Browse AMR Genes

Gene Information

Gene Name: blaVIM
Allele: blaVIM-20
Encodes: subclass B1 metallo-beta-lactamase VIM-20
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: GQ414736.1
Protein Accession: ACV13198.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-20
Encodes: subclass B1 metallo-beta-lactamase VIM-20
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: GQ414736.1
Protein Accession: ACV13198.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-20
Encodes: subclass B1 metallo-beta-lactamase VIM-20, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: GQ414736.1
Protein Accession: ACV13198.1
Notes: Subclass B1, ARO:3002290

Gene Information

Gene Name: blaVIM
Allele: blaVIM-25
Encodes: subclass B1 metallo-beta-lactamase VIM-25
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Proteus mirabilis
Sequence Accession: HM750249.1
Protein Accession: ADO50679.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-25
Encodes: subclass B1 metallo-beta-lactamase VIM-25
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Proteus mirabilis
Sequence Accession: HM750249.1
Protein Accession: ADO50679.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-25
Encodes: subclass B1 metallo-beta-lactamase VIM-25, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Proteus mirabilis
Sequence Accession: HM750249.1
Protein Accession: ADO50679.1
Notes: Subclass B1, ARO:3002295

Gene Information

Gene Name: blaVIM
Allele: blaVIM-32
Encodes: subclass B1 metallo-beta-lactamase VIM-32
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella oxytoca
Sequence Accession: JN676230.2
Protein Accession: AEZ49857.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-32
Encodes: subclass B1 metallo-beta-lactamase VIM-32
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella oxytoca
Sequence Accession: JN676230.2
Protein Accession: AEZ49857.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-32
Encodes: subclass B1 metallo-beta-lactamase VIM-32, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella oxytoca
Sequence Accession: JN676230.2
Protein Accession: AEZ49857.1
Notes: Subclass B1, ARO:3002302

Gene Information

Gene Name: blaVIM
Allele: blaVIM-40
Encodes: subclass B1 metallo-beta-lactamase VIM-40
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: HG934765.1
Protein Accession: CDN33428.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-40
Encodes: subclass B1 metallo-beta-lactamase VIM-40
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: HG934765.1
Protein Accession: CDN33428.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-40
Encodes: subclass B1 metallo-beta-lactamase VIM-40
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: HG934765.1
Protein Accession: CDN33428.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-41
Encodes: subclass B1 metallo-beta-lactamase VIM-41
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP771862.1
Protein Accession: AKQ98358.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-41
Encodes: subclass B1 metallo-beta-lactamase VIM-41
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP771862.1
Protein Accession: AKQ98358.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-41
Encodes: subclass B1 metallo-beta-lactamase VIM-41
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP771862.1
Protein Accession: AKQ98358.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-42
Encodes: subclass B1 metallo-beta-lactamase VIM-42
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: KP071470.1
Protein Accession: AJP08641.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-42
Encodes: subclass B1 metallo-beta-lactamase VIM-42
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: KP071470.1
Protein Accession: AJP08641.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-42
Encodes: subclass B1 metallo-beta-lactamase VIM-42, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: KP071470.1
Protein Accession: AJP08641.1
Notes: Subclass B1, ARO:3003178

Gene Information

Gene Name: blaVIM
Allele: blaVIM-43
Encodes: subclass B1 metallo-beta-lactamase VIM-43
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP096412.1
Protein Accession: AJP67511.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-43
Encodes: subclass B1 metallo-beta-lactamase VIM-43
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP096412.1
Protein Accession: AJP67511.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-43
Encodes: subclass B1 metallo-beta-lactamase VIM-43, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP096412.1
Protein Accession: AJP67511.1
Notes: Subclass B1, ARO:3003179

Gene Information

Gene Name: blaVIM
Allele: blaVIM-44
Encodes: subclass B1 metallo-beta-lactamase VIM-44
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP681696.1
Protein Accession: AKO63212.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-44
Encodes: subclass B1 metallo-beta-lactamase VIM-44
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP681696.1
Protein Accession: AKO63212.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-44
Encodes: subclass B1 metallo-beta-lactamase VIM-44
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP681696.1
Protein Accession: AKO63212.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-45
Encodes: subclass B1 metallo-beta-lactamase VIM-45
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP681695.1
Protein Accession: AKO63211.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-45
Encodes: subclass B1 metallo-beta-lactamase VIM-45
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP681695.1
Protein Accession: AKO63211.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-45
Encodes: subclass B1 metallo-beta-lactamase VIM-45
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP681695.1
Protein Accession: AKO63211.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-46
Encodes: subclass B1 metallo-beta-lactamase VIM-46
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP749829.1
Protein Accession: AKQ98357.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-46
Encodes: subclass B1 metallo-beta-lactamase VIM-46
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP749829.1
Protein Accession: AKQ98357.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-46
Encodes: subclass B1 metallo-beta-lactamase VIM-46
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KP749829.1
Protein Accession: AKQ98357.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-47
Encodes: subclass B1 metallo-beta-lactamase VIM-47
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KT954134.1
Protein Accession: ALK87206.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-47
Encodes: subclass B1 metallo-beta-lactamase VIM-47
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KT954134.1
Protein Accession: ALK87206.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-47
Encodes: subclass B1 metallo-beta-lactamase VIM-47
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KT954134.1
Protein Accession: ALK87206.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-48
Encodes: subclass B1 metallo-beta-lactamase VIM-48
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Citrobacter cronae
Sequence Accession: KT964061.1
Protein Accession: ALM96779.1
Notes: ARO:3005496

Gene Information

Gene Name: blaVIM
Allele: blaVIM-48
Encodes: subclass B1 metallo-beta-lactamase VIM-48
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Citrobacter cronae
Sequence Accession: KT964061.1
Protein Accession: ALM96779.1
Notes: ARO:3005496

Gene Information

Gene Name: blaVIM
Allele: blaVIM-49
Encodes: subclass B1 metallo-beta-lactamase VIM-49
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KU663374.1
Protein Accession: AMD11802.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-49
Encodes: subclass B1 metallo-beta-lactamase VIM-49
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KU663374.1
Protein Accession: AMD11802.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-49
Encodes: subclass B1 metallo-beta-lactamase VIM-49
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KU663374.1
Protein Accession: AMD11802.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-50
Encodes: subclass B1 metallo-beta-lactamase VIM-50
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KU663375.1
Protein Accession: AMD11803.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-50
Encodes: subclass B1 metallo-beta-lactamase VIM-50
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KU663375.1
Protein Accession: AMD11803.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-50
Encodes: subclass B1 metallo-beta-lactamase VIM-50
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KU663375.1
Protein Accession: AMD11803.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-51
Encodes: subclass B1 metallo-beta-lactamase VIM-51
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: KU746270.1
Protein Accession: AMK97465.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-51
Encodes: subclass B1 metallo-beta-lactamase VIM-51
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: KU746270.1
Protein Accession: AMK97465.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-51
Encodes: subclass B1 metallo-beta-lactamase VIM-51
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: KU746270.1
Protein Accession: AMK97465.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-52
Encodes: subclass B1 metallo-beta-lactamase VIM-52
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: KX349731.1
Protein Accession: ANI25016.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-52
Encodes: subclass B1 metallo-beta-lactamase VIM-52
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: KX349731.1
Protein Accession: ANI25016.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-52
Encodes: subclass B1 metallo-beta-lactamase VIM-52
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: KX349731.1
Protein Accession: ANI25016.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-53
Encodes: subclass B1 metallo-beta-lactamase VIM-53
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KX788872.1
Protein Accession: AOP17664.1
Notes: ARO:3005501

Gene Information

Gene Name: blaVIM
Allele: blaVIM-53
Encodes: subclass B1 metallo-beta-lactamase VIM-53
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KX788872.1
Protein Accession: AOP17664.1
Notes: ARO:3005501

Gene Information

Gene Name: blaVIM
Allele: blaVIM-54
Encodes: subclass B1 metallo-beta-lactamase VIM-54
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia marcescens
Sequence Accession: KY508061.1
Protein Accession: APY16324.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-54
Encodes: subclass B1 metallo-beta-lactamase VIM-54
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia marcescens
Sequence Accession: KY508061.1
Protein Accession: APY16324.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-54
Encodes: subclass B1 metallo-beta-lactamase VIM-54
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia marcescens
Sequence Accession: KY508061.1
Protein Accession: APY16324.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-55
Encodes: subclass B1 metallo-beta-lactamase VIM-55
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: MG552720.1
Protein Accession: ATY69436.1
Notes: ARO:3005503

Gene Information

Gene Name: blaVIM
Allele: blaVIM-55
Encodes: subclass B1 metallo-beta-lactamase VIM-55
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: MG552720.1
Protein Accession: ATY69436.1
Notes: ARO:3005503

Gene Information

Gene Name: blaVIM
Allele: blaVIM-56
Encodes: subclass B1 metallo-beta-lactamase VIM-56
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Citrobacter freundii
Sequence Accession: MG834535.1
Protein Accession: AUT30820.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-56
Encodes: subclass B1 metallo-beta-lactamase VIM-56
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Citrobacter freundii
Sequence Accession: MG834535.1
Protein Accession: AUT30820.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-56
Encodes: subclass B1 metallo-beta-lactamase VIM-56
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Citrobacter freundii
Sequence Accession: MG834535.1
Protein Accession: AUT30820.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-57
Encodes: subclass B1 metallo-beta-lactamase VIM-57
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Escherichia coli
Sequence Accession: MH450217.1
Protein Accession: AWU66465.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-57
Encodes: subclass B1 metallo-beta-lactamase VIM-57
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Escherichia coli
Sequence Accession: MH450217.1
Protein Accession: AWU66465.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-57
Encodes: subclass B1 metallo-beta-lactamase VIM-57
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Escherichia coli
Sequence Accession: MH450217.1
Protein Accession: AWU66465.1
Notes: Subclass B1

Gene Information

Gene Name: blaVIM
Allele: blaVIM-58
Encodes: subclass B1 metallo-beta-lactamase VIM-58
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: MH479908.1
Protein Accession: AWV82454.1
Notes: ARO:3005506

Gene Information

Gene Name: blaVIM
Allele: blaVIM-58
Encodes: subclass B1 metallo-beta-lactamase VIM-58
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: MH479908.1
Protein Accession: AWV82454.1
Notes: ARO:3005506

Gene Information

Gene Name: blaVIM
Allele: blaVIM-59
Encodes: subclass B1 metallo-beta-lactamase VIM-59
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Citrobacter freundii
Sequence Accession: MH548439.1
Protein Accession: AWY71041.1
Notes: ARO:3005507

Gene Information

Gene Name: blaVIM
Allele: blaVIM-59
Encodes: subclass B1 metallo-beta-lactamase VIM-59
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Citrobacter freundii
Sequence Accession: MH548439.1
Protein Accession: AWY71041.1
Notes: ARO:3005507

Gene Information

Gene Name: blaVIM
Allele: blaVIM-60
Encodes: subclass B1 metallo-beta-lactamase VIM-60
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: LC405957.1
Protein Accession: BBF24895.1
Notes: ARO:3005508

Gene Information

Gene Name: blaVIM
Allele: blaVIM-60
Encodes: subclass B1 metallo-beta-lactamase VIM-60
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: LC405957.1
Protein Accession: BBF24895.1
Notes: ARO:3005508

Gene Information

Gene Name: blaVIM
Allele: blaVIM-61
Encodes: subclass B1 metallo-beta-lactamase VIM-61
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MK098862.1
Protein Accession: AYP70145.1
Notes: ARO:3005509

Gene Information

Gene Name: blaVIM
Allele: blaVIM-61
Encodes: subclass B1 metallo-beta-lactamase VIM-61
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MK098862.1
Protein Accession: AYP70145.1
Notes: ARO:3005509

Gene Information

Gene Name: blaVIM
Allele: blaVIM-62
Encodes: subclass B1 metallo-beta-lactamase VIM-62
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas putida
Sequence Accession: MG717459.1
Protein Accession: AXH79879.1
Notes: ARO:3005510

Gene Information

Gene Name: blaVIM
Allele: blaVIM-62
Encodes: subclass B1 metallo-beta-lactamase VIM-62
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas putida
Sequence Accession: MG717459.1
Protein Accession: AXH79879.1
Notes: ARO:3005510

Gene Information

Gene Name: blaVIM
Allele: blaVIM-63
Encodes: subclass B1 metallo-beta-lactamase VIM-63
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MK780742.1
Protein Accession: QCB64361.1
Notes: ARO:3005511

Gene Information

Gene Name: blaVIM
Allele: blaVIM-63
Encodes: subclass B1 metallo-beta-lactamase VIM-63
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MK780742.1
Protein Accession: QCB64361.1
Notes: ARO:3005511

Gene Information

Gene Name: blaVIM
Allele: blaVIM-64
Encodes: subclass B1 metallo-beta-lactamase VIM-64
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: MK807022.1
Protein Accession: QCE31562.1
Notes: ARO:3005512

Gene Information

Gene Name: blaVIM
Allele: blaVIM-64
Encodes: subclass B1 metallo-beta-lactamase VIM-64
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: MK807022.1
Protein Accession: QCE31562.1
Notes: ARO:3005512

Gene Information

Gene Name: blaVIM
Allele: blaVIM-65
Encodes: subclass B1 metallo-beta-lactamase VIM-65
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Citrobacter freundii
Sequence Accession: MK807023.1
Protein Accession: QCE31563.1
Notes: ARO:3005513

Gene Information

Gene Name: blaVIM
Allele: blaVIM-65
Encodes: subclass B1 metallo-beta-lactamase VIM-65
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Citrobacter freundii
Sequence Accession: MK807023.1
Protein Accession: QCE31563.1
Notes: ARO:3005513

Gene Information

Gene Name: blaVIM
Allele: blaVIM-66
Encodes: subclass B1 metallo-beta-lactamase VIM-66
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: LC467967.1
Protein Accession: BBJ06445.1
Notes: ARO:3005514

Gene Information

Gene Name: blaVIM
Allele: blaVIM-66
Encodes: subclass B1 metallo-beta-lactamase VIM-66
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: LC467967.1
Protein Accession: BBJ06445.1
Notes: ARO:3005514

Gene Information

Gene Name: blaVIM
Allele: blaVIM-67
Encodes: subclass B1 metallo-beta-lactamase VIM-67
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Enterobacter hormaechei
Sequence Accession: MN166907.1
Protein Accession: QDM39451.1
Notes: ARO:3005515

Gene Information

Gene Name: blaVIM
Allele: blaVIM-67
Encodes: subclass B1 metallo-beta-lactamase VIM-67
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Enterobacter hormaechei
Sequence Accession: MN166907.1
Protein Accession: QDM39451.1
Notes: ARO:3005515

Gene Information

Gene Name: blaVIM
Allele: blaVIM-68
Encodes: subclass B1 metallo-beta-lactamase VIM-68
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Providencia stuartii
Sequence Accession: MN267702.1
Protein Accession: QED08960.1
Notes: ARO:3005516

Gene Information

Gene Name: blaVIM
Allele: blaVIM-68
Encodes: subclass B1 metallo-beta-lactamase VIM-68
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Providencia stuartii
Sequence Accession: MN267702.1
Protein Accession: QED08960.1
Notes: ARO:3005516

Gene Information

Gene Name: blaVIM
Allele: blaVIM-69
Encodes: subclass B1 metallo-beta-lactamase VIM-69
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: SGUI01000104.1
Protein Accession: RZN95180.1
Notes: ARO:3005517

Gene Information

Gene Name: blaVIM
Allele: blaVIM-69
Encodes: subclass B1 metallo-beta-lactamase VIM-69
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: SGUI01000104.1
Protein Accession: RZN95180.1
Notes: ARO:3005517

Gene Information

Gene Name: blaVIM
Allele: blaVIM-70
Encodes: subclass B1 metallo-beta-lactamase VIM-70
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MN920417.1
Protein Accession: QHI08146.1
Notes: ARO:3005518

Gene Information

Gene Name: blaVIM
Allele: blaVIM-70
Encodes: subclass B1 metallo-beta-lactamase VIM-70
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MN920417.1
Protein Accession: QHI08146.1
Notes: ARO:3005518

Gene Information

Gene Name: blaVIM
Allele: blaVIM-71
Encodes: subclass B1 metallo-beta-lactamase VIM-71
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Vibrio alginolyticus
Sequence Accession: MT588301.1
Protein Accession: QKV50751.1
Notes: ARO:3005519

Gene Information

Gene Name: blaVIM
Allele: blaVIM-71
Encodes: subclass B1 metallo-beta-lactamase VIM-71
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Vibrio alginolyticus
Sequence Accession: MT588301.1
Protein Accession: QKV50751.1
Notes: ARO:3005519

Gene Information

Gene Name: blaVIM
Allele: blaVIM-72
Encodes: subclass B1 metallo-beta-lactamase VIM-72
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MT872420.1
Protein Accession: QNG62079.1
Notes: ARO:3005520

Gene Information

Gene Name: blaVIM
Allele: blaVIM-72
Encodes: subclass B1 metallo-beta-lactamase VIM-72
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MT872420.1
Protein Accession: QNG62079.1
Notes: ARO:3005520

Gene Information

Gene Name: blaVIM
Allele: blaVIM-73
Encodes: subclass B1 metallo-beta-lactamase VIM-73
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MT872421.1
Protein Accession: QNG62080.1
Notes: ARO:3005521

Gene Information

Gene Name: blaVIM
Allele: blaVIM-73
Encodes: subclass B1 metallo-beta-lactamase VIM-73
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MT872421.1
Protein Accession: QNG62080.1
Notes: ARO:3005521

Gene Information

Gene Name: blaVIM
Allele: blaVIM-74
Encodes: subclass B1 metallo-beta-lactamase VIM-74
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MW811442.1
Protein Accession: QTG68659.1
Notes: ARO:3007804

Gene Information

Gene Name: blaVIM
Allele: blaVIM-74
Encodes: subclass B1 metallo-beta-lactamase VIM-74, VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: MW811442.1
Protein Accession: QTG68659.1
Notes: ARO:3007804

Gene Information

Gene Name: blaVIM
Allele: blaVIM-75
Encodes: subclass B1 metallo-beta-lactamase VIM-75
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Proteus mirabilis
Sequence Accession: MZ748327.1
Protein Accession: QYZ89894.1
Notes: ARO:3007812

Gene Information

Gene Name: blaVIM
Allele: blaVIM-75
Encodes: subclass B1 metallo-beta-lactamase VIM-75, VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Proteus mirabilis
Sequence Accession: MZ748327.1
Protein Accession: QYZ89894.1
Notes: ARO:3007812

Gene Information

Gene Name: blaVIM
Allele: blaVIM-76
Encodes: subclass B1 metallo-beta-lactamase VIM-76
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: LC648428.1
Protein Accession: BDA82255.1
Notes: ARO:3007813

