - | DQ105529.2 | AAZ14084.2 |
| blaTEM-147 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Pseudomonas aeruginosa | - | - | DQ279850.1 | ABB84515.1 |
| blaTEM-148 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | BETA-LACTAM, UNKNOWN BETA-LACTAM +3 | Escherichia coli | Peru | 2020, 2022 | AM087454.1 | CAJ32372.1 |
| blaTEM-150 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | BETA-LACTAM, UNKNOWN BETA-LACTAM +3 | Escherichia coli +1 | Spain|porcine, Vietnam | 2020, 2022 | AM183304.1 | CAJ66089.1 |
| blaTEM-156 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Proteus mirabilis | - | - | AM941159.1 | CAQ00120.1 |
| blaTEM-162 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Acinetobacter haemolyticus | - | - | EF468463.1 | ABO64442.1 |
| blaTEM-166 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Escherichia coli | - | - | FJ197316.1 | ACI25375.1 |
| blaTEM-189 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Escherichia coli | - | - | JN254627.1 | AEL79515.1 |
| blaTEM-190 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | BETA-LACTAM, UNKNOWN BETA-LACTAM +9 | Escherichia coli +1 | India, Spain, Switzerland, Ghana, Kathmandu, Nepal, Sub-Saharan Africa, Egypt | 2013, 2020, 2023, 2024, 2025 | JN416112.1 | AEL88240.1 |
| blaTEM-193 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +1 | Acinetobacter baumannii +1 | - | 2025 | JN935135.1 | AFC75523.1 |
| blaTEM-194 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | BETA-LACTAM, UNKNOWN BETA-LACTAM +5 | Acinetobacter baumannii +3 | China, Algeria | 2023, 2024 | JN935136.1 | AFC75524.1 |
| blaTEM-196 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Shigella sonnei | - | - | JQ034306.1 | AFE48832.1 |
| blaTEM-197 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Klebsiella pneumoniae | - | - | HQ877606.1 | AEK48085.1 |
| blaTEM-198 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +1 | Klebsiella pneumoniae +1 | China | 2025 | AB700703.1 | BAL68178.1 |
| blaTEM-205 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +2 | Pseudomonas aeruginosa +1 | Norway | 2023 | KC900516.1 | AGZ20205.1 |
| blaTEM-206 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | TICARCILLIN, CEPHALOTHIN +10 | Escherichia coli +2 | Italy, Caribbean, Hong Kong|mainland China|Australia|Canada|United States of America|South Africa|Taiwan|United Kingdom | 2018, 2021, 2025 | KC783461.1 | AGK82336.1 |
| blaTEM-207 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | AZTREONAM, TICARCILLIN +11 | Escherichia coli +1 | - | 2024 | KC818234.1 | AGK40892.1 |
| blaTEM-208 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Escherichia coli | - | - | KC865667.1 | AGL39384.1 |
| blaTEM-209 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +1 | Klebsiella pneumoniae +1 | Hong Kong|mainland China|Australia|Canada|United States of America|South Africa|Taiwan|United Kingdom | 2025 | KF240808.1 | AGW25367.1 |
| blaTEM-211 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Proteus mirabilis | - | - | KF513179.1 | AHA80960.1 |
| blaTEM-212 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | BETA-LACTAM, UNKNOWN BETA-LACTAM +2 | Providencia stuartii +1 | Europe | 2016 | KF481968.1 | AHA49909.1 |
| blaTEM-214 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | BETA-LACTAM, UNKNOWN BETA-LACTAM +6 | Escherichia coli +4 | Ontario, Canada, Hong Kong|mainland China|Australia|Canada|United States of America|South Africa|Taiwan|United Kingdom, Djibouti, United Arab Emirates | 2022, 2025 | KP050491.1 | AJO16044.1 |
| blaTEM-215 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | BETA-LACTAM, UNKNOWN BETA-LACTAM +4 | Escherichia coli +1 | Taipei, Taiwan, Hangzhou, China, Thailand, United Arab Emirates | 2020, 2021, 2025 | KP050492.1 | AJO16045.1 |
| blaTEM-216 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +1 | Escherichia coli +1 | Hong Kong|mainland China|Australia|Canada|United States of America|South Africa|Taiwan|United Kingdom | 2025 | KF944358.1 | AHJ78622.1 |
| blaTEM-217 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Enterobacter cloacae | - | - | HG934763.1 | CDN33426.1 |
| blaTEM-219 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +1 | Escherichia coli | - | 2020 | KM114268.1 | AIS39742.1 |
| blaTEM-224 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | KU664545.1 | AMD11804.1 |
| blaTEM-225 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Escherichia coli | - | - | KY432403.1 | APT67991.1 |
| blaTEM-226 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Escherichia coli | - | - | KY646301.1 | AQT03459.1 |
| blaTEM-227 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Escherichia coli | - | - | KY418040.1 | AQX83499.1 |
| blaTEM-228 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Neisseria gonorrhoeae | - | - | KY851075.1 | ARF19528.1 |
| blaTEM-229 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Acinetobacter haemolyticus | - | - | MG821356.1 | AUS83547.1 |
| blaTEM-230 | Card DatabaseReference Gene CatalogResFinder Database | 5 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Escherichia coli | - | - | MG821377.1 | AUT06962.1 |
| blaTEM-231 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Escherichia coli | - | - | MG821378.1 | AUT06963.1 |
| blaTEM-232 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Klebsiella pneumoniae | - | - | MH079593.1 | AVP73880.1 |
| blaTEM-233 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | BETA-LACTAM, UNKNOWN BETA-LACTAM +2 | Escherichia coli | Texas, USA | 2019 | MH270416.1 | AWH90786.1 |
| blaTEM-234 | Card DatabaseReference Gene CatalogResFinder Database | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Pseudomonas aeruginosa | - | - | MH243353.1 | AWI33307.1 |
| blaTEM-236 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Escherichia coli | - | - | MH133325.1 | AXL10707.1 |
| blaTEM-237 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Escherichia coli | - | - | MG860488.1 | AVX49110.1 |
| blaTEM-238 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Escherichia coli | - | - | MK125014.1 | AYR04769.1 |
| blaTEM-239 | Card DatabaseReference Gene CatalogReslit | 3 | BETA-LACTAM, penicillin | Neisseria gonorrhoeae | Kenya | 2020 | MK497256.1 | QBC36181.1 |
| blaTEM-240 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella variicola | - | - | MK529911.1 | QBG79064.1 |
| blaTEM-241 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Pseudomonas aeruginosa | - | - | MN065797.1 | QDC28520.1 |
| blaTEM-242 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Providencia stuartii | - | - | MN219693.1 | QDY98370.1 |
| blaTEM-243 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Escherichia coli | - | - | MW261527.1 | QPG87090.1 |
| blaTEM-245 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Neisseria gonorrhoeae | - | - | OM617737.1 | ULU82600.1 |
| blaTEM-246 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Neisseria gonorrhoeae | - | - | OM617738.1 | ULU82601.1 |
| blaTEM-247 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Pseudomonas alloputida | - | - | ON651488.1 | UTS94241.1 |
| blaTEM-248 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Escherichia coli | - | - | OP142511.1 | UUT29265.1 |
| blaTEM-249 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Escherichia coli | - | - | OP142512.1 | UUT29266.1 |
| blaTEM-250 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella oxytoca | - | - | OQ592371.1 | WEG44935.1 |
| blaTEM-251 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Escherichia coli | - | - | OQ870701.1 | WGO19551.1 |
| blaTEM-252 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Escherichia coli | - | - | PP933208.1 | XCA96001.1 |
| blaTEM-253 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Escherichia coli | - | - | PQ037599.1 | XDB68957.1 |
| blaTEM-254 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Escherichia coli | - | - | PQ037600.1 | XDB68958.1 |
| blaTEM-255 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | - | PQ284151.1 | XGD00489.1 |
| blaTEM-256 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | - | PQ284152.1 | XGD00490.1 |
| blaTEM-257 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Klebsiella pneumoniae | - | - | PQ284153.1 | XGD00491.1 |
| blaTEM-258 | Card DatabaseReference Gene CatalogReslit | 3 | BETA-LACTAM, ampicillin +1 | Enterobacter cloacae subsp. cloacae +1 | Uruguay | 2024 | PQ362078.1 | XHJ89682.1 |
| blaTEM-259 | Reference Gene Catalog | 1 | BETA-LACTAM | Klebsiella pneumoniae | - | - | PV075185.1 | XOU30649.1 |
| blaTEM-260 | Reference Gene Catalog | 1 | BETA-LACTAM | Escherichia coli | - | - | PV075188.1 | XOU30652.1 |
| blaTEM-261 | Reference Gene Catalog | 1 | BETA-LACTAM | Providencia stuartii | - | - | PV075189.1 | XOU30653.1 |
| blaTEM-262 | Reference Gene Catalog | 1 | BETA-LACTAM | Providencia stuartii | - | - | PV075190.1 | XOU30654.1 |
| blaTEM-264 | Reference Gene Catalog | 1 | BETA-LACTAM | Escherichia coli | - | - | JBJJAU010000011.1 | MFL1401494.1 |
| blaTEM-265 | Reference Gene Catalog | 1 | BETA-LACTAM | Escherichia coli | - | - | PX115215.1 | XZC91439.1 |
| blaTEM-266 | Reference Gene Catalog | 1 | BETA-LACTAM | Escherichia coli | - | - | PX115216.1 | XZC91440.1 |
| blaTEM-267 | Reference Gene Catalog | 1 | BETA-LACTAM | Escherichia coli | - | - | PX115217.1 | XZC91441.1 |
| blaTEM-268 | Reference Gene Catalog | 1 | BETA-LACTAM | Escherichia coli | - | - | PX115218.1 | XZC91442.1 |
| blaTEM-269 | Reference Gene Catalog | 1 | BETA-LACTAM | Escherichia coli | - | - | PX115219.1 | XZC91443.1 |
| blaTEM-270 | Reference Gene Catalog | 1 | BETA-LACTAM | Escherichia coli | - | - | PX115220.1 | XZC91444.1 |
| blaTEM-271 | Reference Gene Catalog | 1 | BETA-LACTAM | Escherichia coli | - | - | PX115223.1 | XZC91447.1 |
| blaTEM-272 | Reference Gene Catalog | 1 | BETA-LACTAM | Escherichia coli | - | - | PX115224.1 | XZC91448.1 |
| blaTEM-55 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOTHIN +4 | Escherichia coli | - | - | DQ286729.1 | ABB97007.1 |
| blaTEM-97 | Reference Gene CatalogResFinder Database | 3 | TICARCILLIN, AMOXICILLIN +7 | Escherichia coli | - | - | AF397067.1 | AAK85244.1 |
| blaTEM-98 | Card DatabaseReference Gene CatalogResFinder Database | 5 | TICARCILLIN, CEPHALOTHIN +4 | Escherichia coli | - | - | AF397068.1 | AAK85245.1 |
| blaTEM-99 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, AMOXICILLIN +9 | Escherichia coli | United Arab Emirates | 2025 | AF397066.1 | AAK85243.1 |
| blaTEM-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 561 | ampicillin, amoxicillin +31 | Salmonella enterica subsp. enterica serovar Typhi str. CT18 +165 | Tanzania, France, Taiwan, Spain, Greece, South Korea, Vietnam, Italy, Europe, Korea, Turkey, Toronto, Canada|Vancouver, Canada|India, Tel Aviv, Israel, Oklahoma, Central African Republic, Poland, Japan, Russia, Africa, Eastern Europe|India|Latin America|Asia Pacific|North America|Western Europe, Burkina Faso, United States, Germany, China, Italy|Denmark|United Kingdom, India, USA|Greece|Sweden|Colombia|Brazil|Israel, Japan|United States, Belgium, Canada, Switzerland, Australia, Asia|Africa|Europe|South America|Global, Global, Europe|Asia|North America|South America, Denmark, Madagascar, UK, United States|U.S.|France|Korea, Arabian Peninsula|Saudi Arabia|United Arab Emirates|Kuwait|Oman|Qatar|Bahrain, Iran, Brazil, United Kingdom, Austria|Europe, Saudi Arabia, Nepal, Western Pennsylvania, Guatemala|Spain, Zambia, Argentina, Ankara, Turkey, Austria, Algeria, Kenya, Netherlands, Republic of Korea|Vietnam, Nigeria, Pakistan, United States|Guatemala|India|Jordan|Lebanon|France|Poland|Romania|Russia, Southern Africa, Mali, Malaysia, Northern Tanzania, Sweden, Southcentral Alaska, Ethiopia, Norway, Guangzhou, China|Guangzhou, San Francisco|Seattle|Minnesota|Minneapolis|Sacramento|Dallas|Jackson, Europe|Switzerland|Canada, Shandong Province, China, England, Maanshan Anhui Province, China, SouthWest Nigeria, Shanghai, China, Egypt, Uganda, Delhi|India, Antarctic Peninsula, Xinjiang, China, United States|Italy|Bangladesh, global, India|United States, Global|global, Northwest China, International Space Station, La Paz, Bolivia|La Paz River basin, Malawi, Denmark|France|Poland|Italy|Hungary|Germany|Estonia|United States, Egypt|Africa|Europe|Asia|Middle East|Indonesia|India|USA, Eastern China, South Africa, Chongqing|China, Colombia, Poland|eastern Poland, Marseille, France, Paraná, Brazil, Ghana, Bangladesh, Brazil|Santa Catarina|Minas Gerais|Paraná|São Paulo|Rio de Janeiro|Rio Grande do Sul, Belo Horizonte, Brazil, Kewaunee County, Wisconsin, Czech Republic, China|USA|Italy|Israel, Europe|EU/EEA|China|Spain|USA|Denmark|Sweden|Belgium|Switzerland|Norway|Netherlands|Slovakia|Germany|Romania|Italy|Cyprus, Yunnan Province, USA|Canada, Kashmir valley, India, Europe|Poland, Denmark|Finland|Iceland|Lithuania|Netherlands|Spain, North America|turtle, Armenia|Georgia, Europe|Canada, Germany|Lower Saxony|North-Rhine-Westphalia, Middle East|South Asia, Abuja, Nigeria, Norway|India, Europe|Poland|USA|China|France, Sri Lanka, California|Europe|North America|Republic of Congo, Serbia, Northeast China, Slovakia, Thailand, Europe|China|Egypt|Vietnam|Colombia, Portugal, Cambodia, Jiangsu, China|China, New Zealand, North Carolina|USA, Hangzhou, China, Victoria, Australia, Benin, Finland|Eastern Finland, Mexico, Hong Kong, Europe|South Korea, Bangkok, Thailand, Kuwait, North America|Europe|Asia|Oceania|South America, Romania, Guizhou Province, China, Europe|Portugal, North America|Asia|Europe|Middle East|Africa, Michigan, USA|Maryland, USA|USA, Zhejiang Province, China, Philippines, Southwest Nigeria, Democratic Republic of Congo|Democratic Republic of the Congo, Romania|Cluj County, North Western Romania, Tunisia, Portugal|Spain, Egypt|United States|China, Bulgaria, Gulf Cooperation Council (GCC) region|Gulf Cooperation Council region, Northern China, Denmark|China|Japan|United States|Spain|Portugal|Thailand|UK, Central Panama, Andaman and Nicobar Islands, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, South-West Nigeria, Northern Kenya, Northwest Tuscany, Central Italy, Faisalabad, Pakistan, Asia|Europe|Africa|Americas|America, Chile, Taiyuan City, Shanxi Province, China, Czech Republic|location A|location B|location C, Spain|Asturias, Spain, Wales|Nigeria, Southern Asia|Eastern Africa|South-eastern Asia|Western Africa|Americas|India|Bangladesh|Pakistan|Nepal|Kenya|Nigeria|South Africa|Chile|Mexico, Mexico|Mexico City, Australia|South Australia, Oman, Brazilian Amazon Region, Tennessee, USA|East Tennessee, Germany|Australia|Taiwan|USA|Canada|Denmark, Lahore, Pakistan, Quebec, Canada, USA|China|India|Thailand|Brazil|Hungary|South Africa|Egypt|Tunisia|Europe|Asia, Oxfordshire, UK, Bangladesh|India|China|France|Brazil, Istanbul, Türkiye|Istanbul, Turkey, Nile Delta region of Egypt, Accra, Ghana|Ghana, Southeastern United States, Inner Mongolian, United States|Pakistan|Bangladesh|Nigeria|Iraq|India, China|North America|Asia|Europe|Oceania|South America|Africa|Global|West China, Oregon, USA|Oregon, Europe|Thailand|Sweden|Norway|UK, Bulgaria|Europe, Rwanda, Fujian Province, Southeast China|China, Israel|Texas, Southeast Asia, Guangdong, China, northern China, Qatar, Ankara, Guizhou province, China|Guizhou, China, Kathmandu, Nepal, New Mexico, USA, Lebanon, Shanghai|Minhang District, Sub-Saharan Africa, USA, China|Spain, Quebec|Shenzhen Bay, China|North America|Asia|Europe|Africa|Other, Northern Nigeria|Nigeria, New York City, Africa|Cameroon, Europe|Turkey, North America|Asia|Europe, Southern China, Hawaii|Washington|Southern Texas, West Bengal, India | 1965, 1995, 1997, 1998, 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AL513383.1 | CAD09800.1 |
| blaTEM-117 | Card DatabaseReslit | 2 | beta lactams | Escherichia coli | - | 2025 | AY130282.1 | AAN05026.1 |
| blaTEM-118 | Card Database | 1 | - | Klebsiella oxytoca | - | - | AY130285.1 | AAN05029.1 |
| blaTEM-169 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | AZTREONAM, TICARCILLIN +14 | Salmonella enterica subsp. enterica serovar Infantis +2 | India, Sub-Saharan Africa | 2010, 2013, 2025 | FJ873740.1 | ACP18864.1 |
| blaTEM-181 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | BETA-LACTAM, UNKNOWN BETA-LACTAM +7 | Escherichia sp. Sflu5 +4 | Thailand|Nepal, Kenya, Peru, United Kingdom | 2011, 2020, 2022, 2023 | AM743197.2 | WP_000027060.1 |
| blaTEM-192 | Card Database | 1 | - | Klebsiella pneumoniae | - | - | JF949915.1 | AEQ59620.1 |
| blaTEM-199 | Card Database | 1 | - | Proteus mirabilis | - | - | JX050178.1 | AFN69127.1 |
| blaTEM-2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 14 | amoxicillin, ticarcillin +15 | Pseudomonas aeruginosa +8 | France, Denmark|Taiwan|South Korea|Africa|Asia|Europe|North America|Canada|Norway|South Africa|United States, Belgium, Mexico|Mexico City, Sub-Saharan Africa, southwest England | 1976, 1982, 1991, 1995, 1999, 2000, 2015, 2020, 2021, 2023, 2025 | X54606.1 | CAA38429.1 |
| blaTEM-20 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | AZTREONAM, TICARCILLIN +15 | Klebsiella pneumoniae +4 | Republic of Korea, Japan, China | 1990, 1999, 2004, 2013, 2015, 2022, 2025 | Y17581.1 | CAA76793.1 |
| blaTEM-21 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 10 | AZTREONAM, TICARCILLIN +17 | Klebsiella pneumoniae +4 | France, global | 1990, 1999, 2003, 2005, 2018, 2023 | Y17582.1 | CAA76794.1 |
| blaTEM-210 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | BETA-LACTAM, UNKNOWN BETA-LACTAM +1 | Escherichia coli +1 | Hong Kong|mainland China|Australia|Canada|United States of America|South Africa|Taiwan|United Kingdom | 2014, 2025 | NG_050243.1 | WP_032072208.1 |
| blaTEM-213 | Card DatabaseReference Gene CatalogResFinder Database | 5 | AZTREONAM, TICARCILLIN +8 | Pseudomonas aeruginosa +1 | - | 2017 | KF663615.1 | AHA58207.1 |
| blaTEM-235 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | mixed culture bacterium PE_gF3SD01_32 | - | 2009 | NG_059898.1 | WP_110174956.1 |
| blaTEM-26 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | ceftazidime, aztreonam +12 | Enterobacter kobei +3 | South Africa | 1992, 1998 | NG_050256.1 | WP_047028173.1 |
| blaTEM-29 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | AZTREONAM, TICARCILLIN +11 | Escherichia coli +2 | Netherlands, Canada | 1995, 1999, 2001, 2004 | Y17584.1 | CAA76796.1 |
| blaTEM-31 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Klebsiella pneumoniae | - | 1992 | NG_068213.1 | WP_165539487.1 |
| blaTEM-32 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 10 | penicillin, amoxicillin clavulanic acid +15 | Shigella sonnei +2 | Poland, Madrid, Spain, Czech Republic, Finland, China | 1993, 2008, 2010, 2021, 2023, 2025 | NG_050261.1 | WP_052944427.1 |
| blaTEM-35 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | cefoxitin, cefotaxime +16 | Escherichia coli +1 | United Kingdom, southern Ontario, Canada, Switzerland, Accra, Ghana|Ghana, Somali region, Ethiopia|Somali Region, Ethiopia, Oman | 1994, 2006, 2015, 2022, 2024, 2025 | NG_050264.1 | WP_063864910.1 |
| blaTEM-36 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | amoxicillin clavulanic acid, TICARCILLIN +8 | Escherichia coli | Madrid, Spain | 1994, 2010 | NG_052650.1 | WP_075985685.1 |
| blaTEM-37 | Card DatabaseReference Gene CatalogReslit | 5 | penicillin, amoxicillin clavulanic acid +1 | Escherichia coli +1 | Poland, Madrid, Spain | 1995, 2008, 2010 | NG_068214.1 | WP_159373457.1 |
| blaTEM-39 | Card DatabaseReference Gene Catalog | 3 | BETA-LACTAM | Escherichia coli | - | 1995 | NG_065940.1 | WP_148044474.1 |
| blaTEM-42 | Card DatabaseReslit | 2 | ampicillin, piperacillin +1 | Pseudomonas aeruginosa +1 | Europe | 2017 | X98047.1 | CAA66659.1 |
| blaTEM-5 | Card DatabaseReference Gene CatalogReslit | 3 | ceftazidime, aztreonam +1 | Escherichia coli +1 | Europe | 1989, 2004 | NG_068215.1 | WP_109963600.1 |
| blaTEM-52 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 44 | cefoxitin, cefotaxime +21 | Klebsiella pneumoniae +17 | Korea, South Korea|Korea, Canada, French Guyana, Republic of Korea, Italy, Belgium|France, Porto, Portugal, France, Switzerland, Netherlands, Japan, Europe, Belgium, The Netherlands, Germany, global, China, Europe|EU|non-EU|non-Member State|China|Spain|USA|Finland|Germany|Norway|Switzerland|Netherlands, Europe|Spain|Hungary|Germany|France|Belgium|Poland|United Kingdom|Denmark, Europe|broiler production pyramid, Mexico|Mexico City, Kathmandu, Nepal|Nepal | 1998, 1999, 2001, 2002, 2003, 2004, 2005, 2007, 2010, 2011, 2012, 2013, 2014, 2015, 2017, 2018, 2019, 2020, 2021, 2023, 2025 | Y13612.1 | CAA73933.1 |
| blaTEM-59 | Card DatabaseReslit | 2 | penicillin | Klebsiella oxytoca +1 | - | 1999 | AF062386.1 | AAD45935.1 |
| blaTEM-7 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Escherichia coli | - | 1988 | AF527798.1 | AAO33760.1 |
| blaTEM-73 | Card DatabaseReslit | 2 | amoxicillin, ticarcillin +2 | Proteus mirabilis +1 | France | 1999 | AJ012256.1 | CAB65358.1 |
| blaTEM-75 | Card Database | 1 | - | Klebsiella pneumoniae | - | - | AY130284.1 | AAN05028.1 |
| blaTEM-89 | Card Database | 1 | - | Proteus mirabilis | - | - | AY039040.1 | AAK71474.1 |
| blaTEM-9 | Card DatabaseReference Gene CatalogResFinder Database | 5 | AZTREONAM, TICARCILLIN +8 | Escherichia coli | - | 1987 | NG_056168.1 | WP_102607453.1 |
| blaTEM-27 | Reslit | 2 | penicillin, cephalosporins +3 | Salmonella enteritidis +2 | Trinidad and Tobago, Spain | 1999, 2002 | - | - |
| blaTEM-22 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Klebsiella pneumoniae | - | 1993, 1999 | Y17583 | CAA76795.1 |
| blaTEM-3 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 12 | amoxicillin, ticarcillin +24 | Proteus mirabilis +5 | France, global, Egypt | 1987, 1992, 1999, 2000, 2003, 2018, 2023, 2024, 2026 | X64523 | CAA45828.1 |
| blaTEM-24 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 17 | amoxicillin, ticarcillin +21 | Proteus mirabilis +5 | France, Spain, Italy, global, Ghana, Europe|Asia|North America|Western and South-Eastern Asia, Mexico|Mexico City, USA|China|India|Thailand|Brazil|Hungary|South Africa|Egypt|Tunisia|Europe|Asia, Sub-Saharan Africa | 1989, 1999, 2001, 2002, 2006, 2008, 2010, 2014, 2015, 2018, 2019, 2023, 2024, 2025 | AF032125|AF032126 | CAA46345.1 |
| blaTEM-44 | Reslit | 1 | amoxicillin, ticarcillin +2 | Proteus mirabilis +1 | France | 1999 | - | - |
| blaTEM-57 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | amoxicillin, ticarcillin +12 | Proteus mirabilis +3 | France, Ethiopia, Hong Kong|mainland China|Australia|Canada|United States of America|South Africa|Taiwan|United Kingdom | 1999, 2009, 2017, 2025 | FJ405211.1 | ACJ43254.1 |
| blaTEM-66 | Reslit | 2 | amoxicillin, ticarcillin +8 | Proteus mirabilis +1 | France | 1999, 2000 | - | - |
| blaTEM-65 | Reslit | 1 | amoxicillin, ticarcillin +2 | Proteus mirabilis +1 | France | 1999 | - | - |
| blaTEM-74 | Reslit | 1 | amoxicillin, ticarcillin +2 | Proteus mirabilis +1 | France | 1999 | - | - |
| blaTEM-77 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, AMOXICILLIN +7 | Escherichia coli | - | 1999, 2000 | AF190695.1 | AAF05614.1 |
| blaTEM-17 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | ampicillin, amoxicillin +18 | Capnocytophaga ochracea +2 | Republic of Korea, United States | 2000, 2004, 2015, 2019 | Y14574 | CAA74912.2 |
| blaTEM-68 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, cefotaxime +15 | Klebsiella pneumoniae +1 | Poland | 2000 | AJ239002 | CAB92324.1 |
| blaTEM-12 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 12 | cefotaxime, AZTREONAM +16 | Escherichia coli +4 | Canada, China, United States, Mexico|Mexico City, Pittsburgh | 1992, 1999, 2000, 2004, 2015, 2020, 2023, 2024 | M88143 | AAA25053.1 |
| blaTEM-72 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | cefoxitin, cefotaxime +16 | Proteus mirabilis +3 | Italy, West Bengal, India | 2000, 2012, 2025 | AF157413|AF157553 | AAF19151.1 |
| blaTEM-1B | ResFinder DatabaseReslit | 298 | amoxicillin clavulanic acid, ampicillin +29 | Escherichia coli +86 | France, Spain, Honduras, China, Korea, Netherlands, Argentina, Nepal, Samoa|Vanuatu, Romania, Europe|Italy, Tanzania, Taiwan, Cambodia, Dublin, New Zealand, Pakistan, West Africa|Conakry, Guinea, Cameroon, Brazil, Hong Kong, Tunisia, United States, Thailand, UK|Latin America, Ghana, Singapore, Lebanon, Switzerland, Bangladesh|Pakistan|Nepal, China|Brazil|United Kingdom|Denmark, Canada, Ecuador, Pakistan|Denmark, India, Netherlands|Brazil|Argentina, St. Louis, MO, USA, Taiwan|Germany|Netherlands|United Kingdom|United States, Utah, Mexico, United Kingdom, Florida|North Central Florida, Italy|Far East countries, Germany|global, southwestern Nigeria, Japan, Lake Victoria, Tanzania, human, Philippines, Great Britain, Norway, Europe, Italy, Europe|UK, Oman, South Africa, Europe|Netherlands, Kenya|Malawi, Uruguay, Russia, Serbia, Guadeloupe|French West Indies, Jakarta, Egypt, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, Tokyo, Japan|Japan, Germany, Italy|Europe, Beijing, China|China, Europe|Poland, Australia, India|Pakistan|Bangladesh|Philippines|Democratic Republic of the Congo, Portugal, Europe|Spain, Africa|Gambia, North Carolina|USA, Denmark, Madagascar, Caribbean, Hungary, Senegal, Zambia, Saskatchewan, Ethiopia|Kenya, Southeast Nigeria, Norway|Japan|Bangladesh, Basque Country, northern Spain|Basque Country, South Australia|Australia, Alberta, Canada, Saudi Arabia, Croatia, Khon Kaen province, Thailand, Guadeloupe, Brazilian Amazon, Shandong Province, China, Yangzhou, China, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Ontario, Canada, Sweden, Belgium|The Netherlands|Europe, Czech Republic, Western Africa|Mali, Northern Nigeria, San Francisco, CA, USA, Bangladesh, Pakistan|Karachi, Pakistan, East Africa, Tamaulipas, Mexico, Uganda, Central Adriatic|Central Adriatic Sea, Europe|America|Africa, Kenya, Slovak Republic, East Africa|Uganda, Zanzibar, Denmark|Finland|Germany, Thailand|China|Spain|Switzerland|Israel|USA|Indonesia|Asia, Thailand|Pig|Pork, Accra, Ghana|Ghana, Ethiopia, Chennai, United States|Pakistan|Bangladesh|Nigeria|Iraq|India, Portugal|various regions, Nigeria, Vancouver, Canada, Somali region, Ethiopia|Somali Region, Ethiopia, Europe|Africa|North America|South America|Asia|Oceania, Sardinia, Hong Kong|mainland China|Australia|Canada|United States of America|South Africa|Taiwan|United Kingdom, Northern Italy, Ibadan, Nigeria, Greater Accra Region, Ghana|Ghana, Southern China, United Arab Emirates, Costa Rica, Shanghai, China, Shandong Province|adjacent regions in China, China|Shenzhen, China, Southern India|India, Atlanta, Shenzhen, China, China|United Kingdom|Argentina|Europe|Americas|Asia|Africa|Australasia|Vietnam|Switzerland|Thailand|Mexico, Normandy|France, Algeria, Middle East|Europe|Asia|South America|Peru|Egypt|Saudi Arabia|Denmark|Pakistan|Jordan|Iraq|Lebanon|China|Ghana | 2000, 2002, 2004, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AF190694|AF190695|AF190693|AF190692 | - |
| blaTEM-1C | ResFinder DatabaseReslit | 20 | amoxicillin clavulanic acid, ampicillin +14 | Escherichia coli +4 | France, Spain, Netherlands, UK|Latin America, Japan, United Kingdom, Spain|porcine, Germany, North Carolina|USA, South Australia|Australia, Alberta, Canada, United States, Denmark, Accra, Ghana|Ghana, Russia, Kenya, China | 2000, 2002, 2008, 2011, 2013, 2018, 2019, 2020, 2021, 2022, 2024, 2025 | AF190694|AF190695|AF190693|AF190692 | - |
| blaTEM-1D | ResFinder DatabaseReslit | 23 | amoxicillin clavulanic acid, ampicillin +17 | Escherichia coli +10 | France, South Korea, United Kingdom, Spain, Thailand|Nepal, India, Germany, Japan|France|United Kingdom|North America|South America|Europe|Asia/Oceania|Africa, South America|Australia|France|Vietnam|China, Bangladesh, Saudi Arabia, Ghana, South Asia|India|Bangladesh|Pakistan|Kenya, Ethiopia, China, Europe|South America|Asia|North Africa, Armenia | 2000, 2016, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AF190694|AF190695|AF190693|AF190692 | - |
| blaTEM-1E | Reslit | 1 | amoxicillin clavulanic acid | Escherichia coli | France | 2000 | AF190694|AF190695|AF190693|AF190692 | - |
| blaTEM-1F | Reslit | 1 | amoxicillin clavulanic acid | Escherichia coli | France | 2000 | AF190694|AF190695|AF190693|AF190692 | - |
| blaTEM-76 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, AMOXICILLIN +7 | Escherichia coli | - | 2000 | AF190694.1 | AAF05613.1 |
| blaTEM-78 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, AMOXICILLIN +7 | Escherichia coli | - | 2000 | AF190693.1 | AAF05612.1 |
| blaTEM-79 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, AMOXICILLIN +8 | Escherichia coli | Kuwait | 2000, 2023 | AF190692.1 | AAF05611.1 |
| blaTEM-81 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, AMOXICILLIN +7 | Escherichia coli | - | 2000 | AF427127.1 | AAL29433.1 |
| blaTEM-82 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, AMOXICILLIN +8 | Escherichia coli +1 | Portugal | 2000, 2022 | AF427128.1 | AAL29434.1 |
| blaTEM-83 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, AMOXICILLIN +7 | Escherichia coli | - | 2000 | AF427129.1 | AAL29435.1 |
| blaTEM-84 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, AMOXICILLIN +12 | Escherichia coli | Netherlands, South-West Nigeria | 2000, 2015, 2022 | AF427130.1 | AAL29436.1 |
| blaTEM-53 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | ceftazidime, cefotaxime +13 | Klebsiella pneumoniae | South Africa, Bangladesh|Brazil|Greece|Italy|Kenya|South Africa|Thailand|Uganda|Vietnam | 1999, 2001, 2024 | AF045475|AF117743|AF117744|AF117745|AF117746 | AAD22538.1 |
| blaTEM-63 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | ceftazidime, cefotaxime +14 | Klebsiella pneumoniae +5 | South Africa, Malawi, Bangladesh | 2001, 2004, 2019, 2023, 2025 | AF045475|AF117743|AF117744|AF117745|AF117746 | AAK17194.1 |
| blaTEM-92 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | ceftazidime, cefotaxime +13 | Proteus mirabilis +1 | France, Italy | 2001, 2005, 2020 | AF143804.1 | AAF66653.1 |
| blaTEM-90 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOTHIN +4 | Escherichia coli | - | 2001 | AF351241.1 | AAK30619.1 |
| blaTEM-88 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | ceftazidime, cefotaxime +14 | Klebsiella pneumoniae +1 | Korea, South Korea|Korea | 2001, 2002 | AY027590 | AAK14792.1 |
| blaTEM-15 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 13 | ceftazidime, cefotaxime +19 | Klebsiella pneumoniae +6 | Korea, France, Republic of Korea, Austria|Europe, Venezuela, Netherlands, Algeria | 1990, 2001, 2003, 2004, 2005, 2008, 2013, 2014, 2015, 2019, 2025 | AY027590 | CAO98721.1 |
| blaTEM-4 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | cefotaxime, ceftazidime +18 | Klebsiella pneumoniae +4 | Spain, Tunisia, Malaysia, India, Sub-Saharan Africa | 1989, 2002, 2003, 2015, 2019, 2021, 2023, 2025 | AY005110 | CDR98216.1 |
| blaTEM-87 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, aztreonam +11 | Proteus mirabilis +1 | Italy | 2002 | AF250872 | AAG44570.1 |
| blaTEM-80 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ampicillin, amoxicillin +11 | Enterobacter cloacae +1 | - | 2002 | AF347054 | AAM15527.1 |
| blaTEM-106 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 12 | AZTREONAM, TICARCILLIN +15 | Escherichia coli +2 | Czech Republic, Denmark, Yangzhou, China, Belgium|The Netherlands|Europe, Central Adriatic|Central Adriatic Sea, Europe, Nigeria | 2002, 2006, 2020, 2022, 2023, 2025 | AY101578.1 | AAM52207.1 |
| blaTEM-107 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | AZTREONAM, TICARCILLIN +10 | Klebsiella pneumoniae +1 | South Korea | 2002, 2011 | AY101764.1 | AAM52215.1 |
| blaTEM-71 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, cefotaxime +12 | Klebsiella pneumoniae +1 | - | 2002 | AF203816 | AAL03985.1 |
| blaTEM-1A | ResFinder DatabaseReslit | 31 | ampicillin, ticarcillin +16 | Escherichia coli +11 | Spain, Netherlands, Argentina, Cameroon, Thailand, Ghana, United States, Florida|North Central Florida, Spain|porcine, Brazil, Spain|France, Germany, Australia, North Carolina|USA, Boston, MA|Orange, CA, Chongqing, China, Ontario, Canada, Belgium|The Netherlands|Europe, Portugal, Portugal|various regions, Europe|Africa|North America|South America|Asia|Oceania, Algeria, China, United Arab Emirates | 2002, 2011, 2013, 2014, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AJ308558 | - |
| blaTEM-1f | Reslit | 1 | ampicillin, ticarcillin | Escherichia coli | Spain | 2002 | AJ308558 | - |
| blaTEM-30c | Reslit | 1 | ampicillin, ticarcillin | Escherichia coli | Spain | 2002 | AJ308558 | - |
| blaTEM-34b | Reslit | 1 | ampicillin, ticarcillin | Escherichia coli | Spain | 2002 | AJ308558 | - |
| blaTEM-40b | Reslit | 1 | ampicillin, ticarcillin | Escherichia coli | Spain | 2002 | AJ308558 | - |
| blaTEM-51a | Reslit | 1 | ampicillin, ticarcillin | Escherichia coli | Spain | 2002 | AJ308558 | - |
| blaTEM-95b | Reslit | 1 | ampicillin, ticarcillin | Escherichia coli | Spain | 2002 | AJ308558 | - |
| blaTEM-95 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOTHIN +4 | Escherichia coli | - | 2002 | AJ308558.1 | CAC67290.1 |
| blaTEM-103 | Card DatabaseReference Gene CatalogReslit | 4 | penicillin, BETA-LACTAM +1 | Escherichia coli BM4511 +4 | France, Australia | 2002, 2024 | NCBI:AF345225 | EAC0197234.1 |
| blaTEM-30 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 16 | amoxicillin, ticarcillin +17 | Escherichia coli +4 | Portugal, Poland, Madrid, Spain, China, United Kingdom, Czech Republic, Canada, Europe, Guangdong, China, United Arab Emirates | 1992, 2002, 2008, 2010, 2016, 2019, 2020, 2021, 2025 | AJ437107 | CAD24670.1 |
| bla(TEM-67) | Reslit | 1 | amoxicillin, amoxicillin clavulanic acid | Proteus mirabilis +1 | - | 2003 | AF091113 | - |
| blaTEM-67 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, AMOXICILLIN +8 | Proteus mirabilis +1 | Europe | 2003, 2005 | AF091113.2 | AAD33116.2 |
| blaTEM | Reslit | 851 | ampicillin, ceftazidime +26 | Klebsiella pneumoniae +292 | Australia, France, United States|Taiwan|Australia|South Africa|Turkey|Belgium|Argentina, United States, Spain, northeastern United States, France|Mali, Europe, North Carolina|Virginia, Peru|Bolivia, Bolivia, China, Canada, Texas, Thailand, Italy, United States|Iraq|Germany, Kuwait, Malaysia, Germany, California, Arctic Svalbard, Galápagos Archipelago, India, Ireland, Barcelona, Korea, Tunisia, Iran, South-Eastern Nigeria, Eastern Cape Province, South Africa, Colombia, Dhaka, Bangladesh, Egypt|Pakistan, Mexico|San Pedro River, Mexico, Turkey, Manaus, State of Amazonas, Brazil, Lake Taihu, Brazil, North Eastern India, Alaska|USA, Eastern China, Japan, Oslo fjord, Bangladesh, South Korea, Nepal, South West London, UK, Southern Taiwan, Poland, Northwestern Libya, Okinawa Prefecture, Japan, Austria, Michigan|California, Romania, South Africa, Algeria|France, southwestern Nigeria, Nigeria, Hong Kong, Heilongjiang province, China, Israel|Hawaii, northeast India, Netherlands, Eastern Cape, South Africa, Benin, Northern Ireland, Portugal, Ghana, Zambia, Ecuador, Greece, Egypt, Taiwan, Southwestern Nigeria, North Central Florida, Saudi Arabia, Ethiopia, Guadeloupe, England|USA|Canada, Zimbabwe, Algeria, Houston, Texas|Texas, Kenya, West Bengal, Saraburi Province, Thailand, Europe|seafood, Andhra Pradesh, India, Al-Najaf Province, Iraq, Philadelphia, Pennsylvania, Sri Lanka, United Kingdom, Qatar, Northern California, Northwest China, South Asia|sub-Saharan Africa|The Gambia|Mali|Kenya|Mozambique|Bangladesh|India|Pakistan, Heilongjiang Province, China, Sudan, Thailand|Japan, Pakistan, central Negev Desert, Israel, Mexico City, Senegal, Chile, Al-Najaf City, Iraq, South India, East Java, Indonesia, Shenzhen, southern China, UK, Russia, Northern Thailand, Shandong province, China, USA, Barcelona, Spain, Henan, China, Chattogram, Bangladesh, north-central Iran, Enugu, Nigeria, North-West Province, South Africa, Port-Harcourt, Nigeria, Denmark, Tai'an, China, Brazilian Amazon|Brazil, Shandong Province, China, Portugal|Spain|France, Vietnam, Brazil|Santa Catarina|Minas Gerais|Paraná|São Paulo|Rio de Janeiro|Rio Grande do Sul, Southern China, northern Xinjiang, China|China, North America|South America, mid-Adriatic coast, Southern India, Greater Accra region, Ghana, West Cameroon, Embu Town|Kangaru Market, Kashmir valley, India, Europe|Czech Republic|Slovak Republic, Shandong, China, Upper Egypt, Eastern Cape Province, Republic of South Africa|South Africa, Panama, Sicily|Southern Italy, Emilia Romagna|Italy, Dominican Republic, Taiwan|Taipei, Taiwan, Tehran, southeastern China, Northern Californian|California, Guizhou, China, Alberta|Canada, Eastern Cape Province, South Asia|Southeast Asia|India|Thailand|Cambodia|Vietnam|Egypt|Jordan|China, Indonesia, Peru, East China, Portugal|Porto, Northern Lebanon, Philippines, Morocco, Kingdom of Saudi Arabia, India|Malaysia|South China, KwaZulu-Natal, South Africa, sub-Saharan Africa|Burkina Faso|Ghana|Guinea-Bissau|Kenya|Senegal, Montenegro, Southern Thailand|Thailand, Kelantan|Terengganu, East Coast Peninsular Malaysia, Nicaragua, Western Algeria, Guangdong Province, Arusha|Mwanza, Europe|United Kingdom, Asia|Pacific, North Jordan, Northeastern Ohio, the United States|Northeastern Ohio, Uganda|Kenya, Bosnia and Herzegovina, Zhanjiang, China, Kanto Region, Japan, Europe|Netherlands, Europe|Italy, Botswana, Romania|France, Europe|North America|Netherlands|Denmark|Pennsylvania|United States|France, Upper Gulf of Thailand|Thailand|Ireland, Port Said Governorate|Mediterranean Sea, Tibet, Georgia, USA|Georgia, Hubei, China|China, Kiambu County, Kenya, Accra, Ghana, Cameroon, Shandong Province|China, Southern Brazil, Eastern Cape province, South Africa|South Africa, Germany|Poland|Denmark, Mid-Atlantic United States, North Sea|Baltic Sea, South America|Chile, Kurdistan–Iraq, West Bengal, India, Europe|Western Pacific|Africa|Kenya|Morocco|Qatar|South Africa|Uganda, Burkina Faso, Southwest Nigeria, Sonora|Mexico, Nakhon Ratchasima Province, Thailand, India|Thailand|Vietnam|Myanmar|Denmark|Germany|Algeria|Portugal|Spain|Brazil|United States, China|global, Benin|Belgium, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Quito|Ecuador, Gaza strip, Edo State, Nigeria, China|Guangzhou, China, Anhui, China, Northern Kazakhstan, north-central Nigeria, Uganda, Boeotia regional district, Greece, Van province, Turkey, Sicily, Europe|Portugal, Africa|Asia|Europe|North America|South America|Oceania, Himachal Pradesh, Bulgaria, Mali, Namwala District, Zambia, Mexico, Marmara Sea, Shanxi Province|Shanxi Province, China, Gaza Strip, Czech Republic, Shandong Province, Ogun state, East Tennessee, Canada|Newfoundland, Canada, Iraq, Northwestern Nigeria, South-Eastern Bangladesh|Bangladesh, Türkiye, West Java|Indonesia, Bangkok, Thailand, Indonesia|Lombok Island, Punjab, Pakistan, Southeast Nigeria, Istanbul, Türkiye|Istanbul, Turkey, Jordan, Guangdong, China, Southern Thailand, North Sinai|South Sinai, Egypt, Europe|Poland, Palestine, Anhui province, China, Côte d'Ivoire, South-west Nigeria, Europe|various food origins, Iran|India|Bangladesh|China|Nepal|Ethiopia|Russia|Pakistan|Egypt|Brazil, Finland, northern India, Addis Ababa, Ethiopia|Ethiopia, Europe|Greece, Lusaka, Zambia, Central Italy, France|Germany|Netherlands|Norway|Spain|United Kingdom|Europe, Khartoum, Sudan|Egypt, USA|China|Japan|Spain|United Kingdom|Germany|France|South Korea|Netherlands|Viet Nam|Laos|Canada|Czech Republic|Argentina|Brazil|Belgium|Denmark|Iran|Australia|Croatia|Ghana|Mexico|Missing, Europe|Africa|North America|South America|Asia|Oceania, Gulf Cooperation Council countries|Gulf Cooperation Council|Gulf Cooperation Council region, Tanzania|Pakistan, Kentucky|USA, Central Macedonia|Epirus|Greece, Athens, GA, West Nusa Tenggara, Indonesia, Middle Upper Egypt, Sweden, mariculture areas, Cambodia, Europe|Turkey, Northern Italy, Kitwe, Zambia, Scotland|England, Chiang Mai, Thailand|Thailand, Western Nepal, Calgary, Canada|Calgary, Alberta, Canada, Wuhan, Egypt|various locations, Ashanti Region, Ghana, United Arab Emirates, Kisii, Kenya|Kenya, South Lebanon, Southwest China, Yamoussoukro, Côte d’Ivoire, Surabaya, Indonesia, United States|Europe|Russia|Canada|Australia|global, Southern Benin|Benin, Europe|Türkiye, Kathmandu, Nepal|Kathmandu Valley, Europe|Iraq, Egypt|Garbia Governorate, Egypt, Turkiye, India|Delhi NCR, Upper Egypt|Egypt, China|Thailand|USA|Spain|Norway|Japan|Vietnam|Hong Kong, Central Adriatic Sea, Southeastern Nigeria|Nigeria, Egypt|Northern Egyptian governorates of Kafr El-Sheikh and Dakahlia, Central China, India|China|Brazil, Can Tho City, Vietnam | 1988, 1997, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AY123253 | - |
| blaTEM-102 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | AZTREONAM, TICARCILLIN +12 | Plasmid pWW100 +1 | - | 2003, 2018 | AY040093.1 | AAK82652.1 |
| blaTEM-91 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | ceftazidime, AZTREONAM +10 | Escherichia coli | Japan, United States | 2003, 2019 | AB049569 | BAB16308.1 |
| blaTEM-8 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Klebsiella pneumoniae | - | 1989, 1992 | X65252 | CAA46344.1 |
| blaTEM-16 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Klebsiella pneumoniae | - | 1988, 1992 | X65254 | CAA46346.1 |
| blaTEM-24b | Reslit | 2 | ceftazidime, cefotaxime +2 | Enterobacter aerogenes +5 | France | 2003, 2005 | AY259119 | - |
| blaTEM-19 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | ceftazidime, cefotaxime +18 | Klebsiella pneumoniae +4 | France, Republic of Korea, Poland, Houston, Texas|Houston, TX, Pittsburgh, United States | 1990, 2003, 2004, 2008, 2013, 2023, 2024, 2025 | AY259119 | AFN21551.1 |
| blaTEM-11 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | ceftazidime, AZTREONAM +11 | Escherichia coli +2 | Canada, Italy | 1990, 2004, 2005, 2012 | AF535127|AF535128|AF535129|AF535130|AY243512 | AAW66604.1 |
| blaTEM-115 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, AZTREONAM +9 | Klebsiella pneumoniae +1 | Canada | 2004 | AF535127|AF535128|AF535129|AF535130|AY243512 | AAN04881.1 |
| blaTEM-120 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, AZTREONAM +9 | Klebsiella oxytoca | Canada | 2004 | AF535127|AF535128|AF535129|AF535130|AY243512 | AAO85882.1 |
| blaTEM-122 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, AMOXICILLIN +7 | Escherichia coli | - | 2004 | AY307100.1 | AAQ98890.1 |
| blaTEM-116 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 34 | TICARCILLIN, CEPHALOTHIN +19 | Staphylococcus aureus +25 | Italy, Tunisia, Brazil, India, poultry, Taiwan, Croatia, Delhi|India, Cameroon, Qatar, Kashmir valley, India, Europe, United States, Thailand, China|Shanghai, China, Northern Kenya, China, Michigan|United States, Namib Desert, France, Shanghai, China, Slovak Republic, Kazakhstan | 2004, 2006, 2011, 2013, 2015, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | U36911.1 | AAB39956.1 |
| blaTEM-47 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | ceftriaxone, ceftazidime +13 | Serratia marcescens +2 | Poland, Warsaw, Poland | 1998, 2004 | Y10279|Y10280|Y10281 | CAA71322.1 |
| blaTEM-112 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | AZTREONAM, TICARCILLIN +12 | Escherichia coli +2 | Algeria | 2004, 2019, 2021, 2024 | AY589493.1 | AAS89982.1 |
| blaTEM-113 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Proteus mirabilis | - | 2004 | AY589494.1 | AAS89983.1 |
| blaTEM-114 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Klebsiella aerogenes | - | 2004 | AY589495.1 | AAS89984.1 |
| blaTEM-126 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | AZTREONAM, TICARCILLIN +15 | Escherichia coli +5 | Denmark, Central Adriatic|Central Adriatic Sea, Manitoba, Canada, Nigeria | 2004, 2005, 2022, 2023, 2024 | AY628199.1 | AAT45742.1 |
| blaTEM-108 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Salmonella enterica subsp. enterica serovar Typhimurium | - | 2004 | AF506748.1 | AAM28884.1 |
| blaTEM-129 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Klebsiella oxytoca | - | 2004 | AJ746225.1 | CAG34105.1 |
| blaTEM-131 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | cephalosporins, AZTREONAM +9 | Salmonella enterica serotype Isangi +2 | South Africa | 2004 | AY436361 | AAR10958.1 |
| blaTEM-121 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, aztreonam +14 | Enterobacter aerogenes +3 | France | 2004 | AY307374 | AAQ01671.1 |
| blaTEM-127 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOTHIN +5 | Escherichia coli | Denmark | 2004, 2022 | AY368236.1 | AAR89358.1 |
| blaTEM-128 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | TICARCILLIN, CEPHALOTHIN +6 | Escherichia coli +1 | Fujian Province, Southeast China|China | 2004, 2024 | AY368237.1 | AAR89359.1 |
| blaTEM-135 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 29 | TICARCILLIN, CEPHALOTHIN +14 | Salmonella enterica subsp. enterica serovar Typhimurium +5 | Argentina, Korea, United Kingdom, Spain|porcine, Germany, Czech Republic, New Zealand, Victoria, Australia, Colombia, Denmark, Yangzhou, China, South-West Nigeria, global, Guangdong, China, China, Kathmandu, Nepal, Sub-Saharan Africa, Europe|Poland, Kenya | 2005, 2015, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AJ634602.1 | CAG25427.1 |
| blaTEM-134 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, cefotaxime +10 | Citrobacter koseri +1 | Italy | 2005 | AY574271 | AAS79107.1 |
| blaTEM-85 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | ceftazidime, cefotaxime +11 | Klebsiella pneumoniae +1 | Poland | 2005, 2021 | AJ277414|AJ277415|AJ318093|AJ318094 | CAC43229.1 |
| blaTEM-86 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, cefotaxime +10 | Klebsiella pneumoniae +1 | Poland | 2005 | AJ277414|AJ277415|AJ318093|AJ318094 | CAC43230.1 |
| blaTEM-93 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | ceftazidime, cefotaxime +14 | Klebsiella pneumoniae +2 | Poland, Italy | 2005, 2006, 2012 | AJ277414|AJ277415|AJ318093|AJ318094 | CAC85660.1 |
| blaTEM-94 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, cefotaxime +10 | Klebsiella pneumoniae +1 | Poland | 2005 | AJ277414|AJ277415|AJ318093|AJ318094 | CAC85661.1 |
| blaTEM-133 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Klebsiella pneumoniae | - | 2005 | AY528425.1 | AAS19171.1 |
| blaTEM-132 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, cefotaxime +10 | Klebsiella pneumoniae +1 | Slovakia | 2005 | AY491682 | AAR84298.1 |
| blaTEM-109 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | amoxicillin, ticarcillin +15 | Escherichia coli | - | 2005 | AY628175 | AAT46413.1 |
| blaTEM-144 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, AZTREONAM +9 | Salmonella enterica serovar Derby +3 | Uruguay | 2006 | AM049399|AM049400 | CAJ17558.1 |
| blaTEM-136 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Klebsiella pneumoniae | - | 2006 | AY826417.1 | AAV83795.1 |
| blaTEM-105 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | BETA-LACTAM, UNKNOWN BETA-LACTAM +11 | Escherichia coli +7 | Brazil, China|Canada|Switzerland|USA|Italy, Germany, Norway, Bangladesh|India|China|France|Brazil, India, South Africa | 2007, 2021, 2022, 2023, 2024, 2025 | AF516720.1 | AAM61953.1 |
| blaTEM-6 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | AZTREONAM, TICARCILLIN +13 | Escherichia coli | Sub-Saharan Africa | 1987, 1991, 2025 | X57972 | CAA41038.1 |
| blaTEM-125 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | ceftazidime, AZTREONAM +14 | Escherichia coli +2 | France, Algeria | 2006, 2024 | AY628176 | AAT46414.1 |
| blaTEM-138 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, cefotaxime +10 | Salmonella enterica serovar Infantis +2 | Tunisia | 2006 | AY853593 | AAW47922.1 |
| blaTEM-151 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, AZTREONAM +13 | Escherichia coli | - | 2007 | DQ834729|DQ834728 | ABI74448.1 |
| blaTEM-152 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, AZTREONAM +13 | Escherichia coli | - | 2007 | DQ834729|DQ834728 | ABI74447.1 |
| blaTEM-52C | ResFinder DatabaseReslit | 11 | AZTREONAM, TICARCILLIN +13 | Salmonella enterica subsp. enterica serovar Typhimurium +4 | Netherlands, Estonia, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, The Netherlands, Belgium, Spain | 2007, 2013, 2015, 2019, 2021, 2023, 2025 | EF141186 | - |
| blaTEM-139 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Klebsiella pneumoniae | - | 2007 | DQ072853.1 | AAZ23494.1 |
| blaTEM-137 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Shigella sonnei | - | 2007 | AM286274.1 | CAL08007.1 |
| blaTEM-158 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, AZTREONAM +13 | Escherichia coli BER1 +3 | - | 2007 | EF534736 | ABQ00181.1 |
| blaTEM-141 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | TICARCILLIN, CEPHALOTHIN +12 | Enterobacter cloacae +5 | Guangdong, China, Hong Kong|mainland China|Australia|Canada|United States of America|South Africa|Taiwan|United Kingdom, Djibouti, China|United Kingdom|Argentina|Europe|Americas|Asia|Africa|Australasia|Vietnam|Switzerland|Thailand|Mexico | 2007, 2022, 2025 | AY956335.1 | AAX56615.1 |
| blaTEM-154 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +12 | Escherichia coli | - | 2007 | FJ807656.1 | ACO07310.1 |
| blaTEM-149 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, cefotaxime +11 | Enterobacter aerogenes +3 | Italy | 2008 | DQ369751 | ABC96711.1 |
| blaTEM-110 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOTHIN +4 | Klebsiella pneumoniae | - | 2008 | AY072920.1 | AAL68923.1 |
| blaTEM-159 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, AMOXICILLIN +7 | Proteus mirabilis | - | 2008 | EF136376.1 | ABM54869.1 |
| blaTEM-160 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, AMOXICILLIN +7 | Proteus mirabilis | - | 2008 | EF136377.1 | ABM54870.1 |
| blaTEM-48 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | cephalosporins, aztreonam +11 | Serratia marcescens +1 | Poland | 1998, 2008 | AM931008 | CAA71323.1 |
| blaTEM-157 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | AZTREONAM, TICARCILLIN +10 | Enterobacter cloacae +1 | - | 2008, 2019 | DQ909059.1 | ABI81768.1 |
| TEM | Reslit | 43 | cefpodoxime, cefotaxime +19 | Escherichia coli +27 | Manitoba, Taiwan, Malaysia, Iran, Vietnam, North of Iran, South Korea, Delhi, India, Egypt, South India, South Western Nigeria, Karachi, India, Kenya, Tanzania, Michigan, USA, South Asia|Southeast Asia|Sub-Saharan Africa|East Asia|North Africa and Middle East, Nigeria, Europe, Upper Egypt, Central China|China, China, Jordan, Netherlands, Poland, Iraq, Hebei Province|China|Hebei Province, China, South Africa, Ho Chi Minh City, Vietnam, Turkey, Europe|China | 2007, 2010, 2011, 2013, 2015, 2017, 2018, 2019, 2020, 2022, 2023, 2024, 2025, 2026 | KY706079|KY706080|KY753816 | - |
| blaTEM-155 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, ceftriaxone +11 | Escherichia coli +1 | - | 2009 | DQ679961|AY263404|J194944|FJ483937 | ABG77582.1 |
| blaTEM-168 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | ampicillin, ampicillin sulbactam +15 | Escherichia coli N08-1503 +3 | Norway | 2009, 2023 | FJ919776 | ACR22829.1 |
| blaTEM-164 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | AZTREONAM, TICARCILLIN +9 | Klebsiella pneumoniae +1 | West Bengal, India | 2009, 2025 | EU274580.1 | ABX71157.1 |
| blaTEM-10 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 14 | cefotaxime, ceftazidime +18 | Escherichia coli +5 | United States, Mexico|Mexico City, Global, Central Greece, Pittsburgh, St. Louis, Missouri, Portugal | 1989, 1997, 1998, 1999, 2010, 2021, 2023, 2024 | AF093512.1 | AAC72362.1 |
| blaTEM-130 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Klebsiella pneumoniae | - | 2010 | AJ866988.1 | CAI29263.1 |
| blaTEM-33 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | amoxicillin clavulanic acid, TICARCILLIN +14 | Escherichia coli +2 | Madrid, Spain, India, Norway|Asia, Malaysia, UK, South Australia|Australia, Hong Kong|mainland China|Australia|Canada|United States of America|South Africa|Taiwan|United Kingdom | 1999, 2010, 2013, 2018, 2021, 2022, 2025 | GU371926 | ADL13944.1 |
| blaTEM-34 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | amoxicillin clavulanic acid, TICARCILLIN +13 | Escherichia coli +2 | Madrid, Spain, Kuwait, Hong Kong|mainland China|Australia|Canada|United States of America|South Africa|Taiwan|United Kingdom, Iowa, United States | 1994, 2010, 2013, 2023, 2025 | KC292503 | AGE11905.1 |
| blaTEM-40 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | amoxicillin clavulanic acid, ampicillin +11 | Escherichia coli | Madrid, Spain, Spain|porcine, South-West Nigeria | 1995, 2010, 2020, 2022 | CP029493.1|NZ_CP017246.1|KX276657.1|KU341381.1|U62007.2|KU994859.1|JX258654.1|NC_020271|NC_011739.1|EU935740|CP015071.1|MF684783.1|J01566.1|NC_017650.1|SAMN11936814|SAMN11936815|SAMN11936816|SAMN11936817|SAMN11936818|SAMN11936819|SAMN11936820|SAMN11936821|SAMN11936822|SAMN11936823|SAMN11936824 | CBX53726.1 |
| blaTEM-54 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | amoxicillin clavulanic acid, ampicillin +10 | Escherichia coli | Madrid, Spain, Spain|porcine | 1999, 2010, 2020 | CP029493.1|NZ_CP017246.1|KX276657.1|KU341381.1|U62007.2|KU994859.1|JX258654.1|NC_020271|NC_011739.1|EU935740|CP015071.1|MF684783.1|J01566.1|NC_017650.1|SAMN11936814|SAMN11936815|SAMN11936816|SAMN11936817|SAMN11936818|SAMN11936819|SAMN11936820|SAMN11936821|SAMN11936822|SAMN11936823|SAMN11936824 | AAD22539.1 |
| blaTEM-183 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | TICARCILLIN, CEPHALOTHIN +6 | Klebsiella pneumoniae +2 | Norway, Michigan|United States | 2011, 2023 | HQ529916.1 | ADR71220.1 |
| bla(TEM) | Reslit | 5 | ceftazidime, ceftriaxone +8 | Escherichia coli +1 | North-India, China, Egypt, Nepal, Indonesia | 2011, 2021, 2023 | - | - |
| blaTEM-171 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | BETA-LACTAM, UNKNOWN BETA-LACTAM +5 | Escherichia coli +2 | Hong Kong, SAR, China|Hong Kong, China, Norway | 2012, 2017, 2021, 2023 | GQ149347.1 | ADA79630.1 |
| bla(TEM-1) | Reslit | 5 | ampicillin, cefoxitin +3 | Escherichia coli +1 | India, Toronto, Europe, Osaka, Japan | 2012, 2018, 2021, 2022 | MW548582 | - |
| blaTEM-186 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOTHIN +4 | Escherichia coli | - | 2012 | JN227084.1 | AET99222.1 |
| blaTEM-111 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, ceftriaxone +3 | Proteus mirabilis +1 | Italy | 2012 | AF468003.1 | AAL77062.1 |
| blaTEM-185 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, CEPHALOTHIN +9 | Escherichia coli | - | 2012 | JF795538.1 | AEG64812.1 |
| blaTEM-191 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN +4 | Acinetobacter baumannii +3 | Guangdong, China | 2012, 2015, 2020, 2025 | KY432484.1 | APY23677.1 |
| blaTEM-188 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Salmonella enterica | - | 2012 | JN211012.1 | AEL17198.1 |
| blaTEM-177 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Proteus mirabilis | - | 2013 | FN652295.1 | CBJ06718.1 |
| blaTEM-182 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, AMOXICILLIN +7 | Haemophilus parainfluenzae | - | 2013 | HQ317449.1 | ADP20705.1 |
| blaTEM-187 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ampicillin, amoxicillin +18 | Proteus mirabilis +1 | France | 2013 | HM246246 | ADM61585.1 |
| blaTEM-153 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, cefotaxime +10 | Escherichia coli | Portugal | 2013 | KC149518 | AGA83484.1 |
| blaTEM-176 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 12 | BETA-LACTAM, UNKNOWN BETA-LACTAM +10 | Escherichia coli +2 | Bangladesh, Poland, Guangdong, China, Kathmandu, Nepal, Peru, Egypt, United Arab Emirates | 2013, 2023, 2024, 2025 | GU550123.1 | ADB90239.1 |
| blaTEM-70 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | BETA-LACTAM, UNKNOWN BETA-LACTAM +2 | Escherichia coli +1 | Norway | 2013, 2023 | AF188199.1 | AAF01046.1 |
| bla_TEM | Reslit | 5 | ampicillin, cephalosporins +8 | Klebsiella pneumoniae +2 | Iran, North Carolina|China, Germany, China | 2013, 2017, 2021, 2023, 2024 | PRJNA293224|KP090413 | - |
| blaTEM-1 like | Reslit | 1 | ceftazidime, cefotaxime | Escherichia coli +1 | India | 2013 | JN002395|JF973688|KC699842|KC699843 | - |
| blaTEM-195 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Acinetobacter baumannii | - | 2014 | JN935137.1 | AFC75525.1 |
| blaTEM-96 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Escherichia coli | - | 2014 | AY092401.1 | AAM22276.1 |
| blaTEM-201 | Card DatabaseReference Gene CatalogResFinder Database | 4 | BETA-LACTAM, UNKNOWN BETA-LACTAM | Escherichia coli | - | 2014 | JX310327.1 | AFS44742.1 |
| bla(TEM-135) | Reslit | 1 | penicillin | Neisseria gonorrhoeae | Global | 2014 | - | - |
| blaTEM-220 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | BETA-LACTAM, UNKNOWN BETA-LACTAM +2 | Neisseria gonorrhoeae +1 | Argentina, Denmark | 2015, 2022 | KM998962.1 | AIW68620.1 |
| blaTEM-163 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | amoxicillin clavulanic acid, TICARCILLIN +8 | Escherichia coli | Argentina | 2014 | KP097715|EU815939 | ACF32746.1 |
| blaTEM-52StPaul | Reslit | 1 | cefoxitin, cefotaxime +1 | Escherichia coli | Netherlands | 2015 | KP860987 | - |
| tem | Reslit | 6 | penicillin, cephalosporins +5 | Enterobacteriaceae +8 | Germany, Seoul|Cheonan, Egypt, Inner Mongolia, Singapore | 2015, 2017, 2021, 2022, 2024 | KX214665|KX214664|KX214663|KX214662 | - |
| blaTEM-like | Reslit | 3 | ampicillin, cephalosporins +1 | Escherichia coli +3 | Peru, Brazil | 2015, 2025 | - | - |
| blatem | Reslit | 3 | ampicillin, cefoxitin +3 | Escherichia coli | Eastern Cape Province, South Africa, Spain, Central Zone of Mexico|Mexico | 2015, 2017, 2025 | PRJNA362530 | - |
| blaTEM-61 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Serratia marcescens | - | 1989 | LC542923.1 | BCD58813.1 |
| blaTEM-167 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Escherichia coli | - | 2016 | FJ360884.1 | ACJ04051.1 |
| bla_tem-1 | Reslit | 2 | ampicillin, amoxicillin | Salmonella enterica +2 | USA|Australia|Canada|Japan|France|Madagascar|China|Thailand|Germany, China | 2017, 2023 | CP009409|CP009410|CP009411|CP009412|CP009413|CP009414 | - |
| blaTEM - 1 | Reslit | 1 | ampicillin, cephalothin | Shigella flexneri | China | 2017 | - | - |
| blaTEM -1 | Reslit | 1 | ampicillin, ticarcillin | Pseudomonas putida +1 | United States|coastal wetlands | 2017 | KX863568|KX863570|KX863569|KX863571|KF245926.1|KY018700 | - |
| blaTEM-52B | ResFinder DatabaseReslit | 6 | cefotaxime, cefotaxime clavulanic acid +13 | Salmonella enterica serovar Virchow +5 | Ghana, Netherlands, Japan, Belgium, Belgium|The Netherlands|Europe | 2018, 2019, 2021, 2023 | PRJN335586 | - |
| blaTEM-184 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, aztreonam +11 | Escherichia coli +1 | - | 2018 | FR848831 | CCA61905.1 |
| bla(TEM-1b) | Reslit | 1 | ampicillin, penicillin | Escherichia coli +1 | China | 2018 | JN232517|KJ020575|MG197488|MG197489|MG197490|MG197491|MG197492|MG197493|MG197494|MG197495|MG197496|MG197497|MG197498|MG197499|MG197500|MG197501|MG197502|MG197503|LN897474|LN897475|KT879914|KY865321|KT990220|KU321583|CP017633|JQ432559|AP005147|CP022157|CP020856|DQ449578|KY986974|FJ621588|KP722020|LN735561|EU696790 | - |
| bla_TEM-1B | Reslit | 1 | ampicillin, penicillin | Escherichia coli | Germany|Kosovo|Ukraine|Afghanistan | 2023 | - | - |
| blaTEM-IB | Reslit | 1 | beta lactams | Escherichia coli | Europe | 2018 | PRJNA449634 | - |
| blaTEM-101 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | AZTREONAM, TICARCILLIN +9 | Escherichia coli +1 | China|Canada|Switzerland|USA|Italy | 1988, 2021 | AF495873.1 | AAM18924.1 |
| blaTEM-1B_1 | Reslit | 2 | ampicillin, beta lactams | Salmonella enterica subsp. enterica serovar Enteritidis +1 | Kuwait, Hanoi, Vietnam | 2019, 2023 | PRJNA363099 | - |
| blaTEM-104E | Reslit | 1 | penicillin | Escherichia coli | Tanzania|Thailand|human|swine | 2019 | - | - |
| blaTEM-104K | Reslit | 1 | penicillin | Escherichia coli | Tanzania|Thailand|human|swine | 2019 | - | - |
| blaTEM-164R | Reslit | 1 | penicillin | Escherichia coli | Tanzania|Thailand|human|swine | 2019 | - | - |
| blaTEM-238S | Reslit | 1 | penicillin | Escherichia coli | Tanzania|Thailand|human|swine | 2019 | - | - |
| bla_TEM-1 | Reslit | 3 | beta lactams, ampicillin +2 | Escherichia coli +2 | South Korea, Kenya, Ghana | 2020, 2023, 2024 | - | - |
| blaTEM-52 B | Reslit | 1 | cefoxitin | Escherichia coli | Denmark | 2019 | PRJEB14641|PRJEB14086 | - |
| BlaTEM | Reslit | 2 | ampicillin | Escherichia coli | Hong Kong, Egypt | 2019, 2025 | PRJEB33545 | - |
| blaTEM-14 | Reslit | 1 | cefoxitin, cefotaxime +1 | Escherichia coli | Ghana | 2019 | - | - |
| blaTEM-1 B | Reslit | 1 | ampicillin | Escherichia coli | India | 2020 | PRJNA543974 | - |
| blaTEM– 1 | Reslit | 1 | penicillin | Escherichia coli | China | 2020 | CP032986|CP032987|CP032988|CP032989|CP032990|CP032991|CP032992|CP032993|CP032994|CP032995 | - |
| blaTEM–1B | Reslit | 4 | ampicillin, penicillin +5 | Escherichia coli O80:H26 +4 | Spain, China | 2020, 2021, 2022 | CP043217|CP043221|CP043222|CP043224|CP043214|CP043215|CP043216|SRP219110|PRJNA560883 | - |
| blaTEM-IRTs | Reslit | 1 | ceftazidime avibactam | Klebsiella pneumoniae | Houston | 2020 | - | - |
| bla(TEM-1B) | Reslit | 1 | piperacillin tazobactam | Escherichia coli | Europe|UK | 2020 | CP043222|CP043223 | - |
| blaTEM–191 | Reslit | 1 | ampicillin, ampicillin sulbactam +1 | Klebsiella pneumoniae | China | 2020 | CP051490|CP051491|CP051492 | - |
| blaTEM–1 | Reslit | 5 | ampicillin, ampicillin sulbactam +9 | Klebsiella pneumoniae +3 | China, Finland|Eastern Finland, Spain|Asturias, Northern Spain, Norway | 2020, 2021, 2022 | CP051490|CP051491|CP051492 | - |
| blaTEM-1A/B | Reslit | 1 | beta lactams | Escherichia coli | Gambia | 2021 | CP053258|CP053259 | - |
| blaTEM–W60 | Reslit | 1 | beta lactams beta lactamase inhibitors | Escherichia coli W60 +1 | Europe | 2020 | CP058342|CP058343|CP058344 | - |
| blaTEM-50 | Reslit | 3 | cephalosporins, beta lactamase inhibitors +3 | Escherichia coli +1 | - | 2021, 2023, 2024 | - | - |
| blaTEM– 150 | Reslit | 1 | cefoxitin, ceftriaxone +5 | Klebsiella pneumoniae | Romania | 2020 | PRJNA579879 | - |
| blaTEM-244 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Escherichia coli | - | 2021 | MZ026156.1 | QWY17601.1 |
| blaTEM-43 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | penicillin, cephalosporins +12 | Klebsiella pneumoniae +1 | St. Louis, Missouri | 1998, 2021 | U95363 | AAC32889.2 |
| bla_TEM-1b | Reslit | 1 | penicillin, cephalosporins | Enterobacterales | Vietnam | 2021 | AP018565|AP018566|AP018567|AP018568|AP018571|AP018572|AP018577|AP018578|AP018579|AP018580|AP018581|AP018582|AP018583|AP018584|CP021952|CP040884|CP041930|CP043383|CP034846|CP026053|CP041177|PRJDB6655 | - |
| blaTEM-263 | Reference Gene Catalog | 1 | BETA-LACTAM | Klebsiella pneumoniae | - | 2021 | DBFPZU010000060.1 | HGW1440919.1 |
| TEM-OSBL | Reslit | 1 | ampicillin, cephalosporins | Escherichia coli +1 | India|Ghana|Nepal|Laos | 2022 | - | - |
| blaTEM-350 | Reslit | 1 | cephalosporins | Escherichia coli | Milwaukee, Wisconsin, USA|USA | 2022 | CP091427|CP091428|CP091429 | - |
| blaTEM–1b | Reslit | 1 | ampicillin, amoxicillin | Enterobacter quasiroggenkampii +6 | Edo state, Nigeria | 2022 | JAIKTX000000000|JAIKUW000000000|JAIKTX010000000|JAIKUW010000000 | - |
| blaTEM–1c | Reslit | 1 | ampicillin, amoxicillin | Escherichia coli +2 | Edo state, Nigeria | 2022 | JAIKTX000000000|JAIKUW000000000|JAIKTX010000000|JAIKUW010000000 | - |
| blaTEM-family | Reslit | 1 | ampicillin, cefoxitin | Escherichia coli | South Korea | 2022 | PRJNA757225 | - |
| blaTEM-P14S | Reslit | 1 | ampicillin | Neisseria gonorrhoeae | Colombia | 2022 | CP097461|CP097460|CP097459|CP097458|PRJNA835124 | - |
| blaTEM-52A | Reslit | 1 | amoxicillin, ampicillin | Escherichia coli | Belgium|The Netherlands|Europe | 2023 | - | - |
| blaTEM-28 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ampicillin, penicillin +10 | Escherichia coli | Australia | 1996, 2023 | PRJNA842786|PRJNA858941 | AAC32891.1 |
| blaTEM-S7 | Reslit | 1 | ampicillin | Escherichia coli | Kuwait | 2023 | ERR10468513|ERR10468514|ERR10468515|ERR10468516|ERR10468517|ERR10468518|ERR10468519|ERR10468520|ERR10468521 | - |
| blaTEM-116* | Reslit | 2 | penicillin, ampicillin | Escherichia coli | - | 2024 | NCBI accession U36911 | - |
| blaTEM-1B/C | Reslit | 1 | penicillin | Klebsiella pneumoniae | UK | 2024 | CP137420|CP137421|CP137422|CP137423|CP137403|CP137404|CP137405|CP137386|CP137387|CP137388|CP137389|CP137390|CP137396|CP137397|CP137398|CP137399|CP137400|CP137401|CP137402|CP137379|CP137380|CP137381|CP137382|CP137383|CP137384|CP137385|CP137375|CP137376|CP137377|CP137378|CP137369|CP137370|CP137371|CP137372|CP137373|CP137374|CP137431|CP137432|CP137433|CP137434|CP137435|CP137362|CP137363|CP137364|CP137365|CP137366|CP137367|CP137368|CP137424|CP137425|CP137426|CP137427|CP137428|CP137429|CP137430|CP137357|CP137358|CP137359|CP137360|CP137361|CP137351|CP137352|CP137353|CP137354|CP137355|CP137356|CP137413|CP137414|CP137415|CP137416|CP137417|CP137418|CP137419|CP137406|CP137407|CP137408|CP137409|CP137410|CP137411|CP137412|CP137391|CP137392|CP137393|CP137394|CP137395|CP138472|CP138473|CP138474|CP138475|CP138476|CP138477 | - |
| blaTEM-116 * | Reslit | 1 | beta lactams | Escherichia spp. | - | 2024 | - | - |
| bla(TEM-40) | Reslit | 1 | ceftazidime, ceftriaxone +1 | Klebsiella pneumoniae +1 | China | 2024 | CP109830.1|MN823985.1 | - |
| blaTEM-new (allele:99) | Reslit | 1 | penicillin | Neisseria gonorrhoeae | Guangdong, China | 2025 | NCBI: PRJNA123456 | - |
| blaTEM-new (allele:93) | Reslit | 1 | penicillin | Neisseria gonorrhoeae | Guangdong, China | 2025 | NCBI: PRJNA123456 | - |
| blaTEM-new (allele:7) | Reslit | 1 | penicillin | Neisseria gonorrhoeae | Guangdong, China | 2025 | NCBI: PRJNA123456 | - |
| blaTEM-new (allele:89) | Reslit | 1 | penicillin | Neisseria gonorrhoeae | Guangdong, China | 2025 | NCBI: PRJNA123456 | - |
| blaTEM-new (allele:94) | Reslit | 1 | penicillin | Neisseria gonorrhoeae | Guangdong, China | 2025 | NCBI: PRJNA123456 | - |
| blaTEM-new | Reslit | 1 | ceftriaxone | Neisseria gonorrhoeae | Guangdong, China | 2025 | NCBI: PRJNA123456 | - |
| bla_TEM-116 | Reslit | 1 | ampicillin | Escherichia coli | - | 2025 | - | - |
| blaTEM-58 | Reslit | 1 | beta lactams | Salmonella enterica subsp. enterica serovar Enteritidis | Hong Kong|mainland China|Australia|Canada|United States of America|South Africa|Taiwan|United Kingdom | 2025 | - | - |
| bla(TEM-176) | Reslit | 1 | cefotaxime, ceftazidime | Escherichia coli | China | 2024 | chr-EC012 (CP119577.1)|pEC012-1 (CP119578.1)|pEC012-2 (CP119579.2)|pEC012-3 (CP119580.2)|pEC012-4 (CP119581.2)|pEC012-5 (CP119582.2)|pEC012-6 (CP119583.2) | - |
| Tem | Reslit | 1 | ampicillin, amoxicillin +1 | Enterobacteriaceae | Jordan | 2025 | - | - |
| blaTEM-1&2 | Reslit | 1 | ampicillin | Klebsiella pneumoniae | Bangladesh | 2025 | - | - |
| blaTEM-1 R164S | Reslit | 1 | cefotaxime | Escherichia coli DH5alpha +1 | - | 2025 | - | - |
| blaTEM-1 G238S | Reslit | 1 | cefotaxime | Escherichia coli DH5alpha +1 | - | 2025 | - | - |
| blaTEM-45 | Card DatabaseReference Gene CatalogResFinder Database | 4 | TICARCILLIN, AMOXICILLIN +7 | Escherichia coli | - | 1997 | X95401 | CAA64682.1 |
| blaTEM-178 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +12 | Serratia marcescens | - | 1997 | X97254.1 | CAA65888.1 |
| blaTEM-49 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | ceftazidime, aztreonam +10 | Escherichia coli | Poland | 1998 | Y10279|Y10280|Y10281 | CAA71324.1 |
| blaTEM-60 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, TICARCILLIN +8 | Providencia stuartii | - | 1998 | AF047171.1 | AAC05975.1 |
Extended-spectrum beta-lactamase-producing Salmonella enteritidis in Trinidad and Tobago.
The study identifies a novel extended-spectrum beta-lactamase, blaTEM-27, responsible for resistance to penicillins and cephalosporins in a Salmonella enteritidis isolate from Trinidad and Tobago.
Sequences of the genes for the TEM-20, TEM-21, TEM-22, and TEM-29 extended-spectrum beta-lactamases.
Sequences of the genes for the TEM-20, TEM-21, TEM-22, and TEM-29 extended-spectrum beta-lactamases.
Sequences of the genes for the TEM-20, TEM-21, TEM-22, and TEM-29 extended-spectrum beta-lactamases.
Sequences of the genes for the TEM-20, TEM-21, TEM-22, and TEM-29 extended-spectrum beta-lactamases.
Survey of extended-spectrum beta-lactamases in clinical isolates of Escherichia coli and Klebsiella pneumoniae: prevalence of TEM-52 in Korea.
The study identifies TEM-52 as the most prevalent extended-spectrum beta-lactamase (ESBL) in clinical isolates of Escherichia coli and Klebsiella pneumoniae in Korea.
Molecular characterization of TEM-59 (IRT-17), a novel inhibitor-resistant TEM-derived beta-lactamase in a clinical isolate of Klebsiella oxytoca.
The study identifies TEM-59 (IRT-17), a novel inhibitor-resistant TEM-derived beta-lactamase in a clinical isolate of Klebsiella oxytoca, which shows resistance to penicillins and reduced susceptibility to beta-lactamase inhibitors.
Typing and characterization of mechanisms of resistance of Shigella spp. isolated from feces of children under 5 years of age from Ifakara, Tanzania.
The study identified blaOXA-1 and blaTEM-1 beta-lactamase genes responsible for ampicillin resistance in Shigella spp., and dhfrIa and dhfrVII genes associated with co-trimoxazole resistance.
Propagation of TEM- and PSE-type beta-lactamases among amoxicillin-resistant Salmonella spp. isolated in France.
The study identifies TEM-1 and PSE-1 beta-lactamases as the primary mechanisms of amoxicillin resistance in Salmonella spp. isolates in France, with PSE-1 being linked to a single epidemic strain.
Diversity of TEM Mutants in Proteus mirabilis.
The study characterizes several novel TEM-type β-lactamases in Proteus mirabilis, including TEM-57, TEM-66, TEM-65, TEM-73, and TEM-74, along with previously known variants such as TEM-1, TEM-2, TEM-3, TEM-24, and TEM-44. These enzymes exhibit varying degrees of resistance to β-lactam antibiotics, particularly amoxicillin, ticarcillin, piperacillin, and cephalothin, with some showing extended-spectrum activity against broader classes of β-lactams.
Diversity of TEM Mutants in Proteus mirabilis.
The study characterizes several novel TEM-type β-lactamases in Proteus mirabilis, including TEM-57, TEM-66, TEM-65, TEM-73, and TEM-74, along with previously known variants such as TEM-1, TEM-2, TEM-3, TEM-24, and TEM-44. These enzymes exhibit varying degrees of resistance to β-lactam antibiotics, particularly amoxicillin, ticarcillin, piperacillin, and cephalothin, with some showing extended-spectrum activity against broader classes of β-lactams.
Diversity of TEM Mutants in Proteus mirabilis.
The study characterizes several novel TEM-type β-lactamases in Proteus mirabilis, including TEM-57, TEM-66, TEM-65, TEM-73, and TEM-74, along with previously known variants such as TEM-1, TEM-2, TEM-3, TEM-24, and TEM-44. These enzymes exhibit varying degrees of resistance to β-lactam antibiotics, particularly amoxicillin, ticarcillin, piperacillin, and cephalothin, with some showing extended-spectrum activity against broader classes of β-lactams.
Diversity of TEM Mutants in Proteus mirabilis.
The study characterizes several novel TEM-type β-lactamases in Proteus mirabilis, including TEM-57, TEM-66, TEM-65, TEM-73, and TEM-74, along with previously known variants such as TEM-1, TEM-2, TEM-3, TEM-24, and TEM-44. These enzymes exhibit varying degrees of resistance to β-lactam antibiotics, particularly amoxicillin, ticarcillin, piperacillin, and cephalothin, with some showing extended-spectrum activity against broader classes of β-lactams.
Diversity of TEM Mutants in Proteus mirabilis.
The study characterizes several novel TEM-type β-lactamases in Proteus mirabilis, including TEM-57, TEM-66, TEM-65, TEM-73, and TEM-74, along with previously known variants such as TEM-1, TEM-2, TEM-3, TEM-24, and TEM-44. These enzymes exhibit varying degrees of resistance to β-lactam antibiotics, particularly amoxicillin, ticarcillin, piperacillin, and cephalothin, with some showing extended-spectrum activity against broader classes of β-lactams.
Diversity of TEM Mutants in Proteus mirabilis.
The study characterizes several novel TEM-type β-lactamases in Proteus mirabilis, including TEM-57, TEM-66, TEM-65, TEM-73, and TEM-74, along with previously known variants such as TEM-1, TEM-2, TEM-3, TEM-24, and TEM-44. These enzymes exhibit varying degrees of resistance to β-lactam antibiotics, particularly amoxicillin, ticarcillin, piperacillin, and cephalothin, with some showing extended-spectrum activity against broader classes of β-lactams.
Diversity of TEM Mutants in Proteus mirabilis.
The study characterizes several novel TEM-type β-lactamases in Proteus mirabilis, including TEM-57, TEM-66, TEM-65, TEM-73, and TEM-74, along with previously known variants such as TEM-1, TEM-2, TEM-3, TEM-24, and TEM-44. These enzymes exhibit varying degrees of resistance to β-lactam antibiotics, particularly amoxicillin, ticarcillin, piperacillin, and cephalothin, with some showing extended-spectrum activity against broader classes of β-lactams.
Diversity of TEM Mutants in Proteus mirabilis.
The study characterizes several novel TEM-type β-lactamases in Proteus mirabilis, including TEM-57, TEM-66, TEM-65, TEM-73, and TEM-74, along with previously known variants such as TEM-1, TEM-2, TEM-3, TEM-24, and TEM-44. These enzymes exhibit varying degrees of resistance to β-lactam antibiotics, particularly amoxicillin, ticarcillin, piperacillin, and cephalothin, with some showing extended-spectrum activity against broader classes of β-lactams.
Diversity of TEM Mutants in Proteus mirabilis.
The study characterizes several novel TEM-type β-lactamases in Proteus mirabilis, including TEM-57, TEM-66, TEM-65, TEM-73, and TEM-74, along with previously known variants such as TEM-1, TEM-2, TEM-3, TEM-24, and TEM-44. These enzymes exhibit varying degrees of resistance to β-lactam antibiotics, particularly amoxicillin, ticarcillin, piperacillin, and cephalothin, with some showing extended-spectrum activity against broader classes of β-lactams.
Diversity of TEM Mutants in Proteus mirabilis.
The study characterizes several novel TEM-type β-lactamases in Proteus mirabilis, including TEM-57, TEM-66, TEM-65, TEM-73, and TEM-74, along with previously known variants such as TEM-1, TEM-2, TEM-3, TEM-24, and TEM-44. These enzymes exhibit varying degrees of resistance to β-lactam antibiotics, particularly amoxicillin, ticarcillin, piperacillin, and cephalothin, with some showing extended-spectrum activity against broader classes of β-lactams.
Diversity of TEM mutants in Proteus mirabilis.
Diversity of TEM mutants in Proteus mirabilis.
Diversity of TEM mutants in Proteus mirabilis.
Diversity of TEM mutants in Proteus mirabilis.
Diversity of TEM mutants in Proteus mirabilis.
Diversity of TEM mutants in Proteus mirabilis.
Bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a pediatric oncology ward: clinical features and identification of different plasmids carrying both SHV-5 and TEM-1 genes.
The study identifies SHV-5 and TEM-1 beta-lactamase genes in extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates from a pediatric oncology ward, highlighting their role in resistance to various beta-lactam antibiotics.
Complete sequence of a beta-lactamase-encoding plasmid in Neisseria meningitidis.
The study reports the complete sequence of a beta-lactamase-encoding plasmid (pAB6) from two clinical Neisseria meningitidis strains, identifying the TEM-1 beta-lactamase gene as responsible for penicillin resistance.
Capnocytophaga ochracea: characterization of a plasmid-encoded extended-spectrum TEM-17 beta-lactamase in the phylum Flavobacter-bacteroides.
The study identified a plasmid-encoded extended-spectrum beta-lactamase, TEM-17, in Capnocytophaga ochracea, which confers resistance to various beta-lactam antibiotics.
Capnocytophaga ochracea: characterization of a plasmid-encoded extended-spectrum TEM-17 beta-lactamase in the phylum Flavobacter-bacteroides.
Capnocytophaga ochracea: characterization of a plasmid-encoded extended-spectrum TEM-17 beta-lactamase in the phylum Flavobacter-bacteroides.
Capnocytophaga ochracea: characterization of a plasmid-encoded extended-spectrum TEM-17 beta-lactamase in the phylum Flavobacter-bacteroides.
Capnocytophaga ochracea: characterization of a plasmid-encoded extended-spectrum TEM-17 beta-lactamase in the phylum Flavobacter-bacteroides.
A novel complex mutant beta-lactamase, TEM-68, identified in a Klebsiella pneumoniae isolate from an outbreak of extended-spectrum beta-lactamase-producing Klebsiellae.
The study identifies TEM-68, a novel complex mutant beta-lactamase in a Klebsiella pneumoniae isolate, which exhibits both extended-spectrum beta-lactamase (ESBL) and inhibitor resistance (IR) activities.
A novel complex mutant beta-lactamase, TEM-68, identified in a Klebsiella pneumoniae isolate from an outbreak of extended-spectrum beta-lactamase-producing Klebsiellae.
A novel complex mutant beta-lactamase, TEM-68, identified in a Klebsiella pneumoniae isolate from an outbreak of extended-spectrum beta-lactamase-producing Klebsiellae.
A novel complex mutant beta-lactamase, TEM-68, identified in a Klebsiella pneumoniae isolate from an outbreak of extended-spectrum beta-lactamase-producing Klebsiellae.
A novel complex mutant beta-lactamase, TEM-68, identified in a Klebsiella pneumoniae isolate from an outbreak of extended-spectrum beta-lactamase-producing Klebsiellae.
Prevalence of beta-lactamases among 1,072 clinical strains of Proteus mirabilis: a 2-year survey in a French hospital.
The study identified various beta-lactamase genes including TEM-1, TEM-2, TEM-3, TEM-66, CARB-2, SHV-1, IRT-13, IRT-16, and IRT-2 in Proteus mirabilis strains, highlighting their role in beta-lactam resistance.
Prevalence of beta-lactamases among 1,072 clinical strains of Proteus mirabilis: a 2-year survey in a French hospital.
The study identified various beta-lactamase genes including TEM-1, TEM-2, TEM-3, TEM-66, CARB-2, SHV-1, IRT-13, IRT-16, and IRT-2 in Proteus mirabilis strains, highlighting their role in beta-lactam resistance.
Prevalence of beta-lactamases among 1,072 clinical strains of Proteus mirabilis: a 2-year survey in a French hospital.
The study identified various beta-lactamase genes including TEM-1, TEM-2, TEM-3, TEM-66, CARB-2, SHV-1, IRT-13, IRT-16, and IRT-2 in Proteus mirabilis strains, highlighting their role in beta-lactam resistance.
Prevalence of beta-lactamases among 1,072 clinical strains of Proteus mirabilis: a 2-year survey in a French hospital.
The study identified various beta-lactamase genes including TEM-1, TEM-2, TEM-3, TEM-66, CARB-2, SHV-1, IRT-13, IRT-16, and IRT-2 in Proteus mirabilis strains, highlighting their role in beta-lactam resistance.
Concentration-Dependent Selection of Small Phenotypic Differences in TEM β-Lactamase-Mediated Antibiotic Resistance.
The study identifies TEM-1 and TEM-12 beta-lactamases as key players in antibiotic resistance, demonstrating that small phenotypic differences in these enzymes can lead to significant resistance variations depending on antibiotic concentration.
Concentration-Dependent Selection of Small Phenotypic Differences in TEM β-Lactamase-Mediated Antibiotic Resistance.
The study identifies TEM-1 and TEM-12 beta-lactamases as key players in antibiotic resistance, demonstrating that small phenotypic differences in these enzymes can lead to significant resistance variations depending on antibiotic concentration.
TEM-72, a new extended-spectrum beta-lactamase detected in Proteus mirabilis and Morganella morganii in Italy.
The study identifies TEM-72, a new extended-spectrum beta-lactamase in Proteus mirabilis and Morganella morganii, which confers resistance to various beta-lactam antibiotics.
TEM-72, a new extended-spectrum beta-lactamase detected in Proteus mirabilis and Morganella morganii in Italy.
TEM-72, a new extended-spectrum beta-lactamase detected in Proteus mirabilis and Morganella morganii in Italy.
TEM-72, a new extended-spectrum beta-lactamase detected in Proteus mirabilis and Morganella morganii in Italy.
TEM-72, a new extended-spectrum beta-lactamase detected in Proteus mirabilis and Morganella morganii in Italy.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of blaTEM genes.
The study identified new genetic features of blaTEM genes in amoxicillin-clavulanate-resistant Escherichia coli isolates, including novel mutations and promoter variations that contribute to resistance.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of blaTEM genes.
The study identified new genetic features of blaTEM genes in amoxicillin-clavulanate-resistant Escherichia coli isolates, including novel mutations and promoter variations that contribute to resistance.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of blaTEM genes.
The study identified new genetic features of blaTEM genes in amoxicillin-clavulanate-resistant Escherichia coli isolates, including novel mutations and promoter variations that contribute to resistance.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of blaTEM genes.
The study identified new genetic features of blaTEM genes in amoxicillin-clavulanate-resistant Escherichia coli isolates, including novel mutations and promoter variations that contribute to resistance.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of blaTEM genes.
The study identified new genetic features of blaTEM genes in amoxicillin-clavulanate-resistant Escherichia coli isolates, including novel mutations and promoter variations that contribute to resistance.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.
Analytical isoelectric focusing of R factor-determined beta-lactamases: correlation with plasmid compatibility.
Analytical isoelectric focusing of R factor-determined beta-lactamases: correlation with plasmid compatibility.
Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum beta-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla TEM-53, bla TEM-63, and novel bla SHV variants (SHV-19 to SHV-22), in Klebsiella pneumoniae isolates from a South African hospital.
Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum beta-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla TEM-53, bla TEM-63, and novel bla SHV variants (SHV-19 to SHV-22), in Klebsiella pneumoniae isolates from a South African hospital.
Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum beta-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa.
Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum beta-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa.
Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum beta-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa.
Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum beta-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa.
SHV-14, a novel beta-lactamase variant in Klebsiella pneumoniae isolates from Nijmegen, The Netherlands.
The study identifies SHV-14, a novel beta-lactamase variant in Klebsiella pneumoniae isolates, and TEM-29, a known extended-spectrum beta-lactamase, as contributors to beta-lactam resistance.
New TEM variant (TEM-92) produced by Proteus mirabilis and Providencia stuartii isolates.
The study identifies a new TEM variant, TEM-92, produced by Proteus mirabilis and Providencia stuartii isolates, which exhibits resistance to ceftazidime and cefotaxime.
New TEM variant (TEM-92) produced by Proteus mirabilis and Providencia stuartii isolates.
New TEM variant (TEM-92) produced by Proteus mirabilis and Providencia stuartii isolates.
New TEM variant (TEM-92) produced by Proteus mirabilis and Providencia stuartii isolates.
Coexistence of SHV-4- and TEM-24-producing Enterobacter aerogenes strains before a large outbreak of TEM-24-producing strains in a French hospital.
The study identifies the presence of SHV-4 and TEM-24 extended-spectrum beta-lactamase-producing Enterobacter aerogenes strains in a French hospital before a large outbreak of TEM-24-producing strains. Both genes were experimentally validated for their resistance mechanisms.
Large drug resistance virulence plasmids of clinical isolates of Salmonella enterica serovar Choleraesuis.
The study identifies the presence of drug resistance genes sulII, bla TEM-1, and sulI on large virulence plasmids of Salmonella enterica serovar Choleraesuis, highlighting their role in multidrug resistance.
Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae.
The study identifies a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae. IMP-8 differs from IMP-2 by four nucleotide substitutions leading to two amino acid changes and is carried on an integron-borne gene cassette.
Diversity of SHV and TEM beta-lactamases in Klebsiella pneumoniae: gene evolution in Northern Taiwan and two novel beta-lactamases, SHV-25 and SHV-26.
The study identifies two novel beta-lactamases, SHV-25 and SHV-26, in Klebsiella pneumoniae isolates from northern Taiwan. SHV-25 is a non-ESBL, while SHV-26 exhibits reduced susceptibility to clavulanic acid.
Sequences of the NPS-1 and TLE-1 beta-lactamase genes.
Sequences of the NPS-1 and TLE-1 beta-lactamase genes.
Sequences of the NPS-1 and TLE-1 beta-lactamase genes.
Sequences of the NPS-1 and TLE-1 beta-lactamase genes.
Evolution of TEM-related extended-spectrum beta-lactamases in Korea.
The study characterizes the novel TEM-type ESBL TEM-88 and compares its biochemical characteristics to those of TEM-15 and TEM-52, identifying their resistance profiles against various beta-lactam antibiotics.
Evolution of TEM-related extended-spectrum beta-lactamases in Korea.
The study characterizes the novel TEM-type ESBL TEM-88 and compares its biochemical characteristics to those of TEM-15 and TEM-52, identifying their resistance profiles against various beta-lactam antibiotics.
Evolution of TEM-related extended-spectrum beta-lactamases in Korea.
The study characterizes the novel TEM-type ESBL TEM-88 and compares its biochemical characteristics to those of TEM-15 and TEM-52, identifying their resistance profiles against various beta-lactam antibiotics.
Evolution of TEM-related extended-spectrum beta-lactamases in Korea.
Evolution of TEM-related extended-spectrum beta-lactamases in Korea.
Evolution of TEM-related extended-spectrum beta-lactamases in Korea.
Evolution of TEM-related extended-spectrum beta-lactamases in Korea.
Genes encoding TEM-4, SHV-2, and CTX-M-10 extended-spectrum beta-lactamases are carried by multiple Klebsiella pneumoniae clones in a single hospital (Madrid, 1989 to 2000).
The study identifies multiple Klebsiella pneumoniae clones carrying TEM-4, SHV-2, SHV-2a, SHV-5, CTX-M-10, and CTX-M-9 extended-spectrum beta-lactamases, highlighting the clonal diversity and spread of these resistance genes in a single hospital over a 12-year period.
Characterization of a new extended-spectrum beta-lactamase (TEM-87) isolated in Proteus mirabilis during an Italian survey.
The study identifies TEM-87, a new extended-spectrum beta-lactamase in Proteus mirabilis, which shows resistance to ceftazidime, aztreonam, and oxyimino cephalosporins.
Characterization of a new extended-spectrum beta-lactamase (TEM-87) isolated in Proteus mirabilis during an Italian survey.
Characterization of a new extended-spectrum beta-lactamase (TEM-87) isolated in Proteus mirabilis during an Italian survey.
Characterization of a new extended-spectrum beta-lactamase (TEM-87) isolated in Proteus mirabilis during an Italian survey.
Characterization of a new extended-spectrum beta-lactamase (TEM-87) isolated in Proteus mirabilis during an Italian survey.
Epidemiology of extended-spectrum beta-lactamase-producing Enterobacter isolates in a Spanish hospital during a 12-year period.
The study identified three distinct extended-spectrum beta-lactamases (ESBLs): CTX-M-10, TEM-24, and TEM-27, which were responsible for resistance to extended-spectrum cephalosporins in Enterobacter isolates.
Epidemiology of extended-spectrum beta-lactamase-producing Enterobacter isolates in a Spanish hospital during a 12-year period.
The study identified three distinct extended-spectrum beta-lactamases (ESBLs): CTX-M-10, TEM-24, and TEM-27, which were responsible for resistance to extended-spectrum cephalosporins in Enterobacter isolates.
TEM-80, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Enterobacter cloacae.
The study identifies TEM-80, a novel inhibitor-resistant beta-lactamase in clinical isolates of Enterobacter cloacae and Escherichia coli, which confers resistance to ampicillin, amoxicillin, ticarcillin, and cephalothin.
TEM-80, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Enterobacter cloacae.
TEM-80, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Enterobacter cloacae.
TEM-80, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Enterobacter cloacae.
TEM-80, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Enterobacter cloacae.
Bloodstream Infections by Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae in Children: Epidemiology and Clinical Outcome.
The study identifies several extended-spectrum beta-lactamases (ESBLs) including TEM-52, SHV-2a, TEM-88, CMY-1-like, and CTX-M-14 in Escherichia coli and Klebsiella pneumoniae isolates from children with bloodstream infections. These ESBLs confer resistance to various beta-lactam antibiotics.
Bloodstream Infections by Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae in Children: Epidemiology and Clinical Outcome.
The study identifies several extended-spectrum beta-lactamases (ESBLs) including TEM-52, SHV-2a, TEM-88, CMY-1-like, and CTX-M-14 in Escherichia coli and Klebsiella pneumoniae isolates from children with bloodstream infections. These ESBLs confer resistance to various beta-lactam antibiotics.
Bloodstream infections by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in children: epidemiology and clinical outcome.
Bloodstream infections by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in children: epidemiology and clinical outcome.
Bloodstream infections by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in children: epidemiology and clinical outcome.
Bloodstream infections by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in children: epidemiology and clinical outcome.
Bloodstream infections by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in children: epidemiology and clinical outcome.
Bloodstream infections by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in children: epidemiology and clinical outcome.
TEM-71, a novel plasmid-encoded, extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae.
The study identifies TEM-71, a novel plasmid-encoded extended-spectrum beta-lactamase from a clinical isolate of Klebsiella pneumoniae, which exhibits resistance to multiple beta-lactam antibiotics including ceftazidime, cefotaxime, and aztreonam.
TEM-71, a novel plasmid-encoded, extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae.
TEM-71, a novel plasmid-encoded, extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae.
TEM-71, a novel plasmid-encoded, extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae.
TEM-71, a novel plasmid-encoded, extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae.
Novel plasmid-encoded class C beta-lactamase (MOX-2) in Klebsiella pneumoniae from Greece.
The study identifies a novel plasmid-encoded class C beta-lactamase, MOX-2, in a multidrug-resistant Klebsiella pneumoniae isolate from Greece, which exhibits high hydrolytic activity against various beta-lactam antibiotics.
The resistance mechanisms of b-lactam antimicrobials in clinical isolates of Acinetobacter baumannii.
The study identified blaTEM-1 and blaPER-1 beta-lactamase genes as contributors to beta-lactam resistance in Acinetobacter baumannii. The chromosomal AmpC beta-lactamase was found to play a significant role in resistance, while changes in outer membrane proteins were linked to carbapenem resistance.
Novel ceftazidime-resistance beta-lactamases generated by a codon-based mutagenesis method and selection.
Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.
The study identifies various TEM-type beta-lactamase genes, including novel variants such as bla TEM-95b, which confers resistance to ampicillin and ticarcillin in Escherichia coli isolates from diverse sources.
Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.
The study identifies various TEM-type beta-lactamase genes, including novel variants such as bla TEM-95b, which confers resistance to ampicillin and ticarcillin in Escherichia coli isolates from diverse sources.
Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.
The study identifies various TEM-type beta-lactamase genes, including novel variants such as bla TEM-95b, which confers resistance to ampicillin and ticarcillin in Escherichia coli isolates from diverse sources.
Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.
The study identifies various TEM-type beta-lactamase genes, including novel variants such as bla TEM-95b, which confers resistance to ampicillin and ticarcillin in Escherichia coli isolates from diverse sources.
Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.
The study identifies various TEM-type beta-lactamase genes, including novel variants such as bla TEM-95b, which confers resistance to ampicillin and ticarcillin in Escherichia coli isolates from diverse sources.
Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.
The study identifies various TEM-type beta-lactamase genes, including novel variants such as bla TEM-95b, which confers resistance to ampicillin and ticarcillin in Escherichia coli isolates from diverse sources.
Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.
The study identifies various TEM-type beta-lactamase genes, including novel variants such as bla TEM-95b, which confers resistance to ampicillin and ticarcillin in Escherichia coli isolates from diverse sources.
Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.
The study identifies various TEM-type beta-lactamase genes, including novel variants such as bla TEM-95b, which confers resistance to ampicillin and ticarcillin in Escherichia coli isolates from diverse sources.
Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.
The study identifies various TEM-type beta-lactamase genes, including novel variants such as bla TEM-95b, which confers resistance to ampicillin and ticarcillin in Escherichia coli isolates from diverse sources.
Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.
The study identifies various TEM-type beta-lactamase genes, including novel variants such as bla TEM-95b, which confers resistance to ampicillin and ticarcillin in Escherichia coli isolates from diverse sources.
Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.
Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.
Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.
Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals.
TEM-103/IRT-28 beta-lactamase, a new TEM variant produced by Escherichia coli BM4511.
The study identifies a new TEM variant, TEM-103/IRT-28, which confers resistance to penicillins and is resistant to β-lactamase inhibitors due to the Arg 275 Leu substitution.
TEM-103/IRT-28 beta-lactamase, a new TEM variant produced by Escherichia coli BM4511.
TEM-103/IRT-28 beta-lactamase, a new TEM variant produced by Escherichia coli BM4511.
Phenotype and molecular characterization of the first inhibitor-resistant TEM-derived beta-lactamase identified in Portugal.
The study reports the first inhibitor-resistant TEM-derived beta-lactamase (TEM-30, IRT-2) identified in Portugal, which shows resistance to amoxicillin and ticarcillin, and a nucleotide substitution (C929→A) leading to Arg244→Ser amino acid change.
Phenotype and molecular characterization of the first inhibitor-resistant TEM-derived beta-lactamase identified in Portugal.
Distribution of extended-spectrum beta-lactamases in clinical isolates of Enterobacteriaceae in Vietnam.
The study identified several extended-spectrum beta-lactamases, including bla TEM-1, bla SHV-2, bla VEB-1, bla CTX-M-14, and bla CTX-M-17, which confer resistance to various cephalosporins in Enterobacteriaceae isolates from Vietnam.
Mechanisms of decreased susceptibility to cefpodoxime in Escherichia coli.
The study identified blaTEM-1 and blaOXA-30 as the primary genes responsible for decreased susceptibility to cefpodoxime in E. coli, with additional contributions from porin alterations.
A multiresistant clone of Shiga toxin-producing Escherichia coli O118:[H16] is spread in cattle and humans over different European countries.
Integration of a transposon Tn1-encoded inhibitor-resistant beta-lactamase gene, blaTEM-67 from Proteus mirabilis, into the Escherichia coli chromosome.
The study identifies blaTEM-67, a novel inhibitor-resistant beta-lactamase gene from Proteus mirabilis, which was integrated into the Escherichia coli chromosome. This gene confers resistance to amoxicillin and amoxicillin-clavulanic acid.
Integration of a transposon Tn1-encoded inhibitor-resistant beta-lactamase gene, bla(TEM-67) from Proteus mirabilis, into the Escherichia coli chromosome.
Integration of a transposon Tn1-encoded inhibitor-resistant beta-lactamase gene, bla(TEM-67) from Proteus mirabilis, into the Escherichia coli chromosome.
Integration of a transposon Tn1-encoded inhibitor-resistant beta-lactamase gene, bla(TEM-67) from Proteus mirabilis, into the Escherichia coli chromosome.
Integration of a transposon Tn1-encoded inhibitor-resistant beta-lactamase gene, bla(TEM-67) from Proteus mirabilis, into the Escherichia coli chromosome.
In34, a complex In5 family class 1 integron containing orf513 and dfrA10.
The study identifies and characterizes the class 1 integron In34, which contains multiple antibiotic resistance genes including aadB, dfrA10, aphA1, catA1, blaTEM, and sul1. These genes confer resistance to various antibiotics such as gentamicin, kanamycin, tobramycin, trimethoprim, chloramphenicol, ampicillin, and sulfamethoxazole.
Characterization of clinical isolates of Enterobacteriaceae from Italy by the BD Phoenix extended-spectrum beta-lactamase detection method.
The study characterized ESBL-producing Enterobacteriaceae isolates from Italy, identifying bla TEM-1, bla SHV-1, and bla CTX-M genes as the primary resistance mechanisms against extended-spectrum cephalosporins.
Haemophilus influenzae Carriage in Children Attending French Day Care Centers: a Molecular Epidemiological Study.
The study identified TEM-type beta-lactamase-producing Haemophilus influenzae strains, which confer resistance to ampicillin.
Molecular epidemiology and characterization of plasmid-encoded beta-lactamases produced by Tunisian clinical isolates of Salmonella enterica serotype Mbandaka resistant to broad-spectrum cephalosporins.
The study identified plasmid-encoded beta-lactamases TEM-4, SHV-2a, and ACC-1a in Salmonella enterica serotype Mbandaka isolates resistant to broad-spectrum cephalosporins.
Extended-spectrum beta-lactamases in Ireland, including a novel enzyme, TEM-102.
Extended-spectrum beta-lactamases in Ireland, including a novel enzyme, TEM-102.
Extended-spectrum beta-lactamases in Ireland, including a novel enzyme, TEM-102.
A new TEM-derived extended-spectrum beta-lactamase (TEM-91) with an R164C substitution at the omega-loop confers ceftazidime resistance.
The study identifies a new TEM-derived extended-spectrum beta-lactamase, TEM-91, which confers resistance to ceftazidime through specific amino acid substitutions.
A new TEM-derived extended-spectrum beta-lactamase (TEM-91) with an R164C substitution at the omega-loop confers ceftazidime resistance.
A new TEM-derived extended-spectrum beta-lactamase (TEM-91) with an R164C substitution at the omega-loop confers ceftazidime resistance.
A new TEM-derived extended-spectrum beta-lactamase (TEM-91) with an R164C substitution at the omega-loop confers ceftazidime resistance.
A new TEM-derived extended-spectrum beta-lactamase (TEM-91) with an R164C substitution at the omega-loop confers ceftazidime resistance.
Transposition of the gene encoding a TEM-12 extended-spectrum beta-lactamase.
A new example of physical linkage between Tn1 and Tn21: the antibiotic multiple-resistance region of plasmid pCFF04 encoding extended-spectrum beta-lactamase TEM-3.
Nucleotide sequences of CAZ-2, CAZ-6, and CAZ-7 beta-lactamase genes.
Nucleotide sequences of CAZ-2, CAZ-6, and CAZ-7 beta-lactamase genes.
Outbreak of ceftazidime resistance due to a novel extended-spectrum beta-lactamase in isolates from cancer patients.
A novel extended-spectrum beta-lactamase, TEM-26, was identified as the cause of ceftazidime resistance in isolates from cancer patients. This enzyme hydrolyzes ceftazidime, aztreonam, and penicillins.
Outbreak of ceftazidime resistance due to a novel extended-spectrum beta-lactamase in isolates from cancer patients.
Outbreak of ceftazidime resistance due to a novel extended-spectrum beta-lactamase in isolates from cancer patients.
Outbreak of ceftazidime resistance due to a novel extended-spectrum beta-lactamase in isolates from cancer patients.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae in community and private health care centers.
The study identifies various extended-spectrum beta-lactamases (ESBLs) including TEM-24b, TEM-21, TEM-15, TEM-19, TEM-3, SHV-4, and CTX-M-1, which confer resistance to multiple beta-lactam antibiotics in Enterobacteriaceae isolates from community and private healthcare centers.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae in community and private health care centers.
The study identifies various extended-spectrum beta-lactamases (ESBLs) including TEM-24b, TEM-21, TEM-15, TEM-19, TEM-3, SHV-4, and CTX-M-1, which confer resistance to multiple beta-lactam antibiotics in Enterobacteriaceae isolates from community and private healthcare centers.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae in community and private health care centers.
The study identifies various extended-spectrum beta-lactamases (ESBLs) including TEM-24b, TEM-21, TEM-15, TEM-19, TEM-3, SHV-4, and CTX-M-1, which confer resistance to multiple beta-lactam antibiotics in Enterobacteriaceae isolates from community and private healthcare centers.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae in community and private health care centers.
The study identifies various extended-spectrum beta-lactamases (ESBLs) including TEM-24b, TEM-21, TEM-15, TEM-19, TEM-3, SHV-4, and CTX-M-1, which confer resistance to multiple beta-lactam antibiotics in Enterobacteriaceae isolates from community and private healthcare centers.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae in community and private health care centers.
The study identifies various extended-spectrum beta-lactamases (ESBLs) including TEM-24b, TEM-21, TEM-15, TEM-19, TEM-3, SHV-4, and CTX-M-1, which confer resistance to multiple beta-lactam antibiotics in Enterobacteriaceae isolates from community and private healthcare centers.
Extended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamases.
The study identified SHV- and CTX-M-type extended-spectrum beta-lactamases as the most prevalent in Klebsiella pneumoniae bloodstream isolates from seven countries, highlighting their significance in antibiotic resistance.
Cephalosporin-resistant Escherichia coli among summer camp attendees with salmonellosis.
The study identified CTX-M-9, CMY-2, and TEM-1 beta-lactamase genes in extended-spectrum cephalosporin-resistant Escherichia coli (ESCREC) isolates from a summer camp outbreak. These genes conferred resistance to various β-lactam antibiotics.
Epidemiology of nalidixic acid resistance and TEM-1- and TEM-52-mediated ampicillin resistance of Shigella sonnei isolates obtained in Korea between 1980 and 2000.
The study identified TEM-1 and TEM-52 beta-lactamases as mediators of ampicillin resistance in Shigella sonnei isolates, and a single point mutation in gyrA (Ser83→Leu) as the mechanism of nalidixic acid resistance.
Epidemiology of nalidixic acid resistance and TEM-1- and TEM-52-mediated ampicillin resistance of Shigella sonnei isolates obtained in Korea between 1980 and 2000.
The study identified TEM-1 and TEM-52 beta-lactamases as mediators of ampicillin resistance in Shigella sonnei isolates, and a single point mutation in gyrA (Ser83→Leu) as the mechanism of nalidixic acid resistance.
Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae.
The study identifies two novel oxacillinases, OXA-48 and OXA-47, which confer resistance to imipenem and ceftazidime, respectively, in a multidrug-resistant Klebsiella pneumoniae isolate.
Utility of NCCLS guidelines for identifying extended-spectrum beta-lactamases in non-Escherichia coli and non-Klebsiella spp. of Enterobacteriaceae.
The study evaluated the effectiveness of NCCLS guidelines for detecting extended-spectrum beta-lactamases (ESBLs) in non-E. coli and non-Klebsiella spp. of Enterobacteriaceae. It found that only a small percentage of isolates showed a CA effect, and only a few isolates had ESBL genes such as bla TEM and bla SHV.
Clinical isolates of Escherichia coli producing TRI beta-lactamases: novel TEM-enzymes conferring resistance to beta-lactamase inhibitors.
Clinical isolates of Escherichia coli producing TRI beta-lactamases: novel TEM-enzymes conferring resistance to beta-lactamase inhibitors.
Clinical isolates of Escherichia coli producing TRI beta-lactamases: novel TEM-enzymes conferring resistance to beta-lactamase inhibitors.
Clinical isolates of Escherichia coli producing TRI beta-lactamases: novel TEM-enzymes conferring resistance to beta-lactamase inhibitors.
Clinical isolates of Escherichia coli producing TRI beta-lactamases: novel TEM-enzymes conferring resistance to beta-lactamase inhibitors.
Epidemiology and clinical features of infections caused by extended-spectrum beta-lactamase-producing Escherichia coli in nonhospitalized patients.
The study identifies CTX-M-9, TEM, and SHV extended-spectrum beta-lactamases as major contributors to antimicrobial resistance in Escherichia coli isolates from nonhospitalized patients.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Canadian hospitals, including novel variants such as TEM-115, TEM-120, SHV-40, SHV-41, and SHV-42, highlighting the diversity and emergence of these resistance mechanisms in Escherichia coli and Klebsiella spp.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Canadian hospitals, including novel variants such as TEM-115, TEM-120, SHV-40, SHV-41, and SHV-42, highlighting the diversity and emergence of these resistance mechanisms in Escherichia coli and Klebsiella spp.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Canadian hospitals, including novel variants such as TEM-115, TEM-120, SHV-40, SHV-41, and SHV-42, highlighting the diversity and emergence of these resistance mechanisms in Escherichia coli and Klebsiella spp.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Canadian hospitals, including novel variants such as TEM-115, TEM-120, SHV-40, SHV-41, and SHV-42, highlighting the diversity and emergence of these resistance mechanisms in Escherichia coli and Klebsiella spp.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Canadian hospitals, including novel variants such as TEM-115, TEM-120, SHV-40, SHV-41, and SHV-42, highlighting the diversity and emergence of these resistance mechanisms in Escherichia coli and Klebsiella spp.
Ambler Class A Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella spp. in Canadian Hospitals
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Canadian hospitals, including novel variants such as TEM-115, TEM-120, SHV-40, SHV-41, and SHV-42, highlighting the diversity and emergence of these resistance mechanisms in Escherichia coli and Klebsiella spp.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitals.
Variety of beta-lactamases produced by amoxicillin-clavulanate-resistant Escherichia coli isolated in the northeastern United States.
The study identified various beta-lactamases, including TEM-type, CMY-2, and OXA-type, in amoxicillin-clavulanate-resistant Escherichia coli isolates. Notably, two isolates harbored inhibitor-resistant TEM enzymes (TEM-34 and TEM-122) that conferred resistance to amoxicillin-clavulanate.
Variety of beta-lactamases produced by amoxicillin-clavulanate-resistant Escherichia coli isolated in the northeastern United States.
Variety of beta-lactamases produced by amoxicillin-clavulanate-resistant Escherichia coli isolated in the northeastern United States.
Variety of beta-lactamases produced by amoxicillin-clavulanate-resistant Escherichia coli isolated in the northeastern United States.
Variety of beta-lactamases produced by amoxicillin-clavulanate-resistant Escherichia coli isolated in the northeastern United States.
SHV-12-Like Extended-Spectrum-β-Lactamase-Producing Strains of Salmonella enterica Serotypes Babelsberg and Enteritidis Isolated in France among Infants Adopted from Mali.
The study identifies SHV-12-like extended-spectrum beta-lactamase-producing strains of Salmonella enterica serotypes Babelsberg and Enteritidis isolated in France among infants adopted from Mali. The SHV-12 beta-lactamase was found to confer resistance to cephalosporins, while TEM beta-lactamase conferred resistance to penicillins and cephalosporins.
Antibacterial resistance, Wayampis Amerindians, French Guyana.
The study identified blaTEM-52, an extended-spectrum beta-lactamase gene, in Escherichia coli isolates from Wayampis Amerindians in French Guyana, indicating community transmission of hospital-associated resistance mechanisms despite limited antibacterial use.
Molecular characterization of extended-spectrum beta-lactamases produced by clinical isolates of Klebsiella pneumoniae and Escherichia coli from a Korean nationwide survey.
Molecular characterization of extended-spectrum beta-lactamases produced by clinical isolates of Klebsiella pneumoniae and Escherichia coli from a Korean nationwide survey.
Molecular characterization of extended-spectrum beta-lactamases produced by clinical isolates of Klebsiella pneumoniae and Escherichia coli from a Korean nationwide survey.
Molecular characterization of extended-spectrum beta-lactamases produced by clinical isolates of Klebsiella pneumoniae and Escherichia coli from a Korean nationwide survey.
Molecular Epidemiology of Serratia marcescens in Two Hospitals in Danzig, Poland, over a 5-Year Period
The study identified CTX-M-3, TEM-47, and SHV-5 extended-spectrum beta-lactamases in Serratia marcescens isolates from two hospitals in Danzig, Poland, over a 5-year period. These enzymes conferred resistance to various beta-lactam antibiotics.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study.
Use of DNA microarrays for rapid genotyping of TEM beta-lactamases that confer resistance.
The study describes a DNA microarray for the rapid genotyping of TEM beta-lactamases, enabling the identification of single nucleotide polymorphisms (SNPs) in 96% of the TEM beta-lactamase variants related to extended-spectrum beta-lactamase (ESBL) and inhibitor-resistant TEM (IRT) phenotypes.
Use of DNA microarrays for rapid genotyping of TEM beta-lactamases that confer resistance.
Use of DNA microarrays for rapid genotyping of TEM beta-lactamases that confer resistance.
Use of DNA microarrays for rapid genotyping of TEM beta-lactamases that confer resistance.
Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada.
The study reports the complete nucleotide sequence of a 92-kilobase plasmid, pC15-1a, which harbors the CTX-M-15 extended-spectrum beta-lactamase, along with other resistance genes such as blaOXA-1, blaTEM-1, aac(6')-Ib, aac(3)-II, and tetA. These genes contribute to multidrug resistance in Escherichia coli strains associated with an outbreak in long-term-care facilities in Toronto, Canada.
Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada.
Outbreak of multi-resistant Klebsiella oxytoca involving strains with extended-spectrum beta-lactamases and strains with extended-spectrum activity of the chromosomal beta-lactamase.
Outbreak of multi-resistant Klebsiella oxytoca involving strains with extended-spectrum beta-lactamases and strains with extended-spectrum activity of the chromosomal beta-lactamase.
Outbreak of multi-resistant Klebsiella oxytoca involving strains with extended-spectrum beta-lactamases and strains with extended-spectrum activity of the chromosomal beta-lactamase.
Outbreak of multi-resistant Klebsiella oxytoca involving strains with extended-spectrum beta-lactamases and strains with extended-spectrum activity of the chromosomal beta-lactamase.
Pediatric infection due to multiresistant Salmonella enterica serotype Infantis in Honduras.
The study reports the first detection of bla CTX-M-15 in Salmonella and identifies multiple beta-lactamase genes (bla TEM-1b, bla SHV-5, bla CTX-M-15, and bla CMY-2) in a multidrug-resistant Salmonella enterica serotype Infantis isolate from Honduras.
CTX-M beta-lactamase-producing Escherichia coli in long-term care facilities, France.
The study reports the first documented outbreak of CTX-M-producing E. coli in a long-term care facility in France, highlighting the emergence of these strains and their resistance mechanisms.
Emergence of multidrug-resistant Salmonella enterica serovar typhi in Korea.
The study identified the TEM-1 beta-lactamase as a key contributor to ampicillin resistance in multidrug-resistant Salmonella enterica serovar Typhi strains in Korea.
Infections with nontyphoidal Salmonella species producing TEM-63 or a novel TEM enzyme, TEM-131, in South Africa.
The study identifies TEM-63 and a novel TEM enzyme, TEM-131, in nontyphoidal Salmonella isolates from South Africa, highlighting their role in resistance to extended-spectrum cephalosporins.
Infections with nontyphoidal Salmonella species producing TEM-63 or a novel TEM enzyme, TEM-131, in South Africa.
The study identifies TEM-63 and a novel TEM enzyme, TEM-131, in nontyphoidal Salmonella isolates from South Africa, highlighting their role in resistance to extended-spectrum cephalosporins.
Infections with nontyphoidal Salmonella species producing TEM-63 or a novel TEM enzyme, TEM-131, in South Africa.
Infections with nontyphoidal Salmonella species producing TEM-63 or a novel TEM enzyme, TEM-131, in South Africa.
Infections with nontyphoidal Salmonella species producing TEM-63 or a novel TEM enzyme, TEM-131, in South Africa.
Infections with nontyphoidal Salmonella species producing TEM-63 or a novel TEM enzyme, TEM-131, in South Africa.
Occurrence of extended-spectrum beta-lactamases in members of the genus Shigella in the Republic of Korea.
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Shigella sonnei isolates from South Korea, including TEM-15, TEM-17, TEM-19, TEM-20, TEM-52, and CTX-M-14, which confer resistance to ceftazidime and cefotaxime.
Occurrence of extended-spectrum beta-lactamases in members of the genus Shigella in the Republic of Korea.
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Shigella sonnei isolates from South Korea, including TEM-15, TEM-17, TEM-19, TEM-20, TEM-52, and CTX-M-14, which confer resistance to ceftazidime and cefotaxime.
Occurrence of extended-spectrum beta-lactamases in members of the genus Shigella in the Republic of Korea.
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Shigella sonnei isolates from South Korea, including TEM-15, TEM-17, TEM-19, TEM-20, TEM-52, and CTX-M-14, which confer resistance to ceftazidime and cefotaxime.
Occurrence of extended-spectrum beta-lactamases in members of the genus Shigella in the Republic of Korea.
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Shigella sonnei isolates from South Korea, including TEM-15, TEM-17, TEM-19, TEM-20, TEM-52, and CTX-M-14, which confer resistance to ceftazidime and cefotaxime.
Occurrence of extended-spectrum beta-lactamases in members of the genus Shigella in the Republic of Korea.
The study identifies several extended-spectrum beta-lactamases (ESBLs) in Shigella sonnei isolates from South Korea, including TEM-15, TEM-17, TEM-19, TEM-20, TEM-52, and CTX-M-14, which confer resistance to ceftazidime and cefotaxime.
TEM-121, a novel complex mutant of TEM-type beta-lactamase from Enterobacter aerogenes.
The study identifies TEM-121, a novel complex mutant TEM-type beta-lactamase from Enterobacter aerogenes, which exhibits unique resistance properties against ceftazidime and aztreonam while showing reduced susceptibility to clavulanic acid.
TEM-121, a novel complex mutant of TEM-type beta-lactamase from Enterobacter aerogenes.
TEM-121, a novel complex mutant of TEM-type beta-lactamase from Enterobacter aerogenes.
TEM-121, a novel complex mutant of TEM-type beta-lactamase from Enterobacter aerogenes.
TEM-121, a novel complex mutant of TEM-type beta-lactamase from Enterobacter aerogenes.
Extended-Spectrum beta-lactamase (ESBL) producing Enterobacter aerogenes phenotypically misidentified as Klebsiella pneumoniae or K. terrigena.
The study identifies TEM-5 and SHV-4 beta-lactamase genes in Enterobacter aerogenes isolates that were misclassified as Klebsiella pneumoniae or K. terrigena due to delayed biochemical test results. These genes confer resistance to ceftazidime and aztreonam.
Prevalence of beta-lactamases among ampicillin-resistant Escherichia coli and Salmonella isolated from food animals in Denmark.
Prevalence of beta-lactamases among ampicillin-resistant Escherichia coli and Salmonella isolated from food animals in Denmark.
Prevalence of beta-lactamases among ampicillin-resistant Escherichia coli and Salmonella isolated from food animals in Denmark.
Prevalence of beta-lactamases among ampicillin-resistant Escherichia coli and Salmonella isolated from food animals in Denmark.
Prevalence of beta-lactamases among ampicillin-resistant Escherichia coli and Salmonella isolated from food animals in Denmark.
Prevalence of beta-lactamases among ampicillin-resistant Escherichia coli and Salmonella isolated from food animals in Denmark.
Prevalence of beta-lactamases among ampicillin-resistant Escherichia coli and Salmonella isolated from food animals in Denmark.
Prevalence of beta-lactamases among ampicillin-resistant Escherichia coli and Salmonella isolated from food animals in Denmark.
Cats as a risk for transmission of antimicrobial drug-resistant Salmonella.
The study identified several antimicrobial resistance genes in Salmonella isolates from cats, including blaTEM, cat, sul2, tet(A), and dfrA1, which confer resistance to ampicillin, chloramphenicol, sulfonamides, tetracycline, and trimethoprim, respectively.
Multidrug-resistant Salmonella enterica serovar Muenchen from pigs and humans and potential interserovar transfer of antimicrobial resistance.
The study identifies several AMR genes in multidrug-resistant Salmonella enterica serovar Muenchen isolates from pigs and humans, including blaOXA-30, aadA2, aphA1-Iab, tetA(B), blaTEM, strA, cmlA, and tetA(A). These genes confer resistance to various antibiotics such as ampicillin, amoxicillin-clavulanic acid, streptomycin, kanamycin, tetracycline, chloramphenicol, and gentamicin.
Extended-spectrum beta-lactamases among Enterobacter isolates obtained in Tel Aviv, Israel.
The study identified the presence of extended-spectrum beta-lactamases (ESBLs) in Enterobacter isolates, including TEM-1, SHV-12, CTX-M-2, and CTX-M-26, which confer resistance to various beta-lactam antibiotics.
Physical linkage of Tn3 and part of Tn1721 in a tetracycline and ampicillin resistance plasmid from Salmonella Typhimurium.
Physical linkage of Tn3 and part of Tn1721 in a tetracycline and ampicillin resistance plasmid from Salmonella Typhimurium.
Physical linkage of Tn3 and part of Tn1721 in a tetracycline and ampicillin resistance plasmid from Salmonella Typhimurium.
Physical linkage of Tn3 and part of Tn1721 in a tetracycline and ampicillin resistance plasmid from Salmonella Typhimurium.
The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen.
The study identifies multiple antimicrobial resistance genes on plasmids pSC138 and pSCV50 in Salmonella enterica serovar Choleraesuis SC-B67, including blaTEM-1, blaCMY-2, tetRA, strA, aadA2, sulI, sulII, catI, cmlA, aph, sat, mef, mer, ebr, qac, and blaTEM-67. Additionally, mutations in the chromosomal genes gyrA and parC, along with the inactivation of acrR, contribute to ciprofloxacin resistance.
The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen.
The study identifies multiple antimicrobial resistance genes on plasmids pSC138 and pSCV50 in Salmonella enterica serovar Choleraesuis SC-B67, including blaTEM-1, blaCMY-2, tetRA, strA, aadA2, sulI, sulII, catI, cmlA, aph, sat, mef, mer, ebr, qac, and blaTEM-67. Additionally, mutations in the chromosomal genes gyrA and parC, along with the inactivation of acrR, contribute to ciprofloxacin resistance.
Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate.
