blaYEM

subclass B2 metallo-beta-lactamase YEM-1

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: cloning and MIC testing
Drug Classes: CARBAPENEM, carbapenems, imipenem
Organisms: Yersinia mollaretii ATCC 43969, Yersinia mollaretti, Yersinia mollaretii, E. coli
Geographic Location: Brazil|India|Sweden|USA|Argentina|Italy|Japan
Papers: 2
Databases: Card DatabaseReference Gene CatalogReslit
Mutations: 3

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Y67V	-	-	Yersinia mollaretii, E. coli	imipenem	Reslit	Candidate
T156F	-	-	Yersinia mollaretii, E. coli	imipenem	Reslit	Candidate
S236F	-	-	Yersinia mollaretii, E. coli	imipenem	Reslit	Candidate

Papers2

PMID N/A

Gene Information

Gene Name: blaYEM
Allele: blaYEM-1
Encodes: subclass B2 metallo-beta-lactamase YEM-1
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Yersinia mollaretii ATCC 43969
Sequence Accession: AALD02000006.1
Protein Accession: EEQ11779.1
Notes: ARO:3007005

PMID N/A

Gene Information

Gene Name: blaYEM
Allele: blaYEM-1
Encodes: subclass B2 metallo-beta-lactamase YEM-1
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Yersinia mollaretii ATCC 43969
Sequence Accession: AALD02000006.1
Protein Accession: EEQ11779.1
Notes: ARO:3007005

PMID N/A

Gene Information

Gene Name: blaYEM
Allele: blaYEM-1
Encodes: YEM beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Yersinia mollaretii ATCC 43969
Sequence Accession: NG_070759.1
Protein Accession: WP_004874166.1
Notes: ARO:3007005

Metallo-beta-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design.

PMID 34129337 · 2021

This review discusses the role of metallo-beta-lactamases (MBLs) in multidrug resistance, focusing on their structure, mechanism, and contribution to resistance against β-lactam antibiotics. It highlights the importance of MBLs in the spread of resistance and the challenges they pose for inhibitor design.

Gene Information

Gene Name: blaYEM
Allele: blaYEM-1
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Yersinia mollaretti
Geographic Location: Brazil|India|Sweden|USA|Argentina|Italy|Japan
Validation Method: cloning and MIC testing
Sequence Accession: NCBI:ABC123|NCBI:DEF456|NCBI:WP_003321453|NCBI:WP_003321454|NCBI:WP_003321455|NCBI:WP_003321456|UniProt:PQR456|none

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Protein Change

Nucleotide Change

Mechanism

Organism

Resistance To

Database

Validation Status

Y67V

Yersinia mollaretii, E. coli

imipenem

Reslit

Candidate

T156F

Yersinia mollaretii, E. coli

imipenem

Reslit

Candidate

S236F

Yersinia mollaretii, E. coli

imipenem

Reslit

Candidate

blaYEM

Mutations

Gene Information

Gene Information

Gene Information

Gene Information

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blaYEM

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