Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
penicillin-hydrolyzing class A beta-lactamase BlaZ
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| BlaZ | Card DatabaseReference Gene CatalogReslit | 369 | BETA-LACTAM, penicillin +18 | Staphylococcus aureus subsp. aureus JH9 +102 | Norway, United States|Thailand|China|Argentina|Chile|Spain|Canada|Belgium|United Kingdom|France|Lebanon, United States, Germany|eastern Saxony|southern Brandenburg, Switzerland|The Netherlands, Taiwan, Switzerland, Germany|United Kingdom|Ireland|France|Malta|Abu Dhabi|Hong Kong|Australia|Trinidad & Tobago|United States|Italy|Spain|Portugal|Switzerland|Canada|Middle East|USA|Asia|UK, Uganda, Spain, Turkey, Tunisia, Finland|Sweden, UK|Germany|Australia|Europe|Asia|Africa, Thailand|Israel, United States|Afghanistan, Japan, Poland, Korea, Belgium, Australia|New Zealand, Sweden, Malaysia|Austria|U.S.A., United Kingdom, Australia, Nsukka agricultural zone, Nigeria, Iran, Italy, Pakistan, Seoul|Cheonan, Germany, Victoria, Australia|Australia, China, Brazil, South Africa, Egypt, India, International Space Station, Malaysia, Nepal, London, UK, Thailand, global, New Zealand, Algeria, Eastern Cape, South Africa, United Kingdom|Colombia, Michigan, USA, Sri Lanka|United Kingdom|Australia, Europe|Asia|North America, Argentina, East London|West London, Europe|Israel|United Kingdom|Republic of Ireland|Italy, Mexico City, Northern Province|Kigali District, Denmark, Russia, Brazil|Santa Catarina|Minas Gerais|Paraná|São Paulo|Rio de Janeiro|Rio Grande do Sul, North West Province, South Africa, Shanghai, Portugal, China|South Korea, Hungary, Vietnam, Sardinia, Italy|Italy, Isfahan, Ghana, Canada|United States, Europe, Europe|Spain|Tunisia|United Kingdom|Denmark|Ireland, U.S., Western Uganda, Portugal|Brazil, Asia|Europe|Americas|China|Taiwan, Iran|Saudi Arabia, Kenya, Northern Xinjiang, China, Hawai'i|Hawaiʻi Island, Manhiça District, Southern Mozambique, Indonesia, Netherlands, Northern Algeria|cattle, Rwanda, Yunnan, China, Novosibirsk, Russia, Southern Thailand, Nigeria|Germany|Singapore|China, Eastern Cape province, South Africa|South Africa, Northern Ghana, Sudan, Saudi Arabia, Bulgaria, Africa|Asia|America|Europe|Oceania|global, Anhui, China, Somalia|Kenya|East Africa, South-eastern Poland, Guangxi, China, Algiers|Algeria, Bangladesh, Silesia, Poland, France, Ningxia Province, Edo, Nigeria, Düzce, Türkiye, Eastern Spain, Global, Guangzhou, China, Finland, Eastern Tanzania, Swiss Canton Tessin|various herds|Switzerland, Benin, Thuringia, Germany, Eastern China, Canada, Rio de Janeiro, Colombia, Guangdong Province, China, North America|South America|Europe|Asia|Africa, Northeast Atlantic Ocean, Shanghai, China, UK|Tunisia|Brazil|Turkey|Algeria|Argentina|Poland|Austria|Germany|Czech Republic|Spain, Slovakia, Spain|Northern Spain, Paraguay, La Rioja, Spain, Vermont, Caatinga biome, Scotland, Western Kenya, Europe|Spain, Brandenburg, Germany, Tanzania, East China, South Korea, Singapore, Nigeria, Canterbury, New Zealand, Europe|Africa|North America|South America|Asia|Oceania, China|Hunan Province, Xizang, Jordan, Denmark|United Kingdom|USA|Netherlands|Mexico, Beira, Mozambique|Mozambique, England, Romania, Egypt|Kuwait, Central Italy, Europe|USA, Japan|Hong Kong, Southeast Nigeria|Nigeria, Central Vietnam, Southern Benin|Benin, Loja, Ecuador, Xinjiang, China, East Africa, Northeast China | 2001, 2002, 2005, 2006, 2007, 2008, 2009, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | CP000704.1 | ABQ50525.1 |
| blaPC1 | Card DatabaseReference Gene CatalogReslit | 6 | BETA-LACTAM, penicillin +1 | Staphylococcus aureus +1 | Canterbury, New Zealand, Europe | 1986, 2024, 2025 | X04121.1 | CAA27733.1 |
| blaZ-like | Reslit | 1 | penicillin | Staphylococcus aureus IMT37556 | Germany | 2021 | - | - |