The study identifies a novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate, which shows resistance to ceftazidime and cefotaxime.
Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate.
Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate.
Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate.
Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate.
Evolution of TEM-Type Extended-Spectrum β-Lactamases in Clinical Enterobacteriaceae Strains in Poland.
The study identifies four novel TEM-type extended-spectrum beta-lactamases (TEM-85, TEM-86, TEM-93, and TEM-94) in clinical Enterobacteriaceae strains in Poland, demonstrating their resistance to ceftazidime and cefotaxime.
Evolution of TEM-Type Extended-Spectrum β-Lactamases in Clinical Enterobacteriaceae Strains in Poland.
The study identifies four novel TEM-type extended-spectrum beta-lactamases (TEM-85, TEM-86, TEM-93, and TEM-94) in clinical Enterobacteriaceae strains in Poland, demonstrating their resistance to ceftazidime and cefotaxime.
Evolution of TEM-Type Extended-Spectrum β-Lactamases in Clinical Enterobacteriaceae Strains in Poland.
The study identifies four novel TEM-type extended-spectrum beta-lactamases (TEM-85, TEM-86, TEM-93, and TEM-94) in clinical Enterobacteriaceae strains in Poland, demonstrating their resistance to ceftazidime and cefotaxime.
Evolution of TEM-Type Extended-Spectrum β-Lactamases in Clinical Enterobacteriaceae Strains in Poland.
The study identifies four novel TEM-type extended-spectrum beta-lactamases (TEM-85, TEM-86, TEM-93, and TEM-94) in clinical Enterobacteriaceae strains in Poland, demonstrating their resistance to ceftazidime and cefotaxime.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Nationwide study of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases in Spain.
Nationwide study of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases in Spain.
Nationwide study of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases in Spain.
Nationwide study of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases in Spain.
Occurrence and molecular analysis of extended-spectrum {beta}-lactamase-producing Proteus mirabilis in Hong Kong, 1999-2002.
Proteus mirabilis bloodstream infections: risk factors and treatment outcome related to the expression of extended-spectrum beta-lactamases.
The study identified blaTEM-52 and blaTEM-92 genes in Proteus mirabilis isolates, which confer resistance to ceftazidime, cefotaxime, and cefepime. These genes were found in ESBL-producing isolates and were associated with increased mortality and treatment failure.
Proteus mirabilis bloodstream infections: risk factors and treatment outcome related to the expression of extended-spectrum beta-lactamases.
The study identified blaTEM-52 and blaTEM-92 genes in Proteus mirabilis isolates, which confer resistance to ceftazidime, cefotaxime, and cefepime. These genes were found in ESBL-producing isolates and were associated with increased mortality and treatment failure.
Survey of Enterobacteriaceae producing extended-spectrum beta-lactamases in a Slovak hospital: dominance of SHV-2a and characterization of TEM-132.
The study identified the dominant extended-spectrum beta-lactamase SHV-2a and characterized the novel TEM-132 enzyme in Enterobacteriaceae isolates from a Slovak hospital.
Survey of Enterobacteriaceae producing extended-spectrum beta-lactamases in a Slovak hospital: dominance of SHV-2a and characterization of TEM-132.
Survey of Enterobacteriaceae producing extended-spectrum beta-lactamases in a Slovak hospital: dominance of SHV-2a and characterization of TEM-132.
Survey of Enterobacteriaceae producing extended-spectrum beta-lactamases in a Slovak hospital: dominance of SHV-2a and characterization of TEM-132.
Survey of Enterobacteriaceae producing extended-spectrum beta-lactamases in a Slovak hospital: dominance of SHV-2a and characterization of TEM-132.
Molecular characterization of multidrug-resistant Proteus mirabilis isolates from retail meat products.
The study identified several AMR genes including aadA1, aadB, aadA2, dhfr1, sat1, and blaTEM-1 in multidrug-resistant Proteus mirabilis isolates from retail meat products. Mutations in gyrA and parC were also linked to nalidixic acid resistance.
Prolonged outbreak of infection due to TEM-21-producing strains of Pseudomonas aeruginosa and enterobacteria in a nursing home.
The study identifies the TEM-21 beta-lactamase and aac(3)-II aminoglycoside acetyltransferase as the primary resistance mechanisms in Pseudomonas aeruginosa and Enterobacteriaceae isolates causing a prolonged outbreak in a nursing home.
Unexpected enzyme TEM-126: role of mutation Asp179Glu.
The study identifies TEM-126, a novel TEM-type extended-spectrum beta-lactamase with the mutations Asp179Glu and Met182Thr, which confers resistance to ceftazidime.
Clinical and molecular analysis of extended-spectrum {beta}-lactamase-producing enterobacteria in the community setting.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla TEM-24b, bla TEM-21, bla TEM-15, and bla SHV-4, which confer resistance to various beta-lactam antibiotics and other antimicrobials.
Clinical and molecular analysis of extended-spectrum {beta}-lactamase-producing enterobacteria in the community setting.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla TEM-24b, bla TEM-21, bla TEM-15, and bla SHV-4, which confer resistance to various beta-lactam antibiotics and other antimicrobials.
Clinical and molecular analysis of extended-spectrum {beta}-lactamase-producing enterobacteria in the community setting.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla TEM-24b, bla TEM-21, bla TEM-15, and bla SHV-4, which confer resistance to various beta-lactam antibiotics and other antimicrobials.
TEM-109 (CMT-5), a natural complex mutant of TEM-1 beta-lactamase combining the amino acid substitutions of TEM-6 and TEM-33 (IRT-5).
The study identifies TEM-109, a novel complex mutant beta-lactamase combining substitutions from TEM-6 and TEM-33, which confers resistance to amoxicillin, ticarcillin, and ceftazidime.
TEM-109 (CMT-5), a natural complex mutant of TEM-1 beta-lactamase combining the amino acid substitutions of TEM-6 and TEM-33 (IRT-5).
TEM-109 (CMT-5), a natural complex mutant of TEM-1 beta-lactamase combining the amino acid substitutions of TEM-6 and TEM-33 (IRT-5).
TEM-109 (CMT-5), a natural complex mutant of TEM-1 beta-lactamase combining the amino acid substitutions of TEM-6 and TEM-33 (IRT-5).
TEM-109 (CMT-5), a natural complex mutant of TEM-1 beta-lactamase combining the amino acid substitutions of TEM-6 and TEM-33 (IRT-5).
Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla SHV-2a, bla SHV-5, bla SHV-8, bla SHV-11, bla SHV-12, bla TEM-1, bla TEM-24, bla TEM-93, and bla TEM-116, in Klebsiella pneumoniae isolates. These genes confer resistance to cephalosporins, penicillins, and monobactams.
Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla SHV-2a, bla SHV-5, bla SHV-8, bla SHV-11, bla SHV-12, bla TEM-1, bla TEM-24, bla TEM-93, and bla TEM-116, in Klebsiella pneumoniae isolates. These genes confer resistance to cephalosporins, penicillins, and monobactams.
Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla SHV-2a, bla SHV-5, bla SHV-8, bla SHV-11, bla SHV-12, bla TEM-1, bla TEM-24, bla TEM-93, and bla TEM-116, in Klebsiella pneumoniae isolates. These genes confer resistance to cephalosporins, penicillins, and monobactams.
Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla SHV-2a, bla SHV-5, bla SHV-8, bla SHV-11, bla SHV-12, bla TEM-1, bla TEM-24, bla TEM-93, and bla TEM-116, in Klebsiella pneumoniae isolates. These genes confer resistance to cephalosporins, penicillins, and monobactams.
New TEM-derived extended-spectrum beta-lactamase and its genomic context in plasmids from Salmonella enterica serovar derby isolates from Uruguay.
The study identified a new TEM-derived extended-spectrum beta-lactamase, TEM-144, which confers resistance to ceftazidime. This enzyme differs from TEM-1 by two mutations (R164C and E240K) and from TEM-91 by one mutation (T182M).
New TEM-derived extended-spectrum beta-lactamase and its genomic context in plasmids from Salmonella enterica serovar derby isolates from Uruguay.
New TEM-derived extended-spectrum beta-lactamase and its genomic context in plasmids from Salmonella enterica serovar derby isolates from Uruguay.
New TEM-derived extended-spectrum beta-lactamase and its genomic context in plasmids from Salmonella enterica serovar derby isolates from Uruguay.
New TEM-derived extended-spectrum beta-lactamase and its genomic context in plasmids from Salmonella enterica serovar derby isolates from Uruguay.
Sequence of the genes blaT-1B and blaT-2., A TEM-2beta-lactamase encoded on an active Tn1-like transposon in the genome of a clinical isolate of Stenotrophomonas maltophilia.
Multidrug resistance in Salmonella enterica serotype Typhimurium from humans in France (1993 to 2003).
The study identified multiple AMR genes and mutations in Salmonella enterica serotype Typhimurium isolates from humans in France, including bla PSE-1, bla TEM, bla OXA-30, and qnrA, as well as mutations in gyrA conferring resistance to ciprofloxacin.
Molecular epidemiology of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit.
Molecular epidemiology of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit.
Molecular epidemiology of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit.
Molecular epidemiology of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit.
Resistance of strains producing extended-spectrum beta-lactamases and genotype distribution in China.
Resistance of strains producing extended-spectrum beta-lactamases and genotype distribution in China.
Resistance of strains producing extended-spectrum beta-lactamases and genotype distribution in China.
An IS1-like element is responsible for high-level synthesis of extended-spectrum beta-lactamase TEM-6 in Enterobacteriaceae.
Longitudinal farm study of extended-spectrum beta-lactamase-mediated resistance.
The study identified bla CTX-M14/17 and bla TEM-35 genes in E. coli isolates from calves, demonstrating their role in extended-spectrum beta-lactamase-mediated resistance. The genes were found to be transferable via plasmids, contributing to the spread of resistance on the farm.
Multidrug-resistant commensal Escherichia coli in children, Peru and Bolivia.
The study identified multiple multidrug-resistant commensal E. coli isolates in children from Peru and Bolivia, highlighting the prevalence of resistance genes such as blaTEM, tet(A), tet(B), dfrA8, sul1, sul2, and catI.
Extended-spectrum beta-lactamase-producing Enterobacteriaceae, Central African Republic.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla SHV-2a, bla SHV-12, bla CTX-M-15, and bla CTX-M-3, in Enterobacteriaceae isolates from the Central African Republic. These genes conferred resistance to various beta-lactam antibiotics.
CMT-type beta-lactamase TEM-125, an emerging problem for extended-spectrum beta-lactamase detection.
The study identifies TEM-125, a novel CMT-type beta-lactamase that confers resistance to ceftazidime and shows high resistance to clavulanate, making it challenging to detect as an ESBL using conventional methods.
CMT-type beta-lactamase TEM-125, an emerging problem for extended-spectrum beta-lactamase detection.
CMT-type beta-lactamase TEM-125, an emerging problem for extended-spectrum beta-lactamase detection.
CMT-type beta-lactamase TEM-125, an emerging problem for extended-spectrum beta-lactamase detection.
CMT-type beta-lactamase TEM-125, an emerging problem for extended-spectrum beta-lactamase detection.
Identification and characterization of bacterial pathogens causing bloodstream infections by DNA microarray.
The study identifies and characterizes bacterial pathogens causing bloodstream infections using a DNA microarray. It highlights the presence of resistance genes such as mecA, blaZ, ermA, aacA-aphD, blaTEM-106, and aacC2, which confer resistance to various antibiotics.
A novel extended-spectrum TEM-type beta-lactamase, TEM-138, from Salmonella enterica serovar Infantis.
A novel extended-spectrum TEM-type beta-lactamase, TEM-138, was identified in a ceftazidime-resistant clinical isolate of Salmonella enterica serovar Infantis. TEM-138 contains the mutations E104K, N175I, and G238S and confers resistance to ceftazidime and cefotaxime.
A novel extended-spectrum TEM-type beta-lactamase, TEM-138, from Salmonella enterica serovar Infantis.
A novel extended-spectrum TEM-type beta-lactamase, TEM-138, from Salmonella enterica serovar Infantis.
A novel extended-spectrum TEM-type beta-lactamase, TEM-138, from Salmonella enterica serovar Infantis.
A novel extended-spectrum TEM-type beta-lactamase, TEM-138, from Salmonella enterica serovar Infantis.
Evaluation of the new VITEK 2 extended-spectrum beta-lactamase (ESBL) test for rapid detection of ESBL production in Enterobacteriaceae isolates.
The study evaluated the VITEK 2 ESBL test for rapid detection of ESBL-producing Enterobacteriaceae isolates, identifying bla TEM, bla SHV, and bla CTX-M genes as major contributors to extended-spectrum beta-lactamase production.
Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center.
The study identified multiple antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates, including bla ADC, bla OXA-69-like, bla OXA-23-like, bla OXA-58-like, bla TEM, bla PER, aacC1, aacC2, aadA1, aadB, and aphA6, which confer resistance to various antibiotics such as ceftazidime, cefepime, imipenem, meropenem, ampicillin, ampicillin-sulbactam, gentamicin, tobramycin, streptomycin, spectinomycin, amikacin, kanamycin, and neomycin.
Sources of variation in the ampicillin-resistant Escherichia coli concentration in the feces of organic broiler chickens.
The study identified blaTEM genes as a cause of ampicillin resistance in Escherichia coli isolated from organic broiler chickens.
Evaluation of a new selective chromogenic agar medium for detection of extended-spectrum beta-lactamase-producing Enterobacteriaceae.
The study evaluates a new chromogenic agar medium (ESBL-Bx) for detecting extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae. It identifies bla TEM, bla SHV, and bla CTX-M genes as the primary resistance mechanisms.
Population structure and resistance genes in antibiotic-resistant bacteria from a remote community with minimal antibiotic exposure.
The study identified various acquired antibiotic resistance genes in commensal E. coli isolates from a remote community with minimal antibiotic exposure, including blaTEM, catI, cmlA6, tet(A), tet(B), dfrA1, dfrA7, dfrA8, dfrA17, sul1, sul2, aphA1, aadA1, aadA2, aadA5, aadB, and sat-1. These genes were found to be similar to those seen in antibiotic-exposed settings, indicating the dissemination of resistant bacteria and resistance genes from such environments.
Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.
The study identifies two new complex mutant TEM enzymes, TEM-151 and TEM-152, which exhibit resistance to ceftazidime and show distinct mutational profiles compared to previously known TEM variants.
Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.
The study identifies two new complex mutant TEM enzymes, TEM-151 and TEM-152, which exhibit resistance to ceftazidime and show distinct mutational profiles compared to previously known TEM variants.
Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.
Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.
Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.
Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.
Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.
Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.
Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.
Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.
Detection of extended-spectrum beta-lactamases by using boronic acid as an AmpC beta-lactamase inhibitor in clinical isolates of Klebsiella spp. and Escherichia coli.
The study evaluates the use of boronic acid as an inhibitor to enhance the detection of extended-spectrum beta-lactamases (ESBLs) in clinical isolates of Klebsiella spp. and Escherichia coli, particularly in cases where ESBLs may be masked by plasmid-mediated AmpC beta-lactamases (pAmpCs).
Dissemination of an extended-spectrum-beta-lactamase blaTEM-52 gene-carrying IncI1 plasmid in various Salmonella enterica serovars isolated from poultry and humans in Belgium and France between 2001 and 2005.
The study reports the dissemination of a conjugative IncI1 plasmid carrying the blaTEM-52 gene, which confers resistance to extended-spectrum cephalosporins in various Salmonella enterica serovars isolated from poultry and humans in Belgium and France between 2001 and 2005.
Dissemination of an extended-spectrum-beta-lactamase blaTEM-52 gene-carrying IncI1 plasmid in various Salmonella enterica serovars isolated from poultry and humans in Belgium and France between 2001 and 2005.
Dissemination and persistence of a plasmid-mediated TEM-3-like beta-lactamase, TEM-139, among Enterobacteriaceae in Bulgaria.
Dissemination and persistence of a plasmid-mediated TEM-3-like beta-lactamase, TEM-139, among Enterobacteriaceae in Bulgaria.
Dissemination and persistence of a plasmid-mediated TEM-3-like beta-lactamase, TEM-139, among Enterobacteriaceae in Bulgaria.
Dissemination and persistence of a plasmid-mediated TEM-3-like beta-lactamase, TEM-139, among Enterobacteriaceae in Bulgaria.
Ertapenem resistance of Escherichia coli.
The study reports the first ertapenem-resistant Escherichia coli isolate producing a CTX-M-type ESBL and deficient in porin OmpC, highlighting the potential for carbapenem resistance development.
Cytoplasmic-membrane anchoring of a class A beta-lactamase and its capacity in manifesting antibiotic resistance.
The study demonstrates that the TEM-1 beta-lactamase, when anchored to the cytoplasmic membrane, confers resistance to ampicillin in E. coli.
Impact of Three Ampicillin Dosage Regimens on Selection of Ampicillin Resistance in Enterobacteriaceae and Excretion of blaTEM Genes in Swine Feces.
The study found that ampicillin resistance in Enterobacteriaceae and the excretion of blaTEM genes in swine feces were significantly influenced by the dosage regimen of ampicillin. The blaTEM gene was identified as a key factor in ampicillin resistance.
Novel extended-spectrum beta-lactamase in Shigella sonnei.
Novel extended-spectrum beta-lactamase in Shigella sonnei.
Novel extended-spectrum beta-lactamase in Shigella sonnei.
Novel extended-spectrum beta-lactamase in Shigella sonnei.
Nosocomial outbreak due to extended-spectrum-beta-lactamase-producing Enterobacter cloacae in a cardiothoracic intensive care unit.
The study identifies the presence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacter cloacae in a cardiothoracic intensive care unit, highlighting the role of bla SHV, bla TEM, and CTX-M-9 genes in conferring resistance to cephalosporins.
Multiplex Asymmetric PCR-Based Oligonucleotide Microarray for Detection of Drug Resistance Genes Containing Single Mutations in Enterobacteriaceae
The study developed a multiplex asymmetric PCR-based microarray for detecting drug resistance genes containing single mutations in Enterobacteriaceae, focusing on beta-lactamase genes such as bla SHV, bla TEM, bla CTX-M-3, bla CTX-M-9, bla DHA-1, bla CMY-2, bla MOX-1, bla ACC-1, bla FOX-5, and bla MIR-1. It also identified six point mutations in the bla SHV gene.
Complete nucleotide sequence of the pCTX-M3 plasmid and its involvement in spread of the extended-spectrum beta-lactamase gene blaCTX-M-3.
The study characterizes the pCTX-M3 plasmid, which carries the blaCTX-M-3 gene, a extended-spectrum beta-lactamase, along with other resistance genes such as blaTEM-1, aadA2, aacC2, armA, dfrA12, and sul1, contributing to resistance against beta-lactams, aminoglycosides, and sulfonamides.
TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases.
The study identifies TEM-158, a new CMT-type extended-spectrum beta-lactamase with substitutions previously seen in TEM-12 and TEM-35, showing resistance to ceftazidime and reduced susceptibility to clavulanate.
TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases.
TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases.
TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases.
TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases.
Zoo animals as reservoirs of gram-negative bacteria harboring integrons and antimicrobial resistance genes.
The study identified various antimicrobial resistance genes in gram-negative bacteria isolated from zoo animals, including bla TEM-1, bla OXY-2, bla SHV-36, bla CTX-M-2, bla CMY-26, qnrB, qnrS, and aac(6')-Ib-cr.
Impact of feed supplementation with antimicrobial agents on growth performance of broiler chickens, Clostridium perfringens and enterococcus counts, and antibiotic resistance phenotypes and distribution of antimicrobial resistance determinants in Escherichia coli isolates.
The study identified several AMR genes in E. coli isolates from broiler chickens, including blaTEM, blaSHV, aadA, tet(A), tet(B), sulI, sulII, and floR, which conferred resistance to various antibiotics such as amoxicillin, tetracycline, sulfonamides, and chloramphenicol.
Characterization of CTX-M-22 and TEM-141 Encoded by a single plasmid from a clinical isolate of Enterobacter cloacae in China.
Characterization of CTX-M-22 and TEM-141 Encoded by a single plasmid from a clinical isolate of Enterobacter cloacae in China.
Characterization of CTX-M-22 and TEM-141 Encoded by a single plasmid from a clinical isolate of Enterobacter cloacae in China.
Characterization of CTX-M-22 and TEM-141 Encoded by a single plasmid from a clinical isolate of Enterobacter cloacae in China.
High diversity of extended-spectrum beta-lactamases among clinical isolates of Enterobacteriaceae from Portugal.
High diversity of extended-spectrum beta-lactamases among clinical isolates of Enterobacteriaceae from Portugal.
High diversity of extended-spectrum beta-lactamases among clinical isolates of Enterobacteriaceae from Portugal.
High diversity of extended-spectrum beta-lactamases among clinical isolates of Enterobacteriaceae from Portugal.
Molecular epidemiology of Escherichia coli producing extended-spectrum beta-lactamases isolated in Rome, Italy.
The study identifies blaCTX-M-15 as the predominant ESBL gene in E. coli isolates from Rome, Italy, with 26 out of 28 isolates carrying this gene. Other ESBL genes identified include blaCTX-M-14, blaSHV-12, blaTEM-1, and blaOXA-1.
E240V Substitution Increases Catalytic Efficiency toward Ceftazidime in a New Natural TEM-Type Extended-Spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens Clinical Isolates.
The study characterizes TEM-149, a new natural TEM-type extended-spectrum beta-lactamase with an E240V substitution that enhances catalytic efficiency towards ceftazidime, cefotaxime, and aztreonam.
E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates.
E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates.
E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates.
E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates.
Nasopharyngeal Haemophilus influenzae carriage in Japanese children attending day-care centers.
Successive emergence of extended-spectrum beta-lactamase-producing and carbapenemase-producing Enterobacter aerogenes isolates in a university hospital.
The study identifies bla TEM-24, bla SHV-12, bla IMP-1, and bla VIM-2 as the primary resistance genes in carbapenem-resistant Enterobacter aerogenes isolates, highlighting the role of beta-lactamases in resistance to various antibiotics.
Characterization of extended-spectrum beta-lactamase-producing isolates of Haemophilus parainfluenzae.
Different pathways to acquiring resistance genes illustrated by the recent evolution of IncW plasmids.
The study characterizes the acquisition of resistance genes via different pathways in IncW plasmids, highlighting the role of integrons and transposons in the spread of antibiotic resistance.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains.
The study identifies several AMR genes and mutations associated with resistance to penicillin, tetracycline, and fluoroquinolones in Neisseria gonorrhoeae, including bla TEM-1, tet (M), and various mutations in penA, penB, mtrR, ponA, rpsJ, gyrA, and parC.
Longitudinal study of antimicrobial resistance among Escherichia coli isolates from integrated multisite cohorts of humans and swine.
The study identified various AMR genes in E. coli isolates from humans and swine, highlighting differences in resistance profiles between the two hosts. Key genes included beta-lactamases (blaCTX-M, blaTEM, blaSHV), aminoglycoside modifying enzymes (aac(6')-Ib, aadA), tetracycline resistance (tet(A)), quinolone resistance (qnrS1), macrolide resistance (erm(B)), and efflux pumps (mexAB-OprM).
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
The study identified various beta-lactamases, including CTX-M-3, CTX-M-15, SHV-2, SHV-5, SHV-12, TEM-19, TEM-48, CMY-12, CMY-15, CMY-38, TEM-30, TEM-32, TEM-37, and SHV-49, which confer resistance to newer beta-lactam antibiotics in Enterobacteriaceae isolates from Polish hospitals.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
The study identified various beta-lactamases, including CTX-M-3, CTX-M-15, SHV-2, SHV-5, SHV-12, TEM-19, TEM-48, CMY-12, CMY-15, CMY-38, TEM-30, TEM-32, TEM-37, and SHV-49, which confer resistance to newer beta-lactam antibiotics in Enterobacteriaceae isolates from Polish hospitals.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
The study identified various beta-lactamases, including CTX-M-3, CTX-M-15, SHV-2, SHV-5, SHV-12, TEM-19, TEM-48, CMY-12, CMY-15, CMY-38, TEM-30, TEM-32, TEM-37, and SHV-49, which confer resistance to newer beta-lactam antibiotics in Enterobacteriaceae isolates from Polish hospitals.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
The study identified various beta-lactamases, including CTX-M-3, CTX-M-15, SHV-2, SHV-5, SHV-12, TEM-19, TEM-48, CMY-12, CMY-15, CMY-38, TEM-30, TEM-32, TEM-37, and SHV-49, which confer resistance to newer beta-lactam antibiotics in Enterobacteriaceae isolates from Polish hospitals.
Molecular survey of beta-lactamases conferring resistance to newer beta-lactams in Enterobacteriaceae isolates from Polish hospitals.
The study identified various beta-lactamases, including CTX-M-3, CTX-M-15, SHV-2, SHV-5, SHV-12, TEM-19, TEM-48, CMY-12, CMY-15, CMY-38, TEM-30, TEM-32, TEM-37, and SHV-49, which confer resistance to newer beta-lactam antibiotics in Enterobacteriaceae isolates from Polish hospitals.
Antibiotic Resistance in Haemophilus influenzae Decreased, except for β-Lactamase-Negative Amoxicillin-Resistant Isolates, in Parallel with Community Antibiotic Consumption in Spain from 1997 to 2007.
The study found that antibiotic resistance in Haemophilus influenzae decreased in Spain from 1997 to 2007, except for β-lactamase-negative amoxicillin-resistant isolates. The blaTEM-1 gene was identified as a key factor in β-lactam resistance.
Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic.
The study identified the high prevalence of bla CTX-M genes in ESBL-producing E. coli and K. pneumoniae isolates in Thailand, highlighting the endemic nature of CTX-M-type ESBLs. It also reported the first detection of CTX-M-3, CTX-M-27, CTX-M-40, SHV-27, SHV-71, and SHV-75 in Thailand.
Expanded molecular diversity generation during directed evolution by trinucleotide exchange (TriNEx).
The study demonstrates the use of TriNEx to generate diverse TEM-1 beta-lactamase variants with improved activity against ceftazidime and resistance to clavulanate through targeted mutagenesis.
Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Escherichia coli: risk factors for inadequate initial antimicrobial therapy.
The study identifies bla CTX-M, bla SHV, and bla TEM genes as the primary mechanisms of extended-spectrum beta-lactamase (ESBL) production in Escherichia coli causing bloodstream infections, highlighting their role in resistance to various beta-lactam antibiotics.
Occupational transmission of Acinetobacter baumannii from a United States serviceman wounded in Iraq to a health care worker.
The study identifies β-lactamase genes blaTEM, blaADC, and blaOXA-51/69-like, aminoglycoside-modifying enzymes aacC1 and aadA1, and quinolone resistance mutations in gyrA and parC in multidrug-resistant Acinetobacter baumannii isolates from a healthcare worker and a patient.
Molecular characterization of extended-spectrum beta-lactamases produced by clinical isolates of Enterobacter cloacae from a Teaching Hospital in China.
Molecular characterization of extended-spectrum beta-lactamases produced by clinical isolates of Enterobacter cloacae from a Teaching Hospital in China.
Molecular characterization of extended-spectrum beta-lactamases produced by clinical isolates of Enterobacter cloacae from a Teaching Hospital in China.
Novel insertion sequence- and transposon-mediated genetic rearrangements in genomic island SGI1 of Salmonella enterica serovar Kentucky.
The study identifies the beta-lactamase gene blaTEM-1 in the Salmonella genomic island SGI1 of Salmonella enterica serovar Kentucky, contributing to ampicillin resistance.
Transfer of antimicrobial resistance plasmids from Klebsiella pneumoniae to Escherichia coli in the mouse intestine.
The study demonstrates the transfer of antimicrobial resistance plasmids from Klebsiella pneumoniae to Escherichia coli in the mouse intestine, highlighting the role of antimicrobial treatment in selecting for resistant strains and facilitating gene transfer.
Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experience.
The study identifies multiple beta-lactamase genes, including bla CMY-2, bla DHA, bla TEM, bla CTX-M, bla IMP-4, and bla KPC-2, contributing to broad-spectrum beta-lactam resistance in Enterobacteriaceae isolates from a children's hospital.
ESBL genotypes in fluoroquinolone-resistant and fluoroquinolone-susceptible ESBL-producing Escherichia coli urinary isolates in Manitoba.
The study identifies CTX-M-15 as being strongly associated with multidrug resistance (MDR) in E. coli, while CTX-M-14 is linked primarily to fluoroquinolone (FQ) resistance. Other ESBL genotypes such as CTX-M-9, CTX-M-24, SHV, and TEM were also characterized.
Sec- and Tat-Dependent Translocation of beta-Lactamases across the Escherichia coli Inner Membrane
Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-2, bla CTX-M-5, bla CTX-M-15, bla CTX-M-22, bla CTX-M-28, bla SHV-5, bla SHV-12, bla TEM-1, bla OXA-1, bla OXA-2, bla OXA-5, bla PER-1, bla ACT-1, bla MIR-1, bla CMY-2, bla FOX-1, bla DHA-1, and bla KPC-2, in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates.
Major enzymatic factors involved in bacterial penicillin resistance in Burkina Faso.
The study identified blaTEM-1 and blaSHV-1 as the primary beta-lactamase genes responsible for penicillin resistance in Escherichia coli and Klebsiella pneumoniae isolates from Burkina Faso.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
The study identifies three novel beta-lactamase genes, blaSHV-48, blaSHV-105, and blaTEM-155, which confer resistance to various beta-lactam antibiotics.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.
Unreliable extended-spectrum beta-lactamase detection in the presence of plasmid-mediated AmpC in Escherichia coli clinical isolates.
The study highlights the challenges in detecting extended-spectrum beta-lactamase (ESBL) in the presence of plasmid-mediated AmpC (pAmpC) in E. coli clinical isolates, identifying several ESBL genes (blaTEM-1, blaSHV, blaCTX-M) and pAmpC genes (cmrA, FOX-5) that contribute to resistance against various beta-lactam antibiotics.
Relatedness of Escherichia coli strains with different susceptibility phenotypes isolated from swine feces during ampicillin treatment.
The study identified the blaTEM gene as a key determinant of ampicillin resistance in Escherichia coli strains isolated from swine feces during ampicillin treatment.
P1A Recombinant β-Lactamase Prevents Emergence of Antimicrobial Resistance in Gut Microflora of Healthy Subjects during Intravenous Administration of Ampicillin
The study demonstrates that P1A recombinant beta-lactamase prevents the emergence of ampicillin resistance in gut microflora by degrading antibiotic residues, thereby reducing the number of TEM beta-lactamase genes and ampicillin-resistant coliforms.
Diarrhoeagenic Escherichia coli are not a significant cause of diarrhoea in hospitalised children in Kuwait.
The study identified the presence of extended-spectrum beta-lactamase (ESBL) producing diarrhoeagenic Escherichia coli (DEC) strains, particularly those carrying bla CTX-M, bla TEM, and IS Ecp1 genes, which conferred resistance to cephalosporins.
Resistance to β-lactams in bacteria isolated from different types of Portuguese cheese.
The study identified the bla TEM gene as the predominant β-lactam resistance gene in β-lactam-resistant bacteria isolated from Portuguese cheese, highlighting the potential risk of transferring antibiotic-resistant bacteria through food.
Contribution of gene amplification to evolution of increased antibiotic resistance in Salmonella typhimurium.
The study demonstrates that gene amplification of bla TEM-1 is a primary mechanism for increased cephalosporin resistance in Salmonella typhimurium, followed by secondary mutations in envZ, cpxA, and nmpC that reduce porin expression and enhance resistance.
Antimicrobial resistance genes in Escherichia coli isolates recovered from a commercial beef processing plant
The study identified various antimicrobial resistance genes in E. coli isolates from a commercial beef processing plant, including beta-lactamase genes (blaCMY, blaSHV, blaTEM), tetracycline resistance genes (tetA, tetB, tetC), sulfonamide resistance genes (sul1, sul2), and aminoglycoside resistance genes (strA, strB).
Molecular characterization of extended-spectrum beta-lactamase-producing Escherichia coli isolates from chickens in Henan Province, China.
Characterization of multidrug resistant ESBL-producing Escherichia coli isolates from hospitals in Malaysia.
The study identified several ESBL-encoding genes including blaTEM, blaSHV, blaCTX-M, and blaOXA in multidrug-resistant E. coli isolates from Malaysian hospitals. These genes were found to confer resistance to various beta-lactam antibiotics.
TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate.
The study identifies TEM-168, a novel TEM beta-lactamase variant with a T261M amino acid change, found in a clinical isolate of Escherichia coli. This variant exhibits resistance to several beta-lactam antibiotics.
TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate.
TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate.
TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate.
TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate.
Functional characterization of the antibiotic resistance reservoir in the human microflora.
Functional characterization of the antibiotic resistance reservoir in the human microflora.
Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes.
The study shows that the interplay between the tetracycline resistance efflux pump TetA(C) and the ampicillin resistance gene bla TEM-1 in E. coli biofilms leads to multidrug resistance. The presence of subinhibitory concentrations of ampicillin and tetracycline enhances biofilm formation and resistance to multiple antibiotics.
Characterization of a novel extended-spectrum TEM-type beta-lactamase, TEM-164, in a clinical strain of Klebsiella pneumoniae in Tunisia.
Characterization of a novel extended-spectrum TEM-type beta-lactamase, TEM-164, in a clinical strain of Klebsiella pneumoniae in Tunisia.
Characterization of a novel extended-spectrum TEM-type beta-lactamase, TEM-164, in a clinical strain of Klebsiella pneumoniae in Tunisia.
Characterization of a novel extended-spectrum TEM-type beta-lactamase, TEM-164, in a clinical strain of Klebsiella pneumoniae in Tunisia.
Characterization of the first extended-spectrum beta-lactamase-producing nontyphoidal Salmonella strains isolated in Tehran, Iran.
Characterization of the first extended-spectrum beta-lactamase-producing nontyphoidal Salmonella strains isolated in Tehran, Iran.
Characterization of the first extended-spectrum beta-lactamase-producing nontyphoidal Salmonella strains isolated in Tehran, Iran.
Characterization of the first extended-spectrum beta-lactamase-producing nontyphoidal Salmonella strains isolated in Tehran, Iran.
Salmonella enterica serovar Typhi with CTX-M beta-lactamase, Germany.
Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis.
The study characterizes the TEM-1 beta-lactamase N170G mutant, demonstrating that it hydrolyzes ampicillin efficiently through substrate-assisted catalysis, where the primary amine of the ampicillin R-group positions the hydrolytic water for deacylation.
Antimicrobial resistances do not affect colonization parameters of intestinal E. coli in a small piglet group.
The study identified various AMR genes in commensal E. coli from pigs, including blaTEM, catA1, aph(3')-Ia, aadA, strA/strB, tet(A), tet(B), sul1, sul2, and sul3. These genes conferred resistance to antibiotics such as ampicillin, chloramphenicol, kanamycin, neomycin, streptomycin, spectinomycin, tetracycline, and sulfamethoxazole. However, the presence of these resistance genes did not provide a significant colonization advantage or disadvantage in the pig intestine.
beta-Lactam resistance in salmonella strains isolated from retail meats in the United States by the National Antimicrobial Resistance Monitoring System between 2002 and 2006.
The study identified bla CMY and bla TEM-1 as the primary beta-lactam resistance genes in Salmonella isolates from retail meats, contributing to resistance against multiple beta-lactam antibiotics.
Detection of CTX-M-Type Extended-Spectrum Beta-Lactamase (ESBLs) by Testing with MicroScan Overnight and ESBL Confirmation Panels
The study evaluated the effectiveness of various methods in detecting CTX-M-type extended-spectrum beta-lactamases (ESBLs) in Enterobacteriaceae isolates, identifying several CTX-M variants including CTX-M15, CTX-M16, CTX-M14, CTX-M8, and others, along with SHV and TEM ESBLs.
A unified approach to molecular epidemiology investigations: tools and patterns in California as a case study for endemic shigellosis.
The study identified the presence of tetB, catA, and blaTEM genes in Shigella isolates, which confer resistance to tetracycline, chloramphenicol, and ampicillin, respectively. These genes were detected through PCR analysis in a significant proportion of the isolates.
Updated functional classification of beta-lactamases.
The paper updates the functional classification of beta-lactamases, detailing their substrate preferences, inhibitor profiles, and clinical relevance. It highlights the diversity and evolution of these enzymes, emphasizing their role in antibiotic resistance.
International spread and persistence of TEM-24 is caused by the confluence of highly penetrating enterobacteriaceae clones and an IncA/C2 plasmid containing Tn1696::Tn1 and IS5075-Tn21.
Integrated detection of extended-spectrum-beta-lactam resistance by DNA microarray-based genotyping of TEM, SHV, and CTX-M genes.
The study presents a DNA microarray for the rapid identification of extended-spectrum beta-lactamase (ESBL) genes, including TEM, SHV, and CTX-M, in Enterobacteriaceae. The microarray successfully identified various ESBL variants, with CTX-M-15 and SHV-12 being the most prevalent. The method demonstrated high accuracy and reliability in detecting ESBL-producing isolates.
Seagulls and beaches as reservoirs for multidrug-resistant Escherichia coli.
The study identifies various extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolates, including blaCTX-M-1, blaCTX-M-9, blaCTX-M-15, and blaCTX-M-32, in seagull feces from Porto, Portugal, highlighting their role as reservoirs for multidrug-resistant bacteria.
Bacterial diversity in faeces from polar bear (Ursus maritimus) in Arctic Svalbard.
The study identified bla TEM genes in E. coli isolates from polar bear feces, indicating the presence of ampicillin-resistant bacteria in the polar bear gut microbiota.
Tracking acquired antibiotic resistance in commensal bacteria of Galápagos land iguanas: no man, no resistance.
Two E. coli isolates from Galápagos land iguanas were found to carry acquired resistance genes, including tet(B), aadB, aacA4, cat1, tet(A), blaTEM, and sul1, indicating human-related contamination in a remote ecosystem.
Carriage of genes for various extended-spectrum beta-lactamases: a novel resistance strategy of Klebsiella pneumoniae in Poland.
Carriage of genes for various extended-spectrum beta-lactamases: a novel resistance strategy of Klebsiella pneumoniae in Poland.
Carriage of genes for various extended-spectrum beta-lactamases: a novel resistance strategy of Klebsiella pneumoniae in Poland.
Citrobacter spp. simultaneously harboring blaCTX-M, blaTEM, blaSHV, blaampC, and insertion sequences IS26 and orf513: an evolutionary phenomenon of recent concern for antibiotic resistance.
The study identifies the presence of multiple beta-lactamase genes (blaCTX-M, blaTEM, blaSHV, and blaampC) in Citrobacter spp., highlighting their role in antibiotic resistance. It also reports the association of IS26 and orf513 with these resistance genes, indicating a complex evolutionary mechanism.
Emergence of CTX-M-3, TEM-1 and a new plasmid-mediated MOX-4 AmpC in a multiresistant Aeromonas caviae isolate from a patient with pneumonia.
The study reports the emergence of CTX-M-3, TEM-1, and a novel plasmid-mediated MOX-4 AmpC beta-lactamase in a multidrug-resistant Aeromonas caviae isolate from a pneumonia patient, conferring resistance to various β-lactam antibiotics.
A predominant multidrug-resistant Salmonella enterica serovar Saintpaul clonal line in German turkey and related food products.
Evidence for a second genomic island conferring multidrug resistance in a clonal group of strains of Salmonella enterica serovar Typhimurium and its monophasic variant circulating in Italy, Denmark, and the United Kingdom.
The study identifies the resistance genes bla TEM-1, strA-strB, sul2, and tet(B) in multidrug-resistant Salmonella enterica serovar Typhimurium and its monophasic variant strains, which are chromosomally located and confer resistance to ampicillin, streptomycin, sulfonamides, and tetracycline.
Population analysis and epidemiological features of inhibitor-resistant-TEM-beta-lactamase-producing Escherichia coli isolates from both community and hospital settings in Madrid, Spain.
The study identifies various inhibitor-resistant-TEM (IRT) beta-lactamase variants (TEM-30, TEM-32, TEM-33, TEM-34, TEM-36, TEM-37, TEM-40, and TEM-54) in Escherichia coli isolates, highlighting their role in resistance to amoxicillin-clavulanate.
Population analysis and epidemiological features of inhibitor-resistant-TEM-beta-lactamase-producing Escherichia coli isolates from both community and hospital settings in Madrid, Spain.
The study identifies various inhibitor-resistant-TEM (IRT) beta-lactamase variants (TEM-30, TEM-32, TEM-33, TEM-34, TEM-36, TEM-37, TEM-40, and TEM-54) in Escherichia coli isolates, highlighting their role in resistance to amoxicillin-clavulanate.
Population analysis and epidemiological features of inhibitor-resistant-TEM-beta-lactamase-producing Escherichia coli isolates from both community and hospital settings in Madrid, Spain.
The study identifies various inhibitor-resistant-TEM (IRT) beta-lactamase variants (TEM-30, TEM-32, TEM-33, TEM-34, TEM-36, TEM-37, TEM-40, and TEM-54) in Escherichia coli isolates, highlighting their role in resistance to amoxicillin-clavulanate.
Population analysis and epidemiological features of inhibitor-resistant-TEM-beta-lactamase-producing Escherichia coli isolates from both community and hospital settings in Madrid, Spain.
The study identifies various inhibitor-resistant-TEM (IRT) beta-lactamase variants (TEM-30, TEM-32, TEM-33, TEM-34, TEM-36, TEM-37, TEM-40, and TEM-54) in Escherichia coli isolates, highlighting their role in resistance to amoxicillin-clavulanate.
Population analysis and epidemiological features of inhibitor-resistant-TEM-beta-lactamase-producing Escherichia coli isolates from both community and hospital settings in Madrid, Spain.
The study identifies various inhibitor-resistant-TEM (IRT) beta-lactamase variants (TEM-30, TEM-32, TEM-33, TEM-34, TEM-36, TEM-37, TEM-40, and TEM-54) in Escherichia coli isolates, highlighting their role in resistance to amoxicillin-clavulanate.
Population analysis and epidemiological features of inhibitor-resistant-TEM-beta-lactamase-producing Escherichia coli isolates from both community and hospital settings in Madrid, Spain.
The study identifies various inhibitor-resistant-TEM (IRT) beta-lactamase variants (TEM-30, TEM-32, TEM-33, TEM-34, TEM-36, TEM-37, TEM-40, and TEM-54) in Escherichia coli isolates, highlighting their role in resistance to amoxicillin-clavulanate.
Population analysis and epidemiological features of inhibitor-resistant-TEM-beta-lactamase-producing Escherichia coli isolates from both community and hospital settings in Madrid, Spain.
The study identifies various inhibitor-resistant-TEM (IRT) beta-lactamase variants (TEM-30, TEM-32, TEM-33, TEM-34, TEM-36, TEM-37, TEM-40, and TEM-54) in Escherichia coli isolates, highlighting their role in resistance to amoxicillin-clavulanate.
Population analysis and epidemiological features of inhibitor-resistant-TEM-beta-lactamase-producing Escherichia coli isolates from both community and hospital settings in Madrid, Spain.
The study identifies various inhibitor-resistant-TEM (IRT) beta-lactamase variants (TEM-30, TEM-32, TEM-33, TEM-34, TEM-36, TEM-37, TEM-40, and TEM-54) in Escherichia coli isolates, highlighting their role in resistance to amoxicillin-clavulanate.
Meningitis caused by Escherichia coli producing TEM-52 extended-spectrum beta-lactamase within an extensive outbreak in a neonatal ward: epidemiological investigation and characterization of the strain.
The study identifies TEM-52, an extended-spectrum beta-lactamase, as the resistance mechanism in an outbreak of meningitis caused by Escherichia coli in a neonatal ward.
Enumeration and characterization of antimicrobial-resistant Escherichia coli bacteria in effluent from municipal, hospital, and secondary treatment facility sources.
The study identifies several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-28, bla CTX-M-3, bla CTX-M-61, bla TEM, and bla SHV, which confer resistance to various beta-lactam antibiotics in Escherichia coli isolates from effluent samples.
Evaluation of a DNA microarray, the check-points ESBL/KPC array, for rapid detection of TEM, SHV, and CTX-M extended-spectrum beta-lactamases and KPC carbapenemases.
The Check-Points ESBL/KPC array effectively detects TEM, SHV, CTX-M, and KPC beta-lactamase genes, offering rapid and accurate identification of extended-spectrum beta-lactamases and carbapenemases in clinical isolates.
Complete nucleotide sequence of CTX-M-15-plasmids from clinical Escherichia coli isolates: insertional events of transposons and insertion sequences.
ACC-1 beta-Lactamase-producing Salmonella enterica Serovar Typhi, India.
The study identifies the presence of blaACC-1 and blaTEM-1 beta-lactamase genes in a multidrug-resistant Salmonella enterica serovar Typhi isolate from India, which exhibited resistance to several beta-lactam antibiotics.
Development of "oligotyping" for characterization and molecular epidemiology of TEM beta-lactamases in members of the family Enterobacteriaceae.
Development of "oligotyping" for characterization and molecular epidemiology of TEM beta-lactamases in members of the family Enterobacteriaceae.
Development of "oligotyping" for characterization and molecular epidemiology of TEM beta-lactamases in members of the family Enterobacteriaceae.
Development of "oligotyping" for characterization and molecular epidemiology of TEM beta-lactamases in members of the family Enterobacteriaceae.
Development of "oligotyping" for characterization and molecular epidemiology of TEM beta-lactamases in members of the family Enterobacteriaceae.
Development of "oligotyping" for characterization and molecular epidemiology of TEM beta-lactamases in members of the family Enterobacteriaceae.
Development of "oligotyping" for characterization and molecular epidemiology of TEM beta-lactamases in members of the family Enterobacteriaceae.
Development of "oligotyping" for characterization and molecular epidemiology of TEM beta-lactamases in members of the family Enterobacteriaceae.
Development of "oligotyping" for characterization and molecular epidemiology of TEM beta-lactamases in members of the family Enterobacteriaceae.
Worldwide diversity of Klebsiella pneumoniae that produce beta-lactamase blaKPC-2 gene.
The study identifies various beta-lactamase genes including blaKPC-2, blaSHV-1, blaSHV-11, blaOKP-A/B, blaTEM-1, blaCTX-M-2, blaCTX-M-12, blaCTX-M-15, and blaOXA-9 in K. pneumoniae isolates from multiple countries, highlighting the diversity and global spread of these resistance genes.
Sequence of pR3521, an IncB plasmid from Escherichia coli encoding ACC-4, SCO-1, and TEM-1 beta-lactamases.
The study presents the complete nucleotide sequence of the IncB plasmid pR3521 from Escherichia coli, which contains three beta-lactamase genes: blaACC-4, blaSCO-1, and blaTEM-1. These genes confer resistance to various beta-lactam antibiotics.
Phenotypic and genotypic characterization of β-lactam resistance in Klebsiella pneumoniae isolated from swine.
Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes.
The study identifies several antimicrobial resistance genes in the plasmid of the adherent-invasive E. coli strain NRG857c, including blaTEM, tetC, tetA, catI, dhfrI, sulII, and sulI, which confer resistance to ampicillin, tetracycline, chloramphenicol, and sulfonamides.
Clinical characteristics of bloodstream infections due to ampicillin-sulbactam-resistant, non-extended- spectrum-beta-lactamase-producing Escherichia coli and the role of TEM-1 hyperproduction.
The study identifies TEM-1 hyperproduction as the primary mechanism of ampicillin-sulbactam resistance in E. coli, with no evidence of inhibitor-resistant TEM (IRT) β-lactamase production.
Molecular epidemiology of Salmonella enterica serovar Typhimurium isolates from cattle in Hokkaido, Japan: evidence of clonal replacement and characterization of the disseminated clone.
The study identified a novel multidrug-resistant Salmonella enterica serovar Typhimurium clone carrying a virulence-resistance plasmid in cattle in Hokkaido, Japan. The clone was characterized by the presence of the blaTEM-1 and blaCMY-2 genes, which confer resistance to ampicillin and cefazolin, respectively.
Chromosome-encoded AmpC and CTX-M extended-spectrum beta-lactamases in clinical isolates of Proteus mirabilis from Korea.
The study identifies several extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase genes, including bla CTX-M-14a, bla CTX-M-90, bla CTX-M-15, bla CTX-M-12, bla CTX-M-2, bla CTX-M-14b, bla TEM-52, bla SHV-12, bla CMY-2, and bla DHA-1, in clinical isolates of Proteus mirabilis from Korea. These genes were found to be responsible for resistance to various β-lactam antibiotics.
Antimicrobial Susceptibility and Multiplex PCR Screening of AmpC Genes From Isolates of Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens.
The study identified ampC genes of DHA, EBC, and CIT types in Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens isolates, along with TEM, CTX-M-3-like, and SHV genes, demonstrating their roles in conferring resistance to various beta-lactam antibiotics.
Antibiotic resistance genes in the bacteriophage DNA fraction of environmental samples.
The study identifies and characterizes the presence of antibiotic resistance genes (blaTEM, blaCTX-M9, and mecA) in bacteriophage DNA from environmental samples, demonstrating their potential to confer resistance when transferred to bacterial hosts.
High prevalence of extended-spectrum beta lactamases among Salmonella enterica Typhimurium isolates from pediatric patients with diarrhea in China.
The study identifies a high prevalence of extended-spectrum beta-lactamases (ESBLs) among Salmonella enterica Typhimurium isolates from pediatric patients in China, including the first report of bla CTX-M-55 in Salmonella spp.
Distribution of the blaTEM gene and blaTEM-containing transposons in commensal Escherichia coli.
Plasmid typing and resistance profiling of Escherichia fergusonii and other Enterobacteriaceae isolates from South Korean farm animals.
The study identified TEM-1, CTXM-15, and DHA-1 beta-lactamase genes in various Enterobacteriaceae isolates from South Korean farm animals, highlighting their role in beta-lactam resistance.
Emergence of NDM-1-producing Enterobacteriaceae in Belgium.
The study reports the emergence of NDM-1-producing Enterobacteriaceae in Belgium, highlighting the presence of multiple resistance mechanisms including blaNDM-1, qnrA6, qnrB1, qnrB2, and various beta-lactamases, rRNA methylases, and quinolone resistance genes.
Antimicrobial resistance, virulence-associated genes, and pulsed-field gel electrophoresis profiles of Salmonella enterica subsp. enterica serovar Typhimurium isolated from piglets with diarrhea in Korea.
The study identified multiple antimicrobial resistance genes in Salmonella enterica subsp. enterica serovar Typhimurium isolates from piglets with diarrhea in Korea, including bla PSE, bla TEM, cat1, cat2, floR, strA, strB, aadA, sulI, sulII, tetA, tetC, and tetG.
Distribution and characterization of ampicillin- and tetracycline-resistant Escherichia coli from feedlot cattle fed subtherapeutic antimicrobials.
The study identified the tetracycline resistance gene tet(B) and the ampicillin resistance gene tem1-like in Escherichia coli isolates from feedlot cattle. These genes were found to confer resistance to tetracycline and ampicillin, respectively.
A multiplex real-time PCR assay targeting virulence and resistance genes in Salmonella enterica serotype Typhimurium.
The study identified the presence of bla TEM and sul1 genes in Salmonella enterica serotype Typhimurium strains, which confer resistance to beta-lactam and sulfonamide antibiotics, respectively.
Acinetobacter baumannii isolates from pets and horses in Switzerland: molecular characterization and clinical data.
The study identified several AMR genes and mutations in Acinetobacter baumannii isolates from pets and horses in Switzerland, including blaOXA-66, blaADC-25, blaTEM-1, aacC2, aadA1, aacC1, IS1133, ISAb1, and mutations in gyrA and parC genes associated with resistance to carbapenems, cephalosporins, piperacillin/tazobactam, gentamicin, and ciprofloxacin.
Analysis of the resistome of a multidrug-resistant NDM-1-producing Escherichia coli strain by high-throughput genome sequencing.
The study identified multiple AMR genes in a multidrug-resistant E. coli strain, including blaNDM-1, blaTEM-1, blaCTX-M-15, and others, along with chromosomal mutations in gyrA, parC, ompC, and ompF contributing to resistance.
Susceptibility of extended-spectrum-beta-lactamase-producing Enterobacteriaceae according to the new CLSI breakpoints.
Susceptibility of extended-spectrum-beta-lactamase-producing Enterobacteriaceae according to the new CLSI breakpoints.
Susceptibility of extended-spectrum-beta-lactamase-producing Enterobacteriaceae according to the new CLSI breakpoints.
Susceptibility of extended-spectrum-beta-lactamase-producing Enterobacteriaceae according to the new CLSI breakpoints.
bla(CTX-M), bla(TEM), and bla(SHV) in Enterobacteriaceae from North-Indian tertiary hospital: high occurrence of combination genes.
The study identified the high occurrence of bla(CTX-M), bla(TEM), and bla(SHV) genes in Enterobacteriaceae from a North-Indian tertiary hospital, highlighting the widespread dissemination of these genes and their combination in clinical isolates.
Emergence of a globally dominant IncHI1 plasmid type associated with multiple drug resistant typhoid.
The study identifies the emergence of a globally dominant IncHI1 plasmid type (PST6) associated with multiple drug-resistant typhoid. Key resistance genes include blaTEM-1, cat, dfrA7, sul1, sul2, strAB, tetA, tetD, and betU, which contribute to resistance against ampicillin, chloramphenicol, trimethoprim, sulfamethoxazole, streptomycin, tetracycline, and high salt environments.
Acquired antibiotic resistance: are we born with it?
The study identified the presence of tetracycline resistance gene tet (M), erythromycin resistance gene ermB, sulfonamide resistance gene sul2, and beta-lactam resistance gene bla TEM in the gut microbiota of infants, indicating that antibiotic resistance genes are present in the human gut microbiota from an early age.
Two novel transferable extended-spectrum beta-lactamases from Klebsiella pneumoniae in Tunisia.
Two novel transferable extended-spectrum beta-lactamases from Klebsiella pneumoniae in Tunisia.
Two novel transferable extended-spectrum beta-lactamases from Klebsiella pneumoniae in Tunisia.
Two novel transferable extended-spectrum beta-lactamases from Klebsiella pneumoniae in Tunisia.
Two novel transferable extended-spectrum beta-lactamases from Klebsiella pneumoniae in Tunisia.
Two novel transferable extended-spectrum beta-lactamases from Klebsiella pneumoniae in Tunisia.
Characterization of multidrug-resistant Escherichia coli isolates from animals presenting at a university veterinary hospital.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from animals, including bla TEM, bla CTX-M-2, bla CMY-2, strA-strB, aadA, aphA1, aadB, cat, floR, sul1, sul2, tet(A), and tet(B). These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, chloramphenicol, sulfonamides, and tetracyclines.
Molecular characterization of multidrug-resistant Escherichia coli isolates from Irish cattle farms.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from Irish cattle farms, including strA-strB, aphA1, aadA, aadB, blaTEM, sul2, tet(A), and tet(B). These genes were associated with resistance to streptomycin, neomycin, kanamycin, spectinomycin, ampicillin, amoxicillin-clavulanic acid, sulfonamides, and tetracycline.
First detection of TEM-116 extended-spectrum beta-lactamase in a Providencia stuartii isolate from a Tunisian hospital.
The study reports the first detection of the TEM-116 extended-spectrum beta-lactamase in a Providencia stuartii isolate from a Tunisian hospital, highlighting its role in resistance to several β-lactam antibiotics.
Comparison of plasmid-mediated quinolone resistance and extended-spectrum β-lactamases in third-generation cephalosporin-resistant Enterobacteriaceae from four Irish hospitals.
Comparison of plasmid-mediated quinolone resistance and extended-spectrum β-lactamases in third-generation cephalosporin-resistant Enterobacteriaceae from four Irish hospitals.
Comparison of plasmid-mediated quinolone resistance and extended-spectrum β-lactamases in third-generation cephalosporin-resistant Enterobacteriaceae from four Irish hospitals.
Biochemical characterization of the TEM-107 extended-spectrum beta-lactamase in a Klebsiella pneumoniae isolate from South Korea.
The study characterizes the TEM-107 extended-spectrum beta-lactamase, which shows increased resistance to ceftazidime compared to cefotaxime in a Klebsiella pneumoniae isolate from South Korea.
Biochemical characterization of the TEM-107 extended-spectrum β-lactamase in a Klebsiella pneumoniae isolate from South Korea.
QRDR mutations, efflux system & antimicrobial resistance genes in enterotoxigenic Escherichia coli isolated from an outbreak of diarrhoea in Ahmedabad, India.
The study identified QRDR mutations in gyrA and parC, as well as the aac(6')-Ib-cr gene, class 1 and class 2 integrons, and various resistance genes including blaTEM-1, catA1, dfrA1, dfrA17, aadA1, aadA5, strA, tet, and aphA1-Ia in ETEC strains, contributing to multidrug resistance.
Detection of betalactamase producing bacterial genes and their clinical features.
The study identified TEM and SHV beta-lactamase genes as the most common drug resistance genes in E. coli and Klebsiella spp. isolates, with TEM being present in 50% of the isolates and SHV in 11%. Coexistence of TEM and SHV was found in 11% of the isolates.
Characterization of Vibrio Parahaemolyticus isolated from oysters and mussels in São Paulo, Brazil.
All 19 V. parahaemolyticus isolates possessed the blaTEM-116 gene, indicating resistance to various beta-lactam antibiotics.
Phenotypic and genotypic characterization of Salmonella enterica recovered from poultry meat in Tunisia and identification of new genetic traits.
The study identified various AMR genes in Salmonella enterica isolates from poultry meat in Tunisia, including blaTEM, aadA1, aadA2, dfrA1, sul1, sul2, sul3, strA-strB, cmlA, and tet(A). These genes contribute to resistance against multiple antibiotics such as ampicillin, sulfonamides, streptomycin, trimethoprim, chloramphenicol, and tetracycline.
Antibiotic resistance in primary and persistent endodontic infections.
The study identified bla TEM-1, cfx A, tet M, tet W, and tet Q as the most prevalent antibiotic resistance genes in endodontic infections. bla TEM-1 was more prevalent in primary infections, while tet M remained unchanged after treatment. Vancomycin resistance genes were not detected.
Molecular characterization of resistance to extended-spectrum cephalosporins in clinical Escherichia coli isolates from companion animals in the United States.
Molecular characterization of resistance to extended-spectrum cephalosporins in clinical Escherichia coli isolates from companion animals in the United States.
Molecular characterization of resistance to extended-spectrum cephalosporins in clinical Escherichia coli isolates from companion animals in the United States.
Network Analysis of TEM beta-lactamase Mutants Reveals Adaptive Evolution Trajectories
The study identifies several mutations in the TEM-1 beta-lactamase gene that enhance resistance to extended-spectrum β-lactams, particularly cefotaxime. These mutations include E104K, R164H, G238S, E240K, M182T, T265M, H153R, I173V, A224V, R120S, K215E, L51P, L40W, and Q39R.
Comparative study on occurrence of class A and class C beta-lactamase genes and their co-occurrence in Indian Enterobacteriaceae during years 2009 and 2010.
The study identified the occurrence and co-occurrence of class A (bla CTX-M, bla SHV, bla TEM) and class C (bla ampC) beta-lactamase genes in Indian Enterobacteriaceae isolates, highlighting a decrease in the co-existence of bla ESBLs with bla ampC from 2009 to 2010.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
An insight into the drug resistance profile & mechanism of drug resistance in Neisseria gonorrhoeae.
The study identifies blaTEM-1 as a plasmid-encoded beta-lactamase conferring penicillin resistance in Neisseria gonorrhoeae and highlights gyrA mutations as a key mechanism for fluoroquinolone resistance.
Inactivation of a class A and a class C beta-lactamase by 6β-(hydroxymethyl)penicillanic acid sulfone.
The study characterizes the effectiveness of 6β-HM-sulfone as an inhibitor of the class A beta-lactamase TEM-1 and the class C beta-lactamase PDC-3, showing significant inactivation of these enzymes and enhancing the efficacy of ampicillin against resistant strains.
Prevalence of plasmid mediated bla(TEM-1) and bla(CTX-M-15) type extended spectrum beta-lactamases in patients with sepsis.
The study identified bla(TEM-1) and bla(CTX-M-15) genes in Escherichia coli isolates from patients with sepsis, highlighting their role in antimicrobial resistance.
Clinical and Microbiologic Characteristics of Cephalosporin-Resistant Escherichia coli at Three Centers in the United States.
The study identified CTX-M-15 as the most common ESBL in cephalosporin-resistant E. coli, followed by CMY-2, SHV, TEM, and KPC beta-lactamases. These genes confer resistance to various beta-lactam antibiotics.
Mechanisms of resistance and clinical relevance of resistance to β-lactams, glycopeptides, and fluoroquinolones.
The paper discusses the mechanisms of resistance to β-lactams, glycopeptides, and fluoroquinolones, highlighting the role of beta-lactamases such as TEM, SHV, CTX-M, KPC, VIM, and NDM, glycopeptide resistance operons like vanA and vanB, and other resistance genes such as ermB, mecA, qnrA, and aac(6')-Ib.
Incidence of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in patients with urinary tract infection.
The study identified blaSHV, blaTEM, and blaCTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) production in Klebsiella pneumoniae isolates from urinary tract infections in Iran.
Occurrence and characteristics of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae in food producing animals, minced meat and raw milk.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including CTX-M-1, CTX-M-14, CTX-M-15, CTX-M-117, CTX-M-186, SHV-12, TEM-1, and TEM-52, in Enterobacteriaceae isolated from food-producing animals, minced meat, and raw milk in Switzerland.
Occurrence and characteristics of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae in food producing animals, minced meat and raw milk.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including CTX-M-1, CTX-M-14, CTX-M-15, CTX-M-117, CTX-M-186, SHV-12, TEM-1, and TEM-52, in Enterobacteriaceae isolated from food-producing animals, minced meat, and raw milk in Switzerland.
Occurrence and characteristics of extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae in food producing animals, minced meat and raw milk.
Occurrence and characteristics of extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae in food producing animals, minced meat and raw milk.
Occurrence and characteristics of extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae in food producing animals, minced meat and raw milk.
Multidrug-resistant Proteus mirabilis bloodstream infections: risk factors and outcomes.
The study identifies several TEM-type beta-lactamase genes (bla TEM-52, bla TEM-11, bla TEM-72, bla TEM-93, and bla TEM-111) in multidrug-resistant Proteus mirabilis isolates causing bloodstream infections, which confer resistance to various beta-lactam antibiotics.
Multidrug-resistant Proteus mirabilis bloodstream infections: risk factors and outcomes.
The study identifies several TEM-type beta-lactamase genes (bla TEM-52, bla TEM-11, bla TEM-72, bla TEM-93, and bla TEM-111) in multidrug-resistant Proteus mirabilis isolates causing bloodstream infections, which confer resistance to various beta-lactam antibiotics.
Multidrug-resistant Proteus mirabilis bloodstream infections: risk factors and outcomes.
The study identifies several TEM-type beta-lactamase genes (bla TEM-52, bla TEM-11, bla TEM-72, bla TEM-93, and bla TEM-111) in multidrug-resistant Proteus mirabilis isolates causing bloodstream infections, which confer resistance to various beta-lactam antibiotics.
Multidrug-resistant Proteus mirabilis bloodstream infections: risk factors and outcomes.
The study identifies several TEM-type beta-lactamase genes (bla TEM-52, bla TEM-11, bla TEM-72, bla TEM-93, and bla TEM-111) in multidrug-resistant Proteus mirabilis isolates causing bloodstream infections, which confer resistance to various beta-lactam antibiotics.
Multidrug-resistant Proteus mirabilis bloodstream infections: risk factors and outcomes.
The study identifies several TEM-type beta-lactamase genes (bla TEM-52, bla TEM-11, bla TEM-72, bla TEM-93, and bla TEM-111) in multidrug-resistant Proteus mirabilis isolates causing bloodstream infections, which confer resistance to various beta-lactam antibiotics.
Multidrug-resistant Proteus mirabilis bloodstream infections: risk factors and outcomes.
Multidrug-resistant Proteus mirabilis bloodstream infections: risk factors and outcomes.
Multidrug-resistant Proteus mirabilis bloodstream infections: risk factors and outcomes.
Spanish multicenter study of the epidemiology and mechanisms of amoxicillin-clavulanate resistance in Escherichia coli.
Spanish multicenter study of the epidemiology and mechanisms of amoxicillin-clavulanate resistance in Escherichia coli.
Spanish multicenter study of the epidemiology and mechanisms of amoxicillin-clavulanate resistance in Escherichia coli.
Shiga toxin-producing Escherichia coli O104:H4: a new challenge for microbiology.
The study characterizes the resistance genes TEM-1 and CTX-M-15 in the E. coli O104:H4 strain, which conferred resistance to penicillins and cephalosporins.
Current epidemiology and growing resistance of gram-negative pathogens.
The paper highlights the emergence and spread of multidrug-resistant Gram-negative pathogens, focusing on extended-spectrum beta-lactamases (ESBLs) such as CTX-M-15 and CTX-M-14, carbapenemases like KPC-2, VIM-2, and IMP-6, and aminoglycoside-modifying enzymes such as aac(6')-Ib-cr and armA. It emphasizes the global dissemination of these resistance mechanisms and their impact on treatment options.
Transmission dynamics of extended-spectrum β-lactamase-producing Enterobacteriaceae in the tertiary care hospital and the household setting.
Transmission dynamics of extended-spectrum β-lactamase-producing Enterobacteriaceae in the tertiary care hospital and the household setting.
Transmission dynamics of extended-spectrum β-lactamase-producing Enterobacteriaceae in the tertiary care hospital and the household setting.
Transmission dynamics of extended-spectrum β-lactamase-producing Enterobacteriaceae in the tertiary care hospital and the household setting.
Molecular epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli in the community and hospital in Korea: emergence of ST131 producing CTX-M-15.
The study identified CTX-M-14 and CTX-M-15 as the predominant extended-spectrum beta-lactamases (ESBLs) in Escherichia coli isolates from both community and hospital settings in Korea. The ST131 clone was found to be the most prevalent and was significantly associated with CTX-M-15 production, contributing to multidrug resistance.
Catheter-related bacteremia caused by multidrug-resistant Leclercia adecarboxylata in a patient with breast cancer.
The study reports a multidrug-resistant strain of Leclercia adecarboxylata causing catheter-related bacteremia in a patient with breast cancer, harboring bla TEM-1, bla CTX-M group 1, and intl1 genes.
Evolutionary paths to antibiotic resistance under dynamically sustained drug selection
The study identifies 48 beneficial mutations in the TEM-1 beta-lactamase enzyme that increase resistance to cefotaxime (Ctx). These mutations are distributed across the enzyme's structure, with a significant portion located near the catalytic site. The distribution of resistance effects follows a Fréchet-type distribution, indicating a heavy tail with a few mutations having exceptionally large effects.
First description of Escherichia coli producing CTX-M-15- extended spectrum beta lactamase (ESBL) in out-patients from south eastern Nigeria.
The study reports the first description of Escherichia coli producing CTX-M-15 extended spectrum beta lactamase in out-patients from South-eastern Nigeria. It identifies bla CTX-M-15, aac(6')-Ib-cr, bla TEM, and bla OXA-1 as the primary AMR genes in the isolates.
Commensal Pseudomonas species isolated from wastewater and freshwater milieus in the Eastern Cape Province, South Africa, as reservoir of antibiotic resistant determinants.
The study identified the blaTEM gene in various Pseudomonas species, indicating their potential as reservoirs of antibiotic resistance genes.
Characterization of extended-spectrum beta-lactamase-producing Salmonella enterica serotype Brunei and Heidelberg at the Hussein Dey hospital in Algiers (Algeria).
Characterization of extended-spectrum beta-lactamase-producing Salmonella enterica serotype Brunei and Heidelberg at the Hussein Dey hospital in Algiers (Algeria).
Characterization of extended-spectrum beta-lactamase-producing Salmonella enterica serotype Brunei and Heidelberg at the Hussein Dey hospital in Algiers (Algeria).
Characterization of extended-spectrum beta-lactamase-producing Salmonella enterica serotype Brunei and Heidelberg at the Hussein Dey hospital in Algiers (Algeria).
Increased frequency of integrons and beta-lactamase-coding genes among extraintestinal Escherichia coli isolated with a 7-year interval.
The study identified an increase in the frequency of integrons and beta-lactamase-coding genes, particularly bla CTX-M-1, bla CTX-M-3, bla CTX-M-15, bla CTX-M-55, bla TEM-1, bla OXA-1, bla SHV-1, bla SHV-12, bla CMY-15, and bla DHA, in extraintestinal Escherichia coli strains isolated over a 7-year period.
CTX-M-producing Escherichia coli and Klebsiella pneumoniae isolated from community-acquired urinary tract infections in Valledupar, Colombia.
The study identified CTX-M-1, TEM, SHV, and CMY-2 beta-lactamase genes in E. coli and K. pneumoniae isolates from community-acquired UTIs in Colombia, highlighting the presence of multidrug-resistant strains.
Deep sequencing of systematic combinatorial libraries reveals beta-lactamase sequence constraints at high resolution.
The study characterizes the sequence constraints of the TEM-1 beta-lactamase enzyme through deep sequencing of combinatorial libraries, identifying specific amino acid substitutions that affect enzyme stability and ampicillin resistance.
Multiresistant uropathogenic Escherichia coli from a region in India where urinary tract infections are endemic: genotypic and phenotypic characteristics of sequence type 131 isolates of the CTX-M-15 extended-spectrum-β-lactamase-producing lineage.
The study identifies the CTX-M-15 extended-spectrum beta-lactamase and other resistance genes such as aac(6')-Ib-cr, blaOXA-1, and blaTEM-1 in multidrug-resistant ST131 E. coli isolates from India.
A binational cohort study of intestinal colonization with extended-spectrum β-lactamase-producing Proteus mirabilis in patients admitted to rehabilitation centres.
A binational cohort study of intestinal colonization with extended-spectrum β-lactamase-producing Proteus mirabilis in patients admitted to rehabilitation centres.
A binational cohort study of intestinal colonization with extended-spectrum β-lactamase-producing Proteus mirabilis in patients admitted to rehabilitation centres.
A binational cohort study of intestinal colonization with extended-spectrum β-lactamase-producing Proteus mirabilis in patients admitted to rehabilitation centres.
Population distribution of Beta-lactamase conferring resistance to third-generation cephalosporins in human clinical Enterobacteriaceae in the Netherlands.
The study identifies bla CTX-M-15 as the most prevalent ESBL gene in third-generation cephalosporin-resistant Enterobacteriaceae in the Netherlands, along with various other ESBL and AmpC genes such as bla CTX-M-1, bla CTX-M-14, bla SHV-12, bla TEM-52, and bla CMY-2. Mutations in the promoter region of the chromosomal ampC gene were also found to contribute to resistance.
Novel mechanisms of resistance to β-lactam antibiotics in Haemophilus parainfluenzae: β-lactamase-negative ampicillin resistance and inhibitor-resistant TEM β-lactamases.
Novel mechanisms of resistance to β-lactam antibiotics in Haemophilus parainfluenzae: β-lactamase-negative ampicillin resistance and inhibitor-resistant TEM β-lactamases.
Novel mechanisms of resistance to β-lactam antibiotics in Haemophilus parainfluenzae: β-lactamase-negative ampicillin resistance and inhibitor-resistant TEM β-lactamases.
Novel mechanisms of resistance to β-lactam antibiotics in Haemophilus parainfluenzae: β-lactamase-negative ampicillin resistance and inhibitor-resistant TEM β-lactamases.
Novel mechanisms of resistance to β-lactam antibiotics in Haemophilus parainfluenzae: β-lactamase-negative ampicillin resistance and inhibitor-resistant TEM β-lactamases.
TEM-187, a new extended-spectrum beta-lactamase with weak activity in a Proteus mirabilis clinical strain.
The study identifies TEM-187, a novel extended-spectrum beta-lactamase with weak activity in a Proteus mirabilis clinical strain, highlighting challenges in detecting such variants due to low MICs and the need for improved detection methods.
TEM-187, a new extended-spectrum β-lactamase with weak activity in a Proteus mirabilis clinical strain.
TEM-187, a new extended-spectrum β-lactamase with weak activity in a Proteus mirabilis clinical strain.
TEM-187, a new extended-spectrum β-lactamase with weak activity in a Proteus mirabilis clinical strain.
TEM-187, a new extended-spectrum β-lactamase with weak activity in a Proteus mirabilis clinical strain.
Prevalence and Molecular Characterization of Plasmid-mediated Extended-Spectrum β-Lactamase Genes (balaTEM, blaCTX and blASHV) Among Urinary Escherichia coli Clinical Isolates in Mashhad, Iran.
The study identified the prevalence of plasmid-mediated extended-spectrum beta-lactamase (ESBL) genes blaCTX, blaTEM, and blaSHV among urinary Escherichia coli isolates in Mashhad, Iran. blaCTX was the most prevalent gene, followed by blaTEM and blaSHV.
Comparative genomic analysis of rapid evolution of an extreme-drug-resistant Acinetobacter baumannii clone.
The study identifies multiple AMR genes and mutations in the EDR A. baumannii 53264 strain, including aac(6')-Iaf, aac(3)-Ia, aph(3')-Ia, aph(3')-Ic, strA/aph(3'')-Ib, blaOXA-23, blaTEM-1, sul1, sul3, and tet(B). Additionally, mutations in ampC, gyrB, parC, and qseC contribute to resistance against various antibiotics.
Antimicrobial resistance, virulence factors and genetic diversity of Escherichia coli isolates from household water supply in Dhaka, Bangladesh.
The study identified several AMR genes in E. coli isolates from household water in Dhaka, including bla CTX-M-15, bla CTX-M-1-group, bla TEM, bla OXA-1-group, bla OXA-47, qnrS, qnrB, and bla CMY-2. These genes conferred resistance to multiple antibiotics, highlighting the presence of multidrug-resistant E. coli in the water supply.
Commensal Enterobacteriaceae as reservoirs of extended-spectrum beta-lactamases, integrons, and sul genes in Portugal.
The study identifies blaCTX-M-14 and blaTEM-153 as extended-spectrum beta-lactamases in commensal Enterobacteriaceae in Portugal, along with sul1, sul2, and sul3 as sulfonamide resistance genes. These genes are part of mobile genetic elements such as integrons and plasmids, highlighting the role of commensal flora as a reservoir of clinically relevant antibiotic resistance genes.
Commensal Enterobacteriaceae as reservoirs of extended-spectrum beta-lactamases, integrons, and sul genes in Portugal.
Commensal Enterobacteriaceae as reservoirs of extended-spectrum beta-lactamases, integrons, and sul genes in Portugal.
Commensal Enterobacteriaceae as reservoirs of extended-spectrum beta-lactamases, integrons, and sul genes in Portugal.
Commensal Enterobacteriaceae as reservoirs of extended-spectrum beta-lactamases, integrons, and sul genes in Portugal.
Molecular characterization of multidrug-resistant extended-spectrum beta-lactamase-producing Enterobacteriaceae isolated in Antananarivo, Madagascar.
The study identified bla CTX-M-15 and bla SHV-12 as the predominant ESBL genes in multidrug-resistant Enterobacteriaceae isolates in Antananarivo, along with other resistance genes such as aac(6')-Ib, tetA, sul1, sul2, qnrA, qnrB, and catB-3.
Molecular characterization and drug resistance of Escherichia coli strains isolated from urine from long-term care facility residents in Cracow, Poland.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-3, bla TEM-1, and bla SHV-12, in Escherichia coli isolates from long-term care facility residents in Poland.
Frequency and factors associated with carriage of multi-drug resistant commensal Escherichia coli among women attending antenatal clinics in central India.
The study identified bla CTX-M-15, bla TEM-1, and aac(6′)-Ib-cr genes as major contributors to multidrug resistance in commensal E. coli from antenatal women in India. Chromosomal mutations in gyrA (D87N/S83L) and parC (S80l) were also linked to quinolone resistance.
Genetic characterization of antimicrobial resistance of Shigella flexneri 1c isolates from patients in Egypt and Pakistan.
The study identified bla TEM, bla OXA, and sul II genes as key contributors to antimicrobial resistance in Shigella flexneri 1c isolates from Egypt and Pakistan.
Prevalence and types of extended spectrum β-lactamases among urinary Escherichia coli isolates in Moroccan community.
Prevalence and types of extended spectrum β-lactamases among urinary Escherichia coli isolates in Moroccan community.
Prevalence and types of extended spectrum β-lactamases among urinary Escherichia coli isolates in Moroccan community.
Prevalence and types of extended spectrum β-lactamases among urinary Escherichia coli isolates in Moroccan community.
Prevalence and types of extended spectrum β-lactamases among urinary Escherichia coli isolates in Moroccan community.
Prevalence and types of extended spectrum β-lactamases among urinary Escherichia coli isolates in Moroccan community.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
The study identified various AMR genes and mutations in E. coli and K. pneumoniae isolates, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-15), aminoglycoside-modifying enzymes (aac(6')-Ib-cr, aadA1a, aadA4, aadA5, aph(6')-Id, aph(3')-Ia), and quinolone resistance mutations (gyrA S83L/D87N, parC S80I/E84V). These genes and mutations were validated through whole-genome sequencing and phenotypic testing.
Cross-sectional study on prevalence and molecular characteristics of plasmid mediated ESBL/AmpC-producing Escherichia coli isolated from veal calves at slaughter.
The study identified bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and other bla CTX-M variants as the major genes responsible for plasmid-mediated resistance to cefotaxime in E. coli from veal calves. Additionally, aac(6')-Ib-cr was found to confer resistance to aminoglycosides and fluoroquinolones.
Cross-sectional study on prevalence and molecular characteristics of plasmid mediated ESBL/AmpC-producing Escherichia coli isolated from veal calves at slaughter.
The study identified bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and other bla CTX-M variants as the major genes responsible for plasmid-mediated resistance to cefotaxime in E. coli from veal calves. Additionally, aac(6')-Ib-cr was found to confer resistance to aminoglycosides and fluoroquinolones.
Cross-sectional study on prevalence and molecular characteristics of plasmid mediated ESBL/AmpC-producing Escherichia coli isolated from veal calves at slaughter.
The study identified bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and other bla CTX-M variants as the major genes responsible for plasmid-mediated resistance to cefotaxime in E. coli from veal calves. Additionally, aac(6')-Ib-cr was found to confer resistance to aminoglycosides and fluoroquinolones.
Cross-sectional study on prevalence and molecular characteristics of plasmid mediated ESBL/AmpC-producing Escherichia coli isolated from veal calves at slaughter.
The study identified bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and other bla CTX-M variants as the major genes responsible for plasmid-mediated resistance to cefotaxime in E. coli from veal calves. Additionally, aac(6')-Ib-cr was found to confer resistance to aminoglycosides and fluoroquinolones.
Chronological Change of Resistance to β-Lactams in Salmonella enterica serovar Infantis Isolated from Broilers in Japan.
The study identified the emergence of Salmonella enterica serovar Infantis isolates carrying blaTEM-52, blaTEM-20, blaCTX-M-25, and blaCMY-2 genes, which confer resistance to extended-spectrum cephalosporins and other beta-lactams. Additionally, non-beta-lactam resistance genes such as aadA1, sul1, tet(A), and aphA1-Iab were prevalent.
Chronological Change of Resistance to β-Lactams in Salmonella enterica serovar Infantis Isolated from Broilers in Japan.
The study identified the emergence of Salmonella enterica serovar Infantis isolates carrying blaTEM-52, blaTEM-20, blaCTX-M-25, and blaCMY-2 genes, which confer resistance to extended-spectrum cephalosporins and other beta-lactams. Additionally, non-beta-lactam resistance genes such as aadA1, sul1, tet(A), and aphA1-Iab were prevalent.
Genetic mechanisms of antimicrobial resistance identified in Salmonella enterica, Escherichia coli, and Enteroccocus spp. isolated from U.S. food animals.
The study identifies various AMR genes in Salmonella enterica, Escherichia coli, and Enterococcus spp. isolated from U.S. food animals, including aac(3'), aac(6'), aadA, aadA1, aadA2, aadA12, aphAI, aph(3')-Ii-iv, strA, strB, bla CMY-2, bla TEM-1, bla PSE-1, floR, cmlA, cat1, cat2, sul1, sul2, dfr1, dfrA10, tet(A), tet(B), tet(C), tet(D), tet(G), and tetR.
Presence of multi-drug resistant pathogenic Escherichia coli in the San Pedro River located in the State of Aguascalientes, Mexico.
The study identified multiple antimicrobial resistance genes and mutations in E. coli isolates from the San Pedro River, including blaTEM, qnrS, aac(6')-Ib-cr, and tet(B), as well as mutations in gyrA and parC contributing to quinolone resistance.
Affect of anaerobiosis on the antibiotic susceptibility of H. influenzae
The study found that the TEM beta-lactamase gene was present in some strains of H. influenzae, conferring resistance to ampicillin, but these strains were susceptible to cefaclor and cefuroxime.
Detection of beta-lactamase residues in milk by sandwich ELISA.
The study developed a sandwich ELISA for detecting beta-lactamase residues in milk using monoclonal antibodies against TEM-1 beta-lactamase.
beta-lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula.
The study identifies various beta-lactamase genes, including CTX-M-15, CTX-M-14, CTX-M-9, SHV-12, SHV-5, TEM-1, VEB-1, GES-1, GES-5, GES-11, PER-1, OXA-48, NDM-1, VIM-2, OXA-23, OXA-40, OXA-58, and OXA-181, which confer resistance to β-lactam antibiotics in Gram-negative pathogens from the Arabian Peninsula.
The occurrence of extended-spectrum beta-lactamase producing Shigella spp. in Tehran, Iran.
The study identified ESBL-producing Shigella isolates, including S. sonnei and S. flexneri, carrying bla TEM-1, bla CTX-M-15, and bla CMY-59 genes, highlighting the emergence of multidrug-resistant strains in Tehran, Iran.
A simple multiplex PCR for assessing prevalence of extended-spectrum β-lactamases producing Klebsiella pneumoniae in Intensive Care Units of a referral hospital in Shiraz, Iran.
The study identified the prevalence of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae in ICU patients, highlighting the significance of bla_TEM, bla_SHV, and bla_CTX-M genes in conferring resistance to ampicillin.
TEM-1 β-lactamase as a source of resistance to sulbactam in clinical strains of Acinetobacter baumannii.
Impact of manure fertilization on the abundance of antibiotic-resistant bacteria and frequency of detection of antibiotic resistance genes in soil and on vegetables at harvest.
The study identified several antibiotic resistance genes in soil and on vegetables, including genes conferring resistance to tetracycline, aminoglycosides, erythromycin, sulfamethoxazole, and beta-lactams. The presence of these genes was influenced by manure fertilization, with certain genes more frequently detected in manured soils.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
Detection of Escherichia coli and associated β-lactamases genes from diabetic foot ulcers by multiplex PCR and molecular modeling and docking of SHV-1, TEM-1, and OXA-1 β-lactamases with clindamycin and piperacillin-tazobactam.
The study identified bla TEM-1, bla SHV-1, bla OXA-1, and bla CTX-M-15 genes in E. coli isolates from diabetic foot ulcers, which confer resistance to multiple beta-lactam antibiotics.
Horizontol dissemination of TEM- and SHV-typr beta-lactamase genes-carrying resistance plasmids amongst clonical isolates of Enterobacteriaceae.
The study identifies the horizontal dissemination of TEM- and SHV-type beta-lactamase genes carried by resistance plasmids among clinical isolates of Enterobacteriaceae, highlighting the role of conjugative plasmids in the spread of multidrug resistance.
Characterization of class 1 integrons and antibiotic resistance genes in multidrug-resistant Salmonella enterica isolates from foodstuff and related sources.
The study identified several AMR genes, including aadA, sul1, sul2, tetA, blaTEM-1, and qacEAI, associated with resistance to streptomycin, sulfamethoxazole-trimethoprim, tetracycline, ampicillin, and quaternary ammonium compounds, respectively. A mutation in the gyrA gene (Ser83Phe) was linked to resistance to nalidixic acid and enrofloxacin.
Extended-spectrum beta-lactamase-producing bacteria isolated from hematologic patients in Manaus, State of Amazonas, Brazil.
The study identified ESBL-producing bacteria carrying bla TEM, bla SHV, bla CTX-M, and bla OXA genes, which confer resistance to various beta-lactam antibiotics in hematologic patients in Manaus, Brazil.
Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis β-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of β-lactam–β-lactamase inhibitor combinations.
Substitutions in the Mycobacterium tuberculosis β-lactamase BlaC, particularly R220A, R220S, A244R, S130G, T237A, and T237S, were found to reduce the effectiveness of clavulanate, although the wild-type BlaC remains susceptible to ampicillin-clavulanate.
Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India. J. Med. Microbiol.
The study identified several AMR genes including blaTEM-1, aac(6')-Ib, and tet(A) in multidrug-resistant Shigella species isolated from shigellosis cases in India.
Phenotypic and Genotypic Methods for Detection of Extended Spectrum β Lactamase Producing Escherichia coli and Klebsiella pneumoniae Isolated from Ventilator Associated Pneumonia.
The study identified blaCTX-M, blaSHV, and blaTEM genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) production in Escherichia coli and Klebsiella pneumoniae isolates from ventilator-associated pneumonia cases.
Occurrence and distribution of antibiotic-resistant bacteria and transfer of resistance genes in Lake Taihu.
The study identified various beta-lactamase genes (blaTEM, blaSHV, blaCTXM, blaOXA-1) and the intI integron gene in antibiotic-resistant bacteria from Lake Taihu, highlighting the prevalence of ampicillin resistance and the role of horizontal gene transfer in the dissemination of resistance.
Presence of ESBL/AmpC-producing Escherichia coli in the broiler production pyramid: a descriptive study.
The study identified several ESBL/AmpC genes including bla CMY-2, bla TEM-52, bla TEM-52c, bla CTX-M-1, and bla CTX-M-2 in ESBL/AmpC-producing E. coli isolates from various levels of the broiler production pyramid.
Presence of ESBL/AmpC-producing Escherichia coli in the broiler production pyramid: a descriptive study.
The study identified several ESBL/AmpC genes including bla CMY-2, bla TEM-52, bla TEM-52c, bla CTX-M-1, and bla CTX-M-2 in ESBL/AmpC-producing E. coli isolates from various levels of the broiler production pyramid.
Detection and molecular characterization of Escherichia coli CTX-M-15 and Klebsiella pneumoniae SHV-12 beta-lactamases from bovine mastitis isolates in the United Kingdom.
The study identified the presence of CTX-M-15 and SHV-12 beta-lactamases in Escherichia coli and Klebsiella pneumoniae subsp. pneumoniae isolates from bovine mastitis in the United Kingdom, highlighting the role of these enzymes in conferring resistance to various β-lactam antibiotics.
Molecular characterization and in silico analysis of naturally occurring TEM beta-lactamase variants among pathogenic Enterobacteriaceae infecting Indian patients.
The study identified several TEM beta-lactamase variants, including bla TEM-1, bla TEM-1 like, bla TEM-116, bla TEM-169, bla TEM-190, and bla TEM-33, which contribute to third-generation cephalosporin resistance in Enterobacteriaceae isolates from Indian patients.
Molecular characterization and in silico analysis of naturally occurring TEM beta-lactamase variants among pathogenic Enterobacteriaceae infecting Indian patients.
The study identified several TEM beta-lactamase variants, including bla TEM-1, bla TEM-1 like, bla TEM-116, bla TEM-169, bla TEM-190, and bla TEM-33, which contribute to third-generation cephalosporin resistance in Enterobacteriaceae isolates from Indian patients.
Molecular characterization and in silico analysis of naturally occurring TEM beta-lactamase variants among pathogenic Enterobacteriaceae infecting Indian patients.
The study identified several TEM beta-lactamase variants, including bla TEM-1, bla TEM-1 like, bla TEM-116, bla TEM-169, bla TEM-190, and bla TEM-33, which contribute to third-generation cephalosporin resistance in Enterobacteriaceae isolates from Indian patients.
Molecular characterization and in silico analysis of naturally occurring TEM beta-lactamase variants among pathogenic Enterobacteriaceae infecting Indian patients.
The study identified several TEM beta-lactamase variants, including bla TEM-1, bla TEM-1 like, bla TEM-116, bla TEM-169, bla TEM-190, and bla TEM-33, which contribute to third-generation cephalosporin resistance in Enterobacteriaceae isolates from Indian patients.
Molecular characterization and in silico analysis of naturally occurring TEM beta-lactamase variants among pathogenic Enterobacteriaceae infecting Indian patients.
The study identified several TEM beta-lactamase variants, including bla TEM-1, bla TEM-1 like, bla TEM-116, bla TEM-169, bla TEM-190, and bla TEM-33, which contribute to third-generation cephalosporin resistance in Enterobacteriaceae isolates from Indian patients.
Molecular characterization and in silico analysis of naturally occurring TEM beta-lactamase variants among pathogenic Enterobacteriaceae infecting Indian patients.
The study identified several TEM beta-lactamase variants, including bla TEM-1, bla TEM-1 like, bla TEM-116, bla TEM-169, bla TEM-190, and bla TEM-33, which contribute to third-generation cephalosporin resistance in Enterobacteriaceae isolates from Indian patients.
Extended-spectrum beta-lactamase-producing enterobacteriaceae in community-acquired urinary tract infections in São Luís, Brazil.
The study identified blaTEM and blaCTX-M genes as the primary mechanisms of extended-spectrum beta-lactamase (ESBL) production in Enterobacteriaceae causing community-acquired urinary tract infections in São Luís, Brazil. These genes conferred resistance to several β-lactam antibiotics.
Comparison of ESBL--and AmpC producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureus (MRSA) isolated from migratory and resident population of rooks (Corvus frugilegus) in Austria.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-3, bla CTX-M-15, bla TEM-1, bla TEM-15, bla OXA-1, and bla CMY-2, in Enterobacteriaceae isolates from rooks. These genes conferred resistance to cephalosporins such as cefotaxime and ceftazidime.
Comparison of ESBL--and AmpC producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureus (MRSA) isolated from migratory and resident population of rooks (Corvus frugilegus) in Austria.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-3, bla CTX-M-15, bla TEM-1, bla TEM-15, bla OXA-1, and bla CMY-2, in Enterobacteriaceae isolates from rooks. These genes conferred resistance to cephalosporins such as cefotaxime and ceftazidime.
Molecular characteristics of extended-spectrum beta-lactamase-producing Escherichia coli in Riyadh: emergence of CTX-M-15-producing E. coli ST131.
The study identified CTX-M-15 and CTX-M-27 beta-lactamases as the primary extended-spectrum beta-lactamases in E. coli isolates from Riyadh, Saudi Arabia. Additionally, the ST131 clone was found to be prevalent among CTX-M-15-producing E. coli.
PCR-Based Detection of Extended-Spectrum β-Lactamases (bla CTX-M-1 and bla TEM ) in Escherichia coli, Salmonella spp. and Klebsiella pneumoniae Isolated from Pigs in North Eastern India (Mizoram).
The study identified the presence of blaCTX-M-1 and blaTEM genes in Escherichia coli isolates from pigs in Mizoram, India, indicating the occurrence of extended-spectrum beta-lactamases (ESBLs) in livestock.
NDM-1 Metallo-β-Lactamase and ArmA 16S rRNA methylase producing Providencia rettgeri clinical isolates in Nepal.
The study identifies multidrug-resistant Providencia rettgeri clinical isolates in Nepal carrying bla NDM-1, bla OXA-72, and armA genes, which confer resistance to carbapenems and aminoglycosides.
A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and β-lactam resistance genes in the gut microbiota.
The study identified numerous aminoglycoside and β-lactam resistance gene homologues in the gut microbiota of healthy adults, indicating that the human gut microbiota serves as a reservoir for antibiotic resistance genes even in the absence of recent antibiotic exposure.
A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and β-lactam resistance genes in the gut microbiota.
A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and β-lactam resistance genes in the gut microbiota.
A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and β-lactam resistance genes in the gut microbiota.
A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and β-lactam resistance genes in the gut microbiota.
A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and β-lactam resistance genes in the gut microbiota.
A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and β-lactam resistance genes in the gut microbiota.
Modified CLSI extended-spectrum beta-lactamase (ESBL) confirmatory test for phenotypic detection of ESBLs among Enterobacteriaceae producing various beta-lactamases.
The study evaluated a modified CLSI ESBL confirmatory test for the phenotypic detection of extended-spectrum beta-lactamases (ESBLs) among Enterobacteriaceae producing various beta-lactamases, including KPC, VIM, NDM, and OXA-48. The modified test significantly improved the sensitivity and specificity of ESBL detection compared to the standard CLSI test.
Diversity of plasmids encoding resistance and virulence functions in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variant 4,[5],12:i:- strains circulating in Europe.
The study identifies various AMR genes in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variant 4,[5],12:i:- strains, including aac(3)-IV, bla TEM-1, cmlA1, aadA1, aadA2, strA, sul1, sul2, sul3, tet(A), tet(B), and dfrA12, which confer resistance to multiple antibiotics.
Genetic and phenotypic characterisation of Escherichia coli producing cefotaximase-type extended-spectrum β-lactamases: first evidence of the ST131 clone in cats with urinary infections in Italy.
The study identified CTX-M-1, CTX-M-14, and CTX-M-15 beta-lactamase genes in Escherichia coli isolates from cats with urinary tract infections, highlighting the presence of multidrug-resistant strains and the ST131 clone in Italy.
Isolation of Escherichia coli strains with AcrAB-TolC efflux pump-associated intermediate interpretation or resistance to fluoroquinolone, chloramphenicol and aminopenicillin from dogs admitted to a university veterinary hospital.
The study identified blaTEM-1 and catA1 as key resistance genes in E. coli isolates from dogs, along with QRDR mutations in gyrA and parC contributing to fluoroquinolone resistance.
Molecular characterization of ESBL-producing Enterobacteriaceae in northern Portugal.
Molecular characterization of ESBL-producing Enterobacteriaceae in northern Portugal.
Molecular characterization of ESBL-producing Enterobacteriaceae in northern Portugal.
Phenotypic and molecular characterization of multidrug resistant Klebsiella pneumoniae isolated from a university teaching hospital, China.
The study identified multiple AMR genes in multidrug-resistant Klebsiella pneumoniae isolates, including bla TEM, bla CTX-M, bla DHA, and bla KPC, which contribute to resistance against various antibiotics.
Successful control of a neonatal outbreak caused mainly by ST20 multidrug-resistant SHV-5-producing Klebsiella pneumoniae, Greece.
The study reports on an outbreak of multidrug-resistant SHV-5-producing Klebsiella pneumoniae (ST20) in a neonatal intensive care unit in Greece. SHV-5 and TEM-1 beta-lactamases were identified as the primary mechanisms of resistance.
Extended-spectrum beta-lactamases in Escherichia coli and Klebsiella pneumoniae in Gulls, Alaska, USA.
The study identified the presence of extended-spectrum beta-lactamases (ESBLs) in Escherichia coli and Klebsiella pneumoniae isolates from gulls in Alaska, including bla CTX-M, bla SHV, and bla TEM genes.
Characterization of multidrug-resistant Salmonella enterica serovars Indiana and Enteritidis from chickens in Eastern China.
The study identified multiple AMR genes including blaTEM, floR, tetA, strA, and aac(6')-Ib-cr in multidrug-resistant Salmonella enterica serovars Indiana and Enteritidis from chickens in Eastern China.
Characterization of multi-antibiotic-resistant Escherichia coli Isolated from beef cattle in Japan.
The study identified multiple AMR genes in E. coli isolates from beef cattle in Japan, highlighting the diversity of resistance mechanisms and the potential for horizontal gene transfer.
Toxin production and antibiotic resistances in Escherichia coli isolated from bathing areas along the coastline of the Oslo fjord.
The study identified blaTEM genes as the most common resistance determinants in E. coli isolates from the Oslo fjord, conferring resistance to ampicillin.
Persistence of antibiotic-resistant and -sensitive Proteus mirabilis strains in the digestive tract of the housefly (Musca domestica) and green bottle flies (Calliphoridae).
The study identified bla TEM and aph A1 genes in an antibiotic-resistant Proteus mirabilis strain and a qnr D gene in a plasmid of another resistant strain, demonstrating their roles in conferring resistance to beta-lactam, aminoglycoside, and quinolone antibiotics.
Nucleotide sequences of 16 transmissible plasmids identified in nine multidrug-resistant Escherichia coli isolates expressing an ESBL phenotype isolated from food-producing animals and healthy humans.
Nucleotide sequences of 16 transmissible plasmids identified in nine multidrug-resistant Escherichia coli isolates expressing an ESBL phenotype isolated from food-producing animals and healthy humans.
Nucleotide sequences of 16 transmissible plasmids identified in nine multidrug-resistant Escherichia coli isolates expressing an ESBL phenotype isolated from food-producing animals and healthy humans.
Nucleotide sequences of 16 transmissible plasmids identified in nine multidrug-resistant Escherichia coli isolates expressing an ESBL phenotype isolated from food-producing animals and healthy humans.
Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future.
The paper discusses the evolution of antimicrobial resistance in Neisseria gonorrhoeae, focusing on various resistance mechanisms including beta-lactamase production, target modification, efflux pumps, and ribosomal mutations. Key resistance genes and mutations identified include blaTEM-1, tetM, folP, penA, mtrR, rpsJ, gyrA, parC, 23S_rRNA, and ermB.
Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system.
The study identifies blaKPC-2 and blaKPC-3 as the primary carbapenem resistance genes in KPC-producing Enterobacter isolates, along with various ESBL genes such as blaSHV-5, blaSHV-12, blaSHV-154, blaCTX-M-15, and blaTEM-1. Additionally, plasmid-mediated fluoroquinolone resistance genes qnrA and qnrB were detected.
Fluorescent TEM-1 beta-lactamase with wild-type activity as a rapid drug sensor for in vitro drug screening.
The study describes the development of a fluorescent TEM-1 beta-lactamase sensor with wild-type activity for in vitro drug screening, utilizing a Val216Cys mutation and fluorophore labeling to detect drug binding.
Rapid Detection of Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae from Urine Samples by Use of the ESBL NDP Test
The study describes the rapid detection of extended-spectrum-beta-lactamase (ESBL)-producing Enterobacteriaceae from urine samples using the ESBL NDP test. It identifies various ESBL genes, including blaCTX-M-1, blaCTX-M-15, blaCTX-M-3, blaTEM-1, blaSHV-1, and blaTEM-24, which confer resistance to cefotaxime, ceftazidime, and cefepime.
Rapid Detection of Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae from Urine Samples by Use of the ESBL NDP Test
The study describes the rapid detection of extended-spectrum-beta-lactamase (ESBL)-producing Enterobacteriaceae from urine samples using the ESBL NDP test. It identifies various ESBL genes, including blaCTX-M-1, blaCTX-M-15, blaCTX-M-3, blaTEM-1, blaSHV-1, and blaTEM-24, which confer resistance to cefotaxime, ceftazidime, and cefepime.
Emergence of bla TEM Type Extended-Spectrum β -Lactamase Producing Salmonella spp. in the Urban Area of Bangladesh.
The study identifies the emergence of bla TEM gene-mediated extended-spectrum beta-lactamase (ESBL) production among Salmonella spp. in Bangladesh, highlighting the increasing prevalence of multidrug-resistant (MDR) Salmonella strains.
Antibiotic Multiresistance Analysis of Mesophilic and Psychrotrophic Pseudomonas spp. Isolated from Goat and Lamb Slaughterhouse Surfaces throughout the Meat Production Process.
The study identified multiple antibiotic resistance genes in Pseudomonas spp. isolated from slaughterhouse surfaces, including beta-lactamases (bla CTX, bla TEM), sulfonamide resistance (sulII), trimethoprim resistance (dfrD), tetracycline resistance (tetQ), erythromycin resistance (ereA), and chloramphenicol resistance (catA2).
Prevalence and impact of extended-spectrum β-lactamase production on clinical outcomes in cancer patients with Enterobacter species bacteremia.
The study found that 15.3% of Enterobacter spp. blood isolates from cancer patients produced extended-spectrum β-lactamases (ESBLs), primarily CTX-M, SHV-12, and TEM types. While ESBL-positive isolates were associated with more frequent inappropriate empirical antimicrobial therapy, they did not lead to worse clinical outcomes.
Identification of aminoglycoside and β-lactam resistance genes from within an infant gut functional metagenomic library.
The study identified various aminoglycoside and β-lactam resistance genes in the infant gut microbiome, highlighting the presence of a diverse resistance reservoir even in the absence of antibiotic selective pressure.
Co-existence of beta-lactamases in clinical isolates of Escherichia coli from Kathmandu, Nepal.
The study reports the high prevalence of bla CTX-M-type ESBL and co-existence of ESBLs and carbapenemases in E. coli isolates from Kathmandu, Nepal. It identifies multiple beta-lactamase genes including bla CTX-M, bla SHV, bla TEM, bla VIM, bla IMP, and bla NDM-1.
ESBL-producing Salmonella enterica serovar Typhi in traveler returning from Guatemala to Spain.
The study reports an ESBL-producing Salmonella enterica serovar Typhi strain carrying bla TEM-1, bla CTX-M-15, and acc(6')-Ib, highlighting the emergence of multidrug-resistant S. Typhi in the Americas.
Identification of TEM-135 beta-lactamase in Neisseria gonorrhoeae strains carrying African and Toronto plasmids in Argentina.
The study identifies the presence of the blaTEM-135 gene in Neisseria gonorrhoeae isolates in Argentina, which confers resistance to penicillin. Additionally, a new variant, blaTEM-220, was discovered.
Identification of TEM-135 β-lactamase in Neisseria gonorrhoeae strains carrying African and Toronto plasmids in Argentina.
Identification of TEM-135 β-lactamase in Neisseria gonorrhoeae strains carrying African and Toronto plasmids in Argentina.
Identification of TEM-135 β-lactamase in Neisseria gonorrhoeae strains carrying African and Toronto plasmids in Argentina.
Identification of TEM-135 β-lactamase in Neisseria gonorrhoeae strains carrying African and Toronto plasmids in Argentina.
Genomic Analysis of Antimicrobial Resistance in Clinical Isolates of Escherichia coli
The study identified various AMR genes in ExPEC E. coli strains, including beta-lactamases (blaCTX-M, blaSHV, blaTEM), quinolone resistance genes (qnrS1), aminoglycoside modifying enzymes (aac(6')-Ib, aadA), tetracycline resistance genes (tet(A)), macrolide resistance genes (mph(A), erm(B), mef(A)), and others. These genes were associated with resistance to multiple antibiotics.
Plasmid-mediated resistance to cephalosporins and fluoroquinolones in various Escherichia coli sequence types isolated from rooks wintering in Europe.
The study identified several plasmid-mediated resistance genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-24, bla TEM-52, bla CTX-M-14, bla CTX-M-55, bla SHV-12, bla CTX-M-8, bla CTX-M-25, bla CTX-M-28, bla CMY-2, qnrS1, qnrB19, and aac(6′)-Ib-cr, in Escherichia coli isolates from rooks in Europe.
Trends in serotype distribution and antimicrobial susceptibility in Salmonella enterica isolates from humans in Belgium, 2009 to 2013.
The study identifies plasmid-mediated quinolone resistance (PMQR) alleles qnrS1, qnrD1, and qnrB, as well as beta-lactamase genes blaSHV-12, blaTEM-52, blaCTX-M-14, and blaCTX-M-15 in Salmonella enterica isolates from Belgium. It also reports chromosomal mutations in gyrA and parC contributing to fluoroquinolone resistance.
Genomic signature of multidrug-resistant Salmonella enterica serovar typhi isolates related to a massive outbreak in Zambia between 2010 and 2012.
The study identifies multiple antimicrobial resistance genes in multidrug-resistant Salmonella enterica serovar Typhi isolates from Zambia, including strA, strB, blaTEM-1, sul1, sul2, dfrA7, and catA1. Mutations in the gyrA gene were also associated with fluoroquinolone resistance.
First Description of KPC-2-Producing Klebsiella oxytoca Isolated from a Pediatric Patient with Nosocomial Pneumonia in Venezuela.
The study describes the first nosocomial KPC-2-producing Klebsiella oxytoca isolate in Venezuela, which was resistant to carbapenems, cephalosporins, and aminoglycosides but susceptible to ciprofloxacin, colistin, and tigecycline. The isolate carried a 21-kb conjugative plasmid with blaKPC-2, blaCTX-M-8, and blaTEM-15 genes.
beta-lactamases produced by amoxicillin-clavulanate-resistant enterobacteria isolated in Buenos Aires, Argentina: a new blaTEM gene.
The study identified a new blaTEM variant, blaTEM-163, which confers resistance to amoxicillin-clavulanic acid. It also characterized blaTEM-1b and blaTEM-1a as prevalent alleles among amoxicillin-clavulanic acid-resistant enterobacteria.
beta-lactamases produced by amoxicillin-clavulanate-resistant enterobacteria isolated in Buenos Aires, Argentina: a new blaTEM gene.
The study identified a new blaTEM variant, blaTEM-163, which confers resistance to amoxicillin-clavulanic acid. It also characterized blaTEM-1b and blaTEM-1a as prevalent alleles among amoxicillin-clavulanic acid-resistant enterobacteria.
beta-lactamases produced by amoxicillin-clavulanate-resistant enterobacteria isolated in Buenos Aires, Argentina: a new blaTEM gene.
The study identified a new blaTEM variant, blaTEM-163, which confers resistance to amoxicillin-clavulanic acid. It also characterized blaTEM-1b and blaTEM-1a as prevalent alleles among amoxicillin-clavulanic acid-resistant enterobacteria.
beta-lactamases produced by amoxicillin-clavulanate-resistant enterobacteria isolated in Buenos Aires, Argentina: a new blaTEM gene.
The study identified a new blaTEM variant, blaTEM-163, which confers resistance to amoxicillin-clavulanic acid. It also characterized blaTEM-1b and blaTEM-1a as prevalent alleles among amoxicillin-clavulanic acid-resistant enterobacteria.
β-lactamases produced by amoxicillin-clavulanate-resistant enterobacteria isolated in Buenos Aires, Argentina: a new blaTEM gene.
β-lactamases produced by amoxicillin-clavulanate-resistant enterobacteria isolated in Buenos Aires, Argentina: a new blaTEM gene.
β-lactamases produced by amoxicillin-clavulanate-resistant enterobacteria isolated in Buenos Aires, Argentina: a new blaTEM gene.
β-lactamases produced by amoxicillin-clavulanate-resistant enterobacteria isolated in Buenos Aires, Argentina: a new blaTEM gene.
Drug resistance profiles and clonality of sporadic Shigella sonnei isolates in Ankara, Turkey
The study identified blaSHV-12, blaTEM-1, and blaCTX-M-15 genes in ESBL-producing Shigella sonnei isolates, highlighting the presence of multidrug-resistant strains in Ankara, Turkey.
Diversity, distribution and quantification of antibiotic resistance genes in goat and lamb slaughterhouse surfaces and meat products.
The study identified various tetracycline, sulfonamide, and beta-lactam resistance genes in goat and lamb slaughterhouse surfaces and meat products, highlighting the prevalence of tet genes and their potential role in the spread of antibiotic resistance.
Multiresistant bacteria isolated from chicken meat in Austria.
The study identified ESBL-producing E. coli with bla SHV-12, bla CTX-m-1, and bla SHV-2 genes, VRE with van A and van B genes, and MRCNS with the mec A gene in chicken meat samples from Austria.
Characterization of the plasmid genes blaT-4 and blaT-5 which encode the broad-spectrum beta-lactamases TEM-4 and TEM-5 in enterobacteriaceae.
Dissemination of cephalosporin resistance genes between Escherichia coli strains from farm animals and humans by specific plasmid lineages.
The study identified and characterized various cephalosporin resistance genes, including blaCTX-M-1, blaTEM-52, and blaCMY-2, in Escherichia coli strains from humans, poultry, and pigs, highlighting the role of specific plasmid lineages in the dissemination of these resistance genes.
Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin.
The study identified various AMR genes, including bla TEM, dfr, strB, tet(A), and tet(B), in Gram-negative fecal bacteria from volunteers treated with amoxicillin, minocycline, or placebo. The prevalence of these genes increased significantly in the amoxicillin-treated group.
Multiplicity of TEM-derived beta-lactamases from Klebsiella pneumoniae strains isolated at the same hospital and relationships between the responsible plasmids.
Multiplicity of TEM-derived beta-lactamases from Klebsiella pneumoniae strains isolated at the same hospital and relationships between the responsible plasmids.
Multiplicity of TEM-derived beta-lactamases from Klebsiella pneumoniae strains isolated at the same hospital and relationships between the responsible plasmids.
Multiplicity of TEM-derived beta-lactamases from Klebsiella pneumoniae strains isolated at the same hospital and relationships between the responsible plasmids.
Multiplicity of TEM-derived beta-lactamases from Klebsiella pneumoniae strains isolated at the same hospital and relationships between the responsible plasmids.
Multiplicity of TEM-derived beta-lactamases from Klebsiella pneumoniae strains isolated at the same hospital and relationships between the responsible plasmids.
Fluoroquinolone-resistant and extended-spectrum β-lactamase-producing Escherichia coli from the milk of cows with clinical mastitis in Southern Taiwan.
The study identified several extended-spectrum beta-lactamase (ESBL) genes including bla TEM, bla CMY, bla CTX, bla SHV, and bla DHA in Escherichia coli isolates from cows with clinical mastitis. Additionally, mutations in gyrA and parC were associated with fluoroquinolone resistance.
Prevalence of virulence determinants and antimicrobial resistance among commensal Escherichia coli derived from dairy and beef cattle.
The study identified several antimicrobial resistance genes in commensal E. coli from dairy and beef cattle, including blaTEM, blaSHV, aadA1, tetA, tetB, and tetC. These genes conferred resistance to ampicillin, streptomycin, and tetracycline. Dairy cattle isolates showed higher resistance rates compared to beef cattle.
Phenotypic and Molecular Characterization of Extended-Spectrum β-Lactamase Produced by Escherichia coli, and Klebsiella pneumoniae Isolates in an Educational Hospital.
The study identified the presence of blaTEM and blaSHV genes in E. coli and K. pneumoniae isolates, which confer resistance to various beta-lactam antibiotics, highlighting the prevalence of extended-spectrum beta-lactamases in these pathogens.
Molecular characterization and epidemiology of cefoxitin resistance among Enterobacteriaceae lacking inducible chromosomal ampC genes from hospitalized and non-hospitalized patients in Algeria: description of new sequence type in Klebsiella pneumoniae isolates.
The study identified blaCMY-4 and blaDHA-1 as the primary plasmid-mediated AmpC beta-lactamase genes responsible for cefoxitin resistance in Enterobacteriaceae isolates in Algeria. Additionally, blaTEM-1, qnrB4, and aac(6')-Ib were found to coexist with these genes, contributing to multidrug resistance.
Increase in resistance to extended-spectrum cephalosporins in Salmonella isolated from retail chicken products in Japan.
The study identified the presence of plasmid-mediated extended-spectrum cephalosporin resistance genes, including bla CMY-2, bla CTX-M-2, bla CTX-M-15, bla TEM-20, bla TEM-52, and bla SHV-12, in Salmonella isolates from chicken products in Japan. These genes were associated with resistance to various cephalosporins and other beta-lactam antibiotics.
Multidrug resistance and extended-spectrum beta-lactamases genes among Escherichia coli from patients with urinary tract infections in Northwestern Libya.
The study identified bla TEM, bla OXA, and bla CTX-M genes in E. coli isolates from patients with urinary tract infections in Libya, contributing to multidrug resistance and extended-spectrum beta-lactamase production.
Computer aided screening of potent inhibitor compounds against inhibitor resistant TEM β-lactamase mutants from traditional Chinese medicine.
The study identified several inhibitor-resistant TEM β-lactamase mutants (R244S, S130G, M69I) and evaluated their resistance to β-lactamase inhibitors. Salvianolic acid E was found to effectively reduce the MIC of cefoperazone-sulbactam against the R244S mutant.
Antibiotic-resistant Klebsiella pneumoniae and Escherichia coli high-risk clones and an IncFII(k) mosaic plasmid hosting Tn1 (blaTEM-4) in isolates from 1990 to 2004.
A high-resolution genomic analysis of multidrug-resistant hospital outbreaks of Klebsiella pneumoniae.
The study identified two multidrug-resistant Klebsiella pneumoniae lineages responsible for hospital outbreaks, characterized by the presence of bla NDM-1, qnrB1, and other resistance genes, along with fluoroquinolone resistance mutations in gyrA and parC.
A triple mutant in the Ω-loop of TEM-1 beta-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis.
The W165Y/E166Y/P167G triple mutant of TEM-1 beta-lactamase exhibits increased ceftazidime resistance through conformational changes and an altered catalytic mechanism.
Resistance phenotypes and genotypes among multiple-antimicrobial-resistant Salmonella enterica subspecies enterica serovar Choleraesuis strains isolated between 2008 and 2012 from slaughter pigs in Okinawa Prefecture, Japan.
The study identified multiple antimicrobial resistance genes in Salmonella enterica subspecies enterica serovar Choleraesuis strains, including blaTEM, strA, strB, aadA1, aadA2, aphA1, aacC2, tetB, sul1, sul2, dhfrXII, and dhfrXIII. Additionally, mutations in the QRDRs of gyrA and parC were associated with quinolone resistance.
Antimicrobial resistance of Escherichia coli isolates from canine urinary tract infections.
The study identified bla TEM-1, tet(B), tet(A), cmlA, floR, and aacC2 as key antimicrobial resistance genes in E. coli isolates from canine urinary tract infections, along with mutations in gyrA and parC conferring fluoroquinolone resistance.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases.
The study characterizes the activity of ceftazidime, ceftaroline, and aztreonam in combination with avibactam against isogenic E. coli strains expressing various beta-lactamase genes, demonstrating that avibactam effectively restores the activity of these β-lactams against strains producing class A, C, and D beta-lactamases.
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases.
The study characterizes the activity of ceftazidime, ceftaroline, and aztreonam in combination with avibactam against isogenic E. coli strains expressing various beta-lactamase genes, demonstrating that avibactam effectively restores the activity of these β-lactams against strains producing class A, C, and D beta-lactamases.
TEM and SHV Genes in Klebsiella pneumoniae Isolated from Cockroaches and Their Antimicrobial Resistance Pattern.
The study identified the presence of TEM and SHV genes in K. pneumoniae isolated from cockroaches, which conferred resistance to several beta-lactam antibiotics. Imipenem showed 100% sensitivity against the isolates.
Longitudinal study of extended-spectrum-β-lactamase- and AmpC-producing Enterobacteriaceae in household dogs.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla SHV-12, and bla CMY-2, in ESBL-producing Enterobacteriaceae isolated from household dogs. These genes were found to confer resistance to various beta-lactam antibiotics.
Longitudinal study of extended-spectrum-β-lactamase- and AmpC-producing Enterobacteriaceae in household dogs.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla SHV-12, and bla CMY-2, in ESBL-producing Enterobacteriaceae isolated from household dogs. These genes were found to confer resistance to various beta-lactam antibiotics.
Longitudinal study of extended-spectrum-β-lactamase- and AmpC-producing Enterobacteriaceae in household dogs.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla SHV-12, and bla CMY-2, in ESBL-producing Enterobacteriaceae isolated from household dogs. These genes were found to confer resistance to various beta-lactam antibiotics.
Longitudinal study of extended-spectrum-β-lactamase- and AmpC-producing Enterobacteriaceae in household dogs.
Ceftriaxone-resistant Salmonella enterica serotype typhimurium sequence type 313 from Kenyan patients is associated with the blaCTX-M-15 gene on a novel IncHI2 plasmid.
The study identifies the blaCTX-M-15 gene on a novel IncHI2 plasmid pKST313 as a key factor in ceftriaxone resistance in Salmonella enterica serotype Typhimurium ST313 isolates from Kenya.
Frequency of PER, VEB, SHV, TEM and CTX-M Genes in Resistant Strains of Pseudomonas aeruginosa Producing Extended Spectrum beta-lactamases.
The study identified blaTEM-116, blaVEB-1, and blaPER-1 as the most prevalent ESBL genes in Pseudomonas aeruginosa isolates from Zahedan, Iran, with blaTEM being 100% prevalent.
Improved detection of extended spectrum beta-lactamase (ESBL)-producing Escherichia coli in input and output samples of German biogas plants by a selective pre-enrichment procedure.
The study identified bla CTX-M, bla TEM, and bla SHV genes in ESBL-producing E. coli isolates from input and output samples of German biogas plants, highlighting the persistence of these resistance genes despite the biogas process.
Clinical epidemiology and molecular analysis of extended-spectrum-β-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types 131 and 648.
The study identified bla CTX-M-15, aac (3)-IIa, aadA1, aadA2, aadA5, qnrB4, qnrS1, aac (6')-Ib-cr, bla OXA-1, bla TEM-1B, bla SHV-12, bla CMY-42, bla DHA-1, mphA, ermB, catA1, catB3, sul1, sul2, dfrA12, dfrA17, dfrA1, dfrA5, tetA, tetB, and tetD as key AMR genes in ESBL-producing E. coli isolates in Nepal, highlighting the prevalence of multidrug resistance.
Role of pleiotropy during adaptation of TEM-1 beta-lactamase to two novel antibiotics.
Simple multiplex PCR assays to detect common pathogens and associated genes encoding for acquired extended spectrum betalactamases (ESBL) or carbapenemases from surgical site specimens in Vietnam.
The study identified several AMR genes including SHV, CTX-M, TEM, NDM-1, PER-1, Oxa23, and Oxa58 in surgical site infection specimens in Vietnam.
Clinical and microbiological profiles of shigellosis in children.
The study identified bla CTX-M-15, bla CTX-M-14, and bla TEM-1 genes in ceftriaxone-resistant Shigella flexneri strains, highlighting the emergence of extended-spectrum beta-lactamases (ESBLs) in Shigella.
Bacteriophages Isolated from Chicken Meat and the Horizontal Transfer of Antimicrobial Resistance Genes.
The study identified several antimicrobial resistance genes, including tet(A), aphA1, blaTEM, and floR, which were transduced by phages isolated from chicken meat, highlighting the role of bacteriophages in the horizontal transfer of antimicrobial resistance.
The prevalence of Escherichia coli strains with extended spectrum beta-lactamases isolated in China.
The study identified blaCTX-M and blaTEM genes as the primary mechanisms of extended-spectrum beta-lactamase (ESBL) production in Escherichia coli isolates from Shandong Province, China. The most prevalent ESBL types were CTX-M-14 and CTX-M-15, along with TEM-1 and TEM-135.
Bacterial swarms recruit cargo bacteria to pave the way in toxic environments.
P. vortex can transport antibiotic-resistant cargo bacteria, such as E. coli expressing beta-lactamase, to detoxify beta-lactam antibiotics and enable co-dispersal.
Molecular characteristics of extended-spectrum cephalosporin-resistant Enterobacteriaceae from humans in the community.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and others, as well as plasmidic AmpC genes like bla CMY-2 and bla DHA-1, in various Enterobacteriaceae isolates from healthy humans in the community.
Molecular characteristics of extended-spectrum cephalosporin-resistant Enterobacteriaceae from humans in the community.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and others, as well as plasmidic AmpC genes like bla CMY-2 and bla DHA-1, in various Enterobacteriaceae isolates from healthy humans in the community.
Molecular characteristics of extended-spectrum cephalosporin-resistant Enterobacteriaceae from humans in the community.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and others, as well as plasmidic AmpC genes like bla CMY-2 and bla DHA-1, in various Enterobacteriaceae isolates from healthy humans in the community.
Outbreak of uncommon O4 non-agglutinating Salmonella typhimurium linked to minced pork, Saxony-Anhalt, Germany, January to April 2013.
The study identified the resistance genes blaTEM, strA-B, sul2, and tet(B) associated with the ASSuT phenotype in monophasic Salmonella Typhimurium DT193 strains. Additionally, 54% of the isolates showed resistance to chloramphenicol, although no specific chloramphenicol resistance genes were detected.
Carriage of extended-spectrum β-lactamases in pig farmers is associated with occurrence in pigs.
The study identified blaCTX-M-1, blaTEM-52, and blaCTX-M-14 as the most common extended-spectrum beta-lactamase (ESBL) genes in both pigs and humans, indicating clonal transmission between pigs and pig farmers.
Occurrence of SHV, TEM and CTX-M beta-lactamase Genes Among Enteropathogenic Escherichia coli Strains Isolated From Children With Diarrhea.
The study identified the presence of bla CTX-M1, bla CTX-M15, bla SHV, and bla TEM genes in EPEC isolates, highlighting the prevalence of ESBLs and their role in antibiotic resistance.
Characterization of Multidrug Resistant Extended-Spectrum Beta-Lactamase-Producing Escherichia coli among Uropathogens of Pediatrics in North of Iran.
The study identified TEM, SHV, CTX, and VEB beta-lactamase genes as the primary drivers of extended-spectrum beta-lactamase production in E. coli isolates from pediatric patients in northern Iran, with TEM being the most prevalent. These genes conferred resistance to various beta-lactam antibiotics.
Occurrence of Multidrug Resistant Extended Spectrum Beta-Lactamase-Producing Bacteria on Iceberg Lettuce Retailed for Human Consumption.
The study identified ESBL-producing bacteria on iceberg lettuce, including K. pneumoniae isolates carrying SHV-type and TEM-type beta-lactamase genes, as well as S. marcescens with a CTX-M-1 beta-lactamase. These genes confer resistance to cefotaxime.
Point-of-care multiplex PCR promises short turnaround times for microbial testing in hospital-acquired pneumonia--an observational pilot study in critical ill patients.
The study evaluated the performance of a point-of-care multiplex PCR system for detecting pathogens and antibiotic resistance markers in hospital-acquired pneumonia. The system showed significantly shorter turnaround times compared to conventional microbiological diagnostics, although its performance was limited by frequent test failures and non-concordant results.
Outbreak of Ciprofloxacin-Resistant Shigella sonnei Associated with Travel to Vietnam, Republic of Korea.
The study reports an outbreak of ciprofloxacin-resistant Shigella sonnei linked to travel to Vietnam, with the identification of blaCTX-M-15 and blaTEM-1 beta-lactamase genes and QRDR mutations in gyrA and parC contributing to resistance.
Profiling of antimicrobial resistance and plasmid replicon types in beta-lactamase producing Escherichia coli isolated from Korean beef cattle.
The study identified the TEM-1-type beta-lactamase gene as the primary cause of β-lactam resistance in E. coli isolates from Korean beef cattle, with no detection of ESBL or AmpC beta-lactamases.
First description of plasmid-mediated quinolone resistance determinants and β-lactamase encoding genes in non-typhoidal Salmonella isolated from humans, one companion animal and food in Romania.
The study identified plasmid-mediated quinolone resistance (PMQR) genes such as qnrA, qnrB, qnrS, aac(6')-Ib-cr, and qepA, along with beta-lactamase-encoding genes like blaTEM, blaPSE-1, blaSHV, and blaCTX-M in non-typhoidal Salmonella isolates from humans, a companion animal, and food in Romania.
Detection of antibiotic resistance, virulence gene determinants and biofilm formation in Aeromonas species isolated from cattle.
The study identified the presence of blaTEM and blaP1 beta-lactamase genes in Aeromonas isolates from cattle faeces, indicating resistance to beta-lactam antibiotics.
Haemophilus ducreyi Cutaneous Ulcer Strains Are Nearly Identical to Class I Genital Ulcer Strains.
The study found that Haemophilus ducreyi cutaneous ulcer (CU) strains are nearly identical to class I genital ulcer (GU) strains and are highly susceptible to antibiotics, including azithromycin. Resistance mechanisms in GU strains included beta-lactamase (blaTEM-1B) and tetracycline resistance genes (tet(B), tet(32), tet(M)).
Sequence analysis of genes mediating extended-spectrum beta-lactamase (ESBL) production in isolates of Enterobacteriaceae in a Lagos Teaching Hospital, Nigeria.
The study identified bla CTX-M-15 as the predominant ESBL gene in Enterobacteriaceae isolates, with high prevalence among E. coli and K. pneumoniae. Additionally, bla TEM-1, bla SHV-11, bla SHV-12, and bla SHV-112 were also detected.
Comparative analysis of antimicrobial resistance in enterotoxigenic Escherichia coli isolates from two paediatric cohort studies in Lima, Peru.
The study identified several AMR genes in ETEC isolates from Peruvian children, including bla TEM-like for ampicillin resistance, sul2 for sulfamethoxazole resistance, tet(A) and tet(B) for tetracycline resistance, and mph(A) for azithromycin resistance.
Mapping the Evolution of Hypervirulent Klebsiella pneumoniae.
The study identifies antibiotic resistance genes in hypervirulent Klebsiella pneumoniae isolates, highlighting the presence of SHV beta-lactamase and additional resistance genes in one isolate, CAS813, which exhibits resistance to multiple antibiotics.
Diagnosis of bacteremia in pediatric oncologic patients by in-house real-time PCR.
The study identified several AMR genes including blaCTX, blaTEM, blaSPM, mecA, and vanA in pediatric oncologic patients with bloodstream infections, demonstrating the utility of real-time PCR for rapid detection of pathogens and resistance genes.
Isolated cell behavior drives the evolution of antibiotic resistance.
The study characterizes the beta-lactamase genes blaTEM-20, blaTEM-15, and blaA42G, demonstrating their role in conferring resistance to cefotaxime through enzymatic inactivation.
Isolated cell behavior drives the evolution of antibiotic resistance.
The study characterizes the beta-lactamase genes blaTEM-20, blaTEM-15, and blaA42G, demonstrating their role in conferring resistance to cefotaxime through enzymatic inactivation.
Emergence of concurrent infections with colistin-resistant ESBL-positive Klebsiella pneumoniae and OXA-23-producing Acinetobacter baumannii sensitive to colistin only in a Romanian cardiac intensive care unit.
The study identifies colistin-resistant ESBL-positive Klebsiella pneumoniae harboring bla CTX-M-15, bla SHV-11, bla OXA-1, bla TEM-1b, and aac(6')-Ib-cr, as well as OXA-23-producing Acinetobacter baumannii sensitive to colistin.
MALDI-TOF MS as a Tool To Detect a Nosocomial Outbreak of Extended-Spectrum-β-Lactamase- and ArmA Methyltransferase-Producing Enterobacter cloacae Clinical Isolates in Algeria.
The study identified several AMR genes, including bla CTX-M, bla TEM, armA, aadA2, aac(6')-Ib-cr, and ant(2")-Ia, in Enterobacter cloacae isolates from Algeria and France, highlighting the prevalence of multidrug resistance in these isolates.
Molecular characterization of selected multidrug resistant Pseudomonas from water distribution systems in southwestern Nigeria.
The study identified multiple antibiotic resistance genes in multidrug-resistant Pseudomonas isolates from water distribution systems in southwestern Nigeria, including tet(A), sul1, blaTEM, aph(3")c, and ant(3")b.
In Vivo Evolution of Bacterial Resistance in Two Cases of Enterobacter aerogenes Infections during Treatment with Imipenem.
The study identifies mutations in omp35, omp36, cpxA, rob, phoQ, and pmrB that contribute to carbapenem resistance in Enterobacter aerogenes during imipenem treatment.
Draft Genome Sequence of a Pathogenic O86:H25 Sequence Type 57 Escherichia coli Strain Isolated from Poultry and Carrying 12 Acquired Antibiotic Resistance Genes.
The study reports the draft genome sequence of an E. coli strain carrying 12 acquired antibiotic resistance genes, including beta-lactamases, aminoglycoside modifying enzymes, sulfonamide resistance, trimethoprim resistance, tetracycline resistance, and streptothricin resistance.
Emergence of Antibiotic Resistance-Associated Clones Among Escherichia coli Recovered From Newborns With Early-Onset Sepsis and Meningitis in the United States, 2008-2009.
The study identified a high rate of ampicillin resistance and the presence of the extended-spectrum beta-lactamase CTX-M-15 in a multidrug-resistant E. coli strain ST131 H30-Rx, highlighting the emergence of antibiotic resistance-associated clones in E. coli causing early-onset sepsis and meningitis in newborns.
Phenotypic and Molecular Characterisation of Extended-Spectrum Beta-Lactamase Producing Escherichia coli Obtained from Animal Fecal Samples in Ado Ekiti, Nigeria.
The study identified blaTEM and blaCTX-M genes in ESBL-producing E. coli isolates from animal fecal samples, highlighting the presence of multidrug-resistant strains and the importance of monitoring antibiotic resistance in livestock.
Dissemination of Extended-Spectrum beta-lactamases and Quinolone Resistance Genes Among Clinical Isolates of Uropathogenic Escherichia coli in Children.
