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Explore antimicrobial resistance genes from the literature
extended-spectrum class A beta-lactamase VEB-10
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaVEB-10 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Proteus mirabilis | - | - | KM983336.1 | AJH76942.1 |
| blaVEB-11 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Pseudomonas aeruginosa | - | - | KP681692.1 | AKO63208.1 |
| blaVEB-12 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Pseudomonas aeruginosa | - | - | KP681693.1 | AKO63209.1 |
| blaVEB-17 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Escherichia coli | - | - | KU686219.1 | AMJ32272.1 |
| blaVEB-19 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Escherichia coli | - | - | KY997187.1 | ASC62380.1 |
| blaVEB-21 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Acinetobacter baumannii | - | - | MG717454.1 | AXH79874.1 |
| blaVEB-22 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Pseudomonas aeruginosa | - | - | MN201581.1 | QDQ43383.1 |
| blaVEB-23 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Enterobacter cloacae | - | - | MN715316.1 | QGN18751.1 |
| blaVEB-24 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Providencia rettgeri | - | - | MN715317.1 | QGN18752.1 |
| blaVEB-26 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Serratia marcescens | - | - | MT614293.1 | QKV50749.1 |
| blaVEB-27 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Providencia stuartii | - | - | MT872419.1 | QNG62078.1 |
| blaVEB-28 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Aeromonas veronii | - | - | MW598511.1 | QRV13259.1 |
| blaVEB-29 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Proteus mirabilis | - | - | MZ359765.1 | QWO25673.1 |
| blaVEB-30 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Proteus mirabilis | - | - | MZ394841.1 | QWT89343.1 |
| blaVEB-31 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Klebsiella pneumoniae | - | - | OP171927.1 | UUU46289.1 |
| blaVEB-32 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Aeromonas veronii | - | - | LC794539.1 | BEV74467.1 |
| blaVEB-33 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Aeromonas veronii | - | - | LC794540.1 | BEV74468.1 |
| blaVEB-34 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Acinetobacter variabilis | - | - | PP328955.1 | WVW91708.1 |
| blaVEB-35 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Providencia rettgeri | - | - | PQ394564.1 | XHO32907.1 |
| blaVEB-36 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Escherichia coli | - | - | PQ394565.1 | XHO32908.1 |
| blaVEB-37 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Proteus mirabilis | - | - | PQ394566.1 | XHO32909.1 |
| blaVEB-38 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Proteus mirabilis | - | - | PQ394567.1 | XHO32910.1 |
| blaVEB-39 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Pseudomonas aeruginosa | - | - | PQ394568.1 | XHO32911.1 |
| blaVEB-40 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Pseudomonas aeruginosa | - | - | PV075093.1 | XOU30560.1 |
| blaVEB-42 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Pseudomonas aeruginosa | - | - | PX132083.1 | XZC91450.1 |
| blaVEB-5 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN +7 | Escherichia coli +3 | Europe|Asia|North America|Western and South-Eastern Asia, Bangladesh|Brazil|Greece|Italy|Kenya|South Africa|Thailand|Uganda|Vietnam | 2022, 2023, 2024 | EF420108.1 | ABN80430.1 |
| blaVEB-7 | Card DatabaseReference Gene CatalogResFinder Database | 4 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Acinetobacter baumannii | - | - | FJ825622.1 | ACO56763.1 |
| blaVEB-8 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN +1 | Escherichia coli +1 | Switzerland | 2022 | JX679208.1 | AGH33739.1 |
| blaVEB-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 41 | ceftazidime, cefotaxime +28 | Acinetobacter baumannii AYE +14 | France, Bangkok, Thailand, Vietnam, Thailand, Singapore, Arabian Peninsula|Saudi Arabia|United Arab Emirates|Kuwait|Oman|Qatar|Bahrain, Nepal, Egypt, Iran, India, South West of Iran, Guadeloupe, Tehran|Qazvin|Iran, Spain, Australia, South-West Nigeria, Northern California|northern California|California, China, Japan, Asia/South Pacific|Europe|Latin America|Middle East/Africa|North America, Europe | 1999, 2001, 2002, 2003, 2006, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | CU459141.1 | CAM88398.1 |
| blaVEB-13 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Pseudomonas aeruginosa | - | 2016 | NG_050321.1 | WP_063865153.1 |
| blaVEB-14 | Card DatabaseReference Gene CatalogReslit | 4 | CEPHALOSPORIN, ceftazidime +1 | Pseudomonas aeruginosa +2 | - | 2016, 2020 | NG_050322.1 | WP_063865154.1 |
| blaVEB-15 | Card DatabaseReference Gene CatalogReslit | 4 | CEPHALOSPORIN, cephalosporins | Escherichia coli +1 | Brazil | 2016, 2022 | NG_050323.1 | WP_063865155.1 |
| blaVEB-20 | Card DatabaseReference Gene Catalog | 3 | CEPHALOSPORIN | Pseudomonas aeruginosa | - | 2020 | NG_063894.1 | WP_128268286.1 |
| blaVEB-25 | Card DatabaseReference Gene CatalogReslit | 7 | ceftazidime, ceftazidime avibactam +2 | Klebsiella pneumoniae subsp. pneumoniae +3 | Greece, Switzerland|Greece, Spain|China|Taiwan | 2020, 2023, 2025 | NG_067227.1 | WP_160164840.1 |