| blaZ | ResFinder Database | 1 | AMOXICILLIN, AMPICILLIN +2 | Staphylococcus aureus subsp. aureus JH9, Staphylococcus aureus subsp. aureus USA300_TCH1516, Staphylococcus aureus subsp. aureus USA300_TCH959, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus aureus subsp. aureus N315, Staphylococcus xylosus, Bacillus cereus, Staphylococcus aureus M0379, Staphylococcus aureus M0343, Staphylococcus aureus M0996, Staphylococcus aureus DAR3894, Staphylococcus aureus M0515, Staphylococcus aureus T45974, Staphylococcus aureus T54283, Staphylococcus aureus SJUD6098, Staphylococcus aureus DAR5872, Staphylococcus aureus VET1915R, Staphylococcus aureus VET0358R, Staphylococcus aureus MSSA-123, Staphylococcus aureus 56864-11, Staphylococcus aureus Tur-20, Staphylococcus aureus VET0094R, Staphylococcus aureus ZTA11/00189-8HSA, Staphylococcus aureus SA0077, Staphylococcus aureus subsp. aureus CO-98, Staphylococcus aureus subsp. aureus ST772-MRSA-V, Staphylococcus epidermidis FRI909, Staphylococcus argenteus, Staphylococcus aureus subsp. aureus S2395, Paenibacillus polymyxa A18, Streptococcus pneumoniae, Staphylococcus epidermidis, Staphylococcus warneri, Staphylococcus capitis, uncultured bacterium, Staphylococcus aureus M1311, Staphylococcus equorum, Staphylococcus sp. HMSC073C02, Staphylococcus sp. HMSC58E11, Staphylococcus sp. HMSC74G01, Staphylococcus aureus M1044, Staphylococcus aureus M0510, Staphylococcus aureus M0306, Staphylococcus epidermidis NIHLM070, Staphylococcus aureus subsp. aureus CIG1267, Staphylococcus aureus subsp. aureus TW20, Staphylococcus epidermidis BCM-HMP0060, Staphylococcus warneri A487, Staphylococcus aureus subsp. aureus VH60, Staphylococcus aureus M0364, Staphylococcus aureus subsp. aureus 118, Staphylococcus aureus subsp. aureus 11819-97, Staphylococcus epidermidis VCU065, Staphylococcus aureus subsp. aureus CIGC345D, Staphylococcus aureus subsp. aureus DR10, Staphylococcus aureus subsp. aureus 120, Staphylococcus aureus subsp. aureus CN1 | - | 2007 | CP000704, CP000731, CP000732, X04121, AJ302698, AP003139, AP004832, HE993884, DQ269019, FR823292, AJ400722, M15195, KF471116, JBAG01000015, JAZQ01000018, JBTH01000015, JDDF01000008, JBQW01000016, JBMK01000007, JBVX01000014, JGQH01000014, JCHI01000035, JBND01000015, JBLQ01000018, JBKK01000017, JBJP01000007, JDGZ01000043, JDYO01000009, JDXN01000019, JGUQ01000012, JIFU01000008, JINH01000005, JIXQ01000012, JJAO01000008, JIVZ01000012, JITV01000006, JIFD01000012, JEMM01000040, JHTU01000073, AZBT01000050, AENR01000015, CCEE01000006, CAVU010000015, JWJJ01000015, CP010941, CP010944, JYGF01000020, CFPA01000022, CVLS01000543, KR230047, JVWO01000108, JVWM01000127, JUXQ01000001, JVRB01000003, JVLY01000044, JUMU01000089, JURP01000126, JUUA01000057, JVBT01000063, JVML01000111, JVAT01000021, JVOH01000023, JUMX01000103, CSJB01000017, CSEV01000005, CSGM01000014, CTTL01000039, CUHK01000055, CUHB01000033, CUEK01000047, CUGR01000082, CUHG01000035, CYNA01000004, CZWI01000159, LNTF01000008, FFOR01000002, FGNH01000009, KU607301, KU607584, KU607855, FGJZ01000020, FGSJ01000003, FGWO01000019, FHDH01000010, FHDT01000016, AIZE01000023, LRNC01000042, FKTX01000011, FKPS01000007, FKVU01000010, FKQH01000022, FKWG01000001, FKQA01000038, LYRW01000005, MAJJ01000071, LNDI01000019, FMOK01000003, LTEF01000041, LTNH01000008, LTMH01000008, LTLP01000099, MLQA01000023, FQSJ01000009, FQHI01000006, FQJS01000007, FQHX01000011, FQDM01000011, FQPO01000005, AOAS01000022, AJCZ01000013, AJCN01000010, AKGL01000044, AHVS01000008, 13379, FN433596, 13348, ACHE01000004, 4461, CANQ01000029, ALWG01000005, AIWM01000014, AJGE01000057, 13653, 13944, CP003194, 13374, ACFR01000018, GQ900471, AHKZ01000073, GQ900485, AHVO01000010, AIDT01000014, AJGE01000047, AB811795, ALWE01000009, GQ915265, CP003979 | - |
Whole genome sequencing of meticillin-resistant Staphylococcus aureus.
Genome and virulence determinants of high virulence community-acquired MRSA.
Frequency of disinfectant resistance genes and genetic linkage with beta-lactamase transposon Tn552 among clinical staphylococci.
The study identifies the presence of disinfectant resistance genes qacA/B and beta-lactamase gene blaZ in clinical staphylococci, highlighting their genetic linkage with the transposon Tn552. It also reports the presence of the tetracycline resistance gene tetK in these isolates.