The study identified the prevalence of extended-spectrum beta-lactamase (ESBL) genes (bla-CTX-M, bla-SHV, bla-TEM) and quinolone resistance genes (qnrB, qnrS) in uropathogenic E. coli isolates from children with urinary tract infections. bla-CTX-M was the most prevalent ESBL gene, while qnrB and qnrS were the most commonly detected quinolone resistance genes.
Environmental Isolate of Rahnella aquatilis Harbors Class 1 Integron.
The study reports the first description of a class 1 integron in an environmental isolate of Rahnella aquatilis, harboring the dfrA1-aadA1 gene cassette array and the blaTEM gene, contributing to resistance against trimethoprim, streptomycin, spectinomycin, ampicillin, and piperacillin.
Performance Evaluation of the Verigene Gram-Positive and Gram-Negative Blood Culture Test for Direct Identification of Bacteria and Their Resistance Determinants from Positive Blood Cultures in Hong Kong.
The Verigene Blood Culture Test effectively identifies bacteria and their resistance determinants, including bla CTX-M, bla OXA, vanA, and mecA genes, demonstrating high sensitivity and specificity for detecting antimicrobial resistance in clinical settings.
Multiple antibiotic resistances among Shiga toxin producing Escherichia coli O157 in feces of dairy cattle farms in Eastern Cape of South Africa.
The study identified multiple antibiotic resistance genes in Shiga toxin-producing Escherichia coli O157 isolates from dairy cattle farms in South Africa, including blaampC, blacmy, blactxm, blatem, tetA, and strA.
Ultrastructural Changes in Clinical and Microbiota Isolates of Klebsiella pneumoniae Carriers of Genes bla SHV, bla TEM, bla CTX-M, or bla KPC When Subject to β-Lactam Antibiotics.
The study identified the presence of bla TEM, bla SHV, bla CTX-M, and bla KPC genes in K. pneumoniae isolates, which confer resistance to various β-lactam antibiotics. The isolates exhibited ultrastructural changes when exposed to sub-MICs of these antibiotics.
The molecular characterisation of Escherichia coli K1 isolated from neonatal nasogastric feeding tubes.
The study identified the blaTEM gene in E. coli K1 strains, which confers resistance to ampicillin. The gene was found in ST95, ST394, and ST2076 isolates.
Prevalence and characteristics of extended-spectrum beta-lactamase genes in Escherichia coli isolated from piglets with post-weaning diarrhea in Heilongjiang province, China.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-14, bla CTX-M-55, bla CTX-M-65, and bla TEM-52, along with plasmid-mediated quinolone resistance (PMQR) genes such as oqxAB, qnrS, qnrB, qepA, and aac(6')-Ib-cr in Escherichia coli isolates from piglets with post-weaning diarrhea in Heilongjiang province, China.
Molecular Characteristics of Class A beta-lactamases
The paper characterizes various class A beta-lactamases, including TEM-1, GIL-1, OXY, CTX-M, SFO-1, CARBA, GES, PER-1, and VEB-1, highlighting their roles in conferring resistance to β-lactam antibiotics such as penicillins, cephalosporins, and carbapenems.
Characterization of genetic structures of the QepA3 gene in clinical isolates of Enterobacteriaceae.
The study characterizes the genetic structures of the qepA3 gene in Enterobacteriaceae isolates, identifying associated resistance genes such as blaCTX-M-14, blaTEM-12, and rmtB, which contribute to multidrug resistance.
Detection of ESBL- and AmpC-producing E. coli isolates from urinary tract infections.
The study identified blaTEM and blaCMY-2 genes as responsible for ESBL and AmpC production in E. coli isolates from urinary tract infections, highlighting their role in resistance to cephalosporins and cephamycins.
CTX-M-1 and CTX-M-15-producing Escherichia coli in dog faeces from public gardens.
The study identified CTX-M-1 and CTX-M-15-producing Escherichia coli in dog faeces from public gardens in Copenhagen, Denmark. These isolates showed resistance to cefotaxime and other antibiotics.
Resistance of Undisturbed Soil Microbiomes to Ceftriaxone Indicates Extended Spectrum β-Lactamase Activity.
The study identifies the presence of extended spectrum beta-lactamase (ESBL) genes, including bla TEM, bla CTX-M, and bla OXA, in soil microbiomes, suggesting that these genes contribute to the resistance of soil microbiomes to ceftriaxone.
Molecular detection of antimicrobial resistance in local isolates of Staphylococcus epidermidis from urinary tract infections in Faisalabad region of Pakistan.
The study identified multiple antimicrobial resistance genes in Staphylococcus epidermidis isolates from urinary tract infections in Pakistan, including tetM, tetK, aac(6')/aph(2"), aacA-aphD, ermA, blaZ, mecA, MeccA, and blaTEM-1, indicating widespread multidrug resistance.
Plasmid-mediated beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli resistant to ceftazidime.
Plasmid-mediated beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli resistant to ceftazidime.
TEM mediated extended spectrum cephalosporin resistance in clinical & environmental isolates of Gram negative bacilli: A report from northeast India.
The study identified TEM-mediated extended-spectrum cephalosporin resistance in clinical and environmental isolates of Gram-negative bacilli, highlighting the spread of resistance genes in water bodies and hospitals.
Evolution of AbGRI2-0, the Progenitor of the AbGRI2 Resistance Island in Global Clone 2 of Acinetobacter baumannii.
The study identifies several AMR genes in the A320 strain of Acinetobacter baumannii, including blaTEM, aacC1, aadA1, sul1, catA1, and aphA1b, which confer resistance to various antibiotics.
β-Lactamase Characterization of Gram-Negative Pathogens Recovered from Patients Enrolled in the Phase 2 Trials for Ceftazidime-Avibactam: Clinical Efficacies Analyzed against Subsets of Molecularly Characterized Isolates.
The study characterized β-lactamase genes in baseline pathogens from patients enrolled in phase 2 trials for ceftazidime-avibactam, identifying CTX-M-14, CTX-M-15, OXA-1, TEM-1, OXA-1/30, SHV-12, ACC-4, CMY-42, NDM-1, VIM-2, PER-1, and OXA-23 as key resistance determinants against ceftazidime.
Prevalence of bla TEM-220 gene in Penicillinase-producing Neisseria gonorrhoeae strains carrying Toronto/Rio plasmid in Argentina, 2002 - 2011.
The study identified the bla TEM-220 gene in PPNG isolates carrying Toronto/Rio plasmid in Argentina, which confers resistance to penicillin and ampicillin. Additionally, the T539C substitution in the bla TEM gene was found in a majority of isolates.
Escherichia coli Population Structure and Antibiotic Resistance at a Buffalo/Cattle Interface in Southern Africa.
The study identified tetracycline, trimethoprim, and amoxicillin resistance genes (tet, dfrA, and blaTEM-1) in E. coli strains from buffalo and cattle populations in Zimbabwe, highlighting the role of human-animal interfaces in the dissemination of antibiotic resistance.
beta-lactamases Encoded by blaCTX-M Group I Genes as Determinants of Resistance of Esbl-Positive Enterobacteriaceae in European Soldiers in Tropical Mali.
The study identifies blaTEM-1 and blaCTX-M group I as significant contributors to β-lactam resistance in ESBL-positive Enterobacteriaceae isolated from European soldiers in Mali.
Antimicrobial susceptibility and pathogenic genes of Staphylococcus aureus isolated from the oral cavity of patients with periodontitis.
The study identified the blaZ, aph(3')-IIIa, and tem genes as responsible for penicillin, gentamicin, and ampicillin resistance in Staphylococcus aureus isolates from periodontitis patients.
Identification and antimicrobial resistance prevalence of pathogenic Escherichia coli strains from treated wastewater effluents in Eastern Cape, South Africa.
The study identified several AMR genes in E. coli isolates from wastewater effluents, including strA, aadA, catI, cmlA1, blaTEM, and various tetracycline resistance genes (tetA, tetB, tetC, tetD, tetK, tetM). These genes conferred resistance to multiple antibiotics such as streptomycin, gentamicin, chloramphenicol, ampicillin, and tetracycline.
Identification of Extended-Spectrum β-Lactamases Escherichia coli Strains Isolated from Market Garden Products and Irrigation Water in Benin.
The study identified bla TEM, bla SHV, and bla CTX-M genes in E. coli strains isolated from market garden products and irrigation water in Benin, indicating resistance to amoxicillin.
Production of extended-spectrum beta-lactamases and the potential indirect pathogenic role of Prevotella isolates from the cystic fibrosis respiratory microbiota.
Prevotella isolates from cystic fibrosis patients produce extended-spectrum beta-lactamases (ESBLs), particularly bla TEM-116, which confer resistance to β-lactam antibiotics such as ceftazidime and cefotaxime. Some isolates also exhibited passive resistance by protecting Pseudomonas aeruginosa from ceftazidime.
The Complete Sequence and Comparative Analysis of a Multidrug-Resistance and Virulence Multireplicon IncFII Plasmid pEC302/04 from an Extraintestinal Pathogenic Escherichia coli EC302/04 Indicate Extensive Diversity of IncFII Plasmids.
The study characterizes the multidrug-resistant plasmid pEC302/04 from an extraintestinal pathogenic E. coli strain, identifying several AMR genes including blaTEM-1, aadA1, aadB, cmlA, and sul1, which confer resistance to various antibiotics.
Novel plasmid-mediated beta-lactamase (TEM-10) conferring selective resistance to ceftazidime and aztreonam in clinical isolates of Klebsiella pneumoniae.
Novel plasmid-mediated beta-lactamase (TEM-10) conferring selective resistance to ceftazidime and aztreonam in clinical isolates of Klebsiella pneumoniae.
Novel plasmid-mediated beta-lactamase (TEM-10) conferring selective resistance to ceftazidime and aztreonam in clinical isolates of Klebsiella pneumoniae.
Draft Genome Sequence of Proteus mirabilis NO-051/03, Representative of a Multidrug-Resistant Clone Spreading in Europe and Expressing the CMY-16 AmpC-Type beta-lactamase.
The draft genome sequence of Proteus mirabilis NO-051/03 reveals the presence of multiple acquired resistance genes, including blaCMY-16 and blaTEM-1b, which confer resistance to β-lactams, as well as genes for resistance to aminoglycosides, chloramphenicol, tetracyclines, trimethoprim, and sulfonamides. Additionally, mutations in gyrA, gyrB, and parC contribute to fluoroquinolone resistance.
TEM-4, a new plasmid-mediated beta-lactamase that hydrolyzes broad-spectrum cephalosporins in a clinical isolate of Escherichia coli.
The study identifies TEM-4, a new plasmid-mediated beta-lactamase that hydrolyzes broad-spectrum cephalosporins and aztreonam in a clinical isolate of Escherichia coli.
TEM-4, a new plasmid-mediated beta-lactamase that hydrolyzes broad-spectrum cephalosporins in a clinical isolate of Escherichia coli.
TEM-4, a new plasmid-mediated beta-lactamase that hydrolyzes broad-spectrum cephalosporins in a clinical isolate of Escherichia coli.
TEM-4, a new plasmid-mediated beta-lactamase that hydrolyzes broad-spectrum cephalosporins in a clinical isolate of Escherichia coli.
Microarray Evaluation of Antimicrobial Resistance and Virulence of Escherichia coli Isolates from Portuguese Poultry.
The study identified several antimicrobial resistance genes in Escherichia coli isolates from Portuguese poultry, including tet(A), blaTEM, sul1, and blaCTX-M. High levels of resistance to tetracycline, ampicillin, and cefotaxime were observed.
Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine beta-lactamases by Relieving Steric Strain.
The study demonstrates that replacing the active-site serine with glycine in various serine beta-lactamases enhances their thermal stability by reducing steric strain, although this substitution significantly reduces catalytic efficiency.
IncF Plasmids Are Commonly Carried by Antibiotic Resistant Escherichia coli Isolated from Drinking Water Sources in Northern Tanzania.
The study identified several antibiotic resistance genes, including bla TEM-1, bla CTX-M, tet(A), and tet(B), carried by IncF plasmids in multidrug-resistant E. coli isolates from Tanzanian water sources. These genes contribute to resistance against ampicillin, ceftazidime, and tetracycline.
Characterization of Antibiotic Resistance Profiles of Ocular Enterobacteriaceae Isolates.
The study identified ESBL genes (blaCTX-M, blaOXA, blaSHV, blaTEM), QNR genes (qnrA, qnrB, qnrS), and gyra mutations (Ser83Leu) in ocular Enterobacteriaceae isolates, highlighting the prevalence of multidrug resistance.
Genetic characterization of TEM-type ESBL-associated antibacterial resistance in Enterobacteriaceae in a tertiary hospital in Ghana.
The study identified the TEM-type ESBL gene as a significant contributor to beta-lactam resistance in Enterobacteriaceae isolates from a Ghanaian hospital, with 19.6% of ESBL-positive isolates carrying the blaTEM gene.
Phenotypic and Molecular Assessment of Drug Resistance Profile and Genetic Diversity of Waterborne Escherichia coli.
The study identified ESBL genes (blaTEM, blaCTX-M3, blaOXA, and blaSHV) in 38% of E. coli isolates from the Nowohucki Reservoir, indicating the presence of multidrug-resistant strains. These genes confer resistance to beta-lactam antibiotics such as ampicillin and ticarcillin.
Antibiotic Resistance, Core-Genome and Protein Expression in IncHI1 Plasmids in Salmonella Typhimurium.
The study identified multiple antibiotic resistance genes in IncHI1 plasmids of Salmonella Typhimurium, including tet(B), tet(A), blaTEM, strA, strB, sul2, aadA, dfrA, catA1, aphA1a, and aad(3)IId, which confer resistance to various antibiotics such as tetracycline, beta-lactam, streptomycin, sulfonamide, aminoglycoside, chloramphenicol, and trimethoprim.
Detection of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Market-Ready Chickens in Zambia.
The study detected ESBL-producing E. coli in poultry in Zambia, identifying blaCTX-M, blaSHV, and blaTEM genes as responsible for beta-lactam resistance.
Impact on Bacterial Resistance of Therapeutically Nonequivalent Generics: The Case of Piperacillin-Tazobactam.
The study characterizes the TEM-1 beta-lactamase gene in E. coli strains and shows that a generic piperacillin-tazobactam product can enrich resistant subpopulations compared to the innovator.
Neonatal infections with multidrug-resistant ESBL-producing E. cloacae and K. pneumoniae in Neonatal Units of two different Hospitals in Antananarivo, Madagascar.
The study identified bla CTX-M-15 and bla TEM-1 genes as the primary mechanisms of beta-lactam resistance in ESBL-producing E. cloacae and K. pneumoniae isolates from neonatal units in Madagascar.
Veterinary Hospital Dissemination of CTX-M-15 Extended-Spectrum Beta-Lactamase-Producing Escherichia coli ST410 in the United Kingdom.
The study identified bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla TEM-1, bla OXA-1, bla CMY-2, and aac(6')-Ib - cr as the primary AMR genes in ESC-resistant E. coli isolates from UK companion animals. These genes were associated with resistance to multiple antibiotics including beta-lactams and quinolones.
Evidence of household transfer of ESBL-/pAmpC-producing Enterobacteriaceae between humans and dogs - a pilot study.
The study identified bla CTX-M-27, bla CMY-2, and bla TEM-1 as the resistance genes responsible for extended-spectrum cephalosporin resistance in Enterobacteriaceae isolated from humans and dogs in the same households.
Fecal Colonization with Extended-Spectrum Beta-Lactamase and AmpC-Producing Escherichia coli.
The study identified ES β L and AmpC-producing E. coli isolates in fecal samples, with bla CTX-M-15 being the most prevalent gene. The isolates showed resistance to various β -lactam antibiotics.
Molecular characterization and analysis of high-level multidrug-resistance of Shigella flexneri serotype 4s strains from China.
The study identified multiple AMR genes, including blaTEM-1, blaOXA-1, blaCTX-M-14, blaCTX-M-79, qnrS, and aac(6')-Ib-cr, contributing to multidrug resistance in Shigella flexneri serotype 4s strains.
Prevalence and Diversity of Salmonella Serotypes in Ecuadorian Broilers at Slaughter Age.
The study identified the presence of bla CTX-M, bla TEM, bla SHV, and bla CMY genes in cefotaxime-resistant Salmonella isolates, as well as the mcr-1 gene in colistin-resistant isolates. S. Infantis showed high resistance rates to multiple antibiotics, including sulfamethoxazole, nalidixic acid, and ciprofloxacin.
Streaming algorithms for identification of pathogens and antibiotic resistance potential from real-time MinION(TM) sequencing.
The study presents a real-time analysis framework for MinION sequencing data, demonstrating the ability to identify pathogens and antibiotic resistance genes within a few hours of sequencing. Key resistance genes identified include blaSHV, mphA, strA, strB, blaTEM, sul2, blaOXA, aac3, aac6, blaCMY, blaCFE, blaLAT, blaBIL, QnrB, aadA, oqxA, tetA, oqxB, rmtC, sul1, sul3, fosA, blaNDM, oqxA, blaSHV, oqxB, aadB, sul1, sul3, blaOXA, blaOKP, fosA, blaSHV, blaOKP, blaLEN, oqxA, and oqxB.
Surveillance of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Dairy Cattle Farms in the Nile Delta, Egypt.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M1/15, bla CTX-M9, bla TEM, and bla SHV, as well as carbapenemase genes bla OXA-48 and bla OXA-181, in ESBL-producing Escherichia coli isolates from dairy cattle farms in the Nile Delta, Egypt.
Occurrence of OXA-48 Carbapenemase and Other β-Lactamase Genes in ESBL-Producing Multidrug Resistant Escherichia coli from Dogs and Cats in the United States, 2009-2013.
The study identified the presence of various β-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-123, bla CTX-M-9, bla CTX-M-14, bla TEM-1, bla SHV-12, bla CMY-2, and bla OXA-48, in ESBL-producing multidrug resistant E. coli isolates from dogs and cats in the United States. Additionally, the PMQR gene aac(6')-Ib-cr was found to be prevalent in these isolates.
Risk factors and spatial distribution of extended spectrum β-lactamase-producing- Escherichia coli at retail poultry meat markets in Malaysia: a cross-sectional study.
The study identified the presence of extended spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) in retail poultry meat markets in Malaysia, highlighting the prevalence of genes such as bla TEM, bla SHV, bla CTX-M, and bla OXA, which confer resistance to beta-lactam antibiotics.
Clinical and Molecular Characteristics of Neonatal Extended-Spectrum β-Lactamase-Producing Gram-Negative Bacteremia: A 12-Year Case-Control-Control Study of a Referral Center in Taiwan.
The study identified SHV-type, CTX-M, and TEM-type extended-spectrum beta-lactamase (ESBL) genes in neonatal Gram-negative bacteremia. These ESBLs conferred resistance to cephalosporins, and the isolates were multidrug resistant.
Detection of Extended Spectrum Beta-Lactamases Resistance Genes among Bacteria Isolated from Selected Drinking Water Distribution Channels in Southwestern Nigeria.
The study detected the presence of extended spectrum beta-lactamase (ESBL) resistance genes, including bla TEM, bla SHV, and bla CTX, in bacteria isolated from drinking water distribution channels in Southwestern Nigeria. These genes were found to confer resistance to beta-lactam antibiotics such as ampicillin, amoxicillin/clavulanic acid, and ceftiofur.
First report of TEM-104-, SHV-99-, SHV-108-, and SHV-110-producing Klebsiella pneumoniae from Iran.
This study reports the first identification of TEM-104, SHV-99, SHV-108, and SHV-110-producing Klebsiella pneumoniae in Iran, highlighting the prevalence of these extended-spectrum beta-lactamase genes among clinical isolates.
First report of TEM-104-, SHV-99-, SHV-108-, and SHV-110-producing Klebsiella pneumoniae from Iran.
This study reports the first identification of TEM-104, SHV-99, SHV-108, and SHV-110-producing Klebsiella pneumoniae in Iran, highlighting the prevalence of these extended-spectrum beta-lactamase genes among clinical isolates.
Characterization of Two Multidrug-Resistant IncA/C Plasmids from the 1960s by Using the MinION Sequencer Device.
The study characterizes two multidrug-resistant IncA/C plasmids, R16a and IP40a, from the 1960s, identifying resistance genes blaTEM-1D, aphA1b, and sul2, which confer resistance to ampicillin, kanamycin, and sulfonamides, respectively.
Identification and Characterization of Cefotaxime Resistant Bacteria in Beef Cattle.
The study identified the presence of extended-spectrum beta-lactamase (ESBL) genes, particularly bla TEM and bla CTX-M, in cefotaxime-resistant bacteria isolated from beef cattle. These genes were found to confer resistance to cefotaxime and other beta-lactam antibiotics.
Increased prevalence of antibiotic-resistant E. coli in gulls sampled in Southcentral Alaska is associated with urban environments.
The study found that antibiotic-resistant E. coli isolates from gulls in urban areas of Southcentral Alaska had higher resistance rates compared to those from remote areas, with specific beta-lactamase genes like bla CTX-M-15, bla TEM-1, and bla CMY-2 being identified.
Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa.
The study identified multiple S. Typhi genotypes in Nigeria, with a focus on antimicrobial resistance genes and plasmids. Key resistance genes included blaTEM-1, catA1, tetB, dfrA15, sul1, sul2, strAB, aad, and qnrS, primarily associated with the IncHI1 plasmid. Quinolone resistance was linked to gyrA mutations S83Y and S83F.
Establishment of a Simple and Quick Method for Detecting Extended-Spectrum beta-lactamase (ESBL) Genes in Bacteria.
The study established a multiplex-PCR system for rapid and accurate detection of four common ESBL genes (blaTEM, blaCTX-M-1, blaCTX-M-9, and blaSHV) in clinical bacterial isolates.
Occurence of ArmA and RmtB Aminoglycoside Resistance 16S rRNA Methylases in Extended-Spectrum β-Lactamases Producing Escherichia coli in Algerian Hospitals.
Occurence of ArmA and RmtB Aminoglycoside Resistance 16S rRNA Methylases in Extended-Spectrum β-Lactamases Producing Escherichia coli in Algerian Hospitals.
Occurence of ArmA and RmtB Aminoglycoside Resistance 16S rRNA Methylases in Extended-Spectrum β-Lactamases Producing Escherichia coli in Algerian Hospitals.
Modelling proteins' hidden conformations to predict antibiotic resistance.
The study identifies the TEM-1 beta-lactamase and its mutations E104K and G238S as critical for increased resistance to cefotaxime, highlighting the importance of conformational states in antibiotic resistance mechanisms.
Engineering Specificity from Broad to Narrow: Design of a beta-lactamase Inhibitory Protein (BLIP) Variant That Exclusively Binds and Detects KPC beta-lactamase.
The study engineered a BLIP variant (K74T:W112D) that specifically binds and detects KPC-2 beta-lactamase with high affinity while showing reduced affinity for other class A beta-lactamases like TEM-1.
Novel non-β-lactam inhibitor of beta-lactamase TEM-171 based on acylated phenoxyaniline.
The study identifies PA-34, a novel non-β-lactam inhibitor of beta-lactamase TEM-171, demonstrating reversible competitive inhibition with a K_i of 88 μM.
Extended-Spectrum-Beta-Lactamase- and Plasmid-Encoded Cephamycinase-Producing Enterobacteria in the Broiler Hatchery as a Potential Mode of Pseudo-Vertical Transmission.
The study identified several beta-lactamase genes, including TEM-1, TEM-52, CTX-M1, CTX-M15, CMY-2, SHV-1, and SHV-2, which confer resistance to various beta-lactam antibiotics in ESBL-/pAmpC-producing enterobacteria isolated from broiler parent flocks and hatchery environments.
Extended-Spectrum-Beta-Lactamase- and Plasmid-Encoded Cephamycinase-Producing Enterobacteria in the Broiler Hatchery as a Potential Mode of Pseudo-Vertical Transmission.
The study identified several beta-lactamase genes, including TEM-1, TEM-52, CTX-M1, CTX-M15, CMY-2, SHV-1, and SHV-2, which confer resistance to various beta-lactam antibiotics in ESBL-/pAmpC-producing enterobacteria isolated from broiler parent flocks and hatchery environments.
High Prevalence of β-lactamase and Plasmid-Mediated Quinolone Resistance Genes in Extended-Spectrum Cephalosporin-Resistant Escherichia coli from Dogs in Shaanxi, China.
The study identified a high prevalence of β-lactamase and plasmid-mediated quinolone resistance genes in extended-spectrum cephalosporin-resistant Escherichia coli from dogs in Shaanxi, China. Key genes included bla CTX-M-15, bla TEM-1, bla SHV-12, and aac(6')-Ib-cr, along with other β-lactamase and PMQR genes.
High Prevalence of β-lactamase and Plasmid-Mediated Quinolone Resistance Genes in Extended-Spectrum Cephalosporin-Resistant Escherichia coli from Dogs in Shaanxi, China.
The study identified a high prevalence of β-lactamase and plasmid-mediated quinolone resistance genes in extended-spectrum cephalosporin-resistant Escherichia coli from dogs in Shaanxi, China. Key genes included bla CTX-M-15, bla TEM-1, bla SHV-12, and aac(6')-Ib-cr, along with other β-lactamase and PMQR genes.
Isolation, Antimicrobial Susceptibility Profile and Detection of Sul1, blaTEM, and blaSHV in Amoxicillin-Clavulanate-Resistant Bacteria Isolated From Retail Sausages in Kampar, Malaysia.
The study identified blaTEM, blaSHV, and Sul1 as the primary resistance mechanisms in amoxicillin-clavulanate-resistant bacteria isolated from retail sausages in Malaysia.
ESBL-Producing Escherichia coli from Cows Suffering Mastitis in China Contain Clinical Class 1 Integrons with CTX-M Linked to ISCR1.
The study identified a high prevalence of ESBL-producing E. coli from mastitic cows in China, with blaCTX-M-15 being the most common ESBL gene. These isolates were found to carry clinical class 1 integrons and ISCR1 elements, contributing to multidrug resistance.
Comparison of Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolates from Drinking Well Water and Pit Latrine Wastewater in a Rural Area of China.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-55, bla CTX-M-64, and bla TEM-1, in ESBL-producing Escherichia coli isolates from drinking well water and pit latrine wastewater in a rural area of China.
Characterisation of Commensal Escherichia coli Isolated from Apparently Healthy Cattle and Their Attendants in Tanzania.
The study identified several antimicrobial resistance genes in commensal E. coli isolates from cattle and their attendants in Tanzania, including blaTEM-1B, sul1, sul2, and tet(A). These genes conferred resistance to beta-lactams, sulfamethoxazole-trimethoprim, and tetracycline, respectively.
Antimicrobial Resistant Enteropathogenic Escherichia coli and Salmonella spp. in Houseflies Infesting Fish in Food Markets in Zambia.
The study identified ESBL-producing E. coli carrying blaCTX-M, blaSHV, and blaTEM genes in houseflies infesting fish in Zambian food markets, indicating a significant threat to public health.
The occurrence of ESBL-producing Escherichia coli carrying aminoglycoside resistance genes in urinary tract infections in Saudi Arabia.
The study identified ESBL-producing E. coli isolates carrying bla CTX-M1, bla CTX-M15, bla OXA1, and bla TEM genes, along with aminoglycoside resistance genes such as aac6, aac6Ib, aadA4, and strB.
Genetic markers associated with resistance to beta-lactam and quinolone antimicrobials in non-typhoidal Salmonella isolates from humans and animals in central Ethiopia.
The study identified blaTEM, blaTEM-1, blaTEM-57, blaOXA-10, and blaCTX-M-15 as the primary beta-lactam resistance genes in Salmonella isolates. Mutations in gyrA (Ser83-Phe, Asp87-Gly) and parC (Thr57-Ser, Ser80-Ile, Tyr83-Phe) were the main mechanisms of quinolone resistance.
Genetic markers associated with resistance to beta-lactam and quinolone antimicrobials in non-typhoidal Salmonella isolates from humans and animals in central Ethiopia.
The study identified blaTEM, blaTEM-1, blaTEM-57, blaOXA-10, and blaCTX-M-15 as the primary beta-lactam resistance genes in Salmonella isolates. Mutations in gyrA (Ser83-Phe, Asp87-Gly) and parC (Thr57-Ser, Ser80-Ile, Tyr83-Phe) were the main mechanisms of quinolone resistance.
Genetic markers associated with resistance to beta-lactam and quinolone antimicrobials in non-typhoidal Salmonella isolates from humans and animals in central Ethiopia.
The study identified blaTEM, blaTEM-1, blaTEM-57, blaOXA-10, and blaCTX-M-15 as the primary beta-lactam resistance genes in Salmonella isolates. Mutations in gyrA (Ser83-Phe, Asp87-Gly) and parC (Thr57-Ser, Ser80-Ile, Tyr83-Phe) were the main mechanisms of quinolone resistance.
Cyclic Boronates Inhibit All Classes of β-Lactamases.
Cyclic boronates inhibit all classes of β-lactamases, including class A ESBLs like CTX-M-15, class C AmpC, and class D OXA enzymes, showing potent inhibition against various β-lactamases.
Panel strain of Klebsiella pneumoniae for beta-lactam antibiotic evaluation: their phenotypic and genotypic characterization.
The study characterizes various AMR genes and mutations in K. pneumoniae panel strains, including beta-lactamases (bla SHV-11, bla TEM-1, bla CTX-M15, bla OXA-1, bla SHV-12, bla SHV-187, bla SHV-158, bla DHA-1, bla CMY-2), aminoglycoside modifying enzymes (aac(6')-Ib, strA, strB, aadA1, aadA2), quinolone resistance genes (qnrB66, qnrB4, oqxA, oqxB), tetracycline resistance (tet(A)), trimethoprim resistance (dfrA14), sulfonamide resistance (sul1, sul2), and porin genes (OmpK35, OmpK36).
Marine Bivalve Mollusks As Possible Indicators of Multidrug-Resistant Escherichia coli and Other Species of the Enterobacteriaceae Family.
The study identified multiple AMR genes in E. coli isolates from marine bivalves, including bla TEM-1, bla CTX-M-14, bla CTX-M-15, and various aminoglycoside, trimethoprim, sulfonamide, tetracycline, chloramphenicol, quinolone, and macrolide resistance genes. These findings highlight the potential risk of MDR Enterobacteriaceae in marine environments.
A putative multi-replicon plasmid co-harboring beta-lactamase genes blaKPC-2, blaCTX-M-14 and blaTEM-1 and trimethoprim resistance gene dfrA25 from a Klebsiella pneumoniae sequence type (ST) 11 strain in China.
The study identifies a novel multi-replicon plasmid pHS091147 carrying multiple resistance genes, including blaKPC-2, blaCTX-M-14, blaTEM-1, dfrA25, and sul1, which confer resistance to various antibiotics such as carbapenems, cephalosporins, and trimethoprim.
Prevalence of TEM, SHV, and CTX-M Beta-Lactamase genes in the urinary isolates of a tertiary care hospital.
The study identified the prevalence of bla TEM, bla CTX-M, and bla SHV genes among Enterobacteriaceae isolates from urine samples, highlighting the dominance of bla TEM.
Epidemiological, molecular characterization and antibiotic resistance of Salmonella enterica serovars isolated from chicken farms in Egypt.
The study identified various AMR genes in Salmonella enterica serovars isolated from chicken farms in Egypt, including blaTEM, aadA2, floR, cat1, sul1, sul3, tetC, tetA, and intI, which confer resistance to ampicillin, streptomycin, chloramphenicol, sulfamethoxazole, tetracycline, and multiple antibiotics.
Prevalence of MDR pathogens of bacterial meningitis in Egypt and new synergistic antibiotic combinations.
The study identified several AMR genes including TEM, SHV, CTX-M, aac(6')-Ib, and qnrA in MDR isolates from bacterial meningitis patients in Egypt.
Antibiotic-Resistant Extended Spectrum ß-Lactamase- and Plasmid-Mediated AmpC-Producing Enterobacteriaceae Isolated from Retail Food Products and the Pearl River in Guangzhou, China.
The study identified various beta-lactamase genes, including blaSHV-1, blaTEM-1, blaCTX-M-55, blaCTX-M-65, blaDHA-1, blaCMY-2, blaACC-1, and blaCIT, which confer resistance to multiple beta-lactam antibiotics in Enterobacteriaceae isolated from retail food and water samples in Guangzhou, China.
Development of a Rapid Reverse Blot Hybridization Assay for Detection of Clinically Relevant Antibiotic Resistance Genes in Blood Cultures Testing Positive for Gram-Negative Bacteria.
The study developed and evaluated the REBA-EAC assay for the rapid detection of clinically relevant antibiotic resistance genes in blood cultures positive for Gram-negative bacteria. The assay successfully identified various beta-lactamase genes, including ESBLs (CTX-M, TEM, SHV), AmpC beta-lactamases (DHA, CMY-2-like, ACT), and carbapenemases (IMP, VIM, NDM, KPC, OXA-48-like, SPM).
Prevalence and Molecular Characteristics of Extended-Spectrum β-Lactamase Genes in Escherichia coli Isolated from Diarrheic Patients in China.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M, bla TEM, bla OXA, and bla SHV, in Escherichia coli isolates from diarrheic patients in China. These genes were responsible for resistance to third-generation cephalosporins.
Characteristics of extended-spectrum beta-lactamase-producing Escherichia coli isolated from fecal samples of piglets with diarrhea in central and southern Taiwan in 2015.
The study identified bla CTX-M-15 and bla CTX-M-55 as the most common extended-spectrum beta-lactamase genes in Escherichia coli isolated from piglets with diarrhea in southern Taiwan. Additionally, bla TEM-1 and bla TEM-116 were frequently detected.
Characteristics of extended-spectrum beta-lactamase-producing Escherichia coli isolated from fecal samples of piglets with diarrhea in central and southern Taiwan in 2015.
The study identified bla CTX-M-15 and bla CTX-M-55 as the most common extended-spectrum beta-lactamase genes in Escherichia coli isolated from piglets with diarrhea in southern Taiwan. Additionally, bla TEM-1 and bla TEM-116 were frequently detected.
Resistance to antimicrobial drugs in different surface waters and wastewaters of Guadeloupe.
The study identified several AMR genes including blaCTX-M, blaSHV, blaTEM, qnrB19, qnrB1, aac(6')-Ib-cr, VEB-1, CMY-2, and CMY-8 in Enterobacteriaceae isolates from surface waters and wastewaters in Guadeloupe. These genes conferred resistance to various antibiotics such as ceftazidime, cefotaxime, ampicillin, ciprofloxacin, gentamicin, and cefoxitin.
Risk factors for ESBL-producing Escherichia coli on pig farms: A longitudinal study in the context of reduced use of antimicrobials.
The study identified several ESBL genes, including bla CTX-M-1, bla TEM-52, bla CTX-M-14, bla CTX-M-15, bla CTX-M-2, and bla CTX-M-32, associated with ESBL-producing E. coli on pig farms. The use of cephalosporins was strongly linked to the presence of ESBL- E. coli.
WGS to predict antibiotic MICs for Neisseria gonorrhoeae.
The study identifies various AMR genes and mutations in Neisseria gonorrhoeae that contribute to resistance against multiple antibiotics, including cefixime, penicillin, azithromycin, ciprofloxacin, and tetracycline. These findings are supported by WGS and multivariate linear regression models.
Identification of a novel sequence type of Escherichia coli as the causative agent of pyelonephritis and bloodstream infection.
The study identifies a novel sequence type of Escherichia coli (ST-458) responsible for pyelonephritis and bloodstream infection, carrying multiple antibiotic resistance genes and mutations associated with resistance to fluoroquinolones, aminoglycosides, sulfonamides, and beta-lactams.
Extended-spectrum beta-lactamase-producing Pseudomonas aeruginosa in camel in Egypt: potential human hazard.
The study identified the presence of extended-spectrum beta-lactamase (ESBL)-producing Pseudomonas aeruginosa in camel meat in Egypt, highlighting the potential risk of transmission to humans. The ESBL genes bla PER-1, bla CTX-M, bla SHV, and bla TEM were detected in the isolates.
Genomic Analysis of Factors Associated with Low Prevalence of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli Sequence Type 95 Strains.
The study identifies several AMR genes in ST95 E. coli strains, including blaTEM-1, blaCTX-M14, aadA1, aadA2, aadA5, aac3, strA, strB, tetA, tetB, tetD, sul1, sul2, dfrA5, dfrA12, dfrA17, mphA, and catA1, which confer resistance to various antibiotics such as ampicillin, cephalothin, streptomycin, tetracycline, sulfamethoxazole, trimethoprim, azithromycin, and chloramphenicol.
Day-to-Day Dynamics of Commensal Escherichia coli in Zimbabwean Cows Evidence Temporal Fluctuations within a Host-Specific Population Structure.
The study identified a few antibiotic-resistant E. coli clones in Zimbabwean cows, including resistance to tetracycline, penicillins, and trimethoprim, but these were rare and subdominant.
Prevalence, virulence potential, and pulsed-field gel electrophoresis profiling of Shiga toxin-producing Escherichia coli strains from cattle.
The study identified various antimicrobial resistance genes in STEC isolates from cattle, including ampC, blaTEM, tetE, tetB, and tetC, which confer resistance to beta-lactams and tetracyclines. These findings highlight the importance of monitoring antimicrobial resistance in STEC strains.
Distribution of Integrons and Phylogenetic Groups among Enteropathogenic Escherichia coli Isolates from Children <5 Years of Age in Delhi, India.
The study identified various AMR genes including dfrA1, dfrA7, dfrA12, aadA1, aadA2, sul1, tetA, aacC1, TEM, SHV, CTX-M, OXA, NDM-1, IMP, VIM, ACT, DHA, and CMY in E. coli isolates from children in Delhi, India. These genes were associated with resistance to multiple antibiotics such as trimethoprim, streptomycin, sulfonamides, tetracycline, gentamicin, and various beta-lactams.
Genome Dynamics of Gut-Inhabiting Escherichia coli Strains During Colonization of an Infant
The study identifies the TEM-1b beta-lactamase gene carried on the pNK29 plasmid, which confers resistance to ampicillin and penicillin in Escherichia coli strains. The plasmid was transferred between E. coli lineages in the gut and shows evidence of horizontal gene transfer.
The impact of production of extended-spectrum β-lactamases on the 28-day mortality rate of patients with Proteus mirabilis bacteremia in Korea.
The study identifies bla TEM and bla CTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) production in Proteus mirabilis, which is associated with increased 28-day mortality in patients with bacteremia.
Prevalence and clonal relationship of ESBL-producing Salmonella strains from humans and poultry in northeastern Algeria.
The study identified ESBL-producing Salmonella strains in poultry and human samples, with bla CTX-M-1, bla CTX-M-15, and bla TEM genes being the primary contributors to beta-lactam resistance.
Population Genomic Analysis of 1,777 Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Isolates, Houston, Texas: Unexpected Abundance of Clonal Group 307.
The study identifies the widespread presence of CG307 strains of K. pneumoniae, which exhibit high levels of antimicrobial resistance, particularly through the presence of various beta-lactamase genes such as bla KPC-2, bla NDM-1, bla CTX-M, and bla TEM.
Biofilm Formation Potential of Heat-Resistant Escherichia coli Dairy Isolates and the Complete Genome of Multidrug-Resistant, Heat-Resistant Strain FAM21845.
The study identified multiple antimicrobial resistance genes in the multidrug-resistant, heat-resistant E. coli strain FAM21845, including beta-lactamase blaTEM-1, aminoglycoside resistance genes strA, strB, aadA1, aph(3')-Ic, aph(4)-Ia, aac(3)-IVa, sulfonamide resistance gene sul1, trimethoprim resistance gene dfrA1, tetracycline resistance gene tet(B), disinfectant resistance gene qacEΔ1, and biofilm-related genes mrkABCDF. Additionally, the strain carried genes for resistance to arsenic, silver, and copper.
Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.
The study identified 46 AMR genes or gene families in 90 Klebsiella pneumoniae isolates from Kenya, highlighting the prevalence of multidrug resistance and the diversity of resistance mechanisms.
Detection of emerging antibiotic resistance in bacteria isolated from subclinical mastitis in cattle in West Bengal.
The study identified blaCTX-M, blaTEM, tetA, and tetB genes in Gram-negative bacteria isolated from subclinical mastitis in cattle in West Bengal, indicating the presence of antibiotic resistance mechanisms.
Detection and drug resistance profile of Escherichia coli from subclinical mastitis cows and water supply in dairy farms in Saraburi Province, Thailand.
The study identified several AMR genes in E. coli isolates from subclinical mastitis cows and water supplies, including blaTEM, blaCMY-2, and aac(3)-IIa, which confer resistance to beta-lactams and aminoglycosides.
Genomic and phenotypic characterisation of fluoroquinolone resistance mechanisms in Enterobacteriaceae in Durban, South Africa.
Genomic and phenotypic characterisation of fluoroquinolone resistance mechanisms in Enterobacteriaceae in Durban, South Africa.
Genomic and phenotypic characterisation of fluoroquinolone resistance mechanisms in Enterobacteriaceae in Durban, South Africa.
Genomic and phenotypic characterisation of fluoroquinolone resistance mechanisms in Enterobacteriaceae in Durban, South Africa.
Clonal Diversity of ESBL-Producing Escherichia coli Isolated from Environmental, Human and Food Samples.
The study identifies various ESBL genes, including bla CTX-M-14, bla CTX-M-1, bla SHV-12, and bla TEM-42, in ESBL-producing E. coli isolated from food, environmental, and human samples.
Serotype Distribution, Antimicrobial Resistance, and Class 1 Integrons Profiles of Salmonella from Animals in Slaughterhouses in Shandong Province, China.
The study identified several AMR genes in Salmonella isolates from animals in slaughterhouses in Shandong, China, including blaTEM-1, blaOXA-1, blaCTX-M-55, and aadA2, which confer resistance to various antibiotics such as ampicillin, cefotaxime, and gentamicin.
Association between Virulence Factors and Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae Compared to Nonproducing Isolates.
The study identifies TEM, SHV, and CTX-M-15 beta-lactamase genes as the primary resistance mechanisms in ESBL-producing K. pneumoniae isolates, highlighting their association with reduced susceptibility to multiple beta-lactam antibiotics.
Characterization of the Complete Nucleotide Sequences of IncA/C2 Plasmids Carrying In809-Like Integrons from Enterobacteriaceae Isolates of Wildlife Origin.
The study characterized IncA/C2 plasmids carrying In809-like integrons from Enterobacteriaceae isolates of wildlife origin, identifying several AMR genes including blaIMP-4, blaIMP-26, blaIMP-38, sul2, floR, aac(3)-IId, qnrA1, arr-3, dfrA12, aphA1, aadA16, aadA2, blaOXA-1, blaTEM-1, and blaDHA-1.
Molecular detection of beta-lactamase and integron genes in clinical strains of Klebsiella pneumoniae by multiplex polymerase chain reaction.
The study identified the presence of various beta-lactamase genes (blaTEM, blaCTX-M, blaSHV, blaPER, blaGES, blaVIM, blaIMP, blaOXA, blaKPC) and integron genes (intI, intII, intIII) in clinical strains of Klebsiella pneumoniae, highlighting the prevalence of multidrug resistance.
Systematic longitudinal survey of invasive Escherichia coli in England demonstrates a stable population structure only transiently disturbed by the emergence of ST131.
The study identified various antibiotic resistance genes, including bla CTX-M-15, aac(6')-Ib, bla OXA-1, bla TEM-1, dfrA, mphA, sul1, and tetA, in E. coli isolates, highlighting the multidrug-resistant nature of ST131 and the presence of distinct plasmid profiles contributing to resistance.
Occurrence of the mcr-1 Colistin Resistance Gene and other Clinically Relevant Antibiotic Resistance Genes in Microbial Populations at Different Municipal Wastewater Treatment Plants in Germany.
The study identified the mcr-1 colistin resistance gene and several other clinically relevant antibiotic resistance genes, including ermB, tetM, CTX-M, CTX-M-32, blaTEM, and CMY-2, in wastewater treatment plant samples in Germany.
Induction of beta-lactamase Activity and Decreased β-Lactam Susceptibility by CO(2) in Clinical Bacterial Isolates.
The study identifies the presence of blaTEM and blaSHV beta-lactamase genes in Francisella philomiragia and Haemophilus influenzae, which are induced under 5% CO2 conditions, leading to decreased β-lactam susceptibility.
Klebsiella pneumoniae Isolates from Meningitis: Epidemiology, Virulence and Antibiotic Resistance.
The study identified several beta-lactamase genes (blaSHV-5, blaTEM-1B, blaCMY-2, and blaDHA-1) associated with resistance to cefotaxime and ceftazidime in Klebsiella pneumoniae isolates from meningitis. These genes were predominantly found in post-craniotomy meningitis isolates.
Antimicrobial Resistance and Cytotoxicity of Citrobacter spp. in Maanshan Anhui Province, China.
The study identified the blaTEM-1 gene in two C. freundii isolates, qnrS1 in three Citrobacter isolates, and aac(6')-Ib-cr in three Citrobacter isolates. Additionally, a variant of qnrB77 was found in two C. freundii isolates.
Impact of intrapartum antimicrobial prophylaxis upon the intestinal microbiota and the prevalence of antibiotic resistance genes in vaginally delivered full-term neonates.
Intravenous antimicrobial prophylaxis (IAP) during labor was associated with an increased prevalence of antibiotic resistance genes, particularly beta-lactamase genes such as BLA-tem and CTX-M, in the intestinal microbiota of vaginally delivered full-term neonates.
Horizontal Dissemination of Antimicrobial Resistance Determinants in Multiple Salmonella Serotypes following Isolation from the Commercial Swine Operation Environment after Manure Application.
The study identified various antimicrobial resistance genes, including bla_CMY-2, bla_TEM, aadA2, tet(A), tet(B), sul1, and sul2, in multiple Salmonella serotypes isolated from swine farm environments. These genes were found on plasmids and contributed to resistance against beta-lactams, aminoglycosides, tetracyclines, and sulfonamides.
Comparative Sequence Analysis of Multidrug-Resistant IncA/C Plasmids from Salmonella enterica.
The study identified multiple antimicrobial resistance genes on IncA/C plasmids from various Salmonella serovars, including bla_cmy-2, bla_tem-1, strA, strB, aadB, aph(3')-Ia, tetA, floR, cmlA, sul1, sul2, dfra12, quacE, sugE, merA, merB, merC, merD, and merE, which contribute to multidrug resistance.
Serotyping, antibiotic susceptibility, and virulence genes screening of Escherichia coli isolates obtained from diarrheic buffalo calves in Egyptian farms.
The study identified several antibiotic resistance genes in E. coli isolates from diarrheic buffalo calves in Egypt, including aadB, blaTEM, and Sul1, which confer resistance to aminoglycosides, beta-lactams, and sulfonamides, respectively.
Multiple Antibiotic-Resistant, Extended Spectrum-β-Lactamase (ESBL)-Producing Enterobacteria in Fresh Seafood.
The study identified multiple ESBL genes, including bla CTX, bla SHV, bla TEM, and bla NDM-1, in ESBL-producing enterobacteria isolated from fresh seafood. These genes conferred resistance to various beta-lactam antibiotics, highlighting the presence of multidrug-resistant bacteria in seafood.
Epidemic characterization and molecular genotyping of Shigella flexneri isolated from calves with diarrhea in Northwest China.
The study identified blaTEM-1, blaOXA-1, blaCTX-M-14, and aac(6′)-Ib-cr as key genes contributing to cephalosporin and fluoroquinolone resistance in Shigella flexneri 2a isolates from calves in Northwest China. Mutations in gyrA (S83L, D87N/Y) and parC (S80I) were linked to fluoroquinolone resistance.
Distribution of bla(TEM), bla(SHV), and bla(CTX-M) genes among ESBL-producing P. aeruginosa isolated from Qazvin and Tehran hospitals, Iran.
The study identified blaTEM-1, blaCTX-M-15, blaSHV-1, and blaSHV-12 as the most common ESBL genes in ESBL-producing P. aeruginosa isolates from Iran.
Resistance to Antibiotics, Biocides, Preservatives and Metals in Bacteria Isolated from Seafoods: Co-Selection of Strains Resistant or Tolerant to Different Classes of Compounds.
The study identified multiple antibiotic resistance genes, including sul1, sul2, floR, aadA1, aac(6')-Ib, blaTEM, blaCTX-M, blaPSE, blaNDM-1, qacEΔ1, pcoA/copA, chrB, and pcoR, in bacterial isolates from seafood. These genes conferred resistance to sulfonamides, phenicols, aminoglycosides, beta-lactams, and heavy metals.
Beta-lactamase antimicrobial resistance in Klebsiella and Enterobacter species isolated from healthy and diarrheic dogs in Andhra Pradesh, India.
The study identified several beta-lactamase genes including bla SHV, bla TEM, bla OXA, bla CTX-M Group 1, and bla AmpC in Klebsiella and Enterobacter species isolated from dogs in India, highlighting the prevalence of beta-lactamase-mediated antimicrobial resistance.
The clinical and microbiological characteristics of enteric fever in Cambodia, 2008-2015.
The study identified various AMR genes and mutations in Salmonella Typhi and Salmonella Paratyphi A isolates from Cambodia, including beta-lactamase (blaTEM-1B), chloramphenicol acetyltransferase (catA1), sulfonamide resistance proteins (sul1, sul2), dihydrofolate reductase (dfrA7), tetracycline resistance protein (tet(B)), and streptomycin resistance protein (strAB). Additionally, mutations in the gyrA and gyrB genes were associated with decreased ciprofloxacin susceptibility.
A rapid diagnostic workflow for cefotaxime-resistant Escherichia coli and Klebsiella pneumoniae detection from blood cultures by MALDI-TOF mass spectrometry.
The study developed a rapid diagnostic workflow using MALDI-TOF MS to detect cefotaxime-resistant Escherichia coli and Klebsiella pneumoniae from blood cultures, identifying beta-lactamase genes such as bla CTX-M, bla KPC, bla SHV, and bla TEM as key contributors to resistance.
Rapid Nanopore Sequencing of Plasmids and Resistance Gene Detection in Clinical Isolates.
The study demonstrates the feasibility of rapid nanopore sequencing for detecting plasmid-borne antimicrobial resistance (AMR) genes in clinical isolates. It identifies several AMR genes, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, tetracycline resistance genes, macrolide resistance genes, and phenicol resistance genes, in both Escherichia coli and Klebsiella pneumoniae isolates.
Phenotypic and Molecular Characterization of Multidrug Resistant Klebsiella pneumoniae Isolated from Different Clinical Sources in Al-Najaf Province-Iraq.
The study identified blaSHV, blaTEM, blaCTX-M, qnrB, and aac(6')-Ib-cr genes as the main contributors to multidrug resistance in Klebsiella pneumoniae isolates from burns and urinary tract infections in Iraq.
Molecular screening of antibiotic-resistant determinants among multidrug-resistant clinical isolates of Proteus mirabilis from SouthWest Nigeria.
The study identified several AMR genes, including bla TEM-1, bla CTX-M-15, aac(6')-Ib, aac(6')-Ib-cr, and qnrA, in multidrug-resistant Proteus mirabilis isolates from SouthWest Nigeria.
Characterization of Four Multidrug Resistance Plasmids Captured from the Sediments of an Urban Coastal Wetland.
Four multidrug resistance plasmids were captured from the sediments of an urban coastal wetland. These plasmids carried various resistance genes, including beta-lactamases, tetracycline resistance genes, sulfonamide resistance genes, and others, conferring resistance to multiple antibiotics.
Extensively Drug-Resistant Escherichia coli Sequence Type 1642 Carrying an IncX3 Plasmid Containing the blaKPC-2 Gene Associated with Transposon Tn4401a.
The study identifies several AMR genes in an extensively drug-resistant E. coli ST1642 isolate, including blaKPC-2, blaSHV-11, blaTEM-1, aadA5, strA, strB, aac(3)-IId, mph(A), sul1, sul2, tet(B), dfrA17, and qnrS1, which contribute to resistance against multiple antibiotics.
Occurrence of Salmonella enterica and Escherichia coli in raw chicken and beef meat in northern Egypt and dissemination of their antibiotic resistance markers.
The study identified several AMR genes in Salmonella enterica and Escherichia coli isolates from raw chicken and beef meat in northern Egypt, including bla CTX-M, bla TEM, qnr A, and qnr B, which confer resistance to various antibiotics.
Exploring the Genome and Phenotype of Multi-Drug Resistant Klebsiella pneumoniae of Clinical Origin.
The study identified multiple antimicrobial resistance genes in 11 multidrug-resistant Klebsiella pneumoniae isolates, including ESBL genes (blaCTX-M-15, blaSHV-12, blaTEM-1B), fluoroquinolone resistance genes (oqxAB, qnrB), and others such as catA, catB, tet, sul, dfr, and fosA. These genes contribute to resistance against various antibiotics, highlighting the complex resistance profile of these isolates.
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting.
The study identified various AMR genes and mutations in E. coli isolates from children with cystic fibrosis, cancer, and healthy controls, highlighting differences in resistance profiles between groups.
Molecular characterization of beta-lactamase genes in clinical isolates of carbapenem-resistant Acinetobacter baumannii.
The study identified multiple beta-lactamase genes, including bla OXA-23-like, bla OXA-40-like, bla OXA-51-like, bla TEM, bla SHV, bla ampC, and bla ADC-7, in carbapenem-resistant Acinetobacter baumannii isolates. These genes contribute to resistance against carbapenems and other β-lactam antibiotics.
MinION Nanopore Sequencing Enables Correlation between Resistome Phenotype and Genotype of Coliform Bacteria in Municipal Sewage.
The study identified the beta-lactamase gene blaTEM-171 and the tetracycline resistance gene tet(A) in the multidrug-resistant coliform strain COL1, which were validated through plasmid transformation and antibiotic susceptibility testing.
Risk of Transmission of Antimicrobial Resistant Escherichia coli from Commercial Broiler and Free-Range Retail Chicken in India.
The study identified the presence of multidrug-resistant Escherichia coli in retail chicken meat in India, highlighting the risk of transmission of antimicrobial resistance. Key resistance genes included blaCTX-M-15, blaTEM, and blaSHV, which confer resistance to cephalosporins.
Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand.
The study identified various AMR genes and mutations in Neisseria gonorrhoeae isolates from New Zealand, including bla TEM-1B, mtrR, ponA, penB, gyrA, parC, rpsJ, and 23S rRNA mutations, contributing to resistance against penicillin, ciprofloxacin, tetracycline, and azithromycin.
In vivo selection of a multidrug-resistant Aeromonas salmonicida during medicinal leech therapy.
The study identifies 13 antibiotic resistance genes in a multidrug-resistant Aeromonas salmonicida strain, including the ESBL CTX-M-3, TEM-1, and the unusual β-lactamase SCO-1, along with other resistance mechanisms such as aminoglycoside modification, sulfonamide resistance, tetracycline efflux, and chloramphenicol acetylation.
Phylogeny and antimicrobial resistance in Neisseria gonorrhoeae isolates from Rio de Janeiro, Brazil.
The study characterized 116 Neisseria gonorrhoeae isolates from Rio de Janeiro, Brazil, highlighting high resistance rates to penicillin, tetracycline, ciprofloxacin, and azithromycin. Key resistance mechanisms included chromosomal mutations in ponA, porB, rpsJ, gyrA, parC, and rrl, as well as plasmid-mediated resistance via blaTEM-1 and tetM. Promoter and coding region mutations in mtrR were also linked to azithromycin resistance.
Characterization of multiple antibiotic resistance of culturable microorganisms and metagenomic analysis of total microbial diversity of marine fish sold in retail shops in Mumbai, India.
The study identified multiple antibiotic resistance genes in marine fish isolates, including blaTEM, Class I integron, tetA, aph(3')-IIIa, ermB, aadA, and sul1, indicating a potential risk of antibiotic resistance transmission to humans through the food chain.
Antimicrobial susceptibility and molecular epidemiology of clinical Enterobacter cloacae bloodstream isolates in Shanghai, China.
The study identified several AMR genes in Enterobacter cloacae bloodstream isolates, including ESBLs (SHV-12, CTX-M-15, CTX-M-65), carbapenemases (IMP-26, NDM-1), plasmid-mediated AmpC beta-lactamases (ACT-20, ACT-3, DHA-1), and TEM-1. These genes were associated with resistance to various antibiotics, highlighting the need for continued surveillance.
Whole-genome sequencing reveals transmission of gonococcal antibiotic resistance among men who have sex with men: an observational study.
The study identified the transmission of antibiotic-resistant Neisseria gonorrhoeae strains between men who have sex with men, highlighting the role of specific genes and mutations in conferring resistance to various antibiotics.
Different phenotypic and molecular mechanisms associated with multidrug resistance in Gram-negative clinical isolates from Egypt.
The study identified various AMR genes and mutations contributing to multidrug resistance in Gram-negative clinical isolates from Egypt, highlighting the role of efflux pumps and plasmid-mediated quinolone resistance.
Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models.
The study identifies M182T and M182S as stabilizing mutations in TEM-1 beta-lactamase that enhance resistance to beta-lactam antibiotics by stabilizing the native state and helix 9. M182N and M182V do not confer stabilization.
Porcine commensal Escherichia coli: a reservoir for class 1 integrons associated with IS26.
The study identified 17 antimicrobial resistance genes (ARGs) in 103 class 1 integron-positive Escherichia coli strains from porcine feces, highlighting the prevalence of multidrug-resistant commensal E. coli in pigs and their potential role in the dissemination of resistance genes.
blaOXA-23-like and blaTEM rather than blaOXA-51-like contributed to a high level of carbapenem resistance in Acinetobacter baumannii strains from a teaching hospital in Xi'an, China.
blaOXA-23-like and blaTEM were strongly associated with carbapenem resistance in Acinetobacter baumannii strains, while blaOXA-51-like did not contribute significantly to the resistance phenotype.
High Prevalence of CTX-M-15-Type ESBL-Producing E. coli from Migratory Avian Species in Pakistan.
The study identified a high prevalence of CTX-M-15-type ESBL-producing E. coli in migratory avian species in Pakistan, highlighting the role of wild birds as reservoirs of multidrug-resistant bacteria and the potential for horizontal gene transfer of resistance determinants.
Mutual influence of secondary and key drug-resistance mutations on catalytic properties and thermal stability of TEM-type β-lactamases.
The study characterizes the impact of secondary and key mutations on the catalytic properties and thermal stability of TEM-type β-lactamases, highlighting the role of Q39K, E104K, R164S, and M69V in altering enzyme functionality and stability.
Broad-spectrum resistance of Pseudomonas aeruginosa from shellfish: infrequent acquisition of novel resistance mechanisms.
The study identified the blaTEM-116 gene, sul1 gene, and aadA7 gene cassette in Pseudomonas aeruginosa isolates from shellfish, highlighting the presence of intrinsic and acquired resistance mechanisms in marine environments.
Characterization of an Outbreak of Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae in a Neonatal Intensive Care Unit in Italy.
The study characterizes an outbreak of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit in Italy, identifying the novel bla TEM-206 gene as a contributor to antibiotic resistance.
Characteristics of diarrheagenic Escherichia coli among children under 5 years of age with acute diarrhea: a hospital based study.
The study identified blaNDM-1 and blaKPC-2 as the main carbapenemase genes in carbapenem-resistant DEC strains. blaTEM-1 and blaCTX-M-55 were the major genetic determinants associated with high levels of cephalosporin resistance.
The frequency of Klebsiella pneumonia encoding genes for CTX-M, TEM-1 and SHV-1 extended-spectrum beta lactamases enzymes isolated from urinary tract infection.
The study identified the frequency of ESBL-producing K. pneumonia isolates carrying blaSHV-1, blaTEM-1, blaCTX-M-1, blaCTX-M-2, and blaCTX-M-3 genes, with blaSHV-1 being the most prevalent.
Prevalence and characteristics of extended-spectrum beta-lactamase-producing Escherichia coli in domestic and imported chicken meats in Japan.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M, bla TEM, and bla SHV, in Escherichia coli isolates from domestic and imported chicken meats in Japan. The most prevalent ESBL genes were bla CTX-M-2 and bla CTX-M-1 in domestic isolates, while bla CTX-M-2 and bla CTX-M-8 were predominant in imported isolates. The isolates exhibited multidrug resistance.
Diversity and Antimicrobial Resistance Genotypes in Non-Typhoidal Salmonella Isolates from Poultry Farms in Uganda.
The study identified several antimicrobial resistance genes in non-typhoidal Salmonella isolates from Ugandan poultry farms, including blaTEM-1, cmlA, qnrS, tetA, sul1, dhfrI, and dhfrVII, which confer resistance to various antibiotics such as ampicillin, chloramphenicol, ciprofloxacin, tetracycline, sulfonamide, and trimethoprim.
pSTM6-275, a Conjugative IncHI2 Plasmid of Salmonella enterica That Confers Antibiotic and Heavy-Metal Resistance under Changing Physiological Conditions.
The IncHI2 plasmid pSTM6-275 from Salmonella enterica carries multiple antibiotic and heavy-metal resistance genes, including blaTEM, strA, strB, sul3, aadA1, aadA2, cmlA, aphA2, tetA, mejB, silESRCFBAGP, and pcoGE1ABCDRSE2, which confer resistance to various antibiotics and metals. The plasmid exhibits temperature-dependent resistance to silver and copper, highlighting its adaptability under changing physiological conditions.
Study of pandrug and heavy metal resistance among E. coli from anthropogenically influenced Delhi stretch of river Yamuna.
The study identifies two variants of the blaTEM gene (blaTEM-1 and blaTEM-116) and mer operon genes (merB, merP, and merT) in the pandrug-resistant E. coli isolate MRC11, which contribute to resistance against beta-lactam antibiotics and mercury.
Study of pandrug and heavy metal resistance among E. coli from anthropogenically influenced Delhi stretch of river Yamuna.
The study identifies two variants of the blaTEM gene (blaTEM-1 and blaTEM-116) and mer operon genes (merB, merP, and merT) in the pandrug-resistant E. coli isolate MRC11, which contribute to resistance against beta-lactam antibiotics and mercury.
Prevalence of CTX-M and TEM beta-lactamases in Klebsiella pneumoniae Isolates from Patients with Urinary Tract Infection, Al-Zahra Hospital, Isfahan, Iran.
The study identified blaCTX-M and blaTEM genes as the primary beta-lactamase genes responsible for extended-spectrum beta-lactamase (ESBL) production in K. pneumoniae isolates from urinary tract infections in Iran. Both genes were associated with resistance to cefotaxime and ceftazidime.
Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population.
The study identifies clinically relevant ESBL-producing K. pneumoniae ST307 and E. coli ST38 in an urban West African rat population, highlighting the presence of multidrug-resistant strains carrying various resistance genes such as blaCTX-M-15, blaCTX-M-14, blaCTX-M-9, and others.
Genome Sequencing of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in Cameroon.
The study identified multiple antibiotic resistance genes in ESBL-producing K. pneumoniae isolates from pigs and abattoir workers in Cameroon, including bla CTX-M-15, bla TEM-1B, bla SHV-28, and others, highlighting the presence of multidrug-resistant strains and their potential for zoonotic transmission.
Genome Sequencing of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in Cameroon.
The study identified multiple antibiotic resistance genes in ESBL-producing K. pneumoniae isolates from pigs and abattoir workers in Cameroon, including bla CTX-M-15, bla TEM-1B, bla SHV-28, and others, highlighting the presence of multidrug-resistant strains and their potential for zoonotic transmission.
Genome Sequencing of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in Cameroon.
The study identified multiple antibiotic resistance genes in ESBL-producing K. pneumoniae isolates from pigs and abattoir workers in Cameroon, including bla CTX-M-15, bla TEM-1B, bla SHV-28, and others, highlighting the presence of multidrug-resistant strains and their potential for zoonotic transmission.
A closer look at the antibiotic-resistant bacterial community found in urban wastewater treatment systems.
The study identified various tetracycline resistance genes (Tet B, Tet C, Tet G, Tet M, Tet Q, Tet W, and Tet X) in wastewater treatment plants, highlighting their prevalence and potential dissemination into the environment.
Comprehensive Molecular Characterization of Escherichia coli Isolates from Urine Samples of Hospitalized Patients in Rio de Janeiro, Brazil.
The study identified various AMR genes including blaCTX-M-15, blaCTX-M-8, blaCMY-2, blaKPC-2, blaOXA-1, and blaTEM-1B in E. coli isolates from hospitalized patients in Rio de Janeiro, Brazil. These genes were associated with resistance to multiple antibiotics, highlighting the presence of multidrug-resistant clones.
Comprehensive Evaluation of the MBT STAR-BL Module for Simultaneous Bacterial Identification and beta-lactamase-Mediated Resistance Detection in Gram-Negative Rods from Cultured Isolates and Positive Blood Cultures.
The study evaluated the MBT STAR-BL module for detecting beta-lactamase-mediated resistance in Gram-negative rods from cultured isolates and blood cultures. It identified several beta-lactamase genes, including blaTEM-1b, blaCTX-M-13, blaCTX-M-14, blaNDM-5, blaKPC-2, blaCMY-2, blaOXA-23, blaOXA-51, blaVIM-4, blaPOM-1, and blaL1, which confer resistance to various β-lactam antibiotics.
Impact of human-associated Escherichia coli clonal groups in Antarctic pinnipeds: presence of ST73, ST95, ST141 and ST131.
The study identified the presence of human-associated Escherichia coli clonal groups, including ST131, in Antarctic pinnipeds. It also characterized resistance genes such as blaTEM-1 and tet(A) in some isolates.
Genetic Environment of bla(TEM-1), bla(CTX-M-15), bla(CMY-42) and Characterization of Integrons of Escherichia coli Isolated From an Indian Urban Aquatic Environment.
The study characterizes the genetic environment of bla TEM-1, bla CTX-M-15, and bla CMY-42 in E. coli isolates from an Indian urban aquatic environment, identifying the presence of IS 26, IS Ecp1, and class 1 integrons.
Detection of CTX-M-15 harboring Escherichia coli isolated from wild birds in Tunisia.
The study identifies CTX-M-15-harboring Escherichia coli in wild birds in Tunisia, highlighting the presence of multidrug resistance genes such as bla CTX-M-15, bla TEM-1b, tetA, qnrA1, qnrB1, aac(6')-Ib-cr, aac(3)-II, and sul3.
Recent Increase in the Incidence of TEM-135 beta-lactamase-harboring Neisseria gonorrhoeae in Korea.
The study identifies a continuous increase in the incidence of TEM-135 beta-lactamase-harboring Neisseria gonorrhoeae in Korea, with TEM-135 isolates showing reduced susceptibility to certain antibiotics compared to TEM-1 isolates.
Phenotypic and Genomic Characterization of AmpC-Producing Klebsiella pneumoniae From Korea
Phenotypic and Genomic Characterization of AmpC-Producing Klebsiella pneumoniae From Korea
Dominant serotype distribution and antimicrobial resistance profile of Shigella spp. in Xinjiang, China.
The study identified multiple AMR genes and mutations in Shigella isolates from Xinjiang, China, including bla OXA-1, bla TEM-1, bla CTX-M, qnrB, qnrS, and QRDR mutations in gyrA and parC. These genes and mutations contribute to resistance against cephalosporins, quinolones, and other antibiotics.
Prediction of Phenotypic Antimicrobial Resistance Profiles From Whole Genome Sequences of Non-typhoidal Salmonella enterica.
The study identified various AMR genes and mutations in non-typhoidal Salmonella enterica, including blaTEM-1, strA-strB, sul2, tet(A), qnrS1, aadA2, aadA17, floR, cmlA1, aac(3)-Id, aac(3)-IIa, dfrA12, dfrA1, dfrA14, blaCTX-M-9, blaCTX-M-55, blaSHV-12, blaPSE-1/blaCARB-2, and blaCMY-2, along with mutations in gyrA and parC associated with ciprofloxacin resistance.
Poultry hatcheries as potential reservoirs for antimicrobial-resistant Escherichia coli: A risk to public health and food safety.
The study identified several beta-lactam resistance genes, including bla TEM, bla SHV, bla OXA-1, bla MOX-like, bla CIT-like, and bla FOX, in Escherichia coli isolates from poultry hatcheries, highlighting the potential of hatcheries as reservoirs of antimicrobial-resistant bacteria.
Typhoid Fever due to Extended Spectrum beta-lactamase-Producing Salmonella enterica Serovar Typhi: A Case Report and Literature Review.
The study identifies the presence of blaTEM, blaSHV, and blaCTX-M genes in an ESBL-producing Salmonella enterica serovar Typhi isolate, contributing to resistance against multiple antibiotics including cephalosporins.
Serotype Diversity and Antimicrobial Resistance among Salmonella enterica Isolates from Patients at an Equine Referral Hospital.
The study identified various AMR genes in Salmonella enterica isolates from equine patients, including beta-lactamases, aminoglycoside modifying enzymes, and genes conferring resistance to tetracyclines, macrolides, and other antibiotics.
Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy.
The study identified multiple AMR genes and mutations in Salmonella Typhi and Salmonella Paratyphi A isolates from Nepal, including gyrA and parC mutations associated with fluoroquinolone resistance, and acquired AMR genes such as catA1, dfrA7, sul1, sul2, strA, strB, and blaTEM-1 associated with multidrug resistance.
Genomic Characterization of Nonclonal mcr-1-Positive Multidrug-Resistant Klebsiella pneumoniae from Clinical Samples in Thailand.
The study identifies mcr-1 as the primary mediator of colistin resistance in two nonclonal multidrug-resistant Klebsiella pneumoniae isolates, QS17-0029 and QS17-0161, which also carry multiple other resistance genes including bla NDM-1, bla OXA-232, bla CTX-M-15, and others.
Genomic Characterization of Nonclonal mcr-1-Positive Multidrug-Resistant Klebsiella pneumoniae from Clinical Samples in Thailand.
The study identifies mcr-1 as the primary mediator of colistin resistance in two nonclonal multidrug-resistant Klebsiella pneumoniae isolates, QS17-0029 and QS17-0161, which also carry multiple other resistance genes including bla NDM-1, bla OXA-232, bla CTX-M-15, and others.
Clinically Relevant Plasmid-Host Interactions Indicate that Transcriptional and Not Genomic Modifications Ameliorate Fitness Costs of Klebsiella pneumoniae Carbapenemase-Carrying Plasmids.
The study identified that pKpQIL-UK and pKpQIL-D2 plasmids affect gene expression in K. pneumoniae without causing genomic mutations. These plasmids influence resistance to carbapenems and other antibiotics through the expression of genes like blaKPC and blaTEM, as well as efflux pumps such as acrAB and oqxB.
Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in Escherichia coli.
The study identifies blaTEM-1 gene amplification as a mechanism for piperacillin-tazobactam resistance in E. coli 907355, showing that increased gene dosage leads to higher Bla TEM-1 protein levels and resistance.
Colonization With Levofloxacin-resistant Extended-spectrum β-Lactamase-producing Enterobacteriaceae and Risk of Bacteremia in Hematopoietic Stem Cell Transplant Recipients.
The study identified bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, and bla TEM-1 as genes conferring resistance to various beta-lactam antibiotics in ESBL-producing Enterobacteriaceae isolated from hematopoietic stem cell transplant recipients.
Detection of antimicrobial resistance-associated proteins by titanium dioxide-facilitated intact bacteria mass spectrometry.
The study demonstrates the successful detection of antimicrobial resistance-associated proteins using TiO2-facilitated MALDI-TOF MS without sample pre-treatment. Specific resistance proteins such as blaTEM-1, aacC1, cat, and ampC were identified in various bacterial strains.
Detection of Antibiotic Resistance Determinants and Their Transmissibility among Clinically Isolated Carbapenem-Resistant Escherichia coli from South India.
The study identified TEM, NDM, OXA-181, and CTX-M beta-lactamase genes in carbapenem-resistant E. coli isolates, highlighting their transmissibility and prevalence in South India.
Extended-spectrum β-lactamase & carbapenemase-producing Gram-negative bacilli in neonates from a tertiary care centre in Dibrugarh, Assam, India.
The study identified several β-lactamase genes, including bla SHV, bla TEM, bla CTX-MU, bla OXA23-like, bla OXA51-like, bla OXA58-like, and bla NDM1, in Gram-negative bacteria isolated from neonates with sepsis in Assam, India.
An outbreak of a rare Shiga-toxin-producing Escherichia coli serotype (O117:H7) among men who have sex with men.
The study identified several AMR genes and mutations in STEC O117:H7 isolates, including the azithromycin resistance gene mphA, aadA1, aadA2, aadA5, blaTEM-1B, blaTEM-1C, dfrA1, dfrA12, dfrA14, dfrA, dfrA5, ermB, strA, strB, sul1, sul2, tet(A), tet(B), qnrs1, and a mutation in gyrA (S83L) associated with fluoroquinolone resistance.
An outbreak of a rare Shiga-toxin-producing Escherichia coli serotype (O117:H7) among men who have sex with men.
The study identified several AMR genes and mutations in STEC O117:H7 isolates, including the azithromycin resistance gene mphA, aadA1, aadA2, aadA5, blaTEM-1B, blaTEM-1C, dfrA1, dfrA12, dfrA14, dfrA, dfrA5, ermB, strA, strB, sul1, sul2, tet(A), tet(B), qnrs1, and a mutation in gyrA (S83L) associated with fluoroquinolone resistance.
Antimicrobial resistance and the presence of extended-spectrum beta-lactamase genes in Escherichia coli isolated from the environment of horse riding centers.
The study identified blaTEM and blaCTXM-9 as the primary extended-spectrum beta-lactamase genes in E. coli isolates from horse riding centers, contributing to resistance against multiple antibiotics.
Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine beta-lactamases.
The study characterizes the antibacterial spectrum of a tetrazole-based reversible inhibitor of serine beta-lactamases, showing significant activity against various CTX-M subtypes and other serine beta-lactamases, including CTX-M-9, CTX-M-14, CTX-M-15, CTX-M-27, SHV-2, KPC-2, AmpC, OXA-48, and TEM-1.
The Use of a Combined Bioinformatics Approach to Locate Antibiotic Resistance Genes on Plasmids From Whole Genome Sequences of Salmonella enterica Serovars From Humans in Ghana.
The study identified several AMR genes in Salmonella isolates from Ghana, including blaTEM-1B, blaTEM-52B, blaCTX-M-15, tet(A), dfrA15, sul1, sul2, catA1, strA, strB, aadA1, catB3, qnrB1, aac(6')Ib-cr, and blaOXA-1. These genes were found on various plasmids, highlighting the diversity of resistance mechanisms in the studied isolates.
The Use of a Combined Bioinformatics Approach to Locate Antibiotic Resistance Genes on Plasmids From Whole Genome Sequences of Salmonella enterica Serovars From Humans in Ghana.
The study identified several AMR genes in Salmonella isolates from Ghana, including blaTEM-1B, blaTEM-52B, blaCTX-M-15, tet(A), dfrA15, sul1, sul2, catA1, strA, strB, aadA1, catB3, qnrB1, aac(6')Ib-cr, and blaOXA-1. These genes were found on various plasmids, highlighting the diversity of resistance mechanisms in the studied isolates.
Molecular characterization of fluoroquinolone and/or cephalosporin resistance in Shigella sonnei isolates from yaks.
The study identified fluoroquinolone and cephalosporin resistance mechanisms in Shigella sonnei isolates from yaks, including mutations in gyrA and parC, and the presence of aac(6')-Ib-cr, qnrS, qnrB, blaTEM-1, blaOXA-1, blaCTX-M-14, and blaCTX-M-79 genes.
Characterization of a novel multidrug resistance plasmid pSGB23 isolated from Salmonella enterica subspecies enterica serovar Saintpaul.
The study characterizes a novel multidrug resistance plasmid pSGB23 isolated from Salmonella enterica subspecies enterica serovar Saintpaul, carrying 11 antibiotic resistance genes responsible for resistance to 9 classes of antibiotics and quaternary ammonium compounds.
Association mapping from sequencing reads using k-mers.
The study identified the beta-lactamase TEM-1 (blaTEM-1) gene as strongly associated with ampicillin resistance in E. coli using a k-mer-based association mapping approach.
TEM-184, a Novel TEM-Derived Extended-Spectrum beta-lactamase with Enhanced Activity against Aztreonam.
TEM-184 is a novel TEM-derived extended-spectrum beta-lactamase with enhanced activity against aztreonam, conferring resistance to ceftazidime, aztreonam, and piperacillin.
TEM-184, a Novel TEM-Derived Extended-Spectrum β-Lactamase with Enhanced Activity against Aztreonam.
TEM-184, a Novel TEM-Derived Extended-Spectrum β-Lactamase with Enhanced Activity against Aztreonam.
TEM-184, a Novel TEM-Derived Extended-Spectrum β-Lactamase with Enhanced Activity against Aztreonam.
Prevalence of extended spectrum beta lactamase and plasmid mediated quinolone resistant genes in strains of Klebsiella pneumonia, Morganella morganii, Leclercia adecarboxylata and Citrobacter freundii isolated from poultry in South Western Nigeria.
The study identified the presence of ESBL genes (SHV, TEM, CTX-M) and PMQR genes (qnrA, qnrB, qepA, oqxB) in Klebsiella pneumonia, Morganella morganii, Leclercia adecarboxylata, and Citrobacter freundii isolated from poultry in South Western Nigeria.
A pan-genome-based machine learning approach for predicting antimicrobial resistance activities of the Escherichia coli strains.
The study identifies and characterizes several AMR genes in E. coli, including beta-lactamases (blaTEM-1, blaOXA-1, blaCMY-2, ampC), aminoglycoside modifying enzymes (aac(3')-Ia, aac(3')-VI), dihydrofolate reductases (dfrA1, dfrA5, dfrA12, dfrA15), quinolone resistance proteins (qnrB2, qnrB6, qnrS2), and others. These genes were validated through computational and wet lab methods, showing their roles in conferring resistance to various antibiotics.
Multidrug-resistant Citrobacter freundii ST139 co-producing NDM-1 and CMY-152 from China.
The study identifies a multidrug-resistant Citrobacter freundii strain co-producing NDM-1 and CMY-152, along with other resistance genes such as bla VEB-3, bla TEM-1, qnrS1, and others, highlighting the complex resistance mechanisms in this isolate.
Evolution and Comparative Genomics of F33:A-:B- Plasmids Carrying bla(CTX-M-55) or bla(CTX-M-65) in Escherichia coli and Klebsiella pneumoniae Isolated from Animals, Food Products, and Humans in China.
The study characterizes F33:A−:B− plasmids carrying various AMR genes such as bla(CTX-M-55), bla(CTX-M-65), fosA3, rmtB, and others in E. coli and K. pneumoniae isolates from diverse sources in China.
Spread and Persistence of Virulence and Antibiotic Resistance Genes: A Ride on the F Plasmid Conjugation Module.
The paper reviews the role of F-like plasmids in the spread and persistence of antibiotic resistance and virulence genes, highlighting the importance of these plasmids in the dissemination of resistance genes such as blaTEM-1, sul1, aadA, and catA1, as well as virulence factors like ompP and colicin genes.
Antimicrobial resistance, biofilm synthesis and virulence genes in Salmonella isolated from pigs bred on intensive farms.
The study identified multidrug-resistant Salmonella isolates from pigs, showing resistance to multiple antibiotics including colistin, ciprofloxacin, and others. No ESBL-producing isolates were found, but several virulence genes were detected.
Genomic Characterization of MDR Escherichia coli Harboring bla(OXA-48) on the IncL/M-type Plasmid Isolated from Blood Stream Infection.
The study identified multiple AMR genes, including blaOXA-48, blaCTX-M-3, blaTEM-1B, blaOXA-1, aac(3)-IId, tet(A), tet(R), and blaCMY-70, in an MDR E. coli isolate. It also detected mutations in gyrA (S83L, D87N) and parC (S80I) contributing to fluoroquinolone resistance.
Past and Present Perspectives on beta-lactamases
The paper discusses the evolution and classification of beta-lactamases, highlighting their role in antibiotic resistance and the emergence of new variants such as TEM-1, SHV-1, OXA-1, and AmpC.
Molecular characterization of extended spectrum β -lactamases enterobacteriaceae causing lower urinary tract infection among pediatric population.
The study identified bla CTX-MG1, bla CTX-MG9, bla CTX-MG2, bla CTX-MG8, bla TEM, and bla SHV as the main genes responsible for extended-spectrum beta-lactamase (ESBL) resistance in Enterobacteriaceae causing urinary tract infections in pediatric populations in Qatar.
Superficieibacter electus gen. nov., sp. nov., an Extended-Spectrum β-Lactamase Possessing Member of the Enterobacteriaceae Family, Isolated From Intensive Care Unit Surfaces.
The study identifies multiple antibiotic resistance genes in the newly described species Superficieibacter electus, including beta-lactamases, aminoglycoside modifying enzymes, and others, indicating its ability to resist various antibiotics.
Extended-spectrum beta-lactamase-encoding genes are spreading on a wide range of Escherichia coli plasmids existing prior to the use of third-generation cephalosporins.
The study identifies various extended-spectrum beta-lactamase (ESBL)-encoding genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-9, bla CTX-M-3, bla CTX-M-2, bla SHV-12, bla SHV-2, bla SHV-5, bla SHV-3, bla TEM-52, bla TEM-24, bla TEM-21, and bla TEM-3, which are found on a wide range of Escherichia coli plasmids. These genes are responsible for resistance to various β-lactam antibiotics.
Extended-spectrum beta-lactamase-encoding genes are spreading on a wide range of Escherichia coli plasmids existing prior to the use of third-generation cephalosporins.
The study identifies various extended-spectrum beta-lactamase (ESBL)-encoding genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-9, bla CTX-M-3, bla CTX-M-2, bla SHV-12, bla SHV-2, bla SHV-5, bla SHV-3, bla TEM-52, bla TEM-24, bla TEM-21, and bla TEM-3, which are found on a wide range of Escherichia coli plasmids. These genes are responsible for resistance to various β-lactam antibiotics.
Extended-spectrum beta-lactamase-encoding genes are spreading on a wide range of Escherichia coli plasmids existing prior to the use of third-generation cephalosporins.
The study identifies various extended-spectrum beta-lactamase (ESBL)-encoding genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-9, bla CTX-M-3, bla CTX-M-2, bla SHV-12, bla SHV-2, bla SHV-5, bla SHV-3, bla TEM-52, bla TEM-24, bla TEM-21, and bla TEM-3, which are found on a wide range of Escherichia coli plasmids. These genes are responsible for resistance to various β-lactam antibiotics.
Extended-spectrum beta-lactamase-encoding genes are spreading on a wide range of Escherichia coli plasmids existing prior to the use of third-generation cephalosporins.
The study identifies various extended-spectrum beta-lactamase (ESBL)-encoding genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-9, bla CTX-M-3, bla CTX-M-2, bla SHV-12, bla SHV-2, bla SHV-5, bla SHV-3, bla TEM-52, bla TEM-24, bla TEM-21, and bla TEM-3, which are found on a wide range of Escherichia coli plasmids. These genes are responsible for resistance to various β-lactam antibiotics.
Tracing back multidrug-resistant bacteria in fresh herb production: from chive to source through the irrigation water chain.
The study identified multidrug-resistant bacteria in irrigation water and chive, highlighting the role of water quality in the transmission of antibiotic-resistant bacteria. Key resistance genes included blaCTX-M-15, mphA, and tet(A).
A Population-Based Surveillance Study of Shared Genotypes of Escherichia coli Isolates from Retail Meat and Suspected Cases of Urinary Tract Infections.
The study identified shared genotypes of E. coli isolates from retail meat and urinary tract infections, highlighting the potential transmission of uropathogenic E. coli from poultry to humans. It also detected bla TEM genes in ampicillin-resistant E. coli isolates from both meat and human sources.
Molecular Characterization of Extended-Spectrum β-Lactamase-Producing Multidrug Resistant Escherichia coli From Swine in Northwest China.
The study identified multiple β-lactamase genes, including bla CTX-M, bla TEM, bla SHV, bla OXA-48, and bla KPC-2, as well as PMQR genes such as qnrS and aac(6')-Ib-cr, in multidrug-resistant E. coli isolates from swine in Northwest China.
Dynamics of antimicrobial resistance in intestinal Escherichia coli from children in community settings in South Asia and sub-Saharan Africa.
The study identified multiple AMR genes in aEPEC isolates from children in South Asia and sub-Saharan Africa, highlighting the prevalence of resistance to multiple antibiotics, including ampicillin, streptomycin, trimethoprim/sulphamethoxazole, and tetracycline.
Molecular Cloning and Docking of speB Gene Encoding Cysteine Protease With Antibiotic Interaction in Streptococcus pyogenes NBMKU12 From the Clinical Isolates.
The study identified the TEM gene, a beta-lactamase, in the S. pyogenes NBMKU12 isolate, which confers resistance to penicillin-G. The speB gene, encoding a cysteine protease, was cloned and characterized, showing proteolytic activity against various substrates.
Molecular characterization and epidemiology of carbapenem non-susceptible Enterobacteriaceae isolated from the Eastern region of Heilongjiang Province, China.
The study identified bla KPC-2, bla NDM, bla SHV, bla TEM, and bla CTX-M-15 as the main drug resistance genes in carbapenem non-susceptible Enterobacteriaceae (CNSE) isolates from the Eastern region of Heilongjiang Province, China. The primary resistance mechanism was the production of carbapenemases and extended-spectrum beta-lactamases.
Characterization of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae From Retail Food in China.
The study identified blaTEM, blaCTX-M, blaSHV, and blaOXA genes as the main contributors to extended-spectrum beta-lactamase (ESBL) production in Enterobacteriaceae isolated from retail foods in China. These genes were found to confer resistance to multiple antibiotics, highlighting the significance of these resistance mechanisms in food-borne pathogens.
Variant O89 O-Antigen of E. coli Is Associated With Group 1 Capsule Loci and Multidrug Resistance.
The study identified a novel O89 O-antigen locus in E. coli strain 26561, which is associated with group 1 capsule (G1C) and multidrug resistance. The strain exhibits a mucoid and viscous phenotype, and possesses multiple AMR genes including blaCTX-M-14, blaTEM-1, aph(3")-Ib, strA, aph(6)-Id, strB, aph(3′)-Ia, sul2, tetA(B), and catA1. Mutations in gyrA (S83L, D87N) and parC (S80I) contribute to quinolone resistance.
Characterization of beta-lactamase- and efflux pump-mediated multiple antibiotic resistance in Salmonella Typhimurium.
The study identified blaTEM as a beta-lactamase gene contributing to ampicillin and ceftriaxone resistance in Salmonella Typhimurium. The gene was experimentally validated through beta-lactamase activity assays.
Molecular characteristics of extended-spectrum β-lactamase-producing Escherichia coli isolated from the rivers and lakes in Northwest China.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-14, bla CTX-M-9, bla CTX-M-123, bla CTX-M-15, bla CTX-M-27, bla CTX-M-1, and bla CTX-M-65, as well as bla TEM-1 and bla SHV-12. Additionally, the PMQR gene aac(6′)-Ib-cr was found to be the most prevalent. These genes were associated with resistance to various beta-lactam and aminoglycoside antibiotics.
Molecular characterization, antimicrobial resistance and clinico-bioinformatics approaches to address the problem of extended-spectrum beta-lactamase-producing Escherichia coli in western Saudi Arabia.
The study identified bla CTX-M and bla TEM genes as the primary resistance mechanisms in ESBL-producing E. coli isolates from western Saudi Arabia, with bla CTX-M-1 being the most prevalent variant.
Superintendence of antimicrobial resistance observed in bacterial flora isolated from human faecal carriage in Vellore, India.
The study identified the presence of ESBL genes such as blaCTX-M, blaTEM, and blaSHV in Enterobacteriaceae and Pseudomonas aeruginosa isolates from faecal samples, indicating significant antimicrobial resistance.
Interplay Between the Phenotype and Genotype, and Efflux Pumps in Drug-Resistant Strains of Riemerella anatipestifer.
The study identified multiple AMR genes and mutations in Riemerella anatipestifer, including aac(6')-Ib, aadA1, aadA2, aadA5, aac(3')-IIc, aac(3')-IV, aph(3')-VII, aph(2')-Ib, bla TEM, bla OXA, tet(A), tet(B), sul1, sul2, sul3, cat2, cmlA, floR, emrF, qnrS, and qnrD. Additionally, mutations in gyrA and parC were found to confer fluoroquinolone resistance.
Characterization of Pathogenic Bacteria Isolated from Sudanese Banknotes and Determination of Their Resistance Profile.
The study identified multidrug-resistant bacteria on Sudanese banknotes, including strains carrying bla CTX-M, bla TEM, and mecA genes, indicating resistance to various beta-lactam antibiotics and methicillin.
Antimicrobial Resistance in ESBL-Producing E. coli Isolates from Companion Animals
The study identifies several novel beta-lactamase genes, including bla_SFO, bla_Cph, bla_VIM, bla_Act, bla_MIR, bla_MOX, and bla_PAO, along with commonly encountered genes like bla_CTX-M-15, bla_TEM-1B, and bla_OXA-1, in ESBL-producing E. coli isolates from companion animals.
Genotypic and phenotypic characterization of Salmonella enterica subsp. enterica serovar Typhimurium monophasic variants isolated in Thailand and Japan.
The study identified several antimicrobial resistance genes in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variants, including blaTEM, aadA, strA, strB, tet(A), tet(B), tet(G), sul1, sul2, sul3, and floR, which confer resistance to ampicillin, streptomycin, oxytetracycline, sulfisoxazole, and chloramphenicol.
The Transferable Resistome of Produce.
The study identified multiple tetracycline resistance genes, beta-lactamases, and other resistance determinants in E. coli isolates from produce, highlighting the potential for horizontal gene transfer and the significance of the produce microbiome as a reservoir of antibiotic resistance genes.
High frequency and molecular epidemiology of metallo-β-lactamase-producing gram-negative bacilli in a tertiary care hospital in Lahore, Pakistan.
The study identified the prevalence of metallo-beta-lactamase (MBL)-producing gram-negative bacilli in a tertiary care hospital in Lahore, Pakistan. It found that bla TEM, bla SHV, bla OXA, bla IMP-1, and bla VIM genes were frequently present in imipenem-resistant isolates, indicating the coexistence of extended-spectrum beta-lactamase (ESBL) and MBL genes.
Analysis of bacteriological pollution and the detection of antibiotic resistance genes of prevailing bacteria emanating from pig farm seepage.
The study identified several antibiotic resistance genes in bacteria isolated from pig farm seepage, including aadA, aa(6')-le-aph(2")-la, aph(2")-lb, aph(2")-lc, aph(2")-ld, aph(3")-llla, ant(4')-la, VanA, VanB, VanC2/C3, InuA, InuB, InuC, InuF, blaTEM, blaSHV, blaOXA, OtrA, OtrB, Sul1, and Sul2. These genes conferred resistance to various antibiotics such as penicillins, sulfamethoxazole, tetracyclines, and glycopeptides.
Succession and persistence of microbial communities and antimicrobial resistance genes associated with International Space Station environmental surfaces.
The study identified the presence of antimicrobial resistance genes such as bla and vanA in the microbial communities associated with International Space Station environmental surfaces, indicating the persistence of these resistance mechanisms in a closed-system environment.
Salmonella enterica Serovar Typhi in Bangladesh: Exploration of Genomic Diversity and Antimicrobial Resistance.
The study identified several AMR genes and mutations in S. Typhi isolates from Bangladesh, including blaTEM-1B, blaCTX-M-15, catA1, dfrA7, sul1, sul2, qnrS1, strA, strB, tet(A), tet(B), and mutations in gyrA and parE associated with ciprofloxacin resistance.
Do the clonally different Escherichia coli isolates causing different infections in a HIV positive patient affect the selection of antibiotics for their treatment?
The study identified multiple drug-resistance genes in clonally different Escherichia coli isolates from a HIV-positive patient, including bla TEM, bla CTX-M, bla OXA, bla CIT-M, sul1, sul2, and dfrA7, which conferred resistance to various antibiotics.
Role of TEM-1 beta-lactamase in the Predominance of Ampicillin-Sulbactam-Nonsusceptible Escherichia coli in Japan.
The study identifies TEM-1 beta-lactamase as a key contributor to ampicillin-sulbactam nonsusceptibility in E. coli, highlighting its role in reducing susceptibility through enzymatic degradation of the antibiotic.
Emerging Multidrug-Resistant Hybrid Pathotype Shiga Toxin-Producing Escherichia coli O80 and Related Strains of Clonal Complex 165, Europe.
The study identifies multidrug-resistant hybrid pathotype Shiga toxin-producing E. coli O80 strains belonging to clonal complex 165, which harbor a mosaic plasmid with genes conferring resistance to multiple antibiotics, including beta-lactams, tetracyclines, sulfonamides, trimethoprim, kanamycin, streptomycin, and colistin.
Antibiotic-Resistant Bacteria in Greywater and Greywater-Irrigated Soils.
The study identified tetracycline-resistant bacteria in treated greywater and greywater-irrigated soils, with tet39 being the most prevalent tetracycline resistance gene. Several beta-lactamase genes, including blaTEM, blaCTXM-32, blaOXA-2, and blaOXA-10, were also detected, indicating multidrug resistance.
Antibiotic-resistant indicator bacteria in irrigation water: High prevalence of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli.
The study identified a high prevalence of ESBL-producing E. coli in irrigation water, with blaCTX-M-1 and blaCTX-M-15 being the most common ESBL genes. These genes conferred resistance to extended-spectrum cephalosporins, and additional resistance genes such as blaTEM-1B, sul1, sul2, dfrA1, dfrA14, dfrA17, aadA1, aadA5, mph(A), qnrS1, and tet(A) were also detected.
Characterization of Gene Families Encoding Beta-Lactamases of Gram-Negative Rods Isolated from Ready-to-Eat Vegetables in Mexico City.
The study identified various beta-lactamase genes, including blaBIL, blaSHV, blaCTX, blaDHA, blaVIM, blaOXA, blaIMP, blaKPC, and blaTEM, which confer resistance to beta-lactam antibiotics in Enterobacteriaceae isolated from ready-to-eat vegetables in Mexico City.
Co-production of AmpC and extended spectrum beta-lactamases in cephalosporin-resistant Acinetobacter baumannii in Egypt.
The study identifies the prevalence of extended-spectrum beta-lactamases (ESBLs) and AmpC beta-lactamases in cephalosporin-resistant Acinetobacter baumannii isolates in Egypt, highlighting the co-production of blaTEM, blaPER, blaSHV, blaVEB, and blaADC genes contributing to beta-lactam resistance.
Study of class 1 integrons in multidrug-resistant uropathogenic Escherichia coli isolated from different hospitals in Karachi.
The study identified CTX-M1, TEM, and SHV as the predominant ESBL genes in MDR uropathogenic E. coli, along with class 1 integrons carrying intI1, qacEΔ1, and sul1.
Zoonotic multidrug-resistant microorganisms among small companion animals in Germany.
The study identified ESBL-producing Enterobacteriaceae and MRSA in companion animals, highlighting the presence of beta-lactam resistance genes such as bla TEM, bla CTX-M, bla SHV, and bla CMY-2, as well as methicillin resistance genes mecA and mecC in various staphylococcal species.
Travel to Asia is a strong predictor for carriage of cephalosporin resistant E. coli and Klebsiella spp. but does not explain everything; prevalence study at a Norwegian hospital 2014-2016.
The study identified bla CTX-M-15, bla CTX-M-55, bla CTX-M-27, bla OXA-1, bla CTX-M-14, bla CTX-M-1, bla CTX-M-3, bla TEM-33, bla DHA-1, and bla CMY-42 as the main genes responsible for extended-spectrum cephalosporin resistance in E. coli and Klebsiella spp. Travel to Asia was a strong predictor for carriage of these resistant strains.
Plasmid-mediated beta-lactamase (TEM-7) involved in resistance to ceftazidime and aztreonam.
Plasmid-mediated beta-lactamase (TEM-7) involved in resistance to ceftazidime and aztreonam.
Plasmid-mediated beta-lactamase (TEM-7) involved in resistance to ceftazidime and aztreonam.
Plasmid-mediated beta-lactamase (TEM-7) involved in resistance to ceftazidime and aztreonam.
Plasmid-mediated beta-lactamase (TEM-7) involved in resistance to ceftazidime and aztreonam.
Plasmid-mediated beta-lactamase (TEM-7) involved in resistance to ceftazidime and aztreonam.
Plasmid-mediated beta-lactamase (TEM-7) involved in resistance to ceftazidime and aztreonam.
Alarming levels of antimicrobial resistance among sepsis patients admitted to ICU in a tertiary care hospital in India - a case control retrospective study.
The study identified high levels of antimicrobial resistance in E. coli isolates from sepsis patients in an Indian ICU, with a significant prevalence of ESBL genes including CTX-M15, CTX-M9, TEM, SHV, and OXA-1.
Escherichia coli bacteriuria in pregnant women in Ghana: antibiotic resistance patterns and virulence factors.
The study identified blaTEM as a major contributor to ampicillin resistance and aph(3)-Ia as a determinant of gentamicin resistance in E. coli isolates from pregnant women in Ghana.
Epidemiology of Bloodstream Infections Caused by Escherichia coli and Klebsiella pneumoniae That Are Piperacillin-Tazobactam-Nonsusceptible but Ceftriaxone-Susceptible.
The study identified bla TEM-1, bla SHV-1, and bla OXA-1 as the primary beta-lactamase genes responsible for piperacillin-tazobactam non-susceptibility in Escherichia coli and Klebsiella pneumoniae isolates, without the presence of ESBLs, AmpC-beta-lactamases, or carbapenemases.
Molecular characterisation of the NDM-1-encoding plasmid p2189-NDM in an Escherichia coli ST410 clinical isolate from Ghana.
The study identifies the NDM-1-producing E. coli strain EC2189 carrying the plasmid p2189-NDM, which contains multiple AMR genes including blaNDM-1, aadA1, aac(6')-Ib, sul3, dfrA12, cmlA1, blaCTX-M-15, blaTEM-1A, and blaOXA-9. The plasmid p2189-NDM exhibits a unique genetic structure and is phylogenetically distinct from previously identified blaNDM-1-positive plasmids.
Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain.
The study shows that Acinetobacter baumannii A118 can acquire antibiotic resistance genes from other species through natural transformation, leading to increased resistance to various antibiotics such as meropenem, imipenem, and sulfamethoxazole.
Genomic and Virulence Characterization of Intrauterine Pathogenic Escherichia coli With Multi-Drug Resistance Isolated From Cow Uteri With Metritis.
The study identified multiple beta-lactamase genes, including bla CTX-M, bla CMY, bla TEM, and ampC, in intrauterine pathogenic E. coli (IUPEC) isolates from cows with metritis, which conferred resistance to cephalosporins like cefotaxime and ceftiofur.
Diarrheal bacterial pathogens and multi-resistant enterobacteria in the Choqueyapu River in La Paz, Bolivia.
The study identified multidrug-resistant Enterobacteriaceae in the Choqueyapu River, including E. coli and Enterobacter cloacae carrying bla CTX-M, bla KPC, bla NDM, bla VIM, and bla OXA-48 genes, highlighting the environmental spread of antibiotic resistance.
Antimicrobial resistance genes in Salmonella and Escherichia coli isolates from chicken droppings in Nairobi, Kenya.
The study identified TEM and CTX-M beta-lactamase genes in Escherichia coli and Salmonella isolates from chicken droppings in Nairobi, Kenya, contributing to amoxicillin resistance.
Antimicrobial resistance of Escherichia coli and Enterococcus spp. isolated from Estonian cattle and swine from 2010 to 2015.
The study identified bla CMY-1, bla CMY-2, and bla TEM-52C genes in E. coli isolates from Estonian cattle and swine, indicating resistance to beta-lactam antibiotics. High levels of resistance to various antibiotics were observed in E. coli and Enterococcus spp. from both animal sources.
Co-outbreak of multidrug resistance and a novel ST3006 Klebsiella pneumoniae in a neonatal intensive care unit: A retrospective study.
The study identified two clones of multidrug-resistant Klebsiella pneumoniae, ST37 and ST3006, in a neonatal intensive care unit. ST37 harbored multiple resistance genes, including OXA-33, TEM-1, SHV-11, and others, while ST3006 carried fewer resistance genes. Whole-genome sequencing revealed the presence of various antibiotic resistance genes and genomic islands.
Extensive drug resistant Salmonella enterica serovar Senftenberg carrying blaNDM encoding plasmid p5558 (IncA/C) from India.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Salmonella enterica serovar Senftenberg isolate, including blaNDM-1, blaTEM-1, blaOXA-9, blaCMY-2, aac(6')-Ia, aac(6')-Ib, aph(3')-Ib, aph(6')-Ib, ant(3'')-Ia, sul-1, sul-2, and florR. Additionally, mutations in gyrA (S83Y, D87G) and parC (S80I) were associated with fluoroquinolone resistance.
High Prevalence of Multidrug-Resistant Klebsiella pneumoniae Harboring Several Virulence and beta-lactamase Encoding Genes in a Brazilian Intensive Care Unit.
The study identified a high prevalence of multidrug-resistant Klebsiella pneumoniae isolates carrying various beta-lactamase genes (bla KPC, bla TEM, bla SHV, bla OXA-1, and bla CTX-M-1) and efflux pump genes (AcrAB, tol C, mdt K) along with outer membrane porin genes (Omp K35 and Omp K36).
Diversity of Plasmids and Genes Encoding Resistance to Extended Spectrum Cephalosporins in Commensal Escherichia coli From Dutch Livestock in 2007-2017.
The study identified 22 different ESBL/pAmpC genes in commensal E. coli from Dutch livestock, with bla CTX-M-1 being the most prevalent. Other notable genes included bla CMY-2, bla TEM-52, bla SHV-12, and bla CTX-M-15. The study also highlighted the role of plasmids in the dissemination of these resistance genes.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Prevalence of Extended-Spectrum-β-Lactamase-Producing Escherichia coli in Imported Frozen Freshwater Fish in Eastern Province of Saudi Arabia.
The study found that 27.2% of imported frozen freshwater fish samples in Saudi Arabia contained ESBL-producing E. coli, with bla CTX-M being the most prevalent ESBL gene, followed by bla SHV and bla TEM.
Cross-Border Transmission of Salmonella Choleraesuis var. Kunzendorf in European Pigs and Wild Boar: Infection, Genetics, and Evolution.
The study identified multiple antimicrobial resistance genes in Salmonella Choleraesuis isolates, including aadA1, catA1, cmlA1, floR, mph(B), strA, strB, sul1, sul2, sul3, tet(A), tet(B), dfrA1, aph(3')-Ia, lnu(B), and blaTEM-1. These genes conferred resistance to various antibiotics such as streptomycin, chloramphenicol, florfenicol, erythromycin, sulfamethoxazole, tetracycline, trimethoprim, gentamicin, lincomycin, and ampicillin.
Clinical outcome of Escherichia coli bloodstream infection in cancer patients with/without biofilm formation: a single-center retrospective study.
The study identified bla CTX-M-15 and bla TEM-52 as prevalent genes in ESBL-EC isolates causing bloodstream infections in cancer patients, highlighting their association with biofilm formation and increased mortality.
Longitudinal Assessment of Antibiotic Resistance in Fecal Escherichia coli in Tanzanian Children.
The study found high prevalence of multidrug-resistant (MDR) Escherichia coli in Tanzanian children, with resistance to ampicillin, cefazolin, cotrimoxazole, and other antibiotics. TEM beta-lactamase was identified as a key resistance mechanism.
Transcriptome analysis of beta-lactamase genes in diarrheagenic Escherichia coli.
Multi-state study of Enterobacteriaceae harboring extended-spectrum beta-lactamase and carbapenemase genes in U.S. drinking water.
The study identified bla CTX-M, bla SHV, bla TEM, and bla OXA-48 genes in coliform-positive drinking water samples across six U.S. states, highlighting the presence of extended-spectrum beta-lactamase and carbapenemase genes in non-Enterobacteriaceae species, indicating potential community exposure risks.
Detection of Extended- Spectrum Beta-Lactamase producing Escherichia coli from mesenteric lymph nodes of wild boars (Sus scrofa).
The study detected an ESBL-producing E. coli isolate (WB-21L) from wild boars, which was positive for the blaTEM gene and exhibited resistance to multiple antibiotics.
Nasal Resistome Development in Infants With Cystic Fibrosis in the First Year of Life.
The study identified various antimicrobial resistance genes in the nasal microbiome of infants with cystic fibrosis, including beta-lactamases, chloramphenicol efflux pumps, tetracycline resistance proteins, and enzymes involved in folic acid synthesis inhibition.
Characterisation of antibiotic resistance of Salmonella isolated from dog treats in Japan.
The study identified the presence of antibiotic-resistant Salmonella in dog treats in Japan, including the blaTEM gene, aadA1, aadA2, tetB, floR, catA1, dfrA12, and intI1 genes, indicating multidrug resistance.
Detection of critical antibiotic resistance genes through routine microbiome surveillance.
The study identifies various antibiotic resistance genes (ARGs) associated with multidrug resistance, including macrolide, beta-lactam, tetracycline, and methicillin resistance genes, highlighting the presence of these genes in postmortem microbiome samples.
Extended Spectrum Beta-Lactamase-Producing Gram-Negative Bacteria Recovered From an Amazonian Lake Near the City of Belém, Brazil.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-2, bla TEM, and bla SHV, in multidrug-resistant gram-negative bacteria from an Amazonian lake. These genes were associated with resistance to cephalosporins and other beta-lactam antibiotics.
Prevalence of antimicrobial resistance and potential pathogenicity, and possible spread of third generation cephalosporin resistance, in Escherichia coli isolated from healthy chicken farms in the region of Dakar, Senegal.
The study identified various AMR genes and mutations in E. coli isolates from healthy chicken farms in Senegal, including bla CTX-M, bla CMY-2, tetA, dfrA1, dfrA7, aadA1, qnrB, and bla TEM, as well as mutations in gyrA and parC genes contributing to ciprofloxacin resistance.
Loss and Gain in the Evolution of the Salmonella enterica Serovar Gallinarum Biovar Pullorum Genome.
The study identifies multiple multidrug resistance plasmids in Salmonella Pullorum, including pSPUR1, pSPUR2, pSPUR3, pSPUR4, and pSPUR5, which confer resistance to various antibiotics such as trimethoprim, streptomycin, sulfonamide, and tetracycline.
Phenotypic and Genotypic Characterization of Acinetobacter spp. Panel Strains: A Cornerstone to Facilitate Antimicrobial Development.
The study characterized various AMR genes in Acinetobacter spp. including blaPER-1, blaTEM-1D, blaADC-31, blaOXA-82, aac(3')-Ia, aac(6')-Il, aph(3')-Ic, strAB, and others. Mutations in gyrA and parC were associated with fluoroquinolone resistance. Overexpression of efflux pumps like adeB and adeJ contributed to multidrug resistance.
Non-typhoidal Salmonella blood stream infection in Kuwait: Clinical and microbiological characteristics.
The study identified several AMR genes and mutations in non-typhoidal Salmonella isolates from Kuwait, including aac(6')-Iaa_1, aph(3'')-Ib_5, aph(3')-Ia_1, aph(6)-Id_1, blaCARB-2_1, blaTEM-1B_1, dfrA5_1, floR_2, sul2_2, tet(A)_6, tet(G)_2, and mutations in the gyrA gene. These genes and mutations were associated with resistance to various antibiotics such as aminoglycosides, beta-lactams, trimethoprim, chloramphenicol, sulfamethoxazole, tetracycline, and fluoroquinolones.
Fecal Colonization With Multidrug-Resistant E. coli Among Healthy Infants in Rural Bangladesh.
The study identified the presence of multidrug-resistant (MDR) Escherichia coli in the feces of healthy infants in rural Bangladesh, with a high prevalence of extended-spectrum beta-lactamase (ESBL)-producing strains. The most prevalent ESBL gene was bla CTX-M-group-1, followed by bla TEM and bla OXA-1.
Gamma Irradiation Influences the Survival and Regrowth of Antibiotic-Resistant Bacteria and Antibiotic-Resistance Genes on Romaine Lettuce.
The study investigated the impact of gamma irradiation on antibiotic-resistant bacteria and antibiotic resistance genes (ARGs) on romaine lettuce. It found that irradiation significantly reduced the abundance of certain ARGs, including those conferring resistance to tetracycline.
Gamma Irradiation Influences the Survival and Regrowth of Antibiotic-Resistant Bacteria and Antibiotic-Resistance Genes on Romaine Lettuce.
The study investigated the impact of gamma irradiation on antibiotic-resistant bacteria and antibiotic resistance genes (ARGs) on romaine lettuce. It found that irradiation significantly reduced the abundance of certain ARGs, including those conferring resistance to tetracycline.
High prevalence of CTX-M-1 group in ESBL-producing enterobacteriaceae infection in intensive care units in southern Chile.
The study identified a high prevalence of CTX-M-1 group beta-lactamases in ESBL-producing enterobacteriaceae in intensive care units in southern Chile, highlighting the significance of these enzymes in the epidemiology of antimicrobial resistance.
Despite Predominance of Uropathogenic/Extraintestinal Pathotypes Among Travel-acquired Extended-spectrum beta-lactamase-producing Escherichia coli, the Most Commonly Associated Clinical Manifestation Is Travelers' Diarrhea.
The study identifies various beta-lactamase genes (TEM, OXA, SHV, CTX-M group 1, and CTX-M group 9) in travel-acquired ESBL-producing E. coli strains, highlighting their role in resistance to multiple β-lactam antibiotics. The most common clinical manifestation associated with these strains was travelers' diarrhea rather than urinary tract infections.
Genomic Investigation of the Emergence of Invasive Multidrug-Resistant Salmonella enterica Serovar Dublin in Humans and Animals in Canada.
The study identifies multiple AMR genes and mutations in multidrug-resistant Salmonella enterica serovar Dublin isolates from Canada, highlighting the role of IS 26 in plasmid hybridization and the emergence of MDR strains.
Piperacillin-Tazobactam (TZP) Resistance in Escherichia coli Due to Hyperproduction of TEM-1 beta-lactamase Mediated by the Promoter Pa/Pb.
The study identifies bla TEM-1b gene with the strong promoter Pa/Pb as the cause of piperacillin-tazobactam resistance in E. coli RJ904, demonstrating that hyperproduction of TEM-1 beta-lactamase mediated by the Pa/Pb promoter leads to high resistance to TZP.
Antibiotic Susceptibility Patterns and Prevalence of Some Extended Spectrum Beta-Lactamases Genes in Gram-Negative Bacteria Isolated from Patients Infected with Urinary Tract Infections in Al-Najaf City, Iraq.
The study identified the prevalence of blaTEM, blaSHV, and blaCTX-M genes in gram-negative bacteria isolated from urinary tract infections in patients with chronic kidney disease (CKD) in Al-Najaf City, Iraq. These genes were more commonly detected in CKD patients compared to those without kidney disease (WKD).
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
Molecular Characterization of Extended Spectrum β-lactamase and Carbapenemase Producing Klebsiella pneumoniae from a Tertiary Care Hospital.
The study identified bla NDM-1 as a significant carbapenem resistance gene in Klebsiella pneumoniae isolates, with 9.7% of carbapenem-resistant isolates carrying this gene. Additionally, bla TEM and bla SHV genes were prevalent among ESBL-producing isolates.
Global phylogenomics of multidrug-resistant Salmonella enterica serotype Kentucky ST198.
The study identifies multiple AMR genes and mutations in multidrug-resistant Salmonella enterica serotype Kentucky ST198, including genes such as blaTEM-1, aacA4, aadA1, sul1, tetA, catA1, mph(A), blaCTX-M-1, blaOXA-48, blaNDM-1, blaCMY-2, and dfrA12, along with mutations in gyrA and parC that confer resistance to various antibiotics.
Diverse Commensal Escherichia coli Clones and Plasmids Disseminate Antimicrobial Resistance Genes in Domestic Animals and Children in a Semirural Community in Ecuador.
The study identified various antimicrobial resistance (AMR) genes in commensal Escherichia coli isolates from children and domestic animals in a semirural community in Ecuador. These genes included blaTEM-1B, dfrA8, qnrB19, strA, strB, tetA, tetB, sul1, sul2, and others, contributing to resistance against multiple antibiotics such as ampicillin, trimethoprim, tetracycline, and sulfamethoxazole. The research highlights the role of plasmids in disseminating these AMR genes and emphasizes the complexity of AMR transmission in such environments.
Infection caused by Klebsiella pneumoniae ST11 in a patient after craniectomy.
The study identifies blaSHV-11, blaTEM-1, blaCTX-M-15, and blaKPC-3 genes in multidrug-resistant K. pneumoniae ST11 isolates from a neurosurgical patient, highlighting their role in resistance to beta-lactam and carbapenem antibiotics.
Multiomics Assessment of Gene Expression in a Clinical Strain of CTX-M-15-Producing ST131 Escherichia coli.
The study identifies multiple AMR genes and mutations in the CTX-M-15-producing ST131 E. coli strain C999, including beta-lactamases (blaCTX-M-15, blaTEM-1, blaOXA-1), aminoglycoside resistance gene (aac(6')-Ib-cr), tetracycline resistance gene (tet(A)), sulfonamide resistance gene (sul1), and aadA5 gene cassette. Mutations in gyrA and parC contribute to fluoroquinolone resistance.
Multiomics Assessment of Gene Expression in a Clinical Strain of CTX-M-15-Producing ST131 Escherichia coli.
The study identifies multiple AMR genes and mutations in the CTX-M-15-producing ST131 E. coli strain C999, including beta-lactamases (blaCTX-M-15, blaTEM-1, blaOXA-1), aminoglycoside resistance gene (aac(6')-Ib-cr), tetracycline resistance gene (tet(A)), sulfonamide resistance gene (sul1), and aadA5 gene cassette. Mutations in gyrA and parC contribute to fluoroquinolone resistance.
Ceftriaxone-resistant Salmonella enterica serotype Typhi in a pregnant traveller returning from Karachi, Pakistan to Denmark, 2019.
The study reports a ceftriaxone-resistant Salmonella Typhi isolate carrying multiple resistance genes, including blaCTX-M-15, blaTEM-1B, qnrS1, sul1, sul2, dfrA7, aph[3]-1b, aph[6]-1d, aac[6]-1aa, and catA1. Additionally, a fluoroquinolone resistance mutation (gyrA S83F) was identified.
Genomic characterization of Escherichia coli LCT-EC001, an extremely multidrug-resistant strain with an amazing number of resistance genes.
The study identifies 68 antibiotic resistance determinants in E. coli LCT-EC001, including 8 beta-lactamase genes (blaTEM-1, blaCTX-M-14, blaKPC-2), 31 multidrug efflux system genes, 6 outer membrane transport system genes, 4 aminoglycoside-modifying enzyme genes, 10 two-component regulatory system genes, and 9 other enzyme or transcriptional regulator genes.
Evaluation of the Synergy of Ceftazidime-Avibactam in Combination with Meropenem, Amikacin, Aztreonam, Colistin, or Fosfomycin against Well-Characterized Multidrug-Resistant Klebsiella pneumoniae and Pseudomonas aeruginosa.
The study evaluated the synergy of ceftazidime-avibactam (CZA) in combination with other antibiotics against multidrug-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa. Several AMR genes, including blaKPC-2, blaKPC-3, blaCTX-M-15, and others, were identified as conferring resistance to CZA and other antibiotics.
Molecular detection of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates of chicken origin from East Java, Indonesia.
The study identified the presence of ESBL genes (bla TEM, bla CTX-M, and bla SHV) in K. pneumoniae isolates from chicken farms in East Java, Indonesia, indicating multidrug resistance.
Phenotypic and genotypic characterization of multi-drug-resistant Escherichia coli isolates harboring bla(CTX-M) group extended-spectrum beta-lactamases recovered from pediatric patients in Shenzhen, southern China.
The study identified various bla CTX-M subtypes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-90, and others, as well as bla TEM, bla SHV, bla GES, bla CARB, bla NDM-1, bla KPC, and mcr-1, which contribute to multidrug resistance in E. coli isolates from pediatric patients in Shenzhen, China.
Associations between antimicrobial use and the faecal resistome on broiler farms from nine European countries.
The study identified several antimicrobial resistance genes associated with antimicrobial use on broiler farms, including bla TEM, erm (B), tet (W), aadA cluster, cmx, and dfrA1.
Enterohaemorrhagic Escherichia coli O121:H19 acquired an extended-spectrum beta-lactamase gene during the development of an outbreak in two nurseries.
The study identifies the acquisition of the ESBL gene bla CTX-M-55 by EHEC O121:H19 during an outbreak, highlighting the spread of antimicrobial resistance in nursery settings.
Antimicrobial resistance, virulence & plasmid profiles among clinical isolates of Shigella serogroups.
The study identified multiple antimicrobial resistance genes including bla OXA-1, bla TEM-1B, qnr S1, dfr A1, aad A1, sul II, tet B, and cat A1 in Shigella isolates. Additionally, novel mutations in gyr A, gyr B, par C, and par E genes were observed, contributing to quinolone resistance.
Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection.
The study presents a nanopore metagenomics method for rapid detection of bacterial pathogens and antibiotic resistance genes in lower respiratory infections, achieving high sensitivity and specificity through host DNA depletion and real-time sequencing.
Metal impacts on the persistence and proliferation of β-lactam resistance genes in Xiangjiang River, China.
The study identifies and characterizes the persistence and proliferation of various β-lactam resistance genes (blaTEM, blaVIM, blaSHV, blaGES, blaDHA, blaOXA-1, blaOXA-2, blaOXA-10, blaCMY-2, and blaampC) in the Xiangjiang River, highlighting the impact of heavy metals on their distribution and the role of bacterial communities in their persistence.
Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods.
The study identified various AMR genes and mutations in Salmonella enterica serovar Typhimurium, including aadA, strAB, blaTEM, blaCARB, floR, cmlA1, catA1, qnrB19, sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, tetA, tetB, tetC, tetG, and mutations in gyrA. These genes and mutations were validated through whole genome sequencing and phenotypic ASTs.
Characterization and whole genome sequencing of closely related multidrug-resistant Salmonella enterica serovar Heidelberg isolates from imported poultry meat in the Netherlands.
The study identified blaCMY-2, qnrB19, blaCTX-M-2, blaCTX-M-8, and blaTEM-1B as key resistance genes in multidrug-resistant Salmonella enterica serovar Heidelberg isolates from imported poultry meat in the Netherlands. Mutations in gyrA (S83F) and parC (T57S) were also linked to ciprofloxacin and nalidixic acid resistance.
Genotypic and Phenotypic Characterization of Antimicrobial Resistance in Neisseria gonorrhoeae: a Cross-Sectional Study of Isolates Recovered from Routine Urine Cultures in a High-Incidence Setting.
The study identified bla TEM-1b as a key determinant of penicillin resistance and tet (M) as a key determinant of tetracycline and doxycycline resistance in Neisseria gonorrhoeae isolates. Mutations in gyrA and parC were associated with quinolone resistance, while rpsJ V57M and mtrR promoter mutations contributed to tetracycline and azithromycin resistance, respectively.
Resistance of Neisseria gonorrhoeae isolates to beta-lactam antibiotics (benzylpenicillin and ceftriaxone) in Russia, 2015-2017.
The study identified mutations in penA, ponA, mtrR, and porB genes, as well as the presence of bla TEM plasmids, which contribute to benzylpenicillin resistance in Neisseria gonorrhoeae isolates from Russia.
Comparative Genomics and Phenotypic Investigations Into Antibiotic, Heavy Metal, and Disinfectant Susceptibilities of Salmonella enterica Strains Isolated in Australia.
The study identified several AMR genes and mutations in Salmonella enterica strains, including blaTEM-1, aph(3')-I, aph(6')-ld, dfrA5, tetA, and various arsenic resistance genes. A mutation in gyrA was also found to confer nalidixic acid resistance.
Emergence of Multidrug-Resistant Salmonella enterica Serovar Goldcoast Strains in Taiwan and International Spread of the ST358 Clone.
The study identifies multiple multidrug-resistant Salmonella enterica serovar Goldcoast strains in Taiwan, highlighting the emergence of an ST358 clone carrying various resistance genes, including blaCTX-M-55, mcr-1, and others, contributing to the rapid increase in infections.
Molecular Epidemiology of Multidrug-Resistant Klebsiella pneumoniae Isolates in a Brazilian Tertiary Hospital.
The study identified various AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae isolates, including bla KPC, bla CTX-M, bla TEM, and mutations in ompk35, ompk36, gyrA, and parC. These findings highlight the complex resistance mechanisms contributing to the persistence of MDR-Kp in the hospital setting.
Genomic Sequence Analysis of the Multidrug-Resistance Region of Avian Salmonella enterica serovar Indiana Strain MHYL.
The study identified several AMR genes, including blaTEM, strA, tetA, floR, and aac(6')-Ib-cr, in the multidrug-resistant Salmonella enterica serovar Indiana strain MHYL. These genes were localized in two distinct MDR regions, RR1 and RR2, and were associated with resistance to multiple antibiotics.
Extended-Spectrum Beta-Lactamase-production in Escherichia coli isolated from door handles in Nasarawa State University, Keffi, Nigeria.
The study identified blaTEM and blaSHV genes as the primary extended-spectrum beta-lactamase (ESBL) genes in E. coli isolates from door handles in Nasarawa State University, Keffi, Nigeria. blaCTX-M was not detected in any of the isolates.
Population dynamics of an Escherichia coli ST131 lineage during recurrent urinary tract infection.
The study identified multiple AMR genes and mutations in E. coli ST131 isolates from a patient with recurrent UTIs, including plasmid-borne resistance genes and chromosomal mutations contributing to fluoroquinolone resistance.
Multilocus sequence typing and bla (ESBL) characterization of extended-spectrum beta-lactamase-producing Escherichia coli isolated from healthy humans and swine in Northern Thailand.
The study identified bla CTX-M, bla TEM, and bla SHV as the primary ESBL genes in ESBL-producing E. coli isolates from healthy humans and swine in Northern Thailand. Additionally, several other AMR genes such as sul1, sul2, sul3, aadA22, aph(3')-Ia, strA, strB, aadA2, aadA5, qnrS1, tetA, tetB, tetD, arr2, and mefB were characterized.
Expansion of Salmonella Typhi clonal lineages with ampicillin resistance and reduced ciprofloxacin susceptibility in Eastern China.
The study identified bla TEM-1 as the primary determinant of ampicillin resistance and mutations in gyrA (S83F) and ParC (D87Y) as the main causes of reduced ciprofloxacin susceptibility in Salmonella Typhi isolates from Eastern China.
Characterization of Non-O157 Escherichia coli from Cattle Faecal Samples in the North-West Province of South Africa.
The study identified several antimicrobial resistance genes in non-O157 E. coli isolates from cattle fecal samples, including tetA, tetB, blaTEM-1, aadA1, and catA1, which were associated with resistance to tetracycline, ampicillin, streptomycin, and chloramphenicol.
Whole-genome sequence analysis of multidrug-resistant uropathogenic strains of Escherichia coli from Mexico.
The study identified 29 antibiotic resistance genes in 24 multidrug-resistant uropathogenic E. coli strains from Mexico, including genes conferring resistance to aminoglycosides, fluoroquinolones, beta-lactams, chloramphenicol, sulfonamides, tetracycline, and trimethoprim. Notably, the genes strA, strB, blaTEM-1B, and sul2 were highly prevalent among the strains.
Serotype, antimicrobial susceptibility and genotype profiles of Salmonella isolated from duck farms and a slaughterhouse in Shandong province, China.
The study identified multiple antimicrobial resistance genes, including blaTEM, sul2, aadA7, aac3-Id, aadA5, and dfrA17, in Salmonella isolates from duck farms and a slaughterhouse in Shandong, China. High levels of resistance to various antibiotics were observed, highlighting the need for improved antimicrobial stewardship.
Longitudinal Shedding Patterns and Characterization of Antibiotic Resistant E. coli in Pastured Goats using a Cohort Study.
The study identified tetracycline resistance mediated by tetB, ampicillin resistance via blaTEM, and streptomycin resistance through aadA and strpA/strpB genes in E. coli isolates from pastured goats. Mutations in gyrA conferred resistance to nalidixic acid.
Evolution of Outbreak-Causing Carbapenem-Resistant Klebsiella pneumoniae ST258 at a Tertiary Care Hospital over 8 Years.
The study identifies various AMR genes in ST258 K. pneumoniae isolates, including blaKPC-2, blaKPC-3, aadA2, aadA1, blaTEM-1A, blaSHV-11, blaSHV-12, oqxA, oqxB, fosA, dfrA12, dfrA14, sul1, sul2, catA1, cml, and strAB, which confer resistance to multiple antibiotics.
Dissemination prevention of antibiotic resistant and facultative pathogenic bacteria by ultrafiltration and ozone treatment at an urban wastewater treatment plant.
The study analyzed the effectiveness of ultrafiltration and ozone treatment in reducing antibiotic resistance genes (ARGs) and facultative pathogenic bacteria in wastewater. It identified several ARGs, including sul1, blaTEM, tetM, CTX-M, CTX-M-32, blaOXA-48, blaVIM, CMY-2, vanA, mcr-1, blaNDM, ermB, and intl1, which were found to be prevalent in the wastewater. Both ultrafiltration units showed significant reduction in these ARGs and pathogenic bacteria, whereas ozone treatment was less effective.
Evaluation of in vitro activity of ceftazidime/avibactam and ceftolozane/tazobactam against MDR Pseudomonas aeruginosa isolates from Qatar.
The study evaluated the in vitro activity of ceftazidime/avibactam and ceftolozane/tazobactam against MDR Pseudomonas aeruginosa isolates from Qatar. It identified several beta-lactamase genes, including blaTEM-116, blaVEB-1a, blaCARB-3, blaVIM-2, blaPDC-2, blaPDC-3, blaPDC-5, blaPDC-7, blaOXA-4, blaOXA-10, and blaOXA-50, which contribute to resistance against these antibiotics.
Two cases of multidrug-resistant Neisseria gonorrhoeae related to travel in south-eastern Asia, France, June 2019.
Detection of multidrug resistance and extended-spectrum/plasmid-mediated AmpC beta-lactamase genes in Enterobacteriaceae isolates from diseased cats in Italy.
The study identified various beta-lactamase genes, including CTX-M-1, CTX-M-2, CTX-M-9, CTX-M-79, SHV-12, TEM-92, and CMY-2, which confer resistance to third-generation cephalosporins in Enterobacteriaceae isolates from diseased cats in Italy.
Infectious phage particles packaging antibiotic resistance genes found in meat products and chicken feces.
The study identified various antibiotic resistance genes (ARGs) in phage particles from meat products and chicken feces, highlighting the potential role of phages in the dissemination of resistance.
Modified Antibiotic Adjuvant Ratios Can Slow and Steer the Evolution of Resistance: Co-amoxiclav as a Case Study.
The study identifies blaTEM-1 as a gene conferring resistance to amoxicillin and ampicillin in E. coli, and highlights the role of repY mutations in increasing plasmid copy number and beta-lactamase expression.
Emergence and transmission of New Delhi metallo-beta-lactamase-5-producing Escherichia coli Sequence Type 361 in a Tertiary Hospital in South Korea.
The study reports an outbreak of NDM-5-producing E. coli ST361 in a South Korean hospital, highlighting the multidrug-resistant nature of these isolates and the presence of additional resistance genes such as qepA, blaTEM-1, blaCMY-2, blaCTX-M-15, and aac(6')-Ib-cr.
Antibiotic-Induced, Increased Conjugative Transfer Is Common to Diverse Naturally Occurring ESBL Plasmids in Escherichia coli.
The study shows that antibiotic exposure increases conjugative transfer of various ESBL plasmids in E. coli, highlighting the potential risk of antibiotic use in promoting the spread of antibiotic resistance.
First Detection of Carbapenem-Resistant Escherichia fergusonii Strains Harbouring Beta-Lactamase Genes from Clinical Samples.
Three carbapenem-resistant Escherichia fergusonii isolates (CR11, CR35, and CR49) were identified, harboring CTX-M, TEM, and SHV beta-lactamase genes, leading to resistance against various beta-lactam antibiotics.
High rate of multiresistant Klebsiella pneumoniae from human and animal origin.
The study identified multiple AMR genes, including blaKPC, blaNDM, blaTEM, blaSHV, qnrA, and tolC, in Klebsiella pneumoniae isolates from humans and animals in Henan, China. These genes were associated with resistance to various antibiotics, highlighting the prevalence of multidrug-resistant strains.
Genetic characterization of a novel sequence type of multidrug-resistant Citrobacter freundii strain recovered from wastewater treatment plant.
The study reports the identification of a multidrug-resistant Citrobacter freundii strain R17 carrying 13 antibiotic-resistance genes, including blaCMY-85, aadA2, aac(3)-lld, blaDHA-1, blaTEM-1B, qnrB4, mph(A), catA2, sul1, sul2, tet(D), and dfrA12, which confer resistance to various antibiotic classes.