| blaVEB-16 | Card DatabaseReference Gene CatalogResFinder Database | 3 | AZTREONAM, TICARCILLIN +12 | Pseudomonas aeruginosa | - | 2001 | AF324834.1 | AAK14294.1 |
| blaVEB-9 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | TANIBORBACTAM, AZTREONAM +23 | Pseudomonas aeruginosa +5 | Warsaw, Poland|Poland|Canada, Croatia|India, Saudi Arabia, United States|Canada|Europe, USA|China|India|Thailand|Brazil|Hungary|South Africa|Egypt|Tunisia|Europe|Asia, Bulgaria | 2001, 2017, 2020, 2023, 2024 | AF324833.1 | AAK14293.1 |
| blaVEB-2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN +3 | Pseudomonas aeruginosa | Iraq | 2002, 2023 | AY027870.1 | AAK29174.1 |
| blaVEB-1a | Reslit | 4 | cefoxitin, cefotaxime +6 | Pseudomonas aeruginosa +6 | India, Americas|Argentina, Paris, France, Qatar | 2004, 2006, 2011, 2019 | AY444814|AY444815 | - |
| blaVEB-3 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN +8 | Enterobacter cloacae +6 | China, Taiwan | 2005, 2006, 2010, 2018, 2020, 2025 | AY536519.1 | AAS48620.1 |
| blaVEB-6 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 9 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN +6 | Proteus mirabilis +2 | Australia, France, Philippines|Texas, India, Egypt | 2008, 2009, 2017, 2020, 2024 | EU259884.2 | ACA34904.1 |
| blaVEB-4 | Card DatabaseReference Gene CatalogResFinder Database | 4 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Proteus mirabilis | - | 2008 | EF136375.1 | ABM54868.1 |
| blaVEB | Reslit | 15 | ceftazidime, cefotaxime +9 | Escherichia coli +12 | Thailand, Germany, Egypt, Turkey, Iran, Asia|Pacific, China, India, Europe|Poland, mid-Atlantic United States, Southern Thailand, Europe, Kuwait, Peru | 2008, 2013, 2018, 2021, 2022, 2023, 2024, 2025 | LC383793|LC420047 | - |
| VEB | Reslit | 3 | ceftazidime, ceftriaxone +3 | Escherichia coli +1 | North of Iran, Vietnam, Tanzania|Thailand|human|swine | 2015, 2016, 2019 | - | - |
| blaVEB-18 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Vibrio parahaemolyticus | - | 2017 | KX539265.1 | ANU78819.1 |
| bla(VEB) | Reslit | 1 | aztreonam, ceftazidime +1 | Pseudomonas aeruginosa | Iran | 2022 | - | - |
| bla(VEB-25) | Reslit | 1 | ceftazidime avibactam | Klebsiella pneumoniae | Greece | 2023 | NC-012731 | - |
Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum beta-lactamase encoded by an Escherichia coli integron gene.
VEB-1 is a novel class A extended-spectrum beta-lactamase encoded by an Escherichia coli integron gene, which confers high-level resistance to various beta-lactam antibiotics including ceftazidime, cefotaxime, aztreonam, cefuroxime, piperacillin, ticarcillin, and amoxicillin.
Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum beta-lactamase encoded by an Escherichia coli integron gene.
Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum beta-lactamase encoded by an Escherichia coli integron gene.
Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum beta-lactamase encoded by an Escherichia coli integron gene.
Molecular epidemiology of the integron-located VEB-1 extended-spectrum beta-lactamase in nosocomial enterobacterial isolates in Bangkok, Thailand.
The study identifies the VEB-1 extended-spectrum beta-lactamase as a significant cause of ceftazidime resistance in nosocomial enterobacterial isolates in Bangkok, Thailand. The gene is located on class 1 integrons and is associated with other resistance genes such as blaOXA-10 and arr-2.
VEB-1-like extended-spectrum beta-lactamases in Pseudomonas aeruginosa, Kuwait.
VEB-1-like extended-spectrum beta-lactamases in Pseudomonas aeruginosa, Kuwait.
VEB-1-like extended-spectrum beta-lactamases in Pseudomonas aeruginosa, Kuwait.
VEB-1-like extended-spectrum beta-lactamases in Pseudomonas aeruginosa, Kuwait.
VEB-1-like extended-spectrum beta-lactamases in Pseudomonas aeruginosa, Kuwait.
VEB-1-like extended-spectrum beta-lactamases in Pseudomonas aeruginosa, Kuwait.
Nosocomial spread of the integron-located veb-1-like cassette encoding an extended-pectrum beta-lactamase in Pseudomonas aeruginosa in Thailand.
Nosocomial spread of the integron-located veb-1-like cassette encoding an extended-pectrum beta-lactamase in Pseudomonas aeruginosa in Thailand.
Nosocomial spread of the integron-located veb-1-like cassette encoding an extended-pectrum beta-lactamase in Pseudomonas aeruginosa in Thailand.
Nosocomial spread of the integron-located veb-1-like cassette encoding an extended-pectrum beta-lactamase in Pseudomonas aeruginosa in Thailand.
Distribution of extended-spectrum beta-lactamases in clinical isolates of Enterobacteriaceae in Vietnam.
The study identified several extended-spectrum beta-lactamases, including bla TEM-1, bla SHV-2, bla VEB-1, bla CTX-M-14, and bla CTX-M-17, which confer resistance to various cephalosporins in Enterobacteriaceae isolates from Vietnam.
Outbreak of extended-spectrum beta-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a French hospital.
The study identifies the extended-spectrum beta-lactamase VEB-1 in Acinetobacter baumannii for the first time, highlighting its role in multidrug resistance and the challenges in detecting ESBLs in this species.
IS1999 increases expression of the extended-spectrum beta-lactamase VEB-1 in Pseudomonas aeruginosa.
IS1999 increases the expression of the extended-spectrum beta-lactamase VEB-1 in Pseudomonas aeruginosa, leading to increased resistance to ceftazidime.