Molecular characterization of a widespread, pathogenic, and antibiotic resistance-receptive Enterococcus faecalis lineage and dissemination of its putative pathogenicity island.
The study identifies a widespread, pathogenic, and antibiotic resistance-receptive Enterococcus faecalis lineage, highlighting the presence of the blaZ gene, which confers penicillin resistance, and the dissemination of a putative pathogenicity island.
Characterization of a Strain of Community-Associated Methicillin-Resistant Staphylococcus aureus Widely Disseminated in the United States
The study characterizes a community-associated methicillin-resistant Staphylococcus aureus strain (USA300-0114) that exhibits resistance to multiple antibiotics, including penicillin, oxacillin, erythromycin, tetracycline, and fluoroquinolones. Key resistance genes identified include blaZ, msrA, mecA, tet(K), and ermC, along with the Panton-Valentine leucocidin toxin genes lukF-PV and lukS-PV.
Identification and characterization of bacterial pathogens causing bloodstream infections by DNA microarray.
The study identifies and characterizes bacterial pathogens causing bloodstream infections using a DNA microarray. It highlights the presence of resistance genes such as mecA, blaZ, ermA, aacA-aphD, blaTEM-106, and aacC2, which confer resistance to various antibiotics.
Microarray-based characterisation of a Panton-Valentine leukocidin-positive community-acquired strain of methicillin-resistant Staphylococcus aureus
The study identified the presence of the tetK and far1 genes in a Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus strain, which conferred resistance to tetracycline and fusidic acid respectively. A novel plasmid (pUB102) carrying these genes was also characterized.
Microarray-based characterisation of a Panton-Valentine leukocidin-positive community-acquired strain of methicillin-resistant Staphylococcus aureus.
Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission.
The study identifies new variants of the mecA and mph(C) genes in Staphylococcus species isolated from horses, which confer resistance to beta-lactam and macrolide antibiotics, respectively. Additionally, the aac(6')-Ie-aph(2')-Ia gene was found to confer resistance to gentamicin.
Fusidic acid resistance, mediated by fusB, in bovine coagulase-negative staphylococci.
Isolation and molecular characterization of antibiotic-resistant lactic acid bacteria from poultry and swine meat products.
The study identified tetracycline resistance genes (tet(M)), erythromycin resistance genes (erm(B)), and penicillin resistance gene (blaZ) in lactic acid bacteria isolated from poultry and swine meat products.
Use of a DNA microarray for simultaneous detection of antibiotic resistance genes among staphylococcal clinical isolates.
The study developed a DNA microarray for the simultaneous detection of antibiotic resistance genes in staphylococcal clinical isolates, identifying genes such as mecA, blaZ, aac(6')-Ie-aph(2''), ermA, ermC, and msrA, which confer resistance to methicillin, penicillin, gentamicin, erythromycin, clindamycin, and macrolides/streptogramin B.
Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus.
Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus.
Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus.
Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan.
The study identified a multidrug-resistant PVL+ CA-MRSA ST59 strain in Taiwan with a novel SCC mec type VII, carrying resistance genes such as tetK, cat, aadE, aph(3')-IIIa, ermB, blaZ, and cadDX.
Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.
The study characterizes new SCCmec elements and mutations in topoisomerase genes associated with fluoroquinolone and methicillin resistance in Staphylococcus pseudintermedius.
Inoculum Effect with Cefazolin among Clinical Isolates of Methicillin-Susceptible Staphylococcus aureus: Frequency and Possible Cause of Cefazolin Treatment Failure.
The study identified that 25.5% of MSSA isolates produced type A Bla, 15.3% type B, 45.9% type C, and 13.2% were blaZ negative. Type A Bla producers showed higher cefazolin MICs compared to type B and C producers, indicating a significant inoculum effect associated with cefazolin treatment failure.
Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era.
The study highlights the emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and characterizes the genetic elements, such as blaZ and mecA, that confer resistance. It discusses the role of genomic sequencing in understanding the evolution and virulence of CA-MRSA.
Massively parallel pathogen identification using high-density microarrays.
The study demonstrates the use of a high-density microarray for the identification of pathogens and the detection of antibiotic resistance genes, including blaZ, ermC, mph, and tetK, in clinical samples.
A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus.
The study characterizes various methicillin-resistant Staphylococcus aureus (MRSA) clones, highlighting their antimicrobial resistance and virulence-associated markers, with a focus on SCC mec types and PVL status.
Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus.
Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus.
High prevalence of methicillin resistant Staphylococcus aureus in the surgical units of Mulago hospital in Kampala, Uganda.
The study identified a high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in the surgical units of Mulago hospital in Kampala, Uganda. It also characterized several AMR genes including mecA, blaZ, and aminoglycoside-modifying enzymes such as aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, and ant(4')-Ia.
Genotypes, exotoxin gene content, and antimicrobial resistance of Staphylococcus aureus strains recovered from foods and food handlers.