Gene Information

Gene Name: blaVIM
Allele: blaVIM-76
Encodes: subclass B1 metallo-beta-lactamase VIM-76, VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: LC648428.1
Protein Accession: BDA82255.1
Notes: ARO:3007813

Gene Information

Gene Name: blaVIM
Allele: blaVIM-78
Encodes: subclass B1 metallo-beta-lactamase VIM-78
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Proteus mirabilis
Sequence Accession: OK180983.1
Protein Accession: UBK22127.1
Notes: ARO:3007815

100

Gene Information

Gene Name: blaVIM
Allele: blaVIM-78
Encodes: subclass B1 metallo-beta-lactamase VIM-78, VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Proteus mirabilis
Sequence Accession: OK180983.1
Protein Accession: UBK22127.1
Notes: ARO:3007815

101

Gene Information

Gene Name: blaVIM
Allele: blaVIM-79
Encodes: subclass B1 metallo-beta-lactamase VIM-79
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Klebsiella oxytoca
Sequence Accession: OK217280.1
Protein Accession: UBL87558.1
Notes: ARO:3007816

102

Gene Information

Gene Name: blaVIM
Allele: blaVIM-79
Encodes: subclass B1 metallo-beta-lactamase VIM-79, VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Klebsiella oxytoca
Sequence Accession: OK217280.1
Protein Accession: UBL87558.1
Notes: ARO:3007816

103

Gene Information

Gene Name: blaVIM
Allele: blaVIM-80
Encodes: subclass B1 metallo-beta-lactamase VIM-80
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JACTAE010000183.1
Protein Accession: MBC9045152.1
Notes: ARO:3007817

104

Gene Information

Gene Name: blaVIM
Allele: blaVIM-80
Encodes: subclass B1 metallo-beta-lactamase VIM-80, VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JACTAE010000183.1
Protein Accession: MBC9045152.1
Notes: ARO:3007817

105

Gene Information

Gene Name: blaVIM
Allele: blaVIM-81
Encodes: subclass B1 metallo-beta-lactamase VIM-81
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: ON059758.1
Protein Accession: UNZ81762.1
Notes: ARO:3007818

106

Gene Information

Gene Name: blaVIM
Allele: blaVIM-81
Encodes: subclass B1 metallo-beta-lactamase VIM-81, VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: ON059758.1
Protein Accession: UNZ81762.1
Notes: ARO:3007818

107

Gene Information

Gene Name: blaVIM
Allele: blaVIM-82
Encodes: subclass B1 metallo-beta-lactamase VIM-82
Source Database: Reference Gene Catalog
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: CAKNDP010000008.1

108

Gene Information

Gene Name: blaVIM
Allele: blaVIM-84
Encodes: subclass B1 metallo-beta-lactamase VIM-84
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: ON688661.1
Protein Accession: UWQ12890.1
Notes: ARO:3007821

109

Gene Information

Gene Name: blaVIM
Allele: blaVIM-84
Encodes: subclass B1 metallo-beta-lactamase VIM-84, VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: ON688661.1
Protein Accession: UWQ12890.1
Notes: ARO:3007821

110

Gene Information

Gene Name: blaVIM
Allele: blaVIM-85
Encodes: subclass B1 metallo-beta-lactamase VIM-85
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: ON688662.1
Protein Accession: UWQ12891.1
Notes: ARO:3007822

111

Gene Information

Gene Name: blaVIM
Allele: blaVIM-85
Encodes: subclass B1 metallo-beta-lactamase VIM-85, VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: ON688662.1
Protein Accession: UWQ12891.1
Notes: ARO:3007822

112

Gene Information

Gene Name: blaVIM
Allele: blaVIM-87
Encodes: subclass B1 metallo-beta-lactamase VIM-87
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: ABPYXB010000003.1
Protein Accession: EME7055635.1
Notes: ARO:3007824

113

Gene Information

Gene Name: blaVIM
Allele: blaVIM-87
Encodes: subclass B1 metallo-beta-lactamase VIM-87, VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: ABPYXB010000003.1
Protein Accession: EME7055635.1
Notes: ARO:3007824

114

Gene Information

Gene Name: blaVIM
Allele: blaVIM-88
Encodes: subclass B1 metallo-beta-lactamase VIM-88
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: PQ394569.1
Protein Accession: XHO32912.1
Notes: ARO:3009092

115

Gene Information

Gene Name: blaVIM
Allele: blaVIM-88
Encodes: subclass B1 metallo-beta-lactamase VIM-88, VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: PQ394569.1
Protein Accession: XHO32912.1
Notes: ARO:3009092

116

Gene Information

Gene Name: blaVIM
Allele: blaVIM-89
Encodes: subclass B1 metallo-beta-lactamase VIM-89
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PQ394570.1
Protein Accession: XHO32913.1
Notes: ARO:3009093

117

Gene Information

Gene Name: blaVIM
Allele: blaVIM-89
Encodes: subclass B1 metallo-beta-lactamase VIM-89, VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PQ394570.1
Protein Accession: XHO32913.1
Notes: ARO:3009093

118

Gene Information

Gene Name: blaVIM
Allele: blaVIM-90
Encodes: subclass B1 metallo-beta-lactamase VIM-90
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PQ394571.1
Protein Accession: XHO32914.1
Notes: ARO:3009094

119

Gene Information

Gene Name: blaVIM
Allele: blaVIM-90
Encodes: subclass B1 metallo-beta-lactamase VIM-90, VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PQ394571.1
Protein Accession: XHO32914.1
Notes: ARO:3009094

120

Gene Information

Gene Name: blaVIM
Allele: blaVIM-91
Encodes: subclass B1 metallo-beta-lactamase VIM-91
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JBHOJN010000016.1
Protein Accession: MFC1252596.1
Notes: ARO:3009095

121

Gene Information

Gene Name: blaVIM
Allele: blaVIM-91
Encodes: subclass B1 metallo-beta-lactamase VIM-91, VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JBHOJN010000016.1
Protein Accession: MFC1252596.1
Notes: ARO:3009095

122

Gene Information

Gene Name: blaVIM
Allele: blaVIM-92
Encodes: subclass B1 metallo-beta-lactamase VIM-92
Source Database: Reference Gene Catalog
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PQ563311.1
Protein Accession: XKB79100.1

123

Gene Information

Gene Name: blaVIM
Allele: blaVIM-93
Encodes: subclass B1 metallo-beta-lactamase VIM-93
Source Database: Reference Gene Catalog
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Enterobacter cloacae complex sp.
Sequence Accession: PQ881805.1
Protein Accession: XNX55853.1

124

Gene Information

Gene Name: blaVIM
Allele: blaVIM-94
Encodes: subclass B1 metallo-beta-lactamase VIM-94
Source Database: Reference Gene Catalog
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PV075094.1
Protein Accession: XOU30559.1

125

Gene Information

Gene Name: blaVIM
Allele: blaVIM-95
Encodes: subclass B1 metallo-beta-lactamase VIM-95
Source Database: Reference Gene Catalog
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PV088245.1
Protein Accession: XPD12777.1

126

Gene Information

Gene Name: blaVIM
Allele: blaVIM-96
Encodes: subclass B1 metallo-beta-lactamase VIM-96
Source Database: Reference Gene Catalog
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Klebsiella variicola subsp. variicola
Sequence Accession: PX096848.1
Protein Accession: XYW63392.1

127

Gene Information

Gene Name: blaVIM
Allele: blaVIM-97
Encodes: subclass B1 metallo-beta-lactamase VIM-97
Source Database: Reference Gene Catalog
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: PZ139268.1
Protein Accession: YDO78656.1

128

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF317511.1
Protein Accession: AAN63496.1
Notes: ARO:3002271

129

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: EF614235.1
Protein Accession: ABR10840.1
Notes: ARO:3002272

130

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AM087411.1
Protein Accession: CAJ32502.1
Notes: ARO:3002274

131

Gene Information

Gene Name: blaVIM
Allele: blaVIM-40
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: NG_050368.1
Protein Accession: WP_063865190.1
Notes: ARO:3002310

132

Gene Information

Gene Name: blaVIM
Allele: blaVIM-41
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_050369.1
Protein Accession: WP_063865191.1
Notes: ARO:3002311

133

Gene Information

Gene Name: blaVIM
Allele: blaVIM-44
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_050372.1
Protein Accession: WP_063865194.1
Notes: ARO:3003660

134

Gene Information

Gene Name: blaVIM
Allele: blaVIM-45
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_050373.1
Protein Accession: WP_063865195.1
Notes: ARO:3003661

135

Gene Information

Gene Name: blaVIM
Allele: blaVIM-46
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_050374.1
Protein Accession: WP_063865196.1
Notes: ARO:3003662

136

Gene Information

Gene Name: blaVIM
Allele: blaVIM-47
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_050375.1
Protein Accession: WP_063865197.1
Notes: ARO:3005495

137

Gene Information

Gene Name: blaVIM
Allele: blaVIM-48
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Citrobacter cronae
Sequence Accession: NG_064783.1
Protein Accession: WP_136512106.1
Notes: ARO:3005496

138

Gene Information

Gene Name: blaVIM
Allele: blaVIM-49
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_050376.1
Protein Accession: WP_063865198.1
Notes: ARO:3005497

139

Gene Information

Gene Name: blaVIM
Allele: blaVIM-50
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_050378.1
Protein Accession: WP_063865199.1
Notes: ARO:3005498

140

Gene Information

Gene Name: blaVIM
Allele: blaVIM-51
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: NG_050379.1
Protein Accession: WP_063865200.1
Notes: ARO:3005499

141

Gene Information

Gene Name: blaVIM
Allele: blaVIM-52
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: NG_055489.1
Protein Accession: WP_094009807.1
Notes: ARO:3005500

142

Gene Information

Gene Name: blaVIM
Allele: blaVIM-53
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_062231.1
Protein Accession: WP_122630828.1
Notes: ARO:3005501

143

Gene Information

Gene Name: blaVIM
Allele: blaVIM-54
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Serratia marcescens
Sequence Accession: NG_052864.1
Protein Accession: WP_077064888.1
Notes: ARO:3005502

144

Gene Information

Gene Name: blaVIM
Allele: blaVIM-55
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: NG_064784.1
Protein Accession: WP_136512107.1
Notes: ARO:3005503

145

Gene Information

Gene Name: blaVIM
Allele: blaVIM-56
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Citrobacter freundii
Sequence Accession: NG_056405.1
Protein Accession: WP_104009846.1
Notes: ARO:3005504

146

Gene Information

Gene Name: blaVIM
Allele: blaVIM-57
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Escherichia coli
Sequence Accession: NG_060572.1
Protein Accession: WP_111672914.1
Notes: ARO:3005505

147

Gene Information

Gene Name: blaVIM
Allele: blaVIM-58
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: NG_060588.1
Protein Accession: WP_111772163.1
Notes: ARO:3005506

148

Gene Information

Gene Name: blaVIM
Allele: blaVIM-59
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Citrobacter freundii
Sequence Accession: NG_061412.1
Protein Accession: WP_114699283.1
Notes: ARO:3005507

149

Gene Information

Gene Name: blaVIM
Allele: blaVIM-60
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_061404.1
Protein Accession: WP_114699277.1
Notes: ARO:3005508

150

Gene Information

Gene Name: blaVIM
Allele: blaVIM-61
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_062359.1
Protein Accession: WP_123002103.1
Notes: ARO:3005509

151

Gene Information

Gene Name: blaVIM
Allele: blaVIM-62
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas putida
Sequence Accession: NG_063896.1
Protein Accession: WP_128268287.1
Notes: ARO:3005510

152

Gene Information

Gene Name: blaVIM
Allele: blaVIM-63
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_064785.1
Protein Accession: WP_136512108.1
Notes: ARO:3005511

153

Gene Information

Gene Name: blaVIM
Allele: blaVIM-64
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: NG_065447.1
Protein Accession: WP_140423327.1
Notes: ARO:3005512

154

Gene Information

Gene Name: blaVIM
Allele: blaVIM-65
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Citrobacter freundii
Sequence Accession: NG_065448.1
Protein Accession: WP_140423328.1
Notes: ARO:3005513

155

Gene Information

Gene Name: blaVIM
Allele: blaVIM-66
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_064786.1
Protein Accession: WP_136512109.1
Notes: ARO:3005514

156

Gene Information

Gene Name: blaVIM
Allele: blaVIM-67
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Enterobacter hormaechei
Sequence Accession: NG_065942.1
Protein Accession: WP_142875125.1
Notes: ARO:3005515

157

Gene Information

Gene Name: blaVIM
Allele: blaVIM-68
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Providencia stuartii
Sequence Accession: NG_065943.1
Protein Accession: WP_148044476.1
Notes: ARO:3005516

158

Gene Information

Gene Name: blaVIM
Allele: blaVIM-69
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_067166.1
Protein Accession: WP_130202201.1
Notes: ARO:3005517

159

Gene Information

Gene Name: blaVIM
Allele: blaVIM-70
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_068039.1
Protein Accession: WP_164461303.1
Notes: ARO:3005518

160

Gene Information

Gene Name: blaVIM
Allele: blaVIM-71
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Vibrio alginolyticus
Sequence Accession: NG_070223.1
Protein Accession: WP_179284394.1
Notes: ARO:3005519

161

Gene Information

Gene Name: blaVIM
Allele: blaVIM-72
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_070756.1
Protein Accession: WP_188331881.1
Notes: ARO:3005520

162

Gene Information

Gene Name: blaVIM
Allele: blaVIM-73
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_070757.1
Protein Accession: WP_188331882.1
Notes: ARO:3005521

163

Gene Information

Gene Name: blaVIM
Allele: blaVIM-77
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas shirazica
Sequence Accession: NG_078035.1
Protein Accession: WP_231869637.1
Notes: ARO:3007814

164

Gene Information

Gene Name: blaVIM
Allele: blaVIM-82
Encodes: VIM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: NG_088450.1
Protein Accession: WP_238839790.1
Notes: ARO:3007819

165

Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: subclass B1 metallo-beta-lactamase VIM-1
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: Y18050.2
Protein Accession: CAB46686.1
Notes: Subclass B1

166

Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: subclass B1 metallo-beta-lactamase VIM-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: Y18050.2
Protein Accession: CAB46686.1
Notes: Subclass B1

167

Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: subclass B1 metallo-beta-lactamase VIM-1
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: Y18050.2
Protein Accession: CAB46686.1
Notes: Subclass B1

168

Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: Y18050
Notes: Subclass B1

169

Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France.

The study characterizes VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase, and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: carbapenem-hydrolyzing metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Escherichia coli
Geographic Location: France
Validation Method: cloning in E. coli DH10B and expression, MIC testing
Sequence Accession: AF191564

170

Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: subclass B1 metallo-beta-lactamase VIM-2
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF191564.1
Protein Accession: AAF61483.1
Notes: Subclass B1

171

Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: subclass B1 metallo-beta-lactamase VIM-2
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF191564.1
Protein Accession: AAF61483.1
Notes: Subclass B1

172

Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: subclass B1 metallo-beta-lactamase VIM-2
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF191564.1
Protein Accession: AAF61483.1
Notes: Subclass B1

173

Carbapenem-resistant Pseudomonas aeruginosa with acquired bla(vim) metallo-beta-lactamase determinants, Italy.

PMID 10939846 · 2000

The study identifies the acquisition of the blaVIM metallo-beta-lactamase gene in carbapenem-resistant Pseudomonas aeruginosa isolates from Italy, highlighting its role in resistance to multiple antibiotics.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenemsceftazidimecefepimeticarcillinticarcillin clavulanic acidpiperacillinpiperacillin tazobactam
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Italy
Validation Method: colony-blot hybridization assay

174

Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla(VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes.

PMID 11158753 · 2001

The study identifies two novel aminoglycoside resistance gene cassettes, aacA29a and aacA29b, which confer resistance to several aminoglycosides. Additionally, the bla(VIM-2) gene, which encodes a carbapenem-hydrolyzing beta-lactamase, was characterized in Pseudomonas aeruginosa isolates.

Gene Information

Gene Name: blaVIM
Allele: bla(VIM-2)
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: France
Validation Method: cloning in E. coli + disk diffusion
Sequence Accession: AF263519|AF263520

175

Molecular heterogeneity of bla(VIM-2)-containing integrons from Pseudomonas aeruginosa plasmids encoding the VIM-2 metallo-beta-lactamase.

PMID 11179643 · 2001

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF302086
Notes: Subclass B1

176

In70 of plasmid pAX22, a bla(VIM-1)-containing integron carrying a new aminoglycoside phosphotransferase gene cassette.

PMID 11257042 · 2001

The study identifies a new integron, In70, carrying the bla(VIM-1) gene, which confers resistance to beta-lactams, including carbapenems, and three aminoglycoside resistance genes: aacA4, aphA15, and aadA1.

Gene Information

Gene Name: blaVIM
Allele: bla(VIM-1)
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of beta-lactam antibiotics
Confers Resistance To: carbapenems
Organisms Tested In: • Achromobacter xylosoxydans
• Escherichia coli
Geographic Location: Italy
Validation Method: expression in E. coli and MIC testing
Sequence Accession: AJ278514|AJ278515

177

Metallo-beta-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme.

The study identifies VIM-3, a novel variant of the VIM-2 metallo-beta-lactamase, in clinical Pseudomonas isolates in Taiwan, highlighting the prevalence of VIM-2-related enzymes among these isolates.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Pseudomonas putida
• Pseudomonas stutzeri
Geographic Location: Taiwan
Validation Method: PCR and sequencing
Sequence Accession: AF300454

178

Metallo-beta-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme.

The study identifies VIM-3, a novel variant of the VIM-2 metallo-beta-lactamase, in clinical Pseudomonas isolates in Taiwan, highlighting the prevalence of VIM-2-related enzymes among these isolates.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-3
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Taiwan
Validation Method: PCR and sequencing
Sequence Accession: AF300454

179

Metallo-beta-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-3
Encodes: subclass B1 metallo-beta-lactamase VIM-3
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF300454.1
Protein Accession: AAG27703.1
Notes: Subclass B1

180

Metallo-beta-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-3
Encodes: subclass B1 metallo-beta-lactamase VIM-3
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF300454.1
Protein Accession: AAG27703.1
Notes: Subclass B1

181

Metallo-beta-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-3
Encodes: subclass B1 metallo-beta-lactamase VIM-3, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF300454.1
Protein Accession: AAG27703.1
Notes: Subclass B1, ARO:3002273

182

Metallo-beta-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-3
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AF300454
Notes: Subclass B1

183

Multidrug-resistant Pseudomonas aeruginosa producing PER-1 extended-spectrum serine-beta-lactamase and VIM-2 metallo-beta-lactamase.