Functional and structural characterization of the genetic environment of an extended-spectrum beta-lactamase blaVEB gene from a Pseudomonas aeruginosa isolate obtained in India.
The study identifies and characterizes the blaVEB-1a gene, an extended-spectrum beta-lactamase, in a Pseudomonas aeruginosa isolate from India, highlighting its unique genetic environment and resistance mechanisms.
Outbreak of infection caused by Enterobacter cloacae producing the novel VEB-3 beta-lactamase in China.
Outbreak of infection caused by Enterobacter cloacae producing the novel VEB-3 beta-lactamase in China.
Outbreak of infection caused by Enterobacter cloacae producing the novel VEB-3 beta-lactamase in China.
Outbreak of infection caused by Enterobacter cloacae producing the novel VEB-3 beta-lactamase in China.
Detection of extended-spectrum beta-lactamases in clinical isolates of Pseudomonas aeruginosa.
The study identified blaVEB-3 as the most prevalent extended-spectrum beta-lactamase gene in Pseudomonas aeruginosa clinical isolates, demonstrating its role in conferring resistance to several beta-lactam antibiotics.
Emergence of PER-2 and VEB-1a in Acinetobacter baumannii Strains in the Americas.
The study reports the emergence of PER-2 and VEB-1a beta-lactamases in Acinetobacter baumannii strains in the Americas, along with the identification of blaOXA-58, a carbapenemase gene.
VEB-1 Extended-spectrum beta-lactamase-producing Acinetobacter baumannii, France.
The study identifies VEB-1 extended-spectrum beta-lactamase as a key factor in the resistance of Acinetobacter baumannii to various beta-lactam antibiotics, leading to a nationwide outbreak in France.
VEB-1 in Achromobacter xylosoxidans from cystic fibrosis patient, France.
The study reports the first identification of the VEB-1 extended-spectrum beta-lactamase in Achromobacter xylosoxidans from a cystic fibrosis patient, highlighting the potential clinical significance of this resistance mechanism.
RmtC 16S rRNA methyltransferase in Australia.
RmtC 16S rRNA methyltransferase in Australia.
RmtC 16S rRNA methyltransferase in Australia.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Increase in beta-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type beta-lactamases.
Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic.
The study identified the high prevalence of bla CTX-M genes in ESBL-producing E. coli and K. pneumoniae isolates in Thailand, highlighting the endemic nature of CTX-M-type ESBLs. It also reported the first detection of CTX-M-3, CTX-M-27, CTX-M-40, SHV-27, SHV-71, and SHV-75 in Thailand.
A blaVEB-1 variant, blaVEB-6, associated with repeated elements in a complex genetic structure.
The study identifies a novel blaVEB-6 variant in a Proteus mirabilis isolate, which confers resistance to ceftazidime, cefotaxime, and aztreonam.
A blaVEB-1 variant, blaVEB-6, associated with repeated elements in a complex genetic structure.
Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan.
The study identified various beta-lactamase genes, including bla IMP-1, bla IMP-8, bla OXA-58, bla VEB-3, and bla ADC, which confer resistance to beta-lactam antibiotics in Acinetobacter genospecies 3 isolates in Taiwan.
Diversity of clavulanic acid-inhibited extended-spectrum beta-lactamases in Aeromonas spp. from the Seine River, Paris, France.
The study identified various clavulanic acid-inhibited extended-spectrum beta-lactamases (ESBLs) in Aeromonas spp. from the Seine River, including blaVEB-1a, blaSHV-12, blaPER-1, blaPER-6, blaTLA-2, and blaGES-7, highlighting the diversity of ESBLs in aquatic environments.
Diversity of clavulanic acid-inhibited extended-spectrum β-lactamases in Aeromonas spp. from the Seine River, Paris, France., VEB-1 in Achromobacter xylosoxidans from cystic fibrosis patient, France., VEB-1-like extended-spectrum beta-lactamases in Pseudomonas aeruginosa, Kuwait.
Effective antibiotics in combination against extreme drug-resistant Pseudomonas aeruginosa with decreased susceptibility to polymyxin B.
The study identifies metallo-beta-lactamase genes (blaIMP and blaVIM) and other resistance genes (VEB-1 and OXA-10) in XDR-PA isolates, highlighting the need for combination therapies against these resistant strains.
Integrase-mediated recombination of the veb1 gene cassette encoding an extended-spectrum beta-lactamase.
The study shows that the veb1 gene cassette, encoding the extended-spectrum beta-lactamase VEB-1, has a low recombination efficiency due to the structure of its attC site. Modifying the veb1 attC site to resemble the more efficient aadB attC site significantly improved recombination efficiency.
Homology modeling and virtual screening approaches to identify potent inhibitors of VEB-1 beta-lactamase.
The study identifies four VEB-1 beta-lactamase inhibitors using homology modeling and virtual screening, highlighting the importance of targeting VEB-1, which confers resistance to ceftazidime, cefotaxime, and aztreonam.
beta-lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula.
The study identifies various beta-lactamase genes, including CTX-M-15, CTX-M-14, CTX-M-9, SHV-12, SHV-5, TEM-1, VEB-1, GES-1, GES-5, GES-11, PER-1, OXA-48, NDM-1, VIM-2, OXA-23, OXA-40, OXA-58, and OXA-181, which confer resistance to β-lactam antibiotics in Gram-negative pathogens from the Arabian Peninsula.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
NDM-1 Metallo-β-Lactamase and ArmA 16S rRNA methylase producing Providencia rettgeri clinical isolates in Nepal.
The study identifies multidrug-resistant Providencia rettgeri clinical isolates in Nepal carrying bla NDM-1, bla OXA-72, and armA genes, which confer resistance to carbapenems and aminoglycosides.