Comparative genomic analysis and multi-drug resistance differences of Acinetobacter baumannii in Chongqing, China.
The study identified 19 drug resistance genes in 10 multidrug-resistant Acinetobacter baumannii strains, with efflux pump genes being the most prevalent. Key genes included aacA4, which had a 19-bp deletion associated with aminoglycoside resistance, and other genes like TEM-1, OXA-23, and ANT(3'')-IIa.
Shedding of OXA-181 carbapenemase-producing Escherichia coli from companion animals after hospitalisation in Switzerland: an outbreak in 2018.
The study identified the carbapenemase gene blaOXA-181, the quinolone resistance gene qnrS1, the cephalosporinase gene blaCMY-42, and the tetracycline resistance gene tet(A) in carbapenemase-producing Escherichia coli isolates from companion animals in Switzerland. Additionally, chromosomal mutations in GyrA and ParC were associated with high-level fluoroquinolone resistance.
Occurrence of beta-lactamase-Producing Gram-Negative Bacterial Isolates in Water Sources in Cali City, Colombia.
The study identified several beta-lactamase genes, including bla TEM-1, bla CTX-M-9, bla VIM-2, bla IMP-1, and bla AmpC, in Gram-negative bacterial isolates from water sources in Cali, Colombia. These genes conferred resistance to various β-lactam antibiotics, highlighting the presence of antibiotic resistance genes in aquatic environments.
Antibiotic resistance of Escherichia coli isolated from broilers sold at live bird markets in Chattogram, Bangladesh.
The study identified multidrug-resistant Escherichia coli isolates carrying blaTEM, tetA, and Sul2 genes, which confer resistance to ampicillin, tetracycline, and sulfomethoxazole-trimethoprim, respectively.
Antibiotic resistance of Escherichia coli isolated from captive Bengal tigers at Safari parks in Bangladesh.
The study identified blaTEM and sul2 genes in E. coli isolates from Bengal tigers, indicating resistance to ampicillin and sulfamethoxazole-trimethoprim, respectively.
Extended-spectrum beta-lactamase-producing Escherichia coli isolated from healthy Thoroughbred racehorses in Japan.
The study identified bla CTX-M-2 and bla TEM-1 as the primary beta-lactamase genes responsible for extended-spectrum beta-lactamase (ESBL) production in Escherichia coli isolates from healthy Thoroughbred racehorses in Japan.
Prevalence of Resistance to β-Lactam Antibiotics and bla Genes Among Commensal Haemophilus parainfluenzae Isolates from Respiratory Microbiota in Poland.
The study identified several beta-lactamase genes (bla TEM-1, bla OXA, bla DHA, and bla SHV) in Haemophilus parainfluenzae isolates, along with the Lys-526 substitution in the ftsI gene, which contributes to beta-lactam resistance.
Characterization of an Environmental Multidrug-Resistant Acinetobacter seifertii and Comparative Genomic Analysis Reveals Co-occurrence of Antimicrobial Resistance and Metal Tolerance Determinants.
The study characterizes an environmental multidrug-resistant Acinetobacter seifertii isolate (SAb133) and identifies multiple antimicrobial resistance genes, metal tolerance genes, and virulence factors. Key findings include the presence of bla ADC–25, bla TEM, and various efflux pump genes, along with metal tolerance genes and virulence factors.
Characterization of Beta-Lactamases in Bloodstream-Infection Escherichia coli: Dissemination of bla(ADC) (-) (162) and bla(CMY-) (2) Among Bacteria via an IncF Plasmid.
The study characterizes beta-lactamase genes in bloodstream-infection Escherichia coli, identifying blaTEM-1, blaCTX-M-14, blaCTX-M-27, blaCTX-M-55, blaCTX-M-65, blaOXA-30, blaCMY-2, and blaADC-162 as prevalent. These genes were found to be disseminated via IncF plasmids, highlighting their role in multidrug resistance.
Protein Structural Information and Evolutionary Landscape by In Vitro Evolution.
The study characterizes the mutational landscape of TEM-1 beta-lactamase through in vitro evolution, identifying key mutations that influence protein stability and function.
Novel spa and Multi-Locus Sequence Types (MLST) of Staphylococcus Aureus Samples Isolated from Clinical Specimens in Korean.
The study identified novel spa types and MLST types in methicillin-resistant Staphylococcus aureus (MRSA) isolates, along with antibiotic resistance genes such as mecA, TEM, aac(6')-aph(2"), ermA, and tetM, indicating multidrug resistance.
Investigation of urban birds as source of β-lactamase-producing Gram-negative bacteria in Marseille city, France.
The study identifies bla CTX-M-15 and bla TEM-1 genes in β-lactamase-producing Gram-negative bacteria isolated from urban birds in Marseille, highlighting their potential role in the dissemination of antibiotic resistance.
Preliminary survey of extended-spectrum beta-lactamases (ESBLs) in nosocomial uropathogen Klebsiella pneumoniae in north-central Iran.
The study identified the presence of bla TEM, bla CTX-M, and bla SHV genes in ESBL-producing K. pneumoniae isolates, highlighting the high prevalence of these genes in the region.
Molecular characterization of carbapenem-resistant Klebsiella pneumoniae isolates with focus on antimicrobial resistance.
The study identifies blaKPC-2 as the dominant carbapenemase gene in clinical CRKP isolates, along with various ESBLs and other resistance genes such as blaCTX-M, blaTEM, blaSHV, aac(3)-IId, rmtB, QnrS1, oqxA, oqxB, fosA, catA1, catA2, dfrA1, and dfrA17.
First Report of Coexistence of Three Different MDR Plasmids, and That of Occurrence of IMP-Encoding Plasmid in Leclercia adecarboxylata.
The study reports the first identification of three different multidrug-resistant (MDR) plasmids in a single clinical isolate of Leclercia adecarboxylata, including the blaIMP-8 gene encoded on an IMP-encoding plasmid. These plasmids harbor various AMR genes such as blaIMP-8, aacC2, aadA2, mph(A), sul1, qacED1, mer, chrA, dfrA12, tmrB, catA1, catB8, tet(C), blaCTX-M-9, and blaTEM-1.
Metagenomic identification of severe pneumonia pathogens in mechanically-ventilated patients: a feasibility and clinical validity study.
The study identified several AMR genes using Nanopore sequencing, including mecA, blaTEM-4, blaTEM-112, blaTEM-157, blaACT-5, oqxB, tetC, ermA, erm (33), tet38, ant(4′)-lb, tetK, tetQ, sul1, dfrA, acrF, parE, mfd, mphA, aadA5, vgaC, blaACT-5, blaACT-14, mefA, mel, tetX, tetM, isaC, and aadA5, which conferred resistance to various antibiotics such as methicillin, ticarcillin, ceftazidime, erythromycin, clindamycin, tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and levofloxacin.
Metagenomic identification of severe pneumonia pathogens in mechanically-ventilated patients: a feasibility and clinical validity study.
The study identified several AMR genes using Nanopore sequencing, including mecA, blaTEM-4, blaTEM-112, blaTEM-157, blaACT-5, oqxB, tetC, ermA, erm (33), tet38, ant(4′)-lb, tetK, tetQ, sul1, dfrA, acrF, parE, mfd, mphA, aadA5, vgaC, blaACT-5, blaACT-14, mefA, mel, tetX, tetM, isaC, and aadA5, which conferred resistance to various antibiotics such as methicillin, ticarcillin, ceftazidime, erythromycin, clindamycin, tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and levofloxacin.
Metagenomic identification of severe pneumonia pathogens in mechanically-ventilated patients: a feasibility and clinical validity study.
The study identified several AMR genes using Nanopore sequencing, including mecA, blaTEM-4, blaTEM-112, blaTEM-157, blaACT-5, oqxB, tetC, ermA, erm (33), tet38, ant(4′)-lb, tetK, tetQ, sul1, dfrA, acrF, parE, mfd, mphA, aadA5, vgaC, blaACT-5, blaACT-14, mefA, mel, tetX, tetM, isaC, and aadA5, which conferred resistance to various antibiotics such as methicillin, ticarcillin, ceftazidime, erythromycin, clindamycin, tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and levofloxacin.
A Field Study Into Hong Kong's Wet Markets: Raised Questions Into the Hygienic Maintenance of Meat Contact Surfaces and the Dissemination of Microorganisms Associated With Nosocomial Infections.
The study identified antibiotic resistance genes such as tet(M), BlaTEM, and mex(B) in isolates from wooden cutting boards in Hong Kong wet markets, highlighting the potential for cross-contamination and dissemination of clinically relevant resistant organisms.
Occurrence, quantification, pulse types, and antimicrobial susceptibility of Salmonella sp. isolated from chicken meat in the state of Paraná, Brazil.
The study identified bla CTX-M-2 and bla TEM-1 genes in Salmonella isolates from chicken meat in Paraná, Brazil, contributing to resistance against multiple antibiotics including beta-lactams, quinolones, and tetracyclines.
Household cockroaches carry CTX-M-15-, OXA-48- and NDM-1-producing enterobacteria, and share beta-lactam resistance determinants with humans.
The study identified CTX-M-15, OXA-48, and NDM-1 beta-lactamase genes in enterobacteria from household cockroaches and human fecal samples, highlighting the potential for these pests to serve as reservoirs of antibiotic resistance genes.
Household cockroaches carry CTX-M-15-, OXA-48- and NDM-1-producing enterobacteria, and share beta-lactam resistance determinants with humans.
The study identified CTX-M-15, OXA-48, and NDM-1 beta-lactamase genes in enterobacteria from household cockroaches and human fecal samples, highlighting the potential for these pests to serve as reservoirs of antibiotic resistance genes.
Household cockroaches carry CTX-M-15-, OXA-48- and NDM-1-producing enterobacteria, and share beta-lactam resistance determinants with humans.
The study identified CTX-M-15, OXA-48, and NDM-1 beta-lactamase genes in enterobacteria from household cockroaches and human fecal samples, highlighting the potential for these pests to serve as reservoirs of antibiotic resistance genes.
Molecular Detection Of Multidrug-Resistant Salmonella Isolated From Livestock Production Systems In South Africa.
The study identified multiple multidrug-resistant Salmonella isolates from livestock in South Africa, highlighting the presence of resistance genes such as blaTEM-1, blaCMY-2, tetA, tetC, sul2, and dfrA7.
First Reported Nosocomial Outbreak Of NDM-5-Producing Klebsiella pneumoniae In A Neonatal Unit In China.
The study describes the first reported nosocomial outbreak of NDM-5-producing Klebsiella pneumoniae in a neonatal unit in China, highlighting the presence of bla NDM-5, bla SHV-11, and bla TEM-1 genes conferring resistance to multiple beta-lactam antibiotics.
Molecular detection and antibiotic resistance pattern of extended-spectrum beta-lactamase producing Escherichia coli in a Tertiary Hospital in Enugu, Nigeria.
The study identified bla CTX-M, bla TEM, and bla SHV genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) production in E. coli isolates from a Nigerian hospital. These genes were detected in 35% of the E. coli isolates, with bla CTX-M being the most prevalent.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Genotypic validation of extended-spectrum beta-lactamase and virulence factors in multidrug resistance Klebsiella pneumoniae in an Indian hospital.
The study identified blaTEM, blaSHV, and blaCTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) production in multidrug-resistant Klebsiella pneumoniae isolates. Additionally, virulence factors such as fimH-1, mrkD, entB, irp-1, K1, and K2 were found to be prevalent among the isolates.
The Occurrence and Characterization of Extended-Spectrum-Beta-Lactamase-Producing Escherichia coli Isolated from Clinical Diagnostic Specimens of Equine Origin.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including a novel TEM-1-type gene, bla TEM-233, in Escherichia coli isolates from equine clinical specimens. It also detected bla SHV-12, bla CTX-M-1, bla OXA-1, and bla IMP-1, highlighting the presence of multidrug-resistant E. coli in equine populations.
Decreasing prevalence of contamination with extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in retail chicken meat in the Netherlands.
The study identified several ESBL genes, including bla CTX-M-1, bla SHV-12, and others, in ESBL-E isolates from retail chicken meat in the Netherlands. The prevalence of ESBL-E decreased over time, and there were variations in prevalence among different supermarket chains and farming methods.
Decreasing prevalence of contamination with extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in retail chicken meat in the Netherlands.
The study identified several ESBL genes, including bla CTX-M-1, bla SHV-12, and others, in ESBL-E isolates from retail chicken meat in the Netherlands. The prevalence of ESBL-E decreased over time, and there were variations in prevalence among different supermarket chains and farming methods.
Decreasing prevalence of contamination with extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in retail chicken meat in the Netherlands.
The study identified several ESBL genes, including bla CTX-M-1, bla SHV-12, and others, in ESBL-E isolates from retail chicken meat in the Netherlands. The prevalence of ESBL-E decreased over time, and there were variations in prevalence among different supermarket chains and farming methods.
Antimicrobial Resistance Factors of Extended-Spectrum Beta-Lactamases Producing Escherichia coli and Klebsiella pneumoniae Isolated from Cattle Farms and Raw Beef in North-West Province, South Africa.
The study identified ESBL genes including blaTEM, blaSHV, blaCTX-M, and blaOXA in E. coli and K. pneumoniae isolates from cattle feces and raw beef, highlighting the presence of multidrug-resistant strains in the food chain.
Characterization and Bio-Typing of Multidrug Resistance Plasmids From Uropathogenic Escherichia coli Isolated From Clinical Setting.
The study characterized multidrug-resistant plasmids in uropathogenic E. coli, identifying genes such as blaTEM, blaCTX-M, blaOXA, aac(6')-Ib-cr, oqxAB, and qnrB, which confer resistance to various antibiotics. These plasmids were found to be transmissible via conjugation, highlighting the role of IncF and IncI conjugation systems in the spread of resistance.
Molecular-diversity, Prevalence and Antibiotic Susceptibility of Pathogenic Klebsiella Pneumoniae under Saudi Condition.
The study identified the SHV-9, CTX-M-15, TEM-1, IMP-4, KPC2, and KPC3 genes as prevalent in Klebsiella pneumoniae isolates in Saudi Arabia, contributing to resistance against multiple antibiotics.
Role of Horizontal Gene Transfer in the Development of Multidrug Resistance in Haemophilus influenzae.
The study identifies several AMR genes and mutations in Haemophilus influenzae, highlighting the role of horizontal gene transfer in the development of multidrug resistance. Key findings include the identification of blaTEM-1, catA2-like, tet(B), and catP genes, as well as mutations in the ftsI gene that confer resistance to extended-spectrum cephalosporins.
Prevalence and Molecular Characteristics of Extended-Spectrum and AmpC beta-lactamase Producing Escherichia coli in Grazing Beef Cattle.
The study identified various beta-lactamase genes, including CTX-M-1, CTX-M-15, CTX-M-27, CTX-M-32, CTX-M-55, TEM-1A, TEM-1B, and CMY-2, in ESBL/AmpC producing E. coli isolates from beef cattle farms. These genes conferred resistance to multiple antibiotics such as ceftiofur, cefotaxime, ampicillin, cephalothin, and chloramphenicol.
Prevalence and Molecular Characteristics of Extended-Spectrum and AmpC beta-lactamase Producing Escherichia coli in Grazing Beef Cattle.
The study identified various beta-lactamase genes, including CTX-M-1, CTX-M-15, CTX-M-27, CTX-M-32, CTX-M-55, TEM-1A, TEM-1B, and CMY-2, in ESBL/AmpC producing E. coli isolates from beef cattle farms. These genes conferred resistance to multiple antibiotics such as ceftiofur, cefotaxime, ampicillin, cephalothin, and chloramphenicol.
Genomic surveillance detects Salmonella enterica serovar Paratyphi A harbouring blaCTX-M-15 from a traveller returning from Bangladesh.
Colistin-resistant Escherichia coli carrying mcr-1 in food, water, hand rinse, and healthy human gut in Bangladesh.
The study identified colistin-resistant Escherichia coli carrying the mcr-1 gene in various environmental and human samples in Bangladesh, highlighting the spread of colistin resistance.
Phenotypic and molecular characterization of antimicrobial resistant Escherichia coli from urinary tract infections in Port-Harcourt, Nigeria.
The study identified multiple antimicrobial resistance genes in E. coli isolates from urinary tract infections in Port-Harcourt, Nigeria, including blaTEM, blaCTX-M-15, blaSHV, blaOXA-1, blaCMY-2, qnrD, qnrS, aac(6')-Ib, and aacC2. These genes were associated with resistance to various antibiotics, highlighting the complexity of multidrug resistance in these isolates.
Genomic evolution of Neisseria gonorrhoeae since the preantibiotic era (1928-2013): antimicrobial use/misuse selects for resistance and drives evolution.
The study characterizes various AMR genes and mutations in Neisseria gonorrhoeae, highlighting the emergence of resistance to multiple antimicrobials over time, including penicillin, fluoroquinolones, macrolides, tetracyclines, and sulfonamides. Key findings include the identification of penB, mtrR, penA, gyrA, parC, folP, rpsJ, tetM, and blaTEM as critical AMR genes, along with mutations in penB, mtrR, gyrA, parC, penA, and ponA that contribute to resistance mechanisms.
Molecular characterization of avian pathogenic Escherichia coli from broiler chickens with colibacillosis.
The study identified several AMR genes in APEC isolates, including beta-lactamases (bla TEM-1, bla CTX-M-1, bla CTX-M-15), aminoglycoside-modifying enzymes (aac(3)-II), plasmid-mediated quinolone resistance genes (qnrA, qnrS), tetracycline resistance genes (tetA), sulfonamide resistance genes (sul2), and chloramphenicol resistance genes (catA1, cmlA).
Prevalence and characteristics of multidrug-resistant mcr-1-positive Escherichia coli isolates from broiler chickens in Tai'an, China.
The study identified mcr-1 as the primary cause of colistin resistance in E. coli isolates from broiler chickens in Tai'an, China, with high prevalence of multidrug resistance involving genes like bla TEM, bla CTX-M, aphA3, tetA, tetB, tetC, sul1, and sul2.
ESKAPE Bacteria and Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolated from Wastewater and Process Water from German Poultry Slaughterhouses.
The study identified several beta-lactamase genes (bla TEM, bla CTX-M, bla SHV) and the mcr-1 gene conferring resistance to colistin in ESKAPE bacteria and ESBL-producing E. coli isolated from wastewater and process water in German poultry slaughterhouses.
Research Note: Longitudinal monitoring of chicken houses in a commercial layer farm for antimicrobial resistance in Escherichia coli with special reference to plasmid-mediated quinolone resistance.
The study identified qnrS1, qnrS2, and qnrS13 genes as plasmid-mediated quinolone resistance genes in E. coli isolates from a commercial layer farm. Additionally, blaTEM, aadA, tetA, and dfrA1 genes were found to confer resistance to ampicillin, dihydrostreptomycin, oxytetracycline, and trimethoprim, respectively.
Complete Nucleotide Sequence of Plasmids of Two Escherichia coli Strains Carrying bla (NDM-) (5) and bla (NDM) (-) (5) and bla (OXA) (-) (181) From the Same Patient.
The study characterizes two carbapenemase-producing E. coli strains carrying blaNDM-5 and blaOXA-181, along with various other resistance genes such as qnrS1, blaCTX-M-15, aac(6')-lb-cr, catB3, sul1, dfrA17, qacEΔ1, aadA5, rmtB, ermB, mphA, tetB, catA1, dfrA14, dfrA12, blaTEM-1B, and blaCMY-42.
Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae.
The study identifies various beta-lactamase genes, including bla KPC-2, bla TEM-1B, bla SHV-182, bla OXA-1, bla CTX-M-15, bla ACT-7, bla CTX-M-8, and bla OXA-9, which contribute to β-lactam resistance in carbapenem-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates.
Whole Genome Sequencing of Escherichia coli From Store-Bought Produce.
The study identified various antimicrobial resistance genes in tetracycline-resistant E. coli strains from store-bought produce, highlighting the prevalence of multidrug resistance and the role of plasmids and integrons in the spread of resistance.
Should we leave the paper currency? A microbiological examination.
The study identified various antimicrobial resistance genes including mecA, vanA, blaTEM, blaSHV, blaCTX-M-1, blaCTX-M-2, blaKPC, and blaOXA-48 in bacteria isolated from Turkish banknotes, highlighting the potential role of paper currency in spreading pathogens and antimicrobial resistance.
Genomic Investigation Reveals Contaminated Detergent as the Source of an Extended-Spectrum-β-Lactamase-Producing Klebsiella michiganensis Outbreak in a Neonatal Unit.
Population structure and antimicrobial resistance patterns of Salmonella Typhi isolates in urban Dhaka, Bangladesh from 2004 to 2016.
Carbapenem-Resistant Enterobacter hormaechei ST1103 with IMP-26 Carbapenemase and ESBL Gene bla (SHV-178).
The study identifies a multidrug-resistant Enterobacter hormaechei strain L51 carrying the bla IMP-26 carbapenemase gene and bla SHV-178 ESBL gene, along with other resistance genes on a conjugative IncHI2/2A plasmid.
Resistome in Lake Bolonha, Brazilian Amazon: Identification of Genes Related to Resistance to Broad-Spectrum Antibiotics.
The study identified several AMR genes in Lake Bolonha, including bla CTX-M, bla SHV, bla TEM, bla VIM, bla IMP, intl1, and intl2, which confer resistance to beta-lactams and other antibiotics. These genes were found in various bacterial isolates, highlighting the presence of multidrug-resistant bacteria in the lake.
Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.
The study identifies known and novel antimicrobial resistance genes using a machine learning approach on pan-genomes of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Key findings include the detection of resistance genes such as gyrA, parC, ermC, lmrS, aac(6')-aph(2"), dfrG, tetK, and various beta-lactamases.
A survey of extended-spectrum beta-lactamase-producing Enterobacteriaceae in urban wetlands in southwestern Nigeria as a step towards generating prevalence maps of antimicrobial resistance.
The study identified the presence of extended-spectrum beta-lactamase genes bla CTX-M-15, bla TEM-1B, bla OXA-1, and ampC in Enterobacteriaceae isolates from urban wetlands in Nigeria, highlighting the significant contamination of these environments with clinically relevant antimicrobial resistance genes.
Oral colonisation by antimicrobial-resistant Gram-negative bacteria among long-term care facility residents: prevalence, risk factors, and molecular epidemiology.
The study identified several AMR genes in Gram-negative bacteria isolated from LTCF residents, including bla CTX-M-27, bla CTX-M-14, bla TEM-1B, bla IMP-1, and others, which confer resistance to various antibiotics such as β-lactams, aminoglycosides, and fluoroquinolones.
Two New SGI1-LK Variants Found in Proteus mirabilis and Evolution of the SGI1-HKL Group of Salmonella Genomic Islands.
The study identifies two new SGI1-LK variants, SGI1-LK1 and SGI1-LK2, in Proteus mirabilis isolates, highlighting the evolutionary dynamics of the SGI1-HKL group of Salmonella genomic islands.
Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes.
The study identifies negative epistasis between the tetracycline efflux pump TetA and mutations in the nuo genes, which affects aminoglycoside resistance. It also characterizes the roles of various antibiotic resistance genes (ARGs) such as blaTEM-219, floR, qnrS1, and tetA in resistance to different antibiotics.
Antibiotic resistance and virulence patterns of pathogenic Escherichia coli strains associated with acute gastroenteritis among children in Qatar.
The study identified bla CTX-M-G1, bla CTX-M-3, bla CTX-M-15, bla TEM, and bla SHV as the main genes responsible for extended-spectrum beta-lactamase (ESBL) production in EPEC and EAEC strains isolated from children with acute gastroenteritis in Qatar.
Genome-Based Analysis of Extended-Spectrum beta-lactamase-Producing Escherichia coli in the Aquatic Environment and Nile Perch (Lates niloticus) of Lake Victoria, Tanzania.
The study identified multiple AMR genes in ESBL-producing E. coli from Nile perch and water samples in Lake Victoria, including bla CTX-M-15, bla TEM-1B, aadA2, aac(3)-IId, sul1, sul2, dfrA12, qepA4, tetB, tetD, mphA, mdfA, catA1, strA, strB, nfaE, iss, vat, and lpfA.
Prevalence and Molecular Characteristics of Avian-Origin mcr-1-Harboring Escherichia coli in Shandong Province, China.
The study identified the mcr-1 gene, blaTEM, blaCTX-M, aac(6)-Ib-cr, and qnrA as the primary AMR genes in avian-origin E. coli isolates in Shandong Province, China.
Molecular Detection of Multidrug Resistant Salmonella Species Isolated from Broiler Farm in Bangladesh.
The study identified multidrug-resistant Salmonella enterica serovar Typhimurium isolates from broiler farms in Bangladesh, carrying resistance genes tetA, floR, blaTEM-1, aadA1, and class 1 integron gene intl1.
Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium.
The study identified 24 different antimicrobial-resistance determinants in Gallibacterium anatis isolates from calves with unresponsive bronchopneumonia, including novel resistance genes such as aadA23, blaCARB-8, tet(Y), and qnrD1.
Environmental remodeling of human gut microbiota and antibiotic resistome in livestock farms.
The study identifies several antibiotic resistance genes, including bla CTX-M, fosA3, bla TEM, qnrS, and tet(X), which were enriched in the gut resistome of students exposed to swine farm environments. These genes conferred resistance to various antibiotics such as cephalosporins, fosfomycin, penicillins, fluoroquinolones, and tetracyclines.
Phylogenetic Grouping of Human Ocular Escherichia coli Based on Whole-Genome Sequence Analysis.
The study identified 22 AMR genes in 10 ocular E. coli isolates, including bla CTX-M-15, dfrA17, aadA2, aadA5, bla OXA-1, bla NDM-5, dfrA12, bla TEM-1 B, mdfA, emrB, mphA, sul1, sul2, and aac(6')-1b-cr. Additionally, chromosomal mutations in parE, gyrA, and parC were found to confer resistance to fluoroquinolones.
Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report.
Putative Protein Biomarkers of Escherichia coli Antibiotic Multiresistance Identified by MALDI Mass Spectrometry.
The study identifies several AMR genes in E. coli isolates, including tet(A), tet(B), blaCTX-M, blaTEM, blaSHV, sul1, sul2, sul3, cmlA, aac(3)-II, aac(3)-IV, aadA, and strA-strB, which confer resistance to tetracycline, ampicillin, cefoxitin, trimethoprim-sulfamethoxazole, chloramphenicol, gentamicin, and streptomycin.
Metadata Analysis of mcr-1-Bearing Plasmids Inspired by the Sequencing Evidence for Horizontal Transfer of Antibiotic Resistance Genes Between Polluted River and Wild Birds.
The study identifies the mcr-1 gene as a key factor in colistin resistance in E. coli strains isolated from polluted rivers and wild birds. It also characterizes several other AMR genes including aadA1, aadA2, aph(3′)-Ia, aph(3″)-Ib, aph(4)-Ia, aph(6)-Id, tet(B), tet(D), tet(A), bla CTX–M–14, bla TEM–1, qnrS2, oqxA, oqxB, cmlA1, floR, vgaC, sul1, sul2, sul3, dfrA12, and glpT (E448K).
Antibiotic-resistant Escherichia coli isolated from urban rodents in Hanoi, Vietnam.
The study identified multiple antimicrobial resistance genes in Escherichia coli isolated from urban rodents in Hanoi, Vietnam, including bla TEM, tet(A), sul1, sul2, sul3, and mcr-1, highlighting the potential of rodents as reservoirs of multidrug-resistant and colistin-resistant E. coli.
Antimicrobial Resistance in Farm Animals in Brazil: An Update Overview.
The review highlights the prevalence of antimicrobial resistance in farm animals in Brazil, particularly in Salmonella, E. coli, and Campylobacter. Key resistance genes identified include blaCTX-M-2 and blaTEM-1, which confer resistance to beta-lactam antibiotics.
Antimicrobial Resistance in Farm Animals in Brazil: An Update Overview.
The review highlights the prevalence of antimicrobial resistance in farm animals in Brazil, particularly in Salmonella, E. coli, and Campylobacter. Key resistance genes identified include blaCTX-M-2 and blaTEM-1, which confer resistance to beta-lactam antibiotics.
International clones of extended-spectrum beta-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil.
The study identified various AMR genes in CTX-M-producing E. coli isolates from peri-urban wild animals in Brazil, including bla CTX-M-55, bla CTX-M-2, bla CTX-M-15, bla CTX-M-14, and others, indicating the presence of multidrug-resistant bacteria in wildlife.
Prevalence, Antimicrobial Resistance, Virulence Genes and Genetic Diversity of Salmonella Isolated from Retail Duck Meat in Southern China.
The study identified multiple antimicrobial resistance genes in Salmonella isolates from retail duck meat in Southern China, including blaTEM, blaCTX-M, strA, aadA1, qnrS, aac(6')-Ib, qnrB, and floR, which confer resistance to various antibiotics such as ampicillin, cefotaxime, streptomycin, ciprofloxacin, ofloxacin, and florfenicol.
Whole Genome Sequencing and Characteristics of mcr-1-Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B.
The study identified the mcr-1.1 gene in five porcine E. coli isolates, which confers resistance to colistin. The gene was found on various plasmids, including IncF, IncX4, and IncHI2, highlighting the role of mobile genetic elements in the spread of colistin resistance.
Whole Genome Sequencing and Characteristics of mcr-1-Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B.
The study identified the mcr-1.1 gene in five porcine E. coli isolates, which confers resistance to colistin. The gene was found on various plasmids, including IncF, IncX4, and IncHI2, highlighting the role of mobile genetic elements in the spread of colistin resistance.
Whole Genome Sequencing and Characteristics of mcr-1-Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B.
The study identified the mcr-1.1 gene in five porcine E. coli isolates, which confers resistance to colistin. The gene was found on various plasmids, including IncF, IncX4, and IncHI2, highlighting the role of mobile genetic elements in the spread of colistin resistance.
Whole Genome Sequencing and Characteristics of mcr-1-Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B.
The study identified the mcr-1.1 gene in five porcine E. coli isolates, which confers resistance to colistin. The gene was found on various plasmids, including IncF, IncX4, and IncHI2, highlighting the role of mobile genetic elements in the spread of colistin resistance.
Whole Genome Sequencing and Characteristics of mcr-1-Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B.
The study identified the mcr-1.1 gene in five porcine E. coli isolates, which confers resistance to colistin. The gene was found on various plasmids, including IncF, IncX4, and IncHI2, highlighting the role of mobile genetic elements in the spread of colistin resistance.
Whole Genome Sequencing and Characteristics of mcr-1-Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B.
The study identified the mcr-1.1 gene in five porcine E. coli isolates, which confers resistance to colistin. The gene was found on various plasmids, including IncF, IncX4, and IncHI2, highlighting the role of mobile genetic elements in the spread of colistin resistance.
Molecular Epidemiology and Antimicrobial Resistance of Haemophilus influenzae in Adult Patients in Shanghai, China.
The study identified blaTEM-1 as a beta-lactamase gene and various mutations in the ftsI gene (encoding PBP3) as key contributors to ampicillin resistance in Haemophilus influenzae isolates from adult patients in Shanghai.
Resident microbial communities inhibit growth and antibiotic-resistance evolution of Escherichia coli in human gut microbiome samples.
The study found that resident microbial communities in the human gut microbiome inhibited the growth and antibiotic-resistance evolution of a focal strain of Escherichia coli. Mutations in genes such as ompR, ftsI, relA, rpoC, rpoD, opgB, and yaiO were associated with ampicillin resistance in the focal strain.
Antimicrobial resistance of Escherichia coli isolated from retail foods in northern Xinjiang, China.
The study identified various antimicrobial resistance genes in Escherichia coli isolates from retail foods in northern Xinjiang, China, including tetA, tetB, blaOXA, blaTEM, floR, sul1, sul2, aadAla, aadB, strA, and strB. These genes conferred resistance to tetracycline, beta-lactams, chloramphenicol, sulfonamides, and streptomycin.
Occurrence, Phenotypic and Molecular Characterization of Extended-Spectrum- and AmpC- β-Lactamase Producing Enterobacteriaceae Isolated From Selected Commercial Spinach Supply Chains in South Africa.
The study identified several beta-lactamase genes, including bla CTX-M, bla TEM, bla SHV, bla OXA, and bla CIT, which confer resistance to various beta-lactam antibiotics in ESBL/AmpC-producing Enterobacteriaceae isolated from spinach supply chains in South Africa.
An NDM-1-Producing Acinetobacter towneri Isolate from Hospital Sewage in China.
Functional and structural map of pLST1000: A multiresistance plasmid widely distributed in Enterobacteriaceae.
The study characterizes the multiresistance plasmid pLST1000, identifying several AMR genes including aadB, aadA, bla-TEM, bla-OXA2, sul, and mer, which confer resistance to gentamicin, streptomycin, ampicillin, sulfonamide, and mercury, respectively.
Clinically Relevant Extended-Spectrum beta-lactamase-Producing Escherichia coli Isolates From Food Animals in South Korea.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-14, bla CTX-M-55, bla CTX-M-65, and bla TEM-1, in cefotaxime-resistant Escherichia coli isolates from food animals in South Korea. These genes conferred resistance to various β-lactam antibiotics.
Antimicrobial Resistance Profiles of Adherent Invasive Escherichia coli Show Increased Resistance to β-Lactams.
Gram-negative bacteria carrying β-lactamase encoding genes in hospital and urban wastewater in Brazil.
The study identified β-lactamase encoding genes, including bla KPC, bla TEM, bla SHV, and bla CTX-M, in Gram-negative bacteria from hospital and urban wastewater in Brazil, highlighting the presence of multidrug-resistant strains.
Non-antibiotic pharmaceuticals enhance the transmission of exogenous antibiotic resistance genes through bacterial transformation.
Non-antibiotic pharmaceuticals enhance the transformation frequency of exogenous antibiotic resistance genes (ARGs) in Acinetobacter baylyi, particularly those encoding resistance to ampicillin (blaTEM-1) and tetracycline (tetA).
Exploring the Potential of CRISPR-Cas9 Under Challenging Conditions: Facing High-Copy Plasmids and Counteracting Beta-Lactam Resistance in Clinical Strains of Enterobacteriaceae.
The study demonstrates that CRISPR-Cas9 can target and disrupt the blaTEM-1 gene, leading to re-sensitization of clinical isolates of Enterobacteriaceae to multiple beta-lactam antibiotics.
Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India.
The study identified several AMR genes and mutations in Salmonella Typhi isolates, including beta-lactamases (blaTEM-1B, blaTEM-116), chloramphenicol resistance gene (catA1), trimethoprim resistance genes (dfrA7, dfrA15), sulfamethoxazole resistance genes (sul1, sul2), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE genes.
Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India.
The study identified several AMR genes and mutations in Salmonella Typhi isolates, including beta-lactamases (blaTEM-1B, blaTEM-116), chloramphenicol resistance gene (catA1), trimethoprim resistance genes (dfrA7, dfrA15), sulfamethoxazole resistance genes (sul1, sul2), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE genes.
Antimicrobial Resistance Traits of Escherichia coli Isolated from Dairy Manure and Freshwater Ecosystems Are Similar to One Another but Differ from Associated Clinical Isolates.
The study identified blaTEM-1 as the most common ESBL gene in E. coli isolates from dairy manure, freshwater ecosystems, and clinical sources, highlighting its prevalence and potential for horizontal gene transfer.
Emergence of β-lactamase- and carbapenemase- producing Enterobacteriaceae at integrated fish farms.
The study identified several β-lactamase and carbapenemase genes, including bla KPC, bla OXA-48, bla NDM, bla CTX-M-15, bla SHV, bla OXA-1, bla TEM, and bla PER-1, which confer resistance to cephalosporins and carbapenems in Enterobacteriaceae isolated from fish, water, and workers at integrated agriculture-aquaculture systems in Egypt.
Metagenomic Diagnosis for a Culture-Negative Sample From a Patient With Severe Pneumonia by Nanopore and Next-Generation Sequencing.
The study identified several AMR genes in a culture-negative sample from a patient with severe pneumonia, including bla SHV-12, bla KPC-2, bla TEM-1, bla CTX-M-65, aac(3)-IIa, aadA1, dfrA1, sul1, aph(3')-Ia, catA1, fosA, acrA, and rmtB, which confer resistance to various antibiotics.
Cointegration as a mechanism for the evolution of a KPC-producing multidrug resistance plasmid in Proteus mirabilis.
The study characterizes two carbapenemase-producing plasmids, pT18 and pT211, from Proteus mirabilis, highlighting the role of cointegrate plasmids in the dissemination of antibiotic resistance genes. The plasmids carry various resistance genes, including blaKPC-2, blaCTX-M-65, blaTEM-1B, rmtB, and fosA3, contributing to multidrug resistance.
Prevalence of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Causing Bloodstream Infections in Cancer Patients from Southwest of Iran.
The study identified bla CTX-M and bla TEM genes as the most prevalent ESBL genes in Enterobacteriaceae isolates causing bloodstream infections in cancer patients in southwest Iran.
In vitro conjugation kinetics of AmpC, broad spectrum and extended-spectrum beta-lactamase-producing Escherichia coli donors and various Enterobacteriaceae recipients.
The study characterizes several beta-lactamase genes (blaCTX-M-1, blaCTX-M-15, blaSHV-12, blaTEM-52, blaTEM-1, and blaCMY-2) that confer resistance to ceftazidime and cefotaxime in Escherichia coli donors, highlighting their role in conjugation and horizontal gene transfer among Enterobacteriaceae.
In vitro conjugation kinetics of AmpC, broad spectrum and extended-spectrum beta-lactamase-producing Escherichia coli donors and various Enterobacteriaceae recipients.
The study characterizes several beta-lactamase genes (blaCTX-M-1, blaCTX-M-15, blaSHV-12, blaTEM-52, blaTEM-1, and blaCMY-2) that confer resistance to ceftazidime and cefotaxime in Escherichia coli donors, highlighting their role in conjugation and horizontal gene transfer among Enterobacteriaceae.
Prevalence and distribution of antimicrobial resistance determinants of Escherichia coli isolates obtained from meat in South Africa.
The study identified several AMR genes in E. coli isolates from meat in South Africa, including aadA, strA, aph(3)-Ia, aph(3)-IIa, aac(3)-IIa, blaTEM, blaZ, ampC, cat1, cat2, cmlA1, sul1, sul2, tetA, tetB, tetC, tetD, and tetM, which confer resistance to various antibiotics such as streptomycin, kanamycin, neomycin, gentamicin, amoxicillin, ampicillin, chloramphenicol, cotrimoxazole, and tetracycline.
In Vitro Activity of Essential Oils Against Planktonic and Biofilm Cells of Extended-Spectrum β-Lactamase (ESBL)/Carbapenamase-Producing Gram-Negative Bacteria Involved in Human Nosocomial Infections.
The study identified several beta-lactamase genes, including blaCTX-M-15, blaTEM-52, blaCTX-M-1, blaKPC-2, blaVIM-1, and blaVIM-2, which confer resistance to various beta-lactam antibiotics in ESBL and carbapenemase-producing Gram-negative bacteria.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Antimicrobial Resistance Pattern of Escherichia coli Isolated from Frozen Chicken Meat in Bangladesh.
The study identified bla TEM, bla SHV, and bla CTX-M-2 genes in ESBL-producing E. coli isolates from frozen chicken meat in Bangladesh, highlighting the presence of multidrug-resistant and extensively drug-resistant strains.
Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines.
The study identifies various carbapenemase genes such as blaNDM-1, blaNDM-7, blaCTX-M-15, and blaOXA-181, along with other AMR genes like rmtC, sul1, aac(6')-Ib-cr, mph(A), qnrB1, and others, which contribute to resistance against multiple antibiotics in Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa in the Philippines.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
The study identifies multiple AMR genes and mutations in MDR E. coli strains from captive wild animals, highlighting the presence of CTX-M-8 and CTX-M-65 beta-lactamases, along with various other resistance mechanisms such as aminoglycoside, tetracycline, and fluoroquinolone resistance genes, as well as mutations in quinolone resistance-determining regions.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
The study identifies multiple AMR genes and mutations in MDR E. coli strains from captive wild animals, highlighting the presence of CTX-M-8 and CTX-M-65 beta-lactamases, along with various other resistance mechanisms such as aminoglycoside, tetracycline, and fluoroquinolone resistance genes, as well as mutations in quinolone resistance-determining regions.
Association of intestinal colonization of ESBL-producing Enterobacteriaceae in poultry slaughterhouse workers with occupational exposure-A German pilot study.
The study identified the presence of ESBL-producing E. coli in poultry slaughterhouse workers, with the detection of bla CTX-M-15, bla SHV-12, and bla TEM-135 genes.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
The study identified multiple AMR genes and mutations in E. coli isolates from diseased chickens in the Czech Republic, highlighting the presence of multidrug-resistant strains with resistance to β-lactams, quinolones, sulfonamides, and tetracyclines.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
The study identified multiple AMR genes and mutations in E. coli isolates from diseased chickens in the Czech Republic, highlighting the presence of multidrug-resistant strains with resistance to β-lactams, quinolones, sulfonamides, and tetracyclines.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
The study identified multiple AMR genes and mutations in E. coli isolates from diseased chickens in the Czech Republic, highlighting the presence of multidrug-resistant strains with resistance to β-lactams, quinolones, sulfonamides, and tetracyclines.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
The study identified multiple AMR genes and mutations in E. coli isolates from diseased chickens in the Czech Republic, highlighting the presence of multidrug-resistant strains with resistance to β-lactams, quinolones, sulfonamides, and tetracyclines.
Characterization of Extended-Spectrum beta-lactamase-Producing Uropathogenic Escherichia coli Among Iranian Kidney Transplant Patients.
The study identified bla CTX-M, bla TEM, and bla SHV genes as the primary extended-spectrum beta-lactamase (ESBL) genes in uropathogenic Escherichia coli (UPEC) isolates from kidney transplant patients (KTPs) and controls. bla CTX-M was the most prevalent, followed by bla TEM, and bla SHV was less common.
Characterizing Antimicrobial Resistant Escherichia coli and Associated Risk Factors in a Cross-Sectional Study of Pig Farms in Great Britain.
The study identified tetracycline resistance gene tet(A), beta-lactamase bla TEM-1b, streptomycin resistance genes strAB, and plasmid-mediated quinolone resistance gene qnrS1 in E. coli isolates from pig farms in Great Britain. Chromosomal mutations in gyrA and parC were also linked to fluoroquinolone resistance.
Plasmid Replicon Typing of Antibiotic-Resistant Escherichia coli From Clams and Marine Sediments.
The study identified various antibiotic resistance genes in E. coli isolates from clams and marine sediments, including blaTEM, blaSHV, blaCTX-M, tet(A), dfrA1, aadA, strA, strB, and ant(3"). These genes were associated with resistance to beta-lactams, tetracycline, trimethoprim/sulfamethoxazole, and streptomycin.
Genes Encoding the Virulence and the Antimicrobial Resistance in Enterotoxigenic and Shiga-Toxigenic E. coli Isolated from Diarrheic Calves.
The study identified aadB, sul1, and bla-TEM as the primary antimicrobial resistance genes in E. coli isolates from diarrheic calves, with aadB being the most prevalent.
Genomic characterization of multidrug-resistant ESBL-producing Escherichia coli ST58 causing fatal colibacillosis in critically endangered Brazilian merganser (Mergus octosetaceus).
The study identifies a multidrug-resistant ESBL-producing E. coli ST58 strain (PMPU) isolated from a critically endangered Brazilian merganser, carrying genes conferring resistance to various antibiotics, heavy metals, and disinfectants, along with fluoroquinolone resistance mutations.
Genomic Characterisation of a Multiple Drug Resistant IncHI2 ST4 Plasmid in Escherichia coli ST744 in Australia.
The study describes the first complete sequence of a multiple drug-resistant IncHI2 ST4 plasmid, pTZ41_1P, from a commensal E. coli in Australia. The plasmid carries genes conferring resistance to heavy metals, beta-lactams, aminoglycosides, and sulfonamides.
Co-Occurrence of the bla (KPC-2) and Mcr-3.3 Gene in Aeromonas caviae SCAc2001 Isolated from Patients with Diarrheal Disease.
The study identifies multiple antimicrobial resistance genes in Aeromonas caviae SCAc2001, including blaKPC, mcr-3.3, and others, highlighting the potential public health risks posed by this strain.
Molecular identification and antibiotic resistance profiling of Salmonella species isolated from chickens in eastern Turkey.
The study identified the presence of antibiotic resistance genes sul1, tetA, and blaTEM in Salmonella isolates from chickens in eastern Turkey, with sul1 being the most frequently detected gene.
Treatment Failure in Urinary Tract Infections: A Warning Witness for Virulent Multi-Drug Resistant ESBL- Producing Escherichia coli.
The study identified ESBL-producing E. coli isolates with high levels of multidrug resistance, primarily carrying bla CTX-M, bla SHV, and bla TEM genes, leading to resistance against multiple antibiotics including cephalosporins, fluoroquinolones, and others.
Structural Genomics of repA, repB 1-Carrying IncFIB Family pA1705-qnrS, P911021-tetA, and P1642-tetA, Multidrug-Resistant Plasmids from Klebsiella pneumoniae.
The study characterizes multidrug-resistant plasmids pA1705-qnrS, p911021-tetA, and p1642-tetA from Klebsiella pneumoniae, identifying several AMR genes including beta-lactamases (bla CTX-M-14, bla TEM-1, bla OXA-1, bla SHV-12, bla CTX-M-15, bla CTX-M-65), quinolone resistance gene qnrS1, tetracycline resistance genes tetA (A) and tetA (D), aminoglycoside resistance genes aacA4cr and aacC2, streptomycin resistance genes strA and strB, dihydrofolate reductase genes dfrA1 and dfrA14, sulfonamide resistance gene sul2, macrolide resistance gene mph (A), efflux pump gene oqxAB, chloramphenicol acetyltransferase gene catB3, and tunicamycin resistance gene tmrB.
IMP-38-Producing High-Risk Sequence Type 307 Klebsiella pneumoniae Strains from a Neonatal Unit in China.
The study identifies IMP-38-producing high-risk ST307 Klebsiella pneumoniae strains in a neonatal unit in China, highlighting the acquisition of diverse antimicrobial resistance genes, including blaIMP-38, blaCTX-M-3, blaSHV-2A, blaSHV-28, blaTEM-1, aacA4, catB3, oqxA, oqxB, and fosA6.
Prevalence and characteristics of extended-spectrum beta-lactamases-producing Escherichia coli from broiler chickens at different day-age.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-14, blaCTX-M-9, blaCTX-M-55, blaCTX-M-15, blaCTX-M-1, blaCTX-M-65, blaCTX-M-74, and blaCTX-M-25, along with PMQR genes such as qnrS, aac(6′)-Ib-cr, qnrB, and qnrA. Additionally, mutations in the QRDR of gyrA and parC were associated with enrofloxacin resistance in ESBL-producing E. coli isolates from broiler chickens.
Antimicrobial Resistance in Swine Fecal Specimens Across Different Farm Management Systems.
The study identified several AMR genes associated with different antimicrobial classes in swine fecal samples from farms with varying antimicrobial usage levels. These genes included beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, macrolide resistance markers, polymyxin resistance genes, phenicol resistance genes, and trimethoprim resistance genes.
Whole Genome Sequencing and Characterization of Multidrug-Resistant (MDR) Bacterial Strains Isolated From a Norwegian University Campus Pond.
The study identifies multiple AMR genes and mutations in ESBL-producing bacteria from Norwegian freshwater environments, highlighting the presence of multidrug-resistant strains with resistance to various antibiotics including beta-lactams, fluoroquinolones, and sulfonamides.
The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2016.
The report highlights high levels of antimicrobial resistance in zoonotic bacteria such as Salmonella and Campylobacter, with specific emphasis on resistance to fluoroquinolones, tetracyclines, and sulfonamides. It also notes the emergence of multidrug-resistant strains and the presence of ESBL-producing and carbapenemase-producing E. coli in poultry and meat.
The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2017.
The report highlights high levels of antimicrobial resistance in zoonotic bacteria such as Salmonella and Campylobacter, as well as in indicator bacteria like Escherichia coli. Key findings include resistance to multiple antibiotics, including extended-spectrum beta-lactamases (ESBLs), AmpC beta-lactamases, and carbapenemases. Colistin resistance was observed at low levels, and multidrug-resistant strains were prevalent in certain serovars.
Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Drinking Water Samples From a Forcibly Displaced, Densely Populated Community Setting in Bangladesh.
The study identified ESBL-producing E. coli in drinking water samples from Rohingya camps in Bangladesh, highlighting the presence of multidrug-resistant strains with genes such as bla CTX-M-1, bla CTX-M-15, bla TEM, qnrS, and qnrB.
Efficacy of Acacia nilotica aqueous extract in treating biofilm-forming and multidrug resistant uropathogens isolated from patients with UTI syndrome.
The study identified several AMR genes including blaTEM, blaSHV, blaCTX, qnrS, aac(3)-Ia, and mexR in multidrug-resistant uropathogens. These genes conferred resistance to various antibiotics such as ampicillin, ceftazidime, ciprofloxacin, gentamicin, and piperacillin.
Distribution of Class B and Class A β-Lactamases in Clinical Strains of Pseudomonas aeruginosa: Comparison of Phenotypic Methods and High-Resolution Melting Analysis (HRMA) Assay.
The study identified various β-lactamase genes, including bla SHV, bla TEM, bla KPC, bla IMP, bla VIM, and bla GES, in Pseudomonas aeruginosa isolates using HRMA assay. These genes were associated with resistance to multiple β-lactam antibiotics.
Tracking Recombination Events That Occur in Conjugative Virulence Plasmid p15WZ-82_Vir during the Transmission Process.
The study characterizes the recombination events in the conjugative virulence plasmid p15WZ-82_Vir during transmission, identifying multiple antibiotic resistance genes and their roles in the formation of mosaic plasmids that carry both virulence and resistance traits.
Therapeutic Effect and Mechanisms of the Novel Monosulfactam 0073.
The novel monosulfactam 0073 showed potent activity against multidrug-resistant Gram-negative bacteria, including those producing various beta-lactamases such as KPC-2, NDM-1, TEM-1, OXA-48, SHV-11, CTX-M-1, and CIT. It exhibited lower MICs compared to aztreonam and had reduced resistance development potential.
Mobility of β-Lactam Resistance Under Bacterial Co-infection and Ampicillin Treatment in a Mouse Model.
The study identified β-lactam resistance genes including bla CMY–2, bla CTX–M–1, and bla TEM–1B in Escherichia coli O80:H26 and Salmonella strains, demonstrating their transferability under ampicillin treatment in a mouse model.
Molecular Relatedness of Salmonella enterica Typhimurium Isolates from Feces and an Infected Surgical Wound.
The study identified the presence of blaCTX-M-15, blaTEM-1, qnrS-1, qnrB, aac-3, and blaCMY-2 in Salmonella enterica serovar Typhimurium isolates SM043 and SM080, which conferred resistance to third- and fourth-generation cephalosporins and other antibiotics.
Occurrence and Antimicrobial Resistance Traits of Escherichia coli from Wild Birds and Rodents in Singapore.
F Plasmids Are the Major Carriers of Antibiotic Resistance Genes in Human-Associated Commensal Escherichia coli.
The study identifies various antibiotic resistance genes in commensal E. coli isolates, highlighting the prevalence of resistance genes on F plasmids and the role of mobile genetic elements in their dissemination.
F Plasmids Are the Major Carriers of Antibiotic Resistance Genes in Human-Associated Commensal Escherichia coli.
The study identifies various antibiotic resistance genes in commensal E. coli isolates, highlighting the prevalence of resistance genes on F plasmids and the role of mobile genetic elements in their dissemination.
Characteristics of Extended-Spectrum β-Lactamase-Producing Escherichia coli From Dogs and Cats Admitted to a Veterinary Teaching Hospital in Taipei, Taiwan From 2014 to 2017.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-55, bla CTX-M-124, bla CTX-M-194, bla CTX-M-174, bla CTX-M-198, bla CTX-M-214, bla TEM-215, and bla SHV-199, in ESBL-producing E. coli isolates from dogs and cats. These genes conferred resistance to beta-lactam antibiotics such as ceftiofur and ampicillin.
Identification of a Cluster of Extended-spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Sequence Type 101 Isolated From Food and Humans.
The study identifies a cluster of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae sequence type 101 isolated from food and humans, highlighting the potential role of food as a source of multidrug-resistant bacteria transmission to humans.
Report of multidrug resistant bloodstream bacterial infections in systemic lupus erythematosus patients in Southern India
The study identified multidrug-resistant bacterial isolates from bloodstream infections in SLE patients, including E. coli and K. pneumoniae carrying blaTEM and blaCTX-M genes, which confer resistance to several beta-lactam antibiotics.
Antimicrobial Resistance and Biofilm Formation Capacity of Salmonella enterica Serovar Enteritidis Strains Isolated from Poultry and Humans in Poland.
The study identified floR as the most common resistance gene in poultry strains and blaTEM in human strains. adrA, csgD, and sdiA were prevalent in both groups, with adrA being present in 100% of poultry strains.
Antimicrobial resistance and molecular detection of extended spectrum β-lactamase producing Escherichia coli isolates from raw meat in Greater Accra region, Ghana.
The study identified the blaTEM gene in 4% of E. coli isolates from raw meat in Ghana, which conferred resistance to several antibiotics including ampicillin, amikacin, tetracycline, sulphamethoxazole/trimethoprim, and cefuroxime.
Development of an NGS-Based Workflow for Improved Monitoring of Circulating Plasmids in Support of Risk Assessment of Antimicrobial Resistance Gene Dissemination.
The study developed an optimized NGS-based workflow for plasmid reconstruction, enabling the identification of AMR genes such as mcr-1.1, blaTEM-1B, and others, which are critical for understanding the dissemination of antimicrobial resistance.
Phenotypically distinguishing ESBL-producing pathogens using paper-based surface enhanced Raman sensors.
The study demonstrates the use of paper-based surface-enhanced Raman spectroscopy (SERS) sensors to detect beta-lactamase activity in bacterial cultures, specifically identifying resistance to cephalosporins mediated by TEM-1 and SHV-4 beta-lactamases.
Antibiotic resistance and extended-spectrum β-lactamase in Escherichia coli isolates from imported 1-day-old chicks, ducklings, and turkey poults.
The study identified various extended-spectrum beta-lactamase (ESBL) and ampC beta-lactamase genes, including bla TEM, bla SHV, bla CTX-M, bla OXA-1, and ampC, in Escherichia coli isolates from imported 1-day-old poultry. These genes conferred resistance to multiple beta-lactam antibiotics.
Molecular investigation of antibiotic resistant bacterial strains isolated from wastewater streams in Pakistan.
The study identified the presence of the antibiotic resistance genes blaTEM and qnrS2 in Aeromonas spp. and Escherichia spp., indicating their role in conferring resistance to beta-lactam and fluoroquinolone antibiotics.
Emergence of Transferable mcr-9 Gene-Carrying Colistin-Resistant Salmonella enterica Dessau ST14 Isolated from Retail Chicken Meat in Korea.
The study identified the mcr-9 gene in a colistin-resistant Salmonella enterica Dessau ST14 strain isolated from retail chicken meat in Korea, demonstrating its transferability to Escherichia coli. Additionally, the strain carried other resistance genes including aac(6')-Iaa, blaTEM-1B, and qnrS1.
Novel IncFII plasmid harbouring blaNDM-4 in a carbapenem-resistant Escherichia coli of pig origin, Italy.
The study identifies a novel IncFII plasmid, pMOL412_FII, carrying the blaNDM-4 gene, which mediates resistance to carbapenems in a carbapenem-resistant E. coli isolate from a pig in Italy. Additional resistance genes include blaTEM-1B, sul1, sul3, and dfrA12, contributing to resistance against beta-lactams, sulfamethoxazole, and trimethoprim.
Predicting β-lactam resistance using whole genome sequencing in Klebsiella pneumoniae: the challenge of beta-lactamase inhibitors.
The study identifies several beta-lactamase genes, including bla NDM-1, bla OXA-48, bla KPC-8, and bla KPC-14, which confer resistance to various β-lactam antibiotics. It also highlights the importance of considering complex beta-lactamase backgrounds when predicting antimicrobial resistance using whole-genome sequencing.
Impact of RBX2660 on the microbiome and resistome in patients with recurrent Clostridium difficile infection
RBX2660 introduced antibiotic-resistant organisms (AROs) with various resistance genes, including AmpC, TEM-1, CARB, and CTX-M-14, which conferred resistance to multiple antibiotics.
Profiling Virulence and Antimicrobial Resistance Markers of Enterovirulent Escherichia Coli from Fecal Isolates of Adult Patients with Enteric Infections in West Cameroon.
The study identified several AMR genes and mutations in enterovirulent E. coli isolates from adult patients in Cameroon, including blaTEM, blaOxa, cat1, cat2, tetB, tetA, tetG, sul2, and dfrA12, along with mutations in gyrA and parC contributing to quinolone resistance.
High precision Neisseria gonorrhoeae variant and antimicrobial resistance calling from metagenomic Nanopore sequencing.
The study identifies plasmid-mediated resistance genes blaTEM-1 and tetM in Neisseria gonorrhoeae using Nanopore sequencing, demonstrating their presence in clinical samples.
Occurrence and Characterization of Salmonella Isolated From Chicken Breeder Flocks in Nine Chinese Provinces.
The study identified the presence of bla TEM, sul3, sul2, and aaC4 genes in Salmonella isolates from chicken breeder flocks in China, contributing to resistance against ampicillin, cefoxitin, ceftriaxone, sulfamethoxazole, and streptomycin.
Bacterial Profiles and Their Associated Factors of Urinary Tract Infection and Detection of Extended Spectrum Beta-Lactamase Producing Gram-Negative Uropathogens Among Patients with Diabetes Mellitus at Dessie Referral Hospital, Northeastern Ethiopia.
The study identified blaTEM and blaSHV genes in Escherichia coli and Klebsiella pneumoniae isolates, which conferred resistance to ampicillin.
Detection and Profiling of Antibiotic Resistance among Culturable Bacterial Isolates in Vended Food and Soil Samples.
The study identified several antibiotic resistance genes including Bla TEM, StrB, DfrA, TetA, and FloR in bacterial isolates from vended food and soil samples in Embu Town and Kangaru Market, Kenya.
Plasmid mediated penicillin and tetracycline resistance among Neisseria gonorrhoeae isolates from Kenya.
The study identifies plasmid-mediated resistance genes blaTEM-1, blaTEM-239, and tetM in Neisseria gonorrhoeae isolates from Kenya, along with chromosomal mutations in mtrR, penB, and s10 that contribute to resistance.
Plasmid mediated penicillin and tetracycline resistance among Neisseria gonorrhoeae isolates from Kenya.
The study identifies plasmid-mediated resistance genes blaTEM-1, blaTEM-239, and tetM in Neisseria gonorrhoeae isolates from Kenya, along with chromosomal mutations in mtrR, penB, and s10 that contribute to resistance.
Characterization of Hypervirulent Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Among Urinary Tract Infections: The First Report from Iran.
The study identified ESBL genes (bla SHV, bla TEM, bla CTX-M) and PMQR genes (qnrA, qnrB, qnrS) in hypervirulent Klebsiella pneumoniae isolates from urinary tract infections in Iran. These genes contribute to resistance against beta-lactam antibiotics and quinolones.
Genotyping and molecular characterization of antimicrobial resistance in thermophilic Campylobacter isolated from poultry breeders and their progeny in Eastern Spain.
The study identified qnrS, blaTEM, tetC, and ermB genes associated with resistance to quinolones, beta-lactams, tetracyclines, and macrolides in Campylobacter isolates from poultry breeders and their progeny.
Bacterial isolates harboring antibiotics and heavy-metal resistance genes co-existing with mobile genetic elements in natural aquatic water bodies.
The study identified blaTEM, AmpC, qnrS, merB, merP, merT, silE, silP, silS, arsC, IntI, SulI, ISecp1, TN3, and TN21 as significant AMR genes in bacterial isolates from Dal and Wular Lakes in Kashmir, India. These genes were found to confer resistance to various antibiotics and heavy metals, highlighting the co-existence of antibiotic and metal resistance determinants in aquatic environments.
Bacterial isolates harboring antibiotics and heavy-metal resistance genes co-existing with mobile genetic elements in natural aquatic water bodies.
The study identified blaTEM, AmpC, qnrS, merB, merP, merT, silE, silP, silS, arsC, IntI, SulI, ISecp1, TN3, and TN21 as significant AMR genes in bacterial isolates from Dal and Wular Lakes in Kashmir, India. These genes were found to confer resistance to various antibiotics and heavy metals, highlighting the co-existence of antibiotic and metal resistance determinants in aquatic environments.
Bacterial isolates harboring antibiotics and heavy-metal resistance genes co-existing with mobile genetic elements in natural aquatic water bodies.
The study identified blaTEM, AmpC, qnrS, merB, merP, merT, silE, silP, silS, arsC, IntI, SulI, ISecp1, TN3, and TN21 as significant AMR genes in bacterial isolates from Dal and Wular Lakes in Kashmir, India. These genes were found to confer resistance to various antibiotics and heavy metals, highlighting the co-existence of antibiotic and metal resistance determinants in aquatic environments.
Genomic analysis reveals high virulence and antibiotic resistance amongst phage susceptible Acinetobacter baumannii.
The study identified multiple antibiotic resistance genes in phage-susceptible Acinetobacter baumannii strains, including sulfonamide, tetracycline, beta-lactam, aminoglycoside, macrolide, and phenicol resistance genes. These findings highlight the complex resistance profiles of these strains and their potential implications for therapeutic strategies.
Genomic analysis reveals high virulence and antibiotic resistance amongst phage susceptible Acinetobacter baumannii.
The study identified multiple antibiotic resistance genes in phage-susceptible Acinetobacter baumannii strains, including sulfonamide, tetracycline, beta-lactam, aminoglycoside, macrolide, and phenicol resistance genes. These findings highlight the complex resistance profiles of these strains and their potential implications for therapeutic strategies.
Antimicrobial Resistance in Escherichia coli and Resistance Genes in Coliphages from a Small Animal Clinic and in a Patient Dog with Chronic Urinary Tract Infection.
The study identified several antimicrobial resistance genes in E. coli isolates from a dog with chronic urinary tract infection, including blaTEM, dfr, sulI, sulII, and strA. These genes conferred resistance to ampicillin, trimethoprim, and sulfonamides, as well as streptomycin. Additionally, some coliphages were found to carry these resistance genes.
Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of bla(TEM-1B).
The study identifies IS26-mediated amplification of bla(TEM-1B) as the mechanism of piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli, leading to hyperproduction of the beta-lactamase TEM-1B without a fitness cost.
Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of bla(TEM-1B).
The study identifies IS26-mediated amplification of bla(TEM-1B) as the mechanism of piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli, leading to hyperproduction of the beta-lactamase TEM-1B without a fitness cost.
Exploration of the Neisseria Resistome Reveals Resistance Mechanisms in Commensals That May Be Acquired by N. gonorrhoeae through Horizontal Gene Transfer.
The study identifies resistance mechanisms in commensal Neisseria species, including the presence of blaTEM-1, tetM, and gyrA mutations, which can be horizontally transferred to N. gonorrhoeae.
Characterization of Multidrug Resistance Patterns of Emerging Salmonella enterica Serovar Rissen along the Food Chain in China.
The study identified multiple AMR genes in Salmonella enterica serovar Rissen isolates, including tet(A), blaTEM-1B, aadA2, aadA1, aac(6')-Iaa, aph(3")-lld, sul3, and dfrA12, which confer resistance to various antibiotics such as tetracycline, ampicillin, streptomycin, sulfisoxazole, and trimethoprim-sulfamethoxazole.
Sewer biofilm microbiome and antibiotic resistance genes as function of pipe material, source of microbes, and disinfection: field and laboratory studies.
This study identified various antibiotic resistance genes (ARGs) in sewer biofilms, including sul1, blaTEM, tet(G), tet(O), tet(W), and ermF, which were detected in field and simulated sewer biofilm samples. The research also explored the effects of disinfection protocols on biofilm persistence.
Clinical and molecular characteristics of carbapenem non-susceptible Escherichia coli: A nationwide survey from Oman.
The study identified various carbapenemase genes, including blaNDM-5, blaNDM-1, blaNDM-4, blaNDM-7, blaOXA-181, and blaOXA-48, along with extended-spectrum beta-lactamase CTX-M-15, ampC beta-lactamase CMY-42, and penicillinases TEM-1B and OXA-1 in carbapenem-non-susceptible Escherichia coli isolates from Oman.
Antimicrobial resistant and enteropathogenic bacteria in 'filth flies': a cross-sectional study from Nigeria.
The study identified bla CTX-M and bla TEM genes in ESBL-producing E. coli isolated from filth flies in Nigeria, which conferred resistance to several antibiotics including ceftazidime, ceftriaxone, aztreonam, ciprofloxacin, and trimethoprim-sulfamethoxazole.
The Role of Urban Wastewater in the Environmental Transmission of Antimicrobial Resistance: The Current Situation in Italy (2010-2019).
The study identified several AMR genes in urban wastewater treatment plants in Italy, including bla TEM-1, bla AmpC, bla CTX-M-15, bla KPC-3, bla SHV-1, tet A, sul II, erm B, qnr S, int I1, aad A2, dfr 17, aadA 5, aadA 10, sat 1, bla TEM, bla OXA, bla CTX, bla KPC, and tet W. These genes confer resistance to various antibiotics such as beta-lactams, tetracyclines, sulfonamides, macrolides, fluoroquinolones, and aminoglycosides.
The Role of Urban Wastewater in the Environmental Transmission of Antimicrobial Resistance: The Current Situation in Italy (2010-2019).
The study identified several AMR genes in urban wastewater treatment plants in Italy, including bla TEM-1, bla AmpC, bla CTX-M-15, bla KPC-3, bla SHV-1, tet A, sul II, erm B, qnr S, int I1, aad A2, dfr 17, aadA 5, aadA 10, sat 1, bla TEM, bla OXA, bla CTX, bla KPC, and tet W. These genes confer resistance to various antibiotics such as beta-lactams, tetracyclines, sulfonamides, macrolides, fluoroquinolones, and aminoglycosides.
Pathogenicity of Shiga Toxin Type 2e Escherichia coli in Pig Colibacillosis.
The study identified ESBL genes TEM, CTX-M1, and CMY-2 in Stx2e-producing E. coli isolates from diseased pigs, highlighting the prevalence of antimicrobial resistance.
The New Klebsiellapneumoniae ST152 Variants with Hypermucoviscous Phenotype Isolated from Renal Transplant Recipients with Asymptomatic Bacteriuria-Genetic Characteristics by WGS.
The study identified several AMR genes in two hypermucoviscous Klebsiella pneumoniae isolates from renal transplant recipients, including bla CTX-M-15, aac(6')-Ib-cr, and others, indicating resistance to various antibiotics.
A high prevalence of multi-drug resistant Gram-negative bacilli in a Nepali tertiary care hospital and associated widespread distribution of Extended-Spectrum Beta-Lactamase (ESBL) and carbapenemase-encoding genes.
The study identified a high prevalence of multi-drug resistant Gram-negative bacilli carrying ESBL and carbapenemase genes, including bla TEM, bla CTXM-1, bla CTXM-8, bla OXA, bla OXA51, bla OXA23, bla NDM-1, and bla KPC.
Can domestic pigeon be a potential carrier of zoonotic Salmonella?
The study identified several antimicrobial resistance genes in Salmonella enterica serovar Typhimurium isolated from domestic pigeons, including strB, tet(A), floR, sul1, and blaTEM-1, which confer resistance to aminoglycosides, tetracyclines, florfenicol, sulfonamides, and beta-lactams, respectively.
Hospital Wastewater-Important Source of Multidrug Resistant Coliform Bacteria with ESBL-Production.
The study identifies several AMR genes, including bla TEM, bla CTX-M-2, bla CTX-M-8/25, tetA, and tetE, which are associated with multidrug resistance in coliform bacteria from hospital wastewater.
Predictors of Severity and Co-Infection Resistance Profile in COVID-19 Patients: First Report from Upper Egypt.
The study identified various antimicrobial resistance genes in bacterial co-infections among COVID-19 patients, including mecA, NDM-1, KPC, TEM, CTX-M, and SHV. These genes were associated with multidrug-resistant isolates, highlighting the importance of monitoring and managing co-infections in COVID-19 patients.
Novel R-factor borne beta-lactamase of Escherichia coli confering resistance to cephalosporins.
Novel R-factor borne beta-lactamase of Escherichia coli confering resistance to cephalosporins.
Novel R-factor borne beta-lactamase of Escherichia coli confering resistance to cephalosporins.
Novel R-factor borne beta-lactamase of Escherichia coli confering resistance to cephalosporins.
Novel R-factor borne beta-lactamase of Escherichia coli confering resistance to cephalosporins.
Novel R-factor borne beta-lactamase of Escherichia coli confering resistance to cephalosporins.
Antibiotic and Metal Resistance in Escherichia coli Isolated from Pig Slaughterhouses in the United Kingdom.
The study identified the bla TEM gene in three E. coli strains, which conferred resistance to multiple antibiotics including ampicillin, amoxicillin-clavulanic acid, streptomycin, oxytetracycline, sulfonamide, chloramphenicol, and trimethoprim-sulfamethoxazole. Additionally, merA and merC genes were detected in 14 strains, indicating mercury resistance, and silA, silB, and silE genes were found in 19 strains, indicating silver resistance.
Molecular Characteristics of Extraintestinal Pathogenic E. coli (ExPEC), Uropathogenic E. coli (UPEC), and Multidrug Resistant E. coli Isolated from Healthy Dogs in Spain. Whole Genome Sequencing of Canine ST372 Isolates and Comparison with Human Isolates Causing Extraintestinal Infections.
The study identified several AMR genes in canine ST372 isolates, including blaTEM-1A, sul1, aadA1, dfrA1, and mdf(A), which confer resistance to beta-lactams, sulfonamides, aminoglycosides, trimethoprim, and tetracyclines respectively. These genes were found in the genomes of the isolates through whole genome sequencing and in silico analysis.
Colonisation with extended spectrum beta-lactamase-producing and carbapenem-resistant Enterobacterales in children admitted to a paediatric referral hospital in South Africa.
The study identified blaCTX-M as the most prevalent ESBL gene in ESBL-PE isolates, followed by blaTEM and blaSHV. The CRE isolate did not carry common carbapenemase genes.
Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel beta-lactamase.
Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel beta-lactamase.
Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel beta-lactamase.
Characteristics and Epidemiology of Extended-Spectrum β-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae From Red Kangaroo, China.
The study identified multiple AMR genes in a multidrug-resistant Klebsiella pneumoniae isolate from a Red Kangaroo, including beta-lactamases (bla DHA–3, bla SHV–1, bla CTX–M–14, bla TEM–191, bla TEM–1, bla CTX–M–3), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aac(3)-IIa, aac(6′)-Ib-cr, aadA16, arr-3), quinolone resistance genes (qnrS1, qnrB2), macrolide resistance gene (mphA), sulfonamide resistance genes (sul3, sul1), dihydrofolate reductase (dfrA3, dfrA27), chloramphenicol resistance gene (floR), tetracycline resistance genes (tetG, tetR), and multidrug efflux pump (qacEΔ1).
Characteristics and Epidemiology of Extended-Spectrum β-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae From Red Kangaroo, China.
The study identified multiple AMR genes in a multidrug-resistant Klebsiella pneumoniae isolate from a Red Kangaroo, including beta-lactamases (bla DHA–3, bla SHV–1, bla CTX–M–14, bla TEM–191, bla TEM–1, bla CTX–M–3), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aac(3)-IIa, aac(6′)-Ib-cr, aadA16, arr-3), quinolone resistance genes (qnrS1, qnrB2), macrolide resistance gene (mphA), sulfonamide resistance genes (sul3, sul1), dihydrofolate reductase (dfrA3, dfrA27), chloramphenicol resistance gene (floR), tetracycline resistance genes (tetG, tetR), and multidrug efflux pump (qacEΔ1).
Genotypic antimicrobial resistance characterization of E. coli from dairy calves at high risk of respiratory disease administered enrofloxacin or tulathromycin.
The study identified several AMR genes and mutations in E. coli from dairy calves, including aac(6')Ib-cr, bla-CTX-M, bla-TEM, tetA, tetB, and gyrA mutations. These genes and mutations were associated with resistance to various antibiotics such as ciprofloxacin, ceftazidime, tetracycline, and others.
Epigenomics, genomics, resistome, mobilome, virulome and evolutionary phylogenomics of carbapenem-resistant Klebsiella pneumoniae clinical strains.
The study characterizes carbapenem-resistant Klebsiella pneumoniae clinical strains, identifying bla OXA-48, bla NDM-1, bla OXA-181, and bla NDM-7 as key carbapenemase genes. It also identifies a pmrA mutation (M66I) associated with colistin resistance.
Snapshot Study of Whole Genome Sequences of Escherichia coli from Healthy Companion Animals, Livestock, Wildlife, Humans and Food in Italy.
The study identified multiple antimicrobial resistance genes (ARGs) and mutations in Escherichia coli isolates from various sources in Italy, highlighting the prevalence of resistance to tetracycline, sulfonamide, penicillin, fluoroquinolone, and colistin. Key genes included tetA, sul2, blaTEM-1b, mcr-1, qnrS1, and others, along with mutations in gyrA, parC, parE, and pmrB.
Extended-spectrum beta-lactamase-producing Escherichia coli isolated from raw vegetables in South Korea.
The study identified several CTX-M-type beta-lactamase genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, and bla CTX-M-65, in extended-spectrum beta-lactamase-producing Escherichia coli isolates from raw vegetables in South Korea.
Virulence-determinants and antibiotic-resistance genes of MDR-E. coli isolated from secondary infections following FMD-outbreak in cattle.
The study identified the presence of multidrug-resistant E. coli strains carrying the blaTEM, blaCTX, and blaKPC genes, which confer resistance to penicillins, cephalosporins, and carbapenems, respectively.
A Multifactorial Approach for Surveillance of Shigella spp. and Entero-Invasive Escherichia coli Is Important for Detecting (Inter)national Clusters.
The study identified several AMR genes and mutations in Shigella spp. and EIEC isolates, including beta-lactamases (blaTEM-1b, blaOXA-1, blaCTX-M-15, blaCTX-M-32, blaCTX-M-55, blaDHA-1), dihydrofolate reductase variants (dfrA1, dfrA14, dfrA17, dfrA7, dfrA8), sulfonamide resistance genes (sul1, sul2), macrolide resistance genes (erm(B), mphA), and chromosomal mutations in gyrA, parC, and parE associated with ciprofloxacin resistance.
Employing MIC Data for Mink Pathogens to Propose Tentative Epidemiological Cut-Off Values: A Step Toward Rationalizing Antimicrobial Use in Mink.
The study identified several AMR genes in mink pathogens, including beta-lactamases (blaTEM-1, blaCTX-M-1), tetracycline resistance genes (tet(A), tet(B)), aminoglycoside resistance genes (aadA5, aadA1), sulfonamide resistance genes (sul2), dihydrofolate reductase genes (dfrA1, dfrA5, dfrA8, dfrA14), macrolide/lincosamide/streptogramin B resistance genes (erm), lincomycin resistance gene (lnu(A)), spectinomycin resistance gene (spc), and additional sulfonamide and trimethoprim resistance genes (sul1, sul3, dfrK, dfrG).
Aeromonas hydrophila RIT668 and Citrobacter portucalensis RIT669-Potential Zoonotic Pathogens Isolated from Spotted Turtles.
Aeromonas hydrophila RIT668 and Citrobacter portucalensis RIT669 were found to be resistant to several antibiotics including gentamicin, tetracycline, doxycycline, kanamycin, streptomycin, tobramycin, novobiocin, and erythromycin, but susceptible to neomycin and cotrimoxazole. They exhibited multidrug resistance in the planktonic phase and weak biofilm eradication even with neomycin and cotrimoxazole.
Extended Spectrum Beta-Lactamase-Resistant Determinants among Carbapenem-Resistant Enterobacteriaceae from Beef Cattle in the North West Province, South Africa: A Critical Assessment of Their Possible Public Health Implications.
The study identified various carbapenemase and ESBL genes in carbapenem-resistant Enterobacteriaceae isolated from beef cattle in South Africa, highlighting the presence of resistance determinants that could pose public health risks.
Salmonella identified in pigs in Kenya and Malawi reveals the potential for zoonotic transmission in emerging pork markets.
The study identified several AMR genes in Salmonella isolates from pigs in Kenya and Malawi, including dfrA14, sul2, aph(3''-1b), aph(6)-1d, blaTEM-1B, fosA7, tet(A), and tet(J). A single isolate with a gyrA(D87Y) mutation showed resistance to pefloxacin.
Whole-Genome Sequence Analysis of an Extensively Drug-Resistant Salmonella enterica Serovar Agona Isolate from an Australian Silver Gull (Chroicocephalus novaehollandiae) Reveals the Acquisition of Multidrug Resistance Plasmids.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Salmonella enterica serovar Agona isolate from a silver gull, including bla CTX-M-55, dfrA14, sul3, qnrS1, tet(A), bla TEM-1, and others, indicating the acquisition of multidrug resistance plasmids.
Does Shiga Toxin-Producing Escherichia coli and Listeria monocytogenes Contribute Significantly to the Burden of Antimicrobial Resistance in Uruguay?
The study identified several antimicrobial resistance genes in Shiga toxin-producing Escherichia coli (STEC) and Listeria monocytogenes isolates, including aph(3")-Ib, aph(3′)-Ia, aph(6)-Id, blaTEM-1B, sul2, tet(A), fosX, lin, norB, lde, mdrL, and fepA. These genes conferred resistance to various antibiotics such as ampicillin, trimethoprim-sulfamethoxazole, tetracycline, fosfomycin, lincomycin, ciprofloxacin, and erythromycin.
Characterization of integrons and antimicrobial resistance in Salmonella from broilers in Shandong, China.
The study identified several AMR genes in Salmonella isolates from broilers in Shandong, China, including blaTEM, blaOXA, blaCTX-M, blaPSE, aac(6')-Ib-cr, oqxB, qnrB, and mcr-1, which confer resistance to various antibiotics such as ampicillin, enrofloxacin, and polymyxin.
Genomic diversity of Escherichia coli isolates from backyard chickens and guinea fowl in the Gambia.
The study identified the presence of antimicrobial resistance genes, including blaTEM-1A/B, in Escherichia coli isolates from backyard chickens and guinea fowl in the Gambia, highlighting the prevalence of multidrug-resistant strains.
Prevalence, phylogeny, and antimicrobial resistance of Escherichia coli pathotypes isolated from children less than 5 years old with community acquired- diarrhea in Upper Egypt.
The study identified blaTEM, blaCTX-M-15, and DHA genes in Escherichia coli isolates from children with diarrhea, indicating the presence of extended-spectrum beta-lactamases and AmpC beta-lactamases, contributing to multidrug resistance.
Antibiotic Susceptibility and Molecular Characterization of Uropathogenic Escherichia coli Associated with Community-Acquired Urinary Tract Infections in Urban and Rural Settings in South Africa.
The study identified several AMR genes in UPEC isolates, including bla CTX-M, bla TEM, qnrA, qnrB, qnrS, gyrA, parC, aac(6')-Ib-cr, and qepA, which confer resistance to beta-lactams and fluoroquinolones. Multidrug-resistant isolates were also found.
Antibiotic Sensitivity Screening of Klebsiella spp. and Raoultella spp. Isolated from Marine Bivalve Molluscs Reveal Presence of CTX-M-Producing K. pneumoniae.
The study identified the presence of CTX-M-3 and TEM-1 beta-lactamase genes in a K. pneumoniae isolate from marine bivalve molluscs, highlighting the potential for these organisms to act as reservoirs of extended-spectrum beta-lactamase-producing K. pneumoniae.
Tn1 transposition in the course of natural transformation enables horizontal antibiotic resistance spread in Acinetobacter baylyi.
The study characterizes the transposition of Tn1 in Acinetobacter baylyi, demonstrating that the blaTEM-2 gene contributes to ampicillin resistance through horizontal gene transfer via natural transformation.
Molecular detection of extended spectrum beta-lactamase genes in Escherichia coli clinical isolates from diarrhoeic children in Kano, Nigeria.
The study identifies the presence of ESBLs in E. coli isolates from diarrhoeic children in Kano, Nigeria, with bla CTX-M and bla TEM being the most prevalent genes associated with resistance to β-lactam antibiotics.
Multidrug-resistant Escherichia coli and Salmonella spp. isolated from pigeons.
The study identified multidrug-resistant Escherichia coli and Salmonella spp. from pigeons, highlighting resistance to several antibiotics including ampicillin, amoxicillin, gentamicin, tetracycline, erythromycin, and azithromycin.
Occurrence, identification, and antibiogram signatures of selected Enterobacteriaceae from Tsomo and Tyhume rivers in the Eastern Cape Province, Republic of South Africa.
The study identified various beta-lactamase genes (bla TEM, bla CTX-M, bla SHV, bla OXA-1-like, bla PER, bla VIM, bla IMP, bla KPC, bla GES, bla OXA-48-like), plasmid-mediated AmpC beta-lactamase genes (bla EBC, bla ACC, bla FOX, bla CIT), tetracycline resistance genes (tetA, tetB, tetD, tetM), chloramphenicol resistance gene (catII), and sulfonamide resistance gene (sulII) in Enterobacteriaceae isolates from Tsomo and Tyhume rivers.
Prevalence of antibiotic resistance and virulent factors in nosocomial clinical isolates of Pseudomonas aeruginosa from Panamá.
The study identified the presence of the MexAB-OprM efflux pump system, pyoverdine receptor genes (fpvA), and blaTEM beta-lactamase genes in Pseudomonas aeruginosa isolates from Panama, indicating their roles in antibiotic resistance.
Antimicrobial Resistance and Genomic Characterization of OXA-48- and CTX-M-15-Co-Producing Hypervirulent Klebsiella pneumoniae ST23 Recovered from Nosocomial Outbreak.
The study characterizes the AMR genes in a multidrug-resistant hypervirulent Klebsiella pneumoniae ST23 isolate, MAR14-456, which co-produces OXA-48 and CTX-M-15. The isolate shows resistance to multiple antibiotics, including carbapenems, cephalosporins, and aminoglycosides.
Analysis of existence of multidrug-resistant H58 gene in Salmonella enterica serovar Typhi isolated from typhoid fever patients in Makassar, Indonesia.
Resistotyping and extended-spectrum beta-lactamase genes among Escherichia coli from wastewater treatment plants and recipient surface water for reuse in South Africa.
The study identified bla TEM and bla CTX-M genes in Escherichia coli isolates from wastewater treatment plants and surface water, indicating the presence of extended-spectrum beta-lactamase-producing strains with resistance to multiple antibiotics.
Genomic epidemiology of Escherichia coli isolates from a tertiary referral center in Lilongwe, Malawi.
The study identifies the blaCTX-M-15 gene as a major contributor to cephalosporin resistance in Escherichia coli isolates from Malawi, along with other AMR genes such as aac(3)-IIa, aac(3)-IId, aadA5, ant(3'')-Ih, aph(3'')-Ib, aph(3')-Ia, aph(6)-Id, strA, strB, acrF, emrD, mdtM, blaTEM-1, catA1, catB3, dfrA17, sul2, mph(A), and tet(A).
Genomic Characteristics of Colistin-Resistant Salmonella enterica subsp. enterica Serovar Infantis from Poultry Farms in the Republic of Serbia.
The study identified the fosfomycin resistance gene fosA7 and the vgaA gene in Salmonella enterica subsp. enterica serovar Infantis isolates from poultry farms in Serbia. Mutations in the pmrB gene were associated with colistin resistance.
Antibiotic Resistance and Virulence of Extraintestinal Pathogenic Escherichia coli (ExPEC) Vary According to Molecular Types.
The study identifies several antibiotic resistance genes (ARGs) and virulence factors (VFs) in extraintestinal pathogenic Escherichia coli (ExPEC) strains, highlighting their association with molecular types and resistance profiles.
A Biological Inventory of Prophages in A. baumannii Genomes Reveal Distinct Distributions in Classes, Length, and Genomic Positions.
The study identifies several antimicrobial resistance (AMR) genes encoded in prophages within Acinetobacter baumannii genomes, including blaOXA-23, blaNDM-1, blaADC-5, blaOXA-67, blaOXA-115, blaTEM-12, aac(3)-I, aac(3)-Id, aacA16, aph(3')-Ia, aph(3')-VI, aph(6)-Id, aph(3'')-Ib, msr(E), mph(E), and sul2. These genes confer resistance to various antibiotics such as carbapenems, penicillins, cephalosporins, monobactams, aminoglycosides, macrolides, and sulfonamides.
In vivo diversification of target genomic sites using processive base deaminase fusions blocked by dCas9.
The study characterizes several BD-T7RNAP fusions that introduce specific mutations in DNA, demonstrating their utility in directed evolution processes.
Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae Complex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid.
The study identifies the blaCTX-M-1 gene carried on an IncI1/ST3 plasmid in Enterobacter cloacae and Escherichia coli isolates from humans and wild animals in Guadeloupe, highlighting the dissemination of this resistance determinant in the environment.
In Vitro Assessment of Antimicrobial Resistance Dissemination Dynamics during Multidrug-Resistant-Bacterium Invasion Events by Using a Continuous-Culture Device.
The study investigates the dissemination dynamics of antimicrobial resistance (AMR) from multidrug-resistant (MDR) Escherichia coli to a community of pathogenic Salmonella enterica using a continuous-culture device. It highlights the role of horizontal gene transfer (HGT) and vertical gene transfer (VGT) in AMR dissemination, demonstrating that environmental tetracycline contamination can significantly enhance HGT and promote AMR dissemination.
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing.
The study identified various AMR genes in E. coli isolates from bloodstream infections, including genes conferring resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, and trimethoprim. Additionally, mutations in quinolone resistance-determining regions of gyrA, parC, and parE were associated with ciprofloxacin resistance.
A Clinical Extensively-Drug Resistant (XDR) Escherichia coli and Role of Its β-Lactamase Genes.
The study identifies bla NDM-5 as a key determinant of resistance to beta-lactam/BLI combinations in the XDR E. coli W60 strain, and highlights the role of the ble MBL gene in enhancing this resistance. Additionally, a non-functional truncated bla TEM gene (bla TEM-W60) was found on plasmid pECW602.
Antimicrobial resistance and gene regulation in Enteroaggregative Escherichia coli from Egyptian children with diarrhoea: Similarities and differences.
The study identified multiple antibiotic resistance genes in Enteroaggregative Escherichia coli (EAEC) isolates from Egyptian children with diarrhea, including bla CTX-M-14b, bla CTX-M-15, bla TEM-1B, aadA1, aph (3')-Ib, aph (3')-Ia, aph (6)-Id, dfrA1, mdfA, sul2, and tetA, which contribute to multidrug resistance.
Isolation of multidrug-resistant Escherichia coli, Staphylococcus spp., and Streptococcus spp. from dogs in Chattogram Metropolitan Area, Bangladesh.
The study identified multidrug-resistant Escherichia coli, Staphylococcus spp., and Streptococcus spp. from dogs in Bangladesh, highlighting the presence of resistance genes such as bla TEM, bla CTX-M, tet A, and Sul- II.
Colistin-resistant Enterobacter kobei carrying mcr-9.1 and bla(CTX-M-15) infecting a critically endangered franciscana dolphin (Pontoporia blainvillei), Brazil.
The study reports the emergence of the mcr-9.1 gene in a colistin-resistant Enterobacter kobei strain isolated from a critically endangered franciscana dolphin in Brazil, along with various other AMR genes.
Molecular analysis of blaSHV, blaTEM, and blaCTX-M in extended-spectrum β-lactamase producing Enterobacteriaceae recovered from fecal specimens of animals.
The study identified blaCTX-M, blaTEM, and blaSHV genes in ESBL-producing Enterobacteriaceae from animal fecal samples, highlighting their prevalence and distribution among different bacterial species.
Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal Salmonella enterica.
The study identified several β-lactamase genes, including bla CTX-M-5, bla OXA-1, bla CTX-M-15, bla CTX-M-3, and bla TEM-1, which contribute to extended-spectrum β-lactamase (ESBL) production in multidrug-resistant non-typhoidal Salmonella enterica isolates. Additionally, a mutation in the gyrA gene (D87N) was linked to quinolone resistance.
Identifying novel beta-lactamase substrate activity through in silico prediction of antimicrobial resistance.
The study identified and experimentally validated 22 previously unknown beta-lactamase substrate activities, including novel resistance mechanisms conferred by genes such as blaCMY-2, blaCTX-M-15, blaCTX-M-3, blaCTX-M-27, blaTEM-1, blaTEM-30, and blaOXA-1.
Identifying novel beta-lactamase substrate activity through in silico prediction of antimicrobial resistance.
The study identified and experimentally validated 22 previously unknown beta-lactamase substrate activities, including novel resistance mechanisms conferred by genes such as blaCMY-2, blaCTX-M-15, blaCTX-M-3, blaCTX-M-27, blaTEM-1, blaTEM-30, and blaOXA-1.
Homology analysis between clinically isolated extraintestinal and enteral Klebsiella pneumoniae among neonates.
The study identified various beta-lactamase genes, including SHV, TEM-1, CTX-M-1, CTX-M-14, CTX-M-15, CMY-8, and NDM-1, which confer resistance to multiple antibiotics in Klebsiella pneumoniae isolates from neonates.
Multidrug-Resistant Listeria Species Shows Abundance in Environmental Waters of a Key District Municipality in South Africa.
The study identified multiple antimicrobial resistance genes in Listeria species isolated from environmental waters, including sulI, tetA, blaTEM, and blaCIT, which confer resistance to sulfonamides, tetracyclines, and beta-lactams.
Antimicrobial Resistance in Escherichia coli Strains Isolated from Humans and Pet Animals.
The study identifies several AMR genes in E. coli strains isolated from humans and pet animals, including blaTEM, qnrS1, qnrB1, blaCMY-2, blaCMY-59, tetA, tetB, sul1, sul2, and sul3, which confer resistance to various antibiotics such as beta-lactams, quinolones, tetracyclines, and sulfonamides.
Adaptive Processes Change as Multiple Functions Evolve.
The study characterizes the resistance mechanisms of bla TEM-50 and bla TEM-85 beta-lactamase variants, highlighting their distinct evolutionary responses to antibiotics and the impact of epistasis on resistance development.
Adaptive Processes Change as Multiple Functions Evolve.
The study characterizes the resistance mechanisms of bla TEM-50 and bla TEM-85 beta-lactamase variants, highlighting their distinct evolutionary responses to antibiotics and the impact of epistasis on resistance development.
Study on Bacteria Isolates and Antimicrobial Resistance in Wildlife in Sicily, Southern Italy.
The study identified the presence of blaTEM, sulII, and tetA genes in a limited number of bacterial isolates from wildlife in Sicily, indicating a low prevalence of antimicrobial resistance genes in the studied population.
Detection and characterization of ESBL-producing Enterobacteriaceae from the gut of subsistence farmers, their livestock, and the surrounding environment in rural Nepal.
The study identified bla CTX-M-15 as the predominant ESBL gene in ESBL-producing Enterobacteriaceae isolates from subsistence farming communities in Nepal, highlighting the high prevalence of this gene in human, animal, and environmental samples.
Antibiotic resistance plasmid composition and architecture in Escherichia coli isolates from meat.
The study characterizes various AMR genes in plasmids from meat-derived E. coli isolates, highlighting the diversity and clustering of resistance genes such as bla CTX-M-1, aadA5, sul2, and others, along with their association with specific plasmid incompatibility groups.
Antibiotic resistance plasmid composition and architecture in Escherichia coli isolates from meat.
The study characterizes various AMR genes in plasmids from meat-derived E. coli isolates, highlighting the diversity and clustering of resistance genes such as bla CTX-M-1, aadA5, sul2, and others, along with their association with specific plasmid incompatibility groups.
Higher prevalence of multidrug-resistant extended-spectrum beta-lactamases producing Escherichia coli in unorganized pig farms compared to organized pig farms in Mizoram, India.
The study identified several AMR genes, including bla TEM, bla CTX-M, bla CMY, tetA, tetB, sul1, sul2, aadA, and dfrIa, in multidrug-resistant E. coli isolates from both organized and unorganized pig farms in Mizoram, India.
Characterization of Enterococci- and ESBL-Producing Escherichia coli Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified several AMR genes in Enterococcus and ESBL-producing E. coli isolates from bovine mastitis cases in Egypt, including erm(B), tetL, aac-aphD, vanA, and vanB.
Prevalence of ESβL, AmpC and Colistin-Resistant E. coli in Meat: A Comparison between Pork and Wild Boar.
The study identified bla CTX-M1, bla TEM, bla SHV, and bla CTX-M2 genes in E. coli isolates from pork and wild boar meat, indicating the presence of extended-spectrum beta-lactamase (ESβL) resistance. No mcr-1 gene was found in colistin-resistant E. coli isolates from wild boar meat.
Genomic Analysis of Antimicrobial Resistance and Resistance Plasmids in Salmonella Serovars from Poultry in Nigeria.
The study identified various antimicrobial resistance genes in Salmonella isolates from Nigerian poultry, including aac(6')-Ia, aac(6')-Ib, aadA7, aph(3")-Ia, aph(3")-Ib, aph(6')-Id, aph(6')-Ic, aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-IIa, aac(3)-Id, sul1, sul2, sul3, tet(A), tet(M), qnrS1, qnrB19, blaTEM, dfrA14, dfrA15, dfrA17, catA1, cmlA1, and floR. Mutations in gyrA (Ser83Phe, Asp87Tyr) and parC (Thr57Ser, Ser80Ile) were also associated with resistance to nalidixic acid and ciprofloxacin.
Characterization of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolates from Jurong Lake, Singapore with Whole-Genome-Sequencing.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-8, bla CTX-M-27, bla CTX-M-14, and bla CTX-M-55, along with mcr-1.1 and mcr-3.1 for colistin resistance. Additionally, various other resistance genes such as qnrS1, mdf(A), mph(A), and others were found in the isolates, indicating multidrug resistance.
Resistance determinants and their genetic context in enterobacteria from a longitudinal study of pigs reared under various husbandry conditions.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, and bla CMY-2, which confer resistance to various beta-lactam antibiotics in enterobacteria from pigs. Additionally, bla IMP-7 was found to confer resistance to carbapenems in Providencia rettgeri.
The occurrence of CTX-M-producing E. coli in the broiler parent stock in Korea.
The study identified CTX-M-1, CTX-M-14, CTX-M-15, and CTX-M-65 beta-lactamase genes in cefotaxime-resistant E. coli isolates from broiler parent stock in Korea, highlighting the prevalence of extended-spectrum beta-lactamase-producing E. coli and their multidrug resistance characteristics.
Effects of in ovo probiotic administration on the incidence of avian pathogenic Escherichia coli in broilers and an evaluation on its virulence and antimicrobial resistance properties.
The study identified various antimicrobial resistance genes in APEC isolates, including blaTEM, aac(3)-VIa, aac(3)-VIb, aadA, tetA, tetB, dfr7, qacEΔ, qnr, sul1, intl1, arsC, and merA. These genes conferred resistance to multiple antibiotics such as beta-lactams, aminoglycosides, tetracyclines, quinolones, sulfonamides, and heavy metals.
Distribution of Beta-Lactamase Producing Gram-Negative Bacterial Isolates in Isabela River of Santo Domingo, Dominican Republic.
The study identified several beta-lactamase genes, including bla TEM, bla OXA, bla SHV, and bla KPC, as well as other resistance genes such as CTX-M-15, CTX-M-55, OXA-1, OXA-72, OXA-132, KPC-3, QnrS1, QnrB19, sul2, sul1, dfrA12, dfrA14, dfrA17, mphA, aadA, aadA2, aadA5, ampC, ampC1, ampH, PmrF, bacA, and eptA, in various Gram-negative bacterial isolates from the Isabela River in the Dominican Republic.
Molecular Detection of Antibiotic-Resistant Genes in Pseudomonas aeruginosa from Nonclinical Environment: Public Health Implications in Mthatha, Eastern Cape Province, South Africa.
The study identified bla SHV, bla TEM, and bla CTX-M genes in Pseudomonas aeruginosa isolates from nonclinical environments, indicating the presence of extended-spectrum beta-lactamase (ESBL) resistance mechanisms.
Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya.
The study identified several AMR genes in Salmonella isolates from Kenya, including blaTEM-1, aadA1, strA, strB, catA1, dhfr1, sul1, and sul2, which confer resistance to various antibiotics such as penicillins, cephalosporins, streptomycin, chloramphenicol, trimethoprim, and sulfonamides.
Molecular Epidemiology and Characterization of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Urine at a Teaching Hospital in Taiwan.
The study identified several AMR genes and mutations contributing to carbapenem resistance in K. pneumoniae isolates from urine, including bla TEM, bla SHV, bla CTX-M, bla DHA, bla KPC, bla VIM, and mutations in ompK35 and ompK36.
Molecular Characterization of Carbapenemase-Producing Klebsiella pneumoniae Isolated from Egyptian Pediatric Cancer Patients Including a Strain with a Rare Gene-Combination of β-Lactamases.
The study identified the presence of multiple carbapenemase genes, including bla OXA-48, bla NDM-1, and bla IMP-1, in carbapenem-resistant Klebsiella pneumoniae isolates from Egyptian pediatric cancer patients. It also reported a rare combination of these genes in one isolate. The study highlights the dissemination of multidrug-resistant clones among hospital wards.
Prevalence, antimicrobial resistance, and genotyping of Shiga toxin-producing Escherichia coli in foods of cattle origin, diarrheic cattle, and diarrheic humans in Egypt.
The study identified carbapenemase-encoding genes (bla VIM, bla NDM-1) and extended-spectrum beta-lactamase (ESBL)-encoding genes (bla TEM, bla CTX-M1, bla OXA-1) in Shiga toxin-producing Escherichia coli (STEC) isolates from cattle and human sources in Egypt. These genes conferred resistance to various antibiotics, including carbapenems and beta-lactams.
The Animal-foods-environment interface of Klebsiella pneumoniae in Germany: an observational study on pathogenicity, resistance development and the current situation.
The study identifies several AMR genes, including bla CTX-M-15, bla OXA-48, bla SHV-1, bla SHV-2, bla SHV-27, bla TEM-1, aac(3)-IIc, qnrS1, and mcr-1, in Klebsiella pneumoniae isolates from various non-human sources in Germany. Fluoroquinolone resistance was associated with mutations in GyrA and ParC.
High β-lactam resistance in Gram-negative bacteria associated with kennel cough and cat flu in Egypt.
The study identified various β-lactam resistance genes, including bla SHV, bla CTX-M, bla TEM, bla CMY, and bla ACT, as well as qnrS, which confer resistance to β-lactams and quinolones in Gram-negative bacteria associated with kennel cough and cat flu in Egypt.
Detection of TEM and CTX-M Genes in Escherichia coli Isolated from Clinical Specimens at Tertiary Care Heart Hospital, Kathmandu, Nepal.
The study identified the presence of bla CTX-M and bla TEM genes in Escherichia coli isolates, which are responsible for extended-spectrum beta-lactamase (ESBL) production, leading to resistance against cephalosporins.
Endophytic Lifestyle of Global Clones of Extended-Spectrum beta-lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?
The study identifies multiple AMR genes in endophytic ESBL-producing Enterobacterales isolated from fresh vegetables, highlighting their potential role in the spread of antibiotic resistance.
Multidrug Resistant Klebsiella pneumoniae ST101 Clone Survival Chain From Inpatients to Hospital Effluent After Chlorine Treatment.
The study identifies multiple AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae ST101 clone, including blaCTX-M-15, blaOXA-48, blaOXA-1, blaSHV-106, blaTEM-150, aac(3)-IIa, aac(6')-Ib-cr, oqxA10, oqxB17, fosA, catB3, dfrA14, tet(D), and mutations in mgrB, ompK35, gyrA, and parC.
Serogroups, and drug resistance of nontyphoidal Salmonella in symptomatic patients with community-acquired diarrhea and chicken meat samples in Tehran.
The study identified the presence of bla TEM gene in Salmonella isolates from chicken meat samples, which conferred resistance to ceftriaxone and cefoxitin.
Wildlife as Sentinels of Antimicrobial Resistance in Germany?
The study identified various AMR genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-14-like, bla CMY-2-like, and bla TEM-1, in Escherichia coli isolates from wild boars, roe deer, and wild ducks and geese in Germany. These genes conferred resistance to beta-lactam antibiotics such as cefotaxime, ceftazidime, and ampicillin.
Nonnutritive sweeteners can promote the dissemination of antibiotic resistance through conjugative gene transfer.
Nonnutritive sweeteners such as saccharine, sucralose, aspartame, and acesulfame potassium promote plasmid-mediated conjugative transfer of antibiotic resistance genes, enhancing the spread of resistance.
Genome-wide genetic marker analysis and genotyping of Escherichia fergusonii strain OTSVEF-60.
The study identified multiple antimicrobial resistance genes in Escherichia fergusonii strain OTSVEF-60, including aadA2, blaTEM-1, dfrA12, qnrS1, sul1, sul2, and tet(A), which confer resistance to aminoglycosides, beta-lactams, diaminopyrimidines, fluoroquinolones, sulfonamides, and tetracyclines.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
High Prevalence of Drug Resistance and Class 1 Integrons in Escherichia coli Isolated From River Yamuna, India: A Serious Public Health Risk.
The study identified several AMR genes including bla TEM-1, bla CTX-M-15, tetA, qnrS1, strA-strB, and armA in E. coli isolates from the Yamuna River, highlighting the significant public health risk posed by these resistant strains.
Molecular investigation of an outbreak associated with total parenteral nutrition contaminated with NDM-producing Leclercia adecarboxylata.
The study identified NDM-1, TEM-1B, and SHV-12 carbapenemase genes along with various other AMR genes in Leclercia adecarboxylata isolates causing an outbreak linked to contaminated TPN.
Taxonomy, virulence determinants and antimicrobial susceptibility of Aeromonas spp. isolated from bacteremia in southeastern China.
The study identified several beta-lactamase genes (blaTEM, blaSHV, blaAQU-1, blaMOX, blaCepH, blaCphA) and the aac(6')-Ib-cr gene associated with antimicrobial resistance in Aeromonas isolates from bacteremia cases in southeastern China.
Molecular characterization of extended-spectrum beta-lactamase-producing Escherichia coli isolated from postpartum uterine infection in dairy cattle in India.
The study identified a high prevalence of ESBL-producing E. coli in postpartum uterine infections in dairy cattle in India, with bla CTX-M, bla TEM, and bla SHV genes being the most common. These genes confer resistance to various β-lactam antibiotics.
Detection of Cephalosporin and Fluoroquinolone Resistance Genes via Novel Multiplex qPCR in Fecal Salmonella Isolates From Northern Californian Dairy Cattle, 2002-2016.
The study detected the presence of bla CMY–2 and bla TEM genes in Salmonella isolates from dairy cattle, indicating resistance to cephalosporins. No PMQR genes or bla CTX–M were found.
Diarrhea in an infant due to Shigella flexneri 1 carrying multiple cephalosporinase-encoding genes.
The study identifies four different beta-lactamase genes (bla CTX-M-15, bla EC-8, bla OXA-1, and bla TEM-1) in a multidrug-resistant Shigella flexneri 1 strain, contributing to resistance against various cephalosporins.
Institutional outbreak involving multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 at a cancer center in Tokyo, Japan.
The study identified multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 (ST78) strains causing an institutional outbreak. These strains carried blaIMP-1 and blaIMP-11 genes on IncHI2 and IncL/M plasmids, along with various other resistance genes such as aac(6')-IIc, qnrB6, fosA, sul1, and tet(B).
Detection of bla (OXA-1), bla (TEM-1), and Virulence Factors in E. coli Isolated From Seals.
The study detected bla(OXA-1) and bla(TEM-1) genes in E. coli isolates from seals, indicating the presence of beta-lactamase encoding genes and highlighting the significance of marine mammals as indicators of antimicrobial resistance in the environment.
Analysis of antibiotic resistance phenotypes and genes of Escherichia coli from healthy swine in Guizhou, China.
The study identified multiple antibiotic resistance genes in Escherichia coli isolates from healthy swine in Guizhou, China, highlighting the prevalence of multidrug resistance, particularly for tetracycline, doxycycline, and sulfisoxazole. Key genes included blaTEM, blaCTX-M-9G, aac(3')-IV, aadA1, aadA2, floR, qnrS, oqxA, and mcr-1.
Molecular characterization and antimicrobial resistance of potentially human-pathogenic Escherichia coli strains isolated from riding horses.
The study identified blaTEM as the most prevalent antimicrobial resistance gene among E. coli isolates from riding horses, conferring resistance to amoxicillin/clavulanic acid and ceftriaxone.
Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity.
The study demonstrates that the TEM-1 β-lactamase evolved from an ancestral enzyme with broader substrate specificity through a series of hinge-shift mutations, resulting in increased specificity for penicillins.
Prevalence and antimicrobial resistance of Klebsiella species isolated from clinically ill companion animals.
The study identified several extended-spectrum cephalosporin (ESC) resistance genes, including blaCTX-M-15, blaCTX-M-3, blaCTX-M-65, blaDHA-1, blaCMY-2, blaSHV-1, blaSHV-11, blaSHV-28, and blaTEM-1, in Klebsiella pneumoniae and Klebsiella oxytoca strains isolated from clinically ill companion animals. These genes were associated with resistance to various beta-lactam antibiotics.
Genetic Characterization of AmpC and Extended-Spectrum Beta-Lactamase Phenotypes in Escherichia coli and Salmonella From Alberta Broiler Chickens.
The study identified bla CMY-2 and bla TEM genes in E. coli and Salmonella isolates from Alberta broiler chickens, contributing to beta-lactam resistance. Additionally, aadA, aadA1a, and aadA2 genes were found to confer resistance to streptomycin.
Detection of extended spectrum beta-lactamase genes in Pseudomonas aeruginosa isolated from patients in rural Eastern Cape Province, South Africa.
The study identified blaTEM, blaSHV, and blaCTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) resistance in Pseudomonas aeruginosa isolates from the Eastern Cape Province, South Africa. Additionally, blaIMP was detected in a small percentage of isolates.
Characterization of antibiotic resistance profiles in Pseudomonas aeruginosa isolates from burn patients.
The study identifies blaCTX-M2, blaPER, and blaTEM as the primary ESBL genes in MDR P. aeruginosa isolates from burn patients in Algeria, highlighting the spread of these resistance genes in the region.
Prevalence and Antimicrobial Resistance of Salmonella Isolated From Dead-in-Shell Chicken Embryos in Shandong, China.
The study identified bla TEM, bla PSE, and qnrS as the main antimicrobial resistance genes in Salmonella isolates from dead-in-shell chicken embryos in Shandong, China, with bla TEM being the most common beta-lactamase gene and qnrS showing high prevalence.
Genetic but No Phenotypic Associations between Biocide Tolerance and Antibiotic Resistance in Escherichia coli from German Broiler Fattening Farms.
The study identified various AMR genes in E. coli isolates from German broiler farms, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-1C, blaCTX-M-1, blaCMY-2), quinolone resistance genes (qnrB19, qnrS1), chloramphenicol resistance gene (cat1), tetracycline resistance genes (tetA, tetB), sulfonamide resistance genes (sul1, sul2), dihydrofolate reductase genes (drfA1, drfA5, drfA14, drfA17), aminoglycoside resistance gene (aadA1), and efflux pump genes (sugEp, qacEΔ1, mdfA).
Genetic but No Phenotypic Associations between Biocide Tolerance and Antibiotic Resistance in Escherichia coli from German Broiler Fattening Farms.
The study identified various AMR genes in E. coli isolates from German broiler farms, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-1C, blaCTX-M-1, blaCMY-2), quinolone resistance genes (qnrB19, qnrS1), chloramphenicol resistance gene (cat1), tetracycline resistance genes (tetA, tetB), sulfonamide resistance genes (sul1, sul2), dihydrofolate reductase genes (drfA1, drfA5, drfA14, drfA17), aminoglycoside resistance gene (aadA1), and efflux pump genes (sugEp, qacEΔ1, mdfA).
Genetic but No Phenotypic Associations between Biocide Tolerance and Antibiotic Resistance in Escherichia coli from German Broiler Fattening Farms.
The study identified various AMR genes in E. coli isolates from German broiler farms, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-1C, blaCTX-M-1, blaCMY-2), quinolone resistance genes (qnrB19, qnrS1), chloramphenicol resistance gene (cat1), tetracycline resistance genes (tetA, tetB), sulfonamide resistance genes (sul1, sul2), dihydrofolate reductase genes (drfA1, drfA5, drfA14, drfA17), aminoglycoside resistance gene (aadA1), and efflux pump genes (sugEp, qacEΔ1, mdfA).
Characterization of Extended-Spectrum β-Lactamase-Producing and AmpC β-Lactamase-Producing Enterobacterales Isolated from Companion Animals in Korea.
The study identified several extended-spectrum β-lactamase (ESBL) and AmpC β-lactamase genes, including bla TEM, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla CTX-M-61, bla CTX-M-27, bla CTX-M-65, bla CIT, bla DHA, bla EBC, and bla SHV, in various Enterobacterales isolates from companion animals in South Korea.
Antimicrobial Resistance Genes and Diversity of Clones among ESBL- and Acquired AmpC-Producing Escherichia coli Isolated from Fecal Samples of Healthy and Sick Cats in Portugal.
The study identified various ESBL and qAmpC genes in E. coli isolates from cats, highlighting the presence of bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-27, bla CTX-M-9, bla TEM, bla SHV-28, and bla CMY-2, along with other resistance genes such as tet(A), tet(B), sul1, sul2, aac(6')-Ib-cr, and armA.
Acinetobacter baumannii Antibiotic Resistance Mechanisms.
The paper reviews various beta-lactamases and other resistance mechanisms in Acinetobacter baumannii, focusing on their roles in resistance to beta-lactams, aminoglycosides, and other antibiotics.
Antimicrobial Resistance Profile and ExPEC Virulence Potential in Commensal Escherichia coli of Multiple Sources.
The study identified several AMR genes, including blaCTX-M, mcr-1, and qnrS1, which confer resistance to cephalosporins, colistin, and fluoroquinolones, respectively, in commensal E. coli from various sources.
Multicentre study of the burden of multidrug-resistant bacteria in the aetiology of infected diabetic foot ulcers.
The study identified various AMR genes including bla CTX-M, bla TEM, bla SHV, mecA, bla VIM, bla KPC, and bla NDM in multidrug-resistant bacteria causing infected diabetic foot ulcers. These genes conferred resistance to beta-lactams, carbapenems, and other antibiotics.
Extended-spectrum ß-lactamase-producing Escherichia coli among humans, chickens and poultry environments in Abuja, Nigeria.
The study identified bla CTX-M, bla TEM-1, and mcr-1.1 genes in ESBL-EC isolates from humans, chickens, and poultry environments in Abuja, Nigeria, highlighting the prevalence of multidrug-resistant E. coli and the potential for zoonotic transmission.
Extended-spectrum beta-lactamase-producing strains among diarrhoeagenic Escherichia coli-prospective traveller study with literature review.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-9, bla TEM, bla SHV, and bla CTX-M-15, in diarrhoeagenic Escherichia coli (DEC) strains from travellers. These genes confer resistance to beta-lactam antibiotics such as cefoxitin, cefotaxime, and ceftazidime.
Comprehensive Pathogen Identification, Antibiotic Resistance, and Virulence Genes Prediction Directly From Simulated Blood Samples and Positive Blood Cultures by Nanopore Metagenomic Sequencing.
The study demonstrates the use of nanopore sequencing for rapid identification of pathogens, antibiotic resistance genes, and virulence genes from simulated blood samples and positive blood cultures. It identified 39 antibiotic resistance genes and 77 virulence genes in a Klebsiella pneumoniae strain, including blaKPC-2, blaSHV-12, blaTEM-1, blaCTX-M-65, rmtB, aadA, AAC(6')-IIb, baeR, mdtABC, acrAB, oqxAB, tet, H-NS, gyrA, and parC.
Characterization of antimicrobial susceptibility, extended-spectrum β-lactamase genes and phylogenetic groups of Shigatoxin producing Escherichia coli isolated from patients with diarrhea in Iran.
The study identified the presence of extended-spectrum beta-lactamase (ESBL) genes, including blaTEM, blaCTX-M9, blaSHV, and blaOXA, in Shigatoxin-producing Escherichia coli isolates from patients with diarrhea in Iran. These genes confer resistance to beta-lactam antibiotics, particularly ampicillin.
Isolation and detection of antibiotics resistance genes of Escherichia coli from broiler farms in Sukabumi, Indonesia.
The study identified four antibiotic resistance genes in Escherichia coli isolates from broiler farms in Sukabumi, Indonesia: tetA, blaTEM, gyrA, and ermB. These genes conferred resistance to tetracycline, oxytetracycline, ampicillin, nalidixic acid, ciprofloxacin, enrofloxacin, and erythromycin.
Genomic Diversity and Virulence Potential of ESBL- and AmpC-β-Lactamase-Producing Escherichia coli Strains From Healthy Food Animals Across Europe.
The study identifies various ESBL and AmpC beta-lactamase genes, including bla SHV-12, bla CTX-M-1, bla CTX-M-2, bla CTX-M-14, bla CTX-M-15, bla TEM-52, and bla CMY-2, along with the mcr-1 gene conferring colistin resistance in E. coli isolates from food animals in Europe.
Genomic Characterization of Salmonella enterica Isolates From Retail Meat in Beijing, China.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from retail meat in Beijing, including beta-lactamases (blaCTX-M-55, blaCTX-M-14, blaCTX-M-65), aminoglycoside resistance genes (aac(6')-Iaa, aph(6)-Id, aph(3")-Ib), sulfonamide resistance gene (sul2), beta-lactamase (blaTEM-1B), quinolone resistance genes (qnrS1), and colistin resistance genes (mcr-1.1, mcr-9).
Antimicrobial Resistance Glides in the Sky-Free-Living Birds as a Reservoir of Resistant Escherichia coli With Zoonotic Potential.
The study identified multiple AMR genes and mutations in E. coli from free-living birds, highlighting the zoonotic potential of these resistant strains. Key findings include bla CTX-M-15, bla CMY-2, bla SHV-12, bla TEM-1B, qnrS1, qnrB19, mcr-1, fosA7, aac(3)-IIa, ant(3")-Ia, aph(3")-Ib, and aph(6)-Id, as well as mutations in gyrA, parC, and parE.
AMR-Diag: Neural network based genotype-to-phenotype prediction of resistance towards β-lactams in Escherichia coli and Klebsiella pneumoniae.
The study identified several β-lactamase genes including TEM-1, CTX-M-15, NDM-5, SHV, and OXA that confer resistance to β-lactam antibiotics in E. coli and K. pneumoniae. These genes were validated through WGS and phenotypic characterization.
Limited and Strain-Specific Transcriptional and Growth Responses to Acquisition of a Multidrug Resistance Plasmid in Genetically Diverse Escherichia coli Lineages.
The study identified the ESBL plasmid pLL35 carrying blaCTX-M-15, TEM-112, and OXA-9, which conferred varying levels of cefotaxime resistance across different E. coli strains. The transcriptional response to plasmid acquisition was limited and strain-specific, with minimal global changes in gene expression.
A novel framework for engineering protein loops exploring length and compositional variation.
The study demonstrates the engineering of the TEM-1 beta-lactamase Ω-loop to enhance ceftazidime resistance through InDel assembly, identifying novel variants with altered loop compositions and lengths.
Antimicrobial Resistance Genes in ESBL-Producing Escherichia coli Isolates from Animals in Greece.
The study identified several AMR genes in ESBL-producing E. coli isolates from animals in Greece, including bla CTX-M-1/15, bla TEM, aadA1, aadA2, aphA, strA, strB, sul1, sul2, sul3, dfrA1, dfrA5, dfrA7, dfrA12, dfrA14, dfrA15, dfrA17, dfrA19, mph, mrx, intI1, tnpISE cp1, qnrS, and qnrB.
A Real-Time Thermal Sensor System for Quantifying the Inhibitory Effect of Antimicrobial Peptides on Bacterial Adhesion and Biofilm Formation.
The study identified several AMR genes in E. coli and S. aureus isolates, including beta-lactamases (blaOXA-1, blaTEM-1A), chloramphenicol acetyltransferase (catA1), trimethoprim resistance gene (dfrA1), fluoroquinolone resistance gene (floR), sulfonamide resistance genes (sul1, sul2), methicillin resistance gene (mecA), beta-lactamase (blaZ-like), and tetracycline efflux pumps (tet(K), tet(M)).
MALDI-TOF MS Based Typing for Rapid Screening of Multiple Antibiotic Resistance E. coli and Virulent Non-O157 Shiga Toxin-Producing E. coli Isolated from the Slaughterhouse Settings and Beef Carcasses.
The study identified the presence of phoA and blaTEM genes in all selected E. coli isolates from beef shoulder and abattoir effluent, indicating their role in virulence and antibiotic resistance.
Combining Functional Genomics and Whole-Genome Sequencing to Detect Antibiotic Resistance Genes in Bacterial Strains Co-Occurring Simultaneously in a Brazilian Hospital.
The study identified multiple beta-lactamase genes, including blaTEM-105, blaOXA-1, blaKPC-2, blaCTX-M-15, blaCMY-111, blaOXA-10, blaCTX-M-1, blaHYDRO, and blaBLP, along with qnrS1, aadC, and ermC, which confer resistance to beta-lactam, quinolone, aminoglycoside, and macrolide/lincosamide/streptogramin B antibiotics. These genes were found in various bacterial species and were validated through functional screening.
Virulence Determinants and Antimicrobial Profiles of Pasteurella multocida Isolated from Cattle and Humans in Egypt.
The study identified multiple antimicrobial resistance genes in Pasteurella multocida isolates from cattle and humans in Egypt, including erm(Q), erm(42), mph(E), msr(E), intl1, intl2, blaCTX-M, blaCTX-M-1, and blaTEM, which confer resistance to various antibiotics such as erythromycin, azithromycin, cefotaxime, and ampicillin.
Multiresistant Bacteria Isolated from Intestinal Faeces of Farm Animals in Austria.
The study identified several AMR genes, including CTX-M-1, CTX-M-14, SHV-12, TEM-52, and VanA, in multiresistant bacteria isolated from the intestinal faeces of farm animals in Austria.
Virulence and Antimicrobial Resistance Profiles of Salmonella enterica Serovars Isolated from Chicken at Wet Markets in Dhaka, Bangladesh.
The study identified multiple antimicrobial resistance genes, including blaTEM, tetA, sul1, and strA/B, in Salmonella enterica serovars isolated from chicken at wet markets in Dhaka, Bangladesh. These genes conferred resistance to various antibiotics such as ampicillin, tetracycline, sulfamethoxazole-trimethoprim, and streptomycin.
Antimicrobial Resistance in Humans, Animals, Water and Household Environs in Rural Andean Peru: Exploring Dissemination Pathways through the One Health Lens.
The study identified ESBL genes (bla TEM, bla CTX-M-U, bla CTX-M-8, and bla CTX-M-3) in E. coli and Shigella spp. isolates from water and animal fecal samples, indicating the presence of multidrug-resistant bacteria in various environmental compartments in rural Andean Peru.
pCTX-M3-Structure, Function, and Evolution of a Multi-Resistance Conjugative Plasmid of a Broad Recipient Range.
The study characterizes the pCTX-M3 plasmid, highlighting its role in the dissemination of antibiotic resistance genes, including bla CTX-M-3, armA, aadA2, dfrA12, sul1, and bla TEM-1. These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, sulfonamides, and trimethoprim.
Serotyping and Antimicrobial Resistance Profile of Enteric Nontyphoidal Salmonella Recovered from Febrile Neutropenic Patients and Poultry in Egypt.
The study identified several antimicrobial resistance genes, including bla CTX-m, bla SHV, bla TEM, and aac (6')-Ib, in both human and poultry isolates of non-typhoidal Salmonella. These genes were found to confer resistance to various antibiotics such as cefotaxime, ampicillin, and gentamicin.
Colonization with multidrug-resistant Enterobacteriaceae among infants: an observational study in southern Sri Lanka.
The study identified several AMR genes, including bla CTX-M-15, bla TEM-1, mcr1.1, gyrA-S83L, and mph(A), which confer resistance to various antibiotics in multidrug-resistant Enterobacteriaceae isolates from infants and mothers in southern Sri Lanka.
Chlorine disinfection facilitates natural transformation through ROS-mediated oxidative stress.
The study shows that chlorine-based disinfectants can enhance the transformation of plasmid-encoded antibiotic resistance genes (ARGs) by increasing reactive oxygen species (ROS) and cell membrane permeability in Acinetobacter baylyi ADP1. The genes bla TEM-1 and tetA were experimentally validated to confer resistance to ampicillin and tetracycline, respectively.
Multidrug-resistant Klebsiella pneumoniae harboring extended spectrum β-lactamase encoding genes isolated from human septicemias.
The study identified multiple beta-lactamase genes including bla CTX-M-15, bla SHV-1, bla SHV-11, bla SHV-27, bla SHV-106, and bla TEM, along with carbapenemase genes bla KPC2/3 and bla OXA-48, contributing to multidrug resistance in Klebsiella pneumoniae isolates from human septicemias.
Multimodal Interventions to Prevent and Control Carbapenem-Resistant Enterobacteriaceae and Extended-Spectrum beta-lactamase Producer-Associated Infections at a Tertiary Care Hospital in Egypt.
The study identified several carbapenemase genes (bla KPC, bla NDM, bla VIM, bla OXA-48, bla IMP) and extended-spectrum beta-lactamase genes (bla CTX-m, bla TEM, bla SHV) in CRE and ESBL-producing isolates, highlighting the prevalence of these resistance mechanisms in a tertiary care hospital in Egypt.
atpD gene sequencing, multidrug resistance traits, virulence-determinants, and antimicrobial resistance genes of emerging XDR and MDR-Proteus mirabilis.
The study identified multiple antimicrobial resistance genes in XDR and MDR-Proteus mirabilis isolates from ducks, including blaTEM, blaOXA-1, blaCTX-M, tetA, sul1, blaNDM-1, and blaKPC. These genes confer resistance to various antibiotic classes such as penicillins, cephalosporins, tetracyclines, sulfonamides, and carbapenems.
Characterization of beta-lactam-resistant Escherichia coli from Australian fruit bats indicates anthropogenic origins.
The study identified various beta-lactam-resistant Escherichia coli strains from Australian fruit bats, highlighting the presence of multiple AMR genes such as bla TEM-1A, bla TEM-1B, bla CTX-M-27, bla NDM-5, and others, indicating anthropogenic origins of these resistant strains.
Characterization of beta-lactam-resistant Escherichia coli from Australian fruit bats indicates anthropogenic origins.
The study identified various beta-lactam-resistant Escherichia coli strains from Australian fruit bats, highlighting the presence of multiple AMR genes such as bla TEM-1A, bla TEM-1B, bla CTX-M-27, bla NDM-5, and others, indicating anthropogenic origins of these resistant strains.
Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance.
The study identifies plasmid-mediated cephalosporin resistance in Salmonella Typhi isolates from India, including bla SHV-12, bla TEM-1B, bla DHA-1, qnrB7, qnrB4, aac(6')Iaa, dfrA14, sul1, and sul2 genes. Chromosomal mutations in gyrA (S83F, D87N, S80I) and parC (S80I, E84K) contribute to fluoroquinolone resistance.
Resistance Detection and Transmission Risk Analysis of Pig-Derived Pathogenic Escherichia coli in East China.
The study identified multidrug-resistant pig-derived pathogenic Escherichia coli in East China, with high prevalence of bla CTX-M, bla TEM, and bla OXA genes conferring resistance to beta-lactam antibiotics.
Multidrug-resistant bacteria as intestinal colonizers and evolution of intestinal colonization in healthy university students in Portugal.
The study identified various AMR genes in commensal E. coli isolates from healthy university students in Portugal, including bla TEM, tetA, tetB, sul1, sul2, sul3, parC, and gyrA, indicating the presence of multidrug-resistant bacteria in the intestinal microbiota.
Genomic Insights into Drug Resistance and Virulence Platforms, CRISPR-Cas Systems and Phylogeny of Commensal E. coli from Wildlife.
The study identified various AMR genes in commensal E. coli strains from wildlife, including bla TEM-1, bla CTX-M-1, tet(A), tet(B), and several resistance gene cassettes in integrons. These genes were found to confer resistance to multiple antibiotics, highlighting the presence of AMR in wildlife E. coli populations.
Are There Effective Intervention Measures in Broiler Production against the ESBL/AmpC Producer Escherichia coli?
The study identifies several beta-lactamase genes including blaCTX-M15, blaTEM-52, blaTEM-20, blaSHV-12, blaSHV-12/TEM, blaCTX-M1, and blaCMY-2 that confer resistance to various beta-lactam antibiotics in ESBL/AmpC-producing E. coli isolates from broiler chickens.
Antibiotic Resistance and Virulence Gene Patterns Associated with Avian Pathogenic Escherichia coli (APEC) from Broiler Chickens in Qatar.
The study identifies the presence of Avian Pathogenic Escherichia coli (APEC) strains with high antibiotic resistance, particularly to ampicillin, cephalothin, ciprofloxacin, tetracycline, fosfomycin, and colistin. The blaTEM gene was detected in extended-spectrum beta-lactamase (ESBL)-producing isolates, and the mcr-1 gene was associated with colistin resistance.
Diversity of Plasmids and Genes Encoding Resistance to Extended-Spectrum beta-lactamase in Escherichia coli from Different Animal Sources.
The study identified various AMR genes and mutations in E. coli isolates from different animal sources, highlighting the presence of ESBL genes such as bla CTX-M-15, bla TEM-1B, and bla CMY-28, as well as mutations in parC and gyrA that confer resistance to fluoroquinolones.
Diversity of Plasmids and Genes Encoding Resistance to Extended-Spectrum β-Lactamase in Escherichia coli from Different Animal Sources.
The study identified various AMR genes and mutations in E. coli isolates from different animal sources, highlighting the presence of ESBL genes such as bla CTX-M-15, bla TEM-1B, and bla CMY-28, as well as mutations in parC and gyrA that confer resistance to fluoroquinolones.
Molecular Characterization of Antimicrobial Resistance and Virulence Genes of Bacterial Pathogens from Bovine and Caprine Mastitis in Northern Lebanon.
The study identified several AMR genes, including blaTEM, blaCMY-II, blaOXA, and mecA, in bacterial pathogens causing mastitis in dairy animals in Northern Lebanon.
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
Genomic analysis and phylogenetic position of the complex IncC plasmid found in the Spanish monophasic clone of Salmonella enterica serovar Typhimurium.
The study identifies various AMR genes in the IncC plasmid pUO-STmRV1, including blaTEM-1, cmlA1, aac(3)-IV, aadA1, aadA2, sul1, sul2, sul3, tet(A), dfrA12, arsR2, arsH, merRTPCADE, and silESRCBAP, which confer resistance to antibiotics and heavy metals.
Genomic surveillance of Neisseria gonorrhoeae in the Philippines, 2013-2014.
The study identified several AMR genes and mutations in Neisseria gonorrhoeae isolates from the Philippines, including bla TEM for penicillin resistance, tetM for tetracycline resistance, and various mutations in gyrA, parC, mtrR, rpsJ, penA, ponA, and porB that contribute to resistance against penicillin, ciprofloxacin, and tetracycline.
Risk factors for the development of neonatal sepsis in a neonatal intensive care unit of a tertiary care hospital of Nepal.
The study identified bla TEM and bla KPC genes as the most common ESBL and carbapenemase genes in Gram-negative bacilli causing neonatal sepsis in a Nepalese NICU.
Metabolically Active Prokaryotes and Actively Transcribed Antibiotic Resistance Genes in Sewer Systems: Implications for Public Health and Microbially Induced Corrosion.
Three antibiotic resistance genes (sul 1, bla TEM, and tet (G)) were actively transcribed in sewer systems, indicating their potential role in antibiotic resistance. These genes were detected in sewer sediment samples, suggesting their involvement in the spread of resistance in environmental settings.
The Ferric Citrate Uptake System Encoded in a Novel bla (CTX-M-3)- and bla (TEM-1)-Harboring Conjugative Plasmid Contributes to the Virulence of Escherichia coli.
The study identifies a novel conjugative plasmid pEC41 that carries the fec system, which enhances iron uptake in E. coli, contributing to its virulence. The plasmid also harbors the bla(CTX-M-3) and bla(TEM-1) genes, which confer ampicillin resistance.