PMID 11747713 · 2001

The study identifies the presence of blaPER-1 and blaVIM-2 genes in a multidrug-resistant Pseudomonas aeruginosa isolate, which confer resistance to multiple beta-lactam antibiotics.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenemceftazidimecefepimeaztreonampiperacillin
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Europe
Validation Method: PCR and sequencing

184

bla(VIM-2) cassette-containing novel integrons in metallo-beta-lactamase-producing Pseudomonas aeruginosa and Pseudomonas putida isolates disseminated in a Korean hospital.

PMID 11897589 · 2002

The study identifies bla(VIM-2) as a novel metallo-beta-lactamase gene responsible for carbapenem resistance in Pseudomonas aeruginosa and Pseudomonas putida isolates in a Korean hospital.

Gene Information

Gene Name: blaVIM
Allele: bla(VIM-2)
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Pseudomonas putida
Geographic Location: Korea
Validation Method: sequencing and enzymatic assays
Sequence Accession: AY029772|AF327064

185

Occurrence of a multidrug-resistant Pseudomonas aeruginosa clone in different hospitals in Rio de Janeiro, Brazil.

PMID 12089256 · 2002

The study identifies the presence of metallo-beta-lactamase (blaIMP and blaVIM) producing Pseudomonas aeruginosa isolates in Brazil, highlighting the emergence of multidrug-resistant clones in hospitals in Rio de Janeiro.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: ceftazidimecefepime
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Brazil
Validation Method: disk approximation test with disks containing CAZ and 2-mercaptopropionic acid

186

Evaluation of a new Etest for detecting metallo-beta-lactamases in routine clinical testing.

PMID 12149325 · 2002

The study evaluates a new Etest for detecting metallo-beta-lactamases, identifying blaIMP-1 and blaVIM genes as responsible for carbapenem resistance in various bacterial species.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Acinetobacter spp.
Validation Method: PCR analysis and enzyme assays

187

Novel variant (bla(VIM-4)) of the metallo-beta-lactamase gene bla(VIM-1) in a clinical strain of Pseudomonas aeruginosa.

The study identifies a novel variant of the metallo-beta-lactamase gene bla(VIM-1), termed bla(VIM-4), in a carbapenem-resistant Pseudomonas aeruginosa strain. This variant differs by a single nucleotide from bla(VIM-1), leading to a Ser-to-Arg change at amino acid position 175 of the VIM-1 enzyme.

Gene Information

Gene Name: blaVIM
Allele: bla(VIM-4)
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Greece
Validation Method: PCR and nucleotide sequencing
Sequence Accession: AY135661

188

Novel variant (bla(VIM-4)) of the metallo-beta-lactamase gene bla(VIM-1) in a clinical strain of Pseudomonas aeruginosa.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: subclass B1 metallo-beta-lactamase VIM-4
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY135661.1
Protein Accession: AAN04257.1
Notes: Subclass B1

189

Novel variant (bla(VIM-4)) of the metallo-beta-lactamase gene bla(VIM-1) in a clinical strain of Pseudomonas aeruginosa.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: subclass B1 metallo-beta-lactamase VIM-4
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY135661.1
Protein Accession: AAN04257.1
Notes: Subclass B1

190

Novel variant (bla(VIM-4)) of the metallo-beta-lactamase gene bla(VIM-1) in a clinical strain of Pseudomonas aeruginosa.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: subclass B1 metallo-beta-lactamase VIM-4
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY135661.1
Protein Accession: AAN04257.1
Notes: Subclass B1

191

VIM- and IMP-type metallo-beta-lactamase-producing Pseudomonas spp. and Acinetobacter spp. in Korean hospitals.

PMID 12890331 · 2003

The study identified bla VIM-2 and bla IMP-1 alleles as the primary metallo-beta-lactamase genes responsible for carbapenem resistance in Pseudomonas and Acinetobacter isolates in Korean hospitals.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Acinetobacter spp.
Geographic Location: Korea
Validation Method: PCR and sequencing

192

Carbapenem-resistant Pseudomonas aeruginosa-carrying VIM-2 metallo-beta-lactamase determinants, Croatia.

PMID 12971373 · 2003

The study identifies the first clinical isolates of Pseudomonas aeruginosa in Croatia carrying the blaVIM-2 gene, which confers resistance to carbapenems.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Croatia
Validation Method: PCR amplification and direct sequencing of the variable region of class 1 integrons
Sequence Accession: AY144612|AY165025

193

Evaluation of the Hodge test and the imipenem-EDTA double-disk synergy test for differentiating metallo-beta-lactamase-producing isolates of Pseudomonas spp. and Acinetobacter spp.

PMID 14532193 · 2003

The study evaluated the Hodge test and imipenem-EDTA double-disk synergy test for detecting metallo-beta-lactamase (MBL)-producing isolates of Pseudomonas and Acinetobacter. It identified blaIMP-1 and blaVIM-2 as the MBL genes responsible for carbapenem resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolyzes carbapenems
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Acinetobacter spp.
Geographic Location: Korea
Validation Method: PCR amplification

194

blaVIM-7, an evolutionarily distinct metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United States.

The study identifies blaVIM-7, a novel metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United States, which confers resistance to multiple beta-lactam antibiotics.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-7
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenemscephalosporinspenicillin
Organisms Tested In: • Pseudomonas aeruginosa
• Escherichia coli
Geographic Location: United States
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AJ536835

195

blaVIM-7, an evolutionarily distinct metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United States.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-7
Encodes: subclass B1 metallo-beta-lactamase VIM-7
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AJ536835.1
Protein Accession: CAD61201.1
Notes: Subclass B1

196

blaVIM-7, an evolutionarily distinct metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United States.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-7
Encodes: subclass B1 metallo-beta-lactamase VIM-7
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AJ536835.1
Protein Accession: CAD61201.1
Notes: Subclass B1

197

blaVIM-7, an evolutionarily distinct metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United States.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-7
Encodes: subclass B1 metallo-beta-lactamase VIM-7, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AJ536835.1
Protein Accession: CAD61201.1
Notes: Subclass B1, ARO:3002277

198

blaVIM-7, an evolutionarily distinct metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United States.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-7
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AJ536835
Notes: Subclass B1

199

Class 1 integron containing metallo-beta-lactamase gene blaVIM-2 in Pseudomonas aeruginosa clinical strains isolated in Japan.

PMID 14742222 · 2004

The study identifies the blaVIM-2 gene in Pseudomonas aeruginosa clinical strains in Japan, highlighting its presence in a class 1 integron and suggesting horizontal spread among strains.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Japan
Validation Method: PCR and sequencing
Sequence Accession: AY242981|AY242982|AY242983|AY242984|AY294333

200

IMP-1 and a novel metallo-beta-lactamase, VIM-6, in fluorescent pseudomonads isolated in Singapore.

The study identifies blaIMP-1 and a novel metallo-beta-lactamase, VIM-6, in carbapenem-resistant Pseudomonas spp. isolates from Singapore. Both genes confer resistance to various beta-lactam antibiotics.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-6
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenemaztreonamceftazidimecefepimepiperacillin tazobactam
Organisms Tested In: • Pseudomonas putida
Geographic Location: Singapore
Validation Method: sequencing and MIC testing
Sequence Accession: AY165025|AY251052|AY250709

201

IMP-1 and a novel metallo-beta-lactamase, VIM-6, in fluorescent pseudomonads isolated in Singapore.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-6
Encodes: subclass B1 metallo-beta-lactamase VIM-6
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas putida
Sequence Accession: AY165025.1
Protein Accession: AAN84550.1
Notes: Subclass B1

202

IMP-1 and a novel metallo-beta-lactamase, VIM-6, in fluorescent pseudomonads isolated in Singapore.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-6
Encodes: subclass B1 metallo-beta-lactamase VIM-6
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas putida
Sequence Accession: AY165025.1
Protein Accession: AAN84550.1
Notes: Subclass B1

203

IMP-1 and a novel metallo-beta-lactamase, VIM-6, in fluorescent pseudomonads isolated in Singapore.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-6
Encodes: subclass B1 metallo-beta-lactamase VIM-6, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas putida
Sequence Accession: AY165025.1
Protein Accession: AAN84550.1
Notes: Subclass B1, ARO:3002276

204

IMP-1 and a novel metallo-beta-lactamase, VIM-6, in fluorescent pseudomonads isolated in Singapore.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-6
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas putida
Sequence Accession: AY165025
Notes: Subclass B1

205

Detection of VIM-5 metallo-beta-lactamase in a Pseudomonas aeruginosa clinical isolate from Turkey.

PMID 15190017 · 2004

Gene Information

Gene Name: blaVIM
Allele: blaVIM-5
Encodes: subclass B1 metallo-beta-lactamase VIM-5
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AY144612.1
Protein Accession: AAN52134.1
Notes: Subclass B1

206

Detection of VIM-5 metallo-beta-lactamase in a Pseudomonas aeruginosa clinical isolate from Turkey.

PMID 15190017 · 2004

Gene Information

Gene Name: blaVIM
Allele: blaVIM-5
Encodes: subclass B1 metallo-beta-lactamase VIM-5
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AY144612.1
Protein Accession: AAN52134.1
Notes: Subclass B1

207

Detection of VIM-5 metallo-beta-lactamase in a Pseudomonas aeruginosa clinical isolate from Turkey.

PMID 15190017 · 2004

Gene Information

Gene Name: blaVIM
Allele: blaVIM-5
Encodes: subclass B1 metallo-beta-lactamase VIM-5, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AY144612.1
Protein Accession: AAN52134.1
Notes: Subclass B1, ARO:3002275

208

Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-8, a novel metallo-beta-lactamase, in a tertiary care center in Cali, Colombia.

The study identifies VIM-8, a novel metallo-beta-lactamase, as the resistance mechanism in a carbapenem-resistant Pseudomonas aeruginosa outbreak in Colombia.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-8
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Colombia
Validation Method: sequencing of DNA from a representative isolate
Sequence Accession: AY524987

209

Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-8, a novel metallo-beta-lactamase, in a tertiary care center in Cali, Colombia.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-8
Encodes: subclass B1 metallo-beta-lactamase VIM-8
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY524987.1
Protein Accession: AAS13759.1
Notes: Subclass B1

210

Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-8, a novel metallo-beta-lactamase, in a tertiary care center in Cali, Colombia.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-8
Encodes: subclass B1 metallo-beta-lactamase VIM-8
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY524987.1
Protein Accession: AAS13759.1
Notes: Subclass B1

211

Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-8, a novel metallo-beta-lactamase, in a tertiary care center in Cali, Colombia.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-8
Encodes: subclass B1 metallo-beta-lactamase VIM-8, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY524987.1
Protein Accession: AAS13759.1
Notes: Subclass B1, ARO:3002278

212

Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-8, a novel metallo-beta-lactamase, in a tertiary care center in Cali, Colombia.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-8
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY524987
Notes: Subclass B1

213

Metallo-beta-lactamase-Producing Gram-Negative Bacilli: Laboratory-Based Surveillance in Cooperation with 13 Clinical Laboratories in the Kinki Region of Japan.

PMID 15528723 · 2004

The study identified metallo-beta-lactamase (MBL) genes, including blaIMP-1, blaIMP-2, and blaVIM-2, in various gram-negative bacilli, highlighting the widespread distribution of MBL-producing organisms in the Kinki region of Japan.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenemspenicillin
Organisms Tested In: • Pseudomonas aeruginosa
• Enterobacter cloacae
Geographic Location: Japan
Validation Method: PCR and DNA sequencing

214

Clonal Relatedness and Conserved Integron Structures in Epidemiologically Unrelated Pseudomonas aeruginosa Strains Producing the VIM-1 Metallo-β-lactamase from Different Italian Hospitals.

PMID 15616282 · 2005

The study identifies the VIM-1 metallo-beta-lactamase as a key resistance factor in Pseudomonas aeruginosa isolates from Italian hospitals, highlighting the conserved integron structures and clonal relatedness among the isolates.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Italy
Validation Method: sequencing and hybridization assays
Sequence Accession: Y18050|AJ581664|AJ581665

215

Novel variant (bla(VIM-11)) of the metallo-{beta}-lactamase bla(VIM) family in a GES-1 extended-spectrum-{beta}-lactamase-producing Pseudomonas aeruginosa clinical isolate in Argentina.

The study reports the identification of a novel variant of the metallo-beta-lactamase bla(VIM) family, designated bla(VIM-11), in a GES-1 extended-spectrum-beta-lactamase-producing Pseudomonas aeruginosa clinical isolate in Argentina.

Gene Information

Gene Name: blaVIM
Allele: bla(VIM-11)
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Argentina
Validation Method: DNA sequencing and MIC testing
Sequence Accession: AY605049

216

Novel variant (bla(VIM-11)) of the metallo-{beta}-lactamase bla(VIM) family in a GES-1 extended-spectrum-{beta}-lactamase-producing Pseudomonas aeruginosa clinical isolate in Argentina.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-11
Encodes: subclass B1 metallo-beta-lactamase VIM-11
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY605049.2
Protein Accession: AAT36613.1
Notes: Subclass B1

217

Novel variant (bla(VIM-11)) of the metallo-{beta}-lactamase bla(VIM) family in a GES-1 extended-spectrum-{beta}-lactamase-producing Pseudomonas aeruginosa clinical isolate in Argentina.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-11
Encodes: subclass B1 metallo-beta-lactamase VIM-11
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY605049.2
Protein Accession: AAT36613.1
Notes: Subclass B1

218

Novel variant (bla(VIM-11)) of the metallo-{beta}-lactamase bla(VIM) family in a GES-1 extended-spectrum-{beta}-lactamase-producing Pseudomonas aeruginosa clinical isolate in Argentina.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-11
Encodes: subclass B1 metallo-beta-lactamase VIM-11, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY605049.2
Protein Accession: AAT36613.1
Notes: Subclass B1, ARO:3002281

219

Novel variant (bla(VIM-11)) of the metallo-{beta}-lactamase bla(VIM) family in a GES-1 extended-spectrum-{beta}-lactamase-producing Pseudomonas aeruginosa clinical isolate in Argentina.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-11
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY605049
Notes: Subclass B1

220

Metallo-beta-lactamases: the quiet before the storm?

The paper characterizes various metallo-beta-lactamase genes (blaIMP and blaVIM) and their roles in conferring resistance to carbapenems in multiple bacterial species.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Achromobacter xylosoxidans
• Escherichia coli
• Klebsiella pneumoniae
Geographic Location: Japan|Italy|Portugal|South Korea|Taiwan|France|Greece|USA|Turkey|Singapore|Brazil|Argentina|South America|Southern Europe|Southeast Asia
Validation Method: cloning and MIC testing
Sequence Accession: AY033653|AB074437|AB074436|AJ584652|AY524987.1|AY534988.1|AY524989.1|AY605049.1|AY635904.1|AY534988|AY534989|AY605049|AY635904

221

Metallo-beta-lactamases: the quiet before the storm?

The paper characterizes various metallo-beta-lactamase genes (blaIMP and blaVIM) and their roles in conferring resistance to carbapenems in multiple bacterial species.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Enterobacter cloacae
• Citrobacter freundii
• Serratia marcescens
Geographic Location: Japan|Italy|Portugal|South Korea|Taiwan|France|Greece|USA|Turkey|Singapore|Brazil|Argentina|South America|Southern Europe|Southeast Asia
Validation Method: cloning and MIC testing
Sequence Accession: AY033653|AB074437|AB074436|AJ584652|AY524987.1|AY534988.1|AY524989.1|AY605049.1|AY635904.1|AY534988|AY534989|AY605049|AY635904

222

Metallo-beta-lactamases: the quiet before the storm?

The paper characterizes various metallo-beta-lactamase genes (blaIMP and blaVIM) and their roles in conferring resistance to carbapenems in multiple bacterial species.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-3
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Japan|Italy|Portugal|South Korea|Taiwan|France|Greece|USA|Turkey|Singapore|Brazil|Argentina|South America|Southern Europe|Southeast Asia
Validation Method: cloning and MIC testing
Sequence Accession: AY033653|AB074437|AB074436|AJ584652|AY524987.1|AY534988.1|AY524989.1|AY605049.1|AY635904.1|AY534988|AY534989|AY605049|AY635904

223

Metallo-beta-lactamases: the quiet before the storm?

The paper characterizes various metallo-beta-lactamase genes (blaIMP and blaVIM) and their roles in conferring resistance to carbapenems in multiple bacterial species.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Klebsiella pneumoniae
• Enterobacter cloacae
Geographic Location: Japan|Italy|Portugal|South Korea|Taiwan|France|Greece|USA|Turkey|Singapore|Brazil|Argentina|South America|Southern Europe|Southeast Asia
Validation Method: cloning and MIC testing
Sequence Accession: AY033653|AB074437|AB074436|AJ584652|AY524987.1|AY534988.1|AY524989.1|AY605049.1|AY635904.1|AY534988|AY534989|AY605049|AY635904

224

Metallo-beta-lactamases: the quiet before the storm?

The paper characterizes various metallo-beta-lactamase genes (blaIMP and blaVIM) and their roles in conferring resistance to carbapenems in multiple bacterial species.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-5
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
• Pseudomonas aeruginosa
Geographic Location: Japan|Italy|Portugal|South Korea|Taiwan|France|Greece|USA|Turkey|Singapore|Brazil|Argentina|South America|Southern Europe|Southeast Asia
Validation Method: cloning and MIC testing
Sequence Accession: AY033653|AB074437|AB074436|AJ584652|AY524987.1|AY534988.1|AY524989.1|AY605049.1|AY635904.1|AY534988|AY534989|AY605049|AY635904

225

Metallo-beta-lactamases: the quiet before the storm?

The paper characterizes various metallo-beta-lactamase genes (blaIMP and blaVIM) and their roles in conferring resistance to carbapenems in multiple bacterial species.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-6
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas putida
Geographic Location: Japan|Italy|Portugal|South Korea|Taiwan|France|Greece|USA|Turkey|Singapore|Brazil|Argentina|South America|Southern Europe|Southeast Asia
Validation Method: cloning and MIC testing
Sequence Accession: AY033653|AB074437|AB074436|AJ584652|AY524987.1|AY534988.1|AY524989.1|AY605049.1|AY635904.1|AY534988|AY534989|AY605049|AY635904

226

Detection of Pseudomonas aeruginosa producing metallo-beta-lactamases in a large centralized laboratory.

PMID 16000424 · 2005

The study identifies bla VIM and bla IMP genes as the primary metallo-beta-lactamase genes responsible for carbapenem resistance in Pseudomonas aeruginosa isolates.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Canada
Validation Method: duplex PCR and phenotypic testing

227

First nosocomial outbreak of Pseudomonas aeruginosa producing an integron-borne metallo-beta-lactamase (VIM-2) in the United States.

PMID 16048978 · 2005

The study reports the first nosocomial outbreak of Pseudomonas aeruginosa producing the metallo-beta-lactamase VIM-2 in the United States, highlighting the emergence of carbapenemases on mobile genetic elements.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolyzes carbapenems and other beta-lactams
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: United States
Validation Method: PCR and sequencing
Sequence Accession: AY943084

228

Genetic and enzymatic properties of metallo-beta-lactamase VIM-5 from a clinical isolate of Enterobacter cloacae.