Antimicrobial resistance pattern and their beta-lactamase encoding genes among Pseudomonas aeruginosa strains isolated from cancer patients.
The study identified blaVIM-2, blaOXA-10, blaVEB-1, blaNDM, and blaIMP-1 as the most prevalent beta-lactamase genes in P. aeruginosa isolates from Egypt, contributing to resistance against imipenem and ceftazidime.
Antimicrobial Resistance Patterns and Prevalence of blaPER-1 and blaVEB-1 Genes Among ESBL-producing Pseudomonas aeruginosa Isolates in West of Iran.
The study identified blaPER-1 and blaVEB-1 genes as significant contributors to extended-spectrum beta-lactamase (ESBL) production in Pseudomonas aeruginosa isolates from western Iran, highlighting the high prevalence of multidrug-resistant strains.
Frequency of PER, VEB, SHV, TEM and CTX-M Genes in Resistant Strains of Pseudomonas aeruginosa Producing Extended Spectrum beta-lactamases.
The study identified blaTEM-116, blaVEB-1, and blaPER-1 as the most prevalent ESBL genes in Pseudomonas aeruginosa isolates from Zahedan, Iran, with blaTEM being 100% prevalent.
Characterization of Multidrug Resistant Extended-Spectrum Beta-Lactamase-Producing Escherichia coli among Uropathogens of Pediatrics in North of Iran.
The study identified TEM, SHV, CTX, and VEB beta-lactamase genes as the primary drivers of extended-spectrum beta-lactamase production in E. coli isolates from pediatric patients in northern Iran, with TEM being the most prevalent. These genes conferred resistance to various beta-lactam antibiotics.
Draft genome sequence of blaVeb-1, blaoxa-10 producing multi-drug resistant (MDR) Pseudomonas aeruginosa strain VRFPA09 recovered from bloodstream infection.
The study reports the draft genome sequence of MDR Pseudomonas aeruginosa strain VRFPA09, identifying several AMR genes including blaVeb-1, blaOXA-10, aadA1, aph(3')Iib, Sul1, CatB7, TetG, dfrB5, and fosA, which contribute to resistance against various antibiotics.
Identification of Novel VEB β-Lactamase Enzymes and Their Impact on Avibactam Inhibition.
Identification of Novel VEB β-Lactamase Enzymes and Their Impact on Avibactam Inhibition.
Identification of Novel VEB β-Lactamase Enzymes and Their Impact on Avibactam Inhibition.
Identification of Novel VEB β-Lactamase Enzymes and Their Impact on Avibactam Inhibition.
Identification of Novel VEB β-Lactamase Enzymes and Their Impact on Avibactam Inhibition.
Identification of Novel VEB β-Lactamase Enzymes and Their Impact on Avibactam Inhibition.
Presence of blaPER-1 and blaVEB-1 beta-lactamase genes among isolates of Pseudomonas aeruginosa from South West of Iran.
The study identified the presence of blaPER-1 and blaVEB-1 beta-lactamase genes among Pseudomonas aeruginosa isolates from ICU patients in South West Iran, contributing to resistance against ceftazidime and cefotaxime.
Significance of nucleic acid testing in diagnosis and treatment of post-neurosurgical meningitis caused by multidrug-resistant Acinetobacter baumannii: a case report.
The case report highlights the importance of molecular techniques in diagnosing post-neurosurgical meningitis caused by multidrug-resistant Acinetobacter baumannii, identifying the presence of VEB, NDM-1, IMP, and OXA-58 genes.
Detection of SGI1/PGI1 Elements and Resistance to Extended-Spectrum Cephalosporins in Proteae of Animal Origin in France.
The study identified several beta-lactamase genes, including blaVEB-6, blaCTX-M-1, blaCTX-M-15, blaCMY-2, and blaDHA-16, which confer resistance to extended-spectrum cephalosporins in Proteae isolates from animals in France.
Resistance to antimicrobial drugs in different surface waters and wastewaters of Guadeloupe.
The study identified several AMR genes including blaCTX-M, blaSHV, blaTEM, qnrB19, qnrB1, aac(6')-Ib-cr, VEB-1, CMY-2, and CMY-8 in Enterobacteriaceae isolates from surface waters and wastewaters in Guadeloupe. These genes conferred resistance to various antibiotics such as ceftazidime, cefotaxime, ampicillin, ciprofloxacin, gentamicin, and cefoxitin.
VEB-1 extended-spectrum beta-lactamase-producing multidrug-resistant Proteus mirabilis sepsis outbreak in a neonatal intensive care unit in India: clinical and diagnostic implications.
The study identifies VEB-1 extended-spectrum beta-lactamase as the primary resistance mechanism in multidrug-resistant Proteus mirabilis causing a sepsis outbreak in a neonatal intensive care unit in India.
Genetic Characterization of Broad-Host-Range IncQ Plasmids Harboring bla(VEB-18) in Vibrio Species.
Genetic Characterization of Broad-Host-Range IncQ Plasmids Harboring bla(VEB-18) in Vibrio Species.
Prevalence of ESBL-producing Pseudomonas aeruginosa isolates in Warsaw, Poland, detected by various phenotypic and genotypic methods.
The study identified three novel ESBL genes, blaGES-15, blaOXA-141, and blaOXA-142, along with several known ESBL genes in Pseudomonas aeruginosa isolates from Warsaw, Poland.
Distribution of the bla OXA , bla VEB-1 , and bla GES-1 genes and resistance patterns of ESBL-producing Pseudomonas aeruginosa isolated from hospitals in Tehran and Qazvin, Iran.
The study identified blaOXA-1, blaOXA-4, blaGES-1, and blaVEB-1 genes as prevalent in ESBL-producing Pseudomonas aeruginosa isolates from hospitals in Tehran and Qazvin, Iran, contributing to resistance against various beta-lactam antibiotics.