Colonization with selected antibiotic resistant bacteria among a cohort of Sri Lankan university students.
The study identified bla CTX-M, bla SHV, and bla TEM as the most common genetic determinants of ESBL production in E. coli and K. pneumoniae. Additionally, mecA and pvl genes were detected in MRSA isolates.
Characterization of antibiotic resistance in Escherichia coli isolates from Black-headed gulls (Larus ridibundus) present in the city of Novi Sad, Serbia.
The study identified bla TEM-1, bla CTX-M-1, and bla CMY-2 genes in E. coli isolates from black-headed gulls, as well as mutations in gyrA and parC genes contributing to ciprofloxacin resistance.
Mistranslation can promote the exploration of alternative evolutionary trajectories in enzyme evolution.
The study demonstrates that mistranslation can influence the evolutionary trajectory of the TEM-1 beta-lactamase, leading to diverse resistance genotypes against cefotaxime.
Characterization of beta-lactamase and quinolone resistant Clostridium perfringens recovered from broiler chickens with necrotic enteritis in Bangladesh.
The study identified beta-lactamase genes (bla TEM, bla SHV, bla OXA) and quinolone resistance genes (qnrB, qnrS) in Clostridium perfringens isolates from broiler chickens with necrotic enteritis, indicating multidrug resistance.
Detection of Extended-Spectrum beta-lactamases among Acinetobacter Baumannii Isolated from Hospitals of Qazvin, Iran.
The study identified the presence of blaOXA-1, blaTEM-1, blaGES-1, blaCTX-M-15, and blaPER-1 genes in ESBL-producing Acinetobacter baumannii isolates in Qazvin, Iran. These genes were found to confer resistance to various β-lactam antibiotics.
Isolation, Antimicrobial Resistance Phenotypes, and Virulence Genes of Bordetella bronchiseptica From Pigs in China, 2018-2020.
The study identified several antimicrobial resistance genes in Bordetella bronchiseptica isolates from pigs in China, including aac(3)-IV, aac6'-Ib, rmtA, blaTEM, blaSHV, oqxB, and tetA. These genes confer resistance to various antibiotics such as aminoglycosides, beta-lactams, fluoroquinolones, and tetracyclines.
Longitudinal study on antibiotic susceptibility in commensal E. coli from geese raised in free-range production systems.
The study identified several beta-lactamase genes, including blaSHV, blaCTX-M-1, and blaTEM, in commensal E. coli from geese raised in free-range systems. These genes confer resistance to various beta-lactam antibiotics.
Carbapenem-resistant Enterobacter cloacae complex in a tertiary Hospital in Northeast China, 2010-2019.
The study identified several carbapenemase-encoding genes, including blaNDM-1, blaNDM-5, blaIMP-4, and blaKPC-2, along with various beta-lactamase genes such as TEM-1, CTX-M-15, CTX-M-3, SHV-12, and CTX-M-14, in carbapenem-resistant Enterobacter cloacae complex isolates.
Intense intestinal carriage and subsequent acquisition of multidrug-resistant enterobacteria in neonatal intensive care unit in Morocco.
The study identified the bla CTX-M-1, bla CTX-M-9, bla SHV, bla TEM, and bla OXA-48 genes as the primary resistance mechanisms in multidrug-resistant Enterobacteriaceae isolated from neonates in a Moroccan NICU.
First Detection of Human ST131-CTX-M-15-O25-B2 Clone and High-Risk Clonal Lineages of ESBL/pAmpC-Producing E. coli Isolates from Diarrheic Poultry in Tunisia.
The study identified the presence of the human pandemic ST131-CTX-M-15-O25-B2 clone and high-risk clonal lineages of ESBL/pAmpC-producing E. coli isolates from diarrheic poultry in Tunisia, highlighting the emergence of multidrug-resistant clones with various virulence determinants.
Molecular Analysis of Antimicrobial Resistance among Enterobacteriaceae Isolated from Diarrhoeic Calves in Egypt.
The study identified multiple antimicrobial resistance genes, including blaTEM, floR, dfrA1, dfrA17, aadA1, aadA2, aadA5, catB3, sat1, and blaPse1, in Enterobacteriaceae isolates from diarrhoeic calves in Egypt. These genes confer resistance to various antibiotics such as ampicillin, tetracycline, chloramphenicol, and others.
Antimicrobial Resistance Profiling of Biofilm Forming Non Typhoidal Salmonella enterica Isolates from Poultry and Its Associated Food Products from Pakistan.
The study identified several AMR genes in Salmonella enterica isolates from poultry and food products in Pakistan, including bla TEM-1, bla OxA-1, bla PSE-1, bla CMY-2, ampC, and the virulence gene sopE. These genes were associated with resistance to multiple antibiotics, highlighting the public health concerns related to AMR in Salmonella.
The Beta-Lactam Resistome Expressed by Aerobic and Anaerobic Bacteria Isolated from Human Feces of Healthy Donors.
The study identifies several beta-lactamase genes, including blaTEM, blaSHV, blaKPC, blaCMY, blaBIL, blaCFX, and blaP, in aerobic and anaerobic bacteria isolated from the feces of healthy donors, highlighting the human gut as a reservoir of beta-lactam resistance.
Antibiotic Resistant and Biofilm-Associated Escherichia coli Isolates from Diarrheic and Healthy Dogs.
The study identified several AMR genes in E. coli isolates from healthy and diarrheic dogs, including blaTEM-1, qnrB, qnrS, aac(6')-Ib-cr, tetA, tetB, dfrA, sul1, sul2, int1, and tn3. These genes confer resistance to various antibiotics such as ampicillin, ciprofloxacin, tetracycline, trimethoprim, and sulfonamide.
ESBL/AmpC-Producing Escherichia coli in Wild Boar: Epidemiology and Risk Factors.
The study identified bla CTX-M, bla TEM, bla CMY, and bla SHV genes in ESBL/AmpC-producing E. coli from wild boar, highlighting the role of wild boar as a potential reservoir of antimicrobial resistance.
ESBL/AmpC-Producing Escherichia coli in Wild Boar: Epidemiology and Risk Factors.
ESBL/AmpC-Producing Escherichia coli in Wild Boar: Epidemiology and Risk Factors.
Antibiotic Susceptibility, Virulome, and Clinical Outcomes in European Infants with Bloodstream Infections Caused by Enterobacterales.
The study identified various AMR genes, including blaTEM, blaSHV, blaCTX-M, blaVIM-12, and mcr-9, in Enterobacterales isolates from European infants with bloodstream infections. These genes conferred resistance to multiple antibiotics, highlighting the complexity of AMR in this context.
Antimicrobial Resistance and Genomic Characterization of Two mcr-1-Harboring Foodborne Salmonella Isolates Recovered in China, 2016.
Two mcr-1-harboring Salmonella isolates, CFSA231 and CFSA629, were identified. The mcr-1 gene was found on an IncX4 plasmid in CFSA231 and on an IncHI2A/IncHI2 plasmid in CFSA629. A novel mcr-1 variant, mcr-1.19, was identified in CFSA629.
High prevalence of bla(CTX-M) and bla(SHV) among ESBL producing E. coli isolates from beef cattle in China's Sichuan-Chongqing Circle.
The study identified a high prevalence of bla(CTX-M) and bla(SHV) genes among ESBL-producing E. coli isolates from beef cattle in the Sichuan-Chongqing Circle of China. These genes confer resistance to various beta-lactam antibiotics.
Antimicrobial resistance patterns among different Escherichia coli isolates in the Kingdom of Saudi Arabia.
The study identified several beta-lactamase genes (blaCTX-M-1group, blaCTX-M-15, blaCTX-M-2group, blaOXA-47, blaTEM, blaCMY-2) and the quinolone resistance gene qnrS in E. coli isolates from various sources in Saudi Arabia. These genes contribute to resistance against multiple antibiotics, highlighting the need for improved antimicrobial stewardship.
Characterization of resistance mechanisms of Enterobacter cloacae Complex co-resistant to carbapenem and colistin.
The study identified blaKPC-2, blaNDM-1, mcr-4.3, ecr, ampC, blaCTX-M-14, blaCTX-M-9, blaSHV, and blaTEM as genes contributing to carbapenem and colistin resistance in Enterobacter cloacae Complex strains.
WGS based analysis of acquired antimicrobial resistance in human and non-human Acinetobacter baumannii isolates from a German perspective.
The study identified multiple acquired antimicrobial resistance (AMR) genes in 189 German Acinetobacter baumannii strains, including blaADC.25, blaOXA-23, blaOXA-66, ant(3")-IIa, sul2, tet.B, mph.E, msr.E, and blaTEM, which confer resistance to various antibiotics such as aminoglycosides, cephalosporins, carbapenems, sulfonamides, tetracyclines, and macrolides.
Foodborne Pathogenic Vibrios: Antimicrobial Resistance.
The paper discusses the presence of various antibiotic resistance genes in Vibrio species, including strB, sul2, tetA, blaTEM, qnrA, ermB, floR, aac(3)-IIa, blaNDM-1, blaCMY, blaP1, catB3, and others, which confer resistance to antibiotics such as streptomycin, sulfamethoxazole, tetracycline, ampicillin, fluoroquinolones, erythromycin, florfenicol, gentamicin, carbapenems, chloramphenicol, and trimethoprim.
Antimicrobial Resistance Mechanisms, Multilocus Sequence Typing, and NG-STAR Sequence Types of Diverse Neisseria gonorrhoeae Isolates in KwaZulu-Natal, South Africa.
The study identified multiple AMR genes and mutations in Neisseria gonorrhoeae isolates from KwaZulu-Natal, South Africa, including blaTEM, penA_ins346D, ponA_L421P, mtrR_G45D, porB1b_G120K, porB1b_A121N, mtrR_disrupted, tetM, rpsJ_V57M, gyrA_S91F, gyrA_D95G, gyrA_D95A, parC_D86N, S87N, and S87I, which confer resistance to penicillin, tetracycline, and ciprofloxacin.
QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics.
QPX7728 is a novel β-lactamase inhibitor with broad-spectrum activity against serine and metallo-β-lactamases, including Class A, C, D, and B enzymes. It effectively inhibits clinically relevant β-lactamases such as KPC-2, CTX-M-15, SHV-12, TEM-43, OXA-48, OXA-23, NDM-1, and VIM-1.
QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics.
QPX7728 is a novel beta-lactamase inhibitor with broad-spectrum activity against serine and metallo-beta-lactamases, including Class A, C, D, and B enzymes. It effectively inhibits clinically relevant beta-lactamases such as KPC-2, CTX-M-15, SHV-12, TEM-43, OXA-48, OXA-23, NDM-1, and VIM-1.
Molecular detection of Extended-Spectrum beta-lactamases (ESBLs) and biofilm formation in uropathogen Klebsiella pneumoniae in Iran.
The study identified bla TEM and bla VEB genes as prevalent ESBLs in K. pneumoniae isolates, contributing to resistance against cefotaxime and tetracycline.
Genetic characterization of extended-spectrum beta-lactamase- and carbapenemase-producing Escherichia coli isolated from Egyptian hospitals and environments.
The study identified several beta-lactamase genes, including blaTEM, blaCTX-M15, blaSHV, blaOXA-48, and blaIMP, which confer resistance to various β-lactam antibiotics in Escherichia coli isolates from Egyptian hospitals and environments.
Genomic evolution of antimicrobial resistance in Escherichia coli.
The study identified several AMR genes in Escherichia coli isolates from different animal sources in Europe, including blaTEM-1B, qnrB19, qnrS1, sul1, sul2, sul3, tet(A), aadA1, and aph(6)-Id. These genes were associated with resistance to beta-lactams, fluoroquinolones, sulfonamides, tetracyclines, and aminoglycosides.
Detection of bla(TEM), bla(CTX-M), bla(CMY), and bla(SHV) Genes Among Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolated from Migratory Birds Travelling to Bangladesh.
The study identified bla(TEM), bla(CTX-M), bla(CMY), and bla(SHV) genes in extended-spectrum beta-lactamase-producing Escherichia coli isolated from migratory birds in Bangladesh, highlighting the role of migratory birds as potential carriers of antibiotic resistance genes.
Plasmid analysis of NDM metallo-β-lactamase-producing Enterobacterales isolated in Vietnam.
The study characterizes bla NDM-1 and bla NDM-4 carrying plasmids in Enterobacterales isolates from Vietnam, highlighting their role in carbapenem resistance and horizontal gene transfer.
Evidence of potentially unrelated AmpC beta-lactamase producing Enterobacteriaceae from cattle, cattle products and hospital environments commonly harboring the blaACC resistance determinant.
The study identified blaACC, blaCIT, blaFOX, and blaDHA genes as prevalent AmpC beta-lactamase resistance determinants in Enterobacteriaceae from cattle, cattle products, and hospital environments.
Prevalence and mechanisms of antibiotic resistance in Escherichia coli isolated from mastitic dairy cattle in Canada.
The study identified several AMR genes in E. coli isolates from bovine mastitis, including beta-lactamases (blaTEM-1, blaCARB-3, blaCMY-59), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aadA2), and multidrug efflux pump genes (acrA, acrB, acrD, tolC, baeR, emrA, emrB).
First Description of Various Bacteria Resistant to Heavy Metals and Antibiotics Isolated from Polluted Sites in Tunisia.
The study identified the presence of blaTEM, blaSHV, silE, cusA, and merA genes in environmental bacteria isolated from polluted sites in Tunisia, indicating resistance to antibiotics and heavy metals.
The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries.
The study identified multiple AMR genes and mutations in invasive non-typhoidal Salmonella isolates from sub-Saharan Africa, highlighting the prevalence of multidrug resistance.
Genome-Scale Metabolic Models and Machine Learning Reveal Genetic Determinants of Antibiotic Resistance in Escherichia coli and Unravel the Underlying Metabolic Adaptation Mechanisms.
The study identifies 20 top-ranked genetic determinants associated with antibiotic resistance in E. coli, including genes involved in cell wall metabolism, energy metabolism, and iron metabolism, using a combination of machine learning and genome-scale metabolic models.
Genomic Epidemiology of Multidrug-Resistant Nontyphoidal Salmonella in Young Children Hospitalized for Gastroenteritis.
Emergence and Clonal Spread of CTX-M-65-Producing Escherichia coli From Retail Meat in Portugal.
The study identifies the blaCTX-M-65 gene in four multidrug-resistant Escherichia coli isolates from retail meat in Portugal, highlighting its chromosomal location and association with various resistance mechanisms.
Molecular Characterization of Cephalosporin and Fluoroquinolone Resistant Salmonella Choleraesuis Isolated from Patients with Systemic Salmonellosis in Thailand.
The study identified multiple ESBL genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla CMY-2, bla ACC-1, and bla TEM-1, along with PMQR genes such as qnrA, qnrB, qnrS, and aac(6′)-Ib-cr, contributing to resistance against cephalosporins and fluoroquinolones in Salmonella Choleraesuis isolates from Thailand.
Prevalence and Characterization of Extended-Spectrum β-Lactamase-Producing Antibiotic-Resistant Escherichia coli and Klebsiella pneumoniae in Ready-to-Eat Street Foods.
The study identified the presence of extended-spectrum beta-lactamase (ESBL)-producing antibiotic-resistant Escherichia coli and Klebsiella pneumoniae in ready-to-eat street foods, highlighting the prevalence of bla TEM, bla CTX, bla SHV, and bla NDM genes, which confer resistance to multiple antibiotics.
Analysis of Wastewater Reveals the Spread of Diverse Extended-Spectrum beta-lactamase-Producing E. coli Strains in uMgungundlovu District, South Africa.
The study identified CTX-M, SHV, and TEM-type ESBL genes in E. coli isolates from wastewater treatment plants in South Africa, highlighting the prevalence of extended-spectrum beta-lactamase-producing E. coli strains.
High Prevalence of ESBL and Plasmid-Mediated Quinolone Resistance Genes in Salmonella enterica Isolated from Retail Meats and Slaughterhouses in Egypt.
The study identified various ESBL and PMQR genes in Salmonella enterica isolates from retail meats and slaughterhouses in Egypt, highlighting their high prevalence and potential public health implications.
High Prevalence of ESBL and Plasmid-Mediated Quinolone Resistance Genes in Salmonella enterica Isolated from Retail Meats and Slaughterhouses in Egypt.
The study identified various ESBL and PMQR genes in Salmonella enterica isolates from retail meats and slaughterhouses in Egypt, highlighting their high prevalence and potential public health implications.
Antibiotic-resistant bacteria, antibiotic resistance genes, and antibiotic residues in wastewater from a poultry slaughterhouse after conventional and advanced treatments.
The study identified several antibiotic resistance genes (ARGs) in wastewater from a poultry slaughterhouse, including bla TEM, bla CTX-M-1, bla SHV-12, mcr-1, ermB, sul1, tetM, bla OXA-48, bla CMY-2, and vanA. These genes were found to confer resistance to various antibiotics such as beta-lactams, macrolides, sulfonamides, tetracyclines, carbapenems, and glycopeptides.
Antibiotic-resistant bacteria, antibiotic resistance genes, and antibiotic residues in wastewater from a poultry slaughterhouse after conventional and advanced treatments.
The study identified several antibiotic resistance genes (ARGs) in wastewater from a poultry slaughterhouse, including bla TEM, bla CTX-M-1, bla SHV-12, mcr-1, ermB, sul1, tetM, bla OXA-48, bla CMY-2, and vanA. These genes were found to confer resistance to various antibiotics such as beta-lactams, macrolides, sulfonamides, tetracyclines, carbapenems, and glycopeptides.
Antibiotic-resistant bacteria, antibiotic resistance genes, and antibiotic residues in wastewater from a poultry slaughterhouse after conventional and advanced treatments.
The study identified several antibiotic resistance genes (ARGs) in wastewater from a poultry slaughterhouse, including bla TEM, bla CTX-M-1, bla SHV-12, mcr-1, ermB, sul1, tetM, bla OXA-48, bla CMY-2, and vanA. These genes were found to confer resistance to various antibiotics such as beta-lactams, macrolides, sulfonamides, tetracyclines, carbapenems, and glycopeptides.
Molecular detection of vancomycin and methicillin resistance in Staphylococcus aureus isolated from food processing environments.
The study identified methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant S. aureus (VRSA) in food processing environments in Bangladesh, highlighting the presence of resistance genes mecA, vanC, and blaTEM.
Antimicrobial resistance profiles and genetic basis of resistance among non-fastidious Gram-negative bacteria recovered from ready-to-eat foods in Kibera informal housing in Nairobi, Kenya.
The study identified several beta-lactamase genes including bla TEM, bla CTX-M, bla SHV, and bla OXA-1, along with class 1 and 2 integrons, contributing to antimicrobial resistance in Gram-negative bacteria from ready-to-eat foods in Kibera, Kenya.
Higher Prevalence of Extended Spectrum β-Lactamase Producing Uropathogenic Escherichia coli Among Patients with Diabetes from a Tertiary Care Hospital of Kathmandu, Nepal.
The study identified bla TEM and bla CTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) production in uropathogenic Escherichia coli isolates from diabetic and non-diabetic patients in Nepal. These genes were found to confer resistance to multiple beta-lactam antibiotics.
High β-Lactam and Quinolone Resistance of Enterobacteriaceae from the Respiratory Tract of Sheep and Goat with Respiratory Disease.
The study identified high β-lactam and quinolone resistance in Enterobacteriaceae from sheep and a goat with respiratory disease, highlighting the presence of bla TEM, bla SHV, bla CTX-M, and qnrS genes.
Molecular Epidemiology of Escherichia coli Clinical Isolates from Central Panama.
The study identified the presence of the pandemic E. coli clone ST43/ST131 harboring CTX-M-15 in Central Panama, highlighting the emergence of multidrug-resistant E. coli strains.
Genetic Background and Antibiotic Resistance Profiles of K. pneumoniae NDM-1 Strains Isolated from UTI, ABU, and the GI Tract, from One Hospital in Poland, in Relation to Strains Nationally and Worldwide.
The study identified eleven antimicrobial resistance genes in K. pneumoniae NDM-1 strains, including bla NDM-1, bla CTX-M-15, bla OXA-1, and others, contributing to multidrug resistance. The strains exhibited resistance to various antibiotics, including carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides.
Antimicrobial Resistance of Non-Typhoid Salmonella in Meat and Meat Products.
The study highlights the prevalence of antimicrobial resistance in non-typhoid Salmonella isolates from meat and meat products, emphasizing the resistance patterns to antibiotics such as tetracycline, sulfonamides, ampicillin, and streptomycin. It identifies Enteritidis and Typhimurium as the most common serovars with significant resistance levels.
Genetic Diversity of Leuconostoc mesenteroides Isolates from Traditional Montenegrin Brine Cheese.
The study identified antimicrobial resistance genes in Leuconostoc mesenteroides isolates from Montenegrin brine cheese, including a 23S rRNA mutation conferring resistance to erythromycin and clindamycin, and a partial blaTEM gene associated with beta-lactam resistance.
The Pheno- and Genotypic Characterization of Porcine Escherichia coli Isolates.
The study identified bla TEM-1, bla CTX-M-1, and mcr-1.1 as the primary AMR genes in porcine E. coli isolates, along with mutations in gyrA, parC, and parE contributing to fluoroquinolone resistance.
Preliminary Results on the Prevalence of Salmonella spp. in Marine Animals Stranded in Sicilian Coasts: Antibiotic Susceptibility Profile and ARGs Detection in the Isolated Strains.
Three Salmonella spp. strains were isolated from marine animals in Sicily, showing resistance to ampicillin, tetracycline, and sulfamethoxazole. All strains harbored multiple antibiotic resistance genes, including blaTEM, blaOXA, tet(A), tet(D), tet(E), sulI, and sulII.
Antibiotic Resistance and Virulence Profiles of Escherichia coli Strains Isolated from Wild Birds in Poland.
The study identified several AMR genes in E. coli strains isolated from wild birds in Poland, including blaTEM, aphA1, sul2, and tetA, which confer resistance to ampicillin, kanamycin, trimethoprim/sulfamethoxazole, and tetracycline, respectively.
Genetic Features of Plasmid- and Chromosome-Mediated mcr-1 in Escherichia coli Isolates From Animal Organs With Lesions.
The study characterizes the mcr-1 gene and various other resistance genes in Escherichia coli isolates from animal organs with lesions, highlighting their multidrug resistance profiles and the genetic features of plasmids carrying these genes.
Genomic Diversity and Antimicrobial Resistance of Haemophilus Colonizing the Airways of Young Children with Cystic Fibrosis.
Artificial sweeteners stimulate horizontal transfer of extracellular antibiotic resistance genes through natural transformation.
Artificial sweeteners enhance the horizontal transfer of extracellular antibiotic resistance genes (ARGs) through natural transformation in Acinetobacter baylyi ADP1, Bacillus subtilis, and mice fecal microbiome. The study identifies that the plasmid pWH1266, carrying blaTEM-1 and tetA, is efficiently taken up by competent cells, leading to increased resistance to ampicillin and tetracycline.
Occurrence of bla (CTX-MGp1) and bla (CTX-MGp26) in third generation cephalosporin-resistant and carbapenem- resistant bacterial isolates from southwest region of Saudi Arabia-a preliminary study
The study identified bla CTX-M Group1 and bla CTX-M Group26 as prevalent in third-generation cephalosporin-resistant and carbapenem-resistant bacterial isolates from the Jizan region of Saudi Arabia. bla CTX-M was the most common gene, followed by bla SHV and bla TEM.
Antibiotic Breakdown by Susceptible Bacteria Enhances the Establishment of β-Lactam Resistant Mutants.
The study identifies the TEM-1 beta-lactamase as a gene that contributes to cefotaxime resistance in E. coli, showing that susceptible cells expressing this enzyme can enhance the establishment of β-lactam-resistant mutants by breaking down the antibiotic.
Antimicrobial Resistance and Whole-Genome Characterisation of High-Level Ciprofloxacin-Resistant Salmonella Enterica Serovar Kentucky ST 198 Strains Isolated from Human in Poland.
The study identified several AMR genes and mutations in high-level ciprofloxacin-resistant Salmonella Enterica serovar Kentucky ST198 strains isolated from humans in Poland, including blaTEM-1B, qnrS1, aac(3)-Id, aac(3)-IId, aac(6')-Iaa, aac(6')-Iid, aph(3")-Ib, aph(3")-Id, aadA1, sul1, dfrA1, and tetA, along with mutations in gyrA and parC that confer resistance to quinolones and beta-lactams.
Wrist abscess due to drug-resistant Pasteurella multocida.
The study reports the first documented case of a human Pasteurella multocida infection with resistance to amoxicillin-clavulanic acid, highlighting the potential emergence of drug-resistant Pasteurella spp. and the importance of monitoring antimicrobial resistance patterns.
Prevalence and characterization of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolated from raw vegetables retailed in Southern Thailand.
The study identified the prevalence of ESBL-producing E. coli and K. pneumoniae in raw vegetables in Southern Thailand, highlighting the presence of bla SHV as the most common ESBL-encoding gene, along with bla TEM, bla CTX-M1, and bla CTX-M9.
Discerning the Antimicrobial Resistance, Virulence, and Phylogenetic Relatedness of Salmonella Isolates Across the Human, Poultry, and Food Materials Sources in Malaysia.
The study identified several AMR genes in Salmonella Enteritidis isolates from Malaysia, including aac(6')-ly, blaCMY-2, blaTEM-1, blaTEM-33, blaTEM-4, dfrA14, dfrA15, floR, qnrS1, qnrD1, sul1, sul2, strA, strB, tetA, and tetC. These genes conferred resistance to various antibiotics such as gentamicin, ampicillin, chloramphenicol, ciprofloxacin, sulfamethazine/trimethoprim, and tetracycline.
Discerning the Antimicrobial Resistance, Virulence, and Phylogenetic Relatedness of Salmonella Isolates Across the Human, Poultry, and Food Materials Sources in Malaysia.
The study identified several AMR genes in Salmonella Enteritidis isolates from Malaysia, including aac(6')-ly, blaCMY-2, blaTEM-1, blaTEM-33, blaTEM-4, dfrA14, dfrA15, floR, qnrS1, qnrD1, sul1, sul2, strA, strB, tetA, and tetC. These genes conferred resistance to various antibiotics such as gentamicin, ampicillin, chloramphenicol, ciprofloxacin, sulfamethazine/trimethoprim, and tetracycline.
Discerning the Antimicrobial Resistance, Virulence, and Phylogenetic Relatedness of Salmonella Isolates Across the Human, Poultry, and Food Materials Sources in Malaysia.
The study identified several AMR genes in Salmonella Enteritidis isolates from Malaysia, including aac(6')-ly, blaCMY-2, blaTEM-1, blaTEM-33, blaTEM-4, dfrA14, dfrA15, floR, qnrS1, qnrD1, sul1, sul2, strA, strB, tetA, and tetC. These genes conferred resistance to various antibiotics such as gentamicin, ampicillin, chloramphenicol, ciprofloxacin, sulfamethazine/trimethoprim, and tetracycline.
Comparative analysis of genetic characterization of β-lactam-resistant Escherichia coli from bulk tank milk in Korea.
The study identified blaOXA-1 and blaTEM-1 as the dominant β-lactamase genes in β-lactam-resistant E. coli isolates from bulk tank milk in Korea. Additionally, aac(6')-Ib, aac(3)-II, and aph(3'')-Ib were found to confer resistance to aminoglycosides.
The Epidemiology, Virulence and Antimicrobial Resistance of Invasive Klebsiella pneumoniae at a Children's Medical Center in Eastern China.
The study identified multiple beta-lactam resistance genes, including bla SHV-11, bla FOX-1, bla ACT-1, bla CTX-M-14, bla TEM-1, bla VIM-1, bla NDM-1, bla KPC-2, and bla OXA-1, in invasive Klebsiella pneumoniae isolates. Additionally, hypervirulence genes such as iroB, p rmpA, mrkD, wabG, Uge, fimH, and ycfM were prevalent.
Genetic relatedness in extended-spectrum beta-lactamase-producing Escherichia coli from clinical isolates using enterobacterial repetitive intergenic consensus polymerase chain reaction.
The study identified blaTEM, blaSHV, blaCTX-M, and blaOXA as the primary ESBL genes in E. coli isolates, with blaTEM being the most prevalent. These genes conferred resistance to various beta-lactam antibiotics.
Infective endocarditis caused by Enterobacteriaceae: phenotypic and molecular characterization of Escherichia coli and Klebsiella pneumoniae in Rio de Janeiro, Brazil.
The study identified several AMR genes in E. coli and K. pneumoniae isolates causing infective endocarditis, including genes conferring resistance to beta-lactams, aminoglycosides, sulfonamides, trimethoprim, fosfomycin, and fluoroquinolones. These genes were detected through molecular analysis and resistance profiling.
Prevalence, antibiotic susceptibility, and presence of drug resistance genes in Aeromonas spp. isolated from freshwater fish in Kelantan and Terengganu states, Malaysia.
The study identified multiple antibiotic resistance genes in Aeromonas spp. isolated from freshwater fish in Malaysia, including blaTEM, blaSHV, sul1, aadA, strA-strB, tetA, and tetE, which confer resistance to ampicillin, sulfamethoxazole, streptomycin, and tetracycline.
Molecular Characterization of Antibiotic Resistance Associated with TEM and CTX-M ESBL in Uropathogenic E. coli Strains Isolated from Outpatients.
The study identified blaCTX-M and blaTEM genes in uropathogenic E. coli strains, which confer resistance to ceftazidime, ceftriaxone, and cefotaxime.
Occurrence of Colibacillosis in Broilers and Its Relationship With Avian Pathogenic Escherichia coli (APEC) Population Structure and Molecular Characteristics.
The study identified multiple antimicrobial resistance genes in Avian Pathogenic Escherichia coli (APEC) isolates, including beta-lactamases (blaCMY-2, blaSHV-12, blaTEM-52, blaCTX-M-1), aminoglycoside resistance genes (aac(3)-IV, aadA, strA, strB, aph(3')-Ib), sulfonamide resistance gene (sul1), tetracycline resistance genes (tet(A), tet(B)), trimethoprim resistance gene (dfrA), quinolone resistance genes (qnrS1, qnrS2, qnrB19), macrolide resistance genes (mph(A), mph(B)), and chloramphenicol resistance gene (catA1).
Assessing the Bacterial Community Composition of Bivalve Mollusks Collected in Aquaculture Farms and Respective Susceptibility to Antibiotics.
The study identified qnrA, qnrB, oqxAB, and blaTEM-1 genes in various bacterial isolates from bivalve mollusks, indicating the presence of plasmid-mediated quinolone resistance and beta-lactam resistance mechanisms.
Antimicrobial Resistance and Comparative Genome Analysis of Klebsiella pneumoniae Strains Isolated in Egypt.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant K. pneumoniae strain KPE16, including bla NDM-1, bla CTX-M-15, and various aminoglycoside, sulfonamide, and tetracycline resistance genes. Additionally, chromosomal mutations in ompK36, ompK37, and acrR contribute to resistance.
Antimicrobial Resistance Patterns and Risk Factors Associated with Salmonella spp. Isolates from Poultry Farms in the East Coast of Peninsular Malaysia: A Cross-Sectional Study.
The study identified multiple antimicrobial resistance genes in Salmonella spp. isolates from poultry farms in Malaysia, including blaTEM, tet(A), tet(B), catA1, cat2, floR, sul1, and sul2, which confer resistance to beta-lactams, tetracyclines, chloramphenicol, and sulfonamides.
Detection of CTX-M-15 Extended-Spectrum beta-lactamases Producing Escherichia coli Isolates from Colostrum and Faeces of Newborn Dairy Calves in China.
The study reports the detection of CTX-M-15 and TEM-171 beta-lactamase genes in multidrug-resistant Escherichia coli isolates from colostrum and faeces of newborn dairy calves in China, highlighting the potential for horizontal gene transfer via the IncHI2 plasmid.
Characterization of TEM-1 Mutants for Ampicillin Resistance
The study characterizes TEM-1 mutants and their resistance to ampicillin through experimental validation.
Isolation of Ciprofloxacin and Ceftazidime-Resistant Enterobacterales From Vegetables and River Water Is Strongly Associated With the Season and the Sample Type.
The study identified mcr-1, bla CTX-M, bla SHV, and bla TEM genes in Enterobacterales isolates from vegetables and river water, indicating resistance to colistin and various beta-lactam antibiotics.
Genotypic and Phenotypic Characterization of Antimicrobial Resistance Profiles in Non-typhoidal Salmonella enterica Strains Isolated From Cambodian Informal Markets.
The study identified 17 unique AMR genes in 53% of the 81 S. enterica isolates, including genes encoding resistance to tetracycline, beta-lactam, sulfonamide, quinolone, aminoglycoside, phenicol, and trimethoprim.
Emergence of mcr-1-Harboring Salmonella enterica Serovar Sinstorf Type ST155 Isolated From Patients With Diarrhea in Jiangsu, China.
The study identifies mcr-1 as a colistin resistance gene in Salmonella enterica serovar Sinstorf, along with qnrS1, aac(6')-Ib-cr4, bla CTX-M-14, and bla CTX-M-55 contributing to quinolone and beta-lactam resistance. Mutations in gyrA and parC are linked to ciprofloxacin resistance.
IS1294 Reorganizes Plasmids in a Multidrug-Resistant Escherichia coli Strain.
The study identifies and characterizes various AMR genes, including blaCTX-M-55, rmtB, oqxAB, blaTEM-1b, floR, tet(A), strA, strB, sul1, sul2, aac(3)-IId, aadA2, dfrA12, and aph(3′)-IIa, in a multidrug-resistant E. coli strain. These genes contribute to resistance against multiple antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, tetracyclines, sulfonamides, and trimethoprim.
Isolation of Salmonella spp. from black spiny-tailed iguana (Ctenosaura similis) meat commercialised in markets of León city, Nicaragua.
The study identified the presence of Salmonella spp. in meat from black spiny-tailed iguanas, with a focus on the detection of extended-spectrum beta-lactamase (ESBL) genes, particularly blaSHV, blaTEM, and blaCTX-M, which conferred resistance to amoxicillin/clavulanic acid and cephalexin.
Biological Mitigation of Antibiotic Resistance Gene Dissemination by Antioxidant-Producing Microorganisms in Activated Sludge Systems.
The study demonstrates that antioxidant-producing microorganisms, such as Deinococcus radiodurans R1 and Rhodotorula sp., can mitigate the dissemination of antibiotic resistance genes (ARGs) in activated sludge systems by reducing the persistence of plasmid RP4 and the enrichment of sul1 and intl1. These microorganisms also decrease the diversity of ARG hosts and limit the conjugative transfer of ARGs.
Antibiotic resistance in the pathogenic foodborne bacteria isolated from raw kebab and hamburger: phenotypic and genotypic study.
The study identified several antibiotic resistance genes, including blaTEM, blaSHV, blaZ, and mecA, in various foodborne pathogens isolated from raw kebab and hamburger samples. These genes were found to confer resistance to multiple antibiotics, highlighting the presence of multidrug-resistant bacteria in these food products.
Molecular Epidemiological Analysis of ST11-K64 Extensively Drug-Resistant Klebsiella pneumoniae Infections Outbreak in Intensive Care and Neurosurgery Units Based on Whole-Genome Sequencing.
The study identified multiple AMR genes in ST11-K64 XDRKp strains, including beta-lactamases, aminoglycoside resistance genes, and efflux pumps, contributing to extensive drug resistance.
Semirapid Detection of Piperacillin/Tazobactam Resistance and Extended-Spectrum Resistance to β-Lactams/β-Lactamase Inhibitors in Clinical Isolates of Escherichia coli.
The study identified bla TEM, bla SHV, and bla OXA-1 genes as the primary contributors to piperacillin/tazobactam resistance and extended-spectrum resistance to β-lactams/β-lactamase inhibitors in E. coli isolates.
Use of Molecular Methods To Detect Shigella and Infer Phenotypic Resistance in a Shigella Treatment Study.
The study identified several AMR genes including ermB, mphA, blaTEM, blaCTX-M1, blaDHA, blaOXA-1, dfrA, and sul in Shigella isolates. Mutations in gyrA (83L) and parC (80I) were associated with ciprofloxacin resistance.
Genomic Analysis of Ciprofloxacin-Resistant Salmonella enterica Serovar Kentucky ST198 From Spanish Hospitals.
The study identified several AMR genes and mutations associated with ciprofloxacin resistance in Salmonella enterica serovar Kentucky ST198 isolates from Spanish hospitals. Key findings include the presence of blaTEM-1B, aacA5, aadA7, sul1, tet(A), catA1, and aac(6′)-Ib genes, along with mutations in gyrA (Ser83Phe) and parC (Thr57Ser, Ser80Ile).
Sequence Analyses and Phenotypic Characterization Revealed Multidrug Resistant Gene Insertions in the Genomic Region Encompassing Phase 2 Flagellin Encoding fljAB Genes in Monophasic Variant Salmonella enterica Serovar 4,5,12:i:- Isolates From Various Sources in Thailand.
The study identified multiple multidrug resistance genes, including blaTEM-1B, strA, strB, sul2, and tetB, in Salmonella enterica serovar 4,5,12:i:- isolates from Thailand, which contribute to resistance against ampicillin, streptomycin, sulfonamides, and tetracycline.
Virulence, Antimicrobial Resistance and Biofilm Production of Escherichia coli Isolates from Healthy Broiler Chickens in Western Algeria.
The study identified the presence of bla TEM, bla CTX-M−1, and bla SHV genes in E. coli isolates from healthy broiler chickens in Western Algeria, indicating the spread of antimicrobial-resistant E. coli strains.
Extended-Spectrum-β-Lactamase- and AmpC-Producing Escherichia coli in Domestic Dogs: Spread, Characterisation and Associated Risk Factors.
The study identified bla CTX-M, bla TEM, bla CMY, and bla SHV as the primary AMR genes in ESBL/AmpC-producing E. coli from domestic dogs, with bla CTX-M being the most prevalent. These genes were associated with resistance to various cephalosporins and other beta-lactam antibiotics.
Identification of Three Novel PmGRI1 Genomic Resistance Islands and One Multidrug Resistant Hybrid Structure of Tn7-like Transposon and PmGRI1 in Proteus mirabilis.
The study identifies three novel variants of PmGRI1 and a hybrid structure combining Tn7-like transposon and PmGRI1 in Proteus mirabilis, highlighting their role in carrying multiple antibiotic resistance genes.
Investigation of the Genes Involved in the Outbreaks of Escherichia coli and Salmonella spp. in the United States.
The study identified several antimicrobial resistance genes in E. coli and Salmonella spp., including aadA1, aph(3"-Ib, aph(6)-Id, blaTEM-1, sul2, tet(A), and tet(B) in E. coli, and arsA, arsB, arsC, iroB, and iroC in Salmonella spp. Additionally, virulence genes such as epeA, stxA2d, stxB2c, subA, and subB were found to be unique to outbreak E. coli.
AMaLa: Analysis of Directed Evolution Experiments via Annealed Mutational Approximated Landscape.
The study presents AMaLa, a method to infer fitness landscapes from Directed Evolution experiments. It characterizes the resistance mechanisms of beta-lactamase (TEM-1, PSE-1) and acetyltransferase (AAC6) through computational and experimental validation.
Can Human Handling Increase the Presence of Multidrug Resistance (MDR) in Salmonella spp. Isolated from Food Sources?
The study identified several AMR genes in MDR Salmonella strains, including bla TEM, bla CTXM, bla OXA, sul II, tet (A), and tet (B). These genes conferred resistance to various antibiotics such as ampicillin, cefotaxime, ceftazidime, sulfamethoxazole, trimethoprim, tetracycline, and tigecycline.
Molecular Epidemiology, Antimicrobial Surveillance, and PK/PD Analysis to Guide the Treatment of Neisseria gonorrhoeae Infections.
The study identified several AMR genes and mutations in N. gonorrhoeae isolates, including blaTEM-1B, tet(M), rpsJ, and various mutations in mtrR, gyrA, parC, porB, and penA. These findings highlight the resistance mechanisms to penicillin, tetracycline, ciprofloxacin, and azithromycin.
Biofilm Formation of Clinical Klebsiella pneumoniae Strains Isolated from Tracheostomy Tubes and Their Association with Antimicrobial Resistance, Virulence and Genetic Diversity.
The study identified ESβL genes (bla SHV, bla TEM, and bla CTX-M group 1 and 9) in K. pneumoniae isolates from tracheostomy tubes, which conferred resistance to ceftazidime and cefotaxime.
Comparative genome analysis of colistin-resistant OXA-48-producing Klebsiella pneumoniae clinical strains isolated from two Iranian hospitals.
The study identifies multiple AMR genes, including blaOXA-48, blaNDM-1, blaCTX-M-15, blaTEM-1, and blaSHV, along with mutations in mgrB, pmrA, pmrB, phoQ, ramA, and crrB contributing to colistin resistance in K. pneumoniae strains.
Transmission Dynamics of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 Strains Carrying Capsular Loci KL64 and rmpA/rmpA2 Genes.
The study identified multiple AMR genes and mutations in ST11-KL64 CRKP isolates, including bla KPC-2, rmtB, catA2, fosA, qnrS1, sul2, tet(A), aadA2, dfrA14, bla CTX-M-65, bla SHV-12, bla TEM-1B, iucABCD, iutA, rmpA2, and mutations in GyrA (S83I, D87G) and ParC (S80I).
Antibiotic resistance genes in layer farms and their correlation with environmental samples.
The study identified and quantified 13 antibiotic resistance genes (ARGs) in layer manure, layer manure fertilizer, and soil samples from Guangdong Province, highlighting the high prevalence and abundance of these genes, particularly ermB, tetA, and sul2, and their potential environmental impact.
Multidrug Resistance Dynamics in Salmonella in Food Animals in the United States: An Analysis of Genomes from Public Databases.
The study analyzed 22,102 Salmonella genomes from public databases to track antimicrobial resistance (AMR) trends in food animals in the United States. It found that the prevalence of multidrug resistance (MDR) decreased in bovines and swine but increased in poultry. Key AMR genes identified include bla CMY-2, bla CTX-M-65, floR, tetA, sul2, aadA2, aac(3)-VIa, qnrB19, qnrB2, bla SHV-12, bla TEM-1, bla CARB-2, aph(3")-Ib, aph(6)-Id, aph(3')-Ia, ant(3")-Ia, aph(4)-Ia, and aac(3)-IVa. A significant mutation, gyrA D87Y, was associated with quinolone resistance in poultry.
Antimicrobial Resistance Profiles of Escherichia coli Isolated from Broiler and Layer Chickens in Arusha and Mwanza, Tanzania.
The study identified bla TEM and bla CTX-M genes in Escherichia coli isolates from broiler and layer chickens in Tanzania, contributing to resistance against ampicillin.
Drug susceptibility and molecular epidemiology of Escherichia coli in bloodstream infections in Shanxi, China.
The study identified several AMR genes, including bla CTX-M-14, bla TEM-1, bla CTX-M-15, bla OXA-1, and bla CTX-M-55, in Escherichia coli isolates from bloodstream infections in Shanxi, China.
The antimicrobial resistance landscape of Neisseria gonorrhoeae in New Zealand from November 2018 to March 2019 and the role of sexual orientation in transmission.
The study identified several AMR genes and mutations in Neisseria gonorrhoeae isolates from New Zealand, including blaTEM-1, blaTEM-135, tetM, 23S C2611T, rpsJ V57M, mtrR A39T, mtrR G45D, penA mutations, penB mutations, ponA L421P, gyrA mutations, parC mutations, and norM promoter mutations, which contribute to resistance against various antibiotics such as penicillin, tetracycline, azithromycin, ciprofloxacin, ceftriaxone, and cefixime.
The antimicrobial resistance landscape of Neisseria gonorrhoeae in New Zealand from November 2018 to March 2019 and the role of sexual orientation in transmission.
The study identified several AMR genes and mutations in Neisseria gonorrhoeae isolates from New Zealand, including blaTEM-1, blaTEM-135, tetM, 23S C2611T, rpsJ V57M, mtrR A39T, mtrR G45D, penA mutations, penB mutations, ponA L421P, gyrA mutations, parC mutations, and norM promoter mutations, which contribute to resistance against various antibiotics such as penicillin, tetracycline, azithromycin, ciprofloxacin, ceftriaxone, and cefixime.
Virulence determinants and antimicrobial resistance of E. coli isolated from bovine clinical mastitis in some selected dairy farms of Bangladesh.
The study identified tetracycline resistance gene tetA in 100% of tetracycline-resistant E. coli isolates and blaTEM-1 in 38.9% of E. coli isolates, highlighting the presence of multidrug-resistant E. coli in bovine clinical mastitis.
Bacteriological and histopathological findings in cetaceans that stranded in the Philippines from 2017 to 2018.
The study identified multiple antibiotic-resistant bacteria from cetaceans stranded in the Philippines, highlighting the presence of resistance genes such as ermB, aadA, aac(6')-Ib, blaTEM, blaCTX-M, blaSHV, blaOXA, qnrS1, tet(A), and mph(A).
Molecular epidemiology of antibiotic-resistant genes and potent inhibitors against TEM, CTX-M-14, CTX-M-15, and SHV-1 proteins of Escherichia coli in district Peshawar, Pakistan.
The study identified the presence of ESBL genes including bla-CTX-M, bla-TEM, bla-SHV, and bla-CTX-M-14 in E. coli isolates from Peshawar, Pakistan. These genes were responsible for resistance to various antibiotics such as cephalosporins, penicillins, and aztreonam.
Genomic Determinants of Pathogenicity and Antimicrobial Resistance for 60 Global Listeria monocytogenes Isolates Responsible for Invasive Infections.
The study identified several antimicrobial resistance genes in Listeria monocytogenes isolates, including beta-lactam resistance genes blaTEM-101 and blaTEM-105, macrolide resistance gene ermC-15, aminoglycoside resistance genes aadA10_2, aadA6_1, and aadA6_2, quinolone resistance gene oqxB_1, and sulfonamide resistance gene sul4_1.
Genomic Determinants of Pathogenicity and Antimicrobial Resistance for 60 Global Listeria monocytogenes Isolates Responsible for Invasive Infections.
The study identified several antimicrobial resistance genes in Listeria monocytogenes isolates, including beta-lactam resistance genes blaTEM-101 and blaTEM-105, macrolide resistance gene ermC-15, aminoglycoside resistance genes aadA10_2, aadA6_1, and aadA6_2, quinolone resistance gene oqxB_1, and sulfonamide resistance gene sul4_1.
Genetic evaluation of ESBL-producing Escherichia coli urinary isolates in Otago, New Zealand.
The study identified various ESBL genes, including bla CTX-M, bla TEM, bla SHV, and bla OXA, in ESBL-producing E. coli isolates from Otago, New Zealand. The most prevalent ESBL gene was bla CTX-M, with several subtypes such as CTX-M-14, CTX-M-15, CTX-M-27, and CTX-M-55. Additionally, other beta-lactamase genes like bla CMY-2 were also detected. The study highlights the genetic diversity of ESBL-Ec isolates and the presence of multiple resistance mechanisms.
Efficacy and mechanism of carvacrol with octanoic acid against mastitis causing multi-drug-resistant pathogens.
The study identified the presence of bla CTX-M, bla SHV, and bla TEM genes in E. coli FcW5, which confer resistance to various beta-lactam antibiotics. These genes were experimentally validated through PCR amplification and sequencing.
Plasmid-mediated colistin resistance and ESBL production in Escherichia coli from clinically healthy and sick pigs
The study identifies mcr-1, mcr-3, bla CTX-M14, bla CTX-M55, and bla TEM-1B as key genes responsible for colistin resistance and ESBL production in E. coli isolates from pigs. These genes were found on various plasmids and their co-transfer was observed during conjugation experiments.
Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units.
The study evaluated the use of respiratory metagenomics to detect antimicrobial resistance genes and improve treatment of secondary infections in ICU patients. It identified several beta-lactam resistance genes, macrolide resistance genes, and sulfonamide resistance genes in various bacterial species.
Phenotypic and genotypic detection of extended spectrum β-lactamases among Escherichia coli and Klebsiella pneumoniae isolates from type 2 diabetic patients with urinary tract infections.
The study identified blaTEM and blaSHV genes as the primary contributors to ESBL production in E. coli and K. pneumoniae isolates from T2DM patients with UTIs, with blaTEM being the most prevalent.
Geographic Patterns of Carbapenem-Resistant Pseudomonas aeruginosa in the Asia-Pacific Region: Results from the Antimicrobial Testing Leadership and Surveillance (ATLAS) Program, 2015-2019.
The study identified various carbapenemase genes, including blaVIM, blaNDM, blaVEB, blaIMP, blaGES, blaTEM, and blaKPC, in carbapenem-resistant Pseudomonas aeruginosa isolates from the Asia-Pacific region.
Invasive atypical non-typhoidal Salmonella serovars in The Gambia.
The study identified several antimicrobial resistance genes in invasive Salmonella serovars in The Gambia, including blaTEM-1B, aph(3'')-Ib, aph(6)-Id, catA1, dfrA7, sul1, sul2, tet(B), and fosA7. These genes conferred resistance to various antibiotics such as ampicillin, penicillin, gentamicin, kanamycin, tobramycin, chloramphenicol, trimethoprim, sulfamethoxazole, tetracycline, and fluoroquinolones.
Co-conjugation of Virulence Plasmid and KPC Plasmid in a Clinical Klebsiella pneumoniae Strain.
The study characterizes a carbapenem-resistant hypervirulent Klebsiella pneumoniae strain that harbors a conjugative virulence plasmid and a bla KPC–2-bearing plasmid. The virulence plasmid contains multiple resistance genes, including bla KPC–2, qnrB4, bla DHA–1, sul1, msr(E), mph(E), bla TEM–1B, aac(3)-IId, bla SHV–12, mph(A), bla CTX–M–65, bla TEM–1B, fosA3, and rmtB. The study also shows that these plasmids can be transferred to other bacterial strains, contributing to the spread of multidrug-resistant and hypervirulent K. pneumoniae.
Effective Antimicrobial Solutions for Eradicating Multi-Resistant and β-Lactamase-Producing Nosocomial Gram-Negative Pathogens.
The study identifies several β-lactamase genes, including bla TEM, bla AmpC, and bla CTX-M1, which contribute to multidrug resistance in various Gram-negative pathogens. These genes were detected through PCR and phenotypic analysis, highlighting their role in resistance to penicillins and cephalosporins.
Mobile Antimicrobial Resistance Genes in Probiotics.
The study identified several antimicrobial resistance genes (ARGs) in probiotic samples, including rpoB mutants conferring resistance to rifampicin, TEM-116, and tet(W/N/W). These genes were associated with mobile genetic elements, raising concerns about their potential transfer to human gut bacteria.
High Prevalence of Antibiotic-Resistant Escherichia coli Isolates from Retail Poultry Products in Spain.
The study identified blaTEM as the primary beta-lactam resistance gene and tet(A) as the dominant tetracycline resistance gene in E. coli isolates from retail poultry products in Spain.
Impact of Antibiotic Therapies on Resistance Genes Dynamic and Composition of the Animal Gut Microbiota.
The study examined the impact of antibiotic therapies on the dynamics and composition of resistance genes in the animal gut microbiota, identifying several AMR genes such as blaTEM, tetA, strA, strB, intI1, tetM, mel, floR, mcr-2, oqx B, tetC, tetG, tetO, tetW, tetX, ermB, ermF, sul1, sul2, and others, which were experimentally validated in Escherichia coli.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
The study identified various CTX-M-type beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, bla CTX-M-55, and bla CTX-M-65, as well as other beta-lactamase genes such as bla TEM-1, bla CARB-2, and bla CMY-2 in ESBL E. coli isolates from sheep and their abattoir environment. Additional AMR genes related to aminoglycosides, macrolides, phenicols, quinolones, sulfonamides, tetracyclines, and trimethoprim were also detected.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
The study identified various CTX-M-type beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, bla CTX-M-55, and bla CTX-M-65, as well as other beta-lactamase genes such as bla TEM-1, bla CARB-2, and bla CMY-2 in ESBL E. coli isolates from sheep and their abattoir environment. Additional AMR genes related to aminoglycosides, macrolides, phenicols, quinolones, sulfonamides, tetracyclines, and trimethoprim were also detected.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
The study identified various CTX-M-type beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, bla CTX-M-55, and bla CTX-M-65, as well as other beta-lactamase genes such as bla TEM-1, bla CARB-2, and bla CMY-2 in ESBL E. coli isolates from sheep and their abattoir environment. Additional AMR genes related to aminoglycosides, macrolides, phenicols, quinolones, sulfonamides, tetracyclines, and trimethoprim were also detected.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
The study identified various CTX-M-type beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, bla CTX-M-55, and bla CTX-M-65, as well as other beta-lactamase genes such as bla TEM-1, bla CARB-2, and bla CMY-2 in ESBL E. coli isolates from sheep and their abattoir environment. Additional AMR genes related to aminoglycosides, macrolides, phenicols, quinolones, sulfonamides, tetracyclines, and trimethoprim were also detected.
Molecular characterization of Escherichia coli isolated from milk samples with regard to virulence factors and antibiotic resistance.
The study identified E. coli isolates from raw milk samples carrying virulence factors eae, hly, and stx2, along with antibiotic resistance genes blaTEM, tetA(A), and tetB, demonstrating multidrug resistance to several antibiotics.
First report from Bangladesh on genetic diversity of multidrug-resistant Pasteurella multocida type B:2 in fowl cholera.
The study identified multidrug-resistant Pasteurella multocida type B:2 strains in fowl cholera cases in Bangladesh, highlighting the presence of various virulence factors and antimicrobial resistance genes.
Comparison of antimicrobial resistance and molecular characterization of Escherichia coli isolates from layer breeder farms in Korea.
The study identified several AMR genes in E. coli isolates from layer breeder farms in Korea, including bla TEM-1, tetA, tetB, qnrB, qnrS, sul1, sul2, aac(3)-II, and aac(6')-Ib. These genes conferred resistance to various antibiotics such as beta-lactams, tetracyclines, quinolones, sulfonamides, and aminoglycosides.
Mouse pneumonia model by Acinetobacter baumannii multidrug resistant strains: Comparison between intranasal inoculation, intratracheal instillation and oropharyngeal aspiration techniques.
The study identified various AMR genes in two multidrug-resistant Acinetobacter baumannii strains, ACC001 and ACC002, including aminoglycoside resistance genes, tetracycline resistance genes, beta-lactamases, and sulfonamide resistance genes. These genes contribute to resistance against multiple antibiotics such as gentamicin, tobramycin, tetracycline, penicillins, cephalosporins, and sulfonamides.
Prevalence of genotypic antimicrobial resistance in clinical Shiga toxin-producing Escherichia coli in Norway, 2018 to 2020.
The study identified a low prevalence of genotypic antimicrobial resistance in clinical STEC in Norway, with aminoglycoside resistance being the most common. Key resistance genes included strA, strB, aadA1, sul1, sul2, tetA, blaTEM-1B, and dfrA1.
Genomic Characterization of Extensively Drug-Resistant NDM-Producing Acinetobacter baumannii Clinical Isolates With the Emergence of Novel bla (ADC-257).
The study identified several AMR genes, including novel bla ADC-257, and mutations in gyrA and parC associated with fluoroquinolone resistance in extensively drug-resistant NDM-producing Acinetobacter baumannii isolates.
Prevalence and Characteristics of Ceftriaxone-Resistant Salmonella in Children's Hospital in Hangzhou, China.
The study identified various beta-lactamase genes, including bla CTX-M-55, bla CTX-M-65, bla CTX-M-14, bla CTX-M-9, bla CTX-M-64, bla CTX-M-130, bla CMY-2, bla TEM-1, bla TEM-215, bla OXA-1, bla OXA-10, and bla LAP-2, as the primary resistance mechanisms for ceftriaxone-resistant Salmonella. Additionally, the mcr-1 gene was found to confer resistance to colistin.
Prevalence and Characteristics of Ceftriaxone-Resistant Salmonella in Children's Hospital in Hangzhou, China.
The study identified various beta-lactamase genes, including bla CTX-M-55, bla CTX-M-65, bla CTX-M-14, bla CTX-M-9, bla CTX-M-64, bla CTX-M-130, bla CMY-2, bla TEM-1, bla TEM-215, bla OXA-1, bla OXA-10, and bla LAP-2, as the primary resistance mechanisms for ceftriaxone-resistant Salmonella. Additionally, the mcr-1 gene was found to confer resistance to colistin.
Epidemiology and population structure of Haemophilus influenzae causing invasive disease.
The study identified blaTEM-1 and blaROB-1 beta-lactamase genes in Haemophilus influenzae isolates, which conferred resistance to ampicillin, and blaROB-1 also conferred resistance to cefuroxime and cefepime. Additionally, amino acid substitutions in PBP3 and mutations in GyrA and ParC were associated with beta-lactam and fluoroquinolone resistance, respectively.
Molecular characterization of enterohemorrhagic Escherichia coli isolated from diarrhea samples from human, livestock, and ground beef in North Jordan.
The study identified ESBL-producing EHEC isolates carrying bla SHV and bla TEM genes, indicating resistance to beta-lactam antibiotics.
Clonal groups of extended-spectrum beta-lactamase and biofilm producing uropathogenic Escherichia coli in Iran.
The study identified various beta-lactamase genes, including bla TEM, bla CTX-M, bla OXA-1, bla IMP, bla VIM, bla KPC, and bla OXA-48, in biofilm-producing uropathogenic Escherichia coli strains from Iran, highlighting their role in multidrug resistance.
Genomic diversity of antimicrobial resistance in non-typhoidal Salmonella in Victoria, Australia.
The study identified various AMR genes and mutations in non-typhoidal Salmonella, including bla TEM-1, bla TEM-135, strAB, sul1, sul2, tet(A), tet(B), floR, bla CMY-2, bla CTX-M-55, and bla CTX-M-65, along with mutations in gyrA and parC contributing to ciprofloxacin resistance.
Genomic diversity of antimicrobial resistance in non-typhoidal Salmonella in Victoria, Australia.
The study identified various AMR genes and mutations in non-typhoidal Salmonella, including bla TEM-1, bla TEM-135, strAB, sul1, sul2, tet(A), tet(B), floR, bla CMY-2, bla CTX-M-55, and bla CTX-M-65, along with mutations in gyrA and parC contributing to ciprofloxacin resistance.
Genomic comparisons of Escherichia coli ST131 from Australia.
The study identifies multiple AMR genes and mutations in Australian E. coli ST131 isolates, including bla CTX-M-15 and bla CTX-M-27 for beta-lactam resistance, aadA5, strA, strB, mphA, dfrA17, sul1, qacEΔ1, and chrA for resistance to aminoglycosides, macrolides, trimethoprim, sulfonamides, quaternary ammonium compounds, and chromate. Fluoroquinolone resistance mutations in gyrA and parC were also found.
The Relationship between Antibiotic Susceptibility and pH in the Case of Uropathogenic Bacteria.
The study identified several AMR genes including aac(69)-Ib-cr, oqxAB, sul2, tem, shv, ctx-m, and oxa in uropathogenic bacteria. These genes were associated with resistance to various antibiotics such as gentamicin, ciprofloxacin, norfloxacin, and trimethoprim/sulfamethoxazole.
Antimicrobial Susceptibility and Frequency of bla and qnr Genes in Salmonella enterica Isolated from Slaughtered Pigs.
The study identified the presence of bla TEM and bla CTX-M genes in 61.2% of Salmonella enterica isolates, along with qnrA, qnrB, and qnrS genes, contributing to antimicrobial resistance against β-lactams and fluoroquinolones.
Prevalence and Antimicrobial Resistance Profiles of Foodborne Pathogens Isolated from Dairy Cattle and Poultry Manure Amended Farms in Northeastern Ohio, the United States.
The study identified several antimicrobial resistance genes in foodborne pathogens isolated from dairy cattle and poultry manure amended farms in Northeastern Ohio, including mphA, aadA, aphA1, tetA, aac(3)-IV, sulII, blaTEM, tetB, strA, aac(3)-Iva, ampC, lde, ermB, tet(O), aadB, penA, blaOXA-61, aadE, and aph-3-1.
Antimicrobial Resistance in Salmonella Isolated from Food Workers and Chicken Products in Japan.
The study identified several beta-lactamase genes, including bla CMY-2, bla CTX-M-15, bla CTX-M-55, bla TEM-52B, bla LAT-3, bla LAP-2, and bla TEM-1, which were associated with cefotaxime resistance in Salmonella isolates from food workers and chicken products in Japan.
Antimicrobial Resistance in Salmonella Isolated from Food Workers and Chicken Products in Japan.
The study identified several beta-lactamase genes, including bla CMY-2, bla CTX-M-15, bla CTX-M-55, bla TEM-52B, bla LAT-3, bla LAP-2, and bla TEM-1, which were associated with cefotaxime resistance in Salmonella isolates from food workers and chicken products in Japan.
Pan-Resistome Characterization of Uropathogenic Escherichia coli and Klebsiella pneumoniae Strains Circulating in Uganda and Kenya, Isolated from 2017-2018.
The study identified various AMR genes in uropathogenic E. coli and K. pneumoniae strains from Uganda and Kenya, highlighting the prevalence of multidrug-resistant (MDR) and extended-spectrum beta-lactamase (ESBL)-producing strains.
Antimicrobial Resistance of Salmonella enteritidis and Salmonella typhimurium Isolated from Laying Hens, Table Eggs, and Humans with Respect to Antimicrobial Activity of Biosynthesized Silver Nanoparticles.
The study identified several AMR genes, including blaTEM, tetA, tetB, nfsA, and nfsB, in multidrug-resistant Salmonella enteritidis and Salmonella typhimurium isolates. These genes conferred resistance to ampicillin, tetracycline, and nitrofurantoin. Additionally, biosynthesized silver nanoparticles showed promising antimicrobial activity against these resistant strains.
Whole-Genome Sequencing-Based Antimicrobial Resistance Characterization and Phylogenomic Investigation of 19 Multidrug-Resistant and Extended-Spectrum Beta-Lactamase-Positive Escherichia coli Strains Collected From Hospital Patients in Benin in 2019.
The study identified multiple AMR genes and mutations in 19 ESBL-positive E. coli isolates from Benin, including bla CTX-M-15, bla OXA-1, bla TEM-1, aac(6')-Ib-cr, qnrS1, tet(B), sul2, and dfrA17, as well as mutations in parC and gyrA associated with fluoroquinolone resistance.
ESBL Producing Escherichia coli in Faecal Sludge Treatment Plants: An Invisible Threat to Public Health in Rohingya Camps, Cox's Bazar, Bangladesh.
The study identified several ESBL genes, including bla CTX-M-1, bla CTX-M-15, and bla TEM, in ESBL-producing E. coli isolates from faecal sludge treatment plants in Rohingya camps. These genes conferred resistance to multiple beta-lactam antibiotics.
Prevalence of ESBL and AmpC genes in E. coli isolates from urinary tract infections in the north of Iran.
The study identified the prevalence of ESBL and AmpC genes in E. coli isolates from urinary tract infections in the north of Iran, highlighting the significant presence of blaSHV, blaTEM, blaCTX-M, MOX, EBC, and CIT genes.
Detection and characterisation of extended-spectrum and plasmid-mediated AmpC beta-lactamase produced by Escherichia coli isolates found at poultry farms in Bosnia and Herzegovina.
The study identified bla CTX-M-1 cluster, bla CTX-M-15, and bla TEM genes in Escherichia coli isolates from poultry farms in Bosnia and Herzegovina, indicating the presence of extended-spectrum beta-lactamases and plasmid-mediated AmpC beta-lactamases.
Dissemination and genome analysis of high-level ceftriaxone-resistant penA 60.001 Neisseria gonorrhoeae strains from the Guangdong Gonococcal antibiotics susceptibility Programme (GD-GASP), 2016-2019.
The study identifies the penA 60.001 gene as a key factor in ceftriaxone and penicillin resistance in Neisseria gonorrhoeae strains, alongside the blaTEM-1B gene contributing to penicillin resistance.
Penicillinase plasmid Australia type in Neisseria gonorrhoeae isolated in Poland.
The study identified the Australia-type penicillinase plasmid in Neisseria gonorrhoeae for the first time in Europe, highlighting the presence of TEM-1 and TEM-135 beta-lactamase genes.
Recurring outbreaks by the same Escherichia coli ST10 clone in a broiler unit during 18 months.
The study identifies multiple antimicrobial resistance genes, including blaTEM-1B, tetA, dfrA1/sul2, and floR, in E. coli ST10 isolates causing recurrent outbreaks in a broiler unit over 18 months.
Genotypic and Phenotypic Characterization of Novel Sequence Types of Carbapenem-Resistant Acinetobacter baumannii, With Heterogeneous Resistance Determinants and Targeted Variations in Efflux Operons.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii strains, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, contributing to multidrug resistance.
Prevalence, Risk Factors, and Genetic Characterization of Extended-Spectrum Beta-Lactamase Escherichia coli Isolated From Healthy Pregnant Women in Madagascar.
The study identified blaCTX-M-15 as the most prevalent ESBL gene in ESBL-producing E. coli isolates from pregnant women in Madagascar, along with other CTX-M variants, blaNDM-5, blaCMY-2, and resistance genes such as qnrS1, sul2, dfrA14, aph(6)-Id, and aph(3')-Ib.
Antimicrobial Resistance of Escherichia coli From Aquaculture Farms and Their Environment in Zhanjiang, China.
The study identified multiple antimicrobial resistance (AMR) genes in Escherichia coli isolates from aquaculture farms in Zhanjiang, China, including blaTEM, blaCIT, floR, OptrA, cmlA, aphA1, Sul2, oqxA, qnrS, and mcr1. These genes conferred resistance to various antibiotics such as beta-lactams, chloramphenicol, florfenicol, aminoglycosides, sulfonamides, quinolones, and colistin.
Surveillance of antimicrobial-resistant Escherichia coli in Sheltered dogs in the Kanto Region of Japan.
The study identified beta-lactamase genes (blaTEM, blaDHA-1, blaCTX-M-9 group CTX-M-14), quinolone-resistance protein genes (qnrB, qnrS), and mutations in quinolone-resistance-determining regions (gyrA and parC) in multidrug-resistant E. coli isolates from shelter dogs in the Kanto Region of Japan.
Prevalence and characterization of antimicrobial resistance among gram-negative bacteria isolated from febrile hospitalized patients in central Ethiopia.
High prevalence of ESBL-producing gram-negative bacteria (81.5%) and carbapenem resistance (7.4%) was observed, with more than half of the isolates carrying two or more ESBL genes. The study highlights the need for improved antimicrobial stewardship and local resistance monitoring.
Resistance Patterns, mcr-4 and OXA-48 Genes, and Virulence Factors of Escherichia coli from Apennine Chamois Living in Sympatry with Domestic Species, Italy.
The study identified the colistin resistance gene mcr-4 and carbapenems resistance gene OXA-48 in Escherichia coli isolates from wild and domestic ungulates in Italy, highlighting the presence of these resistance mechanisms in wildlife.
One Health Genomic Study of Human and Animal Klebsiella pneumoniae Isolated at Diagnostic Laboratories on a Small Caribbean Island.
The study identified various AMR genes in Klebsiella pneumoniae isolates from humans and animals on St. Kitts, including bla CTX-M-15, bla TEM-1b, bla TEM-206, bla OXA-1, and others, highlighting host-specific differences in resistance profiles.
One Health Genomic Study of Human and Animal Klebsiella pneumoniae Isolated at Diagnostic Laboratories on a Small Caribbean Island.
The study identified various AMR genes in Klebsiella pneumoniae isolates from humans and animals on St. Kitts, including bla CTX-M-15, bla TEM-1b, bla TEM-206, bla OXA-1, and others, highlighting host-specific differences in resistance profiles.
Role of AmpC-Inducing Genes in Modulating Other Serine Beta-Lactamases in Escherichia coli.
The study shows that ampD and ampE play roles in modulating the expression of serine beta-lactamases (CTX-M-15, TEM-1, and OXA-2) in E. coli, affecting beta-lactam resistance.
Antimicrobial Susceptibility Profiles among Pseudomonas aeruginosa Isolated from Professional SCUBA Divers with Otitis Externa, Swimming Pools and the Ocean at a Diving Operation in South Africa.
The study identified multiple beta-lactamase genes (blaAmpC, blaTEM, blaOxa-4, CTX-M1, blaSHV), sulfonamide resistance genes (sul1, sul2), and integron genes (IntI1, IntI2) in P. aeruginosa isolates from SCUBA divers, swimming pools, and the ocean in Sodwana Bay, South Africa, indicating a high level of multidrug resistance.
The Darkest Place Is under the Candlestick-Healthy Urogenital Tract as a Source of Worldwide Disseminated Extraintestinal Pathogenic Escherichia coli Lineages.
The study identified several AMR genes and mutations in E. coli strains from the urogenital microbiome of healthy women, including blaTEM-30, tet(A), aac(3)-IId, sul1, dfrA12, and a gyrA mutation (S83L) conferring resistance to various antibiotics.
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
The study identified several beta-lactamase genes, including bla CTX-M-27, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla SHV-12, and bla TEM-1, which confer resistance to beta-lactam antibiotics. Other resistance genes such as aadA5, aph(3")-Ib, aph(6)-Id, mph(A), sul1, sul2, tet(A), and dfrA17, dfrA12, dfrA1, and dfrA14 were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates in Finland.
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
The study identified several beta-lactamase genes, including bla CTX-M-27, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla SHV-12, and bla TEM-1, which confer resistance to beta-lactam antibiotics. Other resistance genes such as aadA5, aph(3")-Ib, aph(6)-Id, mph(A), sul1, sul2, tet(A), and dfrA17, dfrA12, dfrA1, and dfrA14 were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates in Finland.
Plasmid Carrying bla (CTX-M-15), bla (PER-1), and bla (TEM-1) Genes in Citrobacter spp. From Regional Hospital in Mexico.
The study identifies the presence of blaCTX-M-15, blaPER-1, and blaTEM-1 genes in Citrobacter spp. isolates, which confer resistance to various beta-lactam antibiotics.
Colistin Resistance in Monophasic Isolates of Salmonella enterica ST34 Collected From Meat-Derived Products in Spain, With or Without CMY-2 Co-production.
The study identifies the mcr-1.1 gene on IncX4 and IncHI2 plasmids as the primary determinant of colistin resistance in Salmonella enterica ST34 isolates from meat products in Spain. Additionally, the bla CMY-2 gene on an IncI1-I(α) plasmid was found to confer resistance to cefotaxime and cefoxitin.
High-resolution genomic surveillance elucidates a multilayered hierarchical transfer of resistance between WWTP- and human/animal-associated bacteria.
The study identifies multiple plasmid-borne AMR genes, including blaTEM-1, aph(3')-I, floR, and tetA, which confer resistance to ampicillin, kanamycin, chloramphenicol, and tetracycline, respectively. These genes are primarily located on conjugative plasmids and show potential for horizontal transfer between WWTP- and human/animal-associated bacteria.
High-Resolution Melting Analysis to Detect Antimicrobial Resistance Determinants in South African Neisseria gonorrhoeae Clinical Isolates and Specimens.
The study identified several AMR genes and mutations in N. gonorrhoeae, including bla TEM, tetM, rpsJ_V57M, gyrA_S91F, 16S_rRNA_C1192U, mtrR_G45D, penA_G545S, and penA_mosaic, which are associated with resistance to penicillin, tetracycline, ciprofloxacin, spectinomycin, azithromycin, cefixime, and ceftriaxone.
Virulence and antimicrobial resistance profile of non-typhoidal Salmonella enterica serovars recovered from poultry processing environments at wet markets in Dhaka, Bangladesh.
The study identified several AMR genes in non-typhoidal Salmonella enterica serovars from poultry processing environments in Bangladesh, including bla TEM, tet A, sul 1, and str A/B, which conferred resistance to various antibiotics such as ampicillin, tetracycline, sulfamethoxazole-trimethoprim, and streptomycin.
Whole genome sequencing-based classification of human-related Haemophilus species and detection of antimicrobial resistance genes.
The study identifies blaTEM-1D and tetB as resistance genes in Haemophilus isolates, correlating with ampicillin and tetracycline resistance, respectively.
S. algae as a reservoir and a vehicle of potential antimicrobial resistance
The study identified multiple antimicrobial resistance genes in S. algae strains, including genes conferring resistance to beta-lactams, aminoglycosides, quinolones, phenicols, macrolides, sulfonamides, tetracyclines, and lincosamides.
Population snapshot of the extended-spectrum β-lactamase-producing Escherichia coli invasive strains isolated from a Hungarian hospital.
The study identified bla CTX-M-15, bla CTX-M-27, and bla TEM-1B as the primary beta-lactamase genes responsible for extended-spectrum beta-lactamase (ESBL) production in E. coli isolates. Additionally, qnrB19 and aac(3)-IIa were found to contribute to fluoroquinolone and aminoglycoside resistance, respectively.
Therapeutic effect of biosynthetic gold nanoparticles on multidrug-resistant Escherichia coli and Salmonella species isolated from ruminants.
The study identified beta-lactam resistance genes bla TEM, bla SHV, bla OXA, and bla CTX-M in multidrug-resistant E. coli and Salmonella spp. isolated from ruminants. These genes conferred resistance to ampicillin, amoxicillin, and cefotaxime.
Advanced Oxidation Processes for Inactivation of Antibiotic Resistance Genes in Wastewater
The paper discusses the fate of antibiotic resistance genes (ARGs) during wastewater treatment processes, highlighting the inefficiency of conventional methods in removing ARGs and the potential of UV and chlorine-based advanced oxidation processes (AOPs) for inactivating ARGs. It emphasizes the need for improved wastewater treatment strategies to mitigate the spread of antibiotic resistance.
Plasmid-mediated colistin resistance and ESBL production in Escherichia coli from clinically healthy and sick pigs.
The study identified mcr-3, bla CTX-M-14, bla CTX-M-55, bla TEM-1, and bla CMY-2 as key AMR genes in E. coli isolates from pigs in Thailand. Additionally, several mutations in PmrA and PmrB were associated with colistin resistance.
Flomoxef and fosfomycin in combination for the treatment of neonatal sepsis in the setting of highly prevalent antimicrobial resistance.
The study evaluated the combination of flomoxef and fosfomycin for treating neonatal sepsis in settings with high antimicrobial resistance. It found that the combination showed synergy in bacterial killing and prevented the emergence of fosfomycin resistance. Specific AMR genes and mutations were identified in Enterobacterales strains, including beta-lactamases and efflux pumps.
Application of mNGS in the Etiological Analysis of Lower Respiratory Tract Infections and the Prediction of Drug Resistance.
The study identified several AMR genes using mNGS, including bla OXA-23, bla OXA-51, bla TEM, bla CTX-M, bla SHV, bla KPC, and mecA, which were associated with resistance to various antibiotics in different bacterial species.
Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial.
Early-life broad-spectrum antibiotics alter the infant gut microbiome and resistome, with amoxicillin + cefotaxime having the most significant impact on AMR gene profiles.
Genetic diversity and multidrug resistance of phylogenic groups B2 and D in InPEC and ExPEC isolated from chickens in Central China.
The study identifies several AMR genes and mutations in E. coli isolates from chickens in Central China, including aminoglycoside resistance genes strA, strB, and aadA, beta-lactamase genes CTX-M, SHV, OXA, and TEM, and quinolone resistance mutations S83L and D87N in gyrA.
UK dogs eating raw meat diets have higher risk of Salmonella and antimicrobial-resistant Escherichia coli faecal carriage.
The study found that dogs fed raw meat diets had a higher prevalence of antimicrobial-resistant Escherichia coli, including those resistant to third-generation cephalosporins and carrying genes such as bla CTX-M, bla TEM, qnr, and bla AmpC.
Prevalence, Antimicrobial Resistance, and Whole Genome Sequencing Analysis of Shiga Toxin-Producing Escherichia coli (STEC) and Enteropathogenic Escherichia coli (EPEC) from Imported Foods in China during 2015-2021.
The study identified several antimicrobial resistance genes in STEC and EPEC isolates from imported foods in China, including blaTEM-1B, tetA, tetB, catA1, cmlA1, aadA1, aph(4)-Ia, aac(3)-IV, aph(6)-Id, aph(3")-Ib, sul3, dfrA12, and qnrS1, which conferred resistance to various antibiotics such as ampicillin, tetracycline, chloramphenicol, gentamicin, trimethoprim-sulfamethoxazole, and ciprofloxacin.
Antimicrobial Resistance (AMR) of Bacteria Isolated from Dogs with Canine Parvovirus (CPV) Infection: The Need for a Rational Use of Antibiotics in Companion Animal Health.
The study identified several beta-lactamase genes, including blaTEM, blaCTX-M-II, blaSHV, blaOXA, and blaDHA, which confer resistance to various antibiotics in bacteria isolated from dogs with canine parvovirus infection.
Similarities in Virulence and Extended Spectrum Beta-Lactamase Gene Profiles among Cefotaxime-Resistant Escherichia coli Wastewater and Clinical Isolates.
The study identifies several beta-lactamase genes, including blaCTX-M-1, blaKPC-2, blaTEM-350, blaOXA-1, and blaCTX-M-15, as well as various aminoglycoside, macrolide, and tetracycline resistance genes in cefotaxime-resistant E. coli isolates from hospital and urban wastewater. Mutations in parC, parE, and gyrA contribute to fluoroquinolone resistance.
Detection of Carbapenem Resistance of Proteus mirabilis Strains Isolated from Foxes, Raccoons and Minks in China.
The study identified several AMR genes in Proteus mirabilis isolates from foxes, raccoons, and minks in China, including blaTEM, blaOXA-1, aac(6′)Ib-cr, floR, sul1, blaNDM, and blaOXA-24. These genes conferred resistance to various antibiotics, with a high prevalence of multidrug-resistant isolates.
Comparison of Reference-Based Assembly and De Novo Assembly for Bacterial Plasmid Reconstruction and AMR Gene Localization in Salmonella enterica Serovar Schwarzengrund Isolates.
The study identified various AMR genes in Salmonella enterica serovar Schwarzengrund isolates, including aadA2, AAC(3)-IV, AAC(6')-Iy, APH(4)-Ia, cmlA1, dfrA12, floR, sul1, sul2, sul3, TEM-1, and tet(A). These genes were located on both the chromosome and plasmids, highlighting the importance of plasmid-mediated AMR gene transmission.
Overcoming Multidrug Resistance in Salmonella spp. Isolates Obtained From the Swine Food Chain by Using Essential Oils: An in vitro Study.
The study identified several AMR genes in Salmonella isolates from the swine food chain, including parC, catA1, nfsB, nfsA, blaTEM, tetA, and tetB, which confer resistance to various antibiotics such as gentamicin, amikacin, tobramycin, chloramphenicol, ampicillin, piperacillin, and tetracycline.
Comparative Analysis of Bacillus cereus Group Isolates' Resistance Using Disk Diffusion and Broth Microdilution and the Correlation between Antimicrobial Resistance Phenotypes and Genotypes.
The study identified several antimicrobial resistance genes in Bacillus cereus group isolates, including beta-lactamase-encoding genes (bla1, blaZ, blaTEM), mph for erythromycin resistance, rph for rifampicin resistance, and fosB for fosfomycin resistance. These genes were detected using ABRIcate and MEGARes 2.0 database, and their association with resistance phenotypes was analyzed.
First identification of bla (NDM-5) producing Escherichia coli from neonates and a HIV infected adult in Tanzania.
The study identifies bla NDM-5 producing Escherichia coli in Tanzania, highlighting the presence of carbapenem resistance and other resistance genes on various plasmids.
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China.
The study identifies multiple antimicrobial resistance genes in multidrug-resistant E. coli isolates from pig farms in China, including ESBL genes, fluoroquinolone resistance genes, carbapenem resistance genes, and colistin resistance genes. It highlights the widespread presence of these resistance mechanisms and their potential to spread to human pathogens.
Whole-genome sequencing for the characterization of resistance mechanisms and epidemiology of colistin-resistant Acinetobacter baumannii.
The study identified several beta-lactam resistance genes, including ADC-18, OXA-133, OXA-23, OXA-66, TEM-1, VIM-2, and RND efflux pumps (adeI, adeJ, adeK, adeN) in colistin-resistant Acinetobacter baumannii strains.
Yersinia pestis antibiotic resistance: a systematic review.
Genomic characterization of multidrug-resistant Salmonella serovar Kentucky ST198 isolated in poultry flocks in Spain (2011-2017).
The study identified multiple antimicrobial resistance genes in multidrug-resistant Salmonella serovar Kentucky ST198 isolates from Spain, including genes conferring resistance to aminoglycosides, beta-lactams, sulfonamides, tetracyclines, trimethoprim, and colistin.
Genomic characterization of multidrug-resistant Salmonella serovar Kentucky ST198 isolated in poultry flocks in Spain (2011-2017).
The study identified multiple antimicrobial resistance genes in multidrug-resistant Salmonella serovar Kentucky ST198 isolates from Spain, including genes conferring resistance to aminoglycosides, beta-lactams, sulfonamides, tetracyclines, trimethoprim, and colistin.
Whole genome sequence of pan drug-resistant clinical isolate of Acinetobacter baumannii ST1890.
The study identified multiple antibiotic resistance genes in the pan-drug-resistant Acinetobacter baumannii strain VJR422, including genes encoding beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps, contributing to resistance against various antibiotic classes.
High prevalence of antibiotic resistance in pathogenic foodborne bacteria isolated from bovine milk.
The study identified bla TEM, bla SHV, mec A, and bla Z genes in E. coli, Salmonella spp., and S. aureus isolates from bovine milk, highlighting the high prevalence of antibiotic resistance in foodborne pathogens.
Antimicrobial Resistance and Virulence of Non-Typhoidal Salmonella from Retail Foods Marketed in Bangkok, Thailand.
The study identified several AMR genes in Salmonella Enteritidis isolates from retail food samples in Bangkok, including blaTEM-1, tetA, sul2, and dfrA7, which confer resistance to various antibiotics.
Genetic Characterization of Antibiotic Resistant Enterobacteriaceae Isolates From Bovine Animals and the Environment in Nigeria.
The study characterizes antibiotic resistance genes in Enterobacteriaceae isolates from bovine animals and the environment in Nigeria, identifying several beta-lactamase, aminoglycoside modifying enzymes, qnr, sulfonamide, tetracycline, and trimethoprim resistance genes, highlighting the presence of multidrug-resistant strains.
Genetic Characterization of Antibiotic Resistant Enterobacteriaceae Isolates From Bovine Animals and the Environment in Nigeria.
The study characterizes antibiotic resistance genes in Enterobacteriaceae isolates from bovine animals and the environment in Nigeria, identifying several beta-lactamase, aminoglycoside modifying enzymes, qnr, sulfonamide, tetracycline, and trimethoprim resistance genes, highlighting the presence of multidrug-resistant strains.
Virulence determinant and antimicrobial resistance traits of Emerging MDR Shiga toxigenic E. coli in diarrheic dogs.
The study identified several AMR genes in MDR Shiga toxigenic E. coli (STEC) isolated from diarrheic dogs in Egypt, including bla TEM, bla CTX-M, bla KPC, bla NDM-1, tet A, tet B, sul 1, and qnr A. These genes confer resistance to various antibiotics such as penicillins, cephalosporins, carbapenems, tetracyclines, sulfonamides, and quinolones.
Assessing bacterial diversity and antibiotic resistance dynamics in wastewater effluent-irrigated soil and vegetables in a microcosm setting.
The study identified the bla TEM gene as the only beta-lactam resistance gene in wastewater effluent, effluent-treated soil, and vegetables, highlighting the potential dissemination of antibiotic resistance genes through wastewater irrigation.
Global population structure of the Serratia marcescens complex and identification of hospital-adapted lineages in the complex.
The study identified multiple antimicrobial resistance (AMR) genes and mutations in the Serratia marcescens complex, highlighting the presence of hospital-adapted lineages with a high prevalence of multidrug-resistant (MDR) strains. Key AMR genes include blaCTX-M, blaNDM, blaOXA, qnrS1, tet(A), aac(6')-Ib, mph(A), erm(B), aadA, floR, sul1, and dfrA12, which confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, tetracyclines, aminoglycosides, macrolides, florfenicol, sulfonamides, and trimethoprim.
Gut Commensal Escherichia coli, a High-Risk Reservoir of Transferable Plasmid-Mediated Antimicrobial Resistance Traits.
The study identified multiple plasmid-mediated antimicrobial resistance genes in gut commensal Escherichia coli isolates from healthy individuals, highlighting the potential risk of these bacteria as reservoirs of resistance traits.
Association between Timing of Colonization and Risk of Developing Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Infection in Hospitalized Patients.
The study identifies blaSHV-11 and blaTEM-1 as genes responsible for carbapenem resistance in KPC-producing Klebsiella pneumoniae isolates, highlighting their role in multidrug resistance.
Characterization of the Resistome and Microbiota in Children with Community-Acquired Pneumonia
Children receiving 5 days of beta-lactam therapy for CAP had a significantly lower abundance of antibiotic resistance determinants than those receiving standard 10-day treatment.
Genomics of human and chicken Salmonella isolates in Senegal: Broilers as a source of antimicrobial resistance and potentially invasive nontyphoidal salmonellosis infections.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella isolates from Senegal, highlighting the prevalence of resistance to fluoroquinolones, sulfamethoxazole-trimethoprim, tetracycline, and erythromycin. Key genes included aac(3)-Id, aadA7, blaTEM-1b, blaDHA-1, blaOXA-10, blaCMY-2, dfrA1, dfrA14, floR, fosA, qnrB19, qnrB7, sul2, tetA, tetB, aph(3')-Ib, aph(3")-Ib, and aph(6)-Id. Mutations in parC and gyrA were also associated with fluoroquinolone resistance.
Antibiotic and Heavy Metal Resistance in Escherichia coli: Mechanisms and Implications
The study identifies several beta-lactamase genes (blaTEM-1, blaCTX-M-15, blaNDM-1) and the arsRBC operon associated with heavy metal resistance in E. coli strains.
A Ternary Copper (II) Complex with 4-Fluorophenoxyacetic Acid Hydrazide in Combination with Antibiotics Exhibits Positive Synergistic Effect against Salmonella Typhimurium.
The study identified bla TEM and bla CTX-M-2 as the primary beta-lactam resistance genes in Salmonella Typhimurium strains, contributing to resistance against ampicillin, ceftriaxone, and meropenem.
Pathogenic E. coli from Cattle as a Reservoir of Resistance Genes to Various Groups of Antibiotics.
The study identified various AMR genes in pathogenic E. coli strains from cattle in Romania and France, highlighting the presence of multidrug-resistant (MDR) strains and the diversity of resistance mechanisms.
Invited Review: Antimicrobial Use and Antimicrobial Resistance in Pathogens Associated with Diarrhea and Pneumonia in Dairy Calves.
The review identified several AMR genes in pathogens associated with calf diarrhea and pneumonia, including beta-lactamases (blaCMY, blaCTX-M, blaTEM), tetracycline resistance genes (tetA, tetB, tetM, tetO), aminoglycoside resistance genes (strA, strB, aadA), sulfonamide resistance genes (sul1, sul2), phenicol resistance genes (cat, floR), and macrolide/lincosamide resistance genes (cfr, ermB).
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
The study identified multiple AMR genes in multidrug-resistant E. coli and K. pneumoniae isolates from Kuwait, including beta-lactamases (blaKPC-2, blaCTX-M-15, blaOXA-1, blaCMY-4, blaTEM), aminoglycoside-modifying enzymes (aac(3)-IIa, aph(6)-Id, aadA5), sulfonamide resistance genes (sul1, sul2), quinolone resistance genes (gyrA_D87N, qnrB1), and others. Colistin resistance was linked to the pmrB_R256G mutation.
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
The study identified multiple AMR genes in multidrug-resistant E. coli and K. pneumoniae isolates from Kuwait, including beta-lactamases (blaKPC-2, blaCTX-M-15, blaOXA-1, blaCMY-4, blaTEM), aminoglycoside-modifying enzymes (aac(3)-IIa, aph(6)-Id, aadA5), sulfonamide resistance genes (sul1, sul2), quinolone resistance genes (gyrA_D87N, qnrB1), and others. Colistin resistance was linked to the pmrB_R256G mutation.
Identification, Characterization, and Virulence Gene Expression of Marine Enterobacteria in the Upper Gulf of Thailand.
The study identified and characterized beta-lactamase genes (ampC, blaSHV, and blaTEM) in marine enterobacteria from the Upper Gulf of Thailand, highlighting their role in resistance to β-lactam antibiotics such as ampicillin and ticarcillin.
Characterization of Uropathogenic Escherichia coli Reveals Hybrid Isolates of Uropathogenic and Diarrheagenic (UPEC/DEC) E. coli.
The study identified ESBL-producing UPEC isolates carrying bla CTX-M-15-group, bla CTX-M-8-group, and bla CMY-2 genes, along with bla TEM-1, contributing to resistance against various beta-lactam antibiotics.
Use of genomics to explore AMR persistence in an outdoor pig farm with low antimicrobial usage.
The study identified various AMR genes in E. coli isolates from a low antimicrobial usage pig farm, highlighting the persistence of multidrug-resistant strains despite minimal selective pressure.
Clonal spread of carbapenemase-producing Enterobacterales in a region, China.
The study identified blaKPC-2 and blaNDM as the most prevalent carbapenemase genes in carbapenem-resistant Enterobacterales (CRE) isolates, with blaKPC-2 being dominant in Klebsiella pneumoniae and blaNDM in various species. The clonal spread of ST11 KPC-2 Klebsiella pneumoniae was highlighted as a key contributor to the rise in CRE in the region.
Isolation, Identification, Characterization, and Plasmid Profile of Urinary Tract Infectious Escherichia coli from Clinical Samples.
The study identified the presence of TEM, CTX-M, SHV, and OXA beta-lactamase genes in E. coli isolates, contributing to multidrug resistance, particularly to beta-lactam antibiotics.
Nitrogen Regulates the Distribution of Antibiotic Resistance Genes in the Soil-Vegetable System.
The study identified that nitrogen application affects the abundance of antibiotic resistance genes (ARGs) such as blaTEM-1, sul1, and tnpA-4 in the soil-vegetable system, but does not alter their distribution patterns within the vegetable. The findings highlight the importance of nitrogen management in controlling ARG transfer and accumulation in crops.
Ultrafast and Cost-Effectiveness Pathogen Identification and Resistance Gene Detection in a Clinical Setting Using Nanopore Flongle Sequencing.
The study demonstrates the effectiveness of Oxford Nanopore Technology's Flongle sequencing for rapid bacterial identification and detection of antibiotic resistance genes (ARGs) in clinical settings. It identifies several beta-lactamase genes (TEM-1B, CTX-M-2, CTX-M-14, CTX-M-35, SHV-187) and other resistance genes (fosA, oqxA) in Escherichia coli and Klebsiella pneumoniae isolates.
Emergence of extensively drug-resistant Aeromonas hydrophila complex isolated from wild Mugil cephalus (striped mullet) and Mediterranean seawater.
The study identified extensively drug-resistant (XDR) Aeromonas hydrophila complex from wild Mugil cephalus and Mediterranean seawater, carrying resistance genes blaTEM, sul1, and tetA(A), and the virulence gene act. None of the isolates carried the aadA1 gene despite phenotypic resistance to streptomycin.
Prevalence and Molecular Characterization of Extended Spectrum β-Lactamase and Carbapenemase-Producing Enterobacteriaceae Isolates from Bloodstream Infection Suspected Patients in Addis Ababa, Ethiopia.
The study identified bla CTX-M, bla SHV, bla TEM, and bla NDM genes as prevalent in Enterobacteriaceae isolates from bloodstream infections in Ethiopia, highlighting the significance of these genes in conferring resistance to beta-lactam antibiotics.
Inter-species geographic signatures for tracing horizontal gene transfer and long-term persistence of carbapenem resistance.
The study characterizes various carbapenem resistance genes such as blaKPC, blaNDM, blaOXA-48, blaVIM, blaIMP, blaGES, blaSIM, blaTEM, blaSHV, blaCTX-M, ampC, mecA, vanA, vanB, vanC, mcr-1, mcr-2, mcr-3, mcr-4, and mcr-5 in Enterobacterales and other bacterial species, highlighting their role in carbapenem resistance and horizontal gene transfer.
Relationship and distribution of Salmonella enterica serovar I 4,[5],12:i:- strain sequences in the NCBI Pathogen Detection database.
The study identified the presence of the MDR module and SGI-4 in Salmonella enterica serovar I 4,[5],12:i:- strains, which confer resistance to multiple antimicrobial classes including ampicillin, streptomycin, sulfisoxazole, and tetracycline.
Using whole-genome sequence data to examine the epidemiology of antimicrobial resistance in Escherichia coli from wild meso-mammals and environmental sources on swine farms, conservation areas, and the Grand River watershed in southern Ontario, Canada.
The study identified several AMR genes in E. coli isolates from wild meso-mammals and environmental sources, including blaTEM-1, tet(A), tet(B), sul1, sul2, aph(3”)-Ib, aph(6)-Id, blaCMY-2, qnrS1, and floR. These genes conferred resistance to various antibiotics such as beta-lactams, tetracyclines, sulfonamides, aminoglycosides, and quinolones.
Development of multidrug-resistant Escherichia coli in some Egyptian veterinary farms.
The study identified bla TEM and tetA genes in amoxicillin and oxytetracycline-resistant Escherichia coli isolates from Egyptian veterinary farms, indicating the presence of multidrug-resistant E. coli.
Phenotypic and molecular characterization of beta-lactamase and plasmid-mediated quinolone resistance genes in Klebsiella oxytoca isolated from slaughtered pigs in Thailand.
The study identified bla CTX-M, bla TEM, and qnrS as the primary resistance genes in Klebsiella oxytoca isolates from slaughtered pigs in Thailand, with bla CTX-M being the most prevalent.
Piperacillin/tazobactam-resistant, cephalosporin-susceptible Escherichia coli bloodstream infections are driven by multiple acquisition of resistance across diverse sequence types.
The study identifies various beta-lactamase genes, including bla TEM-1, bla TEM-33, bla CTX-M-15, bla OXA-1, and bla SHV-1, as well as the S133G mutation in bla CTX-M-15, which contribute to piperacillin/tazobactam resistance in Escherichia coli bloodstream infections.
Piperacillin/tazobactam-resistant, cephalosporin-susceptible Escherichia coli bloodstream infections are driven by multiple acquisition of resistance across diverse sequence types.
The study identifies various beta-lactamase genes, including bla TEM-1, bla TEM-33, bla CTX-M-15, bla OXA-1, and bla SHV-1, as well as the S133G mutation in bla CTX-M-15, which contribute to piperacillin/tazobactam resistance in Escherichia coli bloodstream infections.
Litter Commensal Bacteria Can Limit the Horizontal Gene Transfer of Antimicrobial Resistance to Salmonella in Chickens.
The study identifies several AMR genes, including blaTEM-1B, tetA, aadA1, mer operon, sul2, silABCFRS, pcoABCDRS, iroBCDEN, and intI1, which are associated with Salmonella enterica serovar Heidelberg isolates from both fresh and reused litter. These genes contribute to resistance against various antibiotics such as ampicillin, tetracycline, gentamicin, sulfonamide, silver, copper, and mercury.
Large-Scale Genomic Epidemiology of Klebsiella pneumoniae Identified Clone Divergence with Hypervirulent Plus Antimicrobial-Resistant Characteristics Causing Within-Ward Strain Transmissions.
The study identified clone divergence in Klebsiella pneumoniae, particularly highlighting the emergence of hypervirulent plus antimicrobial-resistant (hv+AMR) subclones. Key AMR genes such as bla KPC-2, bla CTX-M-65, and others were characterized, along with virulence factors like rmpA, rmpA2, and ybt.
Community Fecal Carriage and Molecular Epidemiology of Extended-Spectrum β-Lactamase- and Carbapenemase-Producing Escherichia coli from Healthy Children in the Central South China.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, and others, as well as the carbapenemase gene bla NDM-1 in Escherichia coli isolates from healthy children in China. Additionally, the colistin resistance gene mcr-1 was detected in one ESBL-EC isolate.
Drinking water chlorination has minor effects on the intestinal flora and resistomes of Bangladeshi children.
The study identified several antibiotic resistance genes (ARGs) in the gut microbiome of Bangladeshi children, including bla CTX-M, mph(A), qnrS1, mdf(A), tet(A), sul2, aadA5, tet(X), erm(X), nimE, dfrA17, bla TEM, and ant(6’)-Ia. These genes were associated with resistance to various antibiotics such as third-generation cephalosporins, azithromycin, fluoroquinolones, tetracyclines, sulfonamides, streptomycin, spectinomycin, macrolides, lincosamides, streptogramin B, nitroimidazoles, trimethoprim, penicillins, and aminoglycosides.
A MoS(2) based silver-doped ZnO nanocomposite and its antibacterial activity against beta-lactamase expressing Escherichia coli.
The study characterizes the antibacterial activity of a MoS2-based silver-doped ZnO nanocomposite (AZM) against beta-lactamase-expressing multidrug-resistant (MDR) Escherichia coli strains. It identifies several beta-lactamase genes (bla AmpC, bla TEM-1, bla CTX-M-27, bla ESBL, bla NDM-1) and the mcr-1 gene as critical determinants of resistance in these strains.
Analysis of Antimicrobial Resistance in Non-typhoidal Salmonella Collected From Pork Retail Outlets and Slaughterhouses in Vietnam Using Whole Genome Sequencing.
The study identified several AMR genes in non-typhoidal Salmonella isolates from pork retail outlets and slaughterhouses in Vietnam, including blaTEM-1, blaTEM-150, blaLAP-2, blaCTX-M-55, dfrA12, dfrA14, floR, cmlA1, tetA, tetB, tetM, mcr-1, mcr-3, qnrS1, mphA, aadA1, aadA2, aac(6')-laa, aac(6')-ly, sul1, sul2, sul3, aph(3")-lb, and aph6-ld. These genes conferred resistance to various antibiotics such as ampicillin, penicillins, first-generation cephalosporins, quinolones, trimethoprim, chloramphenicol, tetracycline, colistin, macrolides, gentamicin, sulfonamides, and others.
Analysis of Antimicrobial Resistance in Non-typhoidal Salmonella Collected From Pork Retail Outlets and Slaughterhouses in Vietnam Using Whole Genome Sequencing.
The study identified several AMR genes in non-typhoidal Salmonella isolates from pork retail outlets and slaughterhouses in Vietnam, including blaTEM-1, blaTEM-150, blaLAP-2, blaCTX-M-55, dfrA12, dfrA14, floR, cmlA1, tetA, tetB, tetM, mcr-1, mcr-3, qnrS1, mphA, aadA1, aadA2, aac(6')-laa, aac(6')-ly, sul1, sul2, sul3, aph(3")-lb, and aph6-ld. These genes conferred resistance to various antibiotics such as ampicillin, penicillins, first-generation cephalosporins, quinolones, trimethoprim, chloramphenicol, tetracycline, colistin, macrolides, gentamicin, sulfonamides, and others.
Identifying the Sources of Intestinal Colonization With Extended-Spectrum β-Lactamase-Producing Escherichia coli in Healthy Infants in the Community.
The study identifies several AMR genes, including blaCTX-M-15, qnrS1, ermB, aadA1, aph(3')-Ib, aph(6)-Id, dfrA1, catA1, aadA2, dfrA5, dfrA12, qnrS13, aac(6')-Ib-cr5, blaTEM-1, blaOXA-1, sul1, and dfrA17, associated with ESBL-Ec in children, mothers, and drinking water in rural Bangladesh.
Epidemiology of Klebsiella michiganensis Carrying Multidrug-Resistant IncHI5 Plasmids in the Southeast Coastal Area of China.
The study identified multiple AMR genes on IncHI5 plasmids in Klebsiella michiganensis, including beta-lactamases (blaCTX-M-3, blaTEM-1, blaSHV-12, blaIMP-4, blaNDM-1, blaOXA-1, blaOXA-16, blaSFO-1, blaSIM-1), aminoglycoside modifying enzymes (aacA4, arr3, aadA5, gcu37, dfrA1), chloramphenicol acetyltransferase (catA2), streptomycin resistance genes (strA, strB), macrolide resistance genes (msrAB, mph(A)), and quaternary ammonium compound resistance gene (qacG2).
Multiplex Digital Quantification of beta-lactamase Genes in Antibiotic-Resistant Bacteria by Counting Gold Nanoparticle Labels on Silicon Microchips.
The study presents a method for the digital quantification of beta-lactamase genes using gold nanoparticle labels on silicon microchips, demonstrating the ability to detect and quantify specific beta-lactamase genes such as blaCTX-M-3, blaCTX-M-5, blaTEM-1, and blaVIM-1 in bacterial isolates.
Antimicrobial Resistance in Escherichia coli from the Broiler Farm Environment, with Detection of SHV-12-Producing Isolates.
The study identifies SHV-12-producing Escherichia coli isolates in a broiler farm environment, highlighting the presence of various antimicrobial resistance genes such as bla SHV-12, cmlA, tet (A), aac(6′)-Ib-cr, and others. These genes confer resistance to multiple antibiotics, emphasizing the need for monitoring and controlling AMR in agricultural settings.
TEM,CTX-M,SHV Genes in ESBL-Producing Escherichia coli and Klebsiella pneumoniae Isolated from Clinical Samples in a County Clinical Emergency Hospital Romania-Predominance of CTX-M-15.
The study identifies the prevalence of bla CTX-M-15, bla SHV-1, and bla TEM-1 genes in ESBL-producing E. coli and K. pneumoniae isolates, highlighting the dominance of CTX-M-15. It also detects tetracycline resistance genes tet(A) and tet(B).
High Carriage of Extended-Spectrum, Beta Lactamase-Producing, and Colistin-Resistant Enterobacteriaceae in Tibetan Outpatients with Diarrhea.
The study identified the presence of extended-spectrum beta-lactamase (ESBL)-producing and colistin-resistant Enterobacteriaceae in Tibetan outpatients with diarrhea, highlighting the significance of antimicrobial resistance in this population.
Wild Duck (Anas platyrhynchos) as a Source of Antibiotic-Resistant Salmonella enterica subsp. diarizonae The First Report in Poland.
The study identified the presence of aadA, strA/strB, and blaTEM genes in a multidrug-resistant Salmonella enterica subsp. diarizonae strain isolated from a wild mallard duck in Poland.
Food Is Reservoir of MDR Salmonella: Prevalence of ESBLs Profiles and Resistance Genes in Strains Isolated from Food.
The study identified bla SHV, bla CTX-M, and bla TEM genes in ESBL-producing Salmonella strains isolated from food samples, highlighting the prevalence of multidrug-resistant Salmonella in food sources.
Antimicrobial resistance in Escherichia coli isolated from on-farm and conventional hatching broiler farms in Ireland.
The study identified bla TEM-1 and bla CMY-2 as the primary beta-lactamase genes responsible for cefotaxime resistance in E. coli isolates from both on-farm and conventional hatching systems in Ireland.
Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017.
The study identified several AMR genes in K. pneumoniae isolates, including bla CTX-M-15, bla SHV-27, bla SHV-1, bla SHV-101, bla SHV-108, bla TEM-1B, qnrB66, aac(3)-IIa, dfrA14, strA, strB, sul2, and tet(A). These genes conferred resistance to various antibiotics such as beta-lactams, quinolones, aminoglycosides, sulfonamides, and tetracyclines.
Genetic Characterization of Four Groups of Chromosome-Borne Accessory Genetic Elements Carrying Drug Resistance Genes in Providencia.
This study characterizes four groups of chromosome-borne accessory genetic elements (AGEs) in Providencia, highlighting the diversity and complexity of multidrug resistance (MDR) regions within these elements. It identifies numerous drug resistance genes, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and others, contributing to the understanding of AMR mechanisms in Providencia.
Multidrug Resistance Genes Carried by a Novel Transposon Tn7376 and a Genomic Island Named MMGI-4 in a Pathogenic Morganella morganii Isolate.
The study identifies a novel transposon Tn7376 and a genomic island MMGI-4 in a multidrug-resistant Morganella morganii isolate, carrying multiple antimicrobial resistance genes including dfrA24, mph(A), aadA1, sul1, floR, catA2, cmlA1, aph(3')-Ia, aac(6')-Ib-cr, tet(A), tet(B), arr-3, blaTEM-1B, blaDHA-17, blaCARB-2, blaOXA-1, blaCTX-M-3, and fosA3.
Characteristics of ST11 KPC-2-producing carbapenem-resistant hypervirulent Klebsiella pneumoniae causing nosocomial infection in a Chinese hospital.
The study identified ST11 KPC-2-producing carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) as the main type causing nosocomial infections in a Chinese hospital. Key resistance genes included bla KPC-2, bla CTX-M-65, bla SHV-11, bla SHV-12, and bla TEM-1, which conferred resistance to various beta-lactam antibiotics.
Molecular typing and prevalence of antibiotic resistance and virulence genes in Streptococcus agalactiae isolated from Chinese dairy cows with clinical mastitis.
The study identified the TEM gene as the primary beta-lactam resistance gene in Streptococcus agalactiae isolates from Chinese dairy cows, with 98% detection rate. All isolates were susceptible to aminoglycosides.
Characterization of multi-resistant Shigella species isolated from raw cow milk and milk products.
The study identified multiple antibiotic resistance genes in Shigella species isolated from raw cow milk and milk products in Egypt, including blaTEM, blaCTX-M, tet(A), and qacEdelta1. These genes conferred resistance to various antibiotics and disinfectants, highlighting the emergence of multidrug-resistant Shigella strains.
Analysis of Salmonella enterica Isolated from a Mixed-Use Watershed in Georgia, USA: Antimicrobial Resistance, Serotype Diversity, and Genetic Relatedness to Human Isolates.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from a mixed-use watershed in Georgia, USA, including bla CMY-2, aadA2, strA, strB, sul1, sul2, tetA, tetC, floR, and dfrA12, which conferred resistance to various antibiotics such as ceftiofur, ceftriaxone, streptomycin, sulfisoxazole, tetracycline, chloramphenicol, and trimethoprim.
Antimicrobial Susceptibility Survey of Invasive Haemophilus influenzae in the United States in 2016.
The study identified bla TEM-1 and bla ROB-1 beta-lactamase genes as major contributors to ampicillin resistance in H. influenzae, along with ftsI mutations leading to β-lactam resistance.
Characterization of Antibiotic Resistant Coliform Bacteria and Resistance Genes Isolated from Samples of Smoothie Drinks and Raw Milk.
The study identified antibiotic-resistant coliform bacteria in smoothie drinks and raw milk, highlighting the presence of resistance genes such as bla OXA, bla TEM, and bla SHV, which confer resistance to beta-lactam antibiotics like ampicillin.
Hybrid Plasmids Encoding Antimicrobial Resistance and Virulence Traits Among Hypervirulent Klebsiella pneumoniae ST2096 in India.
The study characterizes hybrid plasmids in MDR-HvKp ST2096 isolates from India, identifying multiple AMR genes such as bla NDM-5, bla OXA-232, aadA2, armA, and others, along with virulence genes like rmpA2 and iucABCD.
An Outbreak of ST859-K19 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae in a Chinese Teaching Hospital.
The study reports an outbreak of ST859-K19 carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) in a Chinese hospital, identifying several resistance and virulence genes, including blaKPC-2, blaTEM-1B, blaSHV-187, rmtB, qnrS1, fosA6, and various virulence factors.
Highly prevalent MDR, frequently carrying virulence genes and antimicrobial resistance genes in Salmonella enterica serovar 4,[5],12:i:- isolates from Guizhou Province, China.
The study identified multiple antimicrobial resistance genes, including bla TEM-1, strA-strB, sul2, tetB, and bla CTX-M, in Salmonella enterica serovar 4,[5],12:i:- isolates from Guizhou, China, highlighting the high prevalence of multidrug resistance.
Genome-wide identification of carbapenem-resistant Gram-negative bacterial (CR-GNB) isolates retrieved from hospitalized patients in Bihar, India.
The study identified several carbapenem-resistant genes, including bla CTX-M, bla SHV, bla TEM, bla OXA, bla NDM, and bla DIM, in Gram-negative bacterial isolates from Bihar, India. These genes were found to confer resistance to various antibiotics, highlighting the prevalence of carbapenem resistance in the region.
Prevalence of extended-spectrum β-lactamase-producing Enterobacterales in retail sheep meat from Zagazig city, Egypt.
The study identified bla CTX-M, bla TEM, and bla SHV genes in ESBL-producing E. coli isolates from retail sheep meat in Egypt, highlighting the prevalence of these resistance mechanisms.
Cefixime and cefixime-clavulanate for screening and confirmation of extended-spectrum beta-lactamases in Escherichia coli.
The study identified CTX-M, TEM, and SHV genes as the primary extended-spectrum beta-lactamase (ESBL) genes in E. coli isolates, with CTX-M being the most prevalent.
Epidemiology, Environmental Risks, Virulence, and Resistance Determinants of Klebsiella pneumoniae From Dairy Cows in Hubei, China.
The study identified several AMR genes in K. pneumoniae isolates from dairy cows in Hubei, China, including blaTEM, blaSHV, strA, strB, aadA1, and aac(6')-Ib-cr, which contribute to resistance against various antibiotics.
Prevalence, Characteristics, and Clonal Distribution of Escherichia coli Carrying Mobilized Colistin Resistance Gene mcr-1.1 in Swine Farms and Their Differences According to Swine Production Stages.
The study identified the mobilized colistin resistance gene mcr-1.1 in Escherichia coli isolates from swine farms, highlighting its prevalence and association with multidrug resistance.
Molecular Characterization of ESBLs and QnrS Producers From Selected Enterobacteriaceae Strains Isolated From Commercial Poultry Production Systems in Kiambu County, Kenya.
The study identified several ESBL genes (bla TEM, bla CTX-M, bla OXA, bla SHV) and the QnrS gene in Enterobacteriaceae isolates from commercial poultry in Kenya, highlighting the prevalence of multidrug-resistant bacteria in poultry production systems.
Occurrence and Genomic Characterization of Clone ST1193 Clonotype 14-64 in Uncomplicated Urinary Tract Infections Caused by Escherichia coli in Spain.
The study identified the occurrence of fluoroquinolone-resistant ST1193 clone in uncomplicated urinary tract infections (uUTI) caused by Escherichia coli in Spain. Several AMR genes and mutations were characterized, including blaTEM-1B, aph(3')-Ib, aph(6)-Id, mdf(A), mph(A), sul2, dfrA14, dfrA17, sitABCD, and chromosomal mutations in gyrA (S83L, D87N), parC (S80I), and parE (L416F).
Diarrhoeagenic E. coli occurrence and antimicrobial resistance of Extended Spectrum Beta-Lactamases isolated from diarrhoea patients attending health facilities in Accra, Ghana.
The study identified bla TEM, bla CTX-M, and bla SHV genes as the primary extended spectrum beta-lactamase (ESBL) genes in Enterobacteriaceae isolates from diarrheal patients in Ghana. These genes conferred resistance to cephalosporins such as ceftazidime and cefotaxime.
Genetic Diversity, Biofilm Formation, and Antibiotic Resistance of Pseudomonas aeruginosa Isolated from Cow, Camel, and Mare with Clinical Endometritis.
The study identified several beta-lactamase genes, including bla TEM, bla CTX-M, bla SHV, and bla VIM, in Pseudomonas aeruginosa isolates from cows, camels, and mares with endometritis. These genes contribute to resistance against various antibiotics, highlighting the emergence of multidrug-resistant strains.
KPC-3-, GES-5-, and VIM-1-Producing Enterobacterales Isolated from Urban Ponds.
The study identified bla KPC-3, bla GES-5, and bla VIM genes in various Enterobacterales isolates from urban ponds, highlighting their role in carbapenem resistance.
Multidrug-Resistant and Extended-Spectrum beta-lactamase (ESBL)-Producing Enterobacterales Isolated from Carriage Samples among HIV Infected Women in Yaoundé, Cameroon.
The study identified bla TEM, bla CTX-M, and bla CTX-M-group-1,2,9 as the primary beta-lactamase genes contributing to multidrug resistance in Enterobacterales isolated from HIV-infected women in Yaoundé, Cameroon.
Antibiotic Resistance in Non-Typhoidal Salmonella enterica Strains Isolated from Chicken Meat in Indonesia.
The study identified several AMR genes, including blaTEM, aadA, tetA, and tetB, in NTS strains from chicken meat in Indonesia. Additionally, mutations in gyrA were linked to resistance to nalidixic acid and ciprofloxacin.
Antimicrobial Resistance and Virulence Characteristics of Klebsiella pneumoniae Isolates in Kenya by Whole-Genome Sequencing.
The study identified several AMR genes in K. pneumoniae isolates from Kenya, including blaCTX-M-15, blaTEM-181, blaOXA-181, blaNDM-1, mcr-8, armA, rmtF, aac(6')-Ib-cr, aph(3")-ib, aph(6)-id, dfrA, sul2, qnrB, tetA, and catII, which confer resistance to various antibiotics such as beta-lactams, carbapenems, aminoglycosides, fluoroquinolones, tetracyclines, and chloramphenicol.
ROCker Models for Reliable Detection and Typing of Short-Read Sequences Carrying beta-lactamase Genes.
The study presents ROCker models for the reliable detection and typing of beta-lactamase genes in short-read metagenomic data, demonstrating superior performance compared to existing methods.
Performance Characteristics of Next-Generation Sequencing for the Detection of Antimicrobial Resistance Determinants in Escherichia coli Genomes and Metagenomes.
The study identifies several AMR genes and mutations in E. coli ST38, including bla CTX-M-15, parC, gyrA, bla TEM-1, bla OXA-1, bla AmpC, and various mutations in gyrA, parC, cyaA, glpT, and PBP3 that confer resistance to beta-lactam, fluoroquinolone, and fosfomycin antibiotics.
Evolutionary Trajectories toward High-Level β-Lactam/beta-lactamase Inhibitor Resistance in the Presence of Multiple beta-lactamases.
The study identifies bla TEM-1, bla OXA-1, and bla CTX-M-15 as key beta-lactamase genes contributing to resistance against β-lactam/beta-lactamase inhibitor combinations. Additionally, specific mutations in bla CTX-M-15 (G238D, P167T, N132K) enhance resistance to ceftazidime-avibactam.
RETRACTED: Isolation and molecular characterization of extended spectrum beta lactamase producing Escherichia coli from chicken meat in Pakistan.
The study identified several AMR genes including blaOXA-1, blaTEM-1, blaCTX-M15, QnrS, TetA, AAC, AAD, Sul1, and Sul2 in E. coli isolates from chicken meat in Pakistan. Mutations in blaOXA-1 (H81Q), blaTEM-1 (C108Y, T214A, K284E, P301S), QnrS (H95R), and Sul2 (E66A) were also detected.
Escherichia coli ST1193: Following in the Footsteps of E. coli ST131
The paper characterizes Escherichia coli ST1193 as an emerging multidrug-resistant clone with various AMR determinants, including beta-lactamases (bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-55, bla OXA-1, bla TEM-1, bla CMY-42, bla CMY-2), aminoglycoside-modifying enzymes (aac(3)-IIa, aac(3)-IId, aac(6′)-Ib-cr, aadA1, aadA2, aadA5, aph(3′′)-Ib, aph(6)-Id), and other resistance genes (mcr-1, mph(A), erm(B), dfrA8, dfrA12, dfrA17, sul1, sul2, tetA, tetB).
Multidrug-resistant bacteria with ESBL genes: a growing threat among people living with HIV/AIDS in Nepal.
The study identified bla CTX-M and bla TEM genes in ESBL-producing bacteria, highlighting the emergence of multidrug-resistant Gram-negative pathogens among PLHA in Nepal.
Epidemiological investigation on drug resistance of Salmonella isolates from duck breeding farms in Shandong Province and surrounding areas, China.
The study identified 12 types of antibiotic resistance genes in 110 Salmonella isolates from duck farms in Shandong Province, China, including beta-lactam, aminoglycoside, tetracycline, macrolide, and quinolone resistance genes. The most prevalent resistance genes were blaTEM, aac(6')-Ib-cr, and tetA. The study also found that class I integrons and plasmids play a significant role in the dissemination of these resistance genes.
Phenotyping and genotyping studies on extended-spectrum β-lactamase-producing Escherichia coli isolates from mastitic cows on dairy farms in Egypt.
The study identified blaTEM and blaSHV genes as the most prevalent extended-spectrum beta-lactamase (ESBL) genes in Escherichia coli isolates from mastitic cows in Egypt. These genes confer resistance to several beta-lactam antibiotics.
Determination of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated from horses with respiratory manifestation.
The study identified the presence of the bla TEM gene in all seven K. pneumoniae isolates from horses with respiratory issues, indicating resistance to third-generation cephalosporins.
Case Report: Whole-Genome Sequencing of Serially Collected Haemophilus influenzae From a Patient With Common Variable Immunodeficiency Reveals Within-Host Evolution of Resistance to Trimethoprim-Sulfamethoxazole and Azithromycin After Prolonged Treatment With These Antibiotics.
The study identifies chromosomal mutations in Haemophilus influenzae that confer resistance to trimethoprim-sulfamethoxazole and azithromycin in a patient with common variable immunodeficiency, demonstrating within-host evolution of resistance during prolonged antibiotic treatment.
Epidemiological Characteristics of OXA-232-Producing Carbapenem-Resistant Klebsiella pneumoniae Strains Isolated during Nosocomial Clonal Spread Associated with Environmental Colonization.
The study identified OXA-232-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) strains that exhibited multidrug resistance, including resistance to carbapenems, cephalosporins, aminoglycosides, and quinolones. The strains were part of a clonal spread within the ICU, showing genetic similarities and carrying resistance genes such as blaOXA-232, blaCTX-M-15, blaSHV-106, and others.
Cross-Sectional Survey of Antibiotic Resistance in Extended Spectrum β-Lactamase-Producing Enterobacteriaceae Isolated from Pigs in Greece.
The study identified a high prevalence of ESBL-producing Enterobacteriaceae in Greek pigs, with a focus on resistance mechanisms involving bla CTX-M1/15, bla TEM, and bla SHV genes, as well as resistance to fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and colistin.
Prevalence and Molecular Characterisation of Extended-Spectrum Beta-Lactamase-Producing Shiga Toxin-Producing Escherichia coli, from Cattle Farm to Aquatic Environments.
The study identified several AMR genes, including sul1, sul2, bla OXA, bla CTX-M, bla TEM, and qnrS, in ESBL-producing STEC isolates from cattle farms and aquatic environments.
Sink survey to investigate multidrug resistance pattern of common foodborne bacteria from wholesale chicken markets in Dhaka city of Bangladesh.
The study identified bla TEM, qnrS, and mecA genes in foodborne bacteria from wholesale chicken markets in Dhaka, Bangladesh, indicating high levels of multidrug resistance.
Antimicrobial susceptibility and genomic profiling of Salmonella enterica from bloodstream infections at a tertiary referral hospital in Lusaka, Zambia, 2018-2019.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella enterica isolates, including blaTEM-1B, catA1, sul2, sul1, dfrA7, dfrA14, and mutations in gyrA, gyrB, and parC. These resistance mechanisms contribute to multidrug resistance and emerging resistance to ciprofloxacin and cephalosporins.
Covalent docking and molecular dynamics simulations reveal the specificity-shifting mutations Ala237Arg and Ala237Lys in TEM beta-lactamase.
The study identifies the specificity-shifting mutations Ala237Arg and Ala237Lys in TEM beta-lactamase, which enhance resistance to cefixime by forming salt bridges with the drug's negatively-charged R-group.
The occurrence of antimicrobial residues and antimicrobial resistance genes in urban drinking water and sewage in Southern Brazil.
The study identified the presence of antimicrobial resistance genes (ARGs) such as blaTEM and tetB in drinking water samples, along with antimicrobial residues like doxycycline. It also found various ARGs in sewage samples, highlighting the importance of water sources as reservoirs of AMR.
Retail chicken giblets contaminated with extended-spectrum cephalosporin- and carbapenem-resistant Salmonella enterica carrying blaCMY-2.
The study identified extended-spectrum cephalosporin- and carbapenem-resistant Salmonella enterica in retail chicken giblets, water tanks, and workers, carrying blaTEM, blaSHV, blaCMY-2, blaOXA-1, and blaKPC genes.
Biofilm Formation and Antimicrobial Susceptibility of E. coli Associated With Colibacillosis Outbreaks in Broiler Chickens From Saskatchewan.
The study identified several AMR genes in E. coli isolates from broiler chickens in Saskatchewan, including genes conferring resistance to tetracyclines, sulfonamides, trimethoprim, aminoglycosides, and beta-lactam antibiotics. Additionally, a multi-drug efflux pump gene (mdfA) was identified.
Effects of Dietary Antimicrobial Growth Promoters on Performance Parameters and Abundance and Diversity of Broiler Chicken Gut Microbiome and Selection of Antibiotic Resistance Genes.
The study identified several antibiotic resistance genes (ARGs) in the chicken gut microbiome, including blaCTX-M, mcr-1, and qnrS1, which were detected using conventional PCR. These genes were associated with resistance to beta-lactams, colistin, and fluoroquinolones, respectively.
Epidemiology of bla (CTX-M)-Positive Salmonella Typhimurium From Diarrhoeal Outpatients in Guangdong, China, 2010-2017.
The study identified bla CTX-M-55, bla CTX-M-14, and bla CTX-M-65 as the most prevalent CTX-M variants in S. Typhimurium isolates from diarrhoeal outpatients in Guangdong, China. It also reported the first detection of bla TEM-141 in S. Typhimurium.
Assessment of multidrug-resistant Listeria monocytogenes in milk and milk product and One Health perspective.
The study identified multiple antimicrobial resistance genes in Listeria monocytogenes isolates from milk and milk products, including beta-lactamase genes (bla TEM, bla SHV, bla Z), tetracycline resistance genes (tet A, tet D, tet G, tet K, tet M), sulfonamide resistance genes (sul 1, sul 2), and an aminoglycoside resistance gene (aph (3)-IIa (aphA2)).
In vitro Susceptibility to β-Lactam Antibiotics and Viability of Neisseria gonorrhoeae Strains Producing Plasmid-Mediated Broad- and Extended-Spectrum beta-lactamases.
The study characterized the resistance profiles of Neisseria gonorrhoeae strains carrying plasmid-mediated beta-lactamases, including blaTEM-1, blaTEM-135, and blaTEM-20. The TEM-20 beta-lactamase was identified as an extended-spectrum beta-lactamase (ESBL) capable of hydrolyzing both penicillins and cephalosporins.
In vitro Susceptibility to β-Lactam Antibiotics and Viability of Neisseria gonorrhoeae Strains Producing Plasmid-Mediated Broad- and Extended-Spectrum beta-lactamases.
The study characterized the resistance profiles of Neisseria gonorrhoeae strains carrying plasmid-mediated beta-lactamases, including blaTEM-1, blaTEM-135, and blaTEM-20. The TEM-20 beta-lactamase was identified as an extended-spectrum beta-lactamase (ESBL) capable of hydrolyzing both penicillins and cephalosporins.
In vitro Susceptibility to β-Lactam Antibiotics and Viability of Neisseria gonorrhoeae Strains Producing Plasmid-Mediated Broad- and Extended-Spectrum beta-lactamases.
The study characterized the resistance profiles of Neisseria gonorrhoeae strains carrying plasmid-mediated beta-lactamases, including blaTEM-1, blaTEM-135, and blaTEM-20. The TEM-20 beta-lactamase was identified as an extended-spectrum beta-lactamase (ESBL) capable of hydrolyzing both penicillins and cephalosporins.
Genomic and Evolutionary Analysis of Salmonella enterica Serovar Kentucky Sequence Type 198 Isolated From Livestock In East Africa.
The study identified multiple antimicrobial resistance genes in Salmonella enterica serovar Kentucky ST198 isolates from East Africa, including aac(3)-Id, aadA7, strA, strB, bla TEM-1B, sul1, and tet(A), which confer resistance to aminoglycosides, streptomycin, ampicillin, sulfamethoxazole, and tetracycline. Mutations in gyrA and parC were associated with ciprofloxacin resistance.
Calves as Main Reservoir of Antibiotic Resistance Genes in Dairy Farms.
The study identifies calves as the main reservoir of antibiotic resistance genes (ARGs) in dairy farms, highlighting the presence of bla TEM, erm B, sul 2, and tet A, which confer resistance to penicillins, MLS, sulfonamides, and tetracyclines, respectively.
Extended-spectrum Beta-lactamases Encoding Genes among Salmonella Enterica serovar Typhi Isolates in Patients with Typhoid Fever from four Academic Medical Centers Lagos, Nigeria.
The study identified the presence of ESBL-harboring S. Typhi isolates in patients with typhoid fever from Nigeria, highlighting the emergence of multidrug-resistant strains with blaCTX-M, blaSHV, and blaTEM genes.
Using Targeted Liquid Chromatography-Tandem Mass Spectrometry to Rapidly Detect β-Lactam, Aminoglycoside, and Fluoroquinolone Resistance Mechanisms in Blood Cultures Growing E. coli or K. pneumoniae.
The study developed and validated a targeted LC-MS/MS assay for the rapid detection of β-lactam, aminoglycoside, and fluoroquinolone resistance mechanisms in blood cultures growing E. coli or K. pneumoniae. The assay successfully detected various resistance genes including beta-lactamases (SHV, TEM, CTX-M-1-like, OXA-1, CMY-2-like, cAmpC, KPC, OXA-48, NDM, VIM), aminoglycoside-modifying enzymes (AAC(3)-Ia, AAC(3)-II, AAC(3)-IV, AAC(3)-VI, AAC(6′)-Ib, ANT(2′′)-I, APH(3′)-VI), 16S-RMTases (ArmA, RmtB, RmtC, RmtF), and quinolone resistance mechanisms (QnrA, QnrB, AAC(6′)-Ib-cr, and wildtype QRDR of GyrA).
Detection of Klebsiella pneumoniae antibiotic-resistant genes: An impending source of multidrug resistance dissemination through raw food.
The study identified several β-lactamase genes, including bla CTX-M, bla SHV, bla TEM, bla MOX, bla FOX, and carbapenemase genes such as bla NDM, bla IMP, bla VIM, and bla OXA-48, in Klebsiella pneumoniae isolates from raw food samples, highlighting the potential for multidrug resistance dissemination through the food chain.
Migratory birds as the vehicle of transmission of multi drug resistant extended spectrum β lactamase producing Escherichia fergusonii, an emerging zoonotic pathogen.
The study identified CTX-M and TEM-1 beta-lactamase genes in multidrug-resistant Escherichia fergusonii isolates from migratory birds, highlighting their role in the spread of antibiotic resistance.
Proposal of a Method for Harmonized Broth Microdilution Antimicrobial Susceptibility Testing of Avibacterium gallinarum.
The study identified several antimicrobial resistance genes in Avibacterium gallinarum, including bla TEM, dfrA14, sul2, tet(B), and tet(H), which confer resistance to various antibiotics such as penicillin, trimethoprim, sulfamethoxazole, and tetracyclines.
Extended Spectrum β-Lactamase Activity and Cephalosporin Resistance in Escherichia coli from U.S. Mid-Atlantic Surface and Reclaimed Water.
The study identified bla TEM, bla CMY-2, and bla CTX-M genes in Escherichia coli isolates from surface and reclaimed water, contributing to cephalosporin resistance.
Emergence and Evolution of Unique Plasmids Harboring bla(IMP-70) and bla(CTX-M-253) in Multidrug-Resistant Providencia rettgeri.
The study identifies bla(IMP-70) and bla(CTX-M-253) as novel beta-lactamase genes in multidrug-resistant Providencia rettgeri, highlighting their role in carbapenem and cephalosporin resistance.
First Report of bla (CTX-M-167), bla (SHV-1), and bla (TEM-1B) Carrying Klebsiella pneumonia Showing High-Level Resistance to Carbapenems.
The study identifies the first report of a carbapenem-resistant Klebsiella pneumoniae strain carrying bla CTX-M-167, bla TEM-1B, and bla SHV-1, along with other resistance genes such as qnrS1, aac(6')-1b-cr, aadA16, tet(A), fosA, sul1, and mph(A).
Molecular Characterization of Klebsiella pneumoniae Isolated from Sputum in a Tertiary Hospital in Xinxiang, China.
The study identified several AMR genes in K. pneumoniae isolates, including bla SHV, bla CTX-M, bla TEM, aac, qnr B, and oqx B, which contribute to resistance against beta-lactams, aminoglycosides, and quinolones. The presence of these genes highlights the severity of antibiotic resistance in the region.
Distribution of ESBL/AmpC-Escherichia coli on a Dairy Farm.