PMID 16189133 · 2005

The study characterizes the metallo-beta-lactamase VIM-5 from a clinical isolate of Enterobacter cloacae, demonstrating its ability to hydrolyze carbapenems and confer resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-5
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacter cloacae
• Escherichia coli
Geographic Location: Turkey
Validation Method: purification and enzymatic activity testing
Sequence Accession: AY910754|DQ023222

229

Genetic and enzymatic properties of metallo-beta-lactamase VIM-5 from a clinical isolate of Enterobacter cloacae.

PMID 16189133 · 2005

Gene Information

Gene Name: blaVIM
Allele: blaVIM-5
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: DQ023222
Notes: Subclass B1

230

Sensitive EDTA-Based Microbiological Assays for Detection of Metallo-β-Lactamases in Nonfermentative Gram-Negative Bacteria.

PMID 16272499 · 2005

The study describes the development of a sensitive microbiological assay (EIM) for detecting metallo-β-lactamases (MBLs) in nonfermentative gram-negative bacteria. It identifies several MBL genes, including bla VIM-11a, bla IMP-7, bla SPM-1, bla L1-like, bla GOB-like, bla IND-like, and bla BcII, which confer resistance to carbapenems.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-11a
Encodes: metallobeta-lactamase
Source Database: Reslit
Mechanism: hydrolyzes carbapenems
Confers Resistance To: imipenemmeropenem
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Argentina
Validation Method: spectrophotometric assay and PCR

231

VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid.

The study identifies blaVIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae, which shows characteristics of both VIM-1 and VIM-2.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-12
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of beta-lactam ring
Confers Resistance To: carbapenemscephalosporinspenicillin
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
Geographic Location: Greece
Validation Method: cloning in E. coli + agar dilution MICs
Sequence Accession: DQ143913

232

VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-12
Encodes: subclass B1 metallo-beta-lactamase VIM-12
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: DQ143913.1
Protein Accession: AAZ73123.1
Notes: Subclass B1

233

VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-12
Encodes: subclass B1 metallo-beta-lactamase VIM-12
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: DQ143913.1
Protein Accession: AAZ73123.1
Notes: Subclass B1

234

VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-12
Encodes: subclass B1 metallo-beta-lactamase VIM-12, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: DQ143913.1
Protein Accession: AAZ73123.1
Notes: Subclass B1, ARO:3002282

235

VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-12
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: DQ143913
Notes: Subclass B1

236

First detection of metallo-beta-lactamase VIM-2 in Pseudomonas aeruginosa isolates from Colombia.

PMID 16377690 · 2006

The study reports the first detection of the metallo-beta-lactamase VIM-2 in Pseudomonas aeruginosa isolates from Colombia, highlighting its role in carbapenem resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Colombia
Validation Method: PCR and sequencing
Sequence Accession: AY568115

237

Molecular Epidemiology of Acquired-Metallo-β-Lactamase-Producing Bacteria in Poland

PMID 16495246 · 2006

The study identified bla VIM-2 and bla VIM-4 genes as the primary mechanisms of carbapenem resistance in metallo-β-lactamase-producing bacteria in Poland, highlighting their widespread distribution and association with class 1 integrons.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: penicillincephalosporinscarbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Acinetobacter genospecies 3
• Pseudomonas putida
Geographic Location: Poland
Validation Method: PCR, sequencing, and antimicrobial susceptibility testing
Sequence Accession: AM087404|AM087405|AM087406|AM087407|AM087408|AM087409|AM087410|AM087411

238

Molecular Epidemiology of Acquired-Metallo-β-Lactamase-Producing Bacteria in Poland

PMID 16495246 · 2006

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: penicillincephalosporinscarbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Poland
Validation Method: PCR, sequencing, and antimicrobial susceptibility testing
Sequence Accession: AM087404|AM087405|AM087406|AM087407|AM087408|AM087409|AM087410|AM087411

239

VIM-1 metallo-beta-lactamase in Acinetobacter baumannii.

PMID 16707056 · 2006

The study reports the first identification of the VIM-1 metallo-beta-lactamase in Acinetobacter baumannii, highlighting its role in carbapenem resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Greece
Validation Method: PCR and sequencing
Sequence Accession: DQ112355

240

Molecular Evolution of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in a Nosocomial Setting of High-Level Endemicity.

PMID 16825348 · 2006

The study characterizes the molecular evolution of metallo-beta-lactamase-producing Pseudomonas aeruginosa strains, identifying bla VIM-1 and bla VIM-2 as the primary resistance genes responsible for carbapenem resistance in the hospital setting.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Italy
Validation Method: dot blot hybridization and PCR-RFLP analysis
Sequence Accession: AM180753|DQ353808

241

Molecular Evolution of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in a Nosocomial Setting of High-Level Endemicity.

PMID 16825348 · 2006

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Italy
Validation Method: dot blot hybridization and PCR-RFLP analysis
Sequence Accession: AM180753|DQ353808

242

Phenotypic detection of carbapenem-susceptible metallo-beta-lactamase-producing gram-negative bacilli in the clinical laboratory.

PMID 16954239 · 2006

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas sp.
Validation Method: PCR and phenotypic testing

243

Phenotypic detection of carbapenem-susceptible metallo-beta-lactamase-producing gram-negative bacilli in the clinical laboratory.

PMID 16954239 · 2006

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas sp.
Validation Method: PCR and phenotypic testing

244

Establishing clonal relationships between VIM-1-like metallo-beta-lactamase-producing Pseudomonas aeruginosa strains from four European countries by multilocus sequence typing.

PMID 17021059 · 2006

The study identifies and characterizes VIM-1, VIM-2, and VIM-4 metallo-beta-lactamase genes in Pseudomonas aeruginosa strains from four European countries, highlighting their role in multidrug resistance and clonal relationships.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenemscephalosporinspiperacillin tazobactamaztreonam
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Europe|Greece|Hungary|Italy|Sweden
Validation Method: PCR and sequencing
Sequence Accession: DQ465011|AJ865694|AJ865693|AJ634050|AJ786649|AY702100|AY866525|AY460181

245

Establishing clonal relationships between VIM-1-like metallo-beta-lactamase-producing Pseudomonas aeruginosa strains from four European countries by multilocus sequence typing.

PMID 17021059 · 2006

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Europe|Greece|Hungary|Italy|Sweden
Validation Method: PCR and sequencing
Sequence Accession: DQ465011|AJ865694|AJ865693|AJ634050|AJ786649|AY702100|AY866525|AY460181

246

Establishing clonal relationships between VIM-1-like metallo-beta-lactamase-producing Pseudomonas aeruginosa strains from four European countries by multilocus sequence typing.

PMID 17021059 · 2006

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenemscephalosporinspiperacillin tazobactamaztreonam
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Europe|Greece|Hungary|Italy|Sweden
Validation Method: PCR and sequencing
Sequence Accession: DQ465011|AJ865694|AJ865693|AJ634050|AJ786649|AY702100|AY866525|AY460181

247

Molecular Epidemiology of Metallo-beta-lactamase-Producing Pseudomonas aeruginosa in the Calgary Health Region: Emergence of VIM-2-Producing Isolates.

PMID 17122002 · 2007

The study identifies VIM-2 and IMP-7 metallo-beta-lactamase genes along with aacC1, aacA4, and aacC4 gene cassettes in Pseudomonas aeruginosa isolates, highlighting the molecular epidemiology of carbapenem-resistant strains in the Calgary Health Region.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of β-lactam antibiotics
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Calgary Health Region
Validation Method: PCR and sequencing

248

VIM-2-producing Pseudomonas putida, Buenos Aires.

PMID 17561577 · 2007

The study reports the identification of VIM-2-producing Pseudomonas putida isolates in Buenos Aires, Argentina, which exhibit resistance to various beta-lactam antibiotics, including carbapenems.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenemertapenempiperacillinpiperacillin tazobactamceftazidimecefepimeaztreonam
Organisms Tested In: • Pseudomonas putida
Geographic Location: Argentina
Validation Method: PCR amplification and sequencing
Sequence Accession: NC_010655

249

Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals.

PMID 17938181 · 2007

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: carbapenemase
Source Database: Reslit
Mechanism: carbapenemase
Confers Resistance To: imipenemmeropenem
Organisms Tested In: • Pseudomonas aeruginosa
• Escherichia coli
Validation Method: PCR amplification and sequencing

250

Outbreak caused by a multidrug-resistant Klebsiella pneumoniae clone carrying blaVIM-12 in a university hospital.

PMID 18199780 · 2008

The study identifies a novel blaVIM-12 metallo-beta-lactamase gene in a multidrug-resistant Klebsiella pneumoniae clone responsible for an outbreak in a university hospital.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-12
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: Greece
Validation Method: PCR, sequencing, and transferability experiments
Sequence Accession: EU109700

251

Successive emergence of extended-spectrum beta-lactamase-producing and carbapenemase-producing Enterobacter aerogenes isolates in a university hospital.

PMID 18234876 · 2008

The study identifies bla TEM-24, bla SHV-12, bla IMP-1, and bla VIM-2 as the primary resistance genes in carbapenem-resistant Enterobacter aerogenes isolates, highlighting the role of beta-lactamases in resistance to various antibiotics.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenem
Organisms Tested In: • Enterobacter aerogenes
Validation Method: phenotypic detection and sequencing

252

Identification of the first VIM metallo-beta-lactamase-producing multiresistant Aeromonas hydrophila strain.

PMID 18367570 · 2008

The study identifies the first VIM metallo-beta-lactamase-producing Aeromonas hydrophila strain, highlighting the presence of the blaVIM-4 gene on a class 1 integron, which confers resistance to carbapenems.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Aeromonas hydrophila
Geographic Location: Hungary
Validation Method: PCR and sequencing
Sequence Accession: EU581706

253

Identification of the first VIM metallo-beta-lactamase-producing multiresistant Aeromonas hydrophila strain.

PMID 18367570 · 2008

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Aeromonas hydrophila
Sequence Accession: EU581706
Notes: Subclass B1

254

Imported PER-1 producing Pseudomonas aeruginosa, PER-1 producing Acinetobacter baumanii and VIM-2-producing Pseudomonas aeruginosa strains in Hungary.

PMID 18513394 · 2008

The study reports the first detection of PER-1-producing Pseudomonas aeruginosa and Acinetobacter baumanii strains, as well as VIM-2-producing Pseudomonas aeruginosa in Hungary. These strains exhibited resistance to multiple beta-lactam antibiotics.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenemertapenemceftazidimecefotaximecefepime
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Hungary
Validation Method: PCR and sequencing

255

VIM-15 and VIM-16, Two New VIM-2-Like Metallo-β-Lactamases in Pseudomonas aeruginosa Isolates from Bulgaria and Germany.

The study identified two new VIM-2-like metallo-beta-lactamases, VIM-15 and VIM-16, in Pseudomonas aeruginosa isolates from Bulgaria and Germany. These enzymes confer resistance to various beta-lactam antibiotics, including carbapenems, cephalosporins, and penicillins.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-15
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of beta-lactam antibiotics
Confers Resistance To: carbapenemscephalosporinspenicillin
Organisms Tested In: • Pseudomonas aeruginosa
• Escherichia coli DH5α
Geographic Location: Bulgaria|Germany
Validation Method: cloning in E. coli DH5α and MIC testing
Sequence Accession: EU419745|EU419746

256

VIM-15 and VIM-16, Two New VIM-2-Like Metallo-β-Lactamases in Pseudomonas aeruginosa Isolates from Bulgaria and Germany.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-16
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of beta-lactam antibiotics
Confers Resistance To: carbapenemscephalosporinspenicillin
Organisms Tested In: • Pseudomonas aeruginosa
• Escherichia coli DH5α
Geographic Location: Bulgaria|Germany
Validation Method: cloning in E. coli DH5α and MIC testing
Sequence Accession: EU419745|EU419746

257

VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-15
Encodes: subclass B1 metallo-beta-lactamase VIM-15
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: EU419745.1
Protein Accession: ACB54702.1
Notes: Subclass B1

258

VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-15
Encodes: subclass B1 metallo-beta-lactamase VIM-15
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: EU419745.1
Protein Accession: ACB54702.1
Notes: Subclass B1

259

VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-15
Encodes: subclass B1 metallo-beta-lactamase VIM-15, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: EU419745.1
Protein Accession: ACB54702.1
Notes: Subclass B1, ARO:3002285

260

VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-16
Encodes: subclass B1 metallo-beta-lactamase VIM-16
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: EU419746.1
Protein Accession: ACB54703.1
Notes: Subclass B1

261

VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-16
Encodes: subclass B1 metallo-beta-lactamase VIM-16
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: EU419746.1
Protein Accession: ACB54703.1
Notes: Subclass B1

262

VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-16
Encodes: subclass B1 metallo-beta-lactamase VIM-16, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: EU419746.1
Protein Accession: ACB54703.1
Notes: Subclass B1, ARO:3002286

263

VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-15
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: EU419745
Notes: Subclass B1

264

VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-16
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: EU419746
Notes: Subclass B1

265

Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain.

The study identifies and characterizes the new metallo-beta-lactamase VIM-13, which confers resistance to carbapenems and other beta-lactams in Pseudomonas aeruginosa and Escherichia coli.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-13
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Escherichia coli
Geographic Location: Spain
Validation Method: cloning in E. coli and P. aeruginosa backgrounds, MIC testing
Sequence Accession: DQ365886|EF577407|EF577408

266

Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-13
Encodes: subclass B1 metallo-beta-lactamase VIM-13
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: DQ365886.1
Protein Accession: ABC94518.1
Notes: Subclass B1

267

Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-13
Encodes: subclass B1 metallo-beta-lactamase VIM-13
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: DQ365886.1
Protein Accession: ABC94518.1
Notes: Subclass B1

268

Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-13
Encodes: subclass B1 metallo-beta-lactamase VIM-13, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: DQ365886.1
Protein Accession: ABC94518.1
Notes: Subclass B1, ARO:3002283

269

Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-13
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: DQ365886
Notes: Subclass B1

270

First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy.

PMID 18809945 · 2008

The study identified the presence of acquired metallo-beta-lactamases (MBLs) in gram-negative pathogens in Italy, including blaIMP-13, blaVIM-1, and blaVIM-2 genes. These genes conferred resistance to carbapenems, cephalosporins, fluoroquinolones, and gentamicin in Pseudomonas aeruginosa, Pseudomonas putida, and Enterobacter cloacae.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallobetalactamase
Source Database: Reslit
Confers Resistance To: carbapenemscephalosporins
Organisms Tested In: • Pseudomonas aeruginosa
• Pseudomonas putida
• Enterobacter cloacae
Geographic Location: Italy
Validation Method: molecular analysis and phenotypic testing
Sequence Accession: FJ172675|FJ172674|FJ172676

271

First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy.

PMID 18809945 · 2008

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallobetalactamase
Source Database: Reslit
Confers Resistance To: carbapenemscephalosporins
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Italy
Validation Method: molecular analysis and phenotypic testing
Sequence Accession: FJ172675|FJ172674|FJ172676

272

Detection of Pseudomonas aeruginosa isolates producing VEB-type extended-spectrum beta-lactamases in the United Kingdom.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-10
Encodes: subclass B1 metallo-beta-lactamase VIM-10
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY524989.1
Protein Accession: AAS13761.1
Notes: Subclass B1

273

Detection of Pseudomonas aeruginosa isolates producing VEB-type extended-spectrum beta-lactamases in the United Kingdom.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-10
Encodes: subclass B1 metallo-beta-lactamase VIM-10
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY524989.1
Protein Accession: AAS13761.1
Notes: Subclass B1

274

Detection of Pseudomonas aeruginosa isolates producing VEB-type extended-spectrum beta-lactamases in the United Kingdom.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-10
Encodes: subclass B1 metallo-beta-lactamase VIM-10, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY524989.1
Protein Accession: AAS13761.1
Notes: Subclass B1, ARO:3002280

275

Detection of Pseudomonas aeruginosa isolates producing VEB-type extended-spectrum beta-lactamases in the United Kingdom.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-9
Encodes: subclass B1 metallo-beta-lactamase VIM-9
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY524988.1
Protein Accession: AAS13760.1
Notes: Subclass B1

276

Detection of Pseudomonas aeruginosa isolates producing VEB-type extended-spectrum beta-lactamases in the United Kingdom.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-9
Encodes: subclass B1 metallo-beta-lactamase VIM-9
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY524988.1
Protein Accession: AAS13760.1
Notes: Subclass B1

277

Detection of Pseudomonas aeruginosa isolates producing VEB-type extended-spectrum beta-lactamases in the United Kingdom.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-9
Encodes: subclass B1 metallo-beta-lactamase VIM-9, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY524988.1
Protein Accession: AAS13760.1
Notes: Subclass B1, ARO:3002279

278

Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18).

The study identifies multiple VIM metallo-beta-lactamase variants (VIM-2, VIM-5, VIM-6, VIM-11, and VIM-18) in carbapenem-resistant Pseudomonas aeruginosa strains from India, highlighting their widespread distribution and genetic diversity.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-18
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• E. coli
Geographic Location: India
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AM778091

279

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• E. coli
Geographic Location: India
Validation Method: PCR and sequencing
Sequence Accession: AM778091

280

Gene Information

Gene Name: blaVIM
Allele: blaVIM-5
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Escherichia coli
Geographic Location: India
Validation Method: PCR and sequencing
Sequence Accession: AM778091

281

Gene Information

Gene Name: blaVIM
Allele: blaVIM-6
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: India
Validation Method: PCR and sequencing
Sequence Accession: AM778091

282

Gene Information

Gene Name: blaVIM
Allele: blaVIM-11
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Pseudomonas stutzeri
Geographic Location: India
Validation Method: PCR and sequencing
Sequence Accession: AM778091

283

Gene Information

Gene Name: blaVIM
Allele: blaVIM-18
Encodes: subclass B1 metallo-beta-lactamase VIM-18
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFEPIME-TANIBORBACTAMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AM778091.1
Protein Accession: CAO83029.1
Notes: Subclass B1

284

Gene Information

Gene Name: blaVIM
Allele: blaVIM-18
Encodes: subclass B1 metallo-beta-lactamase VIM-18
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFEPIME-TANIBORBACTAMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AM778091.1
Protein Accession: CAO83029.1
Notes: Subclass B1

285

Gene Information

Gene Name: blaVIM
Allele: blaVIM-18
Encodes: subclass B1 metallo-beta-lactamase VIM-18, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFEPIME-TANIBORBACTAMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AM778091.1
Protein Accession: CAO83029.1
Notes: Subclass B1, ARO:3002288

286

Gene Information

Gene Name: blaVIM
Allele: blaVIM-18
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AM778091
Notes: Subclass B1

287

Molecular epidemiology of outbreak-related pseudomonas aeruginosa strains carrying the novel variant blaVIM-17 metallo-beta-lactamase gene.