Genomics and Susceptibility Profiles of Extensively Drug-Resistant Pseudomonas aeruginosa Isolates from Spain.
The study identified various AMR genes and mutations in extensively drug-resistant Pseudomonas aeruginosa isolates from Spain, including beta-lactamases, aminoglycoside-modifying enzymes, and mutations in genes such as ampC, oprD, gyrA, parC, mexZ, and glpT, which contribute to resistance against multiple antibiotics.
Functional Repertoire of Antibiotic Resistance Genes in Antibiotic Manufacturing Effluents and Receiving Freshwater Sediments.
The study identified numerous antibiotic resistance genes (ARGs) in antibiotic manufacturing effluents and receiving sediments, highlighting the presence of both known and potentially novel resistance mechanisms. Key findings include the discovery of macrolide resistance genes such as hflx, msr(e), mph(e), mph(g), and mef(c), as well as sulfonamide resistance genes sul1 and sul2, and beta-lactamase genes like bla ges-1, bla veb-9, and bla cm y-10. Additionally, trimethoprim resistance genes dfr14, dfra1, and dfr17 were identified.
Identification and antimicrobial susceptibility of microorganisms isolated from severe corneal ulcers of dogs in Thailand.
The study identified methicillin-resistant Staphylococcus spp. carrying the mecA gene, and ESBL-producing isolates with bla CTX-M, bla VEB-1, and bla SHV genes. Staphylococci showed high resistance to fluoroquinolones and fusidic acid, while chloramphenicol remained effective against methicillin-resistant strains.
Multidrug-resistant Citrobacter freundii ST139 co-producing NDM-1 and CMY-152 from China.
The study identifies a multidrug-resistant Citrobacter freundii strain co-producing NDM-1 and CMY-152, along with other resistance genes such as bla VEB-3, bla TEM-1, qnrS1, and others, highlighting the complex resistance mechanisms in this isolate.
Co-production of AmpC and extended spectrum beta-lactamases in cephalosporin-resistant Acinetobacter baumannii in Egypt.
The study identifies the prevalence of extended-spectrum beta-lactamases (ESBLs) and AmpC beta-lactamases in cephalosporin-resistant Acinetobacter baumannii isolates in Egypt, highlighting the co-production of blaTEM, blaPER, blaSHV, blaVEB, and blaADC genes contributing to beta-lactam resistance.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
Evaluation of the Synergy of Ceftazidime-Avibactam in Combination with Meropenem, Amikacin, Aztreonam, Colistin, or Fosfomycin against Well-Characterized Multidrug-Resistant Klebsiella pneumoniae and Pseudomonas aeruginosa.
The study evaluated the synergy of ceftazidime-avibactam (CZA) in combination with other antibiotics against multidrug-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa. Several AMR genes, including blaKPC-2, blaKPC-3, blaCTX-M-15, and others, were identified as conferring resistance to CZA and other antibiotics.
Evaluation of in vitro activity of ceftazidime/avibactam and ceftolozane/tazobactam against MDR Pseudomonas aeruginosa isolates from Qatar.
The study evaluated the in vitro activity of ceftazidime/avibactam and ceftolozane/tazobactam against MDR Pseudomonas aeruginosa isolates from Qatar. It identified several beta-lactamase genes, including blaTEM-116, blaVEB-1a, blaCARB-3, blaVIM-2, blaPDC-2, blaPDC-3, blaPDC-5, blaPDC-7, blaOXA-4, blaOXA-10, and blaOXA-50, which contribute to resistance against these antibiotics.
Detection in two hospitals of transferable ceftazidime-avibactam resistance in Klebsiella pneumoniae due to a novel VEB beta-lactamase variant with a Lys234Arg substitution, Greece, 2019.
The study identifies a novel VEB-25 beta-lactamase variant with a Lys234Arg substitution in K. pneumoniae strains, which confers resistance to ceftazidime-avibactam.
Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019.
Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019.
Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019.
Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019.
Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019.
Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019.
Co-Occurrence of the bla (KPC-2) and Mcr-3.3 Gene in Aeromonas caviae SCAc2001 Isolated from Patients with Diarrheal Disease.
The study identifies multiple antimicrobial resistance genes in Aeromonas caviae SCAc2001, including blaKPC, mcr-3.3, and others, highlighting the potential public health risks posed by this strain.
Replication of the Salmonella Genomic Island 1 (SGI1) triggered by helper IncC conjugative plasmids promotes incompatibility and plasmid loss.
The study identifies the rep gene as essential for the replication of Salmonella Genomic Island 1 (SGI1) in the presence of IncC plasmids. The rep gene, encoding a putative replication initiator protein, is necessary for SGI1 replication, and its deletion leads to a significant reduction in SGI1 copy number.
Scarless Removal of Large Resistance Island AbaR Results in Antibiotic Susceptibility and Increased Natural Transformability in Acinetobacter baumannii.
The study shows that removing the AbaR resistance island from Acinetobacter baumannii restores antibiotic susceptibility and increases natural transformability. Several AMR genes within AbaR were identified, including aadB, aacC1, aphA1b, aacA, aadA1, strA, strB, blaVEB-1, blaOXA-10, sul1, dhfrI, dhfrX, tetA(A), tetA(G), cmlA1, cmlA5, cmlA9, catA1, arr-2, and sup.
Whole Genome Sequencing of Ceftolozane-Tazobactam and Ceftazidime-Avibactam Resistant Pseudomonas aeruginosa Isolated from a Blood Stream Infection Reveals VEB and Chromosomal Metallo-Beta Lactamases as Genetic Determinants: A Case Report.