The study identified various AMR genes in S. aureus strains from foods and food handlers, including blaZ, mupA, ermC, msrB, msrA, aacA, aphD, aadD, and tetK, which confer resistance to beta-lactams, mupirocin, erythromycin, clindamycin, aminoglycosides, and tetracycline.
Antibiotic resistance genes & susceptibility patterns in staphylococci.
The study identified several antibiotic resistance genes in staphylococcal isolates, including mecA for methicillin resistance, aac(6')/aph(2"), aph(3')-IIIa, and ant(4')-Ia for gentamicin resistance, ermA, ermB, ermC, and msrA for erythromycin resistance, tetK and tetM for tetracycline resistance, and blaZ for penicillin resistance.
High diversity of genetic lineages and virulence genes in nasal Staphylococcus aureus isolates from donkeys destined to food consumption in Tunisia with predominance of the ruminant associated CC133 lineage.
The study identified various AMR genes in nasal Staphylococcus aureus isolates from donkeys, including blaZ, erm(A), erm(C), tet(M), and fusC, which confer resistance to penicillin, erythromycin, tetracycline, and fusidic acid.
Genetic basis of penicillin resistance of S. aureus isolated in bovine mastitis.
The study identified the blaZ gene as responsible for penicillin resistance in S. aureus isolates from bovine mastitis. The gene was found on plasmids in a significant portion of the isolates, but its location did not explain the higher prevalence of resistance in Finland compared to Sweden.
A Staphylococcus xylosus isolate with a new mecC allotype.
A novel approach to associate genes and mutations with drug resistance phenotypes by comparative analysis of fully sequenced bacterial strains
The study identified several AMR genes and mutations associated with drug resistance in S. aureus, including blaZ, mecA, tet, tetM, aacA-aphD, and mutations in rpsL, rpsJ, grlA, and gyrA.
A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic.
The study identifies key AMR genes and mutations in the EMRSA-15 pandemic clone, including blaZ, ermC, mecA, and mutations in grlA and gyrA that confer fluoroquinolone resistance.
Novel pseudo-staphylococcal cassette chromosome mec element (ψSCCmec57395) in methicillin-resistant Staphylococcus pseudintermedius CC45.
The study identifies a novel pseudo-staphylococcal cassette chromosome mec element (ψSCCmec57395) in methicillin-resistant Staphylococcus pseudintermedius CC45, along with various AMR genes such as mecA, blaZ, aac(6')-Ie–aph(2')-Ia, aph(3')-III, ant(6)-Ia, sat4, erm(B), tet(M), dfr(G), and cat pC221. Additionally, fluoroquinolone resistance was linked to specific mutations in gyrA and grlA.
Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics.
The study identifies mecA and blaZ as genes responsible for methicillin resistance in MRSA, demonstrating their role in conferring resistance to beta-lactam antibiotics.
Staphylococcus aureus colonization of healthy military service members in the United States and Afghanistan.
The study identified several AMR genes in MRSA and MSSA isolates, including ermC, tetK, tetM, blaZ, msrA, and ermA, which confer resistance to clindamycin, tetracycline, penicillin, and erythromycin. These findings highlight the genetic basis of antimicrobial resistance in S. aureus isolates from military personnel in the US and Afghanistan.
Emergence of Staphylococcus aureus carrying multiple drug resistance genes on a plasmid encoding exfoliative toxin B.
The study identifies the presence of multiple drug resistance genes on a plasmid encoding exfoliative toxin B in Staphylococcus aureus, including aac(6')-aph(2"), msrA, and blaZ, which confer resistance to gentamicin, kanamycin, tobramycin, erythromycin, and penicillin.
Antibiotic resistance in Staphylococcus aureus strains isolated from cows with mastitis in eastern Poland and analysis of susceptibility of resistant strains to alternative nonantibiotic agents: lysostaphin, nisin and polymyxin B.
The study identified the blaZ gene, which encodes a beta-lactamase, as a determinant of resistance to penicillin, ampicillin, and amoxicillin in Staphylococcus aureus isolates from bovine mastitis in eastern Poland.
Development and Testing of a Genotypic Prediction Method for Antimicrobial Susceptibility from Whole-Genome Sequencing
Effect of ampicillin, streptomycin, penicillin and tetracycline on metal resistant and non-resistant Staphylococcus aureus.
The study found that lead-resistant S. aureus (RPb) showed resistance to ampicillin and streptomycin, while cadmium-resistant S. aureus (RCd) did not show resistance to these antibiotics. The zntA and zntR genes were involved in heavy metal resistance mechanisms.
Antibiotic resistance and molecular characterization of ophthalmic Staphylococcus pseudintermedius isolates from dogs.
The study identified the blaZ and mecA genes in ophthalmic Staphylococcus pseudintermedius isolates from dogs, with blaZ conferring resistance to penicillin and mecA conferring resistance to oxacillin and penicillin.
Rapid optical determination of beta-lactamase and antibiotic activity.
The study introduces a rapid optical method called β-LEAF to detect beta-lactamase production and assess the activity of β-lactam antibiotics, demonstrating its consistency with traditional methods.
Development of oxacillin resistance in a patient with recurrent Staphylococcus aureus bacteremia.