The study identifies blaVIM-17, a novel variant of the VIM-type metallo-beta-lactamase gene, responsible for carbapenem resistance in outbreak-related Pseudomonas aeruginosa strains.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-17
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolyzes carbapenems
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Greece
Validation Method: PCR and sequencing
Sequence Accession: EU118148|EU118149

288

Molecular epidemiology of outbreak-related pseudomonas aeruginosa strains carrying the novel variant blaVIM-17 metallo-beta-lactamase gene.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-17
Encodes: subclass B1 metallo-beta-lactamase VIM-17
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: EU118148.2
Protein Accession: ABW90721.1
Notes: Subclass B1

289

Molecular epidemiology of outbreak-related pseudomonas aeruginosa strains carrying the novel variant blaVIM-17 metallo-beta-lactamase gene.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-17
Encodes: subclass B1 metallo-beta-lactamase VIM-17
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: EU118148.2
Protein Accession: ABW90721.1
Notes: Subclass B1

290

Molecular epidemiology of outbreak-related pseudomonas aeruginosa strains carrying the novel variant blaVIM-17 metallo-beta-lactamase gene.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-17
Encodes: subclass B1 metallo-beta-lactamase VIM-17, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: EU118148.2
Protein Accession: ABW90721.1
Notes: Subclass B1, ARO:3002287

291

Molecular epidemiology of outbreak-related pseudomonas aeruginosa strains carrying the novel variant blaVIM-17 metallo-beta-lactamase gene.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-17
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: EU118148
Notes: Subclass B1

292

Evaluation of phenotypic tests for detection of metallo-beta-lactamase-producing Pseudomonas aeruginosa strains in China.

PMID 19213696 · 2009

The study identified and characterized bla VIM-2, bla IMP-9, and bla IMP-1 genes in metallo-beta-lactamase-producing Pseudomonas aeruginosa strains in China.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of beta-lactam antibiotics
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: China
Validation Method: PCR and DNA sequence analysis

293

Molecular Diagnostic Technologies in Clinical Microbiology

PMID 19377839 · 2010

The paper describes a DNA microarray for genotyping antibiotic resistance in Pseudomonas aeruginosa, identifying several resistance genes and mutations associated with various antibiotics.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: DNA microarray genotyping

294

Infections with VIM-1 Metallo-β-Lactamase-Producing Enterobacter cloacae and Their Correlation with Clinical Outcome

PMID 19741074 · 2009

The study identifies the blaVIM-1 gene as a key factor in carbapenem resistance among Enterobacter cloacae strains, highlighting its role in clinical outcomes and the challenges in detecting its presence through standard susceptibility tests.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallobetalactamase
Source Database: Reslit
Mechanism: hydrolyzes carbapenems and other β-lactam antibiotics
Confers Resistance To: imipenemmeropenemertapenem
Organisms Tested In: • Enterobacter cloacae
Geographic Location: Italy
Validation Method: molecular analysis and β-lactamase assays

295

Large dissemination of VIM-2-metallo-beta-lactamase-producing pseudomonas aeruginosa strains causing health care-associated community-onset infections.

PMID 19776233 · 2009

The study identifies the blaVIM-2 gene as a key factor in carbapenem resistance among Pseudomonas aeruginosa strains causing healthcare-associated community-onset infections.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Greece
Validation Method: PCR and sequencing

296

Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion.

PMID 19884381 · 2010

The study identifies blaVIM-2, blaVIM-4, and blaIMP-14 as metallo-beta-lactamase genes contributing to carbapenem resistance in Pseudomonas aeruginosa isolates from Norway and Sweden.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Norway|Sweden
Validation Method: sequencing and integron analysis
Sequence Accession: FN397623|FN397626|FN397624|FN397625|FN397622|FN397621|FN397620|FN397619|FN397618|FN397628|FN397627

297

Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion.

PMID 19884381 · 2010

The study identifies blaVIM-2, blaVIM-4, and blaIMP-14 as metallo-beta-lactamase genes contributing to carbapenem resistance in Pseudomonas aeruginosa isolates from Norway and Sweden.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Norway|Sweden
Validation Method: sequencing and integron analysis
Sequence Accession: FN397623|FN397626|FN397624|FN397625|FN397622|FN397621|FN397620|FN397619|FN397618|FN397628|FN397627

298

Novel VIM Metallo-beta-lactamase Variant from Clinical Isolates of Enterobacteriaceae from Algeria.

PMID 19901092 · 2010

The study reports the identification of a novel VIM-type metallo-beta-lactamase, VIM-19, in clinical isolates of Enterobacteriaceae from Algeria. VIM-19 differs from VIM-1 by two amino acid substitutions and exhibits broad-spectrum hydrolytic activity against β-lactam antibiotics.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-19
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenemspenicillincephalosporins
Organisms Tested In: • Escherichia coli
• Klebsiella pneumoniae
• Providencia stuartii
Geographic Location: Algeria
Validation Method: purification and determination of kinetic constants
Sequence Accession: FJ499397

299

Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria.

PMID 19901092 · 2010

Gene Information

Gene Name: blaVIM
Allele: blaVIM-19
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Escherichia coli
Sequence Accession: FJ499397
Notes: Subclass B1

300

Dispersal of carbapenemase blaVIM-1 gene associated with different Tn402 variants, mercury transposons, and conjugative plasmids in Enterobacteriaceae and Pseudomonas aeruginosa.

PMID 19901094 · 2010

The study characterizes the dispersal of the blaVIM-1 gene, which confers resistance to carbapenems, in various Enterobacteriaceae and Pseudomonas aeruginosa isolates, highlighting its association with different genetic platforms including Tn402 variants, mercury transposons, and conjugative plasmids.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: carbapenemase
Source Database: Reslit
Mechanism: hydrolysis of carbapenems
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacteriaceae
• Pseudomonas aeruginosa
Geographic Location: Spain
Validation Method: PCR and sequencing
Sequence Accession: GQ422826|GQ422827|GQ422828|GQ422829

301

VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae.

The study identifies VIM-19, a novel metallo-beta-lactamase with increased carbapenemase activity, resulting from two amino acid substitutions (Asn215Lys and Ser228Arg) compared to VIM-1.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-19
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Escherichia coli
• Klebsiella pneumoniae
Geographic Location: Algeria
Validation Method: expression in E. coli TOP10 and MIC determination
Sequence Accession: FJ822963

302

VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-19
Encodes: subclass B1 metallo-beta-lactamase VIM-19
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Escherichia coli
Sequence Accession: FJ822963.1
Protein Accession: ACY29468.1
Notes: Subclass B1

303

VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-19
Encodes: subclass B1 metallo-beta-lactamase VIM-19
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Escherichia coli
Sequence Accession: FJ822963.1
Protein Accession: ACY29468.1
Notes: Subclass B1

304

VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-19
Encodes: subclass B1 metallo-beta-lactamase VIM-19, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Escherichia coli
Sequence Accession: FJ822963.1
Protein Accession: ACY29468.1
Notes: Subclass B1, ARO:3002289

305

Updated functional classification of beta-lactamases.

PMID 19995920 · 2010

The paper updates the functional classification of beta-lactamases, detailing their substrate preferences, inhibitor profiles, and clinical relevance. It highlights the diversity and evolution of these enzymes, emphasizing their role in antibiotic resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: functional characterization

306

Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding.

PMID 20498317 · 2010

The study identifies Trp-87 as an essential determinant for the stability and folding of VIM-2 metallo-beta-lactamase, which is crucial for its resistance function against various β-lactam antibiotics.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: Mutations at positions 61, 64, 67, and 87 were analyzed for their effect on ampicillin resistance.
Confers Resistance To: ampicillinpiperacillincephalothincefoxitinceftazidimecefepimeceftriaxoneimipenemmeropenemertapenemaztreonam
Organisms Tested In: • Escherichia coli
• Pseudomonas aeruginosa
Validation Method: saturation mutagenesis and kinetic analysis

307

Efficacy of calcium-EDTA as an inhibitor for metallo-beta-lactamase in a mouse model of Pseudomonas aeruginosa pneumonia.

PMID 20713659 · 2010

The study demonstrates that calcium-EDTA effectively inhibits metallo-beta-lactamases (MBLs) in Pseudomonas aeruginosa, reducing the minimum inhibitory concentrations (MICs) of imipenem in MBL-producing strains. This suggests that calcium-EDTA could enhance the efficacy of β-lactam antibiotics against MBL-producing pathogens.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: confers resistance to β-lactam antibiotics by hydrolyzing them
Confers Resistance To: imipenem
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: MIC testing with and without Ca-EDTA

308

Carbapenem Heteroresistance in VIM-1-producing Klebsiella pneumoniae isolates belonging to the same clone: consequences for routine susceptibility testing.

PMID 20844213 · 2010

The study identifies the VIM-1 metallo-beta-lactamase as a cause of carbapenem heteroresistance in Klebsiella pneumoniae isolates, highlighting challenges in detecting this resistance mechanism using routine susceptibility testing methods.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: PCR amplification and sequencing

309

Comment on: role of changes in the L3 loop of the active site in the evolution of enzymatic activity of VIM-type metallo-β-lactamases.

PMID 20961909 · 2011

Gene Information

Gene Name: blaVIM
Allele: blaVIM-23
Encodes: subclass B1 metallo-beta-lactamase VIM-23
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: GQ242167.1
Protein Accession: ACT33323.1
Notes: Subclass B1

310

Comment on: role of changes in the L3 loop of the active site in the evolution of enzymatic activity of VIM-type metallo-β-lactamases.

PMID 20961909 · 2011

Gene Information

Gene Name: blaVIM
Allele: blaVIM-23
Encodes: subclass B1 metallo-beta-lactamase VIM-23
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: GQ242167.1
Protein Accession: ACT33323.1
Notes: Subclass B1

311

Comment on: role of changes in the L3 loop of the active site in the evolution of enzymatic activity of VIM-type metallo-β-lactamases.

PMID 20961909 · 2011

Gene Information

Gene Name: blaVIM
Allele: blaVIM-23
Encodes: subclass B1 metallo-beta-lactamase VIM-23, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: GQ242167.1
Protein Accession: ACT33323.1
Notes: Subclass B1, ARO:3002293

312

Metallo-beta-lactamases among imipenem-resistant Pseudomonas aeruginosa in a Brazilian university hospital.

PMID 21049207 · 2010

The study identified blaSPM-1 and blaVIM-2 as the primary metallo-beta-lactamase genes responsible for imipenem resistance in Pseudomonas aeruginosa isolates, with blaSPM-1 being the most prevalent.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Brazil
Validation Method: PCR detection

313

Biochemical and structural characterization of the subclass B1 metallo-beta-lactamase VIM-4.

PMID 21149620 · 2011

The study characterizes the subclass B1 metallo-beta-lactamase VIM-4, which confers resistance to carbapenems, cephalosporins, and penicillins. VIM-4 was expressed in E. coli and biochemically and structurally analyzed.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: subclass B1 metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenemscephalosporinspenicillin
Organisms Tested In: • Escherichia coli
• Pseudomonas aeruginosa
• Acinetobacter baumannii
Geographic Location: Greece|Italy|Sweden|Hungary|Poland|Belgium|Tunisia|United States|Australia
Validation Method: expression in E. coli and biochemical characterization
Sequence Accession: 2whg

314

Novel VIM metallo-beta-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia.

The study reports the emergence of a novel VIM metallo-beta-lactamase variant, VIM-24, in a Klebsiella pneumoniae isolate from Colombia, which confers resistance to carbapenems.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-24
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: Colombia
Validation Method: sequencing and susceptibility testing
Sequence Accession: HM855205

315

Novel VIM metallo-beta-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-24
Encodes: subclass B1 metallo-beta-lactamase VIM-24
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: HM855205.1
Protein Accession: ADL27533.1
Notes: Subclass B1

316

Novel VIM metallo-beta-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-24
Encodes: subclass B1 metallo-beta-lactamase VIM-24
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: HM855205.1
Protein Accession: ADL27533.1
Notes: Subclass B1

317

Novel VIM metallo-beta-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-24
Encodes: subclass B1 metallo-beta-lactamase VIM-24, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: HM855205.1
Protein Accession: ADL27533.1
Notes: Subclass B1, ARO:3002294

318

Novel VIM metallo-beta-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-24
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: HM855205
Notes: Subclass B1

319

Characterization of metallo-beta-lactamase VIM-27, an A57S mutant of VIM-1 associated with Klebsiella pneumoniae ST147.

The study characterizes VIM-27, a metallo-beta-lactamase variant with reduced activity against certain beta-lactam antibiotics compared to VIM-1.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-27
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of beta-lactam antibiotics
Confers Resistance To: imipenemcefepimecefotaximecefoxitin
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
Geographic Location: Greece
Validation Method: expression in E. coli and MIC determination
Sequence Accession: HQ858608

320

Characterization of metallo-beta-lactamase VIM-27, an A57S mutant of VIM-1 associated with Klebsiella pneumoniae ST147.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-27
Encodes: subclass B1 metallo-beta-lactamase VIM-27
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: HQ858608.1
Protein Accession: ADX78234.1
Notes: Subclass B1

321

Characterization of metallo-beta-lactamase VIM-27, an A57S mutant of VIM-1 associated with Klebsiella pneumoniae ST147.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-27
Encodes: subclass B1 metallo-beta-lactamase VIM-27
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: HQ858608.1
Protein Accession: ADX78234.1
Notes: Subclass B1

322

Characterization of metallo-beta-lactamase VIM-27, an A57S mutant of VIM-1 associated with Klebsiella pneumoniae ST147.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-27
Encodes: subclass B1 metallo-beta-lactamase VIM-27, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: HQ858608.1
Protein Accession: ADX78234.1
Notes: Subclass B1, ARO:3002297

323

Characterization of metallo-beta-lactamase VIM-27, an A57S mutant of VIM-1 associated with Klebsiella pneumoniae ST147.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-27
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: HQ858608
Notes: Subclass B1

324

A novel VIM-type metallo-beta-lactamase (VIM-14) in a Pseudomonas aeruginosa clinical isolate from a neonatal intensive care unit.

A novel VIM-type metallo-beta-lactamase, VIM-14, was identified in a Pseudomonas aeruginosa isolate from a neonatal intensive care unit. VIM-14 differs from VIM-4 by a G31S mutation and is part of a class 1 integron carrying additional resistance genes.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-14
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Escherichia coli
Geographic Location: Italy
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AY635904|FJ445404

325

A novel VIM-type metallo-beta-lactamase (VIM-14) in a Pseudomonas aeruginosa clinical isolate from a neonatal intensive care unit.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-14
Encodes: subclass B1 metallo-beta-lactamase VIM-14
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY635904.1
Protein Accession: AAT48653.1
Notes: Subclass B1

326

A novel VIM-type metallo-beta-lactamase (VIM-14) in a Pseudomonas aeruginosa clinical isolate from a neonatal intensive care unit.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-14
Encodes: subclass B1 metallo-beta-lactamase VIM-14
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY635904.1
Protein Accession: AAT48653.1
Notes: Subclass B1

327

A novel VIM-type metallo-beta-lactamase (VIM-14) in a Pseudomonas aeruginosa clinical isolate from a neonatal intensive care unit.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-14
Encodes: subclass B1 metallo-beta-lactamase VIM-14, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AY635904.1
Protein Accession: AAT48653.1
Notes: Subclass B1, ARO:3002284

328

A novel VIM-type metallo-beta-lactamase (VIM-14) in a Pseudomonas aeruginosa clinical isolate from a neonatal intensive care unit.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-14
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: FJ445404
Notes: Subclass B1

329

Molecular characterization of VIM-producing Klebsiella pneumoniae from Scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-26
Encodes: subclass B1 metallo-beta-lactamase VIM-26
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: FR748153.1
Protein Accession: CBY80143.1
Notes: Subclass B1

330

Molecular characterization of VIM-producing Klebsiella pneumoniae from Scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-26
Encodes: subclass B1 metallo-beta-lactamase VIM-26
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: FR748153.1
Protein Accession: CBY80143.1
Notes: Subclass B1

331

Molecular characterization of VIM-producing Klebsiella pneumoniae from Scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-26
Encodes: subclass B1 metallo-beta-lactamase VIM-26, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: FR748153.1
Protein Accession: CBY80143.1
Notes: Subclass B1, ARO:3002296

332

Molecular characterization of VIM-producing Klebsiella pneumoniae from Scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-26
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: FR748153
Notes: Subclass B1

333

Early detection of colonization by VIM-1-producing Klebsiella pneumoniae and NDM-1-producing Escherichia coli in two children returning to France.

PMID 21653781 · 2011

The study reports the early detection of VIM-1-producing Klebsiella pneumoniae and NDM-1-producing Escherichia coli in two children returning to France, highlighting the importance of identifying metallo-beta-lactamase-producing organisms for effective infection control.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
Geographic Location: France|Egypt|India
Validation Method: PCR amplification and sequencing

334

OXA beta-lactamase-mediated carbapenem resistance in Acinetobacter baumannii.

PMID 21860108 · 2011

The study identified blaOXA-23-like and blaOXA-51-like genes as the most common OXA carbapenamases, and blaVIM as the most common metallo-beta-lactamase contributing to carbapenem resistance in Acinetobacter baumannii.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: carbapenem resistance
Confers Resistance To: carbapenems
Organisms Tested In: • Acinetobacter baumannii
Validation Method: PCR and gene sequencing

335

Nosocomial outbreak of VIM-1-producing Klebsiella pneumoniae isolates of multilocus sequence type 15: molecular basis, clinical risk factors, and outcome.

PMID 22005997 · 2012

The study identifies blaVIM-1 as a gene responsible for carbapenem resistance in Klebsiella pneumoniae isolates during a nosocomial outbreak. The gene was found in a class 1 integron and was associated with multidrug-resistant strains.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: imipenemmeropenemertapenem
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: Spain
Validation Method: PCR and sequencing

336

Antimicrobial resistance determinants in imipenem-nonsusceptible Acinetobacter calcoaceticus-baumannii complex isolated in Daejeon, Korea.

PMID 22016680 · 2011

The study identified various antimicrobial resistance genes including blaOXA-51-like, blaOXA-23, blaIMP-1, blaVIM-2, aac(6')-Ib, aph(3')-Ia, aph(3')-VI, and armA in imipenem-nonsusceptible Acinetobacter calcoaceticus-baumannii complex isolates. Additionally, mutations in gyrA and parC were found to confer fluoroquinolone resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Acinetobacter genomic species 3
• Acinetobacter genomic species 13TU
Geographic Location: Daejeon, Korea
Validation Method: PCR and sequencing

337

Multidrug-resistant Acinetobacter spp.: increasingly problematic nosocomial pathogens.