The study identifies multiple AMR genes in a multidrug-resistant Pseudomonas aeruginosa strain, including beta-lactamases (blaVEB-9, blaOXA-10, blaOXA-50, blaPDC-11), aminoglycoside resistance genes (aph(3')-IIb, aac(6')-Il, ant(2'')-Ia), fluoroquinolone resistance gene (crpP), phenicol resistance gene (catB7), and tetracycline resistance gene (tet(A)).
Antimicrobial resistance pattern, genetic distribution of ESBL genes, biofilm-forming potential, and virulence potential of Pseudomonas aeruginosa isolated from the burn patients in Tehran Hospitals, Iran.
The study identified bla PER-1 and bla VEB-1 genes as the most prevalent ESBL-encoding genes in Pseudomonas aeruginosa isolates from burn patients in Tehran, Iran.
Acinetobacter baumannii Antibiotic Resistance Mechanisms.
The paper reviews various beta-lactamases and other resistance mechanisms in Acinetobacter baumannii, focusing on their roles in resistance to beta-lactams, aminoglycosides, and other antibiotics.
Screening of Antimicrobial Resistance Genes and Epidemiological Features in Hospital and Community-Associated Carbapenem-Resistant Pseudomonas aeruginosa Infections.
The study identified several carbapenem resistance genes, including blaVEB, blaPER, blaNDM, blaKPC, blaIMP, blaVIM, blaOXA-48, and blaOXA-23, in carbapenem-resistant Pseudomonas aeruginosa isolates.
Molecular detection of Extended-Spectrum beta-lactamases (ESBLs) and biofilm formation in uropathogen Klebsiella pneumoniae in Iran.
The study identified bla TEM and bla VEB genes as prevalent ESBLs in K. pneumoniae isolates, contributing to resistance against cefotaxime and tetracycline.
Geographic Patterns of Carbapenem-Resistant Pseudomonas aeruginosa in the Asia-Pacific Region: Results from the Antimicrobial Testing Leadership and Surveillance (ATLAS) Program, 2015-2019.
The study identified various carbapenemase genes, including blaVIM, blaNDM, blaVEB, blaIMP, blaGES, blaTEM, and blaKPC, in carbapenem-resistant Pseudomonas aeruginosa isolates from the Asia-Pacific region.
Whole genome sequencing of the multidrug-resistant Chryseobacterium indologenes isolated from a patient in Brazil.
The study identified multiple antibiotic resistance genes and mutations in a multidrug-resistant Chryseobacterium indologenes strain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and efflux pumps, contributing to resistance against various antibiotics.
High prevalence of bla(VEB), bla(GES) and bla(PER) genes in beta-lactam resistant clinical isolates of Pseudomonas aeruginosa.
The study identified the high prevalence of bla(VEB), bla(GES), and bla(PER) genes in beta-lactam-resistant Pseudomonas aeruginosa clinical isolates, highlighting their significant role in resistance to various beta-lactam antibiotics.
ESBL plasmids in Klebsiella pneumoniae: diversity, transmission and contribution to infection burden in the hospital setting.
The study identified 25 distinct ESBL plasmids, with Plasmid A carrying bla CTX-M-15 being the most prevalent and contributing significantly to the burden of ceftriaxone-resistant and multidrug-resistant infections in the hospital setting.
Whole-Genome Sequencing Reveals Diversity of Carbapenem-Resistant Pseudomonas aeruginosa Collected through CDC's Emerging Infections Program, United States, 2016-2018.
Whole-Genome Sequencing Reveals Diversity of Carbapenem-Resistant Pseudomonas aeruginosa Collected through CDC's Emerging Infections Program, United States, 2016-2018.
Emergence of a floR-carrying plasmid in extended spectrum β-lactamase (ESBL) producing Pasteurella aerogenes, isolated from an avian species in China.
The study identifies the first occurrence of the blaVEB gene in Pasteurellaceae and confirms its function as an ESBL. Additionally, a plasmid carrying the floR gene, which confers florfenicol resistance, was isolated from P. aerogenes.
Epidemiological links and antimicrobial resistance of clinical Salmonella enterica ST198 isolates: a nationwide microbial population genomic study in Switzerland.
The study identifies several AMR genes and mutations associated with ciprofloxacin resistance in Salmonella enterica ST198 isolates, including aac(3)-Id, aadA7, bla TEM-1b, sul1, tetA, qnrB1, qnrS1, bla CTX-M-14b, bla VEB-8, and bla OXA-48. Additionally, inactivating mutations in ramR and acrB were found to contribute to high-level ciprofloxacin resistance.
An ST131 clade and a phylogroup A clade bearing an O101-like O-antigen cluster predominate among bloodstream Escherichia coli isolates from South-West Nigeria hospitals.
The study identified several AMR genes and mutations in bloodstream E. coli isolates from South-West Nigeria, including bla CTX-M-15, dfrA, dfrB, and various quinolone resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Correlations among Antibiotic Resistance Genes, Mobile Genetic Elements and Microbial Communities in Municipal Sewage Treatment Plants Revealed by High-Throughput Sequencing.
The study identifies various tetracycline resistance genes (tetC, tetE, tetG, tetM, tetO, tetQ, tetW, tetX), sulfonamide resistance gene (sulI), aminoglycoside resistance genes (ant(2')-Ia, ant(3')-Ia, aph(6')-Id, aph(33')-Ib, aac(6')-Ib), beta-lactam resistance genes (blaGES, blaVEB), chloramphenicol resistance gene (catB3), MLS resistance genes (ereA, ermB), and multidrug resistance genes (acrB, mexB, mexF) in municipal sewage treatment plants, highlighting their association with mobile genetic elements and microbial communities.