The study identifies a novel 5-bp TATCC frameshift insertion in an ABC transporter gene and a 3-bp GCT nonframeshift insertion in the pdhA gene as potential mechanisms for oxacillin resistance in Staphylococcus aureus isolates lacking the mecA gene.
Epidemiology and molecular characterization of methicillin-resistant Staphylococcus aureus nasal carriage isolates from bovines.
The study identified multiple AMR genes in MRSA isolates from bovines, including blaZ, blaI, blaR, tetM, ermC, aacA-aphD, aadD, aphA3, cat, sdrM, and fosB, which confer resistance to penicillin, tetracycline, erythromycin, gentamicin, kanamycin, chloramphenicol, and fosfomycin.
Genetic and molecular predictors of high vancomycin MIC in Staphylococcus aureus bacteremia isolates.
The study identified several genes associated with elevated vancomycin MIC in Staphylococcus aureus bacteremia isolates, including blaZ, sea, clfA, splA, and the ACME locus. These genes were found to be linked to higher vancomycin MICs and were associated with specific clonal complexes and virulence factors.
Long term molecular epidemiology of methicillin-susceptible Staphylococcus aureus bacteremia isolates in Sweden.
The study identified the blaZ gene, which encodes penicillinase, as the only antibiotic resistance gene commonly found in methicillin-susceptible Staphylococcus aureus (MSSA) isolates. Other antibiotic resistance genes were sporadically detected and the overall prevalence of resistance genes did not increase during the study period.
Detection of antibiotic resistance in probiotics of dietary supplements.
The study detected antibiotic resistance in probiotic bacteria from dietary supplements, including resistance to streptomycin, gentamycin, aztreonam, and ciprofloxacin. Intrinsic resistance genes such as aac(6')-aph(2"), ant(6), aph(3')-IIIa, and blaZ were identified as potential contributors to the observed resistance profiles.
Old Drugs To Treat Resistant Bugs: Methicillin-Resistant Staphylococcus aureus Isolates with mecC Are Susceptible to a Combination of Penicillin and Clavulanic Acid.
The study demonstrates that mecC-encoded PBP2c does not mediate resistance to penicillin, and the adjacent blaZ gene is required for penicillin resistance. The combination of penicillin and clavulanic acid effectively treats mecC-MRSA infections in vitro and in a wax moth larva model.
Comparative genomics of non-pseudomonal bacterial species colonising paediatric cystic fibrosis patients.
The study analyzed non-pseudomonal bacterial species from pediatric cystic fibrosis patients, identifying several AMR genes and mutations. Key findings include the presence of beta-lactamase genes (blaZ, blaI, blaRI) in Staphylococcus aureus, fosfomycin resistance gene fosB, fusidic acid resistance gene fusC, and efflux pumps smeZ, smeJ, and smeK in Stenotrophomonas maltophilia. Additionally, Enterobacter cloacae isolates carried resistance genes qacE delta 1, sul1, and dfrA5.
Characterization of mannitol-fermenting methicillin-resistant staphylococci isolated from pigs in Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant staphylococci isolated from pigs in Nigeria, including mecA, blaZ, erm(C), erm(B), str, tet(K), tet(M), tet(L), dfrG, dfrK, aacA/aphD, aphA3, cat pC221, and cat pC223. Additionally, a Ser84Leu mutation in the gyrA gene was found to confer ciprofloxacin resistance.
Nasal Carriage of Staphylococcus aureus : Frequency and Antibiotic Resistance in Healthy Ruminants.
The study identified the presence of antibiotic resistance genes blaZ, mecA, tetK, and tetM in Staphylococcus aureus isolates from healthy ruminants, highlighting the potential reservoir of antimicrobial-resistant S. aureus in nasal carriage.
A Livestock-Associated, Multidrug-Resistant, Methicillin-Resistant Staphylococcus aureus Clonal Complex 97 Lineage Spreading in Dairy Cattle and Pigs in Italy.
The study identifies multiple AMR genes in CC97 MRSA isolates from Italian dairy cattle and pigs, including erm(B), erm(C), vga(A), tet(K), tet(M), blaZ, and aacA-aphD, which confer resistance to various antibiotics such as erythromycin, clindamycin, tiamulin, tetracycline, penicillin, and aminoglycosides.
Molecular detection of antimicrobial resistance in local isolates of Staphylococcus epidermidis from urinary tract infections in Faisalabad region of Pakistan.
The study identified multiple antimicrobial resistance genes in Staphylococcus epidermidis isolates from urinary tract infections in Pakistan, including tetM, tetK, aac(6')/aph(2"), aacA-aphD, ermA, blaZ, mecA, MeccA, and blaTEM-1, indicating widespread multidrug resistance.
Antimicrobial susceptibility and pathogenic genes of Staphylococcus aureus isolated from the oral cavity of patients with periodontitis.
The study identified the blaZ, aph(3')-IIIa, and tem genes as responsible for penicillin, gentamicin, and ampicillin resistance in Staphylococcus aureus isolates from periodontitis patients.
A Look into the Melting Pot: The mecC-Harboring Region Is a Recombination Hot Spot in Staphylococcus stepanovicii.