The study identified ESBL/AmpC-producing E. coli on a dairy farm, with a high prevalence in calves. Key resistance genes included blaCTX-M-1, blaCTX-M-15, floR, strA, strB, catA, aadA, dfrA, tetA, tetR, tetY, mph(A), and TEM-105.
Multidrug-Resistant Enteropathogenic Escherichia coli Isolated from Diarrhoeic Calves, Milk, and Workers in Dairy Farms: A Potential Public Health Risk.
The study identified multiple AMR genes, including bla TEM, bla SHV, bla CTX-M-1, qnrA, qnrS, and bla VIM, in multidrug-resistant EPEC isolates from diarrhoeic calves, milk, and workers in Egyptian dairy farms.
A Selective Medium for Screening Ceftazidime/Avibactam Resistance in Carbapenem-Resistant Enterobacterales.
The study developed an SS CZA medium for screening CZA-resistant CRE isolates, demonstrating 100% sensitivity and specificity. The medium effectively distinguishes between CZA-resistant and -susceptible strains, with resistance determinants including blaNDM, blaKPC, blaCTX-M, blaTEM, blaSHV, blaOXA-23, blaIMP, and ampC.
Antimicrobial resistance genes, virulence markers and prophage sequences in Salmonella enterica serovar Enteritidis isolated in Tunisia using whole genome sequencing.
The study identified the blaTEM gene conferring ampicillin resistance and mutations in the gyrA gene leading to resistance against nalidixic acid and pefloxacin in Salmonella enterica serovar Enteritidis isolates from Tunisia.
Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection.
The study identified 27 genes associated with Klebsiella infection, including several AMR genes such as aac(6')-Ib-cr5, bla OXA-1, bla CTX-M-15, and bla TEM-1, as well as hypothetical proteins and transposases. These genes were found to be associated with infection, some of which were mediated by gut dominance.
Comparison of the Treatment Outcome of Piperacillin-Tazobactam versus Carbapenems for Patients with Bacteremia Caused by Extended-Spectrum beta-lactamase-Producing Escherichia coli in Areas with Low Frequency of Coproduction of OXA-1: a Preliminary Analysis.
The study found that piperacillin-tazobactam (TZP) may be as effective as carbapenems for treating non-severe cases of ESBL-producing E. coli bacteremia in areas with low frequency of OXA-1 co-production. The most common beta-lactamase identified was bla CTX-M-27, followed by bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, and bla CTX-M-8. Only a small percentage of isolates carried bla OXA-1, which is associated with reduced susceptibility to TZP.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
Characterization and Fitness Cost of Tn7100, a Novel Integrative and Conjugative Element Conferring Multidrug Resistance in Haemophilus influenzae.
The study identifies Tn7100, a novel integrative and conjugative element carrying six resistance genes: blaTEM-1B, catA2, aac(6')-Im, aph(2'')-Ib, mef(E), and mel, which confer resistance to multiple antibiotics in Haemophilus influenzae.
Large-Scale Studies on Antimicrobial Resistance and Molecular Characterization of Escherichia coli from Food Animals in Developed Areas of Eastern China.
The study identified mcr-1, tet(X4), and blaNDM-5 genes in Escherichia coli from food animals in eastern China, highlighting their role in resistance to colistin, tigecycline, and meropenem, respectively. These genes were found to be transferable via plasmids, emphasizing the potential for spread of antimicrobial resistance.
Occurrence and distribution of extended-spectrum beta-lactamase in clinical Escherichia coli isolates at Ho Teaching Hospital in Ghana.
The study identified blaTEM-1, blaCTXM-1, blaSHV-73, and TOHO-1 as the primary ESBL genes in E. coli isolates, with blaTEM-1 being the most prevalent. Multiple ESBL gene carriage was observed, indicating complex resistance mechanisms.
Within-farm dynamics of ESBL-producing Escherichia coli in dairy cattle: Resistance profiles and molecular characterization by long-read whole-genome sequencing.
The study identified multiple ESBL-encoding genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, and bla SHV-12, as well as carbapenemase gene bla NDM-1, in ESBL-producing E. coli isolates from dairy cattle farms. These genes were associated with resistance to various beta-lactam antibiotics. Additionally, several other AMR genes such as aadA2, ant(3")-Ia, aph(3')-Ia, dfrA12, sul3, cmlA1, and others were identified, contributing to resistance against aminoglycosides, trimethoprim, sulfamethoxazole, and chloramphenicol. Mutations in gyrA, parC, and parE were linked to fluoroquinolone resistance.
Whole genome sequencing of the multidrug-resistant Chryseobacterium indologenes isolated from a patient in Brazil.
The study identified multiple antibiotic resistance genes and mutations in a multidrug-resistant Chryseobacterium indologenes strain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and efflux pumps, contributing to resistance against various antibiotics.
Ultrasensitive and rapid identification of ESRI developer- and piperacillin/tazobactam-resistant Escherichia coli by the MALDIpiptaz test.
The study developed the MALDIpiptaz test for rapid detection of piperacillin/tazobactam (P/T)-resistant and ESRI developer Escherichia coli. The test uses MALDI-TOF MS and machine learning algorithms to classify isolates accurately and quickly.
Rapid Detection of Beta-Lactamases Genes among Enterobacterales in Urine Samples by Using Real-Time PCR.
The study developed a real-time PCR system to detect beta-lactamase genes (blaSHV-12, blaTEM, blaCTX-M-15, blaCTX-M-9, blaCMY-2, blaOXA-48, and blaNDM-1) in Enterobacterales strains from urine samples, demonstrating high sensitivity and specificity.
Genomic surveillance of Salmonella spp. in the Philippines during 2013-2014.
The study characterized various AMR genes and mutations in Salmonella isolates from the Philippines, highlighting the presence of ESBL genes, plasmid-mediated quinolone resistance genes, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Carbapenem-Resistant Organisms Isolated in Surgical Site Infections in Benin: A Public Health Problem.
The study identified carbapenem-resistant organisms in surgical site infections in Benin, highlighting the presence of bla CTX-M-1, bla TEM-1, bla OXA-48, bla NDM, and bla VIM genes, which confer resistance to multiple beta-lactam antibiotics.
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil.
The study characterizes antimicrobial resistance (AMR) genes and mutations in various Salmonella serovars associated with poultry in Brazil, emphasizing the emergence of multidrug-resistant (MDR) strains. Key findings include the identification of AMR genes such as blaCTX-M-2, blaTEM-1B, aac(3)-lla, aac(3)-lld, aadA1, aadA2, aph(6)-ld, dfrA1, floR, mrc-1, strA, strB, sul1, sul2, tet(A), tet(B), and others, which confer resistance to multiple antibiotics.
High Prevalence of Beta-Lactam-Resistant Escherichia coli in South Australian Grey-Headed Flying Fox Pups (Pteropus poliocephalus).
The study identified various beta-lactam-resistant Escherichia coli strains in South Australian grey-headed flying fox pups, including resistance genes such as blaTEM-1B, blaTEM-1C, blaTEM-33, blaCMY-2, dfrA17, aadA5, dfrA5, sul2, tet(A), tet(B), and catA1.
High Prevalence of Beta-Lactam-Resistant Escherichia coli in South Australian Grey-Headed Flying Fox Pups (Pteropus poliocephalus).
The study identified various beta-lactam-resistant Escherichia coli strains in South Australian grey-headed flying fox pups, including resistance genes such as blaTEM-1B, blaTEM-1C, blaTEM-33, blaCMY-2, dfrA17, aadA5, dfrA5, sul2, tet(A), tet(B), and catA1.
High Prevalence of Beta-Lactam-Resistant Escherichia coli in South Australian Grey-Headed Flying Fox Pups (Pteropus poliocephalus).
The study identified various beta-lactam-resistant Escherichia coli strains in South Australian grey-headed flying fox pups, including resistance genes such as blaTEM-1B, blaTEM-1C, blaTEM-33, blaCMY-2, dfrA17, aadA5, dfrA5, sul2, tet(A), tet(B), and catA1.
Prevalence and Molecular Characterization of Extended-Spectrum β-Lactamases and AmpC β-lactamase-Producing Enterobacteriaceae among Human, Cattle, and Poultry.
The study identified blaSHV, blaTEM, blaCTX-M, blaFOX, blaDHA, and blaACC genes as the primary contributors to extended-spectrum beta-lactamase and AmpC beta-lactamase production in Enterobacteriaceae isolated from humans, cattle, and poultry in Egypt.
Tigecycline-resistant Escherichia coli ST761 carrying tet(X4) in a pig farm, China.
The study identifies tet(X4) as a major cause of tigecycline resistance in E. coli ST761 isolates from a pig farm in China. The gene is located on a hybrid plasmid and is part of a multidrug resistance region that includes other resistance genes such as blaTEM-1, tet(A), tet(M), floR, qnrS1, sul3, dfrA5, and mef(B).
Genomic characterization of invasive typhoidal and non-typhoidal Salmonella in southwestern Nigeria.
The study identified multiple antibiotic resistance genes and mutations in invasive Salmonella isolates from Nigeria, highlighting the prevalence of multidrug-resistant S. Typhi 3.1.1 and other serovars carrying resistance determinants such as blaTEM-1, aph(3')-Ib, catA1, dfrA14, sul2, tetA, and qnrB19.
Detection of tem-1 and class-1 integrons in multidrug resistant uropathogens from HIV patients with asymptomatic bacteriuria in a Tertiary Care Hospital, SouthWest Nigeria.
The study identified blaTEM-1 as a common gene encoding resistance to ampicillin and penicillin in multidrug-resistant uropathogens from HIV patients with asymptomatic bacteriuria.
Dynamics of Genotypic and Phenotypic Antibiotic Resistance in a Conventional Wastewater Treatment Plant in 2 Years.
The study identified several AMR genes, including beta-lactamases (bla TEM, bla CTX-M-1, bla OXA-1), aminoglycoside resistance genes (strA, strB), sulfonamide resistance genes (sul1, sul2), and tetracycline resistance gene (tetA), in multidrug-resistant bacteria within a wastewater treatment plant over two years.
Whole-Genome Sequencing Reveals Diversity of Carbapenem-Resistant Pseudomonas aeruginosa Collected through CDC's Emerging Infections Program, United States, 2016-2018.
Urban rats as carriers of invasive Salmonella Typhimurium sequence type 313, Kisangani, Democratic Republic of Congo.
The study identified multidrug-resistant Salmonella Typhimurium ST313 in urban rats in Kisangani, Democratic Republic of Congo, highlighting their potential role as reservoirs of invasive Salmonella. The resistant isolates carried genes such as blaTEM-1, strA, strB, ant(3')-Ia, aac(3')-IId, sul1, sul2, dfrA1, tetB, and catA10, conferring resistance to multiple antibiotics.
Broad-Spectrum Inhibitors against Class A, B, and C Type β-Lactamases to Block the Hydrolysis against Antibiotics: Kinetics and Structural Characterization.
The study identifies three novel broad-spectrum inhibitors (D63, D2148, and D2573) effective against class A, B, and C β-lactamases, demonstrating reduced MIC and improved enzyme inhibition compared to existing inhibitors like avibactam.
Occurrence of Shiga toxin-producing Escherichia coli carrying antimicrobial resistance genes in sheep on smallholdings in Bangladesh.
The study identified the presence of antimicrobial resistance genes bla TEM, sul1, and sul2 in Shiga toxin-producing Escherichia coli (STEC) isolates from sheep in Bangladesh.
Molecular epidemiology and antibiotic resistance profiles of invasive Haemophilus influenzae from Norway 2017-2021.
The study identified bla TEM–1, rPBP3, catA2, tet(B), sul2, aph(3')-Ia, strA, and strB as significant antibiotic resistance genes in invasive Haemophilus influenzae isolates from Norway. Mutations in PBP3, GyrA, and ParC were also associated with resistance to beta-lactams and quinolones.
Carbapenemase- and Colistin Resistant Escherichia coli Strains from Children in China: High Genetic Diversity and First Report of bla (NDM-5), bla (CTX-M-65), bla (OXA-10), bla (TEM-1), and mcr-1.1 Genes Co-Occurrence in E. coli ST156.
Genomic analysis of plasmid content in food isolates of E. coli strongly supports its role as a reservoir for the horizontal transfer of virulence and antibiotic resistance genes.
The study identifies several antibiotic resistance genes in plasmids from food isolates of E. coli, including beta-lactamases (bla CTX-M-55, bla TEM-1, bla SHV-12, bla LAP-2, bla HERA-3, bla CMY-2, bla CTX-M-15, bla CTX-M-65, bla TEM-135, bla TEM-214, bla TEM-215), colistin resistance genes (mcr-1.1, mcr-9.1), aminoglycoside resistance genes (aph(6)-Id, aac(3)-IId, aadA2), sulfonamide resistance genes (sul1, sul2, sul3), and tetracycline resistance gene (tet(A)).
Genomic Analysis of Shiga Toxin-Producing E. coli O157 Cattle and Clinical Isolates from Alberta, Canada.
The study identified eight antimicrobial resistance gene cassettes (ARCs) in 14 isolates, with streptomycin resistance genes (aadA1, aadA2, ant(3'')-Ia, and aph(3'')-Ib) being the most prevalent. Other resistance genes included sul1, sul2, tet(A), tet(B), and beta-lactam resistance genes (blaTEM-1B and blaTEM-1C).
Genomic Analysis of Shiga Toxin-Producing E. coli O157 Cattle and Clinical Isolates from Alberta, Canada.
The study identified eight antimicrobial resistance gene cassettes (ARCs) in 14 isolates, with streptomycin resistance genes (aadA1, aadA2, ant(3'')-Ia, and aph(3'')-Ib) being the most prevalent. Other resistance genes included sul1, sul2, tet(A), tet(B), and beta-lactam resistance genes (blaTEM-1B and blaTEM-1C).
WGS-Based Lineage and Antimicrobial Resistance Pattern of Salmonella Typhimurium Isolated during 2000-2017 in Peru.
The study identifies 63 different AMR genes in 90 S. Typhimurium isolates from Peru, including beta-lactamases (blaTEM-181, blaSHV-12, blaSHV-134, blaCTX-M-15), quinolone resistance genes (qnrB5, qnrB19, qnrE2), tetracycline resistance genes (tetA, tetD, tetR), sulfonamide resistance genes (sul3), dihydrofolate reductase (dfrA1, dfrA12), florfenicol resistance gene (floR), lincomycin resistance gene (linG), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aadA2), colistin resistance gene (mcr-1), and fosfomycin resistance gene (fosA3).
Phylotypic Profiling, Distribution of Pathogenicity Island Markers, and Antimicrobial Susceptibility of Escherichia coli Isolated from Retail Chicken Meat and Humans.
The study identified several antimicrobial resistance genes, including sul2, blaTEM, qnrA, dfrA1, and aphA1, in Escherichia coli isolates from retail chicken meat and human urinary tract infections. These genes conferred resistance to various antibiotics such as penicillin, sulfonamides, quinolones, and aminoglycosides.
Molecular Typing Reveals Environmental Dispersion of Antibiotic-Resistant Enterococci under Anthropogenic Pressure.
The study identified multiple antibiotic resistance genes in Enterococcus isolates from various aquatic environments, highlighting the role of anthropogenic pressure in the spread of antibiotic-resistant enterococci.
Occurrence of Antimicrobial-Resistant Escherichia coli in Marine Mammals of the North and Baltic Seas: Sentinels for Human Health.
The study identified antimicrobial-resistant Escherichia coli in marine mammals from the North and Baltic Seas, highlighting the presence of resistance genes such as blaTEM, strA, strB, aadA1, sul1, sul2, tet(A), tet(B), tet(D), qnrS, floR, catA1, blaOXA-1-like, blaSHV, and blaCMY-2.
Molecular Mechanisms of Drug Resistance and Epidemiology of Multidrug-Resistant Variants of Neisseria gonorrhoeae.
The paper discusses the development and evaluation of new antimicrobial agents against Neisseria gonorrhoeae, highlighting the importance of monitoring resistance mechanisms such as mutations in GyrA and ParC that confer resistance to fluoroquinolones.
Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock.
The study identified qnrS1 as a quinolone resistance gene present in both broiler chicken and human samples, indicating potential transmission between these hosts.
Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Strains Recovered from Chilean Hospitals Reveals Lineages Specific to South America and Multiple Routes for Acquisition of Antibiotic Resistance Genes.
The study identifies various AMR genes in carbapenem-resistant Acinetobacter baumannii strains from Chile, including blaTEM, aacC2, aphA6, sul1, sul2, catA1, tetA(A), aadA1, dfrA1, strAB, cmlB1, floR, oxa58, and oxa23, highlighting the diversity of resistance mechanisms and the role of mobile genetic elements in their dissemination.
Antimicrobial resistance of Salmonella Indiana from retail chickens in China and emergence of an mcr-1-harboring isolate with concurrent resistance to ciprofloxacin, cefotaxime, and colistin.
The study identified multiple AMR genes in Salmonella Indiana isolates, including bla CTX-M-65, bla CTX-M-14, bla CTX-M-27, bla CTX-M-28, bla CTX-M-79, aac(6')-Ib-cr, oqxAB, and mcr-1, which contribute to resistance against various antibiotics.
Clinical Efficacy, Antibiotic Resistance Genes, Virulence Factors and Outcome of Hospital-Acquired Pneumonia Induced by Klebsiella pneumoniae Carbapenemase 2-Producing with Tigecycline Treatment in the ICU.
The study identified several antibiotic resistance genes, including blaKPC-2, blaSHV, blaCTX-M, blaTEM, and aac3iia, which are associated with resistance to various antibiotics. Additionally, virulence factors such as AREO-iutA and Capsule-wzc were found to be independently associated with mortality in patients with KPC-KP infections.
Clinical Efficacy, Antibiotic Resistance Genes, Virulence Factors and Outcome of Hospital-Acquired Pneumonia Induced by Klebsiella pneumoniae Carbapenemase 2-Producing with Tigecycline Treatment in the ICU.
The study identified several antibiotic resistance genes, including blaKPC-2, blaSHV, blaCTX-M, blaTEM, and aac3iia, which are associated with resistance to various antibiotics. Additionally, virulence factors such as AREO-iutA and Capsule-wzc were found to be independently associated with mortality in patients with KPC-KP infections.
Phenotypic and genotypic detection of extended spectrum beta lactamase enzyme in Klebsiella pneumoniae.
The study identified blaSHV and blaTEM genes as the predominant ESBL genes in Klebsiella pneumoniae isolates, with blaSHV being more prevalent.
Draft Genome Sequence of Two Salmonella enterica Subspecies enterica Serovar Minnesota Strains Harboring Mcr-1.1 Gene Isolated from Chicken Meat in Saudi Arabia.
Two Salmonella enterica subsp. enterica serovar Minnesota strains carrying the mcr-1.1 gene, which confers colistin resistance, were isolated from chicken meat in Saudi Arabia. Additional resistance genes including sul2, tetA, blaTEM-1B, qnrB19, aac(6')-Iaa, aac(3)-IV, and floR were also identified.
Typeable ampicillin-resistant Haemophilus influenzae strains in Tunisian's children.
The study identifies bla TEM-1 and ftsI as key genes responsible for ampicillin resistance in Haemophilus influenzae strains in Tunisia.
Epidemiological characteristics an outbreak of ST11 multidrug-resistant and hypervirulent Klebsiella pneumoniae in Anhui, China.
What Is in the Salad? Escherichia coli and Antibiotic Resistance in Lettuce Irrigated with Various Water Sources in Ghana.
The study identified Escherichia coli contamination in lettuce irrigated with various water sources in Ghana, with a notable presence of the blaTEM gene conferring resistance to cephalosporins.
Evolution of Beta-Lactamases in Urinary Klebsiella pneumoniae Isolates from Croatia; from Extended-Spectrum Beta-Lactamases to Carbapenemases and Colistin Resistance.
The study identified the evolution of beta-lactamases in urinary Klebsiella pneumoniae isolates from Croatia, highlighting the emergence of CTX-M-15, OXA-48, and KPC-2 beta-lactamases, along with the increasing resistance to carbapenems and colistin.
Whole genome sequencing of OXA-232-producing wzi93-KL112-O1 carbapenem-resistant Klebsiella pneumoniae in human bloodstream infection co-harboring chromosomal ISEcp1-based bla (CTX-M-15) and one rmpA2-associated virulence plasmid.
The study characterizes an OXA-232-producing ST15 CRKP strain with a multidrug-resistant profile, harboring chromosomal bla CTX-M-15 and plasmid-mediated bla OXA-232, along with other resistance genes such as strAB, rmtF, sul2, dfrA14, qnrB1, arr-2, and catB. Mutations in gyrA (S83F) and parC (S80I) contribute to fluoroquinolone resistance.
Whole-Genome Sequencing of Neisseria gonorrhoeae Isolates with Antimicrobial Resistance Plasmids from a Homeless Community in Colombia.
The study identified two TEM beta-lactamase genes, blaTEM-P14S and blaTEM-135, in Neisseria gonorrhoeae isolates from a homeless community in Colombia, highlighting their association with multidrug resistance.
Whole-Genome Sequencing of Neisseria gonorrhoeae Isolates with Antimicrobial Resistance Plasmids from a Homeless Community in Colombia.
The study identified two TEM beta-lactamase genes, blaTEM-P14S and blaTEM-135, in Neisseria gonorrhoeae isolates from a homeless community in Colombia, highlighting their association with multidrug resistance.
Genome-associations of extended-spectrum ß-lactamase producing (ESBL) or AmpC producing E. coli in small and medium pig farms from Khon Kaen province, Thailand.
The study identifies various AMR genes in ESBL and/or AmpC-producing E. coli from small and medium pig farms in Thailand, highlighting the co-occurrence of resistance genes conferring resistance to critically important antimicrobials.
Prevalence, antibiotic profile, virulence determinants, ESBLs, and non-β-lactam encoding genes of MDR Proteus spp. isolated from infected dogs.
The study identified multiple AMR genes in MDR Proteus spp. isolated from dogs, including bla TEM, bla SHV, bla CTX-M, bla OXA-1, sul1, tetA, aadA1, qnrA, intI1, ure C, zap A, and rsb A. These genes conferred resistance to various antibiotics such as penicillins, cephalosporins, sulfonamides, tetracyclines, quinolones, and aminoglycosides.
Human pandemic K27-ST392 CTX-M-15 extended-spectrum beta-lactamase-positive Klebsiella pneumoniae: A one health clone threatening companion animals.
The study identifies a multidrug-resistant K. pneumoniae strain (LCKp01) carrying the bla CTX-M-15 gene and other clinically important AMR genes, highlighting the global spread of this clone in both human and animal populations.
Salmonella Derby from pig production chain over a 10-year period: antimicrobial resistance, biofilm formation, and genetic relatedness.
The study identified resistance genes blaTEM, aadA, tetA, and floR in Salmonella Derby isolates, which conferred resistance to ampicillin, streptomycin/spectinomycin, tetracycline, and florfenicol, respectively.
Dominance of phage particles carrying antibiotic resistance genes in the viromes of retail food sources.
The study identifies and characterizes the presence of antibiotic resistance genes (ARGs) in phage particles from retail food sources, demonstrating that these phages can carry and potentially transfer resistance genes such as bla TEM, sul1, and tetW.
Antimicrobial Resistance Pattern, Clustering Mechanisms and Correlation Matrix of Drug-Resistant Escherichia coli in Black Bengal Goats in West Bengal, India.
The study identified several AMR genes in multidrug-resistant E. coli isolates from goats, including bla CTXM-1, bla AmpC, bla SHV, bla TEM, bla CMY-6, bla CITM, bla NDM-5, qnr B, qnr S, aac(6')-Ib-cr, tet A, tet B, sul 1, and the acrAB efflux pump system.
Occurrence and Molecular Characterization of Multidrug-Resistant Vegetable-Borne Listeria monocytogenes Isolates.
The study identified multiple antibiotic resistance genes in vegetable-borne L. monocytogenes isolates, including SulI, tetA, tetM, and blaTEM, indicating a high prevalence of multidrug-resistant strains.
Occurrence and Biological Cost of mcr-1-Carrying Plasmids Co-harbouring Beta-Lactamase Resistance Genes in Zoonotic Pathogens from Intensive Animal Production.
The study identifies mcr-1 and various beta-lactamase genes, including bla TEM-1, bla CTX-M-1, and bla CTX-M-15, in E. coli and Salmonella enterica isolates from intensive animal production. These genes confer resistance to colistin and beta-lactam antibiotics, highlighting the co-occurrence of resistance mechanisms in zoonotic pathogens.
Emergence of a Novel Lineage and Wide Spread of a bla(CTX-M-15)/IncHI2/ST1 Plasmid among Nosocomial Enterobacter in Guadeloupe.
The study identifies the bla CTX-M-15 gene as the most prevalent ESBL determinant in ESBL-producing Enterobacter cloacae complex isolates, along with the IncHI2/ST1 plasmid. It also reports the presence of other resistance genes such as mcr-9, aac(3)-IIa, aac(6′)-Ib-cr, aph(3″)-Ib, aph(6)-Id, bla OXA-1, bla TEM-1B, qnrB1, fosA, sul2, tet(A), dfrA14, ars, mer, tni, and the ter operon.
Haemophilus influenzae Carriage among Healthy Children in Portugal, 2015-2019.
The study identified blaTEM-1 and blaTEM-82 genes in β-lactamase-producing Haemophilus influenzae isolates, contributing to ampicillin resistance.
Haemophilus influenzae Carriage among Healthy Children in Portugal, 2015-2019.
The study identified blaTEM-1 and blaTEM-82 genes in β-lactamase-producing Haemophilus influenzae isolates, contributing to ampicillin resistance.
Antibiotic Susceptibility Profiles and Resistance Mechanisms to β-Lactams and Polymyxins of Escherichia coli from Broilers Raised under Intensive and Extensive Production Systems.
The study identifies several β-lactamase genes, including SHV-12, CTX-M group variants, TEM, OXA, and PMAβ, as well as the mcr-1 gene responsible for polymyxin resistance in E. coli isolates from broilers raised in intensive and extensive systems. The prevalence of reduced susceptibility to antibiotics is higher in isolates from the intensive system.
Whole genome sequencing and characteristics of extended-spectrum beta-lactamase producing Escherichia coli isolated from poultry farms in Banaskantha, India.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla TEM, bla SHV, bla OXA, and bla CTX-M subtypes, along with plasmid-mediated AMR genes such as qnrS1, tetA, dfrA14, sul2, aph(3")-lb, aph(6)-ld, and Aph(3')-la in ESBL-producing E. coli isolates from poultry farms in India.
Prevalence and antibiotic resistance of Staphylococcus aureus and Escherichia coli isolated from raw milk in East Java, Indonesia.
The study identified the presence of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA) and blaTEM gene in extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolated from raw milk in East Java, Indonesia.
Pathogenome comparison and global phylogeny of Escherichia coli ST1485 strains.
The study identifies multiple antibiotic resistance genes, including blaTEM-1, aph(3')-Ib, aph(6)-Id, sul2, dfrA14, and mcr-1, in Escherichia coli ST1485 strains, highlighting their multidrug-resistant nature and potential zoonotic risk.
Multistate reptile- and amphibian-associated salmonellosis outbreaks in humans, United States, 2009-2018.
The study identified various AMR genes and mutations in Salmonella isolates from multistate reptile- and amphibian-associated salmonellosis outbreaks in the United States, including bla CMY-2, qnrB19, qnrS1, bla TEM-116, bla TEM-1C, bla TEM-1B, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, dfrA12, sul1, sul3, floR, tet(A), and sul2, which conferred resistance to multiple antibiotics such as ciprofloxacin, ceftriaxone, ampicillin, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole, chloramphenicol, and tetracycline.
Multistate reptile- and amphibian-associated salmonellosis outbreaks in humans, United States, 2009-2018.
The study identified various AMR genes and mutations in Salmonella isolates from multistate reptile- and amphibian-associated salmonellosis outbreaks in the United States, including bla CMY-2, qnrB19, qnrS1, bla TEM-116, bla TEM-1C, bla TEM-1B, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, dfrA12, sul1, sul3, floR, tet(A), and sul2, which conferred resistance to multiple antibiotics such as ciprofloxacin, ceftriaxone, ampicillin, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole, chloramphenicol, and tetracycline.
Multistate reptile- and amphibian-associated salmonellosis outbreaks in humans, United States, 2009-2018.
The study identified various AMR genes and mutations in Salmonella isolates from multistate reptile- and amphibian-associated salmonellosis outbreaks in the United States, including bla CMY-2, qnrB19, qnrS1, bla TEM-116, bla TEM-1C, bla TEM-1B, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, dfrA12, sul1, sul3, floR, tet(A), and sul2, which conferred resistance to multiple antibiotics such as ciprofloxacin, ceftriaxone, ampicillin, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole, chloramphenicol, and tetracycline.
Alarming Antibiotic Resistance of Lactobacilli Isolated from Probiotic Preparations and Dietary Supplements.
The study identified vancomycin resistance gene vanX, ciprofloxacin resistance gene parC, extended-spectrum beta-lactamase gene blaTEM, and tetracycline resistance gene tetK in Lactobacillus isolates from probiotic products.
The Impact of Chlorine Disinfection of Hospital Wastewater on Clonal Similarity and ESBL-Production in Selected Bacteria of the Family Enterobacteriaceae.
Chlorine-based disinfection promotes the survival of ESBL-producing bacteria and/or the transmission of genetic determinants of AMR, increasing the proportion of ESBL-producing Enterobacteriaceae in disinfected wastewater.
Dissemination of High-Risk Clones Enterobacterales among Bulgarian Fecal Carriage Isolates.
The study identified several AMR genes, including bla CTX-M-15, bla CTX-M-3, bla CTX-M-27, bla CTX-M-14, bla CTX-M-9, bla SHV-1, bla SHV-11, bla TEM-1, bla NDM-1, bla KPC-2, bla CMY-4, bla DHA-1, and bla CMY-2, which confer resistance to various beta-lactam antibiotics. High-risk clones such as ST11, ST258, and ST15 were found to be prevalent among Klebsiella pneumoniae isolates, while ST131 was the most common among E. coli isolates.
Current Susceptibility Surveillance and Distribution of Antimicrobial Resistance in N. gonorrheae within WHO Regions.
The study characterizes the molecular mechanisms of antimicrobial resistance in Neisseria gonorrhoeae, highlighting the role of specific genes and mutations in conferring resistance to various antibiotics, including extended-spectrum cephalosporins, fluoroquinolones, and macrolides.
A First Report of Molecular Typing, Virulence Traits, and Phenotypic and Genotypic Resistance Patterns of Newly Emerging XDR and MDR Aeromonas veronii in Mugil seheli.
The study identified XDR and MDR Aeromonas veronii strains in Mugil seheli carrying resistance genes bla TEM, bla CTX-M, bla SHV, tet A, aad A1, and sul 1.
Identification of KPC-112 from an ST15 Klebsiella pneumoniae Strain Conferring Resistance to Ceftazidime-Avibactam.
The study identifies a novel KPC variant, KPC-112, which confers resistance to ceftazidime-avibactam. Additionally, various other resistance genes and mutations were characterized, contributing to multidrug resistance in the isolate.
Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.
The study identified ESBL-producing E. coli in river water in northern Thailand, with bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27 being the most prevalent beta-lactamase genes. Additionally, mcr-1.1 and mcr-3.4 genes were found to confer resistance to colistin. Various other resistance genes were also characterized, including aac(3)-IId, aadA5, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, aac(6′)-Ib-cr, qnrS1, mdf(A), erm(B), mph(A), floR, sul2, sul3, tet(A), tet(X), tet(M), dfrA12, dfrA14, dfrA17, cmlA1, catA2, lnu(F), and erm(42).
Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.
The study identified ESBL-producing E. coli in river water in northern Thailand, with bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27 being the most prevalent beta-lactamase genes. Additionally, mcr-1.1 and mcr-3.4 genes were found to confer resistance to colistin. Various other resistance genes were also characterized, including aac(3)-IId, aadA5, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, aac(6′)-Ib-cr, qnrS1, mdf(A), erm(B), mph(A), floR, sul2, sul3, tet(A), tet(X), tet(M), dfrA12, dfrA14, dfrA17, cmlA1, catA2, lnu(F), and erm(42).
Antimicrobial resistance and genomic characterization of Salmonella enterica serovar Senftenberg isolates in production animals from the United States.
The study characterized antimicrobial resistance genes and mutations in Salmonella enterica serovar Senftenberg isolates from production animals in the United States, identifying genes such as aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, blaTEM-1B, blaCMY-2, blaSHV-12, floR, catA2, qnrB2, aac(6')-Ib-cr, aadA1, aadA2, sul1, sul2, tetA, and mcr-9.1, along with mutations in gyrA and parC genes contributing to resistance against various antibiotics.
Phenotypic and genomic assessment of the potential threat of human spaceflight-relevant Staphylococcus capitis isolates under stress conditions.
All four Staphylococcus capitis strains were found to be resistant to fosfomycin, with no significant differences in antibiotic susceptibility among the strains.
Molecular Characterization and the Antimicrobial Resistance Profile of Salmonella spp. Isolated from Ready-to-Eat Foods in Ouagadougou, Burkina Faso.
The study identified several antimicrobial resistance genes in Salmonella isolates from ready-to-eat foods in Burkina Faso, including blaTEM, temB, sul1, sul2, aadA, tet(A), and tet(B). These genes confer resistance to various antibiotics such as ampicillin, cefoxitin, trimethoprim/sulfamethoxazole, and tetracycline.
Prevalence of extended spectrum Beta-Lactamase producing Klebsiella species from patients' specimens in a tertiary teaching hospital in Ile-Ife, Southwest Nigeria.
The study identified blaSHV, blaTEM, and blaCTX-M as the most prevalent ESBL genes in Klebsiella isolates, with blaSHV being the most common.
Can Stray Cats Be Reservoirs of Antimicrobial Resistance?
Stray cats can carry antibiotic-resistant E. coli with resistance genes blaTEM, blaCTX-M, tet(A), and tet(B), indicating their potential role in the spread of antimicrobial resistance in urban environments.
Characterization of Escherichia coli and other bacteria isolated from condemned broilers at a Danish abattoir.
The study identified several AMR genes in E. coli isolates from condemned broiler carcasses, including beta-lactamase genes (bla TEM-1B, bla TEM-1C, bla TEM-220, bla TEM-106, bla TEM-135, bla TEM-126, bla TEM-127), sulfonamide resistance gene (sul 2), aminoglycoside resistance genes (aph (6)-Id, aph (3")-Ib, aph (3')-Ia, aad A1, aad A5, aac (3)- Via), trimethoprim resistance genes (dfr A1, dfr A14, dfr A15, dfr A17), tetracycline resistance genes (tet (A), tet (B)), and a macrolide resistance gene (mdf (A)).
Characterization of Escherichia coli and other bacteria isolated from condemned broilers at a Danish abattoir.
The study identified several AMR genes in E. coli isolates from condemned broiler carcasses, including beta-lactamase genes (bla TEM-1B, bla TEM-1C, bla TEM-220, bla TEM-106, bla TEM-135, bla TEM-126, bla TEM-127), sulfonamide resistance gene (sul 2), aminoglycoside resistance genes (aph (6)-Id, aph (3")-Ib, aph (3')-Ia, aad A1, aad A5, aac (3)- Via), trimethoprim resistance genes (dfr A1, dfr A14, dfr A15, dfr A17), tetracycline resistance genes (tet (A), tet (B)), and a macrolide resistance gene (mdf (A)).
Characterization of Escherichia coli and other bacteria isolated from condemned broilers at a Danish abattoir.
The study identified several AMR genes in E. coli isolates from condemned broiler carcasses, including beta-lactamase genes (bla TEM-1B, bla TEM-1C, bla TEM-220, bla TEM-106, bla TEM-135, bla TEM-126, bla TEM-127), sulfonamide resistance gene (sul 2), aminoglycoside resistance genes (aph (6)-Id, aph (3")-Ib, aph (3')-Ia, aad A1, aad A5, aac (3)- Via), trimethoprim resistance genes (dfr A1, dfr A14, dfr A15, dfr A17), tetracycline resistance genes (tet (A), tet (B)), and a macrolide resistance gene (mdf (A)).
Characterization of Escherichia coli and other bacteria isolated from condemned broilers at a Danish abattoir.
The study identified several AMR genes in E. coli isolates from condemned broiler carcasses, including beta-lactamase genes (bla TEM-1B, bla TEM-1C, bla TEM-220, bla TEM-106, bla TEM-135, bla TEM-126, bla TEM-127), sulfonamide resistance gene (sul 2), aminoglycoside resistance genes (aph (6)-Id, aph (3")-Ib, aph (3')-Ia, aad A1, aad A5, aac (3)- Via), trimethoprim resistance genes (dfr A1, dfr A14, dfr A15, dfr A17), tetracycline resistance genes (tet (A), tet (B)), and a macrolide resistance gene (mdf (A)).
Characterization of Escherichia coli and other bacteria isolated from condemned broilers at a Danish abattoir.
The study identified several AMR genes in E. coli isolates from condemned broiler carcasses, including beta-lactamase genes (bla TEM-1B, bla TEM-1C, bla TEM-220, bla TEM-106, bla TEM-135, bla TEM-126, bla TEM-127), sulfonamide resistance gene (sul 2), aminoglycoside resistance genes (aph (6)-Id, aph (3")-Ib, aph (3')-Ia, aad A1, aad A5, aac (3)- Via), trimethoprim resistance genes (dfr A1, dfr A14, dfr A15, dfr A17), tetracycline resistance genes (tet (A), tet (B)), and a macrolide resistance gene (mdf (A)).
Characterization of Escherichia coli and other bacteria isolated from condemned broilers at a Danish abattoir.
The study identified several AMR genes in E. coli isolates from condemned broiler carcasses, including beta-lactamase genes (bla TEM-1B, bla TEM-1C, bla TEM-220, bla TEM-106, bla TEM-135, bla TEM-126, bla TEM-127), sulfonamide resistance gene (sul 2), aminoglycoside resistance genes (aph (6)-Id, aph (3")-Ib, aph (3')-Ia, aad A1, aad A5, aac (3)- Via), trimethoprim resistance genes (dfr A1, dfr A14, dfr A15, dfr A17), tetracycline resistance genes (tet (A), tet (B)), and a macrolide resistance gene (mdf (A)).
Characterization of Escherichia coli and other bacteria isolated from condemned broilers at a Danish abattoir.
The study identified several AMR genes in E. coli isolates from condemned broiler carcasses, including beta-lactamase genes (bla TEM-1B, bla TEM-1C, bla TEM-220, bla TEM-106, bla TEM-135, bla TEM-126, bla TEM-127), sulfonamide resistance gene (sul 2), aminoglycoside resistance genes (aph (6)-Id, aph (3")-Ib, aph (3')-Ia, aad A1, aad A5, aac (3)- Via), trimethoprim resistance genes (dfr A1, dfr A14, dfr A15, dfr A17), tetracycline resistance genes (tet (A), tet (B)), and a macrolide resistance gene (mdf (A)).
Examining the impact of zinc on horizontal gene transfer in Enterobacterales.
The study identified the transfer of the blaTEM-1B gene, which confers resistance to ampicillin, from an ESBL-producing E. coli donor to Salmonella recipient strains during conjugation.
Antimicrobial resistance, virulence associated genes and phylogenetic background versus plasmid replicon types: the possible associations in avian pathogenic Escherichia coli (APEC).
The study identified bla TEM, bla CTX, and bla OXA genes in 68.05% of the APEC strains, highlighting their role in antimicrobial resistance. bla CTX was significantly associated with phylogroup D and resistance to multiple antibiotics.
A Shigella sonnei clone with extensive drug resistance associated with waterborne outbreaks in China.
The study reports the emergence of XDR Shigella sonnei strains with cef R azi R and col R phenotypes associated with waterborne outbreaks in China, highlighting the role of plasmid-mediated AMR genes such as bla CTX-M-14, mphA, mcr-1, and others in the spread of multidrug resistance.
Characterisation and antibiotic resistance of Yersinia enterocolitica from various meat categories, South Africa.
The study identified blaTEM, cmlA, and tetB as the primary antimicrobial resistance genes in Y. enterocolitica isolates from meat products in South Africa, with high prevalence of resistance to ampicillin, cephalothin, and tetracycline.
Establishing a marine monitoring programme to assess antibiotic resistance: A case study from the Gulf Cooperation Council (GCC) region.
The study identified several AMR genes in E. coli isolates from the GCC marine environment, including bla TEM-1, bla CTX-M-15, qnrS1, tet, sul, and dfr, which conferred resistance to various antibiotics such as ampicillin, cefotaxime, ceftazidime, ciprofloxacin, tetracycline, sulfamethoxazole, and trimethoprim.
The hazard of carbapenemase (OXA-181)-producing Escherichia coli spreading in pig and veal calf holdings in Italy in the genomics era: Risk of spill over and spill back between humans and animals.
The study identifies multiple AMR genes, including bla OXA-181, bla TEM-1B, aac (3)-IId, aad A2, cml A1, dfr A12, mef (B), sul 3, tet (A), tet (M), incX3, incX1, incFII, qnr S1, aph (3″)-Ib, aph (6)-Id, flo R, lnu (F), sul 2, sul 3, tet (B), mph (A), mph (G), qnr B4, rmt B, and fos A3, in OXA-181-producing E. coli isolates from pigs and bovines in Italy. These genes confer resistance to various antibiotics, including carbapenems, cephalosporins, penicillins, aminoglycosides, trimethoprim, macrolides, sulfonamides, tetracyclines, fluoroquinolones, and fosfomycin.
Impact of international travel and diarrhea on gut microbiome and resistome dynamics.
The study identifies several antimicrobial resistance genes, including blaTEM-148, sul2, aph6, and tetA, in diarrheagenic Escherichia coli isolates from international travelers, highlighting the increased resistance gene diversity associated with diarrhea.
Isolation, Identification, and Genetic Characterization of Antibiotic Resistance of Salmonella Species Isolated from Chicken Farms.
The study identified several AMR genes in Salmonella isolates from chicken farms in Egypt, including blaTEM, blaSHV, ermB, ereA, and mphA, which conferred resistance to ampicillin, erythromycin, and lincomycin.
Prevalence, antimicrobial resistance, and staphylococcal toxin genes of bla(TEM-1a)-producing Staphylococcus aureus isolated from animals in Chongqing, China.
The study identified bla TEM-1a as a prevalent gene in Staphylococcus aureus isolates from animals in Chongqing, China, contributing to resistance against penicillin and ampicillin.
Molecular Characterization of Salmonella spp. Isolates from Wild Colombian Babilla (Caiman crocodilus fuscus) Isolated In Situ.
The study identified multiple antibiotic resistance genes in Salmonella isolates from wild Colombian babilla, including blaTEM, strB, sul1, blaCMY2, blaCTX-M, sul2, dfrA1, floR, and qnrD, indicating the potential of these reptiles as carriers of multidrug-resistant bacteria.
Genetic Relationship between Salmonella Isolates Recovered from Calves and Broilers Chickens in Kafr El-Sheikh City Using ERIC PCR.
The study identified the blaTEM gene as a determinant of beta-lactam resistance in multidrug-resistant Salmonella isolates from calves and broiler chickens in Egypt.
Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae in a Tertiary Hospital in Northern China.
The study identified bla KPC-2, bla GES, bla NDM-1, and bla IMP as the main carbapenemase genes in CRKP isolates. Additionally, various ESBL genes, aminoglycoside resistance genes, and PMQR genes were detected.
Characterization of virulence and antimicrobial resistance genes of Aeromonas media strain SD/21-15 from marine sediments in comparison with other Aeromonas spp.
The study characterized multiple antimicrobial resistance (AMR) genes in Aeromonas media strain SD/21-15, including beta-lactamases (bla MOX-9, bla OXA-427), carbapenemases (crp), polymyxin resistance genes (mcr, mcr-3, mcr-3.6), tetracycline resistance (tet(E)), quinolone resistance (qnrS2), and multidrug efflux pumps (mexB).
Mobile colistin resistance (MCR), extended-spectrum beta-lactamase (ESBL) and multidrug resistance monitoring in Escherichia coli (commensal and pathogenic) in pig farming: need of harmonized guidelines and clinical breakpoints.
The study identified mcr-1 and mcr-4 genes conferring colistin resistance, along with blaTEM-1B, aph(3")-Ib, aph(6)-Id, sul2, and tet(A) genes responsible for resistance to various antibiotics in E. coli isolates from pig farming.
Rothia nasimurium as a Cause of Disease: First Isolation from Farmed Chickens.
Rothia nasimurium was isolated from chickens for the first time and found to exhibit multidrug resistance, carrying 13 resistance genes including bla TEM, bla CTX-M, mecA, sul1, sul2, sul3, aac(6′)-Ib, gyrA, aph(3′)-Ia, tet(A), tetM, and ermB.
Rothia nasimurium as a Cause of Disease: First Isolation from Farmed Chickens.
Rothia nasimurium was isolated from chickens for the first time and found to exhibit multidrug resistance, carrying 13 resistance genes including bla TEM, bla CTX-M, mecA, sul1, sul2, sul3, aac(6′)-Ib, gyrA, aph(3′)-Ia, tet(A), tetM, and ermB.
Molecular Epidemiology of Antimicrobial Resistance and Virulence Profiles of Escherichia coli, Salmonella spp., and Vibrio spp. Isolated from Coastal Seawater for Aquaculture.
The study identified several AMR genes, including blaTEM, tetA, qnrS, strA, and floR, in Escherichia coli, Salmonella spp., and Vibrio spp. isolates from coastal seawater in Thailand. These genes conferred resistance to various antibiotics such as ampicillin, tetracycline, fluoroquinolones, streptomycin, and chloramphenicol.
Prevalence of Antibiotic-Resistant E. coli Strains in a Local Farm and Packing Facilities of Honeydew Melon in Hermosillo, Sonora, Mexico.
The study identified the presence of antibiotic-resistant E. coli strains in irrigation water, discarded melons, and packing facilities in a Honeydew melon farm in Hermosillo, Sonora. The most prevalent ESBL gene was bla TEM, and non-ESBL genes qepA and aac(6')-lb-cr were also detected.
Genomic Analysis of Klebsiella pneumoniae ST258 Strain Coproducing KPC-2 and CTX-M-14 Isolated from Poultry in the Brazilian Amazon Region.
The study characterizes a multidrug-resistant Klebsiella pneumoniae ST258 strain (KP411) isolated from poultry in the Brazilian Amazon, which carries several AMR genes including blaKPC-2, blaCTX-M-14, and others, highlighting the potential of food-producing animals as reservoirs of MDR clones.
First Report of Potentially Pathogenic Klebsiella pneumoniae from Serotype K2 in Mollusk Tegillarca granosa and Genetic Diversity of Klebsiella pneumoniae in 14 Species of Edible Aquatic Animals.
The study reports the presence of tetracycline resistance in Klebsiella pneumoniae isolates from various aquatic animals, highlighting the potential risk of antimicrobial resistance in food sources.
A Familiar Outbreak of Monophasic Salmonella serovar Typhimurium (ST34) Involving Three Dogs and Their Owner's Children.
The study identified AMR genes sul2, tetB, and blaTEM-1B in a monophasic Salmonella Typhimurium ST34 outbreak involving humans and dogs.
Paratype: a genotyping tool for Salmonella Paratyphi A reveals its global genomic diversity.
Paratype: a genotyping tool for Salmonella Paratyphi A reveals its global genomic diversity.
Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome.
The study found that prolonged amoxicillin treatment leads to an increase in the abundance and diversity of antimicrobial resistance genes (ARGs) in the gut microbiome, particularly beta-lactamase genes such as cfxA and its variants, as well as tetracycline and macrolide resistance genes.
Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome.
The study found that prolonged amoxicillin treatment leads to an increase in the abundance and diversity of antimicrobial resistance genes (ARGs) in the gut microbiome, particularly beta-lactamase genes such as cfxA and its variants, as well as tetracycline and macrolide resistance genes.
Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome.
The study found that prolonged amoxicillin treatment leads to an increase in the abundance and diversity of antimicrobial resistance genes (ARGs) in the gut microbiome, particularly beta-lactamase genes such as cfxA and its variants, as well as tetracycline and macrolide resistance genes.
Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome.
The study found that prolonged amoxicillin treatment leads to an increase in the abundance and diversity of antimicrobial resistance genes (ARGs) in the gut microbiome, particularly beta-lactamase genes such as cfxA and its variants, as well as tetracycline and macrolide resistance genes.
Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome.
The study found that prolonged amoxicillin treatment leads to an increase in the abundance and diversity of antimicrobial resistance genes (ARGs) in the gut microbiome, particularly beta-lactamase genes such as cfxA and its variants, as well as tetracycline and macrolide resistance genes.
Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome.
The study found that prolonged amoxicillin treatment leads to an increase in the abundance and diversity of antimicrobial resistance genes (ARGs) in the gut microbiome, particularly beta-lactamase genes such as cfxA and its variants, as well as tetracycline and macrolide resistance genes.
Intestinal colonization with ESBL-producing Klebsiella pneumoniae in healthy rural villager: A genomic surveillance study in China, 2015-2017.
The study identified multiple ESBL genes, including bla TEM-1B, bla CTX-M-14, and bla SHV-11, along with other resistance genes such as qnrS1, sul1, aac(6')-Ib-cr, aadA16, aph(3')-Ib, tet(A), and mcr-1, contributing to multidrug resistance in ESBL-producing Klebsiella pneumoniae isolates from healthy rural villagers in China.
Prevalence and multidrug resistance of Enterococcus species isolated from chickens at slaughterhouses in Nakhon Ratchasima Province, Thailand.
The study identified the presence of ESBL-TEM, bla TEM, intI1, mrc–1, and vanA genes in multidrug-resistant Enterococcus isolates from chickens and their meat products in Nakhon Ratchasima Province, Thailand.
Genotypic characterization of extended-spectrum beta-lactamase producing urinary isolates among pregnant women in Ho municipality, Ghana.
The study identified bla TEM, bla CTX-M, and bla SHV genes as the primary mechanisms of extended-spectrum beta-lactamase (ESBL) production in urinary isolates from pregnant women in Ho municipality, Ghana.
Genomic Characterization of ESBL/AmpC-Producing Escherichia coli in Stray Dogs Sheltered in Yangzhou, China.
The study identified several beta-lactamase genes, including bla CTX-M-15, bla CTX-M-55, and others, along with additional resistance genes such as tet(A), qnrS1, and oqxAB, contributing to multidrug resistance in ESBL/AmpC-producing E. coli isolated from stray dogs in Yangzhou, China.
Genomic Characterization of ESBL/AmpC-Producing Escherichia coli in Stray Dogs Sheltered in Yangzhou, China.
The study identified several beta-lactamase genes, including bla CTX-M-15, bla CTX-M-55, and others, along with additional resistance genes such as tet(A), qnrS1, and oqxAB, contributing to multidrug resistance in ESBL/AmpC-producing E. coli isolated from stray dogs in Yangzhou, China.
Genomic Characterization of ESBL/AmpC-Producing Escherichia coli in Stray Dogs Sheltered in Yangzhou, China.
The study identified several beta-lactamase genes, including bla CTX-M-15, bla CTX-M-55, and others, along with additional resistance genes such as tet(A), qnrS1, and oqxAB, contributing to multidrug resistance in ESBL/AmpC-producing E. coli isolated from stray dogs in Yangzhou, China.
Evidence of Sharing of Carbapenem-Resistant Klebsiella pneumoniae Strains Between Intensive Care Unit Patients and the Environment.
The study identifies bla OXA-48, bla SHV, bla TEM, and bla NDM-1 as the primary carbapenem resistance genes in CR-KP strains isolated from ICU patients and the environment, highlighting the potential for environmental transmission of these strains.
A scoping review of the distribution and frequency of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in shrimp and salmon.
The study identifies various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-9, bla TEM, bla SHV, and bla CTX-M-55, in Enterobacteriaceae isolated from shrimp and salmon. These genes confer resistance to multiple β-lactam antibiotics.
Molecular characterization of extended-spectrum cephalosporin and fluoroquinolone resistance genes in Salmonella and Shigella isolated from clinical specimens in Thailand.
The study identified extended-spectrum beta-lactamase (ESBL) genes such as bla CTX-M-15, bla TEM-1, and bla CMY-2, along with quinolone resistance genes like qnrS and aac(6')-Ib-cr, in Salmonella and Shigella isolates from Thailand. Mutations in gyrA and parC genes were also found to contribute to fluoroquinolone resistance.
Knockout of Targeted Plasmid-Borne beta-lactamase Genes in an Extended-Spectrum-beta-lactamase-Producing Escherichia coli Strain: Impact on Resistance and Proteomic Profile.
The study investigated the impact of knocking out plasmid-borne beta-lactamase genes (bla CTX-M-15, bla OXA-1, and bla TEM-1) in an extended-spectrum beta-lactamase-producing E. coli strain. The knockout of bla CTX-M-15 led to significant changes in protein expression and increased susceptibility to cephalosporins, highlighting the importance of this gene in cephalosporin resistance.
Genotypic resistance determined by whole genome sequencing versus phenotypic resistance in 234 Escherichia coli isolates.
Expanded catalogue of metagenome-assembled genomes reveals resistome characteristics and athletic performance-associated microbes in horse.
The study identified a diverse array of antibiotic resistance genes (ARG) in the horse gut microbiome, highlighting the widespread use of antibiotics in horse management. The resistome characteristics were analyzed alongside the identification of microbes associated with athletic performance.
Five-Hour Detection of Intestinal Colonization with Extended-Spectrum-beta-lactamase-Producing Enterobacteriaceae Using the β-Lacta Phenotypic Test: the BLESSED Study.
The study developed the BLESSED protocol for rapid detection of intestinal colonization with ESBL-PE, demonstrating high sensitivity and specificity. It identified various CTX-M and TEM-type beta-lactamase genes in ESBL-PE strains.
Five-Hour Detection of Intestinal Colonization with Extended-Spectrum-beta-lactamase-Producing Enterobacteriaceae Using the β-Lacta Phenotypic Test: the BLESSED Study.
The study developed the BLESSED protocol for rapid detection of intestinal colonization with ESBL-PE, demonstrating high sensitivity and specificity. It identified various CTX-M and TEM-type beta-lactamase genes in ESBL-PE strains.
Longitudinal Study of Dynamic Epidemiology of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Pigs and Humans Living and/or Working on Pig Farms.
The study identified bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and bla TEM-52c as the primary ESBL genes in ESBL-producing E. coli isolates from pigs and humans on pig farms.
Antibiotic profiling of multidrug resistant pathogens in one-day-old chicks imported from Belgium to benin.
The study identified the presence of multidrug-resistant pathogens in one-day-old chicks imported from Belgium to Benin, including Escherichia coli, Enterococcus spp., and others. Resistance genes such as SulII, SulI, and blaTEM were detected, contributing to resistance against sulfonamides and beta-lactams.
Evaluation of Antimicrobial Resistance of Different Phylogroups of Escherichia coli Isolates from Feces of Breeding and Laying Hens.
The study identified blaTEM and blaCTX-M genes in three E. coli isolates, which are associated with resistance to ceftazidime. These findings highlight the presence of extended-spectrum beta-lactamase (ESBL)-producing E. coli in fecal samples from breeding and laying hens in Portugal.
First Report of IMI-2-Producing Enterobacter bugandensis and CTX-M-55-Producing Escherichia coli isolated from Healthy Volunteers in Tunisia.
The study reports the first detection of IMI-2-producing Enterobacter bugandensis and CTX-M-55-producing Escherichia coli in healthy volunteers in Tunisia, highlighting the presence of extended-spectrum beta-lactamases and carbapenemases in the fecal microbiota of healthy individuals.
Genetic Diversity and New Sequence Types of Escherichia coli Coharboring beta-lactamases and PMQR Genes Isolated from Domestic Dogs in Central Panama.
The study identified blaTEM-1, qnrS, and qnrB genes in E. coli isolates from domestic dogs in Panama, along with mutations in the AmpC gene promoter regions contributing to resistance.
Detection and homology analysis of carbapenem resistant Acinetobacter baumannii resistance gene.
The study identified several carbapenem resistance genes in Acinetobacter baumannii, including adc, oxa-51, oxa-23, qace delta 1-sull, intl1, ant (3")-i, aac (3")-i, and tem. These genes contribute to resistance against various antibiotics, particularly carbapenems and beta-lactams.
Exploring broilers and native fowls of Andaman and Nicobar Islands as a source of beta-lactamase-producing Enterobacteriaceae even with limited anthropogenic activities and docking-based identification of catalytic domains in novel beta-lactamase variants.
The study identified several beta-lactamase genes, including bla TEM-1, bla SHV-11, bla SHV-27, bla SHV-228, bla CTX-M-15, and bla AmpC, in Enterobacteriaceae isolates from broilers and native fowls in the Andaman and Nicobar Islands. These genes were found to confer resistance to various β-lactam antibiotics.
Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009-2018.
The study identifies multiple AMR genes associated with multidrug-resistant Salmonella enterica serotype 4,[5],12:i:-, including genes conferring resistance to ampicillin, streptomycin, sulfamethoxazole, tetracycline, ciprofloxacin, ceftriaxone, azithromycin, and colistin. These genes are prevalent in a multidrug-resistant clade linked to pork consumption.
A Cross-Validated Feature Selection (CVFS) approach for extracting the most parsimonious feature sets and discovering potential antimicrobial resistance (AMR) biomarkers.
The study presents a Cross-Validated Feature Selection (CVFS) approach for identifying the most parsimonious gene sets for predicting antimicrobial resistance (AMR) from bacterial pan-genomes. The CVFS approach was able to extract both known and novel AMR genes, demonstrating its effectiveness in selecting relevant features for AMR prediction.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Phylogenetic analysis and antibiotic resistance of Escherichia coli isolated from wild and domestic animals at an agricultural land interface area of Salaphra wildlife sanctuary, Thailand.
The study identified several AMR genes in E. coli isolates from wild and domestic animals in Thailand, including blaTEM, blaSHV, blaCMY-2, aac(3)-IV, aadA, tetA, tetB, qnrA, sul3, dfrA1, dfrA5, and dfrA7, which conferred resistance to various antibiotics such as ampicillin, gentamicin, tetracycline, ciprofloxacin, and trimethoprim-sulfamethoxazole.
Isolation of multidrug-resistant Escherichia coli and Salmonella spp. from sulfonamide-treated diarrheic calves.
The study identified multidrug-resistant (MDR) Escherichia coli and Salmonella spp. from sulfonamide-treated diarrheic calves, with the presence of tetA and blaTEM genes contributing to resistance against tetracycline and beta-lactam antibiotics, respectively.
An ST131 clade and a phylogroup A clade bearing an O101-like O-antigen cluster predominate among bloodstream Escherichia coli isolates from South-West Nigeria hospitals.
The study identified several AMR genes and mutations in bloodstream E. coli isolates from South-West Nigeria, including bla CTX-M-15, dfrA, dfrB, and various quinolone resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
An ST131 clade and a phylogroup A clade bearing an O101-like O-antigen cluster predominate among bloodstream Escherichia coli isolates from South-West Nigeria hospitals.
The study identified several AMR genes and mutations in bloodstream E. coli isolates from South-West Nigeria, including bla CTX-M-15, dfrA, dfrB, and various quinolone resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
An ST131 clade and a phylogroup A clade bearing an O101-like O-antigen cluster predominate among bloodstream Escherichia coli isolates from South-West Nigeria hospitals.
The study identified several AMR genes and mutations in bloodstream E. coli isolates from South-West Nigeria, including bla CTX-M-15, dfrA, dfrB, and various quinolone resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
An ST131 clade and a phylogroup A clade bearing an O101-like O-antigen cluster predominate among bloodstream Escherichia coli isolates from South-West Nigeria hospitals.
The study identified several AMR genes and mutations in bloodstream E. coli isolates from South-West Nigeria, including bla CTX-M-15, dfrA, dfrB, and various quinolone resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Antibacterial efficacy of indigenous Pakistani honey against extensively drug-resistant clinical isolates of Salmonella enterica serovar Typhi: an alternative option to combat antimicrobial resistance.
The study identifies multiple AMR genes, including blaCTX-M-15, blaTEM-1, qnrS, qnrA, qnrB, Sul1, and pltB, in XDR S. Typhi isolates. Indigenous Pakistani honeys, particularly beri and neem honey, show potent antibacterial activity against these isolates.
Whole genome sequence analysis of the first reported isolate of Salmonella Agona carrying blaCTX-M-55 gene in Brazil.
The study identifies the first report of Salmonella Agona isolate carrying the blaCTX-M-55 gene in Brazil, which confers resistance to various cephalosporins and other beta-lactam antibiotics. Additionally, the blaTEM-1B gene was also found in the same isolate, contributing to resistance against ampicillin and amoxicillin/clavulanic acid.
beta-lactamase Producing Escherichia coli Encoding bla(CTX-M) and bla(CMY) Genes in Chicken Carcasses from Egypt.
The study identified bla(CTX-M) and bla(CMY) genes in multidrug-resistant E. coli isolates from chicken carcasses in Egypt, highlighting the presence of extended-spectrum beta-lactamases and AmpC beta-lactamases, which confer resistance to several β-lactam antibiotics.
Beta-Lactam Antibiotic Resistance Genes in the Microbiome of the Public Transport System of Quito, Ecuador.
The study identified beta-lactam resistance genes, including blaTEM, mecA, blaCTX-M-1, and blaOXA-181, in the microbiome of Quito's Public Transport system. It reports the first detection of blaOXA-181 in environmental samples in Ecuador and identifies subvariants of these genes.
Trends of β-Lactamase Occurrence Among Escherichia coli and Klebsiella pneumoniae in United States Hospitals During a 5-Year Period and Activity of Antimicrobial Agents Against Isolates Stratified by β-Lactamase Type.
The study identified various β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-27, bla SHV-12, bla SHV-7, bla SHV-27, bla TEM-1, bla TEM-12, bla CMY-2, bla DHA-1, bla FOX-5, bla OXA-1, bla OXA-1-like, bla KPC-2, bla KPC-3, bla NDM-1, bla NDM-5, bla OXA-181, bla OXA-48, and bla OXA-232, which confer resistance to β-lactam antibiotics. The study also found that CTX-M-15 was the most prevalent β-lactamase gene, and there was a notable increase in ESBL-producing isolates among K. pneumoniae.
Trends of β-Lactamase Occurrence Among Escherichia coli and Klebsiella pneumoniae in United States Hospitals During a 5-Year Period and Activity of Antimicrobial Agents Against Isolates Stratified by β-Lactamase Type.
The study identified various β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-27, bla SHV-12, bla SHV-7, bla SHV-27, bla TEM-1, bla TEM-12, bla CMY-2, bla DHA-1, bla FOX-5, bla OXA-1, bla OXA-1-like, bla KPC-2, bla KPC-3, bla NDM-1, bla NDM-5, bla OXA-181, bla OXA-48, and bla OXA-232, which confer resistance to β-lactam antibiotics. The study also found that CTX-M-15 was the most prevalent β-lactamase gene, and there was a notable increase in ESBL-producing isolates among K. pneumoniae.
In silico analyses of diversity and dissemination of antimicrobial resistance genes and mobile genetics elements, for plasmids of enteric pathogens.
The study identifies a diverse array of antimicrobial resistance (AMR) genes across various plasmid replicon types in enteric pathogens, highlighting the prevalence of resistance genes in plasmids such as IncHI2, IncN, IncA/C, IncP, IncHI1, and IncFIA. Key AMR genes include aac(3)-IId, aac(3)-IIg, aac(6')-Ib3, aadA1, aadA5, aph(3'')-Ib, bla CMY-2, bla CTX-M-27, bla NDM-1, mcr-9.1, and others, which confer resistance to antibiotics such as gentamicin, cephalosporins, carbapenems, colistin, and tetracycline.
Antimicrobial resistance patterns and characterisation of emerging beta-lactamase-producing Escherichia coli in camels sampled from Northern Kenya.
The study identified bla TEM-1, bla TEM-116, bla TEM-104, bla CTX-M-15, and bla CTX-M-27 genes in E. coli isolates from camels in Northern Kenya, highlighting the presence of both ESBL and non-ESBL beta-lactamase producers.
Antimicrobial resistance patterns and characterisation of emerging beta-lactamase-producing Escherichia coli in camels sampled from Northern Kenya.
The study identified bla TEM-1, bla TEM-116, bla TEM-104, bla CTX-M-15, and bla CTX-M-27 genes in E. coli isolates from camels in Northern Kenya, highlighting the presence of both ESBL and non-ESBL beta-lactamase producers.
Antimicrobial resistance patterns and characterisation of emerging beta-lactamase-producing Escherichia coli in camels sampled from Northern Kenya.
The study identified bla TEM-1, bla TEM-116, bla TEM-104, bla CTX-M-15, and bla CTX-M-27 genes in E. coli isolates from camels in Northern Kenya, highlighting the presence of both ESBL and non-ESBL beta-lactamase producers.
Silver nanoparticles enhance the efficacy of aminoglycosides against antibiotic-resistant bacteria.
The study identifies several AMR genes, including mcr-1, mcr-3, mcr-4, aadA5, catA1, bla CMY-2, bla CTX-M-55, dfrA17, fosA, mph(A), rmtB, strA, strB, sul1, sul2, bla TEM-1B, and bla CMY-48, which confer resistance to various antibiotics in different bacterial strains.
Epidemiology and Genetic Characteristics of Carbapenem-Resistant Escherichia coli in Chinese Intensive Care Unit Analyzed by Whole-Genome Sequencing: a Prospective Observational Study.
The study identified bla KPC-2 and bla NDM-5 as the main carbapenem resistance genes in carbapenem-resistant Escherichia coli (CREC) isolates. Additionally, various other resistance genes were detected, including extended-spectrum beta-lactamases (CTX-M-14, CTX-M-15, CTX-M-27, CTX-M-3, OXA-1, OXA-10, TEM-1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-Iva, aac(6′)-Ib-AKT, aac(6′)-Ib-D181Y, aadA1, aadA2, aadA5, aph(3″)-Ib, aph(3′)-Ia, aph(4)-Ia, aph(6)-Id), quinolone resistance genes (qnrS1, qnrS2), tetracycline resistance genes (oqxA10, oqxB17), fosfomycin resistance gene (fosA3), and chloramphenicol resistance genes (cmlA1, cmlA5).
Prevalence of extended spectrum beta lactamase and molecular detection of blaTEM, blaSHV and blaCTX-M genotypes among Gram negative bacilli isolates from pediatric patient population in Gaza strip.
The study identified blaTEM, blaSHV, and blaCTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) resistance in Gram-negative bacilli from pediatric patients in Gaza strip. These genes were prevalent among various bacterial species, with blaCTX-M being the most dominant.
Molecular characterizations of antibiotic resistance, biofilm formation, and virulence determinants of Pseudomonas aeruginosa isolated from burn wound infection.
The study identified bla TEM, bla VIM, and bla CTX-M as the most common beta-lactamase genes in Pseudomonas aeruginosa isolates from burn wounds, contributing to resistance against multiple antibiotics.
oprL Gene Sequencing, Resistance Patterns, Virulence Genes, Quorum Sensing and Antibiotic Resistance Genes of XDR Pseudomonas aeruginosa Isolated from Broiler Chickens.
The study identified XDR P. aeruginosa strains from broiler chickens in Egypt, which harbor multiple antibiotic resistance genes including bla TEM, bla CTX-M, bla OXA-1, aad A1, tet A, and sul 1. These strains showed resistance to multiple antimicrobial classes.
Relationship Between Drug Resistance Characteristics and Biofilm Formation in Klebsiella Pneumoniae Strains.
The study identified ESBL genes blaTEM, blaSHV, and blaCTX-M in Klebsiella pneumoniae strains, which confer resistance to various beta-lactam antibiotics. Additionally, virulence genes such as rmpA, fimH, mrkD, entB, ybtS, allS, and kfu were found to be associated with hypervirulent K. pneumoniae strains.
High Prevalence of Group III-Like Mutations Among BLPACR and First Report of Haemophilus influenzae ST95 Isolated from Blood in China.
Characterization of Extensively Drug-Resistant Salmonella enterica Serovar Kentucky Sequence Type 198 Isolates from Chicken Meat Products in Xuancheng, China.
Extensively drug-resistant Salmonella enterica serovar Kentucky ST198 isolates from chicken meat products in Xuancheng, China, were characterized. These isolates carried multiple resistance genes, including bla CTX-M-55, bla TEM-1B, aac(3)-IId, aadA17, rmtB, tet(A), floR, lnu(F), arr-2, qnrS1, sul1, mph(A), and fosA3, and mutations in gyrA (S83F, D87N) and parC (S80I), leading to resistance against several antimicrobial agents.
House Flies (Musca domestica) from Swine and Poultry Farms Carrying Antimicrobial Resistant Enterobacteriaceae and Salmonella.
The study identified the blaTEM-1 gene in an extended spectrum beta-lactamase producer strain of Enterobacteriaceae, indicating resistance to ampicillin. High levels of resistance to ampicillin and tetracycline were detected in Enterobacteriaceae isolates.
Emergence of colistin resistance and characterization of antimicrobial resistance and virulence factors of Aeromonas hydrophila, Salmonella spp., and Vibrio cholerae isolated from hybrid red tilapia cage culture.
The study identified several AMR genes in Aeromonas hydrophila, Salmonella spp., and Vibrio cholerae isolated from hybrid red tilapia. Notably, mcr-3 was found in A. hydrophila, and qnrS, tetA, blaTEM, and floR were prevalent in Salmonella spp. No colistin resistance genes were detected in V. cholerae.
Evaluation of the antibacterial activity of Weissella confusa K3 cell-free supernatant against extended-spectrum βeta lactamase (ESBL) producing uropathogenic Escherichia coli U60.
Weissella confusa K3 cell-free supernatant showed antibacterial activity against ESBL-producing E. coli U60, reducing the expression of the bla TEM gene.
Development of Nanobodies as Theranostic Agents against CMY-2-Like Class C β-Lactamases.
The study identifies three nanobodies (cAb CMY-2 (250), cAb CMY-2 (254), and cAb CMY-2 (272)) that specifically bind to CMY-2 β-lactamase, with cAb CMY-2 (254) showing the highest stability and affinity. These nanobodies act as noncompetitive inhibitors of CMY-2 activity and are used to develop a highly specific sandwich ELISA for detecting CMY-2-producing bacteria.
Multidrug-resistant extended spectrum β-lactamase (ESBL)-producing Escherichia coli from farm produce and agricultural environments in Edo State, Nigeria.
The study identified various AMR genes in ESBL-producing E. coli isolates from agricultural farms and open markets in Edo State, Nigeria, including blaTEM, blaCTX-M-1, blaCTX-M-15, tetM, tetA, tetB, sul1, sul2, sul3, ant(4')-Ia, aacC(3)-1, qnrA, qnrB, qnrC, qnrS, cat::pC194, cat::pC221, intI1, and intI2. These genes conferred resistance to multiple antibiotics, indicating the presence of multidrug-resistant E. coli in the studied environments.
Bacterial profile, antimicrobial resistance, and molecular detection of ESBL and quinolone resistance gene of uropathogens causing urinary tract infection in the southeastern part of Bangladesh.
The study identified ESBL genes bla CTX-M-15 and bla TEM, as well as quinolone resistance genes qnr S, aac-6'-Ib-cr, and gyr A in uropathogens causing urinary tract infections in Bangladesh.
A multicentre study reveals dysbiosis in the microbial co-infection and antimicrobial resistance gene profile in the nasopharynx of COVID-19 patients.
The study identified a variety of antimicrobial resistance genes in the nasopharynx of COVID-19 patients, including beta-lactamases, macrolide-lincosamide-streptogramin resistance genes, tetracycline resistance genes, and others. These genes were found to be prevalent in both symptomatic and asymptomatic patients, highlighting the importance of monitoring antimicrobial resistance in the context of the pandemic.
Extended-Spectrum β-Lactamase Genes Traverse the Escherichia coli Populations of Intensive Care Unit Patients, Staff, and Environment.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-55, bla CTX-M-14, bla CTX-M-15, bla CTX-M-65, bla CTX-M-27, bla CTX-M-3, bla CTX-M-24, bla CMY-146, bla CMY-2, bla DHA-1, and bla TEM, which are responsible for conferring resistance to multiple beta-lactam antibiotics in Escherichia coli isolates from an ICU setting.
Detection of antimicrobial resistance genes in Lactobacillus spp. from poultry probiotic products and their horizontal transfer among Escherichia coli.
The study identified antimicrobial resistance genes (ARGs) in Lactobacillus spp. from poultry probiotic products, including bla TEM, bla CTX-M-1, bla CTX-M-2, qnr S, tet A, and tet B. These genes were horizontally transferred to E. coli during co-culture, highlighting the potential risk of AMR spread in poultry populations.
High prevalence of extensively drug resistant and extended spectrum beta lactamases (ESBLs) producing uropathogenic Escherichia coli isolated from Faisalabad, Pakistan.
The study identified several ESBL genes including TEM-1, CTX-M1, CTX-M15, OXA-1, KPC, VIM, and GES in uropathogenic E. coli isolates from Faisalabad, Pakistan. These genes were associated with resistance to various beta-lactam antibiotics, highlighting the high prevalence of multidrug-resistant strains.
Smartphone-operated affordable PCR thermal cycler for the detection of antimicrobial resistant bacterial genes.
The study developed a low-cost, portable PCR thermal cycler capable of detecting antimicrobial resistance genes such as bla-TEM and bla-CTXM in E. coli isolates from human urine samples. The system demonstrated accurate detection of these genes with 100% accuracy.
Occurrence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in raw milk from cows with subclinical mastitis in northeast Brazil.
The study identified ESBL-producing Enterobacteriaceae in raw milk from cows with subclinical mastitis in northeast Brazil, highlighting the presence of blaSHV and blaTEM genes.
Phenotypic and genotypic survey of antibiotic resistance in Salmonella enterica isolates from dairy farms in Uruguay.
The study identified 21 AMR genes in Salmonella enterica isolates from dairy farms in Uruguay, including genes conferring resistance to aminoglycosides, tetracyclines, sulfonamides, beta-lactams, and quinolones. Two chromosomal mutations, parC_T57S and acrB_R717Q, were also detected, contributing to resistance against quinolones and azithromycin, respectively.
Whole-Genome Analysis of Antimicrobial-Resistant Salmonella enterica Isolated from Duck Carcasses in Hanoi, Vietnam.
The study identified 43 antibiotic resistance genes in Salmonella enterica isolates from duck carcasses in Hanoi, Vietnam, including genes conferring resistance to multiple antibiotic classes such as aminoglycosides, beta-lactams, quinolones, and tetracyclines.
Antimicrobial Peptides Designed against the Ω-Loop of Class A beta-lactamases to Potentiate the Efficacy of β-Lactam Antibiotics.
Six histidine-based pentapeptides (TSHLH, ETHIH, ESRLH, ESHIH, ESRIH, and TYHLH) were found to inhibit class A beta-lactamases (TEM-1 and SHV-14), enhancing the efficacy of β-lactam antibiotics against Gram-negative and acid-fast bacteria.
Genomic Diversity, Antimicrobial Susceptibility, and Biofilm Formation of Clinical Acinetobacter baumannii Isolates from Horses.
The study identified multiple AMR genes in equine Acinetobacter baumannii isolates, including beta-lactamases (bla OXA-51-like, bla ADC-25, bla TEM-1D), sulfonamide resistance genes (sul1, sul2), chloramphenicol resistance genes (catA1, ABUW 0982), tetracycline resistance genes (tet(A), tet(B), tet(39)), and aminoglycoside modifying enzymes (aph(3′)-Ia, aph(3`)-Ic, aph(6)-Id, aac(3)-Ia). Additionally, eight novel OXA-51-like variants (OXA-970 to OXA-977) were characterized.
Investigating Catheter-Related Infections in Southern Benin Hospitals: Identification, Susceptibility, and Resistance Genes of Involved Bacterial Strains.
The study identified several beta-lactam resistance genes, including bla TEM, bla SHV, bla CTX-M-1, bla CTX-M-15, and bla NDM, in bacterial strains causing catheter-related infections in southern Benin hospitals.
Antimicrobial Resistance in Vaginal Bacteria in Inseminated Mares.
The study identified several AMR genes in E. coli, S. equisimilis, and S. simulans, including sul1, sul2, dfrA1, dfrA14, tet(A), mdf(A), blaEC-5, blaTEM-1, blaTEM-1B, blaEC, catB3, aadA5, aph(6)-ld, lsaC, and blaZ, which conferred resistance to various antibiotics.
Antimicrobial Resistance in Vaginal Bacteria in Inseminated Mares.
The study identified several AMR genes in E. coli, S. equisimilis, and S. simulans, including sul1, sul2, dfrA1, dfrA14, tet(A), mdf(A), blaEC-5, blaTEM-1, blaTEM-1B, blaEC, catB3, aadA5, aph(6)-ld, lsaC, and blaZ, which conferred resistance to various antibiotics.
Prevalence and Characterization of Salmonella Isolated from Chickens in Anhui, China.
The study identified several AMR genes in Salmonella isolates from chickens in Anhui, China, including blaTEM, blaCMY-2, aadA, strA, aph(3')-IIa, aac(6')-Ib-cr, qnrB, qnrS, sul1, sul2, tetA, tetB, cat1, and floR. These genes were associated with resistance to various antibiotics such as ampicillin, cephalosporins, streptomycin, gentamicin, amikacin, fluoroquinolones, sulfamethoxazole, tetracycline, chloramphenicol, and florfenicol.
High frequency of NDM-1 and OXA-48 carbapenemase genes among Klebsiella pneumoniae isolates in central Iran.
The study identified high frequencies of bla TEM, bla CTX-M1, bla SHV, bla CTX-M15, bla CIT, bla CMY-2, bla NDM, bla OXA-48, qnrB, qnrS, qnrA, tetA, tetB, sul1, sul2, int1, and int2 genes in Klebsiella pneumoniae isolates from central Iran, highlighting the prevalence of multidrug-resistant and carbapenem-resistant strains.
Prevalence and resistance to antibacterial agents in Salmonella enterica strains isolated from poultry products in Northern Kazakhstan.
The study identified several AMR genes in Salmonella enterica strains from poultry products in Northern Kazakhstan, including tetA, tetB, blaTEM, aadA, sul3, catII, and cmlA, which confer resistance to various antibiotics such as tetracycline, beta-lactams, aminoglycosides, sulfonamides, and chloramphenicol.
The Characteristics of Extended-Spectrum beta-lactamases (ESBLs)-Producing Escherichia coli in Bloodstream Infection.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M, bla TEM, bla SHV, bla OXA-1, and the colistin resistance gene mcr-1, in ESBL-producing Escherichia coli strains causing bloodstream infections.
Antimicrobial resistance and genomic characterization of Salmonella enterica isolates from chicken meat.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from chicken meat, including aminoglycoside, beta-lactam, quinolone, tetracycline, sulfonamide, and phenicol resistance genes. These genes were detected using whole genome sequencing and correlated with phenotypic resistance profiles.
Antimicrobial resistance and genomic characterization of Salmonella enterica isolates from chicken meat.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from chicken meat, including aminoglycoside, beta-lactam, quinolone, tetracycline, sulfonamide, and phenicol resistance genes. These genes were detected using whole genome sequencing and correlated with phenotypic resistance profiles.
Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications.
The study characterizes mutations in TEM-1 and TEM-50 beta-lactamases that affect susceptibility to amoxicillin, highlighting the impact of specific amino acid changes on drug resistance.
Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications.
The study characterizes mutations in TEM-1 and TEM-50 beta-lactamases that affect susceptibility to amoxicillin, highlighting the impact of specific amino acid changes on drug resistance.
Genome profiling of uropathogenic E. coli from strictly defined community-acquired UTI in paediatric patients: a multicentric study.
The study identified multiple AMR genes in E. coli isolates from pediatric UTI cases, including bla CTX-M-15, bla NDM-5, bla OXA-1, and others, highlighting the presence of high-risk clones like ST131 and ST167.
Identification of diverse antibiotic resistant bacteria in agricultural soil with H(2)(18)O stable isotope probing combined with high-throughput sequencing.
The study identified several antimicrobial resistance genes (ARGs) in agricultural soil using H2 18O stable isotope probing combined with high-throughput sequencing. These included aph(3')-IIc, oqxB, blaTEM-181, blaL1, and dfrB3, which conferred resistance to various antibiotics such as aminoglycosides, chloramphenicol, quinolones, trimethoprim, and beta-lactams.
Serotype distribution, trend of multidrug resistance and prevalence of beta-lactamase resistance genes in human Salmonella isolates from clinical specimens in Guizhou, China.
The study identified the prevalence of beta-lactamase resistance genes, including bla TEM, bla CTX-M, bla OXA-1, and bla CMY, in Salmonella isolates from Guizhou, China. These genes conferred resistance to various β-lactam antibiotics.
High prevalence of β-lactam and fluoroquinolone resistance in various phylotypes of Escherichia coli isolates from urinary tract infections in Jiroft city, Iran.
The study identified a high prevalence of β-lactam resistance genes (bla TEM, bla CTX-M, bla SHV, and bla CMY) and fluoroquinolone resistance in E. coli isolates from urinary tract infections in Jiroft, Iran. The most common resistance patterns were observed in phylotypes B2 and D.
Antibiotic resistance in Helicobacter pylori: From potential biomolecular mechanisms to clinical practice.
The paper discusses the mechanisms of antibiotic resistance in Helicobacter pylori, focusing on genes and mutations associated with resistance to amoxicillin, clarithromycin, furazolidone, levofloxacin, and metronidazole. Key findings include the identification of specific mutations in 23S rRNA, gyrA, gyrB, PBP1A, porD, oorD, RdxA, and other genes that contribute to resistance against these antibiotics.
Genetic characterization of ESBL-producing and ciprofloxacin-resistant Escherichia coli from Belgian broilers and pigs.
The study identified various ESBL genes such as bla CTX-M-1, bla CTX-M-32, bla CTX-M-15, bla SHV-12, bla TEM-52C, and bla TEM-52B, as well as PMQR genes like qnrS1 and qnrB19, in ESBL-producing and ciprofloxacin-resistant E. coli from Belgian broilers and pigs. Additionally, colistin resistance genes mcr-1.1, mcr-2.1, and mcr-9 were detected. Mutations in gyrA (S83L, D87N) and parC (S80I) were strongly associated with fluoroquinolone resistance.
Genetic characterization of ESBL-producing and ciprofloxacin-resistant Escherichia coli from Belgian broilers and pigs.
The study identified various ESBL genes such as bla CTX-M-1, bla CTX-M-32, bla CTX-M-15, bla SHV-12, bla TEM-52C, and bla TEM-52B, as well as PMQR genes like qnrS1 and qnrB19, in ESBL-producing and ciprofloxacin-resistant E. coli from Belgian broilers and pigs. Additionally, colistin resistance genes mcr-1.1, mcr-2.1, and mcr-9 were detected. Mutations in gyrA (S83L, D87N) and parC (S80I) were strongly associated with fluoroquinolone resistance.
Genomic and functional characterization of carbapenem-resistant Klebsiella pneumoniae from hospital wastewater.
The study identified the bla KPC-2 gene as a major contributor to carbapenem resistance in Klebsiella pneumoniae isolates from hospital wastewater, demonstrating its successful in vitro transfer through conjugation.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
Phenotypic and Genotypic Characteristics of Antimicrobial Resistance in Citrobacter freundii Isolated from Domestic Ducks (Anas platyrhynchos domesticus) in Bangladesh.
The study identified multiple AMR genes in Citrobacter freundii isolates from domestic ducks in Bangladesh, including beta-lactamases (bla TEM-1, bla CMY-2, bla CMY-9, bla CTX-M-14), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tetA, tetB), fluoroquinolone resistance genes (qnrA, qnrB, qnrS), and an aminoglycoside resistance gene (aacC4).
Antimicrobial resistance, Extended-Spectrum β-Lactamase production and virulence genes in Salmonella enterica and Escherichia coli isolates from estuarine environment.
The study identified several AMR genes in Salmonella and E. coli isolates from estuarine environments, including bla TEM, cmlA, sul3, tetA, dfrA12, and bla CTX-M-55, highlighting the presence of multidrug-resistant and ESBL-producing bacteria in these environments.
Antimicrobial resistance, Extended-Spectrum β-Lactamase production and virulence genes in Salmonella enterica and Escherichia coli isolates from estuarine environment.
The study identified several AMR genes in Salmonella and E. coli isolates from estuarine environments, including bla TEM, cmlA, sul3, tetA, dfrA12, and bla CTX-M-55, highlighting the presence of multidrug-resistant and ESBL-producing bacteria in these environments.
Incidence and antibiotic susceptibility profile of uropathogenic Escherichia coli positive for extended spectrum β-lactamase among HIV/AIDS patients in Awka metropolis, Nigeria.
The study reports the presence of ESBL genes, specifically bla TEM (5.0%) and bla CTX-M-15 (6.9%), in uropathogenic E. coli isolates from HIV/AIDS patients in Awka, Nigeria, indicating a significant prevalence of multidrug-resistant strains.
Investigating Possible Interspecies Communication of Plasmids Associated with Transfer of Third-Generation Cephalosporin, Quinolone, and Colistin Resistance Between Simultaneously Isolated Escherichia Coli and Klebsiella Pneumoniae.
The study identified multiple AMR genes in E. coli and K. pneumoniae isolates, including bla CTX-M-14, qnrS1, mcr-1.1, and others, highlighting the role of plasmids in the transfer of resistance genes between species.
Virotyping and genetic antimicrobial susceptibility testing of porcine ETEC/STEC strains and associated plasmid types.
The study identified several AMR genes and mutations in porcine ETEC/STEC strains, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-106), polymyxin resistance genes (mcr-1.1, mcr-2.1, mcr-5.1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-IV, aac(3)-IVa, aph(3')-Ia, aadA1, aadA10, aadA12), florfenicol resistance gene (floR), tetracycline resistance genes (tet(A), tet(B)), quinolone resistance gene (qnrS1), and trimethoprim-sulfamethoxazole resistance genes (dfrA1, dfrA5, dfrA12, dfrA14, dfrA36).
Virotyping and genetic antimicrobial susceptibility testing of porcine ETEC/STEC strains and associated plasmid types.
The study identified several AMR genes and mutations in porcine ETEC/STEC strains, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-106), polymyxin resistance genes (mcr-1.1, mcr-2.1, mcr-5.1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-IV, aac(3)-IVa, aph(3')-Ia, aadA1, aadA10, aadA12), florfenicol resistance gene (floR), tetracycline resistance genes (tet(A), tet(B)), quinolone resistance gene (qnrS1), and trimethoprim-sulfamethoxazole resistance genes (dfrA1, dfrA5, dfrA12, dfrA14, dfrA36).
Virotyping and genetic antimicrobial susceptibility testing of porcine ETEC/STEC strains and associated plasmid types.
The study identified several AMR genes and mutations in porcine ETEC/STEC strains, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-106), polymyxin resistance genes (mcr-1.1, mcr-2.1, mcr-5.1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-IV, aac(3)-IVa, aph(3')-Ia, aadA1, aadA10, aadA12), florfenicol resistance gene (floR), tetracycline resistance genes (tet(A), tet(B)), quinolone resistance gene (qnrS1), and trimethoprim-sulfamethoxazole resistance genes (dfrA1, dfrA5, dfrA12, dfrA14, dfrA36).
Virotyping and genetic antimicrobial susceptibility testing of porcine ETEC/STEC strains and associated plasmid types.
The study identified several AMR genes and mutations in porcine ETEC/STEC strains, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-106), polymyxin resistance genes (mcr-1.1, mcr-2.1, mcr-5.1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-IV, aac(3)-IVa, aph(3')-Ia, aadA1, aadA10, aadA12), florfenicol resistance gene (floR), tetracycline resistance genes (tet(A), tet(B)), quinolone resistance gene (qnrS1), and trimethoprim-sulfamethoxazole resistance genes (dfrA1, dfrA5, dfrA12, dfrA14, dfrA36).
Virotyping and genetic antimicrobial susceptibility testing of porcine ETEC/STEC strains and associated plasmid types.
The study identified several AMR genes and mutations in porcine ETEC/STEC strains, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-106), polymyxin resistance genes (mcr-1.1, mcr-2.1, mcr-5.1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-IV, aac(3)-IVa, aph(3')-Ia, aadA1, aadA10, aadA12), florfenicol resistance gene (floR), tetracycline resistance genes (tet(A), tet(B)), quinolone resistance gene (qnrS1), and trimethoprim-sulfamethoxazole resistance genes (dfrA1, dfrA5, dfrA12, dfrA14, dfrA36).
Characterization of Serotypes and Molecular Drug Resistance Patterns of Haemophilus influenzae in Kunming Children.
The study identified beta-lactamase genes TEM-1 and ROB-1, and mutations in the ftsI gene (PBP3-BLN and PBP3-s) as major contributors to ampicillin resistance in Haemophilus influenzae isolates from Kunming children.
Molecular detection of plasmid mediated bla(TEM), bla(CTX-M,)and bla(SHV) genes in Extended Spectrum β-Lactamase (ESBL) Escherichia coli from clinical samples.
The study identified bla(TEM) and bla(CTX-M) genes as the most prevalent ESBL genes in E. coli isolates, with bla(TEM) being the dominant genotype. The majority of ESBL-producing E. coli isolates showed resistance to cephalosporins and monobactams.
Plasmid-mediated colistin resistance among human clinical Enterobacterales isolates: national surveillance in the Czech Republic.
The study identified mcr-1, mcr-4, and mcr-9 genes in colistin-resistant Enterobacterales isolates from the Czech Republic, highlighting their association with plasmid-mediated resistance and multidrug resistance features.
Plasmid-mediated colistin resistance among human clinical Enterobacterales isolates: national surveillance in the Czech Republic.
The study identified mcr-1, mcr-4, and mcr-9 genes in colistin-resistant Enterobacterales isolates from the Czech Republic, highlighting their association with plasmid-mediated resistance and multidrug resistance features.
Plasmid-mediated colistin resistance among human clinical Enterobacterales isolates: national surveillance in the Czech Republic.
The study identified mcr-1, mcr-4, and mcr-9 genes in colistin-resistant Enterobacterales isolates from the Czech Republic, highlighting their association with plasmid-mediated resistance and multidrug resistance features.
Molecular Characterization of the Convergent Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae Strain K1-ST23, Collected in Chile during the COVID-19 Pandemic.
The study identified carbapenem-resistant hypervirulent Klebsiella pneumoniae strain K-2157, which harbors multiple AMR genes including blaSHV-190, blaTEM-1, blaOXA-9, blaKPC-2, fosA, oqxA, and oqxB, along with virulence-associated plasmids and an integrative and conjugative element (ICE).
Phenotypic and genetic screening of Klebsiella pneumoniae isolates from human UTI patients for beta-lactamases and their genetic diversity analysis by ERIC and REP PCRs.
The study identified bla TEM, bla OXA, bla CTX-M-1, FOX, CIT, and NDM-1 genes in Klebsiella pneumoniae isolates from human UTI patients, highlighting the prevalence of beta-lactamase-producing strains and their genetic diversity.
Development and evaluation of a centrifugal disk system for the rapid detection of multiple pathogens and their antibiotic resistance genes in urinary tract infection.
The study developed a centrifugal disk system (LCD) for the rapid detection of multiple pathogens and their antibiotic resistance genes (ARGs) in urinary tract infections (UTIs). The LCD platform demonstrated high specificity and sensitivity for detecting pathogens and ARGs, including beta-lactamases (SHV, TEM, CTX-M-1 group, CTX-M-9 group), carbapenemases (KPC, NDM, IMP, OXA-23, OXA-24, OXA-48), ampC beta-lactamases (DHA, CMY), glycopeptide resistance (VanA), and methicillin resistance (mecA).
Molecular Characterization of Extensively Drug Resistant Salmonella Enterica Serovar Typhi Clinical Isolates from Lahore, Pakistan.
The study identified multiple AMR genes in XDR Salmonella Typhi isolates from Lahore, Pakistan, including blaTEM-1, catA1, sul1, dhfR7, qnrS, gyrA, gyrB, parC, parE, blaCTX-M-U, blaCTX-M-1, and blaCTX-M-15, which confer resistance to various antibiotics such as ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, fluoroquinolones, and third-generation cephalosporins.
Molecular detection and antimicrobial resistance profiles of Extended-Spectrum Beta-Lactamase (ESBL) producing Escherichia coli in broiler chicken farms in Malaysia.
The study identified bla CTX-M, bla TEM, and mcr-1 genes as the primary resistance mechanisms in ESBL-producing E. coli isolates from broiler chicken farms in Malaysia.
Epidemiological investigation and drug resistance characteristics of Riemerella anatipestifer strains from large-scale duck farms in Shandong Province, China from March 2020 to March 2022.
The study identified multiple drug resistance genes in R. anatipestifer strains, including high prevalence of tetracycline resistance gene tet X (95.9%), macrolide resistance gene ermF (77%), and others. The strains exhibited multidrug resistance, with the highest resistance to gentamicin (77%) and enrofloxacin (73%).
Molecular epidemiology of enterically colonizing Escherichia coli with resistance against third-generation cephalosporins isolated from stool samples of European soldiers with concomitant diarrhea on deployment in Western African Mali.
The study identified bla CTX-M-15 and bla TEM-1b as the primary genes responsible for third-generation cephalosporin resistance in E. coli isolates from European soldiers in Mali. Additionally, several quinolone resistance genes including qnrS1, gyrA S83L, gyrA D87N, parE S458T, parE S458A, and parC S80I were found. Trimethoprim-sulfamethoxazole resistance was mediated by sul1, sul2, dfrA1, dfrA5, dfrA14, and dfrA17. Gentamicin resistance was associated with aph6-Id, aph3-Ib, aac3-IId, aadA5, and aac6-Ib-cr5. Tetracycline resistance was conferred by tetA, tetB, and tetD.
Antimicrobial resistance and virulence genes of invasive Salmonella enterica from children with bacteremia in north-central Nigeria.
The study identified multiple antimicrobial resistance genes in invasive Salmonella enterica isolates from children with bacteremia in north-central Nigeria, including bla TEM, flo R, qnr A, tet A, tet B, and tet G. These genes conferred resistance to various antibiotics such as ampicillin, trimethoprim-sulfamethoxazole, chloramphenicol, tetracycline, and ciprofloxacin.
Co-Harboring of Beta-Lactamases and mcr-1 Genes in Escherichia coli and Klebsiella pneumoniae from Healthy Carriers and Backyard Animals in Rural Communities in Ecuador.
The study identified the co-harborance of beta-lactamase genes (bla TEM, bla SHV, bla CTX-M-9, bla CTX-M-1, bla OXA-48, bla NDM) and the mcr-1 gene in Escherichia coli and Klebsiella pneumoniae isolates from healthy humans and backyard animals in rural Ecuador. These findings highlight the potential threat to the efficacy of last-resort antibiotics.
Cross-Sectional Study for Detection and Risk Factor Analysis of ESBL-Producing Avian Pathogenic Escherichia coli Associated with Backyard Chickens in Pakistan.
The study identified bla CTX-M and bla TEM genes as the primary ESBL genes in E. coli isolates from backyard chickens in Pakistan, with bla CTX-M being the most prevalent.
Concordance between Genotypic and Phenotypic Drug-Resistant Profiles of Shigella Isolates from Taiyuan City, Shanxi Province, China, 2005 to 2016.
The study identified various AMR genes and mutations in Shigella isolates from Taiyuan City, including beta-lactamases (blaTEM-1, blaOXA-1, blaCTX-M-14, blaCTX-M-55), quinolone resistance genes (qnrS1), aminoglycoside resistance genes (aac(3)-IId), tetracycline resistance genes (tetA, tetB), macrolide resistance genes (mphA, ermB), and chloramphenicol resistance gene (catI). Mutations in gyrA and parC were associated with fluoroquinolone resistance.
Characterization of multidrug and heavy metal resistance of carbapenemases producing Klebsiella pneumoniae from poultry samples in Bangladesh.
The study identified multiple AMR genes, including bla TEM, bla SIM-1, bla IMP-4, bla OXA-48, and qnr B, in carbapenemase-producing Klebsiella pneumoniae isolates from poultry in Bangladesh, highlighting the prevalence of multidrug resistance.
Multidrug-resistant non-typhoidal Salmonella of public health significance recovered from migratory birds in Bangladesh.
The study identified multidrug-resistant non-typhoidal Salmonella in migratory birds in Bangladesh, highlighting the presence of various AMR genes such as blaCARB-2, floR, sul1, tet(G), dfrA1, and mutations in gyrA and parC associated with quinolone resistance.
Multidrug-resistant non-typhoidal Salmonella of public health significance recovered from migratory birds in Bangladesh.
The study identified multidrug-resistant non-typhoidal Salmonella in migratory birds in Bangladesh, highlighting the presence of various AMR genes such as blaCARB-2, floR, sul1, tet(G), dfrA1, and mutations in gyrA and parC associated with quinolone resistance.
Hospital and community wastewater as a source of multidrug-resistant ESBL-producing Escherichia coli.
The study identifies several AMR genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-1, bla GES-5, bla OXA-244, qnrS1, qnrB4, aac(3)-IId, aph(3'')-Ib, aph(6)-Id, catA1, cmlA1, and bla TEM-1, which confer resistance to various antibiotics in multidrug-resistant ESBL-producing E. coli isolates from hospital and environmental sources.
Escherichia coli ST2797 Is Abundant in Wastewater and Might Be a Novel Emerging Extended-Spectrum Beta-Lactamase E. coli.
The study identifies E. coli ST2797 as a multidrug-resistant clone abundant in wastewater, carrying resistance genes blaTEM-1B, sul2, dfrA7, and tet(B), which confer resistance to ampicillin, sulfonamides, trimethoprim, and tetracycline, respectively.
Modulatory Effect of Competitive Exclusion on the Transmission of ESBL E. coli in Chickens.
The study identified the blaTEM gene as a significant factor in the resistance of ESBL-producing E. coli isolates to beta-lactam antibiotics, and the use of the CE product Gro2MAX effectively reduced the excretion and transmission of these resistant strains.
Source-tracking ESBL-producing bacteria at the maternity ward of Mulago hospital, Uganda.
The study identified bla CTX-M, bla TEM, bla SHV, bla VIM, bla IMP, and bla NDM genes as the primary drivers of extended-spectrum beta-lactamase (ESBL) and carbapenemase resistance in E. coli, K. pneumoniae, and Enterobacter spp. isolates from the maternity ward of Mulago Hospital, Uganda.
Isolation of Hv-CRKP with co-production of three carbapenemases (bla(KPC), bla(OXA-181) or (OXA-232), and bla(NDM-1)) and a virulence plasmid: a study from a Chinese tertiary hospital.
The study identifies the co-production of three carbapenemases (bla(KPC), bla(OXA-181) or (OXA-232), and bla(NDM-1)) in hypervirulent carbapenem-resistant Klebsiella pneumoniae (Hv-CRKP) isolates, highlighting the emergence of multidrug-resistant strains with hypervirulence traits.
Blab(TEM)-positive Salmonella enterica serovars Agona and Derby are prevalent among food-producing animals in Chongqing, China.
Escherichia ruysiae May Serve as a Reservoir of Antibiotic Resistance Genes across Multiple Settings and Regions.
Evaluation of the synergistic effect of chitosan metal ions (Cu(2+)/Co(2+)) in combination with antibiotics to counteract the effects on antibiotic resistant bacteria.
The study identifies several antibiotic resistance genes, including mecA, blaz, pbp-4, pbp-1, blaTEM, blaCMY, and blaSHV, which are involved in resistance to penicillin in Staphylococcus aureus and Escherichia coli. These genes show reduced expression when treated with chitosan-metal ion nanoparticles in combination with antibiotics.
Role of multidrug resistance and co-resistance on a high percentage of streptomycin resistance in Escherichia coli isolated from chicken meats in Japan.
The study identifies multiple AMR genes, including strA/strB, blaTEM, tetB, aphA1, dfrA14, dfrA17, and cat1, which contribute to multidrug resistance in Escherichia coli isolated from chicken meats in Japan.
Phenotypic and molecular characterization of beta-lactam resistant Multidrug-resistant Enterobacterales isolated from patients attending six hospitals in Northern Nigeria.
The study identified bla CTX-M-15, bla TEM-1B, and bla NDM-1 as the most prevalent beta-lactam resistance genes in multidrug-resistant Enterobacterales isolates from Northern Nigeria, highlighting the significance of these genes in antimicrobial resistance.
Molecular Characterization and Prevalence of Antimicrobial-Resistant Escherichia coli Isolates Derived from Clinical Specimens and Environmental Habitats.
The study identified several AMR genes in E. coli isolates from clinical and environmental sources, including bla CTX-M-group 1, bla CTX-M-group 9, bla TEM, bla SHV, bla OXA-48, bla CMY-2, bla FOX, and sul1. These genes conferred resistance to various antibiotics such as beta-lactams, sulfamethoxazole-trimethoprim, and others.
Characterization of extended spectrum β-lactamase producing Escherichia coli strains isolated from urogenital system of dogs in Van province of Turkey.
The study identified bla TEM, bla SHV, and bla CTX-M group 1 genes in ESBL-producing E. coli isolates from dogs, highlighting the prevalence of extended-spectrum β-lactamase resistance.
The fecal carriage rate of extended-spectrum beta-lactamase-producing or carbapenem-resistant Enterobacterales among Japanese infants in the community at the 4-month health examination in a rural city.
The study identified blaCTX-M-9, blaCTX-M-1, and blaTEM genes as the primary resistance mechanisms in ESBL-E isolates from Japanese infants, with blaCTX-M-9 being the most prevalent.
Phylodynamics Uncovers the Transmission of Antibiotic-Resistant Escherichia coli between Canines and Humans in an Urban Environment.
The study identifies several AMR genes, including bla TEM-1B, bla CTX-M-15, bla CTX-M-55, bla CTX-M-27, and mdf(A), in antibiotic-resistant E. coli isolates from human and canine fecal samples in San Francisco. These genes confer resistance to various antibiotics, highlighting the transmission of AMR between canines and humans.
Food risk associated with vegetable consumption, exposure to antimicrobial-resistant strains and pesticide residues.
The study identified several antimicrobial resistance genes in AMR strains isolated from vegetables, including blaTEM, tetA, tetW, tetC, tetD, tetB, qnrS, and sulI. These genes conferred resistance to various antibiotics such as ampicillin, amoxicillin/clavulanic acid, tetracycline, ciprofloxacin, nalidixic acid, and trimethoprim/sulfamethoxazole.
Multi-Instrumental Analysis Toward Exploring the Diabetic Foot Infection Microbiota.
The study identified various beta-lactamase genes, including TEM, SHV, and CTX-M-9, in Gram-negative isolates from diabetic foot infections, highlighting the prevalence of extended-spectrum beta-lactamase (ESBL) production.
Multi-Instrumental Analysis Toward Exploring the Diabetic Foot Infection Microbiota.
The study identified various beta-lactamase genes, including TEM, SHV, and CTX-M-9, in Gram-negative isolates from diabetic foot infections, highlighting the prevalence of extended-spectrum beta-lactamase (ESBL) production.
Molecular characterization of multidrug-resistant non-typeable Haemophilus influenzae with high-level resistance to cefuroxime, levofloxacin, and trimethoprim-sulfamethoxazole.
The study identified several AMR genes and mutations in multidrug-resistant non-typeable Haemophilus influenzae, including blaTEM-1, blaROB-1, tet(B), mef(A), and various mutations in genes such as ftsI, lpoA, mrdA, mepA, pbpG, gyrA, gyrB, parC, parE, and folA, which are associated with resistance to cefuroxime, amoxicillin-clavulanate, levofloxacin, ciprofloxacin, and trimethoprim-sulfamethoxazole.
Urinary Plasmids Reduce Permissivity to Coliphage Infection.
Urinary E. coli plasmids reduce permissivity to coliphage infection. Specific plasmid-encoded genes such as bla TEM-1B, aadA5, aac(6′)-Ib-cr, tet(B), sul2, dfrA17, mph(A), qacE, catB3, traT, and senB contribute to antibiotic resistance and phage resistance.
Growth in a biofilm promotes conjugation of a bla (NDM-1)-bearing plasmid between Klebsiella pneumoniae strains.
The study identifies the bla NDM-1 gene on the plasmid pCPE16_3 as a key contributor to carbapenem resistance in Klebsiella pneumoniae, demonstrating that biofilm growth enhances the conjugative transfer of this plasmid.
Temporal dynamics of genetically heterogeneous extended-spectrum cephalosporin-resistant Escherichia coli bloodstream infections.
The study identifies bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, and bla CTX-M-14 as the dominant beta-lactamase genes conferring extended-spectrum cephalosporin resistance in E. coli bloodstream infections. Additional genes such as bla TEM-19, bla SHV-12, bla OXA-232, and bla NDM-5 were also characterized.
From Farm to Fork: Persistence of Clinically Relevant Multidrug-Resistant and Copper-Tolerant Klebsiella pneumoniae Long after Colistin Withdrawal in Poultry Production.
The study identified silA and pcoD genes associated with copper tolerance in Klebsiella pneumoniae isolates from poultry, and numerous chromosomal mutations linked to colistin resistance.
Case report: A successfully treated case of community-acquired urinary tract infection due to Klebsiella aerogenes in Bangladesh.
The study identifies several AMR genes in a multidrug-resistant Klebsiella aerogenes strain, including genes conferring resistance to aminoglycosides, beta-lactams, fluoroquinolones, and others. The strain was found to be susceptible to carbapenems and polymyxins.
There are three major Neisseria gonorrhoeae beta-lactamase plasmid variants which are associated with specific lineages and carry distinct TEM alleles.
The study identified three major Neisseria gonorrhoeae beta-lactamase plasmid variants (p bla .1, p bla .2, and p bla .3) that carry distinct TEM alleles, with p bla .1 predominantly associated with TEM-1, p bla .2 with TEM-1 and TEM-135, and p bla .3 with TEM-135.
Investigation of multidrug-resistant plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates from Pakistan.
The study identified 34 antimicrobial resistance genes (ARGs) in multidrug-resistant (MDR) plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates in Pakistan, including bla NDM-1, bla OXA-48, and various beta-lactamases, aminoglycoside resistance genes, and others.
Dominance of Escherichia coli sequence types ST73, ST95, ST127 and ST131 in Australian urine isolates: a genomic analysis of antimicrobial resistance and virulence linked to F plasmids.
The study identified various antimicrobial resistance genes in E. coli isolates from Australian urine samples, including blaCTX-M-15, blaCTX-M-14, blaTEM-28, sul1, sul2, sul3, dfrA17, dfrA5, dfrA1, dfrB4, tetA, tetB, mphA, cmlA1, cmlA5, catB3, sat2, qnrD1, fosA7, aac(3)-IId, aac(3)-IIe, aph(3')-IIa, aph(6)-Id, ant(3'')-IIa, intI1, and intI2. These genes were associated with resistance to various antibiotics such as beta-lactams, sulfonamides, trimethoprim, tetracycline, macrolides, chloramphenicol, streptothricin, quinolones, fosfomycin, and aminoglycosides.
Detection of Extended-spectrum beta-lactamase-producing Escherichia coli isolates by isothermal amplification and association of their virulence genes and phylogroups with extraintestinal infection.
The study identified bla CTX-M, bla TEM, bla OXA, and bla SHV genes in ESBL-ExPEC isolates, with bla CTX-M being the most prevalent. The developed isothermal assays showed high sensitivity and specificity for detecting these genes.
Inter-species competition of surface bacterial flora of pomegranate and their role in spoilage.
The study identified blaTEM as a prevalent antibiotic resistance gene among pomegranate surface bacteria, indicating their potential to confer resistance to beta-lactam antibiotics such as penicillin and cephalosporin.
Antimicrobial Resistance Profiles, Virulence Determinants, and Biofilm Formation in Enterococci Isolated from Rhesus Macaques (Macaca mulatta): A Potential Threat for Wildlife in Bangladesh?
The study identified the blaTEM gene in Enterococcus faecalis and E. faecium isolates from rhesus macaques in Bangladesh, which conferred resistance to penicillin, ampicillin, and rifampin. Multidrug resistance was prevalent among the isolates.
Interference with Bacterial Conjugation and Natural Alternatives to Antibiotics: Bridging a Gap.
The study identified the blaTEM gene as a key factor in beta-lactam resistance, demonstrating its presence in transconjugant colonies through PCR analysis.
Incidence and Genomic Background of Antibiotic Resistance in Food-Borne and Clinical Isolates of Salmonella enterica Serovar Derby from Spain.
The study identified several AMR genes, including aadA2, sul1, tet(A), tet(B), tet(C), blaTEM-1, and fosA7.3, in Salmonella enterica serovar Derby isolates from Spain. These genes were associated with resistance to streptomycin, sulfonamides, tetracycline, ampicillin, and fosfomycin. Additionally, a point mutation in the gyrA gene was linked to nalidixic acid resistance.
The emergence of multi-drug resistant and virulence gene carrying Escherichia coli strains in the dairy environment: a rising threat to the environment, animal, and public health.
The study identified multidrug-resistant Escherichia coli strains carrying various antibiotic resistance genes (ARGs) and virulence-associated genes (VAGs) in the dairy environment, highlighting the potential threat to human, animal, and environmental health.
The optimized carbapenem inactivation method for objective and accurate detection of carbapenemase-producing Acinetobacter baumannii.
The study identifies and characterizes several carbapenemase-encoding genes, including bla TEM, bla SHV, bla KPC, bla OXA-23-like, and bla OXA-51-like, in carbapenem-resistant Acinetobacter baumannii isolates.
The impact of applying various de novo assembly and correction tools on the identification of genome characterization, drug resistance, and virulence factors of clinical isolates using ONT sequencing.
The study evaluates the impact of various de novo assembly and read correction tools on the identification of antimicrobial resistance (AMR) genes, plasmids, and virulence factors in clinical Escherichia coli isolates using Oxford Nanopore sequencing. It highlights the effectiveness of Flye and Canu in detecting AMR genes and the importance of read correction tools like Medaka and Racon in improving assembly quality and AMR gene detection.
The impact of applying various de novo assembly and correction tools on the identification of genome characterization, drug resistance, and virulence factors of clinical isolates using ONT sequencing.
The study evaluates the impact of various de novo assembly and read correction tools on the identification of antimicrobial resistance (AMR) genes, plasmids, and virulence factors in clinical Escherichia coli isolates using Oxford Nanopore sequencing. It highlights the effectiveness of Flye and Canu in detecting AMR genes and the importance of read correction tools like Medaka and Racon in improving assembly quality and AMR gene detection.
The impact of applying various de novo assembly and correction tools on the identification of genome characterization, drug resistance, and virulence factors of clinical isolates using ONT sequencing.
The study evaluates the impact of various de novo assembly and read correction tools on the identification of antimicrobial resistance (AMR) genes, plasmids, and virulence factors in clinical Escherichia coli isolates using Oxford Nanopore sequencing. It highlights the effectiveness of Flye and Canu in detecting AMR genes and the importance of read correction tools like Medaka and Racon in improving assembly quality and AMR gene detection.
Prevalence of AmpC, ESBL, and colistin resistance genes in Enterobacterales isolated from ready-to-eat food in Algeria.
The study identified the presence of various beta-lactamase genes (bla CTX-M, bla CMY-2, bla TEM, bla OXA-1, and bla SHV) and the mcr-1 gene in Enterobacterales isolated from ready-to-eat foods in Algeria. These genes confer resistance to multiple antibiotics, highlighting the potential public health concerns associated with antimicrobial resistance in food products.
Prevalence of Antimicrobial Resistance Among the Hydrogen Sulfide Producing Bacteria Isolated on XLD Agar from the Poultry Fecal Samples.
The study identified the presence of tetracycline resistance gene tetA and beta-lactamase gene blaTEM in hydrogen sulfide-producing bacteria isolated from poultry fecal samples, indicating the prevalence of multidrug-resistant bacteria in poultry environments.
Drug Resistance, Characterization and Phylogenetic Discrepancy of Salmonella enterica Isolates from Distinct Sources.
The study identified several AMR genes in Salmonella enterica isolates from clinical and animal sources, including catA1, blaTEM, and tetC, which confer resistance to chloramphenicol, ampicillin, and tetracycline, respectively.
Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.
The study identified various AMR genes in multidrug-resistant Gram-negative pathogens, highlighting the prevalence of bla CTX-M-15, bla CMY-42, bla NDM-5, aadA, bla TEM-1B, bla OXA-232, bla NDM-1, rmtB, rmtC, bla VEB, bla VIM-2, aph(3'), strA/B, bla OXA-23, aph (3′), catB, dfrB, bla VIM-2, fosA, oqxA, oqxB, bla OXA-23, bla CARB, bla OXA-91, bla OXA-51, bla PAO, bla SHV, aph (3′)-Ib, aph (6)-Id, mphE, msrE, ermB, mphA, aadA, rmtB, qnrB, dfrA, sul1, sul2, and fosA7.
Extended-spectrum beta-lactamase-producing E. coli from retail meat and workers: genetic diversity, virulotyping, pathotyping and the antimicrobial effect of silver nanoparticles.
The study identified multiple AMR genes in ESBL-producing E. coli from retail meat and workers, including bla IMP, bla TEM, bla CTX-M-1, bla VIM, bla NDM, tetA (A), tetA (B), sul, flo R, and mcr-1. These genes conferred resistance to various antibiotics such as β-lactams, tetracycline, sulfonamides, fluoroquinolones, and colistin.
Prevalence of multidrug-resistant and extensively drug-resistant phenotypes of Gram-negative bacilli isolated in clinical specimens at Centre Hospitalo-Universitaire Ibn Rochd, Morocco.
The study identified the presence of bla CTX-M, bla SHV, bla TEM, bla OXA-48, and bla NDM genes in Enterobacteriaceae isolates, contributing to multidrug resistance. bla CTX-M was the most prevalent, followed by bla OXA-48 and bla NDM.
Prevalence of multidrug-resistant and extended-spectrum beta-lactamase-producing Escherichia coli from chicken farms in Egypt.
The study found that 56% of chickens had E. coli infections, with 65.7% being ESBL producers. The bla TEM and bla SHV genes were detected in 60% and 35% of ESBL-producing E. coli isolates, respectively.
Molecular characterization and antibiotic resistance profile of ESBL-producing Escherichia coli isolated from healthy cow raw milk in smallholder dairy farms in Bangladesh.
The study identified ESBL-producing E. coli in raw milk from healthy cows in Bangladesh, with bla CTX-M-1, bla TEM, and bla SHV being the predominant genes. High resistance to various antibiotics was observed, highlighting the public health risk.
High rate of multidrug resistance and integrons in Escherichia coli isolates from diseased ducks in select regions of China.
The study identified a high rate of multidrug resistance in E. coli isolates from diseased ducks in China, with several AMR genes such as bla TEM, bla CTX-M, qnrS, aadA1, sul1, sul2, tet A, floR, mcr-1, intI1, and intI2 being characterized.
Prevalence of antibiotic-resistant Gram-negative bacteria having extended-spectrum beta-lactamase phenotypes in polluted irrigation-purpose wastewaters from Indian agro-ecosystems.
The study identified the prevalence of antibiotic-resistant Gram-negative bacteria with extended-spectrum beta-lactamase (ESBL) phenotypes in irrigation-purpose wastewaters from Himachal Pradesh, India. Six isolates were found to be ESBL-positive, including Enterobacter spp., Escherichia coli, Shigella sp., and Citrobacter sp. The ESBL genes detected were bla CTX-M and bla TEM, which confer resistance to various β-lactam antibiotics.
Poultry production as the main reservoir of ciprofloxacin- and tigecycline-resistant extended-spectrum beta-lactamase (ESBL)-producing Salmonella enterica serovar Kentucky ST198.2-2 causing human infections in China.
The study identifies several AMR genes and mutations in Salmonella enterica serovar Kentucky ST198.2-2, including blaCTX-M-14b, blaCTX-M-55, blaTEM-1B, aadA7, aph(3')-Ia, aac(3)-IId, rmtB, tet(A), sul1, dfrA14, floR, lnu(F), mph(A), arr-2, and fosA3, which confer resistance to various antibiotics. Mutations in gyrA and parC also contribute to fluoroquinolone resistance.
Isolation and characterization of multidrug resistant Gallibacterium anatis biovar haemolytica strains from Polish geese and hens.
The study identified 25 different antimicrobial resistance genes in multidrug-resistant Gallibacterium anatis biovar haemolytica strains from Polish geese and hens, including tetB, blaTEM-1, blaROB-1, floR, sul2, sul3, dfrK, aadA1, aadA2, aph(3)-la, aph(3)-lb, aph(6)-ld, sat2, dfrA14, dfrA32, merC, merP, merR, merT, qacL, and cmlA1.
Occurrence of Acinetobacter baumannii genomic resistance islands (AbGRIs) in Acinetobacter baumannii strains belonging to global clone 2 obtained from COVID-19 patients.
The study identified several AMR genes within AbGRIs in GC2 A. baumannii isolates from COVID-19 patients, including strA, strB, tetA(B), tetR(B), sul2, oxa23, aacC1, aadA1, blaTEM, armA, aacA4, aphA1b, and sul1, which confer resistance to various antibiotics such as aminoglycosides, tetracyclines, sulfonamides, carbapenems, and beta-lactams.
Clinically Isolated β-Lactam-Resistant Gram-Negative Bacilli in a Philippine Tertiary Care Hospital Harbor Multi-Class beta-lactamase Genes.
The study identified multiple beta-lactamase genes in β-lactam-resistant Gram-negative bacilli from a Philippine hospital, highlighting the co-harbor of multi-class beta-lactamases and the presence of cryptic metallo-beta-lactamases in carbapenem-susceptible isolates.
Antimicrobial Resistance and Biofilm Formation of Escherichia coli Isolated from Pig Farms and Surroundings in Bulgaria.
The study identified the presence of beta-lactamase-producing genes ampC and blaTEM in E. coli isolates from pig farms in Bulgaria, indicating resistance to penicillins.
High Levels of Antibiotic Resistance in MDR-Strong Biofilm-Forming Salmonella Typhimurium ST34 in Southern China.
The study identifies multiple AMR genes and mutations in Salmonella Typhimurium ST34, including gyrA, parC, oqxAB, aac(6')-Ib-cr, qnrB, bla TEM, bla CTX-M, bla OXA, mcr-1, and bla NDM-5, highlighting the high levels of antibiotic resistance and biofilm formation in this strain.
Co-localization of clinically relevant antibiotic- and heavy metal resistance genes on plasmids in Klebsiella pneumoniae from marine bivalves.
The study identifies multiple antibiotic resistance genes (ARGs) and heavy metal resistance genes (HMRGs) co-localized on plasmids in Klebsiella pneumoniae isolated from marine bivalves, highlighting the potential for co-selection of these genes in the marine environment.
Plasmids conferring resistance to extended-spectrum beta-lactamases including a rare IncN+IncR multireplicon carrying bla(CTX-M-1) in Escherichia coli recovered from migrating barnacle geese ( Branta leucopsis).
The study identified several AMR genes in ESBL/AmpC-producing E. coli isolates from barnacle geese, including bla(CTX-M-1), bla(CTX-M-15), bla(CMY-2), aadA2b, lnu(F), and qnrS1, which confer resistance to various beta-lactams, aminoglycosides, lincomycin, and quinolones.
ESBL and carbapenemase-producing Enterobacteriaceae in infectious pleural effusions: current epidemiology at Hôpital du Mali.
The study identified bla TEM as the most common ESBL gene and bla NDM-1 as a carbapenemase gene in Enterobacteriaceae causing pleural effusions in Mali.
Clonal expansion and rapid characterization of Klebsiella pneumoniae ST1788, an otherwise uncommon strain spreading in Wales, UK.
The study identified several AMR genes in Klebsiella pneumoniae ST1788, including blaSHV-232, blaCTX-M-15, blaCTX-M-266, blaOXA-1, blaTEM-1, aac(3')-lla, aac(6')-lb-cr, strA, strB, qnrB1, dfrA14, sul2, and blaOXA-48. These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, trimethoprim, sulfamethoxazole, and carbapenems.
Impact of acquired broad-spectrum beta-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam beta-lactamase inhibitors in Escherichia coli.
The study evaluates the impact of various beta-lactamases on the susceptibility of Escherichia coli to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and their combinations with beta-lactamase inhibitors avibactam and taniborbactam.
Impact of acquired broad-spectrum beta-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam beta-lactamase inhibitors in Escherichia coli.
The study evaluates the impact of various beta-lactamases on the susceptibility of Escherichia coli to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and their combinations with beta-lactamase inhibitors avibactam and taniborbactam.
Unraveling virulence determinants in extended-spectrum beta-lactamase-producing Escherichia coli from East Africa using whole-genome sequencing.
The study identified several AMR genes in ESBL-producing E. coli isolates from Uganda and Tanzania, including blaCTX-M-15, blaCTX-M-27, blaTEM-1B, mdfA, tet(B), sul1, tet(A), and sul2, which confer resistance to beta-lactams, fluoroquinolones, third-generation cephalosporins, chloramphenicol, tetracyclines, and sulfonamides.
Isolation and Characterization of Carbapenem-Resistant Escherichia coli Carrying bla(NDM) and mcr-1 from Recurrent Urinary Tract Infection Patient.
The study identifies carbapenem-resistant E. coli isolates carrying bla NDM-1, bla NDM-5, mcr-1, and other resistance genes, highlighting their multidrug-resistant nature and the need for monitoring.
Inhibition of beta-lactamase function by de novo designed peptide.
The study presents a novel 30-mer peptide (pep3) that effectively inhibits the activity of class A beta-lactamases from Escherichia coli (TEM-1) and Enterobacter cloacae.
Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding.
The study identifies beta-lactamases TEM-1, SHV-11, and NDM-1 as targets for aggregation-induced inactivation using synthetic peptides, demonstrating restored susceptibility to beta-lactam antibiotics in resistant clinical isolates.
Global distribution of antimicrobial resistance in Salmonella Typhi
The study identifies the emergence of azithromycin resistance in Salmonella Typhi due to mutations in the acrB gene, particularly the R717Q mutation. It also notes the widespread presence of ciprofloxacin non-susceptibility and extensive drug resistance (XDR) in certain regions, primarily linked to specific genotypes and mutations in gyrase and topoisomerase genes.
Genomic classification and antimicrobial resistance profiling of Streptococcus pneumoniae and Haemophilus influenza isolates associated with paediatric otitis media and upper respiratory infection.
The study identified beta-lactamase genes blaTEM-1 and blaROB-1 in Haemophilus influenzae isolates, which were validated through WGS-based prediction and clinical testing.
Phenotypic and genotypic antimicrobial resistance correlation and plasmid characterization in Salmonella spp. isolates from Italy reveal high heterogeneity among serovars.
The study identified several antimicrobial resistance genes including blaTEM-1B, sul1, sul2, tetA, tetB, and others in Salmonella isolates from Italy, highlighting the diversity of resistance mechanisms among different serovars.
Molecular characterization of invasive Streptococcus pneumoniae clinical isolates from a tertiary children's hospital in eastern China.
The study identified multiple AMR genes in invasive S. pneumoniae isolates, including erm(B), mef(A), msr(D), tet(M), cat-TC, and blaTEM-116, which conferred resistance to erythromycin, tetracycline, chloramphenicol, and beta-lactam antibiotics. All isolates exhibited multidrug resistance.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Multidrug-Resistant Escherichia coli from Raw Cow Milk in Namwala District, Zambia: Public Health Implications.
The study identified multidrug-resistant E. coli in raw cow milk from Namwala District, Zambia, harboring bla CTX-M and bla TEM genes, which confer resistance to cefotaxime.
Analyses of Extended-Spectrum-β-Lactamase, Metallo-β-Lactamase, and AmpC-β-Lactamase Producing Enterobacteriaceae from the Dairy Value Chain in India.
The study identified several β-lactamase genes, including bla CMY, bla MOX, bla FOX, bla EBC, bla DHA, bla CTX-M1, bla SHV, bla TEM, bla VIM, bla IMP, bla SPM, bla SIM, and bla GIM, in Enterobacteriaceae isolates from milk samples in India, highlighting the presence of multidrug-resistant bacteria in the dairy value chain.
Uropathogenic Escherichia coli (UPEC)-Associated Urinary Tract Infections: The Molecular Basis for Challenges to Effective Treatment.
This review discusses the molecular basis of challenges to effective treatment of UPEC-associated urinary tract infections, focusing on virulence factors and antibiotic resistance mechanisms.
Resistance Profiles and Virulence Determinants in Biofilm-Forming Enterococcus faecium Isolated from Raw Seafood in Bangladesh.
The study identified the beta-lactamase gene blaTEM in 61% of E. faecium isolates from seafood in Bangladesh, indicating significant resistance to penicillin and ampicillin.
Domestic cats are potential reservoirs of multidrug-resistant human enteropathogenic E. coli strains in Bangladesh.
The study identified multidrug-resistant E. coli strains in domestic cats in Bangladesh, including strains with the blaTEM, blaCTX-M, and blaSHV2 genes, which confer resistance to various antibiotics.
Molecular identification of blaTEM and blaCTX-M genes in multidrug-resistant Escherichia coli found in milk samples from dairy cattle farms in Tulungagung, Indonesia.
The study identified blaTEM and blaCTX-M genes in multidrug-resistant Escherichia coli isolated from milk samples in dairy cattle farms in Tulungagung, Indonesia, highlighting the presence of extended-spectrum beta-lactamase (ESBL) producers.
The scope of antimicrobial resistance in residential aged care facilities determined through analysis of Escherichia coli and the total wastewater resistome.
The study identified several AMR genes in E. coli isolates from residential aged care facilities, including blaCTX-M-15, blaCTX-M-27, blaCTX-M-62, blaOXA-1, blaOXA-181, blaTEM-1, qnrS, aac(6')-Ib-cr, sul1, sul2, and dfrA1, which confer resistance to various antibiotics such as cephalosporins, fluoroquinolones, and sulfonamides.
Carbapenem resistance in extensively drug-resistant Salmonella enterica serovar Agona and AmpC β-lactamase-producing S. Infantis.
The study identifies the loss of porins OmpC_378 and OmpD as critical for carbapenem resistance in Salmonella strains producing AmpC or ESBL β-lactamases. It also characterizes several beta-lactamase genes, including bla CTX-M-55, bla TEM-1B, and bla CMY-2, as well as the efflux pump regulatory gene ramAp.
Protistan predation selects for antibiotic resistance in soil bacterial communities.
The study found that increasing protistan predation pressure significantly enhances the abundance and diversity of antibiotic resistance genes (ARGs) in soil bacterial communities, particularly multidrug efflux pump genes (oprJ, ttgB), tetracycline efflux pump gene (tetV), aminoglycoside resistance gene (aadA1), beta-lactamase genes (blaTEM, ampC-04), and glycopeptide resistance genes (vanWG, vanC-03).
Secondary Infection Surveillance with Metagenomic Next-Generation Sequencing in COVID-19 Patients: A Cross-Sectional Study.
The study identified several AMR genes, including blaKPC, blaSHV, blaCTX-M, blaTEM, blaOXA-23, blaOXA-51, blaNDM, mecA, and ErmB, which confer resistance to various antibiotics in clinically relevant pathogens.
Genetic determinants underlying the progressive phenotype of β-lactam/beta-lactamase inhibitor resistance in Escherichia coli.
In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales.
Xeruborbactam (XER) showed superior in vitro potency against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales when combined with various β-lactam antibiotics compared to other β-lactam/β-lactamase inhibitor combinations. XER effectively inhibited a wide range of β-lactamases, including metallo-β-lactamases (MBLs) and serine β-lactamases, enhancing the activity of antibiotics such as meropenem, cefepime, ceftolozane, ceftriaxone, aztreonam, piperacillin, and ertapenem.
Resistance profiles, virulence and antimicrobial resistance genes of XDR S. Enteritidis and S. Typhimurium.
The study identified multiple antimicrobial resistance genes including blaTEM, blaCTX-M, blaNDM, sul1, tetA, aadA1, and ereA in XDR S. Enteritidis and S. Typhimurium isolates from diseased broilers. These genes conferred resistance to various antibiotics such as beta-lactams, sulfonamides, tetracyclines, and aminoglycosides.
Facile synthesis of CuONPs using Citrus limon juice for enhancing antibacterial activity against methicillin-resistant Staphylococcus aureus, beta-lactamase and tetracycline-resistant Escherichia coli.
The study identifies the presence of methicillin-resistant Staphylococcus aureus, beta-lactamase-resistant Escherichia coli, and tetracycline-resistant Escherichia coli using PCR amplification of specific genes (mecA, blaTEM-1, and tetA).
The Resistance and Virulence Characteristics of Salmonella Enteritidis Strain Isolated from Patients with Food Poisoning Based on the Whole-Genome Sequencing and Quantitative Proteomic Analysis.