PMID 22028150 · 2011

The study characterizes multiple AMR genes and mutations in Acinetobacter spp., including OXA-type carbapenemases, aminoglycoside-modifying enzymes, and fluoroquinolone resistance genes, highlighting the increasing challenge of multidrug-resistant Acinetobacter infections.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: carbapenem-hydrolyzing
Confers Resistance To: carbapenems
Organisms Tested In: • Acinetobacter spp.
Geographic Location: Korea
Validation Method: experimental validation through cloning and MIC testing

338

Nosocomial outbreak of imipenem-resistant Pseudomonas aeruginosa producing VIM-2 metallo-beta-lactamase in a kidney transplantation unit.

PMID 22035284 · 2011

The study identifies the VIM-2 metallo-beta-lactamase as the primary mechanism of imipenem resistance in a nosocomial outbreak of Pseudomonas aeruginosa in a kidney transplantation unit.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Tunisia
Validation Method: PCR and imipenem-EDTA synergy test

339

Interplay between mutational and horizontally acquired resistance mechanisms and its association with carbapenem resistance amongst extensively drug-resistant Pseudomonas aeruginosa (XDR-PA).

PMID 22079532 · 2012

The study identified blaVIM-3 and blaVIM-2 as the primary acquired resistance mechanisms contributing to carbapenem resistance in XDR-PA isolates, along with mutational mechanisms involving decreased oprD expression and overexpression of mexA.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-3
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Taiwan
Validation Method: PCR and sequencing

340

Interplay between mutational and horizontally acquired resistance mechanisms and its association with carbapenem resistance amongst extensively drug-resistant Pseudomonas aeruginosa (XDR-PA).

PMID 22079532 · 2012

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Taiwan
Validation Method: PCR and sequencing

341

Effective antibiotics in combination against extreme drug-resistant Pseudomonas aeruginosa with decreased susceptibility to polymyxin B.

PMID 22162759 · 2011

The study identifies metallo-beta-lactamase genes (blaIMP and blaVIM) and other resistance genes (VEB-1 and OXA-10) in XDR-PA isolates, highlighting the need for combination therapies against these resistant strains.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Singapore
Validation Method: PCR assay

342

Phenotypic Screening of Carbapenemases and Associated β-Lactamases in Carbapenem-Resistant Enterobacteriaceae.

PMID 22259214 · 2012

The study identifies and characterizes various carbapenemases, including blaIMP, blaVIM, blaNDM-1, blaKPC, and blaOXA-48, in carbapenem-resistant Enterobacteriaceae through phenotypic testing with inhibitor-impregnated agar.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: carbapenemase
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacteriaceae
Validation Method: phenotypic testing with inhibitor-impregnated agar

343

Mechanisms of resistance and clinical relevance of resistance to β-lactams, glycopeptides, and fluoroquinolones.

PMID 22305032 · 2012

The paper discusses the mechanisms of resistance to β-lactams, glycopeptides, and fluoroquinolones, highlighting the role of beta-lactamases such as TEM, SHV, CTX-M, KPC, VIM, and NDM, glycopeptide resistance operons like vanA and vanB, and other resistance genes such as ermB, mecA, qnrA, and aac(6')-Ib.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: beta lactams
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: experimental validation

344

Carbapenem resistance among Escherichia coli and Klebsiella pneumoniae in a tertiary care hospital in south India.

PMID 22361769 · 2012

The study identified blaNDM and blaVIM genes as the primary mechanisms of carbapenem resistance in E. coli and K. pneumoniae isolates.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Escherichia coli
• Klebsiella pneumoniae
Geographic Location: south India
Validation Method: polymerase chain reaction (PCR) and DNA sequencing

345

Detection and characterization of VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in a clinical isolate of Enterobacter cloacae.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-31
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacter cloacae
• Escherichia coli
Validation Method: purified enzyme activity and MIC testing

346

Detection and characterization of VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in a clinical isolate of Enterobacter cloacae.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-31
Encodes: subclass B1 metallo-beta-lactamase VIM-31
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: JN982330.1
Protein Accession: AFK24647.1
Notes: Subclass B1

347

Detection and characterization of VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in a clinical isolate of Enterobacter cloacae.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-31
Encodes: subclass B1 metallo-beta-lactamase VIM-31
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: JN982330.1
Protein Accession: AFK24647.1
Notes: Subclass B1

348

Detection and characterization of VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in a clinical isolate of Enterobacter cloacae.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-31
Encodes: subclass B1 metallo-beta-lactamase VIM-31, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: JN982330.1
Protein Accession: AFK24647.1
Notes: Subclass B1, ARO:3002301

349

Detection and characterization of VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in a clinical isolate of Enterobacter cloacae.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-31
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Enterobacter cloacae
Sequence Accession: JN982330
Notes: Subclass B1

350

Fecal carriage of carbapenemase-producing Enterobacteriaceae: a hidden reservoir in hospitalized and nonhospitalized patients.

PMID 22403422 · 2012

The study identifies blaVIM-1 as a carbapenemase gene responsible for resistance in various Enterobacteriaceae species, including K. pneumoniae, E. cloacae, E. coli, and C. freundii, highlighting its role in carbapenem resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: carbapenemase
Source Database: Reslit
Mechanism: hydrolysis of carbapenems
Confers Resistance To: imipenemmeropenemertapenemdoripenem
Organisms Tested In: • Klebsiella pneumoniae
• Enterobacter cloacae
• Escherichia coli
• Citrobacter freundii
Geographic Location: Spain
Validation Method: PCR and sequencing

351

The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.

PMID 22536199 · 2012

The paper discusses various virulence factors and mechanisms contributing to the pathogenicity and antibiotic resistance of Acinetobacter baumannii, including biofilm formation, surface polysaccharides, and outer membrane proteins.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Global|India|Spain
Validation Method: cloning and MIC testing

352

Imported Klebsiella pneumoniae carbapenemase-producing K. pneumoniae clones in a Greek hospital: impact of infection control measures for restraining their dissemination.

PMID 22649010 · 2012

The study identifies KPC-2 and VIM-1 carbapenemase-producing K. pneumoniae clones in a Greek hospital and highlights the effectiveness of infection control measures in reducing their dissemination.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenem
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: Greece
Validation Method: PCR and sequencing

353

Comparison of disc and MIC reduction methods with polymerase chain reaction for the detection of metallo-beta-lactamase in Pseudomonas aeruginosa.

PMID 22664432 · 2012

The study identified blaVIM as the prevalent metallo-beta-lactamase gene in Pseudomonas aeruginosa isolates, which confers resistance to carbapenems.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: polymerase chain reaction (PCR)

354

First report of an extensively drug-resistant VIM-2 metallo-beta-lactamase-producing Brevundimonas diminuta clinical isolate.

PMID 22692741 · 2012

The study reports the first clinical isolate of Brevundimonas diminuta producing the VIM-2 metallo-beta-lactamase, which confers resistance to carbapenems.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Brevundimonas diminuta
Geographic Location: Argentina
Validation Method: PCR and sequencing
Sequence Accession: EU497053.1

355

Current epidemiology and growing resistance of gram-negative pathogens.

PMID 22707882 · 2012

The paper highlights the emergence and spread of multidrug-resistant Gram-negative pathogens, focusing on extended-spectrum beta-lactamases (ESBLs) such as CTX-M-15 and CTX-M-14, carbapenemases like KPC-2, VIM-2, and IMP-6, and aminoglycoside-modifying enzymes such as aac(6')-Ib-cr and armA. It emphasizes the global dissemination of these resistance mechanisms and their impact on treatment options.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenem
Organisms Tested In: • Klebsiella pneumoniae
• Serratia marcescens
Geographic Location: Europe|Asia|North America|South America
Validation Method: plasmid-mediated resistance

356

Phenotypic detection of metallo-β-lactamase in imipenem-resistant Pseudomonas aeruginosa.

PMID 22792048 · 2012

The study identifies and characterizes several metallo-beta-lactamase genes (blaIMP-4, blaIMP-7, blaVIM-2, and blaVIM-11) responsible for carbapenem resistance in imipenem-resistant Pseudomonas aeruginosa isolates.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Malaysia
Validation Method: PCR and phenotypic assays

357

Phenotypic detection of metallo-β-lactamase in imipenem-resistant Pseudomonas aeruginosa.

PMID 22792048 · 2012

Gene Information

Gene Name: blaVIM
Allele: blaVIM-11
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Malaysia
Validation Method: PCR and phenotypic assays

358

Characteristics of plasmids in multi-drug-resistant Enterobacteriaceae isolated during prospective surveillance of a newly opened hospital in Iraq.

PMID 22808141 · 2012

The study identified various plasmid-borne antimicrobial resistance genes in multi-drug-resistant Enterobacteriaceae isolates from a newly opened hospital in Iraq, including aminoglycoside, beta-lactam, sulfamethoxazole/trime-thoprim, tetracycline, and chloramphenicol resistance genes.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: ampicillin
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
Geographic Location: Iraq
Validation Method: DNA microarray analysis

359

Evaluation of double-disk potentiation and disk potentiation tests using dipicolinic acid for detection of metallo-beta-lactamase-producing pseudomonas spp. and Acinetobacter spp.

PMID 22837321 · 2012

The study evaluates the effectiveness of dipicolinic acid (DPA) in detecting metallo-beta-lactamase (MBL)-producing Pseudomonas spp. and Acinetobacter spp., identifying blaIMP-6 and blaVIM-2 as significant resistance genes.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: meropenem
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: South Korea
Validation Method: PCR and MIC testing
Sequence Accession: JQ764729

360

Transmission dynamics of carbapenemase-producing Klebsiella pneumoniae and anticipated impact of infection control strategies in a surgical unit.

PMID 22859965 · 2012

The study identifies blaKPC and blaVIM genes as responsible for carbapenem resistance in Klebsiella pneumoniae, highlighting their role in the transmission dynamics within a surgical unit.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: Europe
Validation Method: combined disk synergy test utilizing disks containing meropenem, meropenem/EDTA, meropenem/boronic acid, and meropenem/EDTA+boronic acid

361

Surveillance and molecular epidemiology of Klebsiella pneumoniae isolates that produce carbapenemases: first report of OXA-48-like enzymes in North America.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-33
Encodes: subclass B1 metallo-beta-lactamase VIM-33
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: JX258134.1
Protein Accession: AFP99175.1
Notes: Subclass B1

362

Surveillance and molecular epidemiology of Klebsiella pneumoniae isolates that produce carbapenemases: first report of OXA-48-like enzymes in North America.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-33
Encodes: subclass B1 metallo-beta-lactamase VIM-33
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: JX258134.1
Protein Accession: AFP99175.1
Notes: Subclass B1

363

Surveillance and molecular epidemiology of Klebsiella pneumoniae isolates that produce carbapenemases: first report of OXA-48-like enzymes in North America.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-33
Encodes: subclass B1 metallo-beta-lactamase VIM-33, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: JX258134.1
Protein Accession: AFP99175.1
Notes: Subclass B1, ARO:3002303

364

Surveillance and molecular epidemiology of Klebsiella pneumoniae isolates that produce carbapenemases: first report of OXA-48-like enzymes in North America.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-33
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: JX258134
Notes: Subclass B1

365

Detection of metallo-beta-lactamases producing Acinetobacter baumannii using microbiological assay, disc synergy test and PCR.

PMID 23183473 · 2012

The study identified the bla-VIM gene as the only metallo-beta-lactamase gene detected in carbapenem-resistant Acinetobacter baumannii isolates, highlighting its significance in resistance mechanisms.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Acinetobacter baumannii
Validation Method: PCR

366

First detection of VIM-4 metallo-β-lactamase-producing Citrobacter freundii in China.

PMID 23301229 · 2013

The study reports the first identification of the blaVIM-4 gene in a clinical Citrobacter freundii strain from China, demonstrating carbapenem resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Citrobacter freundii
• Escherichia coli
Geographic Location: China
Validation Method: PCR amplification and nucleotide sequence analysis
Sequence Accession: NCBI:HM137222

367

Emergence of imipenem-resistant gram-negative bacilli in intestinal flora of intensive care patients.

PMID 23318796 · 2013

The study identified blaVIM-2 and blaGES-9 genes in Pseudomonas aeruginosa isolates, which confer resistance to imipenem.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: imipenem
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: France
Validation Method: PCR and sequencing

368

Identification of blaOXA-51-like, blaOXA-58, blaDIM-1, and blaVIM carbapenemase genes in hospital Enterobacteriaceae isolates from Sierra Leone.

The study identifies blaOXA-51-like, blaOXA-58-like, blaDIM-1, and blaVIM carbapenemase genes in hospital Enterobacteriaceae isolates from Sierra Leone, highlighting the presence of these resistance genes in non-Acinetobacter species and emphasizing the need for molecular surveillance of carbapenemase gene circulation.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacter cloacae
• Escherichia coli
• Klebsiella pneumoniae
Geographic Location: Sierra Leone
Validation Method: PCR and DNA sequencing
Sequence Accession: KC004135|KC004136

369

Identification of blaOXA-₅₁-like, blaOXA-₅₈, blaDIM-₁, and blaVIM carbapenemase genes in hospital Enterobacteriaceae isolates from Sierra Leone.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-30
Encodes: subclass B1 metallo-beta-lactamase VIM-30
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JN129451.1
Protein Accession: AET05999.1
Notes: Subclass B1

370

Identification of blaOXA-₅₁-like, blaOXA-₅₈, blaDIM-₁, and blaVIM carbapenemase genes in hospital Enterobacteriaceae isolates from Sierra Leone.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-30
Encodes: subclass B1 metallo-beta-lactamase VIM-30
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JN129451.1
Protein Accession: AET05999.1
Notes: Subclass B1

371

Identification of blaOXA-₅₁-like, blaOXA-₅₈, blaDIM-₁, and blaVIM carbapenemase genes in hospital Enterobacteriaceae isolates from Sierra Leone.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-30
Encodes: subclass B1 metallo-beta-lactamase VIM-30, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JN129451.1
Protein Accession: AET05999.1
Notes: Subclass B1, ARO:3002300

372

Identification and characterization of metallo-β-lactamases producing Pseudomonas aeruginosa clinical isolates in University Hospital from Zanjan Province, Iran.

PMID 23748890 · 2013

The study identified blaIMP and blaVIM genes in Pseudomonas aeruginosa isolates from Zanjan Province, Iran, highlighting their role in imipenem resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenem
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Iran
Validation Method: PCR and sequencing
Sequence Accession: JQ766528|JQ766529|JQ766530

373

Verona integron-encoded metallo-β-lactamase 1 in Enterobacteria, Ontario, Canada.

PMID 23763841 · 2013

The study reports the detection of VIM-1, a metallo-β-lactamase, in four Enterobacteriaceae isolates from Ontario, Canada, highlighting the emergence of multidrug-resistant clones carrying this resistance gene.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Escherichia coli
• Enterobacter cloacae
Geographic Location: Ontario, Canada
Validation Method: PCR and sequencing

374

beta-lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula.

PMID 23824364 · 2013

The study identifies various beta-lactamase genes, including CTX-M-15, CTX-M-14, CTX-M-9, SHV-12, SHV-5, TEM-1, VEB-1, GES-1, GES-5, GES-11, PER-1, OXA-48, NDM-1, VIM-2, OXA-23, OXA-40, OXA-58, and OXA-181, which confer resistance to β-lactam antibiotics in Gram-negative pathogens from the Arabian Peninsula.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenem
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Arabian Peninsula|Saudi Arabia|United Arab Emirates|Kuwait|Oman|Qatar|Bahrain
Validation Method: molecular analysis

375

Impact of manure fertilization on the abundance of antibiotic-resistant bacteria and frequency of detection of antibiotic resistance genes in soil and on vegetables at harvest.

PMID 23851089 · 2013

The study identified several antibiotic resistance genes in soil and on vegetables, including genes conferring resistance to tetracycline, aminoglycosides, erythromycin, sulfamethoxazole, and beta-lactams. The presence of these genes was influenced by manure fertilization, with certain genes more frequently detected in manured soils.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: ceftazidimemeropenem
Organisms Tested In: • Escherichia coli
Geographic Location: Canada
Validation Method: PCR detection

376

DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.

PMID 23856783 · 2013

The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Germany
Validation Method: microarray analysis

377

Detection of VIM-34, a novel VIM-1 variant identified in the intercontinental ST15 Klebsiella pneumoniae clone.

The study reports the identification of VIM-34, a novel VIM-1 variant in the intercontinental ST15 Klebsiella pneumoniae clone, which confers resistance to carbapenems.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-34
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
Geographic Location: Portugal
Validation Method: cloning in E. coli DH5α + MIC testing
Sequence Accession: JX013656

378

Detection of VIM-34, a novel VIM-1 variant identified in the intercontinental ST15 Klebsiella pneumoniae clone.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-34
Encodes: subclass B1 metallo-beta-lactamase VIM-34
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: JX013656.1
Protein Accession: AFN88953.1
Notes: Subclass B1

379

Detection of VIM-34, a novel VIM-1 variant identified in the intercontinental ST15 Klebsiella pneumoniae clone.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-34
Encodes: subclass B1 metallo-beta-lactamase VIM-34
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: JX013656.1
Protein Accession: AFN88953.1
Notes: Subclass B1

380

Detection of VIM-34, a novel VIM-1 variant identified in the intercontinental ST15 Klebsiella pneumoniae clone.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-34
Encodes: subclass B1 metallo-beta-lactamase VIM-34, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: JX013656.1
Protein Accession: AFN88953.1
Notes: Subclass B1, ARO:3002304

381

Detection of VIM-34, a novel VIM-1 variant identified in the intercontinental ST15 Klebsiella pneumoniae clone.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-34
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: JX013656
Notes: Subclass B1

382

An in silico approach for understanding the molecular evolution of clinically important metallo-beta-lactamases.

PMID 23954421 · 2013

Gene Information

Gene Name: blaVIM
Allele: blaVIM-29
Encodes: subclass B1 metallo-beta-lactamase VIM-29
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Escherichia coli
Sequence Accession: JX311308.1
Protein Accession: AFP99885.1
Notes: Subclass B1

383

An in silico approach for understanding the molecular evolution of clinically important metallo-beta-lactamases.

PMID 23954421 · 2013

Gene Information

Gene Name: blaVIM
Allele: blaVIM-29
Encodes: subclass B1 metallo-beta-lactamase VIM-29
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Escherichia coli
Sequence Accession: JX311308.1
Protein Accession: AFP99885.1
Notes: Subclass B1

384

An in silico approach for understanding the molecular evolution of clinically important metallo-beta-lactamases.