The study identifies the mecC gene in Staphylococcus stepanovicii strain IMT28705, which confers methicillin resistance. Additionally, the blaZ gene, encoding a beta-lactamase, was found in the same genomic region.
Proteomic response of methicillin-resistant S. aureus to a synergistic antibacterial drug combination: a novel erythromycin derivative and oxacillin.
The study identifies the downregulation of mecA and blaZ genes in MRSA under the synergistic effect of SIPI-8294 and oxacillin, suggesting interference with oxacillin resistance mechanisms.
Complete genome of Staphylococcus aureus Tager 104 provides evidence of its relation to modern systemic hospital-acquired strains.
The study characterizes the complete genome of Staphylococcus aureus Tager 104, identifying the blaZ gene as a beta-lactamase that confers resistance to penicillins and cephalosporins.
Characterization of Staphylococcus aureus isolates from raw milk sources in Victoria, Australia.
Only one isolate was resistant to penicillin, carrying the blaZ gene, while no resistance to other antibiotics was found.
Comparative virulence studies and transcriptome analysis of Staphylococcus aureus strains isolated from animals.
The study identified the ermC gene, which confers resistance to macrolides, lincosamides, and streptogramin B, and SAAV_1916, a multidrug ABC transporter, which is associated with resistance in the highly virulent MRSA1679a strain.
Correlation of phenotypic tests with the presence of the blaZ gene for detection of beta-lactamase.
The study found that the blaZ gene is strongly correlated with penicillin resistance in Staphylococcus spp., particularly in S. saprophyticus. The zone edge test was the most sensitive phenotypic method for detecting beta-lactamase production.
Biofilm production and beta-lactamic resistance in Brazilian Staphylococcus aureus isolates from bovine mastitis.
The study identified blaZ and mecA genes associated with beta-lactamic resistance in Staphylococcus aureus isolates from bovine mastitis, with blaZ linked to penicillin resistance and mecA to oxacillin and cefoxitin resistance.
Characterization of Methicillin-Resistant Staphylococcus aureus Isolated from Healthy Turkeys and Broilers Using DNA Microarrays.
The study identified several AMR genes in MRSA isolates from healthy turkeys and broilers, including ermA, ermB, ermC, tetK, tetM, lnuA, mphC, vgaA, aadD, aphA3, blaZ, blaI, blaR, and mecA. These genes conferred resistance to various antibiotics such as erythromycin, clindamycin, tetracycline, lincomycin, macrolides, streptogramins, tobramycin, neomycin, kanamycin, and beta-lactam antibiotics.
Antibiotic resistance potential of the healthy preterm infant gut microbiome.
The study identified 39 distinct AMR genes across eight antibiotic classes in the gut microbiome of eleven preterm infants, including the beta-lactamase gene blaZ and the methicillin resistance gene mecA.
Genetic characterisation of antimicrobial resistance and virulence genes in Staphylococcus aureus isolated from commercial broiler chickens in the Durban metropolitan area, South Africa.
The study identified the presence of antimicrobial resistance genes mecA, BlaZ, and tetK in Staphylococcus aureus isolates from broiler chickens, indicating resistance to methicillin, penicillin, and tetracycline, respectively.
Transmission of highly virulent community-associated MRSA ST93 and livestock-associated MRSA ST398 between humans and pigs in Australia.
The study identified the presence of CA-MRSA ST93-IV and LA-MRSA ST398-V in Australian pigs, farm workers, and the environment. It also reported the first linezolid-resistant MRSA isolate in Australia. Resistance mechanisms included genes such as blaZ, ermC, fexA, tetK, tetL, vgaA, lnuB, aadD, aadE, and cfr.
Genetic Characterization, Antimicrobial Resistance Patterns and Virulence Determinants of Staphylococcus aureus Isolated form Bovine Mastitis.
The study identified blaZ and mecA genes in Staphylococcus aureus isolates from bovine mastitis, indicating resistance to penicillin and methicillin/oxacillin, respectively.
Genotypic and phenotypic β-lactam resistance and presence of PVL gene in Staphylococci from dry bovine udder.
The study identified blaZ and mecA genes responsible for β-lactam resistance in Staphylococci from dry bovine udders, along with the PVL gene associated with virulence.
Genomic comparison between Staphylococcus aureus GN strains clinically isolated from a familial infection case: IS1272 transposition through a novel inverted repeat-replacing mechanism.
The study identifies the presence of penicillin resistance genes blaZ, blaR1, and blaI in Staphylococcus aureus GN strains, highlighting their role in penicillin resistance.
Polymerase chain reaction detection of genes responsible for multiple antibiotic resistance Staphylococcus aureus isolated from food of animal origin in Egypt.
The study identified several antibiotic resistance genes in multiple drug-resistant Staphylococcus aureus isolates from food of animal origin in Egypt, including blaZ, tetK, ermB, msrA, ermC, and aac(6')-aph(2").
Prevalence of blaZ Gene and Performance of Phenotypic Tests to Detect Penicillinase in Staphylococcus aureus Isolates from Japan.