Resistance to ceftazidime-avibactam in a KPC-2-producing Klebsiella pneumoniae caused by the extended-spectrum beta-lactamase VEB-25.
The study identifies VEB-25 as a novel extended-spectrum beta-lactamase responsible for resistance to ceftazidime-avibactam in a KPC-2-producing Klebsiella pneumoniae isolate.
Prevalence and molecular analysis of antibiotic resistance of Pseudomonas aeruginosa isolated from clinical and environmental specimens in Basra, Iraq.
The study identified several beta-lactamase genes, including bla SHV-2a, bla CTX-M-28, bla OXA-677, bla PER, and bla VEB-2, which contribute to multidrug resistance in Pseudomonas aeruginosa isolates from Basra, Iraq.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
Cefiderocol Treatment for Patients with Multidrug- and Carbapenem-Resistant Pseudomonas aeruginosa Infections in the Compassionate Use Program.
The study identified various beta-lactamase genes, including bla GES, bla VEB-9, bla PER-1, bla NDM-1, bla VIM-2, bla IMP-15, and bla IMP-18, as well as PDC variants like bla PDC-3 and bla PDC-19A, which contribute to resistance against ceftolozane-tazobactam and ceftazidime-avibactam in multidrug-resistant and carbapenem-resistant Pseudomonas aeruginosa isolates.
Prevalence and antimicrobial resistance profiles of Vibrio spp. and Enterococcus spp. in retail shrimp in Northern California.
The study identified 27 unique antimicrobial resistance genes (ARGs) in Vibrio isolates, including qnrVC6, dfrA31, dfrA6, and qnrVC1, which conferred resistance to various antibiotics such as cephalosporins, chloramphenicol, gentamicin, and tetracycline.
Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.
The study identified various AMR genes in multidrug-resistant Gram-negative pathogens, highlighting the prevalence of bla CTX-M-15, bla CMY-42, bla NDM-5, aadA, bla TEM-1B, bla OXA-232, bla NDM-1, rmtB, rmtC, bla VEB, bla VIM-2, aph(3'), strA/B, bla OXA-23, aph (3′), catB, dfrB, bla VIM-2, fosA, oqxA, oqxB, bla OXA-23, bla CARB, bla OXA-91, bla OXA-51, bla PAO, bla SHV, aph (3′)-Ib, aph (6)-Id, mphE, msrE, ermB, mphA, aadA, rmtB, qnrB, dfrA, sul1, sul2, and fosA7.
Neonatal Bloodstream Infection with Ceftazidime-Avibactam-Resistant bla(KPC-2)-Producing Klebsiella pneumoniae Carrying bla(VEB-25).
The study identifies bla(KPC-2) and bla(VEB-25) as resistance genes in a neonatal bloodstream infection caused by Klebsiella pneumoniae, highlighting the importance of molecular diagnostics in detecting novel resistance mechanisms.
Impact of acquired broad-spectrum beta-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam beta-lactamase inhibitors in Escherichia coli.
The study evaluates the impact of various beta-lactamases on the susceptibility of Escherichia coli to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and their combinations with beta-lactamase inhibitors avibactam and taniborbactam.
A Wohlfahrtiimonas chitiniclastica with a novel type of bla(VEB-1)-carrying plasmid isolated from a zebra in China.
The study reports the first genetic characterization of a novel blaVEB-1-carrying plasmid in Wohlfahrtiimonas chitiniclastica, which contains resistance genes blaVEB-1, aadB, aacA1, and tetA(H).
Genomic investigation unveils high-risk ESBL producing Enterobacteriaceae within a rural environmental water body.
The study identifies several AMR genes and mutations in ESBL-producing Enterobacteriaceae isolated from a rural environmental water body in India, highlighting the presence of multidrug-resistant strains with genes such as bla VEB-6, bla SHV-12, bla NDM-1, bla CTX-M, and mcr-9, along with mutations in ompK 36 and gyrA.
Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing.
The paper discusses the prevalence of antimicrobial resistance in Aeromonas species, highlighting the presence of various beta-lactamase genes such as blaTEM-24, blaIMP-19, blaVIM-4, blaKPC-2, blaNDM-1, blaVIM-2, blaOXA-48, blaIMP-13, blaGES-5, blaTEM-1, blaSHV-12, blaVEB-9, blaMOX, blaFOX, blaACC, and others. It also identifies genes like cphA, vat, mcr-3.41, mcr-7.1, sul, dfr, tetA, rsmA, and adeF associated with resistance to sulfonamides, trimethoprim, tetracycline, polymyxin, and other antibiotics. The study emphasizes the role of horizontal gene transfer and mobile genetic elements in the dissemination of these resistance genes.
Assessment of three antibiotic combination regimens against Gram-negative bacteria causing neonatal sepsis in low- and middle-income countries.
The study identifies multiple AMR genes and mutations in Gram-negative bacteria causing neonatal sepsis in LMICs, including ESBLs, carbapenemases, and aminoglycoside-modifying enzymes, highlighting the high prevalence of multidrug resistance and the need for effective antibiotic combinations.
Antimicrobial Susceptibility and Genetic Epidemiology of Extended-Spectrum β-Lactamase-Positive Enterobacterales Clinical Isolates in Central Poland.
The study identified the prevalence of extended-spectrum beta-lactamase (ESβL) genes, including bla CTX-M, bla SHV, bla TEM, and bla VEB, in Enterobacterales clinical isolates from central Poland. The most common ESβL gene was bla CTX-M, and multiple resistance genes were often co-present in isolates.
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape.
The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.
First detection of VEB-1 extended-spectrum beta-lactamase-producing Escherichia coli clinical isolate in Japan.