PMID 23954421 · 2013

Gene Information

Gene Name: blaVIM
Allele: blaVIM-29
Encodes: subclass B1 metallo-beta-lactamase VIM-29, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Escherichia coli
Sequence Accession: JX311308.1
Protein Accession: AFP99885.1
Notes: Subclass B1, ARO:3002299

385

Detection of Colonization by Carbapenemase-Producing Gram-Negative Bacilli in Patients by Use of the Xpert MDRO Assay

PMID 24006011 · 2013

The study evaluated the Xpert MDRO assay for detecting blaKPC, blaNDM, and blaVIM carbapenem resistance genes in clinical samples, demonstrating high sensitivity and specificity for identifying carbapenemase-producing organisms.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacteriaceae
• Pseudomonas aeruginosa
• Acinetobacter species
Geographic Location: United States|Spain
Validation Method: PCR assay and DNA sequencing

386

Detection of CMY-99, a novel acquired AmpC-Type beta-lactamase, and VIM-1 in Proteus mirabilis isolates in Bulgaria.

PMID 24165184 · 2014

The study reports the identification of CMY-99, a novel AmpC-type beta-lactamase, and VIM-1, a metallo-beta-lactamase, in Proteus mirabilis isolates from Bulgaria, highlighting the emergence of multidrug-resistant strains.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenem
Organisms Tested In: • Proteus mirabilis
Geographic Location: Bulgaria
Validation Method: PCR and sequencing
Sequence Accession: KF305673

387

Effect of metallo-β-lactamase production and multidrug resistance on clinical outcomes in patients with Pseudomonas aeruginosa bloodstream infection: a retrospective cohort study.

PMID 24176052 · 2013

The study identified VIM-2 and IMP-8 metallo-beta-lactamase genes in Pseudomonas aeruginosa isolates, which conferred resistance to carbapenems.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Germany
Validation Method: PCR and sequencing

388

Multi-centre evaluation of real-time multiplex PCR for detection of carbapenemase genes OXA-48, VIM, IMP, NDM and KPC.

PMID 24422880 · 2014

The study presents a real-time multiplex PCR assay for detecting the most prevalent carbapenemase genes, including blaOXA-48, blaVIM, blaIMP, blaNDM, and blaKPC, demonstrating high sensitivity and specificity.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: carbapenemase
Source Database: Reslit
Mechanism: hydrolysis of carbapenems
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Klebsiella pneumoniae
Validation Method: real-time PCR assay

389

Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-38
Encodes: subclass B1 metallo-beta-lactamase VIM-38
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KC469971.2
Protein Accession: AGE83081.2
Notes: Subclass B1

390

Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-38
Encodes: subclass B1 metallo-beta-lactamase VIM-38
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KC469971.2
Protein Accession: AGE83081.2
Notes: Subclass B1

391

Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-38
Encodes: subclass B1 metallo-beta-lactamase VIM-38, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KC469971.2
Protein Accession: AGE83081.2
Notes: Subclass B1, ARO:3002308

392

Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-38
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: KC469971
Notes: Subclass B1

393

Evaluation of phenotypic detection methods for metallo-β-lactamases (MBLs) in clinical isolates of Pseudomonas aeruginosa.

PMID 24452967 · 2014

The study evaluated phenotypic detection methods for metallo-beta-lactamases (MBLs) in Pseudomonas aeruginosa clinical isolates, identifying blaIMP and blaVIM genes as the primary MBL producers.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Germany
Validation Method: multiplex PCR

394

Modified CLSI extended-spectrum beta-lactamase (ESBL) confirmatory test for phenotypic detection of ESBLs among Enterobacteriaceae producing various beta-lactamases.

PMID 24574283 · 2014

The study evaluated a modified CLSI ESBL confirmatory test for the phenotypic detection of extended-spectrum beta-lactamases (ESBLs) among Enterobacteriaceae producing various beta-lactamases, including KPC, VIM, NDM, and OXA-48. The modified test significantly improved the sensitivity and specificity of ESBL detection compared to the standard CLSI test.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolyzes carbapenems
Confers Resistance To: meropenemimipenemertapenem
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
• Enterobacter aerogenes
• Enterobacter cloacae
• Proteus mirabilis
• Providencia stuartii
• Serratia marcescens
Geographic Location: Greece
Validation Method: phenotypic detection using modified CLSI ESBL confirmatory test

395

Phenotypic and Genetic Characterization of Carbapenemase and ESBLs Producing Gram-negative Bacteria (GNB) Isolated from Patients with Cystic Fibrosis (CF) in Tehran Hospitals.

PMID 24596716 · 2014

The study identified the presence of ESBLs and carbapenemase genes, including blaCTX-M, blaIMP-1, blaVIM-1, and blaVIM-2, in Gram-negative bacteria isolated from cystic fibrosis patients in Tehran hospitals.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenem
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Tehran
Validation Method: PCR and phenotypic testing

396

Phenotypic and Genetic Characterization of Carbapenemase and ESBLs Producing Gram-negative Bacteria (GNB) Isolated from Patients with Cystic Fibrosis (CF) in Tehran Hospitals.

PMID 24596716 · 2014

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenem
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Tehran
Validation Method: PCR and phenotypic testing

397

Epidemiology and carbapenem resistance mechanisms of carbapenem-non-susceptible Pseudomonas aeruginosa collected during 2009-11 in 14 European and Mediterranean countries.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-36
Encodes: subclass B1 metallo-beta-lactamase VIM-36
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JX982635.1
Protein Accession: AGC50806.1
Notes: Subclass B1

398

Epidemiology and carbapenem resistance mechanisms of carbapenem-non-susceptible Pseudomonas aeruginosa collected during 2009-11 in 14 European and Mediterranean countries.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-36
Encodes: subclass B1 metallo-beta-lactamase VIM-36
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JX982635.1
Protein Accession: AGC50806.1
Notes: Subclass B1

399

Epidemiology and carbapenem resistance mechanisms of carbapenem-non-susceptible Pseudomonas aeruginosa collected during 2009-11 in 14 European and Mediterranean countries.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-36
Encodes: subclass B1 metallo-beta-lactamase VIM-36, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JX982635.1
Protein Accession: AGC50806.1
Notes: Subclass B1, ARO:3002306

400

Epidemiology and carbapenem resistance mechanisms of carbapenem-non-susceptible Pseudomonas aeruginosa collected during 2009-11 in 14 European and Mediterranean countries.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-37
Encodes: subclass B1 metallo-beta-lactamase VIM-37
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JX982636.1
Protein Accession: AGC50807.1
Notes: Subclass B1

401

Epidemiology and carbapenem resistance mechanisms of carbapenem-non-susceptible Pseudomonas aeruginosa collected during 2009-11 in 14 European and Mediterranean countries.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-37
Encodes: subclass B1 metallo-beta-lactamase VIM-37
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JX982636.1
Protein Accession: AGC50807.1
Notes: Subclass B1

402

Epidemiology and carbapenem resistance mechanisms of carbapenem-non-susceptible Pseudomonas aeruginosa collected during 2009-11 in 14 European and Mediterranean countries.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-37
Encodes: subclass B1 metallo-beta-lactamase VIM-37, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JX982636.1
Protein Accession: AGC50807.1
Notes: Subclass B1, ARO:3002307

403

Epidemiology and carbapenem resistance mechanisms of carbapenem-non-susceptible Pseudomonas aeruginosa collected during 2009-11 in 14 European and Mediterranean countries.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-36
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JX982635
Notes: Subclass B1

404

Epidemiology and carbapenem resistance mechanisms of carbapenem-non-susceptible Pseudomonas aeruginosa collected during 2009-11 in 14 European and Mediterranean countries.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-37
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JX982636
Notes: Subclass B1

405

Evaluation of an automated rapid diagnostic assay for detection of Gram-negative bacteria and their drug-resistance genes in positive blood cultures.

PMID 24705449 · 2014

The study evaluated the Verigene BC-GN assay for rapid detection of Gram-negative bacteria and their drug-resistance genes in positive blood cultures. It successfully detected 9 bacterial species and 9 drug resistance genes, including bla CTX-M, bla IMP, bla KPC, bla NDM, bla OXA-23, bla OXA-24/40, bla OXA-48, bla OXA-58, and bla VIM.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenemertapenemcefotaximeceftazidimeampicillinamoxicillin clavulanic acidaztreonam
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Japan
Validation Method: PCR and/or DNA sequencing

406

Antimicrobial resistance pattern and their beta-lactamase encoding genes among Pseudomonas aeruginosa strains isolated from cancer patients.

PMID 24707471 · 2014

The study identified blaVIM-2, blaOXA-10, blaVEB-1, blaNDM, and blaIMP-1 as the most prevalent beta-lactamase genes in P. aeruginosa isolates from Egypt, contributing to resistance against imipenem and ceftazidime.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemceftazidime
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Egypt
Validation Method: PCR and phenotypic detection

407

CarbAcineto NP test for rapid detection of carbapenemase-producing Acinetobacter spp.

PMID 24759709 · 2014

The study introduces the CarbAcineto NP test, a modified version of the Carba NP test, for the rapid and accurate detection of carbapenemase-producing Acinetobacter spp. The test successfully identifies various carbapenemases including OXA-23, OXA-24/OXA-40, OXA-58, OXA-143, GES-11, GES-14, NDM-1, NDM-2, IMP-1, IMP-4, VIM-4, and SIM-1.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Acinetobacter sp. genomospecies
Validation Method: CarbAcineto NP test

408

Use of imipenem to detect KPC, NDM, OXA, IMP, and VIM carbapenemase activity from gram-negative rods in 75 minutes using liquid chromatography-tandem mass spectrometry.

PMID 24789180 · 2014

The study developed an LC-MS/MS assay to detect carbapenemase activity from gram-negative rods, demonstrating that imipenem showed high sensitivity and specificity for detecting KPC, NDM, OXA, IMP, and VIM carbapenemases.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: carbapenemase
Source Database: Reslit
Mechanism: hydrolysis of carbapenems
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacteriaceae
• non-Enterobacteriaceae
Validation Method: LC-MS/MS assay

409

His224 Alters the R2 Drug Binding Site and Phe218 Influences the Catalytic Efficiency of the Metallo-β-Lactamase VIM-7.

PMID 24913158 · 2014

The study characterizes the metallo-β-lactamase VIM-7 and identifies mutations (His224Y and Phe218Y) that enhance its catalytic efficiency and thermostability against carbapenems and beta-lactams.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-7
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: mutational analysis, enzyme kinetics, crystal structures, thermostability, and docking experiments
Sequence Accession: 4D1T|4D1U|4D1V|4D1W

410

Bactericidal activity, absence of serum effect, and time-kill kinetics of ceftazidime-avibactam against beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa.

PMID 24957838 · 2014

The study characterizes the resistance mechanisms conferred by bla VIM and bla OXA-23 genes in Pseudomonas aeruginosa, showing that ceftazidime-avibactam effectively reduces the MICs of ceftazidime against these isolates.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: ceftazidime
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: MIC testing

411

Molecular Characterization of Carbapenem Resistant Isolates of Acinetobacter baumannii in An Intensive Care Unit of A Tertiary Care Centre at Central India.

PMID 24995182 · 2014

The study identified blaOXA-23, blaOXA-51, blaOXA-58, and blaVIM genes as major contributors to carbapenem resistance in Acinetobacter baumannii isolates from an ICU in India.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: Metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenem
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: India
Validation Method: PCR and sequencing

412

First detection of a metallo-beta-lactamase producing Serratia marcescens in a European university hospital.

PMID 25008843 · 2014

The study reports the first detection of a metallo-beta-lactamase producing Serratia marcescens in a European university hospital, highlighting the emergence of carbapenem-resistant strains.

Gene Information

Gene Name: blaVIM
Allele: bla(VIM-1)
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of β-lactam antibiotics
Confers Resistance To: imipenem
Organisms Tested In: • Serratia marcescns
Geographic Location: Europe
Validation Method: molecular characterization

413

Rapid identification of carbapenemase genes in gram-negative bacteria with an oligonucleotide microarray-based assay.

The study presents a microarray-based assay for the rapid identification of carbapenemase genes in Gram-negative bacteria, including bla KPC, bla VIM, bla NDM, bla GIM, bla OXA-23, bla OXA-48-group, bla OXA-51, bla OXA-58, and various beta-lactamase genes such as bla OXA-1, bla OXA-2, bla OXA-7, bla OXA-9, bla OXA-10, bla CTX-M1, and bla CTX-M15.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Klebsiella pneumoniae
Geographic Location: Germany
Validation Method: microarray-based assay

414

Rapid identification of carbapenemase genes in gram-negative bacteria with an oligonucleotide microarray-based assay.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacteriaceae
• Pseudomonadales
Geographic Location: Germany
Validation Method: PCR

415

Rapid identification of carbapenemase genes in gram-negative bacteria with an oligonucleotide microarray-based assay.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacteriaceae
• Pseudomonadales
Geographic Location: Germany
Validation Method: PCR

416

Rapid identification of carbapenemase genes in gram-negative bacteria with an oligonucleotide microarray-based assay.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacteriaceae
• Pseudomonadales
Geographic Location: Germany
Validation Method: PCR

417

Extensively drug-resistant pseudomonas aeruginosa isolates containing blaVIM-2 and elements of Salmonella genomic island 2: a new genetic resistance determinant in Northeast Ohio.

PMID 25070102 · 2014

The study identifies blaVIM-2 as a novel genetic resistance determinant in extensively drug-resistant Pseudomonas aeruginosa isolates from Northeast Ohio, highlighting a new recombination event involving Salmonella genomic island 2.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Northeast Ohio
Validation Method: genetic testing for bla MBL s
Sequence Accession: KJ463833

418

Carbapenem Resistance among Enterobacter Species in a Tertiary Care Hospital in Central India.

PMID 25180095 · 2014

The study identified bla VIM-2, bla VIM-6, and bla NDM-1 as important carbapenem resistance genes in Enterobacter species, highlighting the role of plasmid-mediated transfer in the spread of resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacter aerogenes
• Enterobacter cloacae
• Enterobacter cloacae complex
Geographic Location: India
Validation Method: PCR and sequencing

419

Carbapenem Resistance among Enterobacter Species in a Tertiary Care Hospital in Central India.

PMID 25180095 · 2014

Gene Information

Gene Name: blaVIM
Allele: blaVIM-6
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacter spp.
• Enterobacter aerogenes
• Enterobacter cloacae
• Enterobacter cloacae complex
Geographic Location: India
Validation Method: PCR and sequencing

420

Whole genome and transcriptome analyses of environmental antibiotic sensitive and multi-resistant Pseudomonas aeruginosa isolates exposed to waste water and tap water.

PMID 25186059 · 2015

The study identifies multiple AMR genes and mutations in the multi-resistant P. aeruginosa isolate PA49, including aac(6')-Ib, aadB, blaVIM-2, ampC, and mutations in gyrA, parC, and oprD, which confer resistance to various antibiotics.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: ceftazidimepiperacillin tazobactam
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Germany
Validation Method: genome analysis
Sequence Accession: gi|32470063|gi|378773997|gi|489251134|gi|88853419|gi|489211498|gi|489217979|gi|407937916|SRP041029|SRP041030|SRP041150|SRP041151

421

Population structure of clinical Pseudomonas aeruginosa from West and Central African countries.

PMID 25187957 · 2014

The study identified VIM-2, GES-1, and GES-9 beta-lactamase genes in Pseudomonas aeruginosa isolates from West and Central Africa, highlighting the presence of both international clonal complexes and local distinct STs carrying these resistance genes.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: West Africa|Central Africa
Validation Method: PCR and sequencing

422

Identification of a novel metallo-β-lactamase VIM-28 located within unusual arrangement of class 1 integron structure in Pseudomonas aeruginosa isolates from Egypt.

PMID 25241690 · 2014

Gene Information

Gene Name: blaVIM
Allele: blaVIM-28
Encodes: subclass B1 metallo-beta-lactamase VIM-28
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JF900599.1
Protein Accession: AEI25539.1
Notes: Subclass B1

423

Identification of a novel metallo-β-lactamase VIM-28 located within unusual arrangement of class 1 integron structure in Pseudomonas aeruginosa isolates from Egypt.

PMID 25241690 · 2014

Gene Information

Gene Name: blaVIM
Allele: blaVIM-28
Encodes: subclass B1 metallo-beta-lactamase VIM-28
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JF900599.1
Protein Accession: AEI25539.1
Notes: Subclass B1

424

Identification of a novel metallo-β-lactamase VIM-28 located within unusual arrangement of class 1 integron structure in Pseudomonas aeruginosa isolates from Egypt.

PMID 25241690 · 2014

Gene Information

Gene Name: blaVIM
Allele: blaVIM-28
Encodes: subclass B1 metallo-beta-lactamase VIM-28, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: JF900599.1
Protein Accession: AEI25539.1
Notes: Subclass B1, ARO:3002298

425

Evaluation of clonality and carbapenem resistance mechanisms among Acinetobacter baumannii-Acinetobacter calcoaceticus complex and Enterobacteriaceae isolates collected in European and Mediterranean countries and detection of two novel beta-lactamases, GES-22 and VIM-35.

The study identified two novel beta-lactamases, GES-22 and VIM-35, which confer resistance to various β-lactam antibiotics. GES-22 showed an extended-spectrum beta-lactamase profile, while VIM-35 exhibited a similar susceptibility profile to VIM-1.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-35
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: carbapenemase
Confers Resistance To: doripenemimipenemmeropenem
Organisms Tested In: • Klebsiella oxytoca
• Escherichia coli
Geographic Location: Europe|Mediterranean countries
Validation Method: cloning in E. coli + susceptibility testing
Sequence Accession: JX023441.1

426

Gene Information

Gene Name: blaVIM
Allele: blaVIM-35
Encodes: subclass B1 metallo-beta-lactamase VIM-35
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella oxytoca
Sequence Accession: JX982634.1
Protein Accession: AGC50805.1
Notes: Subclass B1

427

Gene Information

Gene Name: blaVIM
Allele: blaVIM-35
Encodes: subclass B1 metallo-beta-lactamase VIM-35
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella oxytoca
Sequence Accession: JX982634.1
Protein Accession: AGC50805.1
Notes: Subclass B1

428

Gene Information

Gene Name: blaVIM
Allele: blaVIM-35
Encodes: subclass B1 metallo-beta-lactamase VIM-35, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella oxytoca
Sequence Accession: JX982634.1
Protein Accession: AGC50805.1
Notes: Subclass B1, ARO:3002305

429

Gene Information

Gene Name: blaVIM
Allele: blaVIM-35
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella oxytoca
Sequence Accession: JX982634
Notes: Subclass B1

430

Co-existence of beta-lactamases in clinical isolates of Escherichia coli from Kathmandu, Nepal.

PMID 25287013 · 2014

The study reports the high prevalence of bla CTX-M-type ESBL and co-existence of ESBLs and carbapenemases in E. coli isolates from Kathmandu, Nepal. It identifies multiple beta-lactamase genes including bla CTX-M, bla SHV, bla TEM, bla VIM, bla IMP, and bla NDM-1.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenem
Organisms Tested In: • Escherichia coli
Geographic Location: Nepal
Validation Method: PCR and phenotypic confirmation

431

Characterization by phenotypic and genotypic methods of metallo-β‑lactamase‑producing Pseudomonas aeruginosa isolated from patients with cystic fibrosis.