The study identified multiple antimicrobial resistance genes in the multidrug-resistant Salmonella Enteritidis strain 27A, including beta-lactamase blaTEM-194, aminoglycoside resistance genes aac(6)-Ib, aac(6)-If, aph(3”)-Ib, and aph(6)-Id, tetracycline resistance genes tetA, tetR, and tet34, and efflux pump genes acrA, acrB, tolC, oprM, mexE, mexF, macB, mdtG, mdtH, mdtL, mdtM, mdtK, rosA, emrA, emrR, ykkc, and vanRA.
Extensive Expression of the Virulome Related to Antibiotic Genotyping in Nosocomial Strains of Klebsiella pneumoniae.
The study identified several antibiotic resistance genes in multidrug-resistant Klebsiella pneumoniae strains, including beta-lactamases (bla TEM, bla SHV, bla CITM, bla CTXM-1), tetracycline resistance (tetA), sulfonamide resistance (sul1), aminoglycoside resistance (aac(3)-IV, aadA1), and others.
Prevalence and characterization of ESBL-producing Escherichia coli in healthy pregnant women and hospital environments in Benin: an approach based on Tricycle.
The study identified bla TEM, bla OXA-1, and bla SHV as the most prevalent ESBL-encoding genes in ESBL-producing E. coli isolates from healthy pregnant women and hospital effluents in Benin.
Revisiting the hydrolysis of ampicillin catalyzed by Temoneira-1 beta-lactamase, and the effect of Ni(II), Cd(II) and Hg(II).
The study revisits the hydrolysis of ampicillin by TEM-1 beta-lactamase and examines the effects of Ni(II), Cd(II), and Hg(II) on its catalytic activity and bacterial growth.
Detection of extended-spectrum beta-lactamase-producing Escherichia coli genes isolated from cat rectal swabs at Surabaya Veterinary Hospital, Indonesia.
The study identified the presence of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli strains carrying the TEM and CTX-M genes in cat rectal swabs from Surabaya City Veterinary Hospital, Indonesia.
Characterization of extended spectrum beta-lactamases in Colombian clinical isolates of non-typhoidal Salmonella enterica between 1997 and 2022.
The study identified the prevalence of extended-spectrum beta-lactamases (ESBLs) in Salmonella enterica isolates in Colombia, primarily mediated by bla CTX-M, bla TEM, and bla SHV genes, leading to resistance against third- and fourth-generation cephalosporins.
Antimicrobial resistance profiles of salmonella spp. and escherichia coli isolated from fresh nile tilapia (oreochromis niloticus) fish marketed for human consumption.
The study identified various antimicrobial resistance genes in Salmonella spp. and E. coli isolates from Nile tilapia, including beta-lactamases, tetracycline, sulfonamide, trimethoprim, and aminoglycoside resistance genes, indicating the presence of multidrug-resistant strains.
Genomic Analysis of Multidrug-Resistant Escherichia coli Strains Isolated in Tamaulipas, Mexico.
The study identified multiple antimicrobial resistance genes (ARGs) in multidrug-resistant E. coli strains isolated from human clinical, animal, and environmental sources in Tamaulipas, Mexico. These genes include beta-lactamases (bla CTX-M-15, bla OXA-1, bla TEM-1B, bla CMY-2), aminoglycoside resistance genes (aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aadA5, aac3-IIa), sulfonamide resistance genes (sul2, sul3), phenicol resistance gene (catB3), tetracycline resistance genes (tet(A), tet(B)), quaternary ammonium resistance genes (qacE, qacL), macrolide resistance genes (mdfA, mphA), and quinolone resistance gene (qnrB).
Comparative Genomic Analysis Reveals the Emergence of ST-231 and ST-395 Klebsiella pneumoniae Strains Associated with the High Transmissibility of bla(KPC) Plasmids.
The study identifies multiple AMR genes, including blaOXA-232, blaCTX-M-15, dfrA14, aac(6')-Ib-cr, and others, in K. pneumoniae isolates, highlighting the role of integrons and plasmids in the dissemination of resistance.
First Report and Characterization of the mcr-1 Positive Multidrug-Resistant Escherichia coli Strain Isolated from Pigs in Croatia.
The study reports the first mcr-1 positive multidrug-resistant E. coli strain isolated from pigs in Croatia. The strain was resistant to colistin, gentamicin, ampicillin, cefepime, cefotaxime, ceftazidime, sulfamethoxazole, chloramphenicol, nalidixic acid, and ciprofloxacin. The mcr-1 gene was located on an IncX4 plasmid, along with other resistance genes such as bla TEM-1B, bla CTX-M-1, aac(3)-IId, aph(3’)-Ia, aadA5, sul2, and catA1. Mutations in gyrA (S83L, D87N) and parC (A56T, S80I) were also identified, contributing to fluoroquinolone resistance.
The Molecular Characterization of bla(NDM-1)-Positive Acinetobacter baumannii Isolated in Central Greece.
The study identifies multiple AMR genes in blaNDM-1-positive Acinetobacter baumannii isolates, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, macrolide resistance genes, tetracycline resistance genes, trimethoprim resistance genes, and quaternary ammonium resistance genes.
Unveiling the genome of a high-risk pandrug-resistant Klebsiella pneumoniae emerging in the Brazilian Amazon Region, 2022.
The study identified a pandrug-resistant Klebsiella pneumoniae strain (Kp196) with a complex resistome comprising numerous acquired and intrinsic resistance mechanisms, including multiple beta-lactamases, aminoglycoside-modifying enzymes, quinolone resistance proteins, and mutations in genes involved in colistin, tigecycline, and fluoroquinolone resistance.
Evaluation of antibiotic resistance, toxin-antitoxin systems, virulence factors, biofilm-forming strength and genetic linkage of Escherichia coli strains isolated from bloodstream infections of leukemia patients.
The study identified bla CTX-M, bla TEM, bla SHV, bla OXA-48, qnr B, and qnr S genes as the main contributors to antibiotic resistance in E. coli strains isolated from bloodstream infections of leukemia patients.
Evolutionary "Crowdsourcing": Alignment of Fitness Landscapes Allows for Cross-species Adaptation of a Horizontally Transferred Gene.
The study characterizes the blaTEM gene, a beta-lactamase encoding gene, and examines its evolutionary landscape across three enteric species, revealing minimal gene-by-host interactions and demonstrating the potential for cross-species adaptation through horizontal gene transfer.
Gut acquisition of Extended-spectrum beta-lactamases-producing Klebsiella pneumoniae in preterm neonates: Critical role of enteral feeding, and endotracheal tubes in the neonatal intensive care unit (NICU).
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including blaSHV, blaTEM, blaCTX-M-1, blaCTX-M-2, blaCTX-M-9, and blaOXA-48, in Klebsiella pneumoniae isolates from preterm neonates. These genes were associated with resistance to multiple antibiotics, including amoxicillin, clavulanic acid-amoxicillin, cefotaxime, ceftazidime, and gentamicin. The study also found that enteral tube feeding and endotracheal tubes were significant risk factors for ESBL-KP colonization in the NICU.
Characterization of integrons, extended spectrum beta lactamases and genetic diversity among uropathogenic Escherichia coli isolates from Kerman, south east of Iran.
The study identified the presence of class I integrons and ESBLs, particularly bla CTX-M, bla TEM, and bla SHV, in uropathogenic E. coli isolates from Kerman, Iran. Additionally, various gene cassettes such as dfrA17-aadA5, aadA1-dfrA1, and others were detected, contributing to resistance against multiple antibiotics.
Persistent effects of intramammary ceftiofur treatment on the gut microbiome and antibiotic resistance in dairy cattle.
The study identified the persistence of extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M, blaCMY, and blaCfxA, in the gut microbiome of dairy cattle following intramammary ceftiofur treatment. These genes were associated with increased resistance to ceftiofur and were observed to persist for up to 9 weeks post-treatment.
Persistent effects of intramammary ceftiofur treatment on the gut microbiome and antibiotic resistance in dairy cattle.
The study identified the persistence of extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M, blaCMY, and blaCfxA, in the gut microbiome of dairy cattle following intramammary ceftiofur treatment. These genes were associated with increased resistance to ceftiofur and were observed to persist for up to 9 weeks post-treatment.
Fluoroquinolone resistance determinants in carbapenem-resistant Escherichia coli isolated from urine clinical samples in Thailand.
The study identified fluoroquinolone resistance determinants in carbapenem-resistant Escherichia coli isolates from urine samples in Thailand, highlighting the presence of genes such as aac(6')-Ib, bla_NDM-5, bla_CTX-M-15, and qnrS1, along with mutations in gyrA, parC, gyrB, and parE.
Distribution of ß-Lactamase Genes Among Multidrug-Resistant and Extended-Spectrum ß-Lactamase-Producing Diarrheagenic Escherichia coli from Under-Five Children in Ethiopia.
The study identified the presence of bla TEM, bla CTX-M, bla SHV, bla NDM, and bla OXA-48 genes in multidrug-resistant and extended-spectrum beta-lactamase-producing diarrheagenic Escherichia coli isolates from under-five children in Ethiopia, highlighting the emergence of these resistance genes in the region.
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
Characterization of the soil resistome and mobilome in Namib Desert soils.
The study identified two horizontally acquired antibiotic resistance genes, AAC(3')-la and blaTEM-116, in Namib Desert soils, highlighting the presence of resistance mechanisms against aminoglycosides and beta-lactam antibiotics.
Beta-lactam, aminoglycoside, and quinolone resistance in Escherichia coli strains isolated from shrimps and mussels in the Marmara Sea.
The study identified bla TEM and bla CTX-M-1 as ESBL genes, strB, aadA, aphA1, and aphA2 as aminoglycoside resistance genes, and aac(6')-Ib-cr as a quinolone resistance gene in E. coli isolates from shrimps and mussels in the Marmara Sea.
Resistome and virulome of high-risk pandemic clones of multidrug-resistant extra-intestinal pathogenic Escherichia coli (ExPEC) isolated from tertiary healthcare settings in Uganda.
The study identified various AMR genes in multidrug-resistant E. coli isolates, including blaCTX-M-15, blaTEM-1B, blaOXA-1, and others, which confer resistance to beta-lactams, aminoglycosides, sulfonamides, tetracyclines, macrolides, and quinolones. Additionally, chromosomal mutations in gyrA and parC were found to contribute to fluoroquinolone resistance.
Comparative analyses of the faecal resistome against β-lactam and quinolone antibiotics in humans and livestock using metagenomic sequencing.
The study identifies and characterizes the prevalence of beta-lactamase genes (bla TEM, bla OXA, bla CTX-M) and quinolone resistance gene (qnrS) in human and livestock gut microbiomes using metagenomic sequencing.
CRISPR-Cas9-mediated IncF plasmid curing in extraintestinal pathogenic Escherichia coli.
The study identified several AMR genes carried on IncF plasmids in MDR ExPEC strains, including bla TEM-1, aac(3)-IId, tet(A), aph(6)-Id, aph(3')-Ib, mphA, sul1, sul2, aadA5, dfrA17, strAB, qacEdelta1, bla CTX-M-14, bla CTX-M-15, catB3, bla OXA-1, bla CTX-M-27, and aac(6')-Ib-cr5. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, sulfonamides, and chloramphenicol.
Molecular Characterization and Antibiotic Susceptibility Pattern of Bacterial Strains Isolated From Wound of Patients With Diabetes.
The study identified bla CTX-M-1 and bla TEM genes in multidrug-resistant bacterial isolates from diabetic wound infections, indicating resistance to beta-lactam antibiotics such as ceftazidime and cefotaxime.
Molecular Epidemiology of Carbapenem Resistant Klebsiella Pneumoniae in Northern China: Clinical Characteristics, Antimicrobial Resistance, Virulence and Geographic Distribution.
The study identified several carbapenemase genes, including bla NDM-1, bla NDM-5, bla KPC-2, bla OXA-23, bla SME, and bla IMI, as well as extended-spectrum beta-lactamase genes such as bla CTX-M, bla SHV, and bla TEM, and AmpC beta-lactamase gene bla DHA, which contribute to carbapenem resistance in CRKP isolates from Shanxi Province.
Enterobacteriaceae isolates from clinical and household tap water samples: antibiotic resistance, screening for extended-spectrum, metallo- and ampC-beta-lactamases, and detection of bla(TEM,)bla(SHV) and bla(CTX-M) in Uyo, Nigeria.
The study identified the presence of blaTEM, blaSHV, and blaCTX-M genes in Enterobacteriaceae isolates from clinical and tap water samples in Uyo, Nigeria, highlighting the prevalence of extended-spectrum beta-lactamase (ESBL) producers and their association with multidrug resistance.
Transmission of β-lactamases in the pork food chain: A public health concern.
The study identified the presence of β-lactamase genes, including bla CTX-M1, bla CTX-M2, bla TEM, and bla SHV, in Escherichia coli isolates from the pork food chain, indicating the potential transmission of β-lactam resistance from farm to fork.
Dynamics of antimicrobial resistance and virulence of staphylococcal species isolated from foods traded in the Cape Coast metropolitan and Elmina municipality of Ghana.
The study identified multiple antimicrobial resistance genes in staphylococcal isolates from food samples, including genes conferring resistance to tetracycline, gentamicin, methicillin, erythromycin, and vancomycin. High prevalence of multidrug resistance was observed, highlighting the potential health risks associated with food-borne staphylococci.
Occurrence and temporal distribution of extended-spectrum beta-lactamase-producing Escherichia coli in clams from the Central Adriatic, Italy.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV12, bla CMY-2, bla TEM-1B, bla TEM-106, and bla TEM-126, which confer resistance to various β-lactam antibiotics. Other resistance genes such as aac(6′)-Ib-cr, qnrS1, tet(A), tet(B), tet(M), aadA5, aadA2b, sul1, sul2, sul3, dfrA17, dfrA5, dfrA14, dfrA12, mph(A), cmlA1, catA2, aac(3)-IIa, aac(3)-IId, and lnu(F) were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates from clams in the Central Adriatic.
Occurrence and temporal distribution of extended-spectrum beta-lactamase-producing Escherichia coli in clams from the Central Adriatic, Italy.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV12, bla CMY-2, bla TEM-1B, bla TEM-106, and bla TEM-126, which confer resistance to various β-lactam antibiotics. Other resistance genes such as aac(6′)-Ib-cr, qnrS1, tet(A), tet(B), tet(M), aadA5, aadA2b, sul1, sul2, sul3, dfrA17, dfrA5, dfrA14, dfrA12, mph(A), cmlA1, catA2, aac(3)-IIa, aac(3)-IId, and lnu(F) were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates from clams in the Central Adriatic.
Occurrence and temporal distribution of extended-spectrum beta-lactamase-producing Escherichia coli in clams from the Central Adriatic, Italy.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV12, bla CMY-2, bla TEM-1B, bla TEM-106, and bla TEM-126, which confer resistance to various β-lactam antibiotics. Other resistance genes such as aac(6′)-Ib-cr, qnrS1, tet(A), tet(B), tet(M), aadA5, aadA2b, sul1, sul2, sul3, dfrA17, dfrA5, dfrA14, dfrA12, mph(A), cmlA1, catA2, aac(3)-IIa, aac(3)-IId, and lnu(F) were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates from clams in the Central Adriatic.
Molecular epidemiology and pathogenomics of extended-spectrum beta-lactamase producing- Escherichia coli and - Klebsiella pneumoniae isolates from bulk tank milk in Tennessee, USA.
The study identified multiple AMR genes and mutations in ESBL-producing E. coli and K. pneumoniae isolates from bulk tank milk, highlighting the presence of multidrug-resistant strains with resistance to beta-lactams, fluoroquinolones, aminoglycosides, and tetracyclines.
Genetic characterization of a multidrug-resistant Salmonella enterica serovar Agona isolated from a dietary supplement in Germany.
The study identifies 23 antibiotic resistance genes (ARGs) in a multidrug-resistant Salmonella enterica serovar Agona isolate from a dietary supplement in Germany, conferring resistance to 12 different antibiotic classes. Key genes include blaSHV-12, aac(3)-Iig, aac(6')-Iic, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, dfrA19, qacEΔ1, ere(A), sul1, sul2, tet(D), mcr-9.1, catA2, arr, qnrS1, blaTEM-1, aac(3)-IIe, and floR.
Fecal carriage of extended-spectrum beta-lactamase-producing enterobacterales from hospitals and community settings in Gaza Strip, Palestine.
The study identified bla CTX-M, bla TEM, and bla SHV genes as the main contributors to extended-spectrum beta-lactamase (ESBL) production in Enterobacterales in Gaza Strip, with bla CTX-M being the most prevalent.
Characterization of beta-lactamase producing Enterobacterales isolated from an urban community wastewater treatment plant in Iran.
The study identified various beta-lactamase genes, including bla CTX-M, bla TEM, bla SHV, bla DHA, bla CIT, and bla FOX, in Enterobacterales isolates from a wastewater treatment plant in Iran, highlighting the presence of multidrug-resistant strains.
Escherichia coli from Human Wounds: Analysis of Resistance to β-Lactams and Expression of RND Efflux Pumps.
The study identified bla TEM, bla CTX-M, and bla AmpC genes as contributors to ampicillin resistance in E. coli isolates from human wounds. These genes were detected in resistant isolates and correlated with increased MIC values.
Comparison of the inoculum effect of in vitro antibacterial activity of Imipenem/relebactam and Ceftazidime/avibactam against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae.
The study evaluated the inoculum effect of Imipenem/relebactam (IMR) and Ceftazidime/avibactam (CZA) against ESBL-, KPC-, and AmpC-producing E. coli and K. pneumoniae. It identified several beta-lactamase genes, including bla TEM-1, bla AmpC, bla CTX-M-14, bla OXA-10, bla CTX-M-55, bla CMY-42, bla CTX-M-15, bla KPC-2, bla OXA-9, bla SHV-182, bla SHV-18, bla OXA-2, bla OKP-B-7, bla DHA-1, bla SHV-27, bla CTX-M-65, bla SHV-11, bla SHV-145, bla SHV-12, bla SHV-106, bla SHV-110, bla SHV106, and bla CTX-M-14, which confer resistance to ceftazidime and/or imipenem.
Antimicrobial resistance and genomic characteristics of Salmonella from broilers in Shandong Province.
The study identified multiple antimicrobial resistance genes in Salmonella isolates from broilers in Shandong Province, including tet(A), floR, cmlE, blaTEM, aph(4)-Ia, qnrS1, and mcr-1, highlighting the prevalence of multidrug-resistant strains.
Clostridium neonatale antimicrobial susceptibility, genetic resistance determinants, and genotyping: a multicentre spatiotemporal retrospective analysis.
The study identified several AMR genes in Clostridium neonatale, including erm(B), tet(O), tet(32), tet(M), bla TEM-116, bla CBP-1-like, and aph(3')-IIa, which confer resistance to clindamycin, tetracycline, cefotaxime, and gentamicin. These genes are associated with mobile genetic elements.
The secrets of environmental Pseudomonas aeruginosa in slaughterhouses: Antibiogram profile, virulence, and antibiotic resistance genes.
The study identified multiple antibiotic resistance genes in Pseudomonas aeruginosa isolates from slaughterhouses, including blaCTX-M, blaAmpC, blaSHV, blaNDM, IMP-1, aac(6')-Ib, ant(4')IIb, qnrB, tetA, mexY, TEM, and rmtC. These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, and tetracyclines.
Prevalence and antibiotics resistance status of Salmonella in raw meat consumed in various areas of Lahore, Pakistan.
The study identified the presence of bla TEM-1, catA1, and gyrA genes in Salmonella isolates from raw meat in Lahore, Pakistan, indicating resistance to Ampicillin, Chloramphenicol, and Quinolones.
Antimicrobial Resistance Profiles of Multidrug-Resistant Enterobacteria Isolated from Feces of Weaned Piglets.
The study identified the presence of various AMR genes, including bla TEM, bla SHV, bla CTX-M, tetA, and mcr-1, in multidrug-resistant enterobacteria isolated from weaned piglets. These genes were associated with resistance to beta-lactams, tetracycline, and colistin.
Genomic and proteomic analysis of Salmonella Enteritidis isolated from a patient with foodborne diarrhea.
The study identified multiple antimicrobial resistance genes in the Salmonella Enteritidis strain 31A, including blaTEM-194, aac(6')-Iaa, aph(3")-Ib, and sul2, which confer resistance to beta-lactam, aminoglycoside, and sulfonamide antibiotics.
Within-host genetic diversity of extended-spectrum beta-lactamase-producing Enterobacterales in long-term colonized patients.
The study characterizes various AMR genes, including bla CTX-M-15, bla TEM-1B, bla OXA-1, qnrB1, qnrS1, aph(6)-Id, aph(3”)-Ib, aac(3)-IIa, ant(3”)-Ia, dfrA14, dfrA1, aac(6’)-Ib-cr, tet(A), tet(D), sul2, sul1, fosA6, fosA_5, fosA_3, bla CTX-M-1, bla CTX-M-14, bla CTX-M-14b, bla CTX-M-8, bla CMY-2, bla TEM-190, aac(3)-IVa, aph(4)-Ia, and catB3_2, in ESBL-producing Enterobacterales isolates from long-term colonized patients.
Within-host genetic diversity of extended-spectrum beta-lactamase-producing Enterobacterales in long-term colonized patients.
The study characterizes various AMR genes, including bla CTX-M-15, bla TEM-1B, bla OXA-1, qnrB1, qnrS1, aph(6)-Id, aph(3”)-Ib, aac(3)-IIa, ant(3”)-Ia, dfrA14, dfrA1, aac(6’)-Ib-cr, tet(A), tet(D), sul2, sul1, fosA6, fosA_5, fosA_3, bla CTX-M-1, bla CTX-M-14, bla CTX-M-14b, bla CTX-M-8, bla CMY-2, bla TEM-190, aac(3)-IVa, aph(4)-Ia, and catB3_2, in ESBL-producing Enterobacterales isolates from long-term colonized patients.
Characterization of Riemerella anatipestifer Strains Isolated from Various Poultry Species in Poland.
The study identified several AMR genes in R. anatipestifer isolates, including aminoglycoside resistance genes (aph(3′)-VII, aac(3′)-IV, aadA, strA/strB), tetracycline resistance genes (tet(A), tet(B), tet(X)), erythromycin resistance gene (ermF), chloramphenicol resistance gene (cmlA), beta-lactam resistance gene (bla TEM), and sulfonamide resistance gene (sulI).
Predominance of Multidrug-Resistant Gram-Negative Bacteria Isolated from Supermarket Retail Seafood in Japan.
The study identified multiple AMR genes, including bla TEM-1, bla CTX-M-like, bla CTX-M-65, aac(6')-Ib, and mcr, in Gram-negative bacteria isolated from retail seafood in Japan, highlighting the prevalence of multidrug-resistant strains.
Prevalence of the bla(CTX-M) and bla(TEM) genes among extended-spectrum beta lactamase-producing Escherichia coli isolated from broiler chickens in Indonesia.
The study found that 94.1% of ESBL-producing E. coli isolates from broiler chickens in Indonesia harbored the bla(CTX-M) gene, and 38.2% harbored the bla(TEM) gene. Both genes were associated with resistance to beta-lactam antibiotics.
Early-Onset Infection Caused by Escherichia coli Sequence Type 1193 in Late Preterm and Full-Term Neonates.
The study identifies several AMR genes in E. coli ST1193 strains causing early-onset sepsis in neonates, including blaCTX-M-15, blaOXA-1, mph(A), aac(6')-Ib-cr, dfrA17, aph(6)-Id, aac(3)-IIa, aph(3”)-Ib, sul2, catB3, sitABCD, tet(B), and blaTEM-1B, which confer resistance to various antibiotics.
Genomic characterization of Salmonella isolated from retail chicken and humans with diarrhea in Qingdao, China.
The study identified 79 antimicrobial resistance genes (ARGs) in Salmonella isolates from retail chicken and humans with diarrhea in Qingdao, China, including aac(6')-Iaa, bla TEM-1B, tet(A), aph(6)-Id, aph(3")-Ib, sul2, floR, qnrS1, bla NDM-1, mcr-1.1, and mcr-9.1. These genes conferred resistance to various antibiotics such as aminoglycosides, beta-lactams, tetracyclines, sulfonamides, chloramphenicol, fluoroquinolones, carbapenems, and colistin.
Evolution of extended-spectrum beta-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years.
The study identifies various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-15, blaCTX-M-27, blaCTX-M-14, and others, in ST131 Escherichia coli isolates from a single hospital over 15 years. These genes are responsible for resistance to multiple β-lactam antibiotics and are carried on both plasmids and the chromosome. Mutations in genes such as ftsI, arnC, gloB, and fyuA were also found to contribute to resistance mechanisms.
Evolution of extended-spectrum beta-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years.
The study identifies various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-15, blaCTX-M-27, blaCTX-M-14, and others, in ST131 Escherichia coli isolates from a single hospital over 15 years. These genes are responsible for resistance to multiple β-lactam antibiotics and are carried on both plasmids and the chromosome. Mutations in genes such as ftsI, arnC, gloB, and fyuA were also found to contribute to resistance mechanisms.
Evolution of extended-spectrum beta-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years.
The study identifies various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-15, blaCTX-M-27, blaCTX-M-14, and others, in ST131 Escherichia coli isolates from a single hospital over 15 years. These genes are responsible for resistance to multiple β-lactam antibiotics and are carried on both plasmids and the chromosome. Mutations in genes such as ftsI, arnC, gloB, and fyuA were also found to contribute to resistance mechanisms.
Metagenomic assembly is the main bottleneck in the identification of mobile genetic elements.
The study evaluated the performance of tools for identifying mobile genetic elements (MGEs) and antimicrobial resistance genes (ARGs) in metagenomic data. It found that metagenomic assembly is the main bottleneck in accurately identifying MGEs and ARGs, with moderate precision and sensitivity for plasmids, phages, IS elements, and ARGs.
Low temperatures do not impair the bacterial plasmid conjugation on poultry meat.
The study demonstrates that non-pathogenic E. coli can acquire an IncB/O-plasmid carrying multiple antimicrobial resistance genes through conjugation on poultry meat, even at low temperatures. This highlights the potential risk of antimicrobial resistance spread through food products.
Interaction with a phage gene underlie costs of a beta-lactamase.
The study identifies that the fitness cost of the beta-lactamase gene bla TEM-116* in E. coli M114 is mitigated by mutations in the phage-encoded gene relA P1. These mutations, including I179S, reduce the cost of the bla TEM-116* plasmid, demonstrating an antagonistic interaction between the phage gene and the beta-lactamase.
Antimicrobial resistance, virulence profile, and genetic analysis of ESBL-producing Escherichia coli isolated from Nile tilapia in fresh markets and supermarkets in Thailand.
The study identified the presence of ESBL-producing E. coli in Nile tilapia, with the most prevalent AMR genes being bla TEM, tetA, and qnrS. These genes conferred resistance to ampicillin, tetracycline, and fluoroquinolones, respectively.
Genotypic characterization of extended spectrum beta-lactamase in gram negative bacterial contaminants of some door handles in Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun state.
The study identified blaTEM, blaCTX-M, and blaSHV genes in Gram-negative bacterial isolates from door handles, indicating the presence of extended-spectrum beta-lactamase (ESBL) producing bacteria in the hospital environment.
Prevalence, antibiotic resistance and molecular characterization of Staphylococcus aureus in ready-to-eat fruits and vegetables in Shanghai, China.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from ready-to-eat fruits and vegetables in Shanghai, China, including genes conferring resistance to beta-lactams, fluoroquinolones, aminoglycosides, lincosamides, and fosfomycin.
Prevalence and antimicrobial resistance profiles of extended-spectrum beta-lactamase-producing Escherichia coli in East Tennessee dairy farms.
The study identified extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in East Tennessee dairy farms, with high prevalence and multidrug resistance. Key AMR genes included blaCTX-M, blaSHV, and blaTEM, which conferred resistance to beta-lactam antibiotics such as ampicillin and ceftriaxone.
Genotypic Characterization of Uropathogenic Escherichia coli from Companion Animals: Predominance of ST372 in Dogs and Human-Related ST73 in Cats.
The study identified several AMR genes and mutations in uropathogenic E. coli isolates from companion animals, including blaTEM-1B, sul2, tet(A), qnrS1, aac(6')-Ib-c, qnrS2, qnrB19, qnrB4, CTX-M-15, CTX-M-27, CMY-2, DHA-1, blaEC, blaEC-6, and mcr-4.6. Mutations in gyrA (S83L, D87N) and parC (S80I) were also found to confer fluoroquinolone resistance.
Rapid and visual identification of beta-lactamase subtypes for precision antibiotic therapy.
The study presents a paper-based sensor (BSV sensor) capable of rapidly and visually identifying beta-lactamase subtypes, including BSBL, ESBL, AmpC, and carbapenemases, enabling precise antibiotic therapy.
Genomic investigation unveils high-risk ESBL producing Enterobacteriaceae within a rural environmental water body.
The study identifies several AMR genes and mutations in ESBL-producing Enterobacteriaceae isolated from a rural environmental water body in India, highlighting the presence of multidrug-resistant strains with genes such as bla VEB-6, bla SHV-12, bla NDM-1, bla CTX-M, and mcr-9, along with mutations in ompK 36 and gyrA.
Multiplex Microarrays in 96-Well Plates Photoactivated with 4-Azidotetrafluorobenzaldehyde for the Identification and Quantification of beta-lactamase Genes and Their RNA Transcripts.
The study developed a novel microarray technique using photoactivated 96-well plates to identify and quantify beta-lactamase genes and their RNA transcripts. The method successfully detected various beta-lactamase genes, including ESBLs, inhibitor-resistant beta-lactamases, and carbapenemases, demonstrating high specificity and reproducibility.
Distribution of bacterial community structures and spread of antibiotic resistome at industrially polluted sites of Mini River, Vadodara, Gujarat, India.
The study identified the presence of antibiotic resistance genes (ARGs) such as sul1, sul2, blaTEM, and aac(6')-Ib-Cr in the Mini River, highlighting the spread of antibiotic resistance in industrially polluted sites.
Dissemination of mcr-1 and β-lactamase genes among Pseudomonas aeruginosa: molecular characterization of MDR strains in broiler chicks and dead-in-shell chicks infections.
The study identified the presence of mcr-1 and various β-lactamase genes, including bla TEM, bla SHV, bla CTX-M, and bla OXA-10, in multidrug-resistant Pseudomonas aeruginosa isolates from broiler and dead-in-shell chicks in Egypt.
Clonal and plasmidic dissemination of critical antimicrobial resistance genes through clinically relevant ExPEC and APEC-like lineages (ST) in the dairy cattle population of Québec, Canada.
The study identifies the dissemination of critical AMR genes, including bla CTX-M-15, qnrS1, and bla TEM-1, in E. coli isolates from dairy cattle in Quebec, highlighting the persistence of these genes through plasmids and clones despite reduced antimicrobial use.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada.
The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.
Gut colonization and subsequent infection of neonates caused by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae.
The study identified the prevalence of ESBL-PEco and ESBL-PKpn in neonatal patients, with bla CTX-M-1 group, bla TEM, bla OXA-1, and bla SHV being the most common genes. These genes conferred resistance to various cephalosporins.
Klebsiella pneumoniae ST147 harboring bla(NDM-1), multidrug resistance and hypervirulence plasmids.
The study identifies the blaNDM-1 gene and various other resistance genes in multidrug-resistant Klebsiella pneumoniae ST147 strains, highlighting their role in carbapenem resistance and hypervirulence.
Klebsiella pneumoniae ST147 harboring bla(NDM-1), multidrug resistance and hypervirulence plasmids.
The study identifies the blaNDM-1 gene and various other resistance genes in multidrug-resistant Klebsiella pneumoniae ST147 strains, highlighting their role in carbapenem resistance and hypervirulence.
Anthropogenic contamination sources drive differences in antimicrobial-resistant Escherichia coli in three urban lakes.
The study identified various AMR genes and mutations in E. coli isolates from three urban lakes, highlighting the impact of anthropogenic contamination on AMR patterns. Key findings include the presence of bla CTX-M, bla TEM, bla CMY, aac(6')-Ib-cr, and mutations in gyrA and parC conferring resistance to multiple antibiotics.
Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing.
The paper discusses the prevalence of antimicrobial resistance in Aeromonas species, highlighting the presence of various beta-lactamase genes such as blaTEM-24, blaIMP-19, blaVIM-4, blaKPC-2, blaNDM-1, blaVIM-2, blaOXA-48, blaIMP-13, blaGES-5, blaTEM-1, blaSHV-12, blaVEB-9, blaMOX, blaFOX, blaACC, and others. It also identifies genes like cphA, vat, mcr-3.41, mcr-7.1, sul, dfr, tetA, rsmA, and adeF associated with resistance to sulfonamides, trimethoprim, tetracycline, polymyxin, and other antibiotics. The study emphasizes the role of horizontal gene transfer and mobile genetic elements in the dissemination of these resistance genes.
Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing.
The paper discusses the prevalence of antimicrobial resistance in Aeromonas species, highlighting the presence of various beta-lactamase genes such as blaTEM-24, blaIMP-19, blaVIM-4, blaKPC-2, blaNDM-1, blaVIM-2, blaOXA-48, blaIMP-13, blaGES-5, blaTEM-1, blaSHV-12, blaVEB-9, blaMOX, blaFOX, blaACC, and others. It also identifies genes like cphA, vat, mcr-3.41, mcr-7.1, sul, dfr, tetA, rsmA, and adeF associated with resistance to sulfonamides, trimethoprim, tetracycline, polymyxin, and other antibiotics. The study emphasizes the role of horizontal gene transfer and mobile genetic elements in the dissemination of these resistance genes.
Relationship between antimicrobial resistance and virulence factors in uropathogenic Escherichia coli isolates from Ramadi, Iraq: phenotype and genotype identification.
The study identified blaTEM, aac(3)-II, sul2, fimH, and hlyA as the most prevalent genes in UPEC isolates, with strong correlations between aac(3)-II and gentamicin resistance, sul2 and trimethoprim-sulfamethoxazole resistance, and fimH with antibiotic resistance.
Antibiotic resistance and virulence profiles of Proteus mirabilis isolated from broiler chickens at abattoir in South Africa.
The study identified multiple antibiotic resistance genes in Proteus mirabilis isolates from broiler chickens, including bla CTX-M, bla TEM, qnrA, qnrD, mcr-1, catI, catII, and ampC, highlighting the presence of multidrug-resistant strains and extended-spectrum beta-lactamase-producing isolates.
Outbreak of Multidrug-resistant Acinetobacter baumannii in a Tertiary Health Center from Northwestern Nigeria.
MDR strains of A. baumannii harboring bla SHV and bla TEM genes were recovered from clinical and environmental sources during the outbreak.
Recommendation of a standardized broth microdilution method for antimicrobial susceptibility testing of Avibacterium paragallinarum and resistance monitoring.
The study identified several antimicrobial resistance genes in Avibacterium paragallinarum, including aph(6)-Id, aph(3'')-Ib, bla TEM-1B, catA2, sul2, tet(B), tet(H), and mcr-like, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, sulfonamides, tetracyclines, and polymyxins.
Phage vB_Ec_ZCEC14 to treat antibiotic-resistant Escherichia coli isolated from urinary tract infections.
The study identifies several antibiotic resistance genes in multidrug-resistant E. coli isolates, including blaTEM, blaSHV, blaCTX, and tetA, which confer resistance to amoxicillin, ceftriaxone, and tetracycline. These findings highlight the genetic basis of resistance in the isolates.
Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021.
The study identified various antimicrobial resistance genes and mutations in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain, highlighting the presence of multidrug-resistant strains and the role of plasmids in the dissemination of resistance mechanisms.
Emergence of multidrug-resistant Bacillus spp. derived from animal feed, food and human diarrhea in South-Eastern Bangladesh.
The study identifies multiple AMR genes in Bacillus spp. isolated from animal feed, food, and human diarrhea in Bangladesh, highlighting the prevalence of multidrug resistance and the need for monitoring in the agricultural and food sectors.
The plasmidome associated with Gram-negative bloodstream infections: A large-scale observational study using complete plasmid assemblies.
The study characterizes the plasmidome associated with Gram-negative bloodstream infections, revealing that most isolates carry a large plasmid from a small number of plasmid groups. These plasmids often carry multiple antibiotic resistance, virulence, and heavy metal resistance genes. The research highlights the potential for high-risk plasmid backbones to acquire and spread ARGs, emphasizing the need for broader surveillance strategies beyond traditional AMR-focused studies.
CTX-M, TEM, and SHV Genes in Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp Isolated from Hematologic Cancer Patients with Bacteremia in Uganda.
The study identified bla CTX-M, bla TEM, and bla SHV as the most prevalent ESBL-encoding genes in Enterobacteriaceae causing bacteremia in hematologic cancer patients in Uganda. bla CTX-M was the most common, followed by bla TEM and then bla SHV.
Genetic Diversity of Salmonella enterica subsp. enterica Serovar Enteritidis from Human and Non-Human Sources in Portugal.
The study identified several AMR genes and mutations in Salmonella enterica subsp. enterica serovar Enteritidis isolates from human and non-human sources in Portugal, including blaTEM-1A, blaTEM-1B, blaCMY-2, aac(6')-Iaa, sul1, and aaDA1, as well as mutations in gyrA associated with fluoroquinolone resistance.
Genetic Diversity of Salmonella enterica subsp. enterica Serovar Enteritidis from Human and Non-Human Sources in Portugal.
The study identified several AMR genes and mutations in Salmonella enterica subsp. enterica serovar Enteritidis isolates from human and non-human sources in Portugal, including blaTEM-1A, blaTEM-1B, blaCMY-2, aac(6')-Iaa, sul1, and aaDA1, as well as mutations in gyrA associated with fluoroquinolone resistance.
Comparison of the Antibiotic Resistance of Escherichia coli Populations from Water and Biofilm in River Environments.
The study identified several beta-lactamase genes, including bla CTX-M-15, bla CTX-M-1, bla CTX-M-14, bla SHV-12, bla TEM-1, and bla KPC-2, which confer resistance to various antibiotics in E. coli isolates from river environments.
Typhoidal salmonella disease in Mukuru informal settlement, Nairobi Kenya; carriage, diversity, and antimicrobial resistant genes.
The study identified the bla TEM-1B gene in 95% of multidrug-resistant (MDR) Salmonella Typhi isolates, indicating its significant role in resistance to ampicillin.
Correlation between antimicrobial resistance, biofilm formation, and virulence determinants in uropathogenic Escherichia coli from Egyptian hospital.
The study identified bla TEM, bla SHV, and bla CTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) production in UPEC isolates from Tanta, Egypt. These genes were associated with resistance to multiple antibiotics, including cephalosporins and penicillins.
Characterization of resistance genes and replicon typing in Carbapenem-resistant Klebsiella pneumoniae strains.
The study identified several beta-lactamase genes, including bla OXA-48, bla SHV, bla TEM, bla CTX-M1, bla CTX-M2, bla IMP, and bla NDM, which contribute to carbapenem resistance in Klebsiella pneumoniae strains. The most prevalent gene was bla OXA-48, found in 96.6% of isolates.
Prevalence of multidrug-resistant and extended-spectrum β-lactamase producing Escherichia coli from local and broiler chickens at Cibinong market, West Java, Indonesia.
The study identified the presence of multidrug-resistant and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli from local and broiler chickens at Cibinong market, West Java, Indonesia. The ESBL genes bla TEM and bla CTX-M were detected in four multidrug-resistant E. coli isolates.
Antibiotic resistance and virulence genes profile of Non typhodial Salmonella species isolated from poultry enteritis in India.
The study identified several antibiotic resistance genes including blaTEM, blaSHV, blaCTX-M, tet(A), tet(B), tet(C), sul1, sul2, and sul3 in multidrug-resistant Salmonella isolates from poultry enteritis in India.
Unveiling distinct genetic features in multidrug-resistant Escherichia coli isolated from mammary tissue and gut of mastitis induced mice.
The study identified multiple antimicrobial resistance genes in multidrug-resistant E. coli strains isolated from mastitis-induced mice, highlighting the complex resistome and potential for horizontal gene transfer.
Unveiling distinct genetic features in multidrug-resistant Escherichia coli isolated from mammary tissue and gut of mastitis induced mice.
The study identified multiple antimicrobial resistance genes in multidrug-resistant E. coli strains isolated from mastitis-induced mice, highlighting the complex resistome and potential for horizontal gene transfer.
Antibiogram and molecular characterization of extended-spectrum β-lactamase-producing pathogens implicated in chronic suppurative otitis media.
The study identified blaSHV, blaTEM, and blaCTX-M as the most prevalent ESBL genes in ESBL-producing GNB pathogens isolated from CSOM patients, highlighting the emergence of multidrug-resistant strains.
Isolation, Identification, Antimicrobial Resistance, Genotyping, and Whole-Genome Sequencing Analysis of Salmonella Enteritidis Isolated from a Food-Poisoning Incident.
The study identified multiple antimicrobial resistance genes in Salmonella Enteritidis strain 21A, including aac(6')-Iaa, blaTEM-1, qnrB, floR, tetA, sul1, and sul2, which conferred resistance to various antibiotics such as aminoglycosides, beta-lactams, quinolones, tetracyclines, and sulfonamides.
Whole-genome sequencing-based antimicrobial resistance and shedding dynamics of Escherichia coli isolated from calves before and after antimicrobial group treatments.
The study identified several AMR genes and mutations in E. coli isolates from calves, including tetracycline resistance genes (Tet(A), Tet(B), Tet(C), Tet(M)), beta-lactamases (TEM-1, TEM-35, OXA-1), florfenicol resistance gene FloR, and macrolide phosphotransferase Mph(B). Mutations in GyrA (D87N, D87Y, S83L) and ParC (S80I) were also associated with quinolone resistance.
Whole-genome sequencing-based antimicrobial resistance and shedding dynamics of Escherichia coli isolated from calves before and after antimicrobial group treatments.
The study identified several AMR genes and mutations in E. coli isolates from calves, including tetracycline resistance genes (Tet(A), Tet(B), Tet(C), Tet(M)), beta-lactamases (TEM-1, TEM-35, OXA-1), florfenicol resistance gene FloR, and macrolide phosphotransferase Mph(B). Mutations in GyrA (D87N, D87Y, S83L) and ParC (S80I) were also associated with quinolone resistance.
Occurrence and molecular characteristics of antimicrobial resistance, virulence factors, and extended-spectrum beta-lactamase (ESBL) producing Salmonella enterica and Escherichia coli isolated from the retail produce commodities in Bangkok, Thailand.
The study identified several AMR genes and mutations in Salmonella enterica and Escherichia coli isolated from retail produce in Bangkok, Thailand. Key findings include the presence of bla TEM, qnrS, tetA, tetB, strA, and strB genes, as well as gyrA and parC mutations associated with ciprofloxacin resistance.
Occurrence and molecular characteristics of antimicrobial resistance, virulence factors, and extended-spectrum β-lactamase (ESBL) producing Salmonella enterica and Escherichia coli isolated from the retail produce commodities in Bangkok, Thailand.
The study identified several AMR genes and mutations in Salmonella enterica and Escherichia coli isolated from retail produce in Bangkok, Thailand. Key findings include the presence of bla TEM, qnrS, tetA, tetB, strA, and strB genes, as well as gyrA and parC mutations associated with ciprofloxacin resistance.
Plasmid-free cheater cells commonly evolve during laboratory growth.
The study identifies that plasmid-free cheater cells can evolve during laboratory growth, particularly when using plasmid-encoded beta-lactamases like bla TEM, leading to reduced plasmid maintenance and the emergence of plasmid-free cells that exploit the resistance provided by cooperative cells.
Gut diversity and the resistome as biomarkers of febrile neutropenia outcome in paediatric oncology patients undergoing hematopoietic stem cell transplantation.
The study identifies several antibiotic-resistance genes associated with febrile neutropenia in pediatric oncology patients undergoing hematopoietic stem cell transplantation, including msr(C), dfrG, erm(T), VanHAX, aac(6')-Ib, aph(3')-III, ant(6)-Ia, and aac(6')-Ii.
Gut diversity and the resistome as biomarkers of febrile neutropenia outcome in paediatric oncology patients undergoing hematopoietic stem cell transplantation.
The study identifies several antibiotic-resistance genes associated with febrile neutropenia in pediatric oncology patients undergoing hematopoietic stem cell transplantation, including msr(C), dfrG, erm(T), VanHAX, aac(6')-Ib, aph(3')-III, ant(6)-Ia, and aac(6')-Ii.
Genome mining of Escherichia coli WG5D from drinking water source: unraveling antibiotic resistance genes, virulence factors, and pathogenicity.
The study identifies multiple antibiotic resistance genes in E. coli WG5D, including multidrug efflux pumps and genes conferring resistance to various antibiotics such as fluoroquinolones, cephalosporins, and glycopeptides.
Prevalence and molecular characterization of multi-resistant Escherichia coli isolates from clinical bovine mastitis in China.
The study identified multiple AMR genes and mutations in E. coli isolates from bovine mastitis, including blaTEM, blaCTX, dfrA1, dfrA1-aadA1, dfrA1-catB2-aadA1, dfrA17-aadA5, aadA1, aadA5, catB2, catB3, and mutations in gyrA, parC, gyrB, and parE associated with fluoroquinolone resistance.
Genomic characterization of extended-spectrum beta-lactamase-producing and carbapenem-resistant Escherichia coli from urban wastewater in Australia.
The study identifies multiple AMR genes and mutations in carbapenem-resistant and ESBL-producing E. coli isolates from Australian wastewater, highlighting the presence of resistance mechanisms such as bla NDM-5, bla CMY-42, and mutations in gyrA, parC, and parE.
Antimicrobial Resistance and Molecular Characterization of Salmonella Rissen Isolated in China During 2008-2019.
The study identified multiple AMR genes in Salmonella Rissen isolates from China, including blaTEM, sul2, sul3, tetA, strA, strB, aadA, intl1VR(cx), and qacED1, which contribute to resistance against various antibiotics such as ampicillin, trimethoprim-sulfamethoxazole, tetracycline, and streptomycin.
Plasmid-mediated phenotypic noise leads to transient antibiotic resistance in bacteria.
The study identifies blaTEM-1 as a gene that contributes to transient antibiotic resistance via plasmid copy number variability, demonstrating that plasmid-mediated phenotypic noise enhances bacterial survival under antibiotic stress.
Target enrichment improves culture-independent detection of Neisseria gonorrhoeae and antimicrobial resistance determinants direct from clinical samples with Nanopore sequencing.
The study shows that target enrichment improves the detection of Neisseria gonorrhoeae and antimicrobial resistance determinants in clinical samples using Nanopore sequencing. It identifies blaTEM-1 as a beta-lactamase gene and detects gyrA mutations (S91F, D95G) associated with quinolone resistance.
Detection of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacteriaceae from Diseased Broiler Chickens in Lusaka District, Zambia.
The study identified bla CTX-M and bla TEM genes in ESBL-producing Enterobacteriaceae from diseased broiler chickens in Lusaka, Zambia, indicating the presence of multidrug-resistant bacteria.
Multilocus sequence typing and antibiotic resistance of Aeromonas isolated from freshwater fish in Hebei Province.
The study identified several AMR genes in Aeromonas isolates from freshwater fish in Hebei Province, including TEM, tetA, floR, sul2, Ant(3")-I, and qacEΔ1, which confer resistance to various antibiotics such as penicillin, tetracycline, chloramphenicol, sulfonamide, aminoglycoside, and quinolone.
Horizontal transfer characterization of ColV plasmids in bla(CTX-M)-bearing avian Escherichia coli.
The study characterizes the horizontal transfer of ColV plasmids in bla(CTX-M)-bearing avian E. coli, identifying multiple resistance genes and virulence factors associated with these plasmids.
Activity of Epsilon-poly-L-lysine against Multidrug-Resistant Pseudomonas aeruginosa and Klebsiella pneumoniae Isolates of Urinary Tract Infections.
The study identified various beta-lactamase genes, including blaSPM, blaKPC, blaSHV, blaCTX-M, blaOXA, blaTEM, blaPER, blaVIM, and blaVIM-2 in Pseudomonas aeruginosa, and blaCTX-M, blaTEM, blaKPC, blaNDM, and blaOXA in Klebsiella pneumoniae. Additionally, aac(3)-IV, aadA1, aac(3)-II, sul2, sul1, sul3, dfrA, cmlA, and tetA were found to confer resistance to aminoglycosides, sulfonamides, trimethoprim, chloramphenicol, and tetracyclines.
Wounds of Companion Animals as a Habitat of Antibiotic-Resistant Bacteria That Are Potentially Harmful to Humans-Phenotypic, Proteomic and Molecular Detection.
The study identified several antibiotic resistance genes, including strA (streptomycin resistance), sul3 (sulfonamide resistance), and blaTEM (extended-spectrum beta-lactamase), in bacterial isolates from companion animal wounds. These genes were detected using PCR and were associated with resistance to specific antibiotics.
Prevalence and antimicrobial resistance profiles of mastitis causing bacteria isolated from dairy goats in Mukurweini Sub-County, Nyeri County, Kenya.
The study identified the presence of mecA gene in Staphylococcus aureus isolates, indicating methicillin resistance, and blaTEM gene in Escherichia coli, Enterobacter spp., and Klebsiella oxytoca isolates, indicating beta-lactam resistance.
Molecular detection of extended-spectrum beta-lactamase-producing Escherichia coli from bat caves on Lombok Island.
The study identified the blaTEM gene in multidrug-resistant Escherichia coli isolates from bat fecal samples, indicating the potential for bats to spread ESBL resistance genes to the environment and humans.
Molecular characterization of Aeromonas hydrophila detected in Channa marulius and Sperata sarwari sampled from rivers of Punjab in Pakistan.
The study identified several AMR genes in Aeromonas hydrophila isolates from fish samples, including tetA, blaTEM, qnrA, qnrB, sul1, and sul3, indicating multidrug resistance.
Comparison of genotypic and phenotypic antimicrobial resistance profiles of Salmonella enterica isolates from poultry diagnostic specimens.
The study identified 31 AMR genes in 97 Salmonella enterica isolates from poultry, including aac(3)-IId, aac(3)-IVa, aac(3)-VIa, aac(6′)-Ib4, ant(2′′)-Ia, grdA, aph(3′)-Ia, aph(3′)-IIa, aadA1, aadA2, aadA7, aadA13, aph(3′)-Ib, aph(6)-Ic, aph(6)-Id, aph(4)-Ia, blaCMY-2, blaCTX-M-1, blaHER-3, blaTEM-1, floR, tetA, tetB, tetC, dfrA12, sul1, sul2, fosA7, qnrB19, ble, and mcr-9.
Extended-spectrum beta-lactamases in clinical isolates of Escherichia coli and Klebsiella pneumoniae recovered from patients at the Tamale Teaching Hospital, Ghana.
The study identified bla TEM, bla CTX-M-1, and bla SHV genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) resistance in E. coli and K. pneumoniae isolates from the Tamale Teaching Hospital in Ghana.
Antimicrobial resistance of avian pathogenic Escherichia coli isolated from broiler, layer, and breeder chickens.
The study identified multiple antibiotic resistance genes in avian pathogenic Escherichia coli (APEC) isolates from commercial chickens in Nepal, including blaTEM, sul1, qnrA, tetB, cat1, ereA, mcr1, and aac(3)-IV, which confer resistance to various antimicrobial agents.
Klebsiella pneumoniae exhibiting a phenotypic hyper-splitting phenomenon including the formation of small colony variants.
The study identifies multiple beta-lactamase genes, including bla SHV-11, bla OXA-1, bla OXA-9, bla OXA-48, bla TEM-1D, bla CTX-M-15, and bla NDM-1, as well as sul1 and catB3, which confer resistance to various antibiotics in Klebsiella pneumoniae isolates from a patient with a complex infection history.
Rapid detection and molecular epidemiology of beta-lactamase producing Enterobacteriaceae isolated from food animals and in-contact humans in Nigeria.
The study developed and validated a multiplex qPCR assay for detecting beta-lactamase genes (bla CTX-M, bla TEM, and bla SHV) in Enterobacteriaceae isolated from food animals and in-contact humans in Nigeria. The assay showed 100% sensitivity and specificity. The prevalence of bla TEM and bla SHV varied among different species and sampling locations, with Klebsiella pneumoniae showing the highest prevalence of these genes.
A sophisticated virulence repertoire and colistin resistance of Citrobacter freundii ST150 from a patient with sepsis admitted to ICU in a tertiary care hospital in Uganda, East Africa: Insight from genomic and molecular docking analyses.
Citrobacter freundii strain RSM030 was found to possess chromosomal beta-lactam resistance genes (blaCMY-79, blaCMY-116, blaTEM-1B) and polymyxin resistance genes (arnD, arnT, eptA, eptB) that confer resistance to multiple antibiotics, including colistin. Additionally, mutations in PmrA/PmrB, mgrB, and PhoP/PhoQ were associated with colistin resistance.
Detection of Extended Spectrum ß-Lactamase-Producing Escherichia coli with Biofilm Formation from Chicken Meat in Istanbul.
The study identified bla TEM, bla CTX-M, bla SHV, and bla OXA genes in E. coli isolates from chicken meat in Istanbul, with bla TEM being the most prevalent. No mcr, bla NDM, bla KPC, bla VIM, or bla OXA-48 genes were detected.
Detection of Extended Spectrum ß-Lactamase-Producing Escherichia coli with Biofilm Formation from Chicken Meat in Istanbul.
The study identified bla TEM, bla CTX-M, bla SHV, and bla OXA genes in E. coli isolates from chicken meat in Istanbul, with bla TEM being the most prevalent. No mcr, bla NDM, bla KPC, bla VIM, or bla OXA-48 genes were detected.
Identification and Evaluation of Pathogenic Genes (traT, hly, aer, pap, and fimH) and Antibiotic Resistance Genes (blaTEM, blaSHV, and blaCTX) in Escherichia coli in Patients Referred to Gonabad Hospitals, Iran.
The study identified blaTEM, blaSHV, and blaCTX genes as prevalent beta-lactam resistance genes in E. coli isolates from UTI patients in Gonabad, Iran, contributing to multidrug resistance.
Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum beta-lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease.
The study characterizes three ciprofloxacin-resistant and extended-spectrum beta-lactamase (ESBL)-producing Salmonella enterica serovar Kentucky ST198 strains from a single patient with inflammatory bowel disease, highlighting their multidrug-resistant profile and potential epidemiological links to strains from chicken meat.
Klebsiella pneumoniae sequence type 147: a high-risk clone increasingly associated with plasmids carrying both resistance and virulence elements.
The study identified various AMR genes and mutations in Klebsiella pneumoniae ST147 isolates, including bla NDM-5, bla NDM-1, bla OXA-181, bla OXA-232, bla OXA-48, aadA1, aph(3')-VI, bla CTX-M-15, bla TEM-1B/C, bla OXA-9, truncated catA1, qnrS1, sul1, dfrA5, mph(A), erm(B), aac(6')-Ib, aac(6')-Ib3, sul2, aph(3')-Ia, rmtB, fosA, oqxAB, bla SHV-11/67, arr-3, and catB3.
Predominance of multidrug-resistant Salmonella Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar.
The study identifies multidrug-resistant Salmonella Typhi genotype 4.3.1.1 with low-level ciprofloxacin resistance in Zanzibar, highlighting the presence of resistance genes blaTEM-1B, sul1, sul2, dfrA7, catA1, aph(6)-Id, and aph(3")-Ib, along with gyrA mutations D87G and S83F.
Occurrence, virulence, and resistance genes in Salmonella enterica isolated from an integrated poultry company in Jordan.
The study identified blaTEM as the most prevalent antimicrobial resistance gene in Salmonella isolates from an integrated poultry company in Jordan, conferring resistance to multiple antibiotics including ampicillin, tetracycline, ciprofloxacin, nalidixic acid, doxycycline, and sulfamethoxazole-trimethoprim.
Phenotypic and genotypic characterization of extended spectrum beta-lactamase producing E. coli harboring carbapenem and colistin-resistant genes from poultry farms in Egypt.
The study identified multiple AMR genes in ESBL-producing E. coli from poultry farms in Egypt, including bla TEM-3, bla SHV-4, bla CTX-M-1, bla CTX-M-14, bla NDM-1, and mcr-1, highlighting the public health risks associated with multidrug-resistant E. coli.
High prevalence of multidrug-resistant Enterobacterales carrying extended-spectrum beta-lactamase and AmpC genes isolated from neonatal sepsis in Ahvaz, Iran.
The study identified a high prevalence of multidrug-resistant Enterobacterales carrying extended-spectrum beta-lactamase (ESBL) and AmpC genes, with bla CTX-M−15 being the most common ESBL gene.
Comparison of IncK-bla(CMY-2) Plasmids in Extended-Spectrum Cephalosporin-Resistant Escherichia coli Isolated from Poultry and Humans in Denmark, Finland, and Germany.
The study characterizes IncK-bla(CMY-2) plasmids in extended-spectrum cephalosporin-resistant E. coli isolates from poultry and humans in Denmark, Finland, and Germany, identifying multiple resistance genes including bla(CMY-2), aadA1, aac(3)-Vla, aph(3")-Ib, aph(6)-Id, aac(3)-IId, aadA5, aph(3′)-Ia, sul1, sul2, tet(A), tet(B), and bla TEM-1B.
The emergence of carbapenem-resistance and New Delhi metallo-β-lactamase-1 (bla(NDM-1)) among Salmonella spp. in Kerman, Iran.
The study reports the first occurrence of blaNDM-1 in Salmonella spp. in Kerman, Iran, highlighting the emergence of carbapenem-resistant strains. blaTEM was the most prevalent beta-lactamase gene, while blaNDM-1 was detected in 15.4% of isolates.
A novel variant in Salmonella genomic island 1 of multidrug-resistant Salmonella enterica serovar Kentucky ST198.
The study identified a novel variant of SGI1-K in multidrug-resistant Salmonella enterica serovar Kentucky ST198, including the presence of blaTEM-1b and lnu(F) genes, along with chromosomal mutations in gyrA and parC contributing to ciprofloxacin resistance.
Tracking antimicrobial resistance transmission in urban and rural communities in Bangladesh: a One Health study of genomic diversity of ESBL-producing and carbapenem-resistant Escherichia coli.
The study identified various beta-lactamase genes, including bla CTX-M-15, bla TEM-1b, bla OXA-1, and carbapenem resistance genes like bla NDM-5, bla NDM-7, and bla NDM-1, in ESBL-producing and carbapenem-resistant E. coli isolates from Bangladesh.
Assessment of three antibiotic combination regimens against Gram-negative bacteria causing neonatal sepsis in low- and middle-income countries.
The study identifies multiple AMR genes and mutations in Gram-negative bacteria causing neonatal sepsis in LMICs, including ESBLs, carbapenemases, and aminoglycoside-modifying enzymes, highlighting the high prevalence of multidrug resistance and the need for effective antibiotic combinations.
Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance.
The study identifies three mechanisms (tandem amplification, increased plasmid copy number, and transposition of resistance genes) that generate gene copy number variation and transient antibiotic heteroresistance in Klebsiella pneumoniae and Escherichia coli.
Antimicrobial resistance and population genomics of emerging multidrug-resistant Salmonella 4,[5],12:i:- in Guangdong, China.
The study identified multiple AMR genes and mutations in Salmonella 4,[5],12:i:- isolates from Guangdong, China, including gyrA mutations, PMQR genes, and various beta-lactamase genes, contributing to multidrug resistance.
Low-frequency transmission and persistence of antimicrobial-resistant bacteria and genes from livestock to agricultural soil and crops through compost application.
The study identified bla CTX-M-2 and bla TEM genes in beta-lactam-resistant Escherichia coli and Escherichia fergusonii isolated from cattle feces, liquid compost, and soil, indicating the transmission of antimicrobial-resistant bacteria and genes from livestock to agricultural soils through compost application.
Synanthropic rodents and shrews are reservoirs of zoonotic bacterial pathogens and act as sentinels for antimicrobial resistance spillover in the environment: A study from Puducherry, India.
The study identified various AMR genes in bacterial isolates from synanthropic rodents and shrews, including mecA, mecC, blaTEM, blaSHV, blaCTX-M, tet, sul3, sul4, and qnrA, indicating their role as reservoirs of AMR pathogens.
Prevalence and Antimicrobial Resistance Diversity of Salmonella Isolates in Jiaxing City, China.
The study identified several AMR genes and mutations in Salmonella isolates from Jiaxing City, China, including blaTEM-1B, blaOXA-10, blaCTX-M-65, floR, sul2, qnrS1, and tet(B), as well as mutations in gyrA and parC contributing to fluoroquinolone resistance.
Rumi and Pasteurized Kareish Cheeses Are a Source of β-Lactam-Resistant Salmonella in the Nile Delta Region of Egypt: Insights into Their Incidence, AMR Pattern, Genotypic Determinants of Virulence and β-Lactam Resistance.
The study identifies several β-lactam resistance genes, including bla OXA-1, bla OXA-2, bla TEM-1, bla CTX-M, bla CMY-1, and bla CMY-2, in β-lactam-resistant Salmonella isolates from Rumi and pasteurized Kareish cheeses in the Nile Delta region of Egypt.
Detection of Salmonella Pathogenicity Islands and Antimicrobial-Resistant Genes in Salmonella enterica Serovars Enteritidis and Typhimurium Isolated from Broiler Chickens.
The study identified several antimicrobial-resistant genes in Salmonella enterica serovars Enteritidis and Typhimurium isolated from broiler chickens, including tet(K), tet(O), tet(A), mcr-1, mcr-4, strA, strB, aadA, aadE, sulI, ampC, TEM, CTX-M, and OXA. These genes conferred resistance to tetracycline, colistin, aminoglycosides, sulfonamides, and beta-lactam antibiotics.
Molecular basis of the persistence of chloramphenicol resistance among Escherichia coli and Salmonella spp. from pigs, pork and humans in Thailand.
The study identifies catA and cmlA as the primary genes responsible for chloramphenicol resistance in E. coli and Salmonella isolates from Thailand, highlighting their persistence through co-selection and horizontal gene transfer.
Genomic analysis of multidrug-resistant Escherichia coli from Urban Environmental water sources in Accra, Ghana, Provides Insights into public health implications.
The study identified several AMR genes in multidrug-resistant E. coli isolates from urban environmental water sources in Accra, Ghana, highlighting the presence of beta-lactamases (blaTEM-1B, blaCTX-M-15, blaTEM-1C, blaDHA-1, blaOXA-1, blaOXA-181), sulfonamide resistance genes (sul2, sul1), aminoglycoside resistance genes (aph(6)-Id, aadA2, mph(A)), quinolone resistance gene (qnrS1), tetracycline resistance gene (tet(B)), chloramphenicol resistance gene (catA1), dihydrofolate reductase (dfrA14), and others.
Genomic analysis of multidrug-resistant Escherichia coli from Urban Environmental water sources in Accra, Ghana, Provides Insights into public health implications.
The study identified several AMR genes in multidrug-resistant E. coli isolates from urban environmental water sources in Accra, Ghana, highlighting the presence of beta-lactamases (blaTEM-1B, blaCTX-M-15, blaTEM-1C, blaDHA-1, blaOXA-1, blaOXA-181), sulfonamide resistance genes (sul2, sul1), aminoglycoside resistance genes (aph(6)-Id, aadA2, mph(A)), quinolone resistance gene (qnrS1), tetracycline resistance gene (tet(B)), chloramphenicol resistance gene (catA1), dihydrofolate reductase (dfrA14), and others.
Genomic analysis of multidrug-resistant Escherichia coli from Urban Environmental water sources in Accra, Ghana, Provides Insights into public health implications.
The study identified several AMR genes in multidrug-resistant E. coli isolates from urban environmental water sources in Accra, Ghana, highlighting the presence of beta-lactamases (blaTEM-1B, blaCTX-M-15, blaTEM-1C, blaDHA-1, blaOXA-1, blaOXA-181), sulfonamide resistance genes (sul2, sul1), aminoglycoside resistance genes (aph(6)-Id, aadA2, mph(A)), quinolone resistance gene (qnrS1), tetracycline resistance gene (tet(B)), chloramphenicol resistance gene (catA1), dihydrofolate reductase (dfrA14), and others.
Genomic analysis of multidrug-resistant Escherichia coli from Urban Environmental water sources in Accra, Ghana, Provides Insights into public health implications.
The study identified several AMR genes in multidrug-resistant E. coli isolates from urban environmental water sources in Accra, Ghana, highlighting the presence of beta-lactamases (blaTEM-1B, blaCTX-M-15, blaTEM-1C, blaDHA-1, blaOXA-1, blaOXA-181), sulfonamide resistance genes (sul2, sul1), aminoglycoside resistance genes (aph(6)-Id, aadA2, mph(A)), quinolone resistance gene (qnrS1), tetracycline resistance gene (tet(B)), chloramphenicol resistance gene (catA1), dihydrofolate reductase (dfrA14), and others.
Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: insights from a tertiary hospital in Southern Thailand.
The study identified bla TEM, bla CTX-M, and bla SHV genes as the primary resistance mechanisms in ESBL-producing E. coli and K. pneumoniae isolates in Southern Thailand.
Occurrence, molecular characterization, and antimicrobial susceptibility of sorbitol non-fermenting Escherichia coli in lake water, fish and humans in central Oromia, Ethiopia.
The study identified multiple antimicrobial resistance genes in sorbitol non-fermenting E. coli strains, including blaTEM-1B, tet(A), dfrA1, dfrA5, sul1, fos7, catA1, qnrS1, gyrA, and blaCTX-M15, which conferred resistance to various antibiotics such as ampicillin, tetracycline, trimethoprim, sulfamethoxazole, fosfomycin, chloramphenicol, ciprofloxacin, nalidixic acid, and extended-spectrum beta-lactams.
Widespread prevalence of plasmid-mediated blaCTX-M type extended-spectrum beta-lactamase Escherichia coli in backyard broiler production systems in the United States.
The study identified blaCTX-M type extended-spectrum beta-lactamase (ESBL) Escherichia coli in backyard broiler production systems in the United States, with a higher prevalence in backyard farms compared to commercial farms. The most common blaCTX-M variants were blaCTX-M-1, blaCTX-M-55, and blaCTX-M-65. Resistance to cefepime, a fourth-generation cephalosporin, was also observed.
Evolutionary druggability for low-dimensional fitness landscapes toward new metrics for antimicrobial applications.
The study characterizes mutations in TEM-1 and TEM-50 β-lactamases that affect variant vulnerability and drug applicability, highlighting the impact of specific amino acid changes on resistance to β-lactam antibiotics.
Evolutionary druggability for low-dimensional fitness landscapes toward new metrics for antimicrobial applications.
The study characterizes mutations in TEM-1 and TEM-50 β-lactamases that affect variant vulnerability and drug applicability, highlighting the impact of specific amino acid changes on resistance to β-lactam antibiotics.
Occurrence and genomic characterization of antimicrobial-resistant and potential pathogenic Escherichia coli from Italian artisanal food productions of animal origin.
The study identified multiple antimicrobial resistance (AMR) genes in Escherichia coli isolates from Italian artisanal food products, including beta-lactamases, aminoglycoside-modifying enzymes, trimethoprim resistance genes, macrolide resistance genes, quinolone resistance proteins, sulfonamide resistance proteins, and tetracycline resistance genes. These genes were primarily carried on plasmids and contributed to multidrug resistance.
Genomic characterisation of Escherichia coli isolated from poultry at retail through Sink Surveillance in Dhaka, Bangladesh reveals high levels of multi-drug resistance.
The study identified multiple AMR genes in E. coli isolates from poultry in Bangladesh, including genes conferring resistance to various antibiotics such as tetracycline, ciprofloxacin, azithromycin, colistin, and others. High levels of multidrug resistance were observed, with specific genes like mcr1.1, bla CTX-M-65, and tet(A) playing significant roles.
Virulent-MDR-ESBL E. coli and Klebsiella pneumoniae report from North Sinai calves diarrhea and in vitro antimicrobial by Moringa oleifera.
The study identified blaTEM, blaSHV, and blaCTX-M9 genes in E. coli and K. pneumoniae isolates, along with the gyrA gene in K. pneumoniae, which contribute to multidrug resistance and extended-spectrum beta-lactamase (ESBL) production.
Salmonella Typhi Haplotype 58 (H58) Biofilm Formation and Genetic Variation in Typhoid Fever Patients with Gallstones in an Endemic Setting in Kenya.
The study identified multidrug resistance genes such as sul1, dfrA7, catA1, aph(6)-Id, aph(3")-Ib, sul2, and blaTEM-1 in S. Typhi isolates from patients with gallstones. Additionally, point mutations in the quinolone resistance determining region (QRDR) of gyrA (S83Y) and gyrB (S464F) were observed, contributing to resistance against ciprofloxacin and nalidixic acid.
The Rising Tide of Antibiotic Resistance: A Study on Extended-Spectrum Beta-Lactamase and Carbapenem-Resistant Escherichia coli and Klebsiella pneumoniae.
The study identifies the presence of extended-spectrum beta-lactamase (ESBL)-producing and carbapenem-resistant Enterobacterales, specifically Escherichia coli and Klebsiella pneumoniae, in clinical settings in Pakistan. Key resistance genes include bla CTX-M, bla TEM, bla SHV, bla NDM, bla VIM, and bla IMP.
The novel 2024 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations and superseded WHO N. gonorrhoeae reference strains-phenotypic, genetic and reference genome characterization.
The 2024 WHO Neisseria gonorrhoeae reference strains were characterized for their antimicrobial resistance profiles, including mutations in genes such as GyrA, ParC, 23S rRNA, rpsJ, penA, mtrR, and mtrD, as well as the presence of beta-lactamase genes like blaTEM-1 and blaTEM-135, and tetracycline resistance gene tet(M).
The novel 2024 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations and superseded WHO N. gonorrhoeae reference strains-phenotypic, genetic and reference genome characterization.
The 2024 WHO Neisseria gonorrhoeae reference strains were characterized for their antimicrobial resistance profiles, including mutations in genes such as GyrA, ParC, 23S rRNA, rpsJ, penA, mtrR, and mtrD, as well as the presence of beta-lactamase genes like blaTEM-1 and blaTEM-135, and tetracycline resistance gene tet(M).
Costs of antibiotic resistance genes depend on host strain and environment and can influence community composition.
The study identifies that certain antibiotic resistance genes (ARGs) such as bla TEM-116 *, cat, and dfrA5 impose fitness costs in various Escherichia spp. strains, highlighting the variability of these effects across different host backgrounds.
Costs of antibiotic resistance genes depend on host strain and environment and can influence community composition.
The study identifies that certain antibiotic resistance genes (ARGs) such as bla TEM-116 *, cat, and dfrA5 impose fitness costs in various Escherichia spp. strains, highlighting the variability of these effects across different host backgrounds.
Computational Design of beta-lactamases with Enhanced Stability and Activity
The study demonstrates that computationally designed variants of TEM-1 beta-lactamase can maintain functionality and confer resistance to ampicillin despite numerous mutations.
Efficacy and Mechanism of Antibiotic Resistance Gene Degradation and Cell Membrane Damage during Ultraviolet Advanced Oxidation Processes.
The study investigated the degradation of the ampicillin resistance gene blaTEM-1 under different UV-AOPs and found that UV/chlorine was the most effective in degrading the gene, followed by UV/H2O2 and UV/PAA. The study also showed that free chlorine caused significant membrane damage, leading to the release of intracellular ARGs.
Four novel Acinetobacter lwoffii strains isolated from the milk of cows in China with subclinical mastitis.
Four Acinetobacter lwoffii strains were isolated from the milk of cows with subclinical mastitis in China. These strains exhibited multidrug resistance and carried 17 resistance genes, including beta-lactamase, aminoglycoside-modifying, fluoroquinolone, tetracycline, sulfonamide, and chloramphenicol resistance genes.
Antibiotic Resistance Profile and Bio-Control of Multidrug-Resistant Escherichia coli Isolated from Raw Milk in Vietnam Using Bacteriophages.
The study identified multidrug-resistant E. coli strains in raw milk in Vietnam carrying bla TEM, bla CTX-M-1, and mcr-1 genes, which confer resistance to beta-lactams and colistin. Phage PEM3 effectively reduced the viable counts of these multidrug-resistant strains.
Whole-Genome Analysis of Extensively Drug-Resistant Enterobacter hormaechei Isolated from a Patient with Non-Hodgkin's Lymphoma.
The study identifies an extensively drug-resistant Enterobacter hormaechei ST90 clone carrying multiple resistance genes, including bla CTX-M-15, bla GES-2, bla TEM-1A, bla OXA-1, bla NDM-1, and bla ACT-15, along with genes encoding resistance to aminoglycosides, quinolones, sulfonamides, chloramphenicol, fosfomycin, and other antibiotics.
The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi.
The study identifies multiple antimicrobial resistance (AMR) genes and mutations in Salmonella Typhi H58 lineage, highlighting its multidrug resistance and the role of IncH1 plasmids in conferring resistance to various antibiotics.
Colistin-, cefepime-, and levofloxacin-resistant Salmonella enterica serovars isolated from Egyptian chicken carcasses.
The study identified beta-lactamase resistance genes bla TEM, bla CTX-M1, and bla OXA in cefotaxime-resistant Salmonella isolates from Egyptian chicken carcasses, contributing to multidrug resistance.
Correlation analysis of whole genome sequencing of a pathogenic Escherichia coli strain of Inner Mongolian origin.
The study identified 127 antibiotic resistance genes in the E. coli strain E12, including genes for beta-lactamases, aminoglycoside modifying enzymes, sulfonamide resistance, and efflux pumps, indicating a high level of multidrug resistance.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
The IncC and IncX1 resistance plasmids present in multi-drug resistant Escherichia coli strains isolated from poultry manure in Poland.
The study identifies three resistance plasmids (pECmdr13.2, pECmdr13.3, pECmdr14.1) in multi-drug resistant E. coli strains from poultry manure in Poland, each carrying various AMR genes including tetracycline, aminoglycoside, beta-lactam, sulfonamide, fluoroquinolone, and phenicol resistance genes.
The Prevalence of Multidrug-Resistant Escherichia coli in Chennai and Whole Genome Sequence Analysis of Carbapenem-Resistant Escherichia coli ST410.
The study identifies multiple antimicrobial resistance genes and mutations in a carbapenem-resistant Escherichia coli ST410 isolate, including blaTEM-1B, blaCTX-M-15, blaNDM-5, armA, aac(3)-IId, and gyrA mutations (p.S83L and p.D87N), which confer resistance to beta-lactams, cephalosporins, carbapenems, aminoglycosides, and fluoroquinolones.
Study of the Genomic Characterization of Antibiotic-Resistant Escherichia Coli Isolated From Iraqi Patients with Urinary Tract Infections.
The study identified the presence of blaTEM, blaSHV, and blaCTXM genes in E. coli isolates from Iraqi patients with urinary tract infections, contributing to resistance against beta-lactam antibiotics.
A newly identified IncY plasmid from multi-drug-resistant Escherichia coli isolated from dairy cattle feces in Poland.
The study identifies two IncY plasmids from multi-drug-resistant E. coli isolated from dairy cattle feces in Poland, carrying resistance genes against beta-lactams, aminoglycosides, tetracyclines, trimethoprim/sulfamethoxazole, and fluoroquinolones.
Salmonella Typhi genotypic diversity, cluster identification and antimicrobial resistance determinants in Mukuru settlement, Nairobi Kenya.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella Typhi isolates from Mukuru settlement, Nairobi, Kenya, highlighting the prevalence of multidrug-resistant strains.
Mobile genetic elements define the non-random structure of the Salmonella enterica serovar Typhi pangenome.
The study identifies multiple AMR genes, including blaTEM-1B, qnrS1, sul2, tet(A), aph(3'')-Ib, aph(6)-Id, dfrA14, blaCTX-M-15, blaCTX-M-88, catA1, qacE, sul1, and tet(B), which are associated with multidrug-resistant and extensively drug-resistant Salmonella enterica serovar Typhi strains.
Mobile genetic elements define the non-random structure of the Salmonella enterica serovar Typhi pangenome.
The study identifies multiple AMR genes, including blaTEM-1B, qnrS1, sul2, tet(A), aph(3'')-Ib, aph(6)-Id, dfrA14, blaCTX-M-15, blaCTX-M-88, catA1, qacE, sul1, and tet(B), which are associated with multidrug-resistant and extensively drug-resistant Salmonella enterica serovar Typhi strains.
Host species shapes genotype, antimicrobial resistance, and virulence profiles of enterotoxigenic Escherichia coli (ETEC) from livestock in the United States.
The study identifies distinct antimicrobial resistance (AMR) gene profiles in bovine and swine enterotoxigenic Escherichia coli (ETEC) isolates, highlighting differences in the prevalence of specific AMR genes and plasmid replicons between the two host species.
Emergence of Extensively Drug-Resistant Neisseria gonorrhoeae, France, 2023.
Multi-drug resistant (MDR) Gram-negative pathogenic bacteria isolated from poultry in the Noakhali region of Bangladesh.
The study identified multiple AMR genes, including blaTEM, blaSHV, tetA, tetB, sul1, sul2, and mcr-1, in various multidrug-resistant Gram-negative bacteria isolated from poultry in Bangladesh. These genes conferred resistance to a wide range of antibiotics, highlighting the significant public health concerns associated with AMR in poultry.
Phylogenetic group, antibiotic resistance, virulence gene, and genetic diversity of Escherichia coli causing bloodstream infections in Iran.
The study identified several AMR genes, including bla TEM, sul1, sul2, bla CTX-M, and bla OXA, in E. coli isolates causing bloodstream infections in Iran. These genes were associated with resistance to multiple antibiotics, highlighting the prevalence of multidrug-resistant strains.
Isolation and characterization of cefotaxime resistant Escherichia coli from household floors in rural Bangladesh.
The study identified bla CTX-M, bla TEM, and bla SHV genes as the primary contributors to cefotaxime resistance in E. coli isolates from household floors in rural Bangladesh. These genes were found in a high proportion of the isolates, with bla CTX-M being the most prevalent.
Antimicrobial Susceptibility and Genetic Epidemiology of Extended-Spectrum β-Lactamase-Positive Enterobacterales Clinical Isolates in Central Poland.
The study identified the prevalence of extended-spectrum beta-lactamase (ESβL) genes, including bla CTX-M, bla SHV, bla TEM, and bla VEB, in Enterobacterales clinical isolates from central Poland. The most common ESβL gene was bla CTX-M, and multiple resistance genes were often co-present in isolates.
Phenotypic and molecular characterization of multidrug-resistant Enterobacterales isolated from clinical samples in Palestine: a focus on extended-spectrum β-lactamase- and carbapenemase-producing isolates.
The study identified several AMR genes, including blaTEM, blaSHV, blaCTXm, blaNDM, blaOXA48, and blaKPC, which confer resistance to various beta-lactam antibiotics. These genes were detected in multidrug-resistant Enterobacterales isolates from clinical samples in Palestine.
Population genomics uncovers global distribution, antimicrobial resistance, and virulence genes of the opportunistic pathogen Klebsiella aerogenes.
The study characterizes various antimicrobial resistance genes in Klebsiella aerogenes, including beta-lactamases, carbapenemases, and colistin resistance genes, highlighting the diversity and global distribution of these resistance mechanisms.
The synergy effect of matrine and berberine hydrochloride on treating colibacillosis caused by an avian highly pathogenic multidrug-resistant Escherichia coli.
The study identified multiple antibiotic resistance genes in a multidrug-resistant Escherichia coli strain, including blaTEM, ermA, ermB, aadA1, qnrS, qepA, oqxA, tetA, tetB, and tetC, which conferred resistance to various antibiotics such as beta-lactams, macrolides, aminoglycosides, quinolones, and tetracyclines. The combination of matrine and berberine hydrochloride showed synergistic antibacterial effects against this strain.
Assessing the Public Health Implications of Virulent and Antibiotic-Resistant Bacteria in Côte d'Ivoire's Ready-to-Eat Salads.
The study identified antibiotic resistance genes such as blaTEM, qnrA, qnrB, qnrS, and mecA in E. coli and S. aureus isolates from ready-to-eat salads in Côte d'Ivoire, highlighting the challenge of multidrug resistance.
Solid waste dumpsite leachate and contiguous surface water contain multidrug-resistant ESBL-producing Escherichia coli carrying Extended Spectrum beta-lactamase (ESBL) genes.
The study identified bla CTX−M and bla TEM genes in multidrug-resistant ESBL-producing E. coli isolates from dumpsite leachate and surface water, highlighting the environmental spread of these resistance genes.
Resolved genomes of wastewater ESBL-producing Escherichia coli and metagenomic analysis of source wastewater samples.
The study identified several beta-lactam resistance genes, including bla CTX-M-55, bla TEM-1, and bla SHV-2A, along with aminoglycoside, tetracycline, and sulfonamide resistance genes in ESBL-producing E. coli isolates from wastewater samples.
Molecular characterization of NDM and OXA-48-like-producing Klebsiella pneumoniae ST16 and hypervirulent ST337 clone among two patients; a case report.
The study identifies carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates carrying bla NDM, bla OXA-48-like, bla CTX-M, bla TEM, and bla SHV genes, along with virulence genes iucA, rmpA2, and rmpA in a hypervirulent ST337 clone. These isolates exhibited resistance to multiple antibiotics, including meropenem and colistin.
Evolution of extended-spectrum beta-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years.
The study identifies various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-15, blaCTX-M-27, blaCTX-M-14, and others, in ST131 E. coli isolates from a single hospital over 15 years. These genes are associated with resistance to multiple β-lactam antibiotics.
Evolution of extended-spectrum beta-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years.
The study identifies various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-15, blaCTX-M-27, blaCTX-M-14, and others, in ST131 E. coli isolates from a single hospital over 15 years. These genes are associated with resistance to multiple β-lactam antibiotics.
Evolution of extended-spectrum beta-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years.
The study identifies various extended-spectrum beta-lactamase (ESBL) genes, including blaCTX-M-15, blaCTX-M-27, blaCTX-M-14, and others, in ST131 E. coli isolates from a single hospital over 15 years. These genes are associated with resistance to multiple β-lactam antibiotics.
IncC plasmid genome rearrangements influence the vertical and horizontal transmission tradeoff in Escherichia coli.
The study identifies blaCTX-M-14 and blaCTX-M-15 as beta-lactamase genes, aacC2, aph, and sul2 as aminoglycoside and sulfonamide resistance genes, and shows that plasmid rearrangements enhance conjugation efficiency without affecting vertical transmission.
Evolution of the Antibiotic Resistance Levels, Multi-Resistance Patterns, and Presence of Antibiotic Resistance Genes in E. coli Isolates from the Feces of Breeding Hens during the Rearing Period.
The study identified several antibiotic resistance genes in E. coli isolates from breeding hens, including bla TEM, bla SHV, qnr B, and bla CMY-2. These genes were associated with resistance to various antibiotics, and their prevalence varied across different stages of hen rearing.
Lippia origanoides and Thymus vulgaris Essential Oils Synergize with Ampicillin against Extended-Spectrum Beta-Lactamase-Producing Escherichia coli.
The study identifies bla TEM and bla CTX-M genes as responsible for beta-lactam resistance in ESBL-producing E. coli strains and demonstrates the synergistic effect of Lippia origanoides and Thymus vulgaris essential oils with ampicillin.
A Health Threat from Farm to Fork: Shiga Toxin-Producing Escherichia coli Co-Harboring bla(NDM-1) and mcr-1 in Various Sources of the Food Supply Chain.
The study identified the presence of bla(NDM-1) and mcr-1 genes in non-O157 Shiga toxin-producing Escherichia coli (STEC) isolates from various food sources, highlighting the spread of multidrug-resistant strains in the food supply chain.
High Carriage of tetA, sul1, sul2 and bla (TEM) Resistance Genes among the Multidrug-resistant Uropathogenic Escherichia coli (UPEC) Strains from Malaysian Patients.
The study identified the high prevalence of tetA, sul1, sul2, and bla TEM resistance genes among multidrug-resistant Uropathogenic Escherichia coli (UPEC) strains in Malaysia.
Escherichia coli ST117: exploring the zoonotic hypothesis.
The study identified several AMR genes in E. coli ST117 isolates from Brazilian poultry outbreaks, including bla CTX-M-55, bla CTX-M-8, bla TEM-1, mcr-1.1, and fosA3, which confer resistance to cephalosporins, penicillins, colistin, and fosfomycin.
Molecular characterization of superbugs K. pneumoniae harboring extended-spectrum beta-lactamase (ESBL) and carbapenemase resistance genes among hospitalized patients in southwestern Iran, Western Asia.
The study identified several AMR genes in K. pneumoniae isolates, including blaSHV, blaTEM, blaCTX-M, blaOXA-48, and blaVIM, which confer resistance to various β-lactam antibiotics. These genes were detected in clinical isolates from hospitalized patients in southwestern Iran.
Prevalence, risk factors, and characterisation of extended-spectrum β-lactamase -producing Enterobacterales (ESBL-E) in horses entering an equine hospital and description of longitudinal excretion.
The study identified ESBL-E in 3% of horses admitted to an equine hospital, with specific beta-lactamase genes (blaCTX-M-1, blaCTX-M-14, blaTEM, blaSHV, blaOXA) and other resistance genes (aac(6')-lb-cr, catB3) contributing to multidrug resistance.
Assessment of the presence of multidrug-resistant Escherichia coli, Salmonella and Staphylococcus in chicken meat, eggs and faeces in Mymensingh division of Bangladesh.
The study identified multiple AMR genes in E. coli, Salmonella spp., and Staphylococcus aureus isolated from chicken meat, eggs, and faeces in Bangladesh, highlighting the presence of multidrug-resistant pathogens.
The ISVsa3-ORF2-abh-tet(X4) circular intermediate-mediated transmission of tigecycline resistance in Escherichia coli isolates from duck farms.
The study identifies the tet(X4) gene in E. coli isolates from duck farms, demonstrating its presence in a circular intermediate and its ability to transfer via conjugation, highlighting the potential for widespread tigecycline resistance.
Culture and amplification-free nanopore sequencing for rapid detection of pathogens and antimicrobial resistance genes from urine.
The study demonstrates the successful detection of various antimicrobial resistance genes, including blaCTX-M-15, blaCTX-M-2, blaTEM-1, blaSHV, catA, tet(J), blaOXA-356, fosB, and mepA, using nanopore sequencing in spiked urine samples.
Antibiotic Resistance Genes and Plasmid Characteristics in Enterobacteriaceae Isolated from Fresh Produce
The study identified several antibiotic resistance genes on plasmids and chromosomes of Enterobacteriaceae strains isolated from fresh produce, highlighting the diversity of resistance mechanisms and the potential for horizontal gene transfer.
Evaluation of an expanded antibiotic resistance gene panel on prediction of antimicrobial susceptibility results for Gram-negative bacteria in blood cultures.
The study evaluated the QIAstat-Dx BCID panel for detecting antibiotic resistance genes in Gram-negative bacteria from blood cultures. It found that the panel effectively identified several resistance genes, including bla CTX-M, bla KPC, bla NDM, and others, which are crucial for predicting antimicrobial susceptibility. The panel showed high sensitivity and specificity for identifying resistance genes and predicting susceptibility, especially for beta-lactam antibiotics.
Antibiotic resistance, virulence genes, and phylogenetic groups of bacteria isolated from wild passerine birds in Iran.
The study identified tetracycline resistance genes (tet(A), tet(B), tet(M), tet(L)) and the blaTEM gene associated with ampicillin resistance in bacteria isolated from wild passerine birds in Iran.
Complete genome of Escherichia coli sequence type 73 with acquired blaTEM-1 and high genotypic virulence load identified in human saliva.
The study reports the complete genome of a genomically hypervirulent E. coli ST73 strain carrying the acquired blaTEM-1 gene, which confers resistance to ampicillin and piperacillin.
Analysis of the Association Between Antimicrobial Resistance Genes and Virulence Factors in ST11 and Non-ST11 CR-KP Bloodstream Infections in the Intensive Care Unit.
The study identifies bla KPC-2 as the primary carbapenemase in ST11 CR-KP, with higher carriage rates compared to non-ST11 CR-KP. It also detects bla NDM-5 in non-ST11 CR-KP and bla OXA-23 in some strains. The study highlights the higher resistance rates of ST11 CR-KP to various antibiotics and its increased virulence gene carriage.
Molecular insights into the evolutionary trajectory of a Klebsiella aerogenes clinical isolate with a complex trade-off between resistance and virulence.
Molecular insights into the evolutionary trajectory of a Klebsiella aerogenes clinical isolate with a complex trade-off between resistance and virulence.
Genomic Characterization of Extended-Spectrum beta-lactamase-Producing and Third-Generation Cephalosporin-Resistant Escherichia coli Isolated from Stools of Primary Healthcare Patients in Ethiopia.
The study identified multiple antimicrobial resistance genes in E. coli isolates, including bla CTX-M-15, bla TEM-1B, tet(A), qnrS1, and others, highlighting the prevalence of multidrug resistance in the region.
Comprehensive Genomic Analysis of Uropathogenic E. coli: Virulence Factors, Antimicrobial Resistance, and Mobile Genetic Elements.
The study identified numerous antimicrobial resistance genes and mutations in uropathogenic E. coli isolates, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and quinolone resistance genes. Mutations in gyrA, parC, parE, and marR were associated with fluoroquinolone resistance, while mutations in PmrB, CyaA, GlpT, PtsI, and UhpT were linked to fosfomycin resistance.
Investigation on the mechanisms of carbapenem resistance among the non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae.
The study identified non-carbapenemase β-lactamase genes and chromosomal mutations, including missense mutation or loss of ompK36 porin and frameshift missense mutation in efflux pump systems, as potential mechanisms of carbapenem resistance in NC-CRKP.
Predominance of enterotoxigenic Escherichia coli among ESBL/plasmid-mediated AmpC-producing strains isolated from diarrheic foals: a public health concern.
The study identified ESBL and pAmpC-producing E. coli strains in diarrheic foals, highlighting the presence of bla TEM, bla CTX-M, bla SHV, bla OXA, and bla CMY-2 genes, along with the heat-stable enterotoxin (ST) gene, indicating a public health concern.
Exploring uncatalogued genetic variation in antimicrobial resistance gene families in Escherichia coli: an observational analysis.
The study identifies significant uncatalogued genetic variation in antimicrobial resistance gene families in E. coli, particularly within the bla TEM-1 gene family. Synonymous mutations in bla TEM-1 variants were associated with reduced resistance to amoxicillin-clavulanic acid and piperacillin-tazobactam.
High prevalence of multi-drug resistant organisms in the gut flora of healthy rural individuals in northern India.
The study found a high prevalence of multi-drug resistant organisms in the gut flora of healthy rural individuals in northern India, with a significant presence of ESBL and carbapenemase genes such as bla TEM, bla SHV, bla CTXM-1, and OXA-48.
Occurrence of Extended-spectrum beta-lactamase (ESBL) and Carbapenemase-producing Escherichia coli isolated from Childhood Diarrhoea in Yaoundé, Cameroon.
The study identified several AMR genes, including bla CTX−M, bla TEM, bla OXA−48, tet(A), and tet(B), in ESBL-producing E. coli isolates from childhood diarrhoea in Yaoundé, Cameroon. These genes confer resistance to various antibiotics, highlighting the urgent need for improved surveillance and antimicrobial stewardship.
High prevalence of colonization with extended-spectrum β-lactamase-producing and multidrug-resistant Enterobacterales in the community in Addis Ababa Ethiopia: risk factors, carbapenem resistance, and molecular characterization.
The study identified bla TEM and bla CTX-M as the most prevalent ESBL genes in ESBL-producing Enterobacterales, with bla TEM being the dominant gene. bla CTX-M was also significantly represented. Both genes were associated with resistance to various beta-lactam antibiotics.
Whole genome analysis of Pantoea species identified from sepsis patients in selected Ethiopian referral hospitals: emerging pathogens.
The study identified multiple Pantoea species, including P. dispersa, P. septica, and a novel Pantoea species, carrying various antimicrobial resistance genes such as blaCTX-M-15, blaSCO-1, blaTEM-1D, aac(3)-IIa, and blaCTX-M-9. These genes conferred resistance to multiple antibiotics, highlighting the emergence of multidrug-resistant Pantoea isolates in Ethiopian referral hospitals.
Metagenomic assemblies tend to break around antibiotic resistance genes.
The study evaluates the performance of various metagenomic assemblers in capturing antibiotic resistance genes (ARGs) and their genomic contexts, highlighting challenges in accurately reconstructing ARGs from short-read data.
Characterisation of Antimicrobial Resistance in Special-Fed Veal Production Environments.
The study identified qnrS1 and blaTEM-1B as key genes contributing to fluoroquinolone and beta-lactam resistance in E. coli isolates from veal calf environments.
Role of migratory birds as a risk factor for the transmission of multidrug resistant Salmonella enterica and Escherichia coli to broiler poultry farms and its surrounding environment.
The study identified several AMR genes, including Sul1, Tet A (A), bla TEM, ere A, and qnrA, in multidrug-resistant Salmonella enterica and Escherichia coli isolated from migratory birds and broiler poultry farms.
Enterobacterales Producing ESBLs and AmpC in Fresh Vegetables from Tebessa City, Algeria.
The study identified various ESBL genes, including bla CTX-M-79, bla CTX-M-107, bla CTX-M-117, bla TEM-112, bla TEM-125, bla TEM-194, and bla SHV-176, in Enterobacterales isolated from fresh vegetables in Tebessa, Algeria.
Enterobacterales Producing ESBLs and AmpC in Fresh Vegetables from Tebessa City, Algeria.
The study identified various ESBL genes, including bla CTX-M-79, bla CTX-M-107, bla CTX-M-117, bla TEM-112, bla TEM-125, bla TEM-194, and bla SHV-176, in Enterobacterales isolated from fresh vegetables in Tebessa, Algeria.
Enterobacterales Producing ESBLs and AmpC in Fresh Vegetables from Tebessa City, Algeria.
The study identified various ESBL genes, including bla CTX-M-79, bla CTX-M-107, bla CTX-M-117, bla TEM-112, bla TEM-125, bla TEM-194, and bla SHV-176, in Enterobacterales isolated from fresh vegetables in Tebessa, Algeria.
Prevalence and Molecular Epidemiology of Intestinal Colonization by Multidrug-Resistant Bacteria among Hematopoietic Stem-Cell Transplantation Recipients: A Bulgarian Single-Center Study.
The study identified several AMR genes including bla CTX-M, bla TEM, bla SHV, bla VIM, and vanA in multidrug-resistant bacteria isolated from HSCT recipients. These genes were associated with resistance to various antibiotics such as beta-lactams, carbapenems, and glycopeptides.
Prevalence, Characterization, and Epidemiological Relationships between ESBL and Carbapenemase-Producing Escherichia coli, Klebsiella pneumoniae, and Acinetobacter spp. Isolated from Humans and the Kitchen Environment of Two Greek Hospitals.
The study identified various beta-lactamase genes, including bla SHV, bla CTX-M, bla TEM, bla KPC, bla NDM, bla OXA-48, bla OXA-23, and bla OXA-51, in ESBL and carbapenemase-producing E. coli, K. pneumoniae, and Acinetobacter spp. isolates from hospital kitchens and staff.
Genomic Characterization of 16S rRNA Methyltransferase-Producing Enterobacterales Reveals the Emergence of Klebsiella pneumoniae ST6260 Harboring rmtF, rmtB, bla(NDM-5), bla(OXA-232) and bla(SFO-1) Genes in a Cancer Hospital in Bulgaria.
The study identifies the emergence of Klebsiella pneumoniae ST6260 harboring multiple AMR genes, including rmtF, rmtB, bla(NDM-5), bla(OXA-232), and bla(SFO-1), highlighting the complexity of resistance mechanisms in Enterobacterales.
Genotypic Characterisation and Antimicrobial Resistance of Extended-Spectrum beta-lactamase-Producing Escherichia coli in Humans, Animals, and the Environment from Lusaka, Zambia: Public Health Implications and One Health Surveillance.
The study identified bla CTX-M-15, bla NDM-5, bla OXA-1, and bla TEM as the main AMR genes in ESBL-producing E. coli isolates from Lusaka, Zambia. These genes confer resistance to various β-lactam antibiotics, highlighting the need for improved surveillance and infection control measures.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Characterization of Extraintestinal Pathogenic Escherichia coli Strains Causing Canine Pneumonia in China: Antibiotic Resistance, Virulence Genes, and Sequence Typing.
Four multidrug-resistant strains of extraintestinal pathogenic Escherichia coli (ExPEC) were identified in puppies with acute pneumonia, carrying resistance genes such as TEM, CTX-M-55, mec, tet, AAC-IId, cmlA, dfrA, and sul. These strains were classified as ST131 or ST43 and showed resistance to cephalosporins, tetracyclines, and penicillins, but were susceptible to aminoglycosides, beta-lactamase inhibitors, carbapenems, chloramphenicols, and sulfonamides.
Multidrug-resistant Salmonella Typhi among symptomatic and asymptomatic children in informal settlements in Nairobi, Kenya.
The study identified blaTEM-1 as a prevalent multidrug resistance gene in Salmonella Typhi isolates from both symptomatic and asymptomatic children in Nairobi, Kenya.
Molecular Characterization of Carbapenem and Colistin Resistance in Klebsiella pneumoniae Isolates Obtained from Clinical Samples at a University Hospital Center in Algeria.
A single-center analysis of clonal transmission of carbapenem-resistant Acinetobacter baumannii among intensive care unit patients during the COVID-19 pandemic.
The study identified multiple carbapenem-resistant Acinetobacter baumannii isolates carrying various resistance genes, including bla OXA-40, ISAba-1, int-2, bla OXA-23, bla NDM-1, and several ESBL genes. These findings highlight the complex resistance profiles and clonal transmission of CRAB in ICU settings during the COVID-19 pandemic.
Prevalence and Risk Factors of beta-lactamase Genes of Extended-Spectrum beta-lactamases-Producing Escherichia coli From Dairy Farm Environments of Haryana, India.
The study identified bla CTX-M and bla TEM genes as the most prevalent beta-lactamase genes in ESBL-producing E. coli isolates from dairy farm environments in Haryana, India.
Virulence and Antimicrobial Resistance Patterns of Salmonella spp. Recovered From Migratory and Captive Wild Birds.
The study identified the presence of AMR genes blaTEM, blaSHV, sul1, and tet(A) in Salmonella spp. recovered from migratory and captive wild birds, highlighting the potential for these birds to act as reservoirs of multidrug-resistant bacteria.
Myroides species, pathogenic spectrum and clinical microbiology sight in Mexican isolates.
The study identified multiple AMR genes in Myroides spp. isolates, including beta-lactamases (blaIMP-27, blaIMP-35, blaGOB-16, blaMUS-1, blaOXA-229, blaOXA-351, blaOXA-97), erythromycin esterase (ereB), and polymyxin resistance genes (mcr-3.6, mcr-3.7, mcr-3.10), indicating a high level of multidrug resistance.
The characterization of an IncN-IncR fusion plasmid co-harboring bla(TEM-40), bla(KPC-2), and bla(IMP-4) derived from ST1393 Klebsiella pneumoniae.
The study characterizes a novel IncN-IncR fusion plasmid carrying bla(KPC-2), bla(IMP-4), and bla(TEM-40) genes, along with qnrS1, in a ST1393 Klebsiella pneumoniae strain. The plasmid was found to confer resistance to multiple carbapenems and other antibiotics.
Pyoverdine-antibiotic combination treatment: its efficacy and effects on resistance evolution in Escherichia coli.
The study identifies mutations in ompF and envZ as conferring resistance to ceftazidime, and mutations in the opp-operon as contributing to pyoverdine resistance in E. coli.
Evaluation of the QIAstat-Dx BCID GN and GPF kits for direct identification and antimicrobial resistance prediction from blood culture bottles.
The QIAstat-Dx BCID GN and GPF kits showed high accuracy in detecting AMR genes such as blaZ, mecA, ermC, aac(6')-lb, ctx-m, ampC, shv, tem, tetM, and aac(6')/aph(2") in various bacteria, correlating well with phenotypic resistance results.
Public health concern of antimicrobial resistance and virulence determinants in E. coli isolates from oysters in Egypt.
The study identified multiple AMR genes in E. coli isolates from oysters in Egypt, including bla TEM, bla CTX-M, bla SHV, bla OXA-1, bla CMY-2, bla KPC, bla NDM, bla OXA-48, and bla VIM, as well as virulence genes such as papC, sfa, exhA, eaeA, and estA.
Prevalence and clinical significance of the genotypic carriage among ESBL phenotype-negative Escherichia coli and Klebsiella pneumoniae clinical isolates in bacteremia: a study in a Malaysian tertiary center.
The study identified the prevalence of bla CTX-M, bla SHV, bla TEM, and bla OXA-1 genes in ESBL phenotype-negative Escherichia coli and Klebsiella pneumoniae isolates from bacteremia cases in a Malaysian hospital. These genes were found to be associated with resistance to cephalosporins.
Antimicrobial Resistance in Wastewater Samples from Kumasi, Ghana: A Genomic and Metagenomic Analysis
The study identified several AMR genes and mutations in P. aeruginosa and K. pneumoniae isolates from wastewater samples in Kumasi, Ghana, highlighting the presence of multidrug-resistant strains carrying genes such as blaCTX-M-15, blaOXA-488, and qnrVC1, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Antimicrobial Resistance and Pathotypes of Escherichia coli Isolates from Yellow-Legged Seagulls (Larus michahellis) in Central Italy.
The study identified various AMR genes in E. coli isolates from yellow-legged seagulls, including bla TEM, bla OXA-48, bla CMY2, bla SHV, and bla CTX, indicating the presence of multidrug-resistant and extensively drug-resistant strains.
Assessment of Bacterial Contamination and Antimicrobial Resistance of Escherichia coli Isolates from Slovak Dairy Farms.
The study identified several antimicrobial resistance genes in E. coli isolates from Slovak dairy farms, including bla TEM, bla SHV, bla CMY, sul 1, sul 2, tet B, and qnr S, which confer resistance to various antibiotics such as beta-lactams, sulfonamides, tetracyclines, and quinolones.
A nosocomial outbreak of colistin and carbapenem-resistant hypervirulent Klebsiella pneumoniae in a large teaching hospital.
Neural network-based predictions of antimicrobial resistance phenotypes in multidrug-resistant Acinetobacter baumannii from whole genome sequencing and gene expression.
The study presents a deep neural network model capable of predicting antimicrobial resistance phenotypes in multidrug-resistant Acinetobacter baumannii using whole genome sequencing and gene expression data. The model achieves high accuracy in predicting resistance to various antibiotics, including β-lactams, aminoglycosides, and carbapenems.
Genomic characterisation of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate assigned to a novel sequence type (6914).
The study reports the genomic characterization of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate, Cow102, which exhibits multidrug resistance. It identifies several resistance genes, including blaSHV-1, blaSHV-11, blaSHV-13, blaSHV-26, blaSHV-70, blaSHV-78, blaSHV-98, blaSHV-145, blaTEM-1B, aadA2, catA2, catII, dfrA16, fosA, oqxA, oqxB, sul1, sul2, and tet(D).
Survey in ruminants from Rwanda revealed high diversity and prevalence of extended-spectrum cephalosporin-resistant Enterobacterales.
The study identified various extended-spectrum cephalosporin-resistant Enterobacterales in ruminants from Rwanda, including multiple beta-lactamase genes such as bla CTX-M-15, bla TEM-1, and others, along with non-beta-lactam resistance genes like tet(A), sul2, and qnrS1.
Genome and antibiotic resistance characteristics of Shigella clinical isolates in Fujian Province, Southeast China, 2005-2019.
The study identified various AMR genes in Shigella isolates from Fujian Province, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla CTX-M-64), macrolide resistance genes (mphA, ermB), tetracycline resistance genes (tetA, tetB), aminoglycoside resistance genes (aadA, aph(3')-Ib, aac(3)-IId), chloramphenicol resistance gene (catA1), and sulfonamide/trimethoprim resistance genes (sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA17).
Genome and antibiotic resistance characteristics of Shigella clinical isolates in Fujian Province, Southeast China, 2005-2019.
The study identified various AMR genes in Shigella isolates from Fujian Province, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla CTX-M-64), macrolide resistance genes (mphA, ermB), tetracycline resistance genes (tetA, tetB), aminoglycoside resistance genes (aadA, aph(3')-Ib, aac(3)-IId), chloramphenicol resistance gene (catA1), and sulfonamide/trimethoprim resistance genes (sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA17).
Genomic epidemiology and phenotypic characterisation of Salmonella enterica serovar Panama in Victoria, Australia.
The study identifies the first plasmid-mediated colistin-resistant Salmonella enterica serovar Panama in Australia, highlighting the emergence of multidrug resistance in this invasive non-typhoidal Salmonella serovar.
Genomic epidemiology and phenotypic characterisation of Salmonella enterica serovar Panama in Victoria, Australia.
The study identifies the first plasmid-mediated colistin-resistant Salmonella enterica serovar Panama in Australia, highlighting the emergence of multidrug resistance in this invasive non-typhoidal Salmonella serovar.
Effect of Moringa oleifera seeds on the removal of pathogens and pharmaceutical residues in a domestic wastewater treatment plant by an interdisciplinary approach.
The study found that Moringa oleifera seeds (MOS) effectively reduced the abundance of antibiotic resistance genes (ARGs) such as bla CTX-M, bla SHV, and bla TEM in wastewater. MOS treatment significantly decreased the copy numbers of these genes, indicating potential for mitigating antibiotic resistance in wastewater treatment.
The role of New World vultures as carriers of environmental antimicrobial resistance.
The study identified several antimicrobial resistance genes (ARGs) in environmental samples collected from New World vultures, including blaTEM, sul1, ermA, ermF, tetA, and tetB, which confer resistance to beta-lactams, sulfonamides, macrolides, and tetracyclines. These genes were detected in Escherichia coli, enterococci, and Salmonella spp. across different sampling sites and seasons.
Increased Severity of Multidrug-Resistant Shigella sonnei Infections in People Experiencing Homelessness.
The study identifies a clonal expansion of multidrug-resistant Shigella sonnei (genotype 3.6.1.1.2) with resistance to multiple antibiotics, including ampicillin, trimethoprim-sulfamethoxazole, ciprofloxacin, and azithromycin.
Escherichia coli from six European countries reveals differences in profile and distribution of critical antimicrobial resistance determinants within One Health compartments, 2013 to 2020.
The study identified various AMR genes in E. coli isolates from different sources in six European countries, highlighting differences in resistance profiles and the prevalence of specific resistance mechanisms such as beta-lactamases, quinolone resistance genes, and tetracycline resistance genes.
Prevalence and molecular characterization of ESBL-producing Escherichia coli isolated from broiler chicken and their respective farms environment in Malaysia.
The study identified bla TEM, bla CTX-M, and bla SHV as the primary ESBL genes in ESBL-producing E. coli isolates from broiler chickens and their farm environment in Malaysia. These genes conferred resistance to multiple antibiotics, including beta-lactams, tetracycline, and chloramphenicol.
First Detection of High-Level Aminoglycoside-Resistant Klebsiella pneumoniae and Enterobacter cloacae Isolates Due to 16S rRNA Methyltransferases with and Without bla(NDM) in Uruguay.
The study identifies the first detection of high-level aminoglycoside-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates in Uruguay, carrying 16S rRNA methyltransferases (rmtB, rmtC, rmtD) along with carbapenemase genes (bla NDM-5, bla NDM-1).
First Detection of High-Level Aminoglycoside-Resistant Klebsiella pneumoniae and Enterobacter cloacae Isolates Due to 16S rRNA Methyltransferases with and Without bla(NDM) in Uruguay.
The study identifies the first detection of high-level aminoglycoside-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates in Uruguay, carrying 16S rRNA methyltransferases (rmtB, rmtC, rmtD) along with carbapenemase genes (bla NDM-5, bla NDM-1).
Data-Driven Approaches in Antimicrobial Resistance: Machine Learning Solutions.
This study uses unsupervised machine learning to identify patterns in AMR genes, linking gene length and resistance class to resistance mechanisms. Key AMR genes identified include sul1, sul2, cat, blaTEM, vanA, aac(6')-Ib, aph(3')-IIIa, tet(M), and tet(O).
Interrelation Between Pathoadaptability Factors and Crispr-Element Patterns in the Genomes of Escherichia coli Isolates Collected from Healthy Puerperant Women in Ural Region, Russia.
The study identified several AMR genes in E. coli isolates from healthy puerperant women, including beta-lactamases (bla CTX-M-15, bla TEM-1C, bla DHA-1, bla CTX-M-27, bla TEM-1B, bla OXA-1), aminoglycoside resistance genes (aadA5, dfrA17), and a fosfomycin resistance gene (fosA).
Interrelation Between Pathoadaptability Factors and Crispr-Element Patterns in the Genomes of Escherichia coli Isolates Collected from Healthy Puerperant Women in Ural Region, Russia.
The study identified several AMR genes in E. coli isolates from healthy puerperant women, including beta-lactamases (bla CTX-M-15, bla TEM-1C, bla DHA-1, bla CTX-M-27, bla TEM-1B, bla OXA-1), aminoglycoside resistance genes (aadA5, dfrA17), and a fosfomycin resistance gene (fosA).
Antimicrobial Resistance Profile of Zoonotic Clinically Relevant WHO Priority Pathogens.
The study identified blaTEM and blaAmpC genes in various zoonotic pathogens, contributing to multidrug resistance against beta-lactam antibiotics.
Antibiotic resistance genotype, phenotype, and clinical outcomes in patients with Gram-negative infections at Rabin Medical Center in Israel.
The study identified blaCTX-M-15 as associated with multidrug-resistance in E. coli, blaOXA-72 copy number as predictive of meropenem MIC in A. baumannii, and RJX84154 as associated with multidrug-resistance across multiple pathogens.
Characteristics and antibiotic resistance patterns of urinary tract isolates in hospitalized and non-hospitalized patients: a cross-sectional study in Khartoum, Sudan.
The study identified CTX-M genes as a significant cause of extended-spectrum beta-lactamase (ESBL) production in urinary tract isolates, particularly in Escherichia coli and Klebsiella spp.
Salmonella Typhi Haplotype 58 biofilm formation and genetic variation in isolates from typhoid fever patients with gallstones in an endemic setting in Kenya.
The study identified multidrug resistance genes sul1, dfrA7, catA1, aph(6)-Id, aph(3" )-Ib, sul2, and blaTEM-1 in S. Typhi isolates from household D, along with specific mutations in the quinolone resistance-determining region (QRDR) of gyrA and gyrB. Additionally, missense mutations in the treB and tviE genes were observed in isolates from different households.
AmpC beta-lactamases detected in Southeast Asian Escherichia coli and Klebsiella pneumoniae.
The study identifies various beta-lactamase genes, including bla CMY-2, bla CMY-42, bla DHA-1, bla NDM-5, bla OXA-1, and bla TEM-1, which confer resistance to multiple antibiotics in Escherichia coli and Klebsiella pneumoniae isolates from Southeast Asia.
Emerging epidemic of the Africa-type plasmid in penicillinase-producing Neisseria gonorrhoeae in Guangdong, China, 2013-2022.
The study identifies various blaTEM alleles, including blaTEM-1, blaTEM-135, and several new alleles, which are associated with penicillin resistance in penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates in Guangdong, China. The Africa-type plasmid became the predominant plasmid type, replacing the Asia-type plasmid.
Emerging epidemic of the Africa-type plasmid in penicillinase-producing Neisseria gonorrhoeae in Guangdong, China, 2013-2022.
The study identifies various blaTEM alleles, including blaTEM-1, blaTEM-135, and several new alleles, which are associated with penicillin resistance in penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates in Guangdong, China. The Africa-type plasmid became the predominant plasmid type, replacing the Asia-type plasmid.
Emerging epidemic of the Africa-type plasmid in penicillinase-producing Neisseria gonorrhoeae in Guangdong, China, 2013-2022.
The study identifies various blaTEM alleles, including blaTEM-1, blaTEM-135, and several new alleles, which are associated with penicillin resistance in penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates in Guangdong, China. The Africa-type plasmid became the predominant plasmid type, replacing the Asia-type plasmid.
Emerging epidemic of the Africa-type plasmid in penicillinase-producing Neisseria gonorrhoeae in Guangdong, China, 2013-2022.
The study identifies various blaTEM alleles, including blaTEM-1, blaTEM-135, and several new alleles, which are associated with penicillin resistance in penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates in Guangdong, China. The Africa-type plasmid became the predominant plasmid type, replacing the Asia-type plasmid.
Emerging epidemic of the Africa-type plasmid in penicillinase-producing Neisseria gonorrhoeae in Guangdong, China, 2013-2022.
The study identifies various blaTEM alleles, including blaTEM-1, blaTEM-135, and several new alleles, which are associated with penicillin resistance in penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates in Guangdong, China. The Africa-type plasmid became the predominant plasmid type, replacing the Asia-type plasmid.
Emerging epidemic of the Africa-type plasmid in penicillinase-producing Neisseria gonorrhoeae in Guangdong, China, 2013-2022.
The study identifies various blaTEM alleles, including blaTEM-1, blaTEM-135, and several new alleles, which are associated with penicillin resistance in penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates in Guangdong, China. The Africa-type plasmid became the predominant plasmid type, replacing the Asia-type plasmid.
Emerging epidemic of the Africa-type plasmid in penicillinase-producing Neisseria gonorrhoeae in Guangdong, China, 2013-2022.
The study identifies various blaTEM alleles, including blaTEM-1, blaTEM-135, and several new alleles, which are associated with penicillin resistance in penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates in Guangdong, China. The Africa-type plasmid became the predominant plasmid type, replacing the Asia-type plasmid.
Emerging epidemic of the Africa-type plasmid in penicillinase-producing Neisseria gonorrhoeae in Guangdong, China, 2013-2022.
The study identifies various blaTEM alleles, including blaTEM-1, blaTEM-135, and several new alleles, which are associated with penicillin resistance in penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates in Guangdong, China. The Africa-type plasmid became the predominant plasmid type, replacing the Asia-type plasmid.
Emerging epidemic of the Africa-type plasmid in penicillinase-producing Neisseria gonorrhoeae in Guangdong, China, 2013-2022.
The study identifies various blaTEM alleles, including blaTEM-1, blaTEM-135, and several new alleles, which are associated with penicillin resistance in penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates in Guangdong, China. The Africa-type plasmid became the predominant plasmid type, replacing the Asia-type plasmid.
Emerging epidemic of the Africa-type plasmid in penicillinase-producing Neisseria gonorrhoeae in Guangdong, China, 2013-2022.
The study identifies various blaTEM alleles, including blaTEM-1, blaTEM-135, and several new alleles, which are associated with penicillin resistance in penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates in Guangdong, China. The Africa-type plasmid became the predominant plasmid type, replacing the Asia-type plasmid.
Emerging epidemic of the Africa-type plasmid in penicillinase-producing Neisseria gonorrhoeae in Guangdong, China, 2013-2022.
The study identifies various blaTEM alleles, including blaTEM-1, blaTEM-135, and several new alleles, which are associated with penicillin resistance in penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates in Guangdong, China. The Africa-type plasmid became the predominant plasmid type, replacing the Asia-type plasmid.
Genomic perspective on the bacillus causing paratyphoid B fever.
The study identified mutations in the gyrA gene associated with reduced susceptibility to fluoroquinolones in Salmonella enterica serotype paratyphi B strains.
The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes.
The study characterizes various resistance genes carried by incompatible plasmids in Gram-negative bacteria, highlighting their role in the spread of antibiotic resistance. Key genes include beta-lactamases like bla VIM-1, bla SHV-12, bla TEM-1B, and bla CTX-M-15, as well as sulfonamide resistance genes sul1 and sul2, tetracycline resistance gene tetA, and polymyxin resistance gene mcr-1.
Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307.
The study identifies the colistin resistance gene mcr-8.1 in multidrug-resistant Klebsiella pneumoniae ST307 isolates from Armenia, highlighting the emergence of this gene in the region.
A single-center retrospective study of the molecular epidemiological characteristics of different Klebsiella pneumoniae infections in northern China.
The study identified multidrug-resistant ST11 and hypervirulent ST23 as prevalent Klebsiella pneumoniae strains in northern China, highlighting the co-harborance of resistance genes such as rmtB, TEM-1, and KPC-2 in ST11 strains.
Characterizing Methicillin-Resistant Staphylococcus spp. and Extended-Spectrum Cephalosporin-Resistant Escherichia coli in Cattle.
The study identified several AMR genes in E. coli and MRSA isolates from cattle in Austria, including bla CTX-M-1/15, bla CTX-M-9, bla TEM, tet (A), tet (B), dfrA1, dfrA5, dfrA14, dfrA17, sul2, sul3, aadA1, aadA2, floR, cmlA, aphA, and bla ACT. Additionally, the MRSA isolate carried the mecA gene, indicating methicillin resistance.
Genomic and virulent characterization of a duck-associated Salmonella serovar Potsdam from China.
The study identified several antimicrobial resistance genes and mutations in Salmonella serovar Potsdam isolated from duck embryos, including aac(3')-Ia, aac(4')-IIa, aph(3')-IIa, aph(3')'-Ib, aph(6')-Id, blaTEM-116, blaTEM-1B, and tet(A), as well as gyrA and parC mutations associated with quinolone resistance.
Genomic and virulent characterization of a duck-associated Salmonella serovar Potsdam from China.
The study identified several antimicrobial resistance genes and mutations in Salmonella serovar Potsdam isolated from duck embryos, including aac(3')-Ia, aac(4')-IIa, aph(3')-IIa, aph(3')'-Ib, aph(6')-Id, blaTEM-116, blaTEM-1B, and tet(A), as well as gyrA and parC mutations associated with quinolone resistance.
Molecular and clinical insights into extended-spectrum beta-lactamase genes of Klebsiella pneumoniae isolated from neonatal sepsis in Ethiopia.
The study identified blaCTX-M, blaTEM, and blaSHV as the most prevalent extended-spectrum beta-lactamase genes in Klebsiella pneumoniae isolates from neonatal sepsis in Ethiopia, with significant correlations between blaSHV and neonatal mortality.
Fecal carriage of ESBL-producing E. coli and genetic characterization in rural children and livestock in the Somali region, Ethiopia: a one health approach.
The study identified bla CTX-M-15 as the most prevalent ESBL gene in both human and animal E. coli isolates, along with other resistance genes such as bla TEM-1B, bla OXA-1, and various aminoglycoside, sulfonamide, and trimethoprim resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Fecal carriage of ESBL-producing E. coli and genetic characterization in rural children and livestock in the Somali region, Ethiopia: a one health approach.
The study identified bla CTX-M-15 as the most prevalent ESBL gene in both human and animal E. coli isolates, along with other resistance genes such as bla TEM-1B, bla OXA-1, and various aminoglycoside, sulfonamide, and trimethoprim resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Epidemiology and Molecular Characterisation of Multidrug-Resistant Escherichia coli Isolated from Cow Milk.
The study identified several AMR genes in multidrug-resistant E. coli isolates from cow milk, including bla TEM, bla CTX-M, bla OXA-1, bla OXA-2, bla CMY-1, tet A, tet B, tet D, sul -1, and sul -2, which confer resistance to various antibiotics.
Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics.
The study demonstrates that CRISPR interference (CRISPRi) can re-sensitize laboratory strains and clinical isolates to last-resort antibiotics by repressing the expression of specific antibiotic resistance genes (ARGs).
Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics.
The study demonstrates that CRISPR interference (CRISPRi) can re-sensitize laboratory strains and clinical isolates to last-resort antibiotics by repressing the expression of specific antibiotic resistance genes (ARGs).
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
The fly route of extended-spectrum-β-lactamase-producing Enterobacteriaceae dissemination in a cattle farm: from the ecosystem to the molecular scale.
The study identifies bla CTX-M-15 and bla TEM-1B as key resistance genes in ESBL-producing E. coli and Enterobacter cloacae complex Taxon 4 isolates from a cattle farm, highlighting their role in resistance and the potential of flies as vectors for their dissemination.
Prevalence and genetic characterization of clinically relevant extended-spectrum beta-lactamase-producing Enterobacterales in the Gulf Cooperation Council countries.
The study identifies bla CTX-M, bla TEM, and bla SHV as the most prevalent extended-spectrum beta-lactamase (ESBL) genes in Enterobacterales from the Gulf Cooperation Council (GCC) region, contributing to multidrug resistance. Additionally, bla OXA-48 and bla NDM-1 are noted as significant carbapenem-resistance genes.
Allele distribution and phenotypic resistance to ciprofloxacin and gentamicin among extended-spectrum β-lactamase-producing Escherichia coli isolated from the urine, stool, animals, and environments of patients with presumptive urinary tract infection in Tanzania.
The study identified bla CTX-M, bla TEM, and bla SHV as the most prevalent extended-spectrum beta-lactamase (ESBL) alleles in E. coli isolates from various sources in Tanzania. High resistance to ciprofloxacin and gentamicin was observed among ESBL-producing E. coli isolates.
Multidrug-resistant ST11-KL64 hypervirulent Klebsiella pneumoniae with multiple bla- genes isolated from children's blood.
Phenotypic and genotypic characterization of antimicrobial resistance and virulence profiles of Salmonella enterica serotypes isolated from necropsied horses in Kentucky.
The study identified several AMR genes in Salmonella enterica isolates from necropsied horses, including beta-lactamase genes (blaTEM, blaCTX-M, blaSHV2, blaOXA-9), aminoglycoside resistance gene (aacA[3]), sulfonamide resistance gene (sul2), amphenicol resistance gene (floR), tetracycline resistance gene (tetB), streptomycin resistance gene (strA), macrolide resistance gene (ermB2), and quinolone resistance gene (qnrB2). These genes were associated with resistance to multiple antibiotics, highlighting the presence of multidrug-resistant Salmonella strains.
High prevalence of multidrug resistant and extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolated from urinary tract infections in the West region, Cameroon.
The study identified bla CTX−M and bla TEM as the most prevalent resistance genes among ESBL-producing E. coli and K. pneumoniae isolated from urinary tract infections in the West region of Cameroon.
Prevalence, Characterization, and Proteomic Relatedness Among β-Lactam-Resistant Bacteria Throughout the Poultry Production Chain in Greece.
The study identified various β-lactamase genes, including bla CTX-M, bla TEM, bla SHV, and bla OXA-1, in β-lactam-resistant bacteria from poultry farms and slaughterhouses in Greece.
Emerging Resistance and Virulence Patterns in Salmonella enterica: Insights into Silver Nanoparticles as an Antimicrobial Strategy.
The study identified various AMR genes in Salmonella enterica isolates, including blaTEM-1, aadA1, aadA2, aadA5, ant(2")-Ia, aph(3")-Ib, aph(6)-Id, mph(A), tet(A), tet(B), sul1, sul2, sul3, qnrA1, qnrB19, dfrA5, dfrA12, dfrA17, cmlA1, and cmlA5, which confer resistance to β-lactams, aminoglycosides, tetracyclines, sulfonamides, fluoroquinolones, trimethoprim, and chloramphenicol.
Monitoring the Spread of Multidrug-Resistant Escherichia coli Throughout the Broiler Production Cycle.
The study identified the presence of ESBL genes (bla CTX-M, bla TEM, and bla SHV) in multidrug-resistant E. coli isolates from broiler farms in southern Brazil, highlighting the spread of resistance mechanisms in poultry production.
Assessment of Antibiotic Resistance Among Isolates of Klebsiella spp. and Raoultella spp. in Wildlife and Their Environment from Portugal: A Positive Epidemiologic Outcome.
The study identified a single multidrug-resistant (MDR) and extended-spectrum beta-lactamase (ESBL)-producing K. pneumoniae isolate from soil samples carrying multiple resistance genes, including bla CTX-M-15, bla TEM-1, bla SHV-28, bla OXA-1, qnr B1, oqx A, oqx B19, aac (6′)-Ibcr, sul 2, dfr A14, tet A, aph (6)-Id, aph (3″)-Ib, acr D, cat B3, and Int I1.
Protozoa-enhanced conjugation frequency alters the dissemination of soil antibiotic resistance.
Protozoa enhance the conjugation frequency of antibiotic resistance genes (ARGs) in soil microbial communities, increasing the transfer of ARGs such as blaTEM and tetA. This process is linked to increased reactive oxygen species (ROS) production and membrane permeability.
Characterization of extended-spectrum beta-lactamase-producing Enterobacteriaceae from recreational water in Athens, GA, using an undergraduate laboratory module.
The study characterized the presence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in recreational water samples from Athens, GA, focusing on the detection of bla CTX-M, bla TEM, and bla CMY-2 genes using PCR.
Salmonella and Yersinia enterocolitica through the pig meat chain in Sardinia: occurrence, antimicrobial resistance and genetic insight.
The study identified AMR genes blaTEM-1B, sul2, aph(3')-Ib, and tet(B) in Salmonella Typhimurium ST34 isolates, and blaA in Yersinia enterocolitica biotype 2 isolates, indicating resistance to various antibiotics.
Capture of mobile genetic elements following intercellular conjugation promotes the production of ST11-KL64 CR-hvKP.
The study characterizes the AMR genes and mutations involved in the conjugation process between hvKP and CRKP strains, highlighting the role of mobile genetic elements in the emergence of ST11-KL64 CR-hvKP strains.
Molecular characterization of uropathogenic Escherichia coli (UPEC) strains isolated from companion dogs and cats in Korea.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including blaTEM-1, blaCTX-M-15, blaCTX-M-55, blaCTX-M-14, blaCTX-M-27, blaCMY-2, blaCMY-2-like, blaCMY-42, blaCMY-102, and blaNDM-5, in UPEC strains from companion dogs and cats in Korea. These genes conferred resistance to various beta-lactam antibiotics such as ampicillin, cefotaxime, and cefoxitin.
Prevalence of β-lactam antibiotic resistance of Escherichia coli isolated from a neonatal intensive care unit.
The study identified several β-lactam resistance genes, including bla KPC-2, bla CTX-M-64, bla CTX-M-65, bla TEM-1, bla OXA-1, and bla DHA-1, in Escherichia coli isolates from a neonatal intensive care unit. These genes were found to confer resistance to various β-lactam antibiotics.
Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from retail markets in Yichun city, China, including genes conferring resistance to various antibiotics such as chloramphenicol, tetracycline, trimethoprim, and extended-spectrum beta-lactamases.
Occurrence of "under-the-radar" antibiotic resistance in anthropogenically affected produce.
The study identifies several clinically relevant AMR genes, including beta-lactamases (bla CTX-M, bla TEM, bla SHV, bla VIM-1), aminoglycoside resistance genes (aadA5, dfrA17, mph(A)), quinolone resistance gene (qnrS1), and sulfonamide resistance gene (sul1), which were found in anthropogenically affected lettuce samples. These genes were associated with multidrug-resistant (MDR) Enterobacteriaceae and were capable of horizontal gene transfer.
Prevalence and antibiotic resistance of Escherichia coli in urban and peri-urban garden ecosystems in Bangladesh.
The study identified the presence of blaTEM and tetA genes in E. coli isolates from urban and peri-urban gardens in Bangladesh, contributing to their resistance to ampicillin and tetracycline, respectively.
Soil warming increases the active antibiotic resistome in the gut of invasive giant African snails.
Soil warming significantly increased the abundance and activity of beta-lactamase genes such as SHV, TEM, OCH, OKP, and LEN in the gut microbiome of giant African snails, contributing to increased antibiotic resistance.
Bayesian phylogeographic analysis infers cross-border transmission dynamics of drug-resistant Salmonella Enteritidis.
The study identifies multiple antimicrobial resistance genes in Salmonella Enteritidis isolates from various regions, highlighting the cross-border transmission of drug-resistant strains and the significance of international food trade in spreading antimicrobial resistance.
Bayesian phylogeographic analysis infers cross-border transmission dynamics of drug-resistant Salmonella Enteritidis.
The study identifies multiple antimicrobial resistance genes in Salmonella Enteritidis isolates from various regions, highlighting the cross-border transmission of drug-resistant strains and the significance of international food trade in spreading antimicrobial resistance.
Bayesian phylogeographic analysis infers cross-border transmission dynamics of drug-resistant Salmonella Enteritidis.
The study identifies multiple antimicrobial resistance genes in Salmonella Enteritidis isolates from various regions, highlighting the cross-border transmission of drug-resistant strains and the significance of international food trade in spreading antimicrobial resistance.
Bayesian phylogeographic analysis infers cross-border transmission dynamics of drug-resistant Salmonella Enteritidis.
The study identifies multiple antimicrobial resistance genes in Salmonella Enteritidis isolates from various regions, highlighting the cross-border transmission of drug-resistant strains and the significance of international food trade in spreading antimicrobial resistance.