The study identified two blaZ-positive Staphylococcus aureus isolates and evaluated the performance of various phenotypic tests for detecting penicillinase, highlighting their low sensitivity and positive predictive value due to the low prevalence of blaZ in Japanese isolates.
Detection of antimicrobial resistance genes associated with the International Space Station environmental surfaces.
The study identified multiple antimicrobial resistance (AMR) genes associated with the International Space Station (ISS) environmental surfaces, highlighting the presence of resistance mechanisms against various antibiotics, including beta-lactams, fluoroquinolones, and tetracyclines. Notably, genes such as mecA, blaZ, and qacB were detected, indicating resistance to methicillin, penicillin, and quaternary ammonium compounds, respectively.
Characterization of resistance to selected antibiotics and Panton-Valentine leukocidin-positive Staphylococcus aureus in a healthy student population at a Malaysian University.
The study identified blaZ, msrA, and ermC genes as responsible for penicillin and erythromycin resistance in Staphylococcus aureus isolates from healthy students in Malaysia.
The human clone ST22 SCCmec IV methicillin-resistant Staphylococcus aureus isolated from swine herds and wild primates in Nepal: is man the common source?
The study identified AMR genes erm(C), aacC-aphD, and blaZ in MRSA isolates from swine and primates, along with a chromosomal mutation gyrA Ser84Leu associated with ciprofloxacin resistance.
Whole Genome Sequence and Comparative Genomics Analysis of Multi-drug Resistant Environmental Staphylococcus epidermidis ST59.
The study identifies several antibiotic resistance genes in the multidrug-resistant S. epidermidis strain G6_2, including aac(6')-aph(2"), blaZ, mecA, fosB, mphC, msrA, tetK, and qacC, which confer resistance to various antibiotics. Additionally, point mutations in ileS and fusA are associated with resistance to mupirocin and fusidic acid.
Staphylococcus argenteus from rabbits in Thailand.
The study identified three S. argenteus isolates from rabbits in Thailand, with one isolate showing susceptibility to all tested antimicrobials and two showing resistance to penicillin and doxycycline. The S. argenteus isolates carried the blaZ gene, while S. aureus isolates carried additional resistance genes such as mecA, aacA-aphD, and mrs(A). Mutations in gyrA and grlA were found in an S. aureus isolate, indicating potential fluoroquinolone resistance.
Antimicrobial Resistance in Staphylococci of Animal Origin
The paper discusses various antimicrobial resistance genes and mutations in staphylococci of animal origin, highlighting their roles in resistance to multiple antibiotics such as macrolides, lincosamides, streptogramins, oxazolidinones, and others. Key genes include erm, msr, mph, ere, lnu, vga, cfr, optrA, dfr, fus, ileS2, blaZ, aadD, ble, fosD, fosB, czrC, and qac genes, which confer resistance to specific antibiotics and are prevalent in different staphylococcal species.
Genomic Analysis of Multiresistant Staphylococcus capitis Associated with Neonatal Sepsis.
The study identifies several AMR genes in multidrug-resistant Staphylococcus capitis isolates associated with neonatal sepsis, including blaZ, fusB, aadD, qacA, and aac(6')-aph(2'). These genes confer resistance to amoxicillin, fusidic acid, aminoglycosides, chlorhexidine, and gentamicin, respectively.
Emerging of antimicrobial resistance in staphylococci isolated from clinical and food samples in Algeria.
The study identified several AMR genes in staphylococci from clinical and food samples in Algeria, including blaZ, mecA, tetM, tetK, aacA-aphD, and ermC. These genes conferred resistance to penicillin, methicillin, tetracycline, gentamicin, and erythromycin.
Occurrence and characterization of methicillin-resistant Staphylococcus pseudintermedius in successive parturitions of bitches and their puppies in two kennels in Italy.
The study identified multiple methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains in two Italian kennels, highlighting the presence of various resistance mechanisms including beta-lactam, aminoglycoside, macrolide, tetracycline, and chloramphenicol resistance genes.
Antimicrobial Resistance Profiles of Staphylococcus aureus Isolated from Meat Carcasses and Bovine Milk in Abattoirs and Dairy Farms of the Eastern Cape, South Africa.
The study identified blaZ and msrA as significant antimicrobial resistance genes in Staphylococcus aureus isolates from meat and milk samples in the Eastern Cape, South Africa.
Transcriptome analysis of extended-spectrum beta-lactamase-producing Escherichia coli and methicillin-resistant Staphylococcus aureus exposed to cefotaxime.
The study identifies and characterizes the beta-lactamase genes bla CTX-M-15, bla CMY-2, mecA, and blaZ as the primary mechanisms of cefotaxime resistance in the studied strains of Escherichia coli and Staphylococcus aureus.
Death Associated to Methicillin Resistant Staphylococcus aureus ST8 Infection in Two Dolphins Maintained Under Human Care, Italy.
The study reports the isolation of Methicillin-resistant Staphylococcus aureus (MRSA) from two dolphins, identifying the presence of the methicillin-resistance gene mecA, penicillase genes blaZ, blaI, and blaR, as well as genes for macrolide resistance (ermC) and aminoglycoside resistance (aadD).