The study reports the first detection of the blaVEB-1 gene in a clinical isolate of Escherichia coli in Japan, highlighting the emergence of a human pathogenic E. coli strain carrying a plasmid-borne class 1 integron with multidrug resistance gene cassettes.
Cefepime-taniborbactam activity against antimicrobial-resistant clinical isolates of Enterobacterales and Pseudomonas aeruginosa: GEARS global surveillance programme 2018-22.
Cefepime-taniborbactam showed potent in vitro activity against Enterobacterales and P. aeruginosa, particularly effective against isolates with carbapenemase genes such as blaIMP, blaNDM, and blaVIM, as well as those with mutations in ftsI, ompK35, and ompK36.
Genomic Insights into Vietnamese Extended-Spectrum beta-lactamase-9-Producing Extensively Drug-Resistant Pseudomonas aeruginosa Isolates Belonging to the High-Risk Clone ST357 Obtained from Bulgarian Intensive Care Unit Patients.
The study identified multiple AMR genes, including blaVEB-9, blaPDC-3, blaOXA-10, blaOXA-50, and others, in two extensively drug-resistant Pseudomonas aeruginosa isolates from Bulgaria. These genes conferred resistance to various antibiotics, including β-lactams, aminoglycosides, and fluoroquinolones.
Molecular epidemiology of beta-lactamases in ceftriaxone-resistant Enterobacterales bloodstream infections in the mid-Atlantic United States.
The study identified various beta-lactamase genes including bla CTX-M, bla SHV, bla OXY, bla VEB, bla CMY-59, and bla DHA-1 in ceftriaxone-resistant Enterobacterales. Additionally, mutations in the promoter or attenuator regions of the c-ampC gene in E. coli were investigated, but they did not significantly contribute to ceftriaxone resistance.
Genomic analysis of Enterobacter cloacae complex from Southern Thailand reveals insights into multidrug resistance genotypes and genetic diversity.
The study identified multiple antimicrobial resistance genes in Enterobacter cloacae complex isolates from Southern Thailand, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and efflux pumps. Notably, the mcr-9 gene was found to confer colistin resistance.
Rapid prediction of carbapenemases in Pseudomonas aeruginosa by imipenem/relebactam and MALDI-TOF MS.
The study characterizes various carbapenemase genes such as blaIMP-13, blaIMP-94, blaNDM-1, blaNDM-5, blaNDM-7, blaNDM-23, blaVIM-1, blaVIM-2, blaVIM-20, blaKPC-2, blaKPC-3, blaGES-1, blaGES-5, blaGES-7, blaGES-20, blaPER-1, blaVEB-1, blaCTX-M-15, blaCTX-M-9, blaSHV-12, blaFOX-4, blaCMY-2, blaDHA-1, blaOXA-2, blaOXA-10, blaOXA-14, blaOXA-15, and blaOXA-48 in Pseudomonas aeruginosa using MALDI-TOF MS hydrolysis assays.
Evaluation of QuickMIC system for rapid antimicrobial susceptibility testing of Gram-negative pathogens from positive blood cultures, including strains producing extended-spectrum β-lactamases and carbapenemases.
The study evaluated the QuickMIC system for rapid antimicrobial susceptibility testing of Gram-negative pathogens, including strains producing extended-spectrum β-lactamases (ESBLs) and carbapenemases. It identified several β-lactamase genes such as bla CTX-M, bla KPC, bla NDM, bla VIM, bla OXA-23-like, bla FIM, and bla VEB, which confer resistance to various beta-lactam antibiotics.
Antibiotics Resistance Profile of Clinical Isolates of Pseudomonas aeruginosa Obtained from Farwaniya Hospital in Kuwait Using Phenotypic and Molecular Methods.
The study identified blaVEB, blaVIM, aac(6')-Ib, and qnrS as the most prevalent resistance genes in MDR P. aeruginosa isolates. Mutations in gyrA (Thr83Ile) and parC (Ser87Leu) were strongly associated with fluoroquinolone resistance.
Broad spectrum of β-lactamase coverage and potent antimicrobial activity of xeruborbactam in combination with meropenem against carbapenemase-producing Enterobacterales, including strains resistant to new β-lactam/β-lactamase inhibitor combinations.
Xeruborbactam in combination with meropenem shows potent activity against carbapenemase-producing Enterobacterales, including strains resistant to other β-lactam/β-lactamase inhibitor combinations. Specific β-lactamases like blaIMP-23 and blaSPM-1 were identified as resistant to xeruborbactam.
In vitro activity of cefiderocol against nosocomial Acinetobacter baumannii.
The study assessed the in vitro activity of cefiderocol against multidrug-resistant Acinetobacter baumannii isolates and found that cefiderocol exhibited high efficacy, with very low resistance rates. However, the presence of various beta-lactamase genes, including bla OXA-23G, bla OXA-24G, bla OXA-48G, bla OXA-58G, bla VEB, bla PER, bla GES, bla KPC, bla NDM, bla VIM, bla IMP, and bla IMI, was associated with resistance to other antibiotics.
Whole-genome sequencing reveals resistance mechanisms and molecular epidemiology of carbapenem-resistant Pseudomonas aeruginosa bloodstream infections.
The study identified oprD mutations and efflux pumps hyperexpression as dominant drivers of carbapenem resistance in CRPA strains, with carbapenemase emerging as a clinically significant pathway.
Clonal dissemination of carbapenem-resistant ST477 Klebsiella michiganensis co-producing NDM-1, SFO-1, and VEB-3 in a Chinese hospital.
The study identifies the clonal dissemination of carbapenem-resistant ST477 Klebsiella michiganensis co-producing NDM-1, SFO-1, and VEB-3 in a Chinese hospital, highlighting the role of a self-transmissible plasmid in the spread of these resistance genes.
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