PMID 25323940 · 2015

The study identified blaVIM and blaIMP genes in Pseudomonas aeruginosa isolates from cystic fibrosis patients, which confer resistance to carbapenems and cephalosporins.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenemceftazidime
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: China
Validation Method: duplex PCR

432

Rapid Diagnostic Approaches for Antimicrobial Resistance

PMID 25343142 · 2023

The paper discusses various rapid antimicrobial resistance testing methods, including molecular techniques like qPCR, DNA microarrays, Luminex xMAP, and next-generation sequencing (NGS), highlighting their roles in detecting resistance genes such as blaCTX-M, blaTEM, blaSHV, blaKPC, blaNDM, blaOXA-48, blaVIM, blaIMP, mecA, mecC, vanA, vanB, aacA-aphD, tetK, tetM, ermA, ermC, vatA, vatB, and vatC in different bacterial species.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacteriaceae
Validation Method: molecular testing

433

Evaluation of carbapenemase screening and confirmation tests with Enterobacteriaceae and development of a practical diagnostic algorithm.

PMID 25355766 · 2015

The study identified several carbapenemase genes, including blaKPC, blaVIM, blaNDM, and blaOXA-48, which confer resistance to carbapenems in Enterobacteriaceae. These genes were experimentally validated through genetic detection and phenotypic testing.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: genetic detection and phenotypic testing

434

The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility.

PMID 25367914 · 2015

The study identified several AMR genes and mutations in Pseudomonas aeruginosa, including beta-lactamases (blaVIM-2, blaOXA-2, blaPSE-1), aminoglycoside-modifying enzymes (aac(6')-Ib, aacA7), and efflux pumps (mexAB-oprM, mexXY-oprM). Mutations in gyrA (T83I) and parC (S87L) were associated with fluoroquinolone resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: carbapenem resistance
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Germany|Spain|France|China|United States|Argentina|Canada|Colombia|Croatia|Brazil|Greece|Italy|Israel|India|Portugal|Philippines|Romania|Taiwan
Validation Method: genomic analysis and susceptibility testing
Sequence Accession: PRJNA264310

435

Characterization of Plasmid-Mediated AmpC and Carbapenemases among Iranian Nosocomial Isolates of Klebsiella pneumoniae Using Phenotyping and Genotyping Methods.

PMID 25562041 · 2014

The study identified plasmid-mediated AmpC beta-lactamases (blaMOX, blaCIT) and carbapenemases (blaVIM, blaGES) in clinical isolates of Klebsiella pneumoniae in Iran, highlighting the high prevalence of these resistance mechanisms.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: Iran
Validation Method: multiplex PCR

436

Survey of metallo-β-lactamase-producing Enterobacteriaceae colonizing patients in European ICUs and rehabilitation units, 2008-11.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-39
Encodes: subclass B1 metallo-beta-lactamase VIM-39
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: KF131539.1
Protein Accession: AGS82586.1
Notes: Subclass B1

437

Survey of metallo-β-lactamase-producing Enterobacteriaceae colonizing patients in European ICUs and rehabilitation units, 2008-11.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-39
Encodes: subclass B1 metallo-beta-lactamase VIM-39
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: KF131539.1
Protein Accession: AGS82586.1
Notes: Subclass B1

438

Survey of metallo-β-lactamase-producing Enterobacteriaceae colonizing patients in European ICUs and rehabilitation units, 2008-11.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-39
Encodes: subclass B1 metallo-beta-lactamase VIM-39, VIM beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: KF131539.1
Protein Accession: AGS82586.1
Notes: Subclass B1, ARO:3002309

439

Survey of metallo-β-lactamase-producing Enterobacteriaceae colonizing patients in European ICUs and rehabilitation units, 2008-11.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-39
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: KF131539
Notes: Subclass B1

440

A locked nucleic acid (LNA)-based real-time PCR assay for the rapid detection of multiple bacterial antibiotic resistance genes directly from positive blood culture.

PMID 25775001 · 2015

The study developed an LNA-qPCR assay for the rapid detection of 13 antibiotic resistance genes, including bla CTX-M-1, bla CTX-M-9, bla CMY-2, bla DHA-1, bla OXA-23, bla VIM-2, mecA, vanA, and vanB. The assay showed high specificity and sensitivity, with 91.5% concordance with phenotypic susceptibility testing.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenem
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: China
Validation Method: real-time PCR and DNA sequencing

441

Carbapenem-nonsusceptible Enterobacteriaceae in Taiwan.

PMID 25794144 · 2015

The study identified several carbapenemase genes, including blaKPC-2, blaIMP-8, blaNDM-1, and blaVIM-1, along with extended-spectrum beta-lactamase genes such as CTX-M, SHV, and ampC beta-lactamase genes like DHA and CMY, which contribute to carbapenem resistance in Enterobacteriaceae isolates in Taiwan.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of carbapenems
Confers Resistance To: ertapenemimipenemmeropenem
Organisms Tested In: • Enterobacter cloacae
• Escherichia coli
Geographic Location: Taiwan
Validation Method: detection via multiplex PCR and sequencing

442

The carbapenem inactivation method (CIM), a simple and low-cost alternative for the Carba NP test to assess phenotypic carbapenemase activity in gram-negative rods.

PMID 25798828 · 2015

The study introduces the Carbapenem Inactivation Method (CIM) as a low-cost and effective phenotypic test for detecting carbapenemase activity in Gram-negative bacteria. It identifies several carbapenemase genes including bla OXA-23, bla OXA-48, bla VIM-1, and bla OXA-72.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Proteus mirabilis
Geographic Location: Netherlands
Validation Method: PCR and CIM
Sequence Accession: PRJEB8575

443

Molecular detection of metallo-beta-lactamase gene blaVIM-1 in imipenem-resistant Pseudomonas aeruginosa strains isolated from hospitalized patients in the hospitals of Isfahan.

PMID 25802826 · 2015

The study aimed to detect the metallo-beta-lactamase gene blaVIM-1 in imipenem-resistant P. aeruginosa strains but found that none of the isolates carried this gene.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenem
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Iran
Validation Method: PCR assay

444

Characteristics of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in Korea.

PMID 25844261 · 2015

The study identified blaIMP-6 and blaVIM-2 genes in 5.2% and 1.2% of carbapenem-non-susceptible P. aeruginosa isolates, respectively, indicating their role in carbapenem resistance in Korea.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenem
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Korea
Validation Method: PCR and sequencing

445

Ceftazidime-avibactam activity tested against Enterobacteriaceae isolates from U.S. hospitals (2011 to 2013) and characterization of β-lactamase-producing strains.

PMID 25845862 · 2015

The study evaluated the activity of ceftazidime-avibactam against Enterobacteriaceae isolates and identified blaKPC-2 and blaVIM-4 as resistance genes in K. pneumoniae strains.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: United States
Validation Method: PCR and sequencing

446

Dissemination of VIM-2 producing Pseudomonas aeruginosa ST233 at tertiary care hospitals in Egypt.

PMID 25880997 · 2015

The study identified the blaVIM-2 gene as the most prevalent metallo-beta-lactamase gene among carbapenem-resistant Pseudomonas aeruginosa isolates in Egypt, with 85% of MBL-positive isolates carrying this gene.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of carbapenems
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Egypt
Validation Method: PCR and sequencing
Sequence Accession: KP097713

447

Molecular analysis of the integrons of metallo-β-lactamase-producing Pseudomonas aeruginosa isolates collected by nationwide surveillance programs across Japan.

PMID 25881168 · 2015

The study identifies various metallo-beta-lactamase (MBL) genes, including blaIMP-1, blaIMP-7, blaIMP-10, blaIMP-6, blaIMP-11, blaVIM-1, and a novel fosI gene cassette, in MBL-producing Pseudomonas aeruginosa isolates across Japan.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Japan
Validation Method: PCR and nucleotide sequencing
Sequence Accession: AB901034|AB901035|AB901036|AB901037|AB901038|AB901039|AB901040|AB901041|AB901042|AB901043|AB901044|AB901045|AB901046|AB901047

448

Identification of Gram-Negative Bacteria and Genetic Resistance Determinants from Positive Blood Culture Broths by Use of the Verigene Gram-Negative Blood Culture Multiplex Microarray-Based Molecular Assay.

PMID 25994165 · 2015

The Verigene Gram-Negative Blood Culture (BC-GN) assay effectively identifies Gram-negative bacteria and detects genetic resistance determinants such as bla CTX-M, bla KPC, bla NDM, bla OXA, bla VIM, and bla IMP in positive blood culture broths.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenemscephalosporinspenicillin
Organisms Tested In: • Pseudomonas aeruginosa
• Klebsiella pneumoniae
• Enterobacter spp.
Validation Method: microarray-based detection

449

Metallo-beta-Lactamase VIM-1, SPM-1, and IMP-1 Genes Among Clinical Pseudomonas aeruginosa Species Isolated in Zahedan, Iran.

PMID 26034547 · 2015

The study identified the presence of the blaVIM-1 gene among imipenem-resistant Pseudomonas aeruginosa isolates in Zahedan, Iran, highlighting its significance in carbapenem resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Iran
Validation Method: PCR and E-test

450

Characterization of Carbapenem-Resistant Enterobacteriaceae with High Rate of Autochthonous Transmission in the Arabian Peninsula.

PMID 26110660 · 2015

The study identified bla NDM, bla OXA-48-like, and bla VIM as the primary carbapenemase genes in carbapenem-resistant Enterobacteriaceae in the Arabian Peninsula, highlighting the significance of autochthonous transmission.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
Geographic Location: Arabian Peninsula|Saudi Arabia|Kuwait|Oman|United Arab Emirates
Validation Method: PCR and sequencing

451

Arginine-containing peptides as potent inhibitors of VIM-2 metallo-beta-lactamase.

PMID 26238337 · 2015

The study identifies arginine-containing peptides as potent inhibitors of VIM-2 and IMP-1 metallo-beta-lactamases, highlighting their potential as therapeutic agents against β-lactam-resistant bacteria.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: inhibition
Confers Resistance To: beta lactams
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: enzyme kinetic assays, fluorescence spectroscopy, stopped-flow UV–Vis spectrophotometry

452

Clinical Performance of Check-Direct CPE, a Multiplex PCR for Direct Detection of bla(KPC), bla(NDM) and/or bla(VIM), and bla(OXA)-48 from Perirectal Swabs.

PMID 26338860 · 2015

The study evaluated the clinical performance of Check-Direct CPE for the detection of blaKPC, blaNDM, blaVIM, and blaOXA-48 genes directly from perirectal swabs, demonstrating high sensitivity and negative predictive value for blaKPC.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacter cloacae
• Pseudomonas aeruginosa
Geographic Location: United States
Validation Method: PCR and culture

453

Prevalence and Clonal Dissemination of Metallo-Beta-Lactamase-Producing Pseudomonas aeruginosa in Kermanshah.

PMID 26421137 · 2015

The study identified the VIM gene as a prevalent metallo-beta-lactamase in Pseudomonas aeruginosa isolates from Kermanshah, contributing to carbapenem resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Iran
Validation Method: PCR and DDST

454

Nosocomial emerging of (VIM1) carbapenemase-producing isolates of Klebsiella pneumoniae in North of Iran.

PMID 26622969 · 2015

The study identifies the presence of blaVIM-1 gene in 30% of K. pneumoniae isolates, indicating the emergence of carbapenemase-producing strains in North of Iran.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: North of Iran
Validation Method: PCR and phenotypic testing

455

Evaluation of the BYG Carba Test, a New Electrochemical Assay for Rapid Laboratory Detection of Carbapenemase-Producing Enterobacteriaceae.

PMID 26637378 · 2016

The BYG Carba test was evaluated for the rapid detection of carbapenemase-producing Enterobacteriaceae, demonstrating high sensitivity and specificity for detecting blaOXA-48, blaKPC, blaNDM, and blaVIM genes.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Citrobacter braakii
• Klebsiella pneumoniae
• Providencia vermicola
• Serratia marcescens
• Aeromonas caviae
• Enterobacter cloacae
• Klebsiella oxytoca
Geographic Location: Belgium
Validation Method: electrochemical assay

456

Molecular detection of metallo-β-lactamase genes, bla IMP-1, bla VIM-2 and bla SPM-1 in imipenem resistant Pseudomonas aeruginosa isolated from clinical specimens in teaching hospitals of Ahvaz, Iran.

PMID 26644866 · 2015

The study identified blaIMP-1 and blaVIM-2 genes as the primary contributors to imipenem resistance in Pseudomonas aeruginosa isolates from Ahvaz, Iran.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenem
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Iran
Validation Method: PCR and phenotypic testing

457

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles.

The study characterizes VIM-1, VIM-2, VIM-4, VIM-5, and VIM-38 metallo-beta-lactamase variants, revealing differences in their thermal stability and inhibition profiles, particularly highlighting the superior stability and distinct inhibition characteristics of VIM-5 and VIM-38.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Escherichia coli
Validation Method: recombinant protein production and purification, steady-state kinetic analyses
Sequence Accession: 5A87

458

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Escherichia coli
Validation Method: recombinant protein production and purification, steady-state kinetic analyses
Sequence Accession: 5A87

459

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Escherichia coli
Validation Method: recombinant protein production and purification, steady-state kinetic analyses
Sequence Accession: 5A87

460

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-5
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Escherichia coli
Validation Method: recombinant protein production and purification, steady-state kinetic analyses
Sequence Accession: 5A87

461

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-38
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Escherichia coli
Validation Method: recombinant protein production and purification, steady-state kinetic analyses
Sequence Accession: 5A87

462

β-Lactamase Characterization of Gram-Negative Pathogens Recovered from Patients Enrolled in the Phase 2 Trials for Ceftazidime-Avibactam: Clinical Efficacies Analyzed against Subsets of Molecularly Characterized Isolates.

PMID 26666936 · 2015

The study characterized β-lactamase genes in baseline pathogens from patients enrolled in phase 2 trials for ceftazidime-avibactam, identifying CTX-M-14, CTX-M-15, OXA-1, TEM-1, OXA-1/30, SHV-12, ACC-4, CMY-42, NDM-1, VIM-2, PER-1, and OXA-23 as key resistance determinants against ceftazidime.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: ceftazidime
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: United States|Guatemala|India|Jordan|Lebanon|France|Poland|Romania|Russia
Validation Method: molecular characterization

463

Xpert CARBA-R Assay for the Detection of Carbapenemase-Producing Organisms in Intensive Care Unit Patients of a Korean Tertiary Care Hospital

PMID 26709264 · 2016

The Xpert CARBA-R assay detected carbapenemase-producing organisms (CPO) in ICU patients, identifying blaVIM, blaIMP, and blaKPC genes as responsible for carbapenem resistance.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas monteilii
Geographic Location: Korea
Validation Method: CARBA-R assay

464

Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam-β-Lactamase Inhibitor Combinations.

PMID 26719440 · 2016

The study identifies the coproduction of KPC-18 and VIM-1 carbapenemases in Enterobacter cloacae strain G6809, highlighting the challenge of treating infections caused by multidrug-resistant organisms with newer β-lactam-β-lactamase inhibitor combinations.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Enterobacter cloacae
• Escherichia coli
Geographic Location: Kentucky|United States
Validation Method: whole-genome sequencing and MIC testing
Sequence Accession: KT345945|KT345946|KP681699

465

Triton Hodge Test: Improved Protocol for Modified Hodge Test for Enhanced Detection of NDM and Other Carbapenemase Producers

PMID 26719442 · 2016

The study identifies NDM-1 and VIM-2 as carbapenemase genes that are membrane-anchored, leading to false-negative results in the modified Hodge test (MHT). The addition of Triton X-100 in the MHT (Triton Hodge test) enhances detection of these membrane-bound carbapenemases.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Escherichia coli
Validation Method: phenotypic detection via modified Hodge test and Triton Hodge test

466

Dissemination of carbapenemases producing Gram negative bacteria in the Middle East.

The study reviews the dissemination of carbapenemase-producing Gram-negative bacteria in the Middle East, highlighting the prevalence of KPC, VIM, IMP, NDM, and OXA-48 enzymes in various bacterial species such as Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa.

Gene Information

Gene Name: blaVIM
Allele: blaVIM
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Pseudomonas aeruginosa
• Acinetobacter baumannii
Geographic Location: Middle East|Afghanistan|Iraq|Egypt|Pakistan|Lebanon|Iran|Jordan|Persian Gulf Countries|United Arab Emirates|Kuwait|Qatar|Bahrain|Oman|Saudi Arabia|Turkey
Validation Method: PCR and sequencing

467

Dissemination of carbapenemases producing Gram negative bacteria in the Middle East.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: carbapenemscephalosporinspenicillinaztreonam
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
• Salmonella enterica
• Klebsiella oxytoca
• Enterobacter aerogenes
• Citrobacter freundii
• Proteus mirabilis
• Serratia marcescens
• Enterobacter cloacae
• Acinetobacter spp
• Pseudomonas aeruginosa
• Pseudomonas putida
Geographic Location: Middle East|Afghanistan|Iraq|Egypt|Pakistan|Lebanon|Iran|Jordan|Persian Gulf Countries|United Arab Emirates|Kuwait|Qatar|Bahrain|Oman|Saudi Arabia|Turkey
Validation Method: experimental validation

468

Dissemination of carbapenemases producing Gram negative bacteria in the Middle East.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: carbapenemscephalosporinspenicillinaztreonam
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
• Salmonella enterica
• Klebsiella oxytoca
• Enterobacter aerogenes
• Citrobacter freundii
• Proteus mirabilis
• Serratia marcescens
• Enterobacter cloacae
• Acinetobacter spp
• Pseudomonas aeruginosa
• Pseudomonas putida
Geographic Location: Middle East|Afghanistan|Iraq|Egypt|Pakistan|Lebanon|Iran|Jordan|Persian Gulf Countries|United Arab Emirates|Kuwait|Qatar|Bahrain|Oman|Saudi Arabia|Turkey
Validation Method: experimental validation

469

Dissemination of carbapenemases producing Gram negative bacteria in the Middle East.

Gene Information

Gene Name: blaVIM
Allele: blaVIM-4
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: carbapenemscephalosporinspenicillinaztreonam
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
• Salmonella enterica
• Klebsiella oxytoca
• Enterobacter aerogenes
• Citrobacter freundii
• Proteus mirabilis
• Serratia marcescens
• Enterobacter cloacae
• Acinetobacter spp
• Pseudomonas aeruginosa
• Pseudomonas putida
Geographic Location: Middle East|Afghanistan|Iraq|Egypt|Pakistan|Lebanon|Iran|Jordan|Persian Gulf Countries|United Arab Emirates|Kuwait|Qatar|Bahrain|Oman|Saudi Arabia|Turkey
Validation Method: experimental validation

470

Dissemination of carbapenemases producing Gram negative bacteria in the Middle East.