Bayesian phylogeographic analysis infers cross-border transmission dynamics of drug-resistant Salmonella Enteritidis.
The study identifies multiple antimicrobial resistance genes in Salmonella Enteritidis isolates from various regions, highlighting the cross-border transmission of drug-resistant strains and the significance of international food trade in spreading antimicrobial resistance.
Bayesian phylogeographic analysis infers cross-border transmission dynamics of drug-resistant Salmonella Enteritidis.
The study identifies multiple antimicrobial resistance genes in Salmonella Enteritidis isolates from various regions, highlighting the cross-border transmission of drug-resistant strains and the significance of international food trade in spreading antimicrobial resistance.
Bayesian phylogeographic analysis infers cross-border transmission dynamics of drug-resistant Salmonella Enteritidis.
The study identifies multiple antimicrobial resistance genes in Salmonella Enteritidis isolates from various regions, highlighting the cross-border transmission of drug-resistant strains and the significance of international food trade in spreading antimicrobial resistance.
Bayesian phylogeographic analysis infers cross-border transmission dynamics of drug-resistant Salmonella Enteritidis.
The study identifies multiple antimicrobial resistance genes in Salmonella Enteritidis isolates from various regions, highlighting the cross-border transmission of drug-resistant strains and the significance of international food trade in spreading antimicrobial resistance.
Bayesian phylogeographic analysis infers cross-border transmission dynamics of drug-resistant Salmonella Enteritidis.
The study identifies multiple antimicrobial resistance genes in Salmonella Enteritidis isolates from various regions, highlighting the cross-border transmission of drug-resistant strains and the significance of international food trade in spreading antimicrobial resistance.
Bayesian phylogeographic analysis infers cross-border transmission dynamics of drug-resistant Salmonella Enteritidis.
The study identifies multiple antimicrobial resistance genes in Salmonella Enteritidis isolates from various regions, highlighting the cross-border transmission of drug-resistant strains and the significance of international food trade in spreading antimicrobial resistance.
Bayesian phylogeographic analysis infers cross-border transmission dynamics of drug-resistant Salmonella Enteritidis.
The study identifies multiple antimicrobial resistance genes in Salmonella Enteritidis isolates from various regions, highlighting the cross-border transmission of drug-resistant strains and the significance of international food trade in spreading antimicrobial resistance.
Genomic analysis of Enterobacter cloacae complex from Southern Thailand reveals insights into multidrug resistance genotypes and genetic diversity.
The study identified multiple antimicrobial resistance genes in Enterobacter cloacae complex isolates from Southern Thailand, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and efflux pumps. Notably, the mcr-9 gene was found to confer colistin resistance.
Phylogenetic analysis blaTEM gene of Escherichia coli isolated from cave bats in West Nusa Tenggara Province, Indonesia.
The study identifies the blaTEM gene as the ESBL encoding gene in E. coli isolates from cave bats in West Nusa Tenggara, Indonesia, showing genetic closeness to E. coli strains from Thailand.
The impact of aztreonam-clavulanic acid exposure on gene expression and mutant selection using a multidrug-resistant E. coli.
The study identifies several beta-lactamase genes, including blaNDM-13, blaTEM-1B, blaTEM-141, blaCTX-M-55, and blaOXA-1, which confer resistance to aztreonam in the multidrug-resistant E. coli strain ymmD45. The aztreonam-clavulanic acid combination showed synergistic effects in reducing the MIC of aztreonam below its clinical breakpoint.
The impact of aztreonam-clavulanic acid exposure on gene expression and mutant selection using a multidrug-resistant E. coli.
The study identifies several beta-lactamase genes, including blaNDM-13, blaTEM-1B, blaTEM-141, blaCTX-M-55, and blaOXA-1, which confer resistance to aztreonam in the multidrug-resistant E. coli strain ymmD45. The aztreonam-clavulanic acid combination showed synergistic effects in reducing the MIC of aztreonam below its clinical breakpoint.
Tracing the evolution: the rise of Salmonella Thompson co-resistant to clinically important antibiotics in China, 1997-2020.
The study identifies the IncC plasmid as a major driver of co-resistance to ciprofloxacin, cefotaxime, and azithromycin in Salmonella Thompson isolates in China, with specific resistance genes including qnrS1, qepA4, blaCMY-2, and mph(A).
Small Molecules from Medicinal Plant Iris tectorum as Histidine Kinase Inhibitor to Resensitize β-Lactam-Resistant Escherichia coli.
Iris tectorum extract resensitized β-lactam-resistant E. coli by downregulating ESBL gene expression and reducing histidine kinase phosphorylation levels.
Acinetobacter baumannii infection in critically ill patients with COVID-19 from Tehran, Iran: the prevalence, antimicrobial resistance patterns and molecular characteristics of isolates.
The study identified multiple antimicrobial resistance genes in Acinetobacter baumannii isolates from COVID-19 patients, including aac(6')-Ib, aac(3)-Ia, ant(2")-Ia, aph(3')-Ia, blaTEM, blaNDM, blaOXA-23-like, and blaOXA-24-like. These genes conferred resistance to various antibiotics, highlighting the challenge of treating multidrug-resistant infections.
Genomic epidemiology and antimicrobial resistance of Morganella clinical isolates between 2016 and 2023.
The study identified several AMR genes in Morganella clinical isolates, including tet(B), sul1, catA2, sul2, floR, aadA1, and others, contributing to resistance against various antibiotics.
Phenotypic and genotypic characterization of Aeromonas hydrophila isolated from freshwater fishes at Middle Upper Egypt.
The study identified the presence of blaTEM, qnrA, sul1, and tetA genes in multidrug-resistant Aeromonas hydrophila isolates from freshwater fishes in Middle Upper Egypt, highlighting the significance of these genes in antimicrobial resistance.
Comprehensive genomic insights into a highly pathogenic clone ST656 of mcr8.1 containing multidrug-resistant Klebsiella pneumoniae from Bangladesh.
The study identifies multiple beta-lactamase genes (blaLAP-2, blaTEM-1, blaSHV-11, blaOXA-1) and the mcr8.1 gene, which confers resistance to colistin, in a multidrug-resistant K. pneumoniae ST656 isolate from Bangladesh. Additionally, the qacEdelta1 gene, which contributes to resistance against disinfectants and antibiotics, was detected.
Genomic insights into plasmid mediated AMR genes, virulence factors and mobile genetic elements in raw milk Escherichia coli from Gujarat, India.
The study identified multiple antibiotic resistance genes in E. coli isolates from raw milk in Gujarat, India, including beta-lactamases, quinolone resistance genes, efflux pumps, folate pathway antagonists, aminoglycoside resistance genes, and tetracycline resistance genes.
Machine Learning-Based Detection of Heteroresistance to Piperacillin/Tazobactam in Escherichia coli
The study identifies beta-lactamase genes (blaTEM, blaCTX, blaSHV, ampC) as strong predictors of heteroresistance in E. coli, with the number of these genes correlating with resistance levels.
Eradication of Helicobacter pylori reshapes gut microbiota and facilitates the evolution of antimicrobial resistance through gene transfer and genomic mutations in the gut.
H. pylori eradication led to the enrichment of various AMR genes, including beta-lactamases, macrolide phosphotransferases, erythromycin ribosome methyltransferases, sulfonamide resistance proteins, tetracycline efflux pumps, dihydrofolate reductase, quaternary ammonium compound efflux pumps, and aminoglycoside phosphotransferases. Additionally, genomic mutations in parC, parE, and gyrA were associated with fluoroquinolone resistance in E. coli.
Eradication of Helicobacter pylori reshapes gut microbiota and facilitates the evolution of antimicrobial resistance through gene transfer and genomic mutations in the gut.
H. pylori eradication led to the enrichment of various AMR genes, including beta-lactamases, macrolide phosphotransferases, erythromycin ribosome methyltransferases, sulfonamide resistance proteins, tetracycline efflux pumps, dihydrofolate reductase, quaternary ammonium compound efflux pumps, and aminoglycoside phosphotransferases. Additionally, genomic mutations in parC, parE, and gyrA were associated with fluoroquinolone resistance in E. coli.
Eradication of Helicobacter pylori reshapes gut microbiota and facilitates the evolution of antimicrobial resistance through gene transfer and genomic mutations in the gut.
H. pylori eradication led to the enrichment of various AMR genes, including beta-lactamases, macrolide phosphotransferases, erythromycin ribosome methyltransferases, sulfonamide resistance proteins, tetracycline efflux pumps, dihydrofolate reductase, quaternary ammonium compound efflux pumps, and aminoglycoside phosphotransferases. Additionally, genomic mutations in parC, parE, and gyrA were associated with fluoroquinolone resistance in E. coli.
Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.
This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.
Molecular epidemiology of Escherichia coli in bloodstream infections from a general hospital in Ningxia, China, 2022-2023.
The study identified bla CTX-M as the predominant ESBL gene and aac(6')-Ib-cr as the main quinolone resistance gene in E. coli causing bloodstream infections. Mutations in gyrA and parC were associated with quinolone resistance.
Epidemic trend of Salmonella from swines and broilers in China from 2014 to 2023 and genetic evolution analysis of ESBLs-producing strains.
The study identified several AMR genes in ESBL-producing Salmonella strains from swines and broilers in China, including blaCTX-M-14, blaTEM-1B, blaCTX-M-65, aac(6')-Iaa, floR, sul2, tet(B), arr-2, fosA3, dfrA12, mph(A), lnu(F), blaCTX-M-55, blaOXA-1, sul1, tet(A), catB3, qnrS1, and mcr-1.1. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, sulfonamides, tetracyclines, rifampicin, fosfomycin, trimethoprim, macrolides, lincomycin, quinolones, and colistin.
Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
The study identified various AMR genes and mutations in Salmonella Enteritidis isolates from Spain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and aminoglycoside resistance genes. Chromosomal mutations in the gyrA gene were also found to contribute to quinolone resistance.
Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
The study identified various AMR genes and mutations in Salmonella Enteritidis isolates from Spain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and aminoglycoside resistance genes. Chromosomal mutations in the gyrA gene were also found to contribute to quinolone resistance.
Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
The study identified various AMR genes and mutations in Salmonella Enteritidis isolates from Spain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and aminoglycoside resistance genes. Chromosomal mutations in the gyrA gene were also found to contribute to quinolone resistance.
Avian-specific Salmonella transition to endemicity is accompanied by localized resistome and mobilome interaction.
The study identifies several antimicrobial resistance genes, including bla TEM-1B, sul2, and tet(A), which are prevalent in Salmonella enterica serovar Gallinarum isolates. These genes contribute to the resistome diversity and are associated with specific lineages and geographical regions.
Drug resistance and genotyping studies of Salmonella Enteritidis isolated from broiler chickens in Iran.
The study identified several AMR genes in Salmonella Enteritidis isolates from broiler chickens in Iran, including bla TEM, tet A, tet B, sul 1, and str A/B, which conferred resistance to various antibiotics.
Preliminary survey of biofilm forming, antibiotic resistant Escherichia coli in fishes from land based aquaculture systems and open water bodies in Bangladesh.
The study identified several antibiotic resistance genes, including blaTEM, blaSHV, blaCTX, sul1, and the biofilm-forming gene fimC, in Escherichia coli isolates from both wild and cultured fish in Bangladesh.
Microplastics enhance the prevalence of antibiotic resistance genes in mariculture sediments by enriching host bacteria and promoting horizontal gene transfer.
Microplastics enhance the prevalence of antibiotic resistance genes in mariculture sediments by enriching host bacteria and promoting horizontal gene transfer.
Detection of a genetically related carbapenemase-producing Escherichia coli ST167 in clinical and environmental isolates: Evidence for clonal spread of carbapenemase-producing Enterobacteriaceae in humans and the environment in Iowa, United States.
The study identifies a carbapenemase-producing E. coli strain BO1 carrying bla NDM-5, along with other resistance genes, highlighting the clonal spread of carbapenemase-producing Enterobacteriaceae between humans and the environment in Iowa.
Genomic insights into extended-spectrum beta-lactamase- and plasmid-borne AmpC-producing Escherichia coli transmission between humans and livestock in rural Cambodia.
The study identifies a wide range of AMR genes, including bla CTX-M, bla TEM, tet(A), sul2, aph(3'')-Ib, aac(6')-Ib-cr, qnrS1, lnu(F), mph(A), and mcr-1.1, in ESC-Ec strains from humans and livestock in rural Cambodia, highlighting the transmission of these genes between hosts.
Molecular detection of blaTEM-encoding genes in multidrug-resistant Escherichia coli from cloacal swabs of ducks in Indonesia farms.
The study detected blaTEM-encoding genes in multidrug-resistant Escherichia coli from cloacal swabs of ducks in Indonesia, highlighting the presence of extended-spectrum beta-lactamase-producing bacteria in poultry, which poses a public health concern.
Whole-Genome Sequencing of Extended-Spectrum beta-lactamase-Producing Klebsiella pneumoniae Isolated from Human Bloodstream Infections.
The study identified multiple AMR genes in ESBL-producing K. pneumoniae isolates, including blaCTX-M-15, blaKPC-3, and others conferring resistance to β-lactams, aminoglycosides, fluoroquinolones, sulfonamides, tetracyclines, and chloramphenicol.
Zoonotic potential of uropathogenic Escherichia coli lineages from companion animals.
The study identified several antimicrobial resistance genes in uropathogenic E. coli strains from companion animals, including blaTEM-1b, sul1, sul2, dfrA1_10, dfrA17_1, dfrA1_8, dfrA7_5, gyrA_S83L, tetA, tetB, aph(6)-Id, aph(3'')-Ib, ant(3'')-Ia, blaCTX-M-15, blaTEM-106, blaSHV-102, and blaCMY-2. These genes confer resistance to various antibiotics such as penicillins, sulfonamides, trimethoprim, quinolones, tetracyclines, streptomycin, and cephalosporins.
Zoonotic potential of uropathogenic Escherichia coli lineages from companion animals.
The study identified several antimicrobial resistance genes in uropathogenic E. coli strains from companion animals, including blaTEM-1b, sul1, sul2, dfrA1_10, dfrA17_1, dfrA1_8, dfrA7_5, gyrA_S83L, tetA, tetB, aph(6)-Id, aph(3'')-Ib, ant(3'')-Ia, blaCTX-M-15, blaTEM-106, blaSHV-102, and blaCMY-2. These genes confer resistance to various antibiotics such as penicillins, sulfonamides, trimethoprim, quinolones, tetracyclines, streptomycin, and cephalosporins.
Mechanisms of Salmonella typhimurium Resistance to Cannabidiol.
The study identified blaTEM, fimA, fimZ, STM0959, STM0716, and spy genes as key contributors to Salmonella typhimurium resistance to cannabidiol (CBD).
A Snapshot of Antimicrobial Resistance in Semi-Wild Oryx: Baseline Data from Qatar.
The study identified tetracycline resistance genes tetA and tetB, as well as bla CTX-M and bla TEM-1 for beta-lactam resistance in E. coli isolates from semi-wild oryx in Qatar. Whole genome sequencing revealed additional resistance mechanisms, including mutations in soxR associated with tetracycline resistance.
Prevalence, antibiotic resistance, virulence and antimicrobial resistance gene profiles of Salmonella species recovered from retail beef and poultry processing environments.
The study identified the presence of resistance genes bla TEM, tetA, and sul1 in Salmonella isolates from retail beef and poultry processing environments, indicating high levels of antimicrobial resistance.
Strict relationship between phenotypic and plasmid-associated genotypic of multidrug-resistant Escherichia coli isolated from Taihe Black-Boned Silky Fowl farms.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from Taihe Black-Boned Silky Fowl farms, including blaTEM, blaOXA-10, tetA, tetR, floR, cmlA, qnrS, strA, strB, aadA, aac(3)-IId, sul, and dfrA. These genes were associated with resistance to beta-lactams, tetracyclines, chloramphenicol, fluoroquinolones, aminoglycosides, and sulfonamides.
Polyclonal carbapenemase-producing Escherichia coli in Northern Italy: the emergence of NDM-7.
The study identifies the emergence of NDM-7 in polyclonal carbapenemase-producing E. coli in Northern Italy, highlighting the presence of various carbapenemase genes such as bla KPC-3, bla VIM-1, and bla NDM-7, along with other resistance genes.
The Study of Escherichia coli as Antimicrobial-Resistant Sentinel Microorganism Isolated in the Farms of Three Districts of Ankara by MALDI-TOF MS and Genomic Analysis.
The study identified the presence of ESBL genes CTX-M-14 and TEM-1 in an ESBL-positive E. coli isolate, along with other resistance genes such as aadA2, APH(3'')-Ib, APH(6)-Id, tet(A), tet(B), and sul1, sul2, sul3.
Genomic features, antimicrobial resistance and pathogenicity assessment of Escherichia coli serotype O177:H51 strain JS01 isolated from a diseased chicken.
The study identified 64 AMR genes and 177 virulence factor genes in the E. coli strain JS01, highlighting its multidrug resistance and high pathogenicity.
Whole-genome-based characterization of Escherichia albertii strains isolated from paediatric diarrhoeal cases in Kolkata, India.
The study identified several antimicrobial resistance genes in Escherichia albertii isolates, including beta-lactamases (bla CTX-M-55, bla TEM-105), quinolone resistance genes (qnrS1, qnrB32), sulfonamide resistance gene (sul2), tetracycline resistance genes (tetA, tetR), and trimethoprim resistance gene (dfrA1).
Role of lactoferrin in the treatment of E. coli-induced bovine mastitis.
The study identified BlaTEM, aadB, and Sul1 as the resistance genes in E. coli isolates from bovine mastitis cases, with all isolates showing resistance to gentamycin, ampicillin, cefquinome, cefixime, and sulfamethoxazole-trimethoprim.
Extended-spectrum β-lactamase-producing Escherichia coli isolated from captive primates: characteristics and horizontal gene transfer ability analysis.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-55, bla CTX-M-15, bla TEM-1, bla TEM-135, and bla TEM-198, in ESBL-producing E. coli isolates from captive primates. These genes confer resistance to beta-lactam antibiotics, and the isolates also carried mobile genetic elements (MGEs) and virulence-associated genes (VAGs).
Extended-spectrum β-lactamase-producing Escherichia coli isolated from captive primates: characteristics and horizontal gene transfer ability analysis.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-55, bla CTX-M-15, bla TEM-1, bla TEM-135, and bla TEM-198, in ESBL-producing E. coli isolates from captive primates. These genes confer resistance to beta-lactam antibiotics, and the isolates also carried mobile genetic elements (MGEs) and virulence-associated genes (VAGs).
Extended-spectrum β-lactamase-producing Escherichia coli isolated from captive primates: characteristics and horizontal gene transfer ability analysis.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-55, bla CTX-M-15, bla TEM-1, bla TEM-135, and bla TEM-198, in ESBL-producing E. coli isolates from captive primates. These genes confer resistance to beta-lactam antibiotics, and the isolates also carried mobile genetic elements (MGEs) and virulence-associated genes (VAGs).
Genomic analyses reveal presence of extensively drug-resistant Salmonella enterica serovars isolated from clinical samples in Guizhou province, China, 2019-2023.
The study identified multiple antimicrobial resistance genes and mutations in XDR Salmonella isolates from Guizhou, China, including bla TEM-1, bla CTX-M-55, qnrS1, oqxA, aac(6')-Ib-cr, tetA, mcr-1.1, and bla NDM-1, as well as mutations in gyrA and parC associated with fluoroquinolone resistance.
Characterization of phenotypic and genotypic traits of Klebsiella pneumoniae strains resistant to 3rd generation cephalosporins in hospital settings: A case study in Ho Chi Minh City, Vietnam.
The study identifies the prevalence of AmpC beta-lactamase, ESBL, and carbapenemase genes in Klebsiella pneumoniae isolates from Ho Chi Minh City, Vietnam, highlighting the high resistance rates to third-generation cephalosporins and carbapenems.
Inhibitory effects of benzyl isothiocyanate on widespread mcr-1-harbouring IncX4 plasmid transfer.
The study characterizes the presence of mcr-1.1, mcr-3.5, blaCTX-M-55, and tet(X4) genes in clinical isolates of Enterobacterales from Thailand, highlighting their role in multidrug resistance and the potential for horizontal gene transfer.
Development of a PCR-dipstick DNA chromatography-based tool for the detection of CTX-M- and TEM-producing Escherichia coli and Klebsiella pneumoniae isolated from patients in Kafue and Katete districts of Zambia.
The study identified bla CTX-M and bla TEM genes as the primary contributors to third-generation cephalosporin resistance in Escherichia coli and Klebsiella pneumoniae isolates from Zambia. A PCR-dipstick DNA chromatography-based tool was developed for their detection.
Extended spectrum beta-lactamase producing Escherichia coli and antimicrobial resistance gene sharing at the interface of human, poultry and environment: results of ESBL tricycle surveillance in Kathmandu, Nepal.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla CTX-M-27, bla CTX-M-14, bla CMY-148, bla CMY-2, bla CMY-4, bla DHA-1, bla OXA-1, bla OXA-9, bla NDM-5, bla TEM-1, bla TEM-135, bla TEM-176, bla TEM-190, and the polymyxin resistance gene mcr-1 in ESBL-producing E. coli isolates from human, poultry, and environmental sources in Kathmandu, Nepal.
Extended spectrum beta-lactamase producing Escherichia coli and antimicrobial resistance gene sharing at the interface of human, poultry and environment: results of ESBL tricycle surveillance in Kathmandu, Nepal.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla CTX-M-27, bla CTX-M-14, bla CMY-148, bla CMY-2, bla CMY-4, bla DHA-1, bla OXA-1, bla OXA-9, bla NDM-5, bla TEM-1, bla TEM-135, bla TEM-176, bla TEM-190, and the polymyxin resistance gene mcr-1 in ESBL-producing E. coli isolates from human, poultry, and environmental sources in Kathmandu, Nepal.
Extended spectrum beta-lactamase producing Escherichia coli and antimicrobial resistance gene sharing at the interface of human, poultry and environment: results of ESBL tricycle surveillance in Kathmandu, Nepal.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla CTX-M-27, bla CTX-M-14, bla CMY-148, bla CMY-2, bla CMY-4, bla DHA-1, bla OXA-1, bla OXA-9, bla NDM-5, bla TEM-1, bla TEM-135, bla TEM-176, bla TEM-190, and the polymyxin resistance gene mcr-1 in ESBL-producing E. coli isolates from human, poultry, and environmental sources in Kathmandu, Nepal.
Extended spectrum beta-lactamase producing Escherichia coli and antimicrobial resistance gene sharing at the interface of human, poultry and environment: results of ESBL tricycle surveillance in Kathmandu, Nepal.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla CTX-M-27, bla CTX-M-14, bla CMY-148, bla CMY-2, bla CMY-4, bla DHA-1, bla OXA-1, bla OXA-9, bla NDM-5, bla TEM-1, bla TEM-135, bla TEM-176, bla TEM-190, and the polymyxin resistance gene mcr-1 in ESBL-producing E. coli isolates from human, poultry, and environmental sources in Kathmandu, Nepal.
Dissemination and phenotypic characterization of ESBL-producing Escherichia coli in Indonesia.
The study identified bla CTX-M, bla SHV, and bla TEM genes in ESBL-producing E. coli isolates from Indonesia, with bla CTX-M being the most prevalent. These genes confer resistance to cefotaxime and other antibiotics, highlighting the multidrug resistance of these isolates.
Isolation, Antimicrobial Susceptibility, and Genotypes of Three Pasteurellaeae Species Prevalent on Pig Farms in China Between 2021 and 2023.
The study identified 18 antimicrobial resistance genes in three Pasteurellaeae species, including tetracycline, beta-lactam, sulfonamide, aminoglycoside, and macrolide resistance genes. High frequencies of tet(L), tet(M), tet(A), blaTEM, sul2, aph(3')-Ia, dfrA12, qnrS1, strA, sul3, and mef(B) were observed.
Identification of pandemic ST147, ESBL-type beta-lactamases, carbapenemases, and virulence factors in Klebsiella pneumoniae isolated from southern Peru.
The study identified ESBL genes (blaCTX-M, blaTEM, blaSHV) and carbapenemase genes (blaKPC-2, blaNDM-1) in K. pneumoniae isolates from Cusco, Peru. Additionally, aminoglycoside resistance genes (aadA1, aph(3')-Ib) and mutations in porin-coding genes (ompK36) and gyrA were found, contributing to multidrug resistance.
Molecular and Epidemiological Characterization of ESBL-producing Escherichia coli from Captive Wild Birds in Zoological Gardens in Nigeria.
The study identified ESBL-producing E. coli isolates from captive wild birds in Nigerian zoological gardens, highlighting the prevalence of bla CTX-M, bla SHV, and bla TEM genes, which confer resistance to beta-lactam antibiotics.
Molecular Characterization of Extended-Spectrum ß-Lactamases-Producing Escherichia coli Isolated from a Greek Food Testing Laboratory.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla SHV-12, and bla TEM-1B, in Escherichia coli isolates from food of animal origin in Greece. These genes were associated with resistance to third-generation cephalosporins and other beta-lactam antibiotics.
Extended-Spectrum-Beta-Lactamase (ESBL)-Producing Escherichia coli in Laying Hens: Slaughterhouse Prevalence and Antibiotic Resistance Patterns.
The study identified bla CTX-M, bla TEM, bla SHV, and bla OXA genes in ESBL-producing E. coli isolates from laying hen slaughterhouses, which conferred resistance to multiple beta-lactam antibiotics.
Identification of a Potential High-Risk Clone and Novel Sequence Type of Carbapenem-Resistant Pseudomonas aeruginosa in Metro Manila, Philippines.
The study identifies OprD mutations as a significant mechanism of carbapenem resistance in Pseudomonas aeruginosa isolates from the Philippines, highlighting the importance of porin dysfunction in resistance development.
Antimicrobial Resistance Patterns of ESBL-Producing Escherichia coli in Dogs from Thailand: Evaluation of Algal Extracts as Novel Antimicrobial Agents.
The study identified bla TEM, bla CTX-M, and bla SHV as the primary beta-lactamase genes responsible for antimicrobial resistance in ESBL-producing E. coli isolates from dogs in Thailand.
Intestinal and Extraintestinal Pathotypes of Escherichia coli Are Prevalent in Food Prepared and Marketed on the Streets from the Central Zone of Mexico and Exhibit a Differential Phenotype of Resistance Against Antibiotics.
The study identifies multiple antibiotic resistance genes in E. coli isolates from street-prepared food in Mexico, including strA, sul1, catA1, floR, qnrS, and tetA, which confer resistance to streptomycin, sulfonamides, chloramphenicol, quinolones, and tetracycline.
First report of multidrug-resistant and pathogenic Plesiomonas shigelloides from endangered crested ibis (Nipponia nippon).
The study reports the first isolation of multidrug-resistant and pathogenic Plesiomonas shigelloides from the endangered crested ibis, highlighting the presence of resistance genes such as blaTEM, aac(6')-Ib3, aac(6')-Ib-cr, mph(A), arr-2, tet(A), qacEΔ1, dfrA1, and sulI.
Genome-Based Molecular Diversity of Extended-Spectrum beta-lactamase-Producing Escherichia coli From Pigeons in China.
The study identifies multiple extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M, bla TEM, bla OXA, bla LAP, and bla CMY, as well as other antibiotic resistance genes such as mcr-1, mcr-1.1, tet(X4), aadA1, aadA2, aph(6)-Id, aph(3")-Ib, aph(3')-Ia, aph(3')-IIa, aac(3)-IVa, aph(4)-Ia, tet(A), tet(M), sul2, sul3, dfrA14, qnrS1, arr-2, fosA3, cmlA5, floR, mph(A), and lnu(F) in ESBL-producing E. coli isolates from pigeons in China.
Identification and Genomic Analyses of a Multidrug Resistant Avian Pathogenic Escherichia coli Coharboring mcr-1, bla (TEM-176) and bla (CTX-M-14) Genes.
The study identified a multidrug-resistant APEC isolate carrying mcr-1, bla(CTX-M-14), and bla(TEM-176) genes, which conferred resistance to polymyxin B and third-generation cephalosporins.
Plasmid-Mediated Co-Occurrence of mcr-1.1 in Extended-Spectrum beta-lactamase (ESBL)-Producing Escherichia coli Isolated From the Indigenous Seminomadic Community in Malaysia.
The study identifies the presence of mcr-1.1, bla TEM, bla CTX-M−15, bla CTX-M−55, and other resistance genes in ESBL-producing E. coli isolates from the Jehai community in Malaysia, highlighting the co-occurrence of multiple antibiotic resistance mechanisms.
Wild Birds as Drivers of Salmonella Braenderup and Multidrug Resistant Bacteria in Wetlands of Northern Italy.
The study identifies several AMR genes in bacterial isolates from wild aquatic birds in Northern Italy, including beta-lactamases (blaTEM, blaCMY-1, blaCMY-2, blaNDM, blaKPC), colistin resistance genes (mcr-2, mcr-3, mcr-4), tetracycline resistance genes (tetA, tetB, tetC, tetL, tetM, tetK), macrolide resistance genes (ermB, vatD, vgA, msrC), vancomycin resistance genes (vanC1, vanC2, vanM, vanG), sulfonamide resistance genes (sul1, sul2, sul3), aminoglycoside resistance genes (aac(3), aac(6')-Ib, aph(3')-Ia, armA, rmtB, rmtC, rmtF), and nitrofurantoin resistance genes (nfsA, nfsB).
Contaminated drinking water facilitates Escherichia coli strain-sharing within households in urban informal settlements.
The study identified several clinically relevant antibiotic resistance genes (ARGs) in Escherichia coli strains from various sources, including poultry, humans, dogs, soil, and stored drinking water. Notably, bla TEM-1 and bla CTX-M-15 were widely detected, indicating the spread of beta-lactam resistance. Additionally, aph(6)-Id, which confers aminoglycoside resistance, was commonly found in canine samples.
Origin, evolution, and success of pbla, the gonococcal beta-lactamase plasmid, and implications for public health.
The study identifies TEM-135 as a beta-lactamase variant that confers increased penicillin resistance in Neisseria gonorrhoeae, contributing to the success of p bla plasmid variants.
Origin, evolution, and success of pbla, the gonococcal beta-lactamase plasmid, and implications for public health.
The study identifies TEM-135 as a beta-lactamase variant that confers increased penicillin resistance in Neisseria gonorrhoeae, contributing to the success of p bla plasmid variants.
Shelter dogs as reservoirs of international clones of Escherichia coli carrying mcr-1.1 and bla(CTX-M) resistance genes in Lima, Peru.
The study identifies mcr-1.1 and bla CTX-M resistance genes in E. coli isolates from shelter dogs in Lima, Peru, highlighting their role as reservoirs of multidrug-resistant bacteria.
Presence of microplastic particles increased abundance of pathogens and antimicrobial resistance genes in microbial communities from the Oder river water and sediment.
The study identified several antimicrobial resistance (AMR) genes in microbial communities from the Oder river water and sediment, including blaTEM-116, erm(F), otr(C), ole(C), oqxB, dfrB3, tcr3, otr(A), vat(F), mph(E), srmB, and qepA4. These genes were associated with resistance to various antibiotics such as beta-lactams, macrolides, tetracyclines, and fluoroquinolones.
Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?
The study identified multiple antibiotic resistance genes in clinical Klebsiella pneumoniae isolates, including bla TEM, bla SHV, bla CTX-M, and bla OXA families, as well as aminoglycoside, fluoroquinolone, and sulfonamide resistance genes. Effluent isolates showed fewer resistance genes and lower resistance levels compared to clinical isolates.
Third-Generation Cephalosporin-Resistant Uropathogenic Escherichia coli From Community- and Hospital-Acquired Infections Show High Level of Antibiotic Resistance and Specific Virulence Traits.
The study identifies bla CTX-M and bla TEM as dominant beta-lactamase genes in 3GC-resistant E. coli isolates from both community and hospital settings, highlighting their role in multidrug resistance.
The First Case of Antimicrobial-Resistant Salmonella Stanley ST29 Diagnosed Secondary to Acute Cholecystitis.
The study identifies multiple antimicrobial resistance genes in Salmonella Stanley ST29, including beta-lactamases, quinolone resistance genes, macrolide resistance genes, and others, contributing to resistance against various antibiotics.
Mapping Antimicrobial Resistance in Escherichia coli and Klebsiella pneumoniae from Complicated Urinary Tract Infections in Oman: Phenotypic and Genotypic Insights.
The study identified blaDHA-1 as the predominant AmpC gene in E. coli and blaOXA-232 and blaNDM-5 as the primary carbapenemases in K. pneumoniae. Additionally, various other resistance genes such as blaCTX-M-15, blaOXA-1, blaTEM-1B, qnrB4, aac(6')-Ib, and armA were characterized.
Mapping Antimicrobial Resistance in Escherichia coli and Klebsiella pneumoniae from Complicated Urinary Tract Infections in Oman: Phenotypic and Genotypic Insights.
The study identified blaDHA-1 as the predominant AmpC gene in E. coli and blaOXA-232 and blaNDM-5 as the primary carbapenemases in K. pneumoniae. Additionally, various other resistance genes such as blaCTX-M-15, blaOXA-1, blaTEM-1B, qnrB4, aac(6')-Ib, and armA were characterized.
Epidemiology and molecular characterisation of multidrug-resistant Escherichia coli isolated from chicken meat.
The study identified bla TEM and sul 2 genes as key contributors to ampicillin and sulfamethoxazole-trimethoprim resistance in multidrug-resistant E. coli isolates from chicken meat.
A novel tri-mode detection platform for ampicillin and drug resistance genes by CRISPR-driven luminescent nanozymes.
The study presents a tri-mode detection platform integrating fluorescence, colorimetric, and photothermal modalities for the simultaneous detection of ampicillin (AMP) and the blaTEM gene, which confers resistance to beta-lactam antibiotics.
Antimicrobial Resistance in Nigeria: A Comprehensive Review of Environmental, Food, and Clinical Impacts
The study identifies several AMR genes, including bla CTX-M-15, floR, and various tetracycline and sulfonamide resistance genes, highlighting the spread of multidrug-resistant bacteria in Nigeria's environment, food supply chain, and clinical settings.
Antimicrobial Resistance in Nigeria: A Comprehensive Review of Environmental, Food, and Clinical Impacts
The study identifies several AMR genes, including bla CTX-M-15, floR, and various tetracycline and sulfonamide resistance genes, highlighting the spread of multidrug-resistant bacteria in Nigeria's environment, food supply chain, and clinical settings.
Antimicrobial Resistance in Nigeria: A Comprehensive Review of Environmental, Food, and Clinical Impacts
The study identifies several AMR genes, including bla CTX-M-15, floR, and various tetracycline and sulfonamide resistance genes, highlighting the spread of multidrug-resistant bacteria in Nigeria's environment, food supply chain, and clinical settings.
ESBL/pAmpC-producing Enterobacterales in common leopard geckos (Eublepharis macularius) and central bearded dragons (Pogona vitticeps) from Portugal.
The study identified ESBL and AmpC beta-lactamase genes, including bla CMY-2, bla CTX-M-15, and bla TEM-1, in 3GC-resistant Enterobacterales from common leopard geckos and central bearded dragons in Portugal.
Molecular characterization of multidrug-resistant E. coli recovered from diarrheagenic children under 5 years from Mukuru Informal Settlement, Nairobi, Kenya, based on whole-genome sequencing analysis.
The study identified multiple AMR genes and mutations in multidrug-resistant E. coli isolates from diarrheagenic children in Nairobi, Kenya, highlighting the presence of blaTEM-1B, blaCTX-M-15, qnrS1, qnrB4, aac(6')-Ib-cr, and other resistance mechanisms.
Rapid whole genome sequencing for AMR surveillance in low- and middle-income countries: Oxford Nanopore Technology reveals multidrug-resistant Enterobacter cloacae complex from dairy farms in Sri Lanka.
The study identified multiple AMR genes in multidrug-resistant Enterobacter isolates from dairy farms in Sri Lanka, including blaCMH-1, blaACT-25, blaCTX-M-15, blaOXA-1, blaTEM-1, blaNDM-4, and blaNDM-15, highlighting the presence of carbapenem-resistant Enterobacterales and the need for improved AMR surveillance in low-resource settings.
A high-resolution genomic and phenotypic analysis of resistance evolution of an Escherichia coli strain from a critically unwell patient treated with piperacillin/tazobactam.
The study identifies the evolution of piperacillin/tazobactam resistance in an Escherichia coli isolate through the hyperproduction of TEM-1 beta-lactamase due to IS26-mediated duplication of the blaTEM-1 gene on a plasmid.
Biofilms and antibiotic resistance profile of Enterococcus faecalis in selected dairy cattle farm environments in Bangladesh.
The study identified the presence of the blaTEM and vanA genes in Enterococcus faecalis isolates from dairy cattle and farm environments in Bangladesh, indicating resistance to ampicillin and vancomycin, respectively.
Multidrug-resistant Shigella flexneri outbreak affecting humans and non-human primates in New Mexico, USA.
The study identifies multidrug-resistant Shigella flexneri serotype 2a strains in both human and non-human primate populations in New Mexico, USA, carrying resistance genes such as blaOXA-1, blaTEM-1, sul2, dfrA1, and dfrA5, along with fluoroquinolone resistance-conferring mutations in parC and gyrA.
Antimicrobial resistance and genetic diversity of Escherichia coli isolated from marine bivalves.
The study identified several AMR genes in E. coli isolates from marine bivalves, including bla TEM, bla CTX-M9, bla SHV, bla CTX-M2, bla CTX-M8/25, qnrS, qnrB, sul1, and sul2. These genes were associated with resistance to various antibiotics, highlighting the role of marine environments in the dissemination of AMR.
Whole genome sequencing reveals virulence-mobile element linkages and phylogenetic diversity in multidrug-resistant Escherichia coli from Nigeria.
The study identified multidrug-resistant Escherichia coli isolates from Nigeria, highlighting the presence of virulence genes and mobile genetic elements, along with specific mutations in gyrA and parC that confer resistance to fluoroquinolones.
Whole genome sequencing reveals virulence-mobile element linkages and phylogenetic diversity in multidrug-resistant Escherichia coli from Nigeria.
The study identified multidrug-resistant Escherichia coli isolates from Nigeria, highlighting the presence of virulence genes and mobile genetic elements, along with specific mutations in gyrA and parC that confer resistance to fluoroquinolones.
Transmissible antimicrobial resistance in Escherichia coli isolated from household drinking water in Ibadan, Nigeria.
The study identified several AMR genes in E. coli isolates from household water in Ibadan, Nigeria, including blaTEM-1B, dfrA14, tetA, qnrS1, and mcr-1, highlighting the potential for horizontal gene transfer and the risk of AMR spread in the environment.
Molecular characterization of multidrug-resistant Escherichia coli in the Greater Accra Region, Ghana: a 'One Health' approach.
The study identified multidrug-resistant Escherichia coli isolates carrying various AMR genes, including blaTEM-1B, tetA, sul2, aph(3'')-Id, dfrA14, qnrS1, and blaCTX-M-15, highlighting the spread of resistance mechanisms in the Greater Accra Region.
Escherichia coli causing bloodstream infections in Mexican paediatric patients: molecular typing, antimicrobial resistance, virulence factors, and clinical features.
The study identified CTX-M-type ESBLs as the main mediators of resistance to 3GCs and 4GCs in E. coli isolates causing bloodstream infections in Mexican paediatric patients. The aac(6')-Ib-cr gene was also detected, contributing to aminoglycoside resistance.
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
The study identified multiple antibiotic resistance genes and mutations in E. coli isolates from intensive pig farming in South Africa, highlighting the spread of resistance across the pork production continuum.
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
The study identified multiple antibiotic resistance genes and mutations in E. coli isolates from intensive pig farming in South Africa, highlighting the spread of resistance across the pork production continuum.
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
The study identified multiple antibiotic resistance genes and mutations in E. coli isolates from intensive pig farming in South Africa, highlighting the spread of resistance across the pork production continuum.
Molecular Detection of Antibiotic Resistance Genes Using Respiratory Sample from Pneumonia Patients.
The study identified several antibiotic resistance genes in respiratory samples from pneumonia patients, including MecA, Tem, Oxa-48-like, Ctx-M-1, Oxa-51-like, VanA, Shv, and Ndm, which are associated with resistance to methicillin, beta-lactam antibiotics, carbapenems, and vancomycin.
Unravelling the Persistence of the Rare Serovar Salmonella Mikawasima in a Hospital Setting: A Whole-Genome Sequencing Study.
The study identifies aminoglycoside resistance genes (aac(6')-Iaa, aac(6')-Im, aph(2")-Ib), beta-lactamase genes (bla TEM-1B, bla SHV-2), and the tetracycline resistance gene tet(D) in Salmonella Mikawasima isolates, highlighting multidrug resistance in hospital settings.
A Multidrug-Resistant Escherichia coli Caused the Death of the Chinese Soft-Shelled Turtle (Pelodiscus sinensis).
The study identifies a multidrug-resistant E. coli strain (HD-593) isolated from diseased Chinese soft-shelled turtles, which exhibits resistance to 14 antibiotics and carries several resistance genes including quinolone, aminoglycoside, beta-lactam, and acylaminol resistance genes.
Dogs fed raw meat-based diets are vectors of drug-resistant Salmonella infection in humans.
Nationwide surveillance of carbapenem-resistant Gram-negative pathogens in the Lebanese environment.
The study identified carbapenem-resistant Gram-negative bacteria in various environmental samples in Lebanon, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Key resistance genes detected include bla NDM-5, bla OXA-23, bla OXA-66, mexAB-OprM, bla IMP-1, and others, highlighting the widespread presence of carbapenem resistance in the environment.
Genomic insights into antibiotic-resistant non-typhoidal Salmonella isolates from outpatients in Minhang District in Shanghai.
The study identifies multiple antibiotic resistance genes and mutations in non-typhoidal Salmonella isolates from Minhang District, Shanghai, highlighting the prevalence of multidrug-resistant strains and the role of specific genetic elements in resistance mechanisms.
Prevalence of ESBL-producing Escherichia coli in sub-Saharan Africa: A meta-analysis using a One Health approach.
The study identifies bla CTX-M-15 as the most frequently reported ESBL gene in sub-Saharan Africa, along with various other bla CTX-M, bla TEM, bla SHV, and bla OXA variants. These genes confer resistance to multiple beta-lactam antibiotics.
Prevalence of ESBL-producing Escherichia coli in sub-Saharan Africa: A meta-analysis using a One Health approach.
The study identifies bla CTX-M-15 as the most frequently reported ESBL gene in sub-Saharan Africa, along with various other bla CTX-M, bla TEM, bla SHV, and bla OXA variants. These genes confer resistance to multiple beta-lactam antibiotics.
Prevalence of ESBL-producing Escherichia coli in sub-Saharan Africa: A meta-analysis using a One Health approach.
The study identifies bla CTX-M-15 as the most frequently reported ESBL gene in sub-Saharan Africa, along with various other bla CTX-M, bla TEM, bla SHV, and bla OXA variants. These genes confer resistance to multiple beta-lactam antibiotics.
Prevalence of ESBL-producing Escherichia coli in sub-Saharan Africa: A meta-analysis using a One Health approach.
The study identifies bla CTX-M-15 as the most frequently reported ESBL gene in sub-Saharan Africa, along with various other bla CTX-M, bla TEM, bla SHV, and bla OXA variants. These genes confer resistance to multiple beta-lactam antibiotics.
Prevalence of ESBL-producing Escherichia coli in sub-Saharan Africa: A meta-analysis using a One Health approach.
The study identifies bla CTX-M-15 as the most frequently reported ESBL gene in sub-Saharan Africa, along with various other bla CTX-M, bla TEM, bla SHV, and bla OXA variants. These genes confer resistance to multiple beta-lactam antibiotics.
Prevalence of ESBL-producing Escherichia coli in sub-Saharan Africa: A meta-analysis using a One Health approach.
The study identifies bla CTX-M-15 as the most frequently reported ESBL gene in sub-Saharan Africa, along with various other bla CTX-M, bla TEM, bla SHV, and bla OXA variants. These genes confer resistance to multiple beta-lactam antibiotics.
Prevalence of ESBL-producing Escherichia coli in sub-Saharan Africa: A meta-analysis using a One Health approach.
The study identifies bla CTX-M-15 as the most frequently reported ESBL gene in sub-Saharan Africa, along with various other bla CTX-M, bla TEM, bla SHV, and bla OXA variants. These genes confer resistance to multiple beta-lactam antibiotics.
Prevalence of ESBL-producing Escherichia coli in sub-Saharan Africa: A meta-analysis using a One Health approach.
The study identifies bla CTX-M-15 as the most frequently reported ESBL gene in sub-Saharan Africa, along with various other bla CTX-M, bla TEM, bla SHV, and bla OXA variants. These genes confer resistance to multiple beta-lactam antibiotics.
Prevalence of ESBL-producing Escherichia coli in sub-Saharan Africa: A meta-analysis using a One Health approach.
The study identifies bla CTX-M-15 as the most frequently reported ESBL gene in sub-Saharan Africa, along with various other bla CTX-M, bla TEM, bla SHV, and bla OXA variants. These genes confer resistance to multiple beta-lactam antibiotics.
Genomic analysis of Salmonella enterica from cattle, beef and humans in the Greater Tamale Metropolis of Ghana.
Four raw beef isolates harbored at least one gene conferring resistance to beta-lactam (blaTEM-1), chloramphenicol (catA), fosfomycin (fosA7), quinolone (qnrD1), or tetracycline (tet(A)).
Bacteriological quality of fresh and processed black soldier fly Hermetia illucens larvae reared on chicken manure in Kitwe, Zambia.
The study identified bla CTX-M and bla TEM genes in E. coli isolates from fresh black soldier fly larvae, indicating the presence of extended-spectrum beta-lactamase (ESBL) resistance. The mecA gene was not detected in Staphylococcus isolates.
Dissemination of KPC-2-producing carbapenem-resistant Klebsiella pneumoniae ST792 in Southern China.
The study identifies multiple AMR genes, including blaKPC-2, qnrS1, blaCTX-M-3, blaTEM-1B, and blaSHV-1, in KPC-2-producing carbapenem-resistant Klebsiella pneumoniae ST792 isolates, highlighting their multidrug-resistant phenotype and plasmid-mediated transmission.
Retrospective analysis of antimicrobial resistance of Salmonella spp. isolated from livestock and its environment in Thailand.
The study identified several AMR genes in Salmonella isolates from livestock and their environment in Thailand, including aadA1, aadA2, aadB, aac(6')-Ia, blaTEM, tetA, tetB, catA, catB, cmlA, sulI, and dfrA1, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, tetracyclines, chloramphenicol, sulfamethoxazole, and trimethoprim.
Molecular epidemiology of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae bloodstream infections from Aberdeen, Scotland, and their comparison to isolates from England.
The study identified several AMR genes, including bla SHV, bla CTX-M, bla TEM, and mcr-9.1, in ESBL-producing Klebsiella pneumoniae isolates from Aberdeen, Scotland, and England. These genes conferred resistance to various antibiotics, including ceftazidime, cefotaxime, cefuroxime, and colistin.
Assessment of the environmental transmission dynamics of Escherichia coli-producing ESBL in wet market broiler chickens: A high-burden food safety concern.
The study identified bla CTX-M and bla TEM genes as the primary ESBL genes in ESBL-producing E. coli from broiler and free-range chickens in Surabaya, Indonesia. bla CTX-M was the most prevalent, followed by bla TEM.
Phenotypic and Genotypic Characterization of ESBL and AmpC beta-lactamase-Producing E. coli Isolates from Poultry in Northwestern Romania.
The study identified the presence of ESBL and AmpC beta-lactamase-producing E. coli isolates from poultry in northwestern Romania, highlighting the prevalence of resistance genes blaTEM, blaZ, and AmpC, which contribute to resistance against β-lactam antibiotics.
Molecular Identification and Antimicrobial Resistance Characteristics of Extended-Spectrum Beta-Lactamase Producing Klebsiella pneumoniae Isolated from Captive Wild and Migratory Birds.
The study identified extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae in captive wild and migratory birds in Bangladesh, highlighting the presence of resistance genes such as bla TEM-1&2, bla SHV-1, bla OXA-1,4&30, strA, tetA, and sul1, which contribute to multidrug resistance.
Genomic evolution and dissemination of non-conjugative virulence plasmid of ST65 carbapenem-resistant and hypervirulent Klebsiella pneumoniae strains in a Chinese hospital.
The study identifies the presence of multiple AMR genes, including blaKPC-2, aac(3)-IId, blaTEM-1, and blaCTX-M-15, in ST65 carbapenem-resistant and hypervirulent Klebsiella pneumoniae strains. It also characterizes virulence genes such as iucABCD-iutA, iroBCD-iroN, rmpA, and rmpA2. The research highlights the role of IncM2 plasmids in mobilizing non-conjugative virulence plasmids and the occurrence of IS 26-mediated plasmid fusion.
Detection and Characterization of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Raw Seafood From the Coastal Area of Bangladesh.
The study identified ESBL-producing E. coli in raw seafood from Bangladesh, with bla TEM, bla SHV, and bla CTX-M genes conferring resistance to beta-lactam antibiotics.
Characterizing antimicrobial resistance and plasmidome diversity in Escherichia coli from imported frozen broiler chicken in the United Arab Emirates.
The study identified several AMR genes in E. coli isolates from imported frozen broiler chicken in the UAE, including bla CTX-M-55, bla CTX-M-8, bla TEM-1B, aadA1, qnrS1, tetA, sul1, sul2, and sul3. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, and sulfonamides.
Prevalence and antimicrobial resistance of Salmonella and pathogenic E. coli in broiler farms, Wakiso district, Uganda.
The study identified the bla TEM gene as a significant contributor to antimicrobial resistance in Salmonella and pathogenic E. coli isolates from broiler farms in Wakiso district, Uganda.
Cooperative resistance varies among beta-lactamases in E. coli, with some enabling cross-protection and sustained extracellular activity.
The study identifies seven beta-lactamase genes (bla ampC, bla TEM-1, bla CTX-M-15, bla CMY-2, bla NDM-5, bla KPC-2, and bla OXA-181) in E. coli that contribute to cooperative resistance, with varying levels of efficacy in rescuing susceptible cells and facilitating cross-protection against β-lactam antibiotics.
Variants of beta-lactamase-encoding genes are disseminated by multiple genetically distinct lineages of bloodstream Escherichia coli.
The study identified multiple beta-lactamase genes, including bla TEM-1, bla CTX-M-15, and bla OXA-1, along with other AMR genes such as aadA5, aph(3")-Ib, aph(6)-Id, mphA, sul1, sul2, tetA, dfrA17, and aac(6')-Ib-cr5, which confer resistance to various antimicrobial classes in bloodstream E. coli isolates.
Genomic insights into multidrug - resistant Salmonella enterica isolates from pet dogs and cats.
The study identified multiple AMR genes in multidrug-resistant Salmonella enterica isolates from pet dogs and cats, including aac(6')-Iaa, aadA1, aadA2, blaTEM-1B, qacL, sul3, tet(A), qnrS1, fosA7, dfrA12, cmlA1, aph(3')-Ib, aph(6)-Id, blaCTX-M-55, blaTEM-215, and floR, which confer resistance to various antibiotics such as ampicillin, tetracycline, sulfamethoxazole, ciprofloxacin, and chloramphenicol.
Genomic insights into multidrug - resistant Salmonella enterica isolates from pet dogs and cats.
The study identified multiple AMR genes in multidrug-resistant Salmonella enterica isolates from pet dogs and cats, including aac(6')-Iaa, aadA1, aadA2, blaTEM-1B, qacL, sul3, tet(A), qnrS1, fosA7, dfrA12, cmlA1, aph(3')-Ib, aph(6)-Id, blaCTX-M-55, blaTEM-215, and floR, which confer resistance to various antibiotics such as ampicillin, tetracycline, sulfamethoxazole, ciprofloxacin, and chloramphenicol.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica.
The study identified several AMR genes in E. coli isolates from two sloth species in Costa Rica, including blaTEM-1B, aph(3')-Id, aph(6)-Id, tet(A), tet(B), sul2, qnrS1, floR, and dfrA8, which were associated with resistance to various antibiotics.
ESBL-producing Enterobacterales in food and clinical samples: antimicrobial resistance organisms and genes in Chiang Mai, Thailand.
The study identified bla CTX-M and bla TEM genes in ESBL-producing Enterobacterales from food and clinical samples in Chiang Mai, Thailand, highlighting their prevalence and distribution.
Antimicrobial resistance and beta-lactamase gene distribution among clinical isolates: a two-year cohort study.
The study identified several beta-lactamase genes, including blaCTX-M, blaSHV, blaTEM, blaOXA-48, blaKPC, blaVIM, and blaNDM, which are associated with resistance to various antibiotics in E. coli isolates.
Design, construction and efficiency analysis of bagasse-based charcoal packed horizontal lab-scale wetland for the removal of antibiotic-resistant bacteria.
The study identified blaTEM as a gene responsible for beta-lactam resistance in antibiotic-resistant bacteria isolated from domestic wastewater, demonstrating its presence in 50% of MDR isolates from influent samples.
Massive culture-based approach for the screening of AmpC, ESBL, and carbapenemase producers from rectal swabs.
The study presents a massive culture-based approach for the screening of AmpC, ESBL, and carbapenemase producers from rectal swabs, demonstrating improved specificity for detecting ESBL producers compared to conventional methods. It identifies various beta-lactamase genes, including bla CTX-M-1/2-like, bla CTX-M-8-like, bla CTX-M-9-like, bla SHV-like, bla TEM-like, bla GES-like, bla MOX, bla CIT, bla DHA, bla ACC, bla EBC, bla FOX, bla CMY-2, and bla NDM.
Molecular characterization of multidrug-resistant and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolated from Sonali chicken meat in Bangladesh.
The study identified several beta-lactam resistance genes, including blaTEM, blaCTX-M-2a, blaOXA-1, blaCMY, and blaNDM-1, in multidrug-resistant and ESBL-producing E. coli isolates from Sonali chicken meat in Bangladesh.
Prevalence and characterization of ESBL-producing diarrheagenic Escherichia coli from the poultry industry in Shanghai, China.
The study identified several beta-lactamase genes, including bla TEM-1B, bla CTX-M-55, bla OXA-10, and bla CTX-M-65, which confer resistance to various antibiotics in ESBL-producing diarrheagenic E. coli isolates from poultry farms in Shanghai, China.
Genetic characteristics and risk factors of extended-spectrum beta-lactamase-producing Escherichia coli in Chinese intensive care unit: a prospective molecular epidemiology study.
The study identified CTX-M-14, CTX-M-15, and CTX-M-55 as the most common ESBL genes in ESBL-EC isolates from the ICU, along with OXA-1 and TEM-20. ST10, ST131, and ST1193 were the predominant sequence types.
Antimicrobial resistance and virulence gene profiles of Escherichia coli isolated from poultry farms using One Health perspective in Abeokuta, Nigeria.
The study identified 30 different resistance determinants in 14 whole genome sequenced E. coli isolates from poultry farms in Abeokuta, Nigeria. These included genes such as blaTEM-1B, blaCARB-2, aph(3'')-Ib, aph(6)-Id, floR, sul1, sul2, tet(A), and tet(B), among others, which conferred resistance to various antimicrobial classes.
Higher-order epistasis drives evolutionary unpredictability toward novel antibiotic resistance.
The study characterizes the TEM-1 beta-lactamase and identifies multiple mutations that enhance resistance to various beta-lactam antibiotics, emphasizing the role of higher-order epistasis in the evolution of extended-spectrum beta-lactamase (ESBL) activity.
Overlooked Enterobacterales as hosts of antimicrobial resistance in aquatic environments.
The study identified several AMR genes in environmental Enterobacterales isolates, including blaTEM-1, blaCTX-M, tetA, tetB, tetC, tetL, tetM, sul1, sul2, qnrS, ermB, and mefA, which conferred resistance to various antibiotics such as ampicillin, ceftazidime, cefepime, tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and erythromycin.
Density-dependent feedback limits the spread of beta-lactamase mutants: experimental observations and population dynamic model.
The study characterizes the beta-lactamase mutants TEM-19 and TEM-52, highlighting their differential resistance to cefotaxime and the impact of population density and antibiotic concentration on their coexistence.
Density-dependent feedback limits the spread of beta-lactamase mutants: experimental observations and population dynamic model.
The study characterizes the beta-lactamase mutants TEM-19 and TEM-52, highlighting their differential resistance to cefotaxime and the impact of population density and antibiotic concentration on their coexistence.
Emerging Trends of Beta-Lactamases in Western Nepal: A Growing Public Health Concern.
The study identified the prevalence of ESBL, AmpC, and carbapenemase-producing clinical isolates of Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. ESBL production was the predominant mechanism of resistance to beta-lactam drugs, followed by AmpC and carbapenemase production.
Biofilm Formation and Antibiotic Resistance Genes of Escherichia coli From Poultry Farms and Clinical Samples.
The study identified several AMR genes in E. coli isolates from poultry and clinical samples, including blaTEM, gyrA, gyrB, qnrB, qnrB4, qnrS, blaCTX-M, sul1, sul2, tetA, and tetB. These genes conferred resistance to various antibiotics such as beta-lactams, fluoroquinolones, sulfonamides, and tetracyclines. High levels of resistance were observed against tylosin, neomycin, tetracycline, ampicillin, doxycycline, ciprofloxacin, and trimethoprim/sulfamethoxazole.
Multidrug-Resistant Extended-Spectrum Beta-Lactamase (ESBL) Producing Escherichia coli in Pet Birds of Bangladesh.
The study identified TEM and CTX-M beta-lactamase genes in multidrug-resistant ESBL-producing E. coli isolated from pet birds in Bangladesh, highlighting the presence of these resistance mechanisms in the avian population.
Genomic insights into bacteriophages: a new frontier in AMR detection and phage therapy.
The paper discusses the identification of various AMR genes in Acinetobacter baumannii and other pathogens, highlighting their role in resistance to multiple antibiotics and the potential of phage therapy as an alternative treatment.
The Microbiological Characteristics and Genomic Surveillance of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Clinical Samples.
The study identified multiple carbapenemase genes, including bla NDM-5, bla NDM-1, and bla OXA-232, as well as extended-spectrum beta-lactamases like bla CTX-M-15. Mutations in porin genes ompK36 and ompK37, and regulatory genes acrR and ramR, were associated with reduced susceptibility to carbapenems, cephalosporins, fluoroquinolones, and tigecycline.
Population Structure, Genomic Features, and Antibiotic Resistance of Avian Pathogenic Escherichia coli in Shandong Province and Adjacent Regions, China (2008-2023).
The study identified multiple antibiotic resistance genes and mutations in Avian Pathogenic Escherichia coli (APEC) isolates from Shandong Province and adjacent regions in China, highlighting the high prevalence of multidrug resistance and the presence of specific resistance mechanisms such as beta-lactamases, tetracycline resistance genes, and fluoroquinolone resistance mutations.
Isolation and Molecular Characterization of Antimicrobial-Resistant Bacteria from Vegetable Foods.
The study identified several antimicrobial resistance genes in Enterobacteriaceae isolated from vegetables, including TEM, CTX-M IV, SHV, OXA, CMY II, DHA, tetA, tetW, sul-I, and qnrD, which confer resistance to beta-lactams, tetracyclines, sulfonamides, and quinolones.
Genomic characterization of an ESBL-producing Klebsiella pneumoniae ST37 recovered from a hospitalized patient in Armenia.
The study identified several AMR genes in the ESBL-producing K. pneumoniae ST37 isolate ARM02, including blaTEM-1D, blaSHV-11, dfrA14, sul2, strA, strB, and blaCTX-M-15, which were directly linked to the observed resistance phenotypes.
Bacterial strain type and TEM-1 enzyme allele impact antibiotic susceptibility distribution in monoclonal populations: a single-cell droplet approach.
The study characterizes the impact of TEM-1 beta-lactamase alleles (R164S and G238S) on antibiotic susceptibility in E. coli strains, demonstrating that increased catalytic activity correlates with higher resistance to cefotaxime.
Bacterial strain type and TEM-1 enzyme allele impact antibiotic susceptibility distribution in monoclonal populations: a single-cell droplet approach.
The study characterizes the impact of TEM-1 beta-lactamase alleles (R164S and G238S) on antibiotic susceptibility in E. coli strains, demonstrating that increased catalytic activity correlates with higher resistance to cefotaxime.
Bacterial strain type and TEM-1 enzyme allele impact antibiotic susceptibility distribution in monoclonal populations: a single-cell droplet approach.
The study characterizes the impact of TEM-1 beta-lactamase alleles (R164S and G238S) on antibiotic susceptibility in E. coli strains, demonstrating that increased catalytic activity correlates with higher resistance to cefotaxime.
Metagenomic analysis after selective culture enrichment of hospital and community wastewater enhances antimicrobial resistance gene detection.
The study identifies various beta-lactamase genes such as bla CTX-M, bla KPC, bla NDM, and bla VIM, along with other resistance genes like erm(TR), lsa, efrA, efrB, and optrA, which were detected through selective culture enrichment of wastewater samples.
Extended spectrum β-lactamase-producing Enterobacterales in live and dead birds from rural poultry farms and urban live bird markets of Bangladesh.
The study identified blaTEM, blaSHV, and blaCTX-M genes as the primary contributors to extended-spectrum beta-lactamase (ESBL) resistance in Enterobacterales from poultry in Bangladesh. ESBL-producing E. coli was the most prevalent species, with high resistance rates to multiple antibiotic classes.
Uncovering hidden threats: prevalence, antibiotic resistance and virulence gene profiles of Escherichia coli strains isolated from Testudines and their aquatic habitats.
The study identified various antibiotic resistance genes in E. coli isolates from Testudines and their aquatic habitats, including mcr-1, mcr-2, mcr-4, bla TEM, bla SHV, qnrA, qnrD, eaeA, virF, stx1, and stx2. These genes confer resistance to colistin, cephalothin, ampicillin, ciprofloxacin, and nalidixic acid, highlighting the presence of multidrug-resistant E. coli in wild reptiles and their environments.
Analyzing Shigella in Wuhan: Serotypes, Antimicrobial Resistance, and Public Health Implications.
The study identified multiple AMR genes and mutations in Shigella flexneri isolates from Wuhan, including blaCTX-M, blaOXA, blaTEM, dfrA1, sul2, tetB, aadA1, and qnrS, along with specific mutations in gyrA, parC, and parE that confer resistance to various antibiotics.
Epidemiology of potential source, risk attribution of Clostridium perfringens from Egyptian broiler farms and genetic diversity of multidrug resistance strains.
The study identified multiple AMR genes in Clostridium perfringens isolates from Egyptian broiler farms, including aminoglycoside, beta-lactam, macrolide, quinolone, sulfonamide, tetracycline, and trimethoprim resistance genes. High prevalence of multidrug-resistant strains was observed.
Ecological connectivity of genomic markers of antimicrobial resistance in Escherichia coli in Hong Kong.
The study identifies various antimicrobial resistance genes in E. coli isolates from Hong Kong, including blaTEM-1, floR, tet(A), aph(3')-Ia, blaNDM, tet(X4), and mcr, which confer resistance to multiple antibiotics.
Investigation into the occurrence and molecular characteristics of Salmonella from food animals in Shandong, China.
The study identified several AMR genes in Salmonella isolates from food animals in Shandong, China, including blaTEM, blaCTX-M, qnrS, oqxA, oqxB, aph(3')-II, aac(6')-Ib-cr, rmtB, mcr-1, and mphA, which confer resistance to various antibiotics such as ampicillin, cefotaxime, ciprofloxacin, gentamicin, amikacin, colistin, and azithromycin.
Plasmid-driven clonal expansion of multidrug-resistant monophasic Salmonella Typhimurium in a Global Food Trade Hub.
The study identifies several AMR genes and mutations in multidrug-resistant Salmonella 1,4,[5],12:i:-, including aac(6')-Iaa, tet(B), blaTEM-1B, blaOXA-1, qnrS1, mcr-1.1, blaCTX-M-14, blaCTX-M-55, blaNDM-5, and sul2, which contribute to resistance against various antibiotics.
Whole-genome sequencing and bioinformatic tools powered by machine learning to identify antibiotic-resistant genes and virulence factors in Escherichia coli from sepsis.
The study identified several known and novel antibiotic-resistant genes in E. coli isolates from sepsis patients using whole-genome sequencing and machine learning. Key findings include the presence of blaCTX-M, blaSHV, blaTEM, aac(6')-Ib, aadA, qnrS1, ermB, mexAB-OprM, acrAB-TolC, and oqxAB genes, which confer resistance to various antibiotics.
Multidrug-resistant E. Coli in wastewater sources: a comparative study and identification of resistance hotspots.
The study identified bla TEM, bla CTX-M, and bla OXA-48 as the most prevalent beta-lactamase genes in multidrug-resistant E. coli isolates from wastewater sources.
Tracking Enterobacteria, microbiomes, and antibiotic resistance genes from waste to soil with repeated compost applications.
The study identifies several AMR genes including bla CTX-M, bla TEM-1B, bla SHV-12, qnr A, qnr B, aac(6')-Ib, sul 1, sul 2, intI 1, and intI 2 in Enterobacteria from composts and raw waste, highlighting their persistence and potential spread in tropical soils.
Low prevalence but high resistance of Extended Spectrum Beta-lactamase producing Klebsiella pneumoniae isolated from Hospitals in the Ashanti Region of Ghana.
The study identified blaCTX-M, blaSHV, and blaTEM genes in ESBL-producing Klebsiella pneumoniae isolates, contributing to high resistance to cephalosporins.
Salmonella serovars in a tertiary hospital in Turkey, 2015-2017: molecular epidemiology, antimicrobial resistance and molecular characteristics of resistance mechanisms.
The study identified TEM-type beta-lactamases in two ceftriaxone-resistant Salmonella isolates, highlighting the presence of extended-spectrum beta-lactamase (ESBL) production. Additionally, colistin resistance was observed in 29.6% of the isolates, although no mcr-1 or mcr-2 genes were detected.
Molecular and Drug Resistance Characteristics of Haemophilus influenzae Carried by Pediatric Patients with Adenoid Hypertrophy.
The study identified bla TEM-1 and bla ROB-1 beta-lactamase genes and mutations in the ftsI gene (encoding PBP3) as key contributors to beta-lactam resistance in H. influenzae strains isolated from pediatric patients with adenoid hypertrophy.
Molecular Surveillance of ESBL and Carbapenemase Genes in Gram-Negative Bacterial Pathogens Isolated from Various Clinical Samples Collected from Northern Region of United Arab Emirates.
The study identified the presence of ESBL and carbapenemase genes, including bla CTX-M, bla TEM, bla SHV, bla NDM, and bla IMP, in various Gram-negative bacterial pathogens isolated from clinical samples in the northern region of the UAE. These genes were found to confer resistance to multiple antibiotics, highlighting the need for molecular surveillance to monitor and control the spread of multidrug-resistant bacteria.
The bacterial etiology and antimicrobial susceptibility of lower respiratory tract infections in Vietnam.
The study identified several AMR genes, including bla CTX-M-1, bla CTX-M-9, bla TEM, bla SHV, bla OXA-23, bla OXA-48, bla NDM, bla KPC, and mecA, which were associated with resistance to various antibiotics in different bacterial pathogens.
One health approach unravels worrying antimicrobial resistance patterns: A cross-sectional study in Kisii, Kenya.
The study identified several AMR genes, including blaTEM, blaOXA-48, blaSHV, blaCTXM-15, blaCTXM-8, blaCTXM-1, blaCTXM-9, blaVIM, and blaNDM, which were associated with resistance to various antibiotics in Enterobacterales isolates from human, animal, and environmental samples in Kisii, Kenya.
The investigation of bacteria in the oral of Trichomonas gallinae infected pigeons and the antibiotic resistance analysis of Klebsiella pneumoniae clinical isolates from farm pigeons in Shandong Province of China.
The study identified multiple antibiotic resistance genes in Klebsiella pneumoniae isolates from farm pigeons in Shandong Province, including bla-SHV, bla-TEM, bla-CTX-M-9, qnrB, tetA, and aac(6')-Ib, highlighting the presence of multidrug-resistant strains.
Molecular and phenotypic characteristics of isolated Escherichia coli from the skin, gills, and intestine of rainbow trout in retail stores of Kerman, Iran.
The study identified several AMR genes in E. coli isolates from rainbow trout, including blaTEM, qnrA, tetB, sul1, and sul2, which confer resistance to beta-lactams, fluoroquinolones, tetracyclines, and sulfonamides.
Towards the integration of antibiotic resistance gene mobility into environmental surveillance and risk assessment.
The study highlights the importance of incorporating antibiotic resistance gene (ARG) mobility into environmental surveillance and risk assessment. It identifies specific ARGs such as bla OXA, bla KPC-2, bla TEM-1, bla GES-2, bla GES-5, sul 1, and sul 2 as highly mobile and potentially risky in various environmental settings.
An NGS-assisted diagnostic workflow for culture-independent detection of bloodstream pathogens and prediction of antimicrobial resistances in sepsis.
The study evaluated the diagnostic performance of PISTE™ technology, an NGS-based workflow for detecting bloodstream pathogens and predicting antimicrobial resistance. It showed high accuracy in identifying pathogens and predicting resistance genes, including beta-lactamases, carbapenemases, aminoglycoside modifying enzymes, tetracycline efflux pumps, and quinolone resistance proteins.
Research note: Emergence of bla(NDM-13) producing Escherichia coli from a broiler chicken and farm environment in Jiangsu Province, China.
The study identified blaNDM-13-producing E. coli strains in a chicken farm in Jiangsu Province, China, which exhibit multidrug resistance, including resistance to carbapenems, aminoglycosides, fluoroquinolones, tetracyclines, sulfonamides, and florfenicol. The study also characterizes the plasmids carrying blaNDM-13 and confirms their ability to transfer between bacteria.
Phenotypic, Targeted Genotypic, and Antimicrobial Susceptibility Profiling of Extended-Spectrum β-Lactamase Production and Exclusive bla(OXA)-48 Gene Detection in Escherichia coli and Klebsiella pneumoniae Isolates From a South Lebanese Hospital.
The study identified blaCTX-M, blaTEM, and blaSHV as the most prevalent ESBL genes in E. coli and K. pneumoniae isolates, while blaOXA-48 was detected in a small proportion of CRE isolates.
Clinical characteristics, specific resistance patterns, and molecular mechanisms of carbapenem-resistant Morganella morganii isolates.
The study identified blaTEM and blaCTX-M-1 as ESBL genes contributing to carbapenem resistance in M. morganii, along with specific PBP mutations in mrcA, pbpC, and mdrA that correlate with imipenem resistance.
Resistance Profiles and Virulence Factors of Enteric Escherichia coli in Chronic Kidney Disease Patients at Laquintinie Hospital in Douala, Cameroon.
The study identified bla TEM, bla CTX-M, bla SHV, and bla OXA as the most prevalent ESBL resistance genes in E. coli isolates from chronic kidney disease patients, contributing to high levels of antibiotic resistance.
Global phylogeography and genomic characterization of bla(NDM-1)-positive clinical Proteus mirabilis isolates from China.
The study identifies blaNDM-1 as a key determinant of carbapenem resistance in Proteus mirabilis isolates from China, along with other resistance genes such as blaCTX-M-14, blaCTX-M-65, and blaTEM-1. It also characterizes the genomic context of blaNDM-1, including its integration into SGI1 and plasmid-borne elements.
Phenotype-genotype discordance in antimicrobial resistance profiles of Gram-negative uropathogens recovered from catheter-associated urinary tract infections in Egypt.
The study identifies several new AMR variants in uropathogens from Egypt, including blaOXA-486, blaOXA-488, blaOXA-905, blaIMP-43, blaPDC-35, blaPDC-45, blaPDC-201 in Pseudomonas aeruginosa, and blaTEM-176, blaTEM-190 in Escherichia coli.
Phenotype-genotype discordance in antimicrobial resistance profiles of Gram-negative uropathogens recovered from catheter-associated urinary tract infections in Egypt.
The study identifies several new AMR variants in uropathogens from Egypt, including blaOXA-486, blaOXA-488, blaOXA-905, blaIMP-43, blaPDC-35, blaPDC-45, blaPDC-201 in Pseudomonas aeruginosa, and blaTEM-176, blaTEM-190 in Escherichia coli.
Characterization of Aeromonas hydrophila isolated from freshwater fish with control trial.
The study identified the presence of the bla TEM gene, which confers resistance to beta-lactam antibiotics, and the aadA1 gene, which confers resistance to streptomycin, in Aeromonas hydrophila isolates from freshwater fish in Egypt.
Extended-Spectrum beta-lactamase-Producing Klebsiella pneumoniae in Southwest China: Molecular Characteristics and Risk Factors of Bloodstream Infections.
The study identified bla TEM, bla SHV, and bla CTX-M genes, with bla CTX-M-15 being the predominant variant in ESBL-producing Klebsiella pneumoniae isolates from bloodstream infections in Southwest China.
Molecular Characteristics of Epidemiologically Successful Salmonella Enteritidis in Poland.
The study identified several AMR genes and mutations in Salmonella Enteritidis strains, including qnrB19, blaTEM-1, blaTEM-135, tet(A), sul2, and mutations in gyrA (S83Y, D87Y, S83F, S464Y).
Molecular Characteristics of Epidemiologically Successful Salmonella Enteritidis in Poland.
The study identified several AMR genes and mutations in Salmonella Enteritidis strains, including qnrB19, blaTEM-1, blaTEM-135, tet(A), sul2, and mutations in gyrA (S83Y, D87Y, S83F, S464Y).
Antibiotic resistance and novel Sequence Types of Klebsiella spp. in human, animal, and food sources: a One Health perspective from Northern Nigeria.
The study identified various AMR genes in Klebsiella spp. isolates from human, animal, and food sources, including strB, qnrS1, sul2, tetA, dfrA14, blaTEM-1, and blaSHV-11, which conferred resistance to multiple antibiotics.
Whole-Genome Sequencing Uncovers Chromosomal and Plasmid-Borne Multidrug Resistance and Virulence Genes in Poultry-Associated Escherichia coli from Nigeria.
The study identified multiple antimicrobial resistance genes in a multidrug-resistant E. coli strain from poultry in Nigeria, including blaCTX-M-15, blaOXA-1, blaTEM-1, aac(6')-Ib-cr, aadA5, aph(3'')-Ib, sul1, sul2, tet(A), mph(A), and dfrA17, highlighting the role of plasmids in the spread of resistance.
Antimicrobial Resistant Salmonella in Canal Water in Bangkok, Thailand: Survey Results Between 2016 and 2019.
The study identified the presence of extended-spectrum beta-lactamase (ESBL) genes, primarily blaCTX-M, in Salmonella isolates from Bangkok's canal water, along with class 1 integrons, highlighting the spread of antimicrobial resistance in urban environments.
Phenotypic and Molecular Study of Multidrug-Resistant Escherichia coli Isolates Expressing Diverse Resistance and Virulence Genes from Broilers in Tunisia.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from broilers in Tunisia, including bla CTX-M-G1, bla TEM, bla SHV, bla OXA-48, bla IMP, mcr-1, aadA-1, aadA-5, aac(6)-Ib-cr, qnrS, and qnrB.
Genetic Diversity, Extended-Spectrum Beta-Lactamase (ESBL) Screening, and Potential Public Health Implications of Gram-Negative Bacteria Recovered from Man-Made Lakes and Surrounding Vegetables.
The study identified the presence of ESBL-producing E. coli isolates carrying the bla CTX-M and bla TEM genes, which confer resistance to multiple beta-lactam antibiotics.
Antimicrobial Resistance and Genomic Characterization of an Escherichia coli Strain Harboring p0111 and an IncX1-Type Plasmid, Isolated from the Brain of an Ostrich.
The study identifies multiple antimicrobial resistance genes in an Escherichia coli strain isolated from an ostrich, including bla CTX-M-55, rmtB, sul1, APH(6)-Id, tet(A), AAC(3)-IIc, aadA2, bla TEM-1B, and floR, which confer resistance to various antibiotics such as cephalosporins, aminoglycosides, sulfonamides, tetracyclines, and chloramphenicol.
Prevalence, Antibiotic Resistance, and Biofilm Formation of Proteus mirabilis in Dairy Products: Implications for Veterinary and Public Health.
The study identified several antibiotic resistance genes in Proteus mirabilis isolates from dairy products, including blaCTX-M, blaSHV, blaTEM, aac(3)IIa, and Sul1, which confer resistance to various antibiotics such as cephalothin, gentamicin, and cotrimoxazole.
Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.
The study identifies 42 antimicrobial resistance (AMR) genes in the pan-drug resistant Klebsiella pneumoniae isolate KPNW, including beta-lactamases (bla CTX-M-15, bla NDM-1, bla OXA-1, bla TEM-63, bla TEM-104, bla SHV-28), tetracycline resistance genes (tet(A)), and efflux pump genes (oqxA, oqxB, marA, marR, ompK37, pbp3, crp, h-ns, kpnG, kpnH, parC, rsmA). Additionally, the isolate shows resistance to polymyxin B and colistin through modifications in lipid A (eptB, arnT, lptD, msbA, vanG) and other mechanisms.
Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.
The study identifies 42 antimicrobial resistance (AMR) genes in the pan-drug resistant Klebsiella pneumoniae isolate KPNW, including beta-lactamases (bla CTX-M-15, bla NDM-1, bla OXA-1, bla TEM-63, bla TEM-104, bla SHV-28), tetracycline resistance genes (tet(A)), and efflux pump genes (oqxA, oqxB, marA, marR, ompK37, pbp3, crp, h-ns, kpnG, kpnH, parC, rsmA). Additionally, the isolate shows resistance to polymyxin B and colistin through modifications in lipid A (eptB, arnT, lptD, msbA, vanG) and other mechanisms.
Antimicrobial-Resistant Bacteria in Environmental Samples From a Rural District Focused on Large-Scale Agricultural Production.
The study identified blaTEM-like and blaCTX-M-1/2-like genes in various environmental samples, indicating the presence of extended-spectrum beta-lactamase-producing bacteria in agricultural and livestock environments.
Antibiotic resistance in white stork cloaca and environmental samples
The study identified various antibiotic resistance genes in bacterial isolates from white stork cloaca and environmental samples, highlighting the presence of resistance mechanisms against beta-lactams, aminoglycosides, quinolones, and polymyxins.
In-depth characterization of virulence traits, pathogenicity, antibiogram, and antibiotic resistance genes of MDR Vibrio parahaemolyticus retrieved from shrimp.
The study identified multiple antibiotic resistance genes in MDR Vibrio parahaemolyticus strains isolated from shrimp, including bla TEM, bla OXA, tet A, aad A, erm B, and sul 1, which confer resistance to various antibiotics.
Detection of the blaTEM gene on multidrug-resistant Escherichia coli producing extended spectrum beta-lactamase from ducks in live poultry markets in Surabaya, Indonesia.
The study identified the blaTEM gene in multidrug-resistant Escherichia coli isolates from ducks in live poultry markets in Surabaya, Indonesia, highlighting the presence of extended-spectrum beta-lactamase-producing bacteria.
Genetic diversity, virulence genes, antimicrobial resistance, and biofilm formation of Klebsiella pneumoniae isolated from bovine mastitis milk in South Korea.
The study identified several AMR genes in K. pneumoniae isolates from bovine mastitis milk in South Korea, including blaSHV, strA, strB, sulI, sulII, tetA, tetB, tetC, floR, dfrXII, blaTEM, blaCTX-M, and blaOXA, which confer resistance to various antibiotics such as ampicillin, gentamicin, trimethoprim/sulfamethoxazole, tetracycline, chloramphenicol, and others.
Molecular characterization of drug-resistance genes and dynamics of multidrug-resistant Salmonella spp. in waterfowl: a pre- and post-antibiotic ban surveillance in Guangdong, China from 2013 to 2023.
The study identified several AMR genes in Salmonella isolates from waterfowl in Guangdong, China, including bla CTX-M, bla TEM, bla OXA, aad A1, aad A2, aac C2, aac (3)-IV, aph (3’)-I, qnr A, qnr S, clm A, flo R, tet (A), and Sul II. These genes were associated with resistance to various antibiotics such as β-lactams, aminoglycosides, quinolones, chloramphenicol, tetracyclines, and sulfonamides.
Antimicrobial resistance profiles and genomic insights of phenotypically extended spectrum beta-lactamase-positive Klebsiella pneumoniae from cattle farms.
The study identifies multiple AMR genes, including bla TEM, bla SHV, bla AmpC, qnrS, and tetA, in phenotypically ESBL-positive K. pneumoniae isolates from cattle farms in Punjab, India. These genes confer resistance to various antibiotics, highlighting the potential for AMR spread in livestock environments.
ESBL-producing Klebsiella pneumoniae gut colonisation and subsequent health-care associated bacteraemia in preterm newborns: a descriptive cohort with nested case-control study.
The study identifies several AMR genes, including bla CTX-M-1, bla SHV, bla TEM, bla OXA-48, bla NDM, and bla VIM, in ESBL-producing K. pneumoniae isolates from preterm neonates. These genes confer resistance to various beta-lactam antibiotics and carbapenems.
Environmental Dissemination of Multidrug-Resistant Gram-Negative Pathogens in Djibouti's Wastewaters.
The study identifies multidrug-resistant gram-negative bacteria in Djibouti's wastewaters, highlighting the presence of ESBL gene bla CTX-M-15 and carbapenemase gene bla OXA-48, indicating significant antibiotic resistance mechanisms.
Environmental Dissemination of Multidrug-Resistant Gram-Negative Pathogens in Djibouti's Wastewaters.
The study identifies multidrug-resistant gram-negative bacteria in Djibouti's wastewaters, highlighting the presence of ESBL gene bla CTX-M-15 and carbapenemase gene bla OXA-48, indicating significant antibiotic resistance mechanisms.
Environmental Dissemination of Multidrug-Resistant Gram-Negative Pathogens in Djibouti's Wastewaters.
The study identifies multidrug-resistant gram-negative bacteria in Djibouti's wastewaters, highlighting the presence of ESBL gene bla CTX-M-15 and carbapenemase gene bla OXA-48, indicating significant antibiotic resistance mechanisms.
Global genomic and antimicrobial resistance profiling of Neisseria gonorrhoeae: Insights from whole genome sequencing and minimum inhibitory concentration analysis.
The study identifies key resistance mechanisms in Neisseria gonorrhoeae, including the widespread presence of efflux pump genes (norM, farB, mtrC, mtrA) and specific resistance genes such as bla TEM, tet(C), and erm(C). It highlights the increasing prevalence of antimicrobial resistance and the need for global surveillance and targeted interventions.
Prevalence of multi-drug resistant and extended-spectrum β-lactamase producing Escherichia coli and Klebsiella pneumoniae among meat products sold at Sohag Governorate, Egypt.
The study identified bla CTX-M, bla TEM, dfrA, stx1, and stx2 genes in E. coli isolates from meat products in Sohag Governorate, Egypt, highlighting the presence of multidrug-resistant and extended-spectrum beta-lactamase-producing strains.
Resistance, virulence and genetic diversity of Salmonella Typhimurium in South Africa (1999-2021).
The study identified several AMR genes in Salmonella Typhimurium isolates from South Africa, including beta-lactamases (bla PSE, bla CMY-2, bla TEM, bla SHV), sulfonamide resistance genes (sul1, sul2, sul3), fluoroquinolone resistance genes (qnrA, qnrB, qnrS), tetracycline resistance genes (tetA, tetB), and trimethoprim resistance genes (dfrXI, dfrXII).
No evidence of multidrug-resistant Enterobacterales transmission between healthy companion animals and pet owners in the greater Atlanta area: a pilot study.
The study identified several AMR genes and mutations in E. coli isolates from both humans and pets, including blaCMY-2, blaCTX-M-15, blaTEM-1B, and mutations in gyrA and parC. These findings highlight the presence of multidrug-resistant Enterobacterales in healthy individuals and their companion animals.
Persistent multispecies dissemination of armA-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital.
The study identifies the persistent dissemination of armA-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital, highlighting the role of these plasmids in the spread of aminoglycoside resistance.
Molecular identification of antibiotic-resistant and virulent Escherichia coli and Staphylococcus aureus isolated from dogs in Southern Benin.
The study identified several antibiotic resistance genes in Escherichia coli and Staphylococcus aureus isolated from dogs in Southern Benin, including blaTEM, tetA, strA-strB, tetK, tetM, and blaZ, which confer resistance to penicillin, tetracycline, and streptomycin.
Antibiogram and Detection of Resistant Genes in Escherichia coli Isolated From Meat and Meat Products of Kathmandu, Nepal.
The study identified ESBL genes bla CTX and bla TEM-52, and colistin resistance gene mcr-1 in E. coli isolates from meat and meat products in Kathmandu, Nepal.
Environmental factors driving antimicrobial resistance in Indian flying foxes (Pteropus medius): one health implications.
The study identified blaTEM and blaCTX-M genes in E. coli isolates from Indian flying foxes, indicating environmental AMR exposure. blaTEM was prevalent in both seasons, while blaCTX-M was detected only in winter samples.
Differences and fingerprints of ESBL-producing E. coli from chicken faeces.
The study identified several beta-lactamase genes, including bla CTX-M, bla CTX-M-1, bla CTX-M-15, bla TEM, and bla OXA-10, in ESBL-producing E. coli isolates from chicken faeces. These genes were detected through PCR and phenotypic testing, highlighting their prevalence and role in conferring resistance to beta-lactam antibiotics.
Antibiotic resistance and β-lactam resistant genes among bacterial isolates from clinical, river water and poultry samples from Kathmandu, Nepal.
The study identified blaTEM, mcr-1, blaNDM-1, and mecA genes in various bacterial isolates from clinical, poultry, and water samples in Kathmandu, Nepal, highlighting the presence of multidrug-resistant bacteria and resistance genes across different sources.
Rapid detection of gram-negative antimicrobial resistance determinants directly from positive blood culture broths using a multiplex PCR system.
The study evaluated the BIOFIRE FILMARRAY Antimicrobial Resistance (AMR) Panel for rapid detection of AMR genes in gram-negative bacteria from positive blood culture broths. It identified several AMR genes, including beta-lactamases (TEM-1, SHV-1, CTX-M, KPC, NDM, OXA-1, OXA-23), AmpC beta-lactamases (CMY/MOX, DHA), aminoglycoside modifying enzymes (AAC(6′)-Ib-cr), and fluoroquinolone resistance mutations (ParC-S80I, GyrA-S83F/I/L).
Plasmid-mediated quinolone resistance among extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolated from hospitalized patients, hospital environment and wastewaters in Cameroon.
The study identified aac-(6')-Ib-cr, qnrS, blaCTX-M, blaTEM, and blaSHV as the primary AMR genes in ESBL-producing E. coli and K. pneumoniae in Cameroon. These genes were associated with resistance to fluoroquinolones and beta-lactam antibiotics.
Extended spectrum beta-lactamase and integron genes among Shigella flexneri and Shigella sonnei isolated from children with diarrhea in shiraz, Southwest Iran.
The study identified the presence of ESBL genes bla CTX−M, bla TEM, and bla SHV, along with integron classes 1 and 2, in Shigella flexneri and Shigella sonnei isolates, highlighting a high prevalence of multidrug-resistant strains.
Community gut colonization by tet(X4)-positive multidrug-resistant Escherichia coli in healthy individuals from urban residents in Shenzhen, China.
The study identifies tet(X4)-positive multidrug-resistant E. coli in healthy individuals from urban areas in Shenzhen, China, highlighting the presence of tigecycline resistance and other resistance genes in the community gut microbiota.
Molecular characterization of antimicrobial resistance genes and plasmid profiles in enterobacterales isolated from urinary tract infections in rural outpatient women in Otavalo, Ecuador.
The study identified four prevalent antibiotic resistance genes, with bla TEM being the most common (87.01% of isolates), followed by bla CTX−M−1 (44.16%), bla SHV (18.83%), and bla CTX−M−9 (13.64%).
A beta-lactamase inhibitory protein mutant displays high potency and a broad inhibition profile due to an altered binding mode with beta-lactamases.
The BLIP E73W mutant exhibits high potency and a broad inhibition profile against class A beta-lactamases, achieved through a distinct binding mode that allows it to inhibit multiple beta-lactamase variants effectively.
Prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae isolated from animals in Bangladesh: A systematic review and meta-analysis.
The study identified bla CTX-M, bla TEM, and bla SHV as the most prevalent ESBL genes in Enterobacteriaceae isolates from animals in Bangladesh, highlighting their association with multidrug resistance.
Exploring the Relationship Between Biofilm Formation and Antibiotic Resistance Genes in Clinically Isolated Klebsiella pneumoniae.
The study identifies the presence of biofilm-associated gene mrkA and antibiotic resistance genes blaSHV and blaTEM in clinically isolated Klebsiella pneumoniae. It reveals a significant association between the presence of mrkA and elevated expression of blaSHV, suggesting a potential link between biofilm formation and antibiotic resistance.
Azithromycin resistance in nontyphoidal Salmonella in an urban informal settlement in Nairobi, Kenya.
The study identified several AMR genes in nontyphoidal Salmonella isolates, including aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, ant(3")-Ia, sul1, sul2, dfrA1, dfrA8, tetA, mph(A), bla CTX-M-3, bla TEM-135, bla TEM-1B, and bla TEM-1C. These genes conferred resistance to various antibiotics such as aminoglycosides, sulfonamides, tetracycline, macrolides, and beta-lactams.
Azithromycin resistance in nontyphoidal Salmonella in an urban informal settlement in Nairobi, Kenya.
The study identified several AMR genes in nontyphoidal Salmonella isolates, including aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, ant(3")-Ia, sul1, sul2, dfrA1, dfrA8, tetA, mph(A), bla CTX-M-3, bla TEM-135, bla TEM-1B, and bla TEM-1C. These genes conferred resistance to various antibiotics such as aminoglycosides, sulfonamides, tetracycline, macrolides, and beta-lactams.
Azithromycin resistance in nontyphoidal Salmonella in an urban informal settlement in Nairobi, Kenya.
The study identified several AMR genes in nontyphoidal Salmonella isolates, including aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, ant(3")-Ia, sul1, sul2, dfrA1, dfrA8, tetA, mph(A), bla CTX-M-3, bla TEM-135, bla TEM-1B, and bla TEM-1C. These genes conferred resistance to various antibiotics such as aminoglycosides, sulfonamides, tetracycline, macrolides, and beta-lactams.
Climate-driven co-evolution of antimicrobial resistance and virulence in Escherichia coli on dairy farms: unraveling adaptive genetic signatures with novel SSCP-PCR.
The study identifies mutations in blaTEM, gyrB, and fimH genes in E. coli isolates from dairy farms, correlating with antimicrobial resistance and virulence. Mutations in 16S rRNA and lacI were also observed, indicating potential co-evolution under climate-driven pressures.
Co-Occurrence and Molecular Characterization of ESBL-Producing and Colistin-Resistant Escherichia coli Isolates from Retail Raw Meat.
The study identified blaCTX-M-1 as the predominant ESBL gene in E. coli isolates from retail meat, alongside blaTEM and mcr-1, with mcr-2 detected in one isolate. Colistin resistance was primarily associated with mcr-1, and co-occurrence of resistance genes was observed in poultry and lamb meat.
Antimicrobial multidrug resistance of Escherichia coli from broiler farms in Zhanjiang, China.
The study identified multiple AMR genes in E. coli isolates from broiler farms in Zhanjiang, China, including bla TEM, bla AIM, pexA, aadA1, ant(3")-I, sul2, and sul3, which were associated with multidrug resistance to various antibiotics.
Global genomic survey of Salmonella Kentucky: discovery of a chromosomeborne bla(NDM-5) and the emergence of ST314, an MDR clone mediated by the IncR plasmid.
The study discovered a chromosome-borne bla(NDM-5) gene in Salmonella Kentucky and identified the IncR plasmid as a key mediator of antimicrobial resistance in the MDR clone ST314.
Global genomic survey of Salmonella Kentucky: discovery of a chromosomeborne bla(NDM-5) and the emergence of ST314, an MDR clone mediated by the IncR plasmid.
The study discovered a chromosome-borne bla(NDM-5) gene in Salmonella Kentucky and identified the IncR plasmid as a key mediator of antimicrobial resistance in the MDR clone ST314.
Molecular characterization of extended spectrum beta lactamase producing Escherichia coli in two different wastewater treatment plants in Hatay Province, Türkiye.
The study identified several extended spectrum beta lactamase (ESBL) genes, including bla CTX-M, bla CTX-M-15, bla CTX-M-55, bla CTX-M-1, bla CTX-M-3, bla TEM, and bla CMY-2, in ESBL-producing Escherichia coli isolates from wastewater treatment plants in Hatay Province, Türkiye. Additionally, quinolone resistance genes such as aac(6)-Ib, qnrA, and qnrB, and disinfectant resistance genes like qacEΔ1, ydgE, ydgF, mdfA, emrE, sugE(c), and sugE(p) were also detected.
Pathogenic potential of amoxicillin-clavulanic acid resistant Klebsiella pneumoniae isolated from aquatic environment: a study of multidrug resistance and virulence.
The study identified several AMR genes in AMC-resistant K. pneumoniae isolates from aquatic environments, including bla TEM, bla SHV, bla CTX-M, bla NDM, bla OXA-48, bla CMY, qnr S, qnr B, tet A, tet B, sul 1, dfr A12, intl 1, intl 2, mrk D, ecp A, and iuc C. These genes were associated with resistance to multiple antibiotics, highlighting the complex resistance profiles of these isolates.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
One health approach on zoonotic multidrug-resistant Klebsiella pneumoniae isolated from Egyptian cattle, horses, and humans.
The study identified blaTEM and TetA(A) genes in multidrug-resistant Klebsiella pneumoniae isolates from Egyptian cattle, horses, and humans, indicating resistance to amoxicillin-clavulanic, ceftriaxone, cefotaxime, and tetracycline.
Prevalence and Genetic Characterization of Antimicrobial-resistant Escherichia coli from Wild Boar Meat in Japan.
The study identified antimicrobial-resistant Escherichia coli in wild boar meat in Japan, with resistance genes including blaTEM, strA, strB, aacC2, aphA1, tetA, and tetB.
Novel antimicrobial strategy: native postbiotics synergize with antibiotics to overcome resistance in Klebsiella pneumoniae.
Native postbiotics synergize with antibiotics to overcome resistance in Klebsiella pneumoniae by reducing the expression of resistance genes such as bla NDM, bla CTX, bla TEM, and bla SHV.
Antibiotic Use in Livestock: A Driver of Resistance in Africa and the Path to Safer Alternatives.
The paper reviews the impact of antibiotic use in livestock on the rise of antibiotic resistance in Africa, highlighting the prevalence of resistance genes against multiple antibiotic classes and the transmission of resistant bacteria to humans through various routes.
Food Safety Threats: Molecular Surveillance, Antibiogram and Virulence Profiling of Biofilm Forming Enterococcus faecalis in Bangladeshi Restaurants.
The study identified blaTEM as a prevalent gene encoding beta-lactamase in Enterococcus faecalis isolates from Bangladeshi restaurants, indicating resistance to penicillin.
Diarrheagenic and ESBL Potential of Escherichia coli From Publicly Shared Common Touch Surfaces.
The study identified ESBL-producing E. coli isolates carrying bla TEM-1 and bla CTX-M genes, which conferred resistance to multiple beta-lactam antibiotics. Most isolates were multidrug-resistant.
Escherichia coli O157:H7 prevalence in Upper Egypt: impacts on food safety and human Health, with a protection trial using natural antibacterial Piper cubeba.
The study identified blaTEM, tetA, and Aada1 as the most common resistance genes in multidrug-resistant E. coli O157:H7 isolates in Upper Egypt. These genes confer resistance to beta-lactams, tetracyclines, and aminoglycosides, respectively.
Genomic epidemiology of strains currently and formerly classified as Enterobacter spp. recovered from equine necropsy samples.
The study identified several AMR genes in Enterobacter spp. strains, including beta-lactamases (blaDHA-1, blaOXA-1, blaSHV-12, blaTEM-1B), aminoglycoside resistance genes (aac(6')-ib_cr), quinolone resistance genes (qnrB2, qnrB4), and fosfomycin resistance genes (fosA, fosA2). These genes contribute to resistance against multiple antibiotic classes.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
Analysis of avian pathogenic Escherichia Coli (APEC) and its antimicrobial resistance risk characteristics and critical control points in laying hens.
The study identified several AMR genes in APEC isolates, including tet(A), floR, sul2, aph(3')-Ib, aph(6)-Id, bla TEM-1B, qnrS1, bla CTX-M-55, dfrA14, and mph(A), which contribute to resistance against tetracyclines, florfenicol, sulfonamides, aminoglycosides, beta-lactams, fluoroquinolones, and macrolides.
Analysis of avian pathogenic Escherichia Coli (APEC) and its antimicrobial resistance risk characteristics and critical control points in laying hens.
The study identified several AMR genes in APEC isolates, including tet(A), floR, sul2, aph(3')-Ib, aph(6)-Id, bla TEM-1B, qnrS1, bla CTX-M-55, dfrA14, and mph(A), which contribute to resistance against tetracyclines, florfenicol, sulfonamides, aminoglycosides, beta-lactams, fluoroquinolones, and macrolides.
Analysis of avian pathogenic Escherichia Coli (APEC) and its antimicrobial resistance risk characteristics and critical control points in laying hens.
The study identified several AMR genes in APEC isolates, including tet(A), floR, sul2, aph(3')-Ib, aph(6)-Id, bla TEM-1B, qnrS1, bla CTX-M-55, dfrA14, and mph(A), which contribute to resistance against tetracyclines, florfenicol, sulfonamides, aminoglycosides, beta-lactams, fluoroquinolones, and macrolides.
Analysis of avian pathogenic Escherichia Coli (APEC) and its antimicrobial resistance risk characteristics and critical control points in laying hens.
The study identified several AMR genes in APEC isolates, including tet(A), floR, sul2, aph(3')-Ib, aph(6)-Id, bla TEM-1B, qnrS1, bla CTX-M-55, dfrA14, and mph(A), which contribute to resistance against tetracyclines, florfenicol, sulfonamides, aminoglycosides, beta-lactams, fluoroquinolones, and macrolides.
Analysis of avian pathogenic Escherichia Coli (APEC) and its antimicrobial resistance risk characteristics and critical control points in laying hens.
The study identified several AMR genes in APEC isolates, including tet(A), floR, sul2, aph(3')-Ib, aph(6)-Id, bla TEM-1B, qnrS1, bla CTX-M-55, dfrA14, and mph(A), which contribute to resistance against tetracyclines, florfenicol, sulfonamides, aminoglycosides, beta-lactams, fluoroquinolones, and macrolides.
Antibiotic susceptibility pattern and resistance genes in Salmonella strains isolated from cattle.
The study identified tetracycline resistance genes tetA and tetC, and the beta-lactamase gene blaTEM-1 in Salmonella isolates from cattle, highlighting the prevalence of multidrug resistance.
Genomic characterization of Klebsiella pneumoniae clinical isolates from cancer patients: resistance profiles, virulence factors, and sequence typing.
The study identified several AMR genes in K. pneumoniae isolates from cancer patients, including genes conferring resistance to trimethoprim-sulfamethoxazole, tobramycin, levofloxacin, and carbapenems. Key resistance genes included sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA27, aadA16, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aph(4)-Ia, ACC(3)-IId, ACC(3)-IIV, AAC(6')-Ib-cr, QnrS1, QnrB17, QnrB20, QnrB4, CTX-M, SHV, TEM, DHA-1, LAP-2, bla_kpc-1, bla_ndm-5, and bla_oxa-10.
Frequency of Pseudomonas's Antibiotic Resistance and Virulence Genes in Poultry Meat.
The study identified several antibiotic resistance genes, including bla TEM, bla SHV, bla DHA, and others, in Pseudomonas aeruginosa isolates from poultry meat. Additionally, various virulence genes such as exoT, exoY, exoS, and exoU were detected.
Impact of synonymous mutations in the bla(TEM-3) gene on gene expression and Escherichia coli fitness.
Synonymous mutations in the blaTEM-3 gene increase ceftazidime resistance in Escherichia coli, likely due to epigenetic factors affecting gene stability.
Molecular characterization of Salmonella isolates from poultry in Egypt: Detection of virulence, ESBLs genes and antimicrobial resistance profiling.
The study identified the presence of ESBL genes (blaTEM, blaCTX-M, and blaSHV) in Salmonella isolates from poultry in Egypt, which were associated with high resistance to beta-lactam antibiotics. All isolates were resistant to ceftazidime, cefepime, and erythromycin, with high resistance rates observed against amoxicillin, amoxicillin-clavulanic acid, ciprofloxacin, and doxycycline.
Molecular characterization of ESBL- and carbapenemase-producing Enterobacteriaceae isolated from cats in Lebanon.
The study identified multiple AMR genes, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and bla NDM-5, in ESBL- and carbapenemase-producing Enterobacteriaceae isolated from cats in Lebanon, highlighting the role of cats as reservoirs of antimicrobial resistance.
Virulence and Antibiotic Resistance Profiles of Proteus mirabilis Strains Isolated From Broiler Chickens: Implications for Poultry and Public Health.
The study identified blaTEM and blaDHA genes in P. mirabilis isolates from broiler chickens, which confer resistance to various beta-lactam antibiotics. High resistance rates were observed against chloramphenicol and trimethoprim/sulfamethoxazole, while all isolates were susceptible to meropenem and cefepime.
Multidrug-resistant Klebsiella pneumoniae and Klebsiella oxytoca isolated from backyard broiler chickens and their contacts with antimicrobial resistance genes of Klebsiella pneumoniae.
The study identified multiple antimicrobial resistance genes in Klebsiella pneumoniae and Klebsiella oxytoca isolates from backyard broiler chickens and human contacts, including ermB, blaTEM, blaCTX-M1, sul1, tetA, gyrA, blaOXA-48, and mcr-1, indicating widespread multidrug resistance.
Isolation and characterization of Salmonella enterica serovars from poultry in Egypt: a comprehensive genetic analysis of ESBLs, MCR, integron and other resistance genes.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from poultry in Egypt, including bla TEM, bla SHV, bla CTX-M, bla OXA-10, bla CMY-2, mcr-1, and intI 1. These genes were associated with resistance to various antibiotics, highlighting the presence of multidrug-resistant strains.
Susceptibility of a peri-urban water supply and sanitation system to selected emerging micropollutants.
The study identified the presence of antibiotic resistance genes (ARGs) in most samples, including tetA, blaTEM, and intl1, which were detected in raw and treated sewage, as well as in river water after sewage discharge. These genes were found to confer resistance to tetracycline, beta-lactam, and multidrug, respectively.
Transfer of blaTEM gene between Salmonella and Escherichia coli under processing conditions of animal products: influence of a copper(II) complex.
The study demonstrates that the blaTEM gene can be horizontally transferred between Salmonella Heidelberg and E. coli J53 AzR, particularly in liquid media supplemented with whey or chicken juice. The copper(II) complex Lu54 effectively reduces this conjugation frequency.
Nanopore targeted sequencing in lower respiratory infections: a retrospective study on diagnostic applications, clinical characterization, and antimicrobial guidance.
The study identified 16 distinct AMR genes in 15 patients using NTS, highlighting the effectiveness of NTS in detecting resistance genes in ESKAPE pathogens.
Genomic characterisation of multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from various sources in Algeria, North Africa.
The study identified multiple AMR genes and chromosomal mutations in multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from Algeria, including bla TEM-1B, bla CTX-M-15, aac(3)-Id, aadA7, sul1, tet(A), mph(A), qnrB19, cmlA1, and floR, along with mutations in gyrA and parC genes that confer resistance to ciprofloxacin.
Genomic characterisation of multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from various sources in Algeria, North Africa.
The study identified multiple AMR genes and chromosomal mutations in multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from Algeria, including bla TEM-1B, bla CTX-M-15, aac(3)-Id, aadA7, sul1, tet(A), mph(A), qnrB19, cmlA1, and floR, along with mutations in gyrA and parC genes that confer resistance to ciprofloxacin.
Genomic characterisation of multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from various sources in Algeria, North Africa.
The study identified multiple AMR genes and chromosomal mutations in multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from Algeria, including bla TEM-1B, bla CTX-M-15, aac(3)-Id, aadA7, sul1, tet(A), mph(A), qnrB19, cmlA1, and floR, along with mutations in gyrA and parC genes that confer resistance to ciprofloxacin.
Ultrasound-Assisted Extraction: Unlocking the Antibacterial Potential of Coptis chinensis Franch. Against ESBL-Producing Enterobacterales.
The study identifies multiple beta-lactamase resistance genes in ESBL-PE strains, including blaCTX-M-14, blaCTX-M-1, blaCTX-M-3, blaCTX-M-15, blaCTX-M-65, blaSHV, blaTEM, blaEC, blaACC, blaCMY, blaACT, blaDHA, and efflux pump genes such as acrF, emrD, mdtM, silA, kdeA, oqxA, oqxB, arsB, oqxA10, oqxB5, oqxB19, arsA, and hugA, which contribute to multidrug resistance in these isolates.
Characterisation of Plasmid-Associated Antimicrobial Resistance Genes in Coastal Marine Enterobacterales from the Central Adriatic Sea: De Novo Assembly and Bioinformatic Profiling.
The study identified nine clinically relevant antimicrobial resistance genes (ARGs) in plasmid-like assemblies from marine Enterobacterales, including blaKPC, blaTEM, aacA4, folP, and tetA, highlighting the potential for horizontal gene transfer in coastal environments.
Integrated Analysis of Salmonella Infantis in Chicken Meat: Epidemiological Surveillance, Antibiotic Resistance, and Potential Bioactive Control Agents.
The study identified multiple antibiotic resistance genes in Salmonella Infantis isolates from chicken meat, including blaTEM-1, aadA1, aphA1-IAB, and sul1, indicating multidrug resistance. Carvacrol showed the strongest antimicrobial activity against these isolates.
Global emergence of Acinetobacter baumannii International Clone 12 predominantly found in the Middle East.
The study identifies multiple acquired antimicrobial resistance genes in Acinetobacter baumannii International Clone 12, including bla OXA-23, bla GES-11, bla GES-12, bla GES-22, bla GES-35, bla CARB-16, bla CARB-49, aphA6a, aadB, strA, strB, cmlA1, aadA2b, sul1, drfA7, dfrA1, qacE, tet(B), tet(X3), msr(E), mph(E), bla TEM-1B, and aacC3. These genes contribute to resistance against various antibiotics, highlighting the complexity of resistance mechanisms in this clone.
Antibiotic susceptibility patterns of clinical isolates of salmonella species producing extended spectrum beta lactamases as predictor of multidrug resistance in a tertiary hospital, Southeastern Nigeria.
The study identified blaTEM, tetA, and sul1 as the most prevalent resistance genes in Salmonella isolates, which are associated with multidrug resistance and extended-spectrum beta-lactamase production.
Genomic and In Vivo Characterization of Antimicrobial Resistance and Virulence in UPEC Escherichia coli Isolated from Brazilian Cases of UTI.
The study identified multiple antimicrobial resistance genes in UPEC strains, including aac(3)-IId, AAC(6')-Ib-cr, APH(3')-Ib, APH(6')-Ib, sul2, dfrA17, tet(B), TEM-1, OXA-1, and SHV-12, which confer resistance to aminoglycosides, sulfonamides, tetracycline, and beta-lactams.
Whole genome sequencing of a hypermucoviscous, multidrug-resistant Klebsiella pneumoniae subsp. pneumoniae K219 isolated from human sputum.
The study identified four key antibiotic resistance genes in the genome of K. pneumoniae subsp. pneumoniae K219: fosA, blaNDM-7, blaSHV-80, and blaTEM-1B, which confer resistance to various antibiotics.
Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock.
The study identified multiple AMR genes in Citrobacter freundii isolates from Egyptian livestock, including bla TEM, bla CTX-M, bla OXA-10, bla CMY-2, qnrA, aadA1, sul2, dfrA1, ermB, tet(M), int1, and mcr-1, which confer resistance to various antibiotics.
Research of antimicrobial resistance and its associated genes distribution in Escherichia coli from diarrheic calves in the Ulagai region of China.
The study identified several antimicrobial resistance genes in E. coli isolates from diarrheic calves in the Ulagai region of China, including sul2, TEM-1, tetR, strB, QacH, floR, and CTXM-55, which were associated with resistance to various antibiotics.
Effect of surgical antimicrobial prophylaxis duration for colic surgery on complications and resistome.
The study found that extending surgical antimicrobial prophylaxis beyond 24 hours did not increase postoperative complications but led to a higher abundance of beta-lactam resistance genes, including TEM, BlaZ, SHV, CfxA, and PBP2, as well as aminoglycoside-modifying enzymes like AAC(6'), ANT(3"), ANT(6), APH(2"), APH(3'), APH(3"), and APH(6) in the fecal resistome of horses.
Alarming colistin and carbapenem resistance in Klebsiella pneumoniae: molecular insights from Tehran hospitals, Iran.
The study identified high prevalence of carbapenem and colistin resistance in Klebsiella pneumoniae isolates from Tehran hospitals, with bla TEM, bla SHV, bla CTX-M, bla NDM, and bla OXA-48 being the major resistance genes. Colistin resistance was observed in 16.7% of isolates, but no mcr genes were detected.
PanARGMiner (Pan-Genomic Antimicrobial Resistance Gene Miner): An advanced feature selection framework for extracting key resistance genes from pan-genomic datasets.
PanARGMiner effectively identifies key resistance genes from pan-genomic datasets, including both known and novel AMR genes, across multiple bacterial species.
Antimicrobial resistance, virulence defects, and evolutionary dynamics of multidrug-resistant Klebsiella pneumoniae from human and animal hosts in Central China.
The study identifies multiple AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae isolates from human and animal hosts in Central China, highlighting the role of plasmid-borne resistance genes and genetic variations affecting virulence.
Precise species identification and whole-genome sequencing analysis of Enterobacter cloacae complex causing bloodstream infections in China.
The study identified various AMR genes in Enterobacter cloacae complex (ECC) isolates, including bla ACT, bla NDM, and mcr-10, which confer resistance to beta-lactams, carbapenems, and polymyxins, respectively. It also found that E. roggenkampii was the most common species among carbapenem-resistant isolates and showed high resistance to both carbapenems and colistin.
Genomic epidemiology of antimicrobial resistance in Proteus mirabilis: core genome and plasmid-mediated drivers.
The study identified 197 AMR gene subtypes in Proteus mirabilis, including beta-lactamases (bla TEM-1, bla CTX-M-15, bla NDM-1), aminoglycoside-modifying enzymes (aac(6')-Ib-cr, aph(3'')-Ib), and other resistance determinants. Plasmids, particularly IncC plasmids, were found to be major carriers of these genes, contributing to the spread of multidrug resistance.
A Monitoring Method to Evaluate the Accumulation of Antimicrobial-Resistance Genes in Gram-Negative Bacteria Distributed in Environmental Water.
The study identified multiple antimicrobial resistance genes (ARGs) in Gram-negative bacteria isolated from environmental water samples, including bla NDM-5, bla CTX-M-27, bla DHA-1, and others, indicating the presence of carbapenem-resistant and extended-spectrum beta-lactamase-producing bacteria in the Vietnamese VAC ecosystem.
Roles of micro/nanoplastics in the spread of antimicrobial resistance through conjugative gene transfer.
The study shows that micro/nanoplastics (M/NPs) enhance the conjugative transfer of antibiotic resistance genes (ARGs) between bacteria, particularly in systems involving Escherichia coli and Enterococcus faecalis. The 20-nm and 1-μm PS M/NPs significantly facilitated ARG transfer, with the latter showing a stronger effect on E. coli recipients. The mechanism involves increased reactive oxygen species (ROS) production, altered cell membrane permeability, and changes in gene expression related to conjugation.
Comparative genomics reveals avian Acinetobacter baumannii as antimicrobial resistance reservoirs and bovine strains with elevated pathogenicity.
Avian Acinetobacter baumannii strains were found to carry a significantly higher number of antimicrobial resistance genes compared to bovine and porcine strains, highlighting their potential role in the dissemination of antimicrobial resistance through animal origin foods.
Prevalence and genetic basis of extended-spectrum beta-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
Detection and Preliminary Genomic Characterization of Poultry-Derived Salmonella enterica from Southern Kazakhstan.
The study identified multidrug-resistant Salmonella enterica isolates from poultry farms in southern Kazakhstan, with universal fluoroquinolone resistance and plasmid-borne AMR genes such as blaTEM-116, tet(A), sul1, ant(3")-Ia, and dfrA14.
In Vitro Evaluation of Fosfomycin Combinations Against Metallo-β-Lactamase-Producing Klebsiella pneumoniae and Pseudomonas aeruginosa Clinical Isolates.
The study evaluated the in vitro synergistic activity of fosfomycin (FOS) in combination with other antimicrobials against MBL-producing K. pneumoniae and P. aeruginosa. It found that FOS combinations showed significant synergy, particularly with CAZ-AVI and COL, suggesting their potential utility in treating infections caused by MBL-producing bacteria.
Prevalence of ESBL-Producing Escherichia coli on Neck Skin in Slaughtered Broilers Raised on Conventional, Antibiotic-Free, and Organic Farms.
The study identified various ESBL and AmpC genes, including bla CTX-M-1, bla CTX-M-9, bla TEM, bla SHV, bla OXA, bla CIT, bla MOX, bla DHA, bla ACC, bla EBC, and bla FOX, in ESBL-producing E. coli isolates from broiler neck skin. These genes were associated with resistance to beta-lactam antibiotics such as cefotaxime, ceftazidime, and cefoxitin.
Prevalence, antimicrobial resistance, and extended-spectrum β-lactamase gene profiles of Escherichia coli isolated from poultry eggshells in Can Tho City, Vietnam.
The study identified bla CTX-M, bla TEM, and bla NDM genes in ESBL-producing E. coli isolates from poultry eggshells in Can Tho City, Vietnam, highlighting the prevalence of multidrug-resistant strains and the potential for resistance gene dissemination through the food chain.
Genomic epidemiology of Salmonella Typhimurium and its monophasic variants in Southern China: A spatiotemporal and source attribution analysis.
The study identified blaTEM-1, tet(A), and sul2 as the most prevalent antimicrobial resistance genes in Salmonella Typhimurium isolates from Jiangxi Province, China. Additionally, point mutations in the quinolone resistance-determining region of the gyrA gene were found to be responsible for ciprofloxacin resistance.
Correlation of OXA-1 and TEM-1 genes with antibiotic resistance to piperacillin/tazobactam in ESBL-producing Enterobacterales: insights from a multi-center analysis.
The study found that the OXA-1 gene is significantly associated with reduced susceptibility to piperacillin/tazobactam in ESBL-producing Enterobacterales, while TEM-1 shows no significant association.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
The study identified mcr-1.1-harboring multidrug-resistant E. coli isolates from chicken in the UAE, highlighting the presence of various AMR genes and mutations contributing to resistance against multiple antibiotics, including colistin, beta-lactams, quinolones, and aminoglycosides.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
The study identified mcr-1.1-harboring multidrug-resistant E. coli isolates from chicken in the UAE, highlighting the presence of various AMR genes and mutations contributing to resistance against multiple antibiotics, including colistin, beta-lactams, quinolones, and aminoglycosides.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
The study identified mcr-1.1-harboring multidrug-resistant E. coli isolates from chicken in the UAE, highlighting the presence of various AMR genes and mutations contributing to resistance against multiple antibiotics, including colistin, beta-lactams, quinolones, and aminoglycosides.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
The study identified mcr-1.1-harboring multidrug-resistant E. coli isolates from chicken in the UAE, highlighting the presence of various AMR genes and mutations contributing to resistance against multiple antibiotics, including colistin, beta-lactams, quinolones, and aminoglycosides.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
The study identified mcr-1.1-harboring multidrug-resistant E. coli isolates from chicken in the UAE, highlighting the presence of various AMR genes and mutations contributing to resistance against multiple antibiotics, including colistin, beta-lactams, quinolones, and aminoglycosides.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
The study identified mcr-1.1-harboring multidrug-resistant E. coli isolates from chicken in the UAE, highlighting the presence of various AMR genes and mutations contributing to resistance against multiple antibiotics, including colistin, beta-lactams, quinolones, and aminoglycosides.
Novel insights into antimicrobial-resistant, virulent and biofilm-forming Salmonella: Molecular and phenotypic evidence from duck at the human-animal-environment interface.
The study identifies multiple ESBL genes (bla TEM, bla SHV, bla CTX-M, bla AmpC) and biofilm-related genes (csgA, rpoS, rcsA, sdiA) in Salmonella isolates from ducks, highlighting their role in antimicrobial resistance and virulence.
Novel insights into antimicrobial-resistant, virulent and biofilm-forming Salmonella: Molecular and phenotypic evidence from duck at the human-animal-environment interface.
The study identifies multiple ESBL genes (bla TEM, bla SHV, bla CTX-M, bla AmpC) and biofilm-related genes (csgA, rpoS, rcsA, sdiA) in Salmonella isolates from ducks, highlighting their role in antimicrobial resistance and virulence.
Novel insights into antimicrobial-resistant, virulent and biofilm-forming Salmonella: Molecular and phenotypic evidence from duck at the human-animal-environment interface.
The study identifies multiple ESBL genes (bla TEM, bla SHV, bla CTX-M, bla AmpC) and biofilm-related genes (csgA, rpoS, rcsA, sdiA) in Salmonella isolates from ducks, highlighting their role in antimicrobial resistance and virulence.
Novel insights into antimicrobial-resistant, virulent and biofilm-forming Salmonella: Molecular and phenotypic evidence from duck at the human-animal-environment interface.
The study identifies multiple ESBL genes (bla TEM, bla SHV, bla CTX-M, bla AmpC) and biofilm-related genes (csgA, rpoS, rcsA, sdiA) in Salmonella isolates from ducks, highlighting their role in antimicrobial resistance and virulence.
Penicillinase synthesis controlled by infectious R factors in Enterobacteriaceae.
Penicillinase synthesis controlled by infectious R factors in Enterobacteriaceae.
Outbreaks of hospital infection in southwest England caused by gentamicin-resistant Serratia marcescens.
The study identifies the presence of the beta-lactamase gene blaTEM-2 in gentamicin-resistant Serratia marcescens strains, which contributes to resistance against multiple antibiotics.
Molecular characterization of nine different types of mutants among 107 inhibitor-resistant TEM beta-lactamases from clinical isolates of Escherichia coli.
Molecular characterization of nine different types of mutants among 107 inhibitor-resistant TEM beta-lactamases from clinical isolates of Escherichia coli.
Molecular characterization of nine different types of mutants among 107 inhibitor-resistant TEM beta-lactamases from clinical isolates of Escherichia coli.
Molecular characterization of nine different types of mutants among 107 inhibitor-resistant TEM beta-lactamases from clinical isolates of Escherichia coli.
Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors.
Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors.
Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors.
Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors.
Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors.
Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors.
Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors.
Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors.
Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors.
Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors.
Novel, plasmid-encoded, TEM-derived extended-spectrum beta-lactamase in Klebsiella pneumoniae conferring higher resistance to aztreonam than to extended-spectrum cephalosporins.
Novel, plasmid-encoded, TEM-derived extended-spectrum beta-lactamase in Klebsiella pneumoniae conferring higher resistance to aztreonam than to extended-spectrum cephalosporins.
Novel, plasmid-encoded, TEM-derived extended-spectrum beta-lactamase in Klebsiella pneumoniae conferring higher resistance to aztreonam than to extended-spectrum cephalosporins.
Characterization of a new TEM-type beta-lactamase resistant to clavulanate, sulbactam, and tazobactam in a clinical isolate of Escherichia coli.
Characterization of a new TEM-type beta-lactamase resistant to clavulanate, sulbactam, and tazobactam in a clinical isolate of Escherichia coli.
Characterization of a new TEM-type beta-lactamase resistant to clavulanate, sulbactam, and tazobactam in a clinical isolate of Escherichia coli.
Incidence and mechanisms of resistance to the combination of amoxicillin and clavulanic acid in Escherichia coli.
The study identified several beta-lactamase genes, including blaTEM-1, blaTEM-2, and blaOXA-1, which contribute to resistance against amoxicillin-clavulanic acid in Escherichia coli. Additionally, specific mutations in blaTEM-1 were found to confer inhibitor resistance.
Incidence and mechanisms of resistance to the combination of amoxicillin and clavulanic acid in Escherichia coli.
The study identified several beta-lactamase genes, including blaTEM-1, blaTEM-2, and blaOXA-1, which contribute to resistance against amoxicillin-clavulanic acid in Escherichia coli. Additionally, specific mutations in blaTEM-1 were found to confer inhibitor resistance.
Incidence and mechanisms of resistance to the combination of amoxicillin and clavulanic acid in Escherichia coli.
Incidence and mechanisms of resistance to the combination of amoxicillin and clavulanic acid in Escherichia coli.
Incidence and mechanisms of resistance to the combination of amoxicillin and clavulanic acid in Escherichia coli.
Molecular characterisation by PCR-restriction fragment length polymorphism of TEM beta-lactamases.
Molecular characterisation by PCR-restriction fragment length polymorphism of TEM beta-lactamases.
Molecular characterisation by PCR-restriction fragment length polymorphism of TEM beta-lactamases.
TEM-28 from an Escherichia coli clinical isolate is a member of the His-164 family of TEM-1 extended-spectrum beta-lactamases.
TEM-28 from an Escherichia coli clinical isolate is a member of the His-164 family of TEM-1 extended-spectrum beta-lactamases.
TEM-28 from an Escherichia coli clinical isolate is a member of the His-164 family of TEM-1 extended-spectrum beta-lactamases.
TEM-28 from an Escherichia coli clinical isolate is a member of the His-164 family of TEM-1 extended-spectrum beta-lactamases.
Molecular diversity and evolution of blaTEM genes encoding beta-lactamases resistant to clavulanic acid in clinical E. coli.
Properties of IRT-14 (TEM-45), a newly characterized mutant of TEM-type beta-lactamases.
IRT-14 (TEM-45) is a mutant TEM-type beta-lactamase that confers resistance to broad-spectrum penicillins with reduced sensitivity to beta-lactamase inhibitors. Structural modifications and promoter region mutations contribute to this resistance.
Properties of IRT-14 (TEM-45), a newly characterized mutant of TEM-type beta-lactamases.
Properties of IRT-14 (TEM-45), a newly characterized mutant of TEM-type beta-lactamases.
Properties of IRT-14 (TEM-45), a newly characterized mutant of TEM-type beta-lactamases.
A natural polymorphism in beta-lactamase is a global suppressor.
Characterization of a new TEM-derived beta-lactamase produced in a Serratia marcescens strain.
A new TEM-derived beta-lactamase (blaTEM-10) was identified in a Serratia marcescens strain, showing high catalytic efficiency against ceftazidime and aztreonam, and mediating resistance to certain penicillins and the ampicillin-clavulanic acid combination.
Characterization of a new TEM-derived beta-lactamase produced in a Serratia marcescens strain.
Characterization of a new TEM-derived beta-lactamase produced in a Serratia marcescens strain.
Characterization of a new TEM-derived beta-lactamase produced in a Serratia marcescens strain.
Characterization of a new TEM-derived beta-lactamase produced in a Serratia marcescens strain.
A novel extended-spectrum TEM-type beta-lactamase (TEM-52) associated with decreased susceptibility to moxalactam in Klebsiella pneumoniae.
A novel extended-spectrum TEM-type beta-lactamase (TEM-52) associated with decreased susceptibility to moxalactam in Klebsiella pneumoniae.
A novel extended-spectrum TEM-type beta-lactamase (TEM-52) associated with decreased susceptibility to moxalactam in Klebsiella pneumoniae.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
The study identifies three novel TEM-type extended-spectrum beta-lactamases (TEM-47, TEM-48, and TEM-49) in ceftazidime-resistant Enterobacteriaceae isolates from Polish hospitals.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
The study identifies three novel TEM-type extended-spectrum beta-lactamases (TEM-47, TEM-48, and TEM-49) in ceftazidime-resistant Enterobacteriaceae isolates from Polish hospitals.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
The study identifies three novel TEM-type extended-spectrum beta-lactamases (TEM-47, TEM-48, and TEM-49) in ceftazidime-resistant Enterobacteriaceae isolates from Polish hospitals.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases.
Nosocomial outbreak of Klebsiella pneumoniae producing SHV-5 extended-spectrum beta-lactamase, originating from a contaminated ultrasonography coupling gel.
The study identifies SHV-5 and TEM-1 beta-lactamases as the primary resistance mechanisms in a nosocomial outbreak of ceftazidime-resistant Klebsiella pneumoniae, highlighting the role of contaminated ultrasonography coupling gel as a transmission source.
beta-Lactamases Responsible for Resistance to Expanded-Spectrum Cephalosporins in Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis Isolates Recovered in South Africa.
The study identifies TEM-26, SHV-2, SHV-5, and an AmpC beta-lactamase as the primary extended-spectrum beta-lactamases responsible for resistance to expanded-spectrum cephalosporins in K. pneumoniae, E. coli, and P. mirabilis isolates from South Africa.
Ceftazidime and aztreonam resistance in Providencia stuartii: characterization of a natural TEM-derived extended-spectrum beta-lactamase, TEM-60.
Ceftazidime and aztreonam resistance in Providencia stuartii: characterization of a natural TEM-derived extended-spectrum beta-lactamase, TEM-60.
Ceftazidime and aztreonam resistance in Providencia stuartii: characterization of a natural TEM-derived extended-spectrum beta-lactamase, TEM-60.
Ceftazidime and aztreonam resistance in Providencia stuartii: characterization of a natural TEM-derived extended-spectrum beta-lactamase, TEM-60.
Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 beta-lactamases from St. Louis, Missouri.
The study identifies TEM-10 and TEM-43 beta-lactamases as the causes of ceftazidime resistance in Klebsiella pneumoniae and Escherichia coli isolates from St. Louis, Missouri. TEM-43 shows broad-spectrum hydrolytic activity against penicillins and cephalosporins, including ceftazidime and aztreonam.
Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 beta-lactamases from St. Louis, Missouri.
The study identifies TEM-10 and TEM-43 beta-lactamases as the causes of ceftazidime resistance in Klebsiella pneumoniae and Escherichia coli isolates from St. Louis, Missouri. TEM-43 shows broad-spectrum hydrolytic activity against penicillins and cephalosporins, including ceftazidime and aztreonam.
Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 beta-lactamases from St. Louis, Missouri.
Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 beta-lactamases from St. Louis, Missouri.
Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 beta-lactamases from St. Louis, Missouri.
Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 beta-lactamases from St. Louis, Missouri.
Display of functional beta-lactamase inhibitory protein on the surface of M13 bacteriophage.
The study describes the display of the beta-lactamase inhibitory protein (BLIP) on the surface of M13 bacteriophage, demonstrating its ability to bind and inhibit TEM-1 beta-lactamase, which is responsible for resistance to penicillins and cephalosporins.
Outbreak of ceftazidime-resistant Klebsiella pneumoniae in a pediatric hospital in Warsaw, Poland: clonal spread of the TEM-47 extended-spectrum beta-lactamase (ESBL)-producing strain and transfer of a plasmid carrying the SHV-5-like ESBL-encoding gene.
The study identifies the TEM-47 and SHV-5 extended-spectrum beta-lactamases as the primary mechanisms of ceftazidime resistance in Klebsiella pneumoniae isolates from a pediatric hospital in Warsaw, Poland. These genes were found to be carried on plasmids and contributed to the clonal spread of resistant strains.
Updated sequence information for TEM beta-lactamase genes.
Updated sequence information for TEM beta-lactamase genes.
Updated sequence information for TEM beta-lactamase genes.
Updated sequence information for TEM beta-lactamase genes.
Updated sequence information for TEM beta-lactamase genes.
Updated sequence information for TEM beta-lactamase genes.
Updated sequence information for TEM beta-lactamase genes.
Updated sequence information for TEM beta-lactamase genes.
Updated sequence information for TEM beta-lactamase genes.
Updated sequence information for TEM beta-lactamase genes.
Updated sequence information for TEM beta-lactamase genes.
Updated sequence information for TEM beta-lactamase genes.
Updated sequence information for TEM beta-lactamase genes.
Updated sequence information for TEM beta-lactamase genes.
Molecular characterization of a ceftazidime-resistant Morganella morganii isolate producing a TEM-10 beta-lactamase.
The study identifies a TEM-10 beta-lactamase in a ceftazidime-resistant Morganella morganii isolate, which confers resistance to ceftazidime, aztreonam, and cefotaxime.
Molecular characterization of a ceftazidime-resistant Morganella morganii isolate producing a TEM-10 beta-lactamase.
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