Severe Disseminated Infection with Emerging Lineage of Methicillin-Sensitive Staphylococcus aureus
The study reports a case of severe disseminated infection caused by methicillin-sensitive Staphylococcus aureus (MSSA) clonal complex 398, which exhibited resistance to penicillin, erythromycin, and clindamycin due to the presence of the blaZ and erm(T) genes.
Nasal Resistome Development in Infants With Cystic Fibrosis in the First Year of Life.
The study identified various antimicrobial resistance genes in the nasal microbiome of infants with cystic fibrosis, including beta-lactamases, chloramphenicol efflux pumps, tetracycline resistance proteins, and enzymes involved in folic acid synthesis inhibition.
Detection of critical antibiotic resistance genes through routine microbiome surveillance.
The study identifies various antibiotic resistance genes (ARGs) associated with multidrug resistance, including macrolide, beta-lactam, tetracycline, and methicillin resistance genes, highlighting the presence of these genes in postmortem microbiome samples.
Genomic and Epidemiological Evidence of a Dominant Panton-Valentine Leucocidin-Positive Methicillin Resistant Staphylococcus aureus Lineage in Sri Lanka and Presence Among Isolates From the United Kingdom and Australia.
The study identified a dominant PVL-positive ST5-MRSA-IVc clone in Sri Lanka, which was also found in the UK and Australia. The clone exhibited resistance to methicillin, erythromycin, tetracycline, gentamicin, and streptothricin.
Staphylococcus aureus in Animals.
The paper discusses the role of Staphylococcus aureus in various animal hosts, highlighting the presence of antimicrobial resistance genes such as blaZ, mecA, mecC, tetracycline resistance genes, and chloramphenicol resistance genes. It emphasizes the significance of mobile genetic elements in the adaptation and spread of these resistance determinants among different host species.
Staphylococcus lugdunensis: antimicrobial susceptibility and optimal treatment options.
The study found that Staphylococcus lugdunensis isolates were mostly susceptible to antibiotics, with 74.6% susceptible to penicillin G. Two isolates carrying the mecA gene were found to harbor the SCC mec type IVa(2B), and the blaZ gene was identified in one isolate, contributing to penicillin resistance.
Inoculum effect of β-lactam antibiotics.
The study reviews the inoculum effect of β-lactam antibiotics against various bacterial pathogens, highlighting that beta-lactamase enzymes are the primary mechanism responsible for the inoculum effect, although other mechanisms may also contribute.
Occurrence and Characteristics of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Quarter Milk Samples From Dairy Cows in Germany.
This study identified 10 LA-MRSA isolates from dairy cows in Germany, all belonging to clonal complex CC398. These isolates exhibited resistance to methicillin, tetracycline, and macrolides/lincosamides, with the presence of mecA, blaZ, tet(K), tet(M), erm(A), and spc genes.
Antimicrobial Resistance Patterns in Methicillin-Resistant Staphylococcus aureus from Patients Hospitalized during 2015-2017 in Hospitals in Poland.
The study identified high levels of multidrug resistance in MRSA isolates, with resistance to fluoroquinolones, macrolides, and lincosamides being prevalent. The blaZ and mecA genes were detected in all isolates, contributing to resistance against penicillin and methicillin, respectively.
Detection of Antibiotic Resistance and Classical Enterotoxin Genes in Coagulase-negative Staphylococci Isolated from Poultry in Poland.
The study identified several AMR genes in coagulase-negative Staphylococcus (CNS) isolates from poultry in Poland, including blaZ, mecA, tetK, tetL, ermA, ermB, aac(6')-Ie-aph(2'')-Ia, msrA/B, and cfr. These genes conferred resistance to various antibiotics such as beta-lactams, methicillin, tetracyclines, macrolides, lincosamides, streptogramin B, aminoglycosides, phenicols, oxazolidinones, pleuromutilins, and streptogramin A.
Phylogenetic and Molecular Profile of Staphylococcus aureus Isolated from Bloodstream Infections in Northeast Brazil.
The study identified high resistance to oxacillin, clindamycin, erythromycin, ciprofloxacin, and gentamicin among S. aureus isolates. The mecA and blaZ genes were detected, contributing to beta-lactam resistance. New sequence types (STs) were classified, indicating clonal diversity.
Identification and molecular epidemiology of methicillin resistant Staphylococcus pseudintermedius strains isolated from canine clinical samples in Argentina.
The study identified various AMR genes in methicillin-resistant Staphylococcus pseudintermedius (MRSP) isolates from Argentina, including mecA, blaZ, ermB, dfrG, aph(3')-III, ant(6)-Ia, tetM, and aac(6')-Ie-aph(2')-Ia. Mutations in gyrA (S84L) and grlA (S80I) were associated with ciprofloxacin resistance.
Whole genome sequencing revealed new molecular characteristics in multidrug resistant staphylococci recovered from high frequency touched surfaces in London.
The study identified several AMR genes in multidrug-resistant staphylococci from high-frequency touched surfaces in London, including blaZ, qacA/B, dfrC, norA, ant(4')-Ib, AAC(6')-Ie-APH(2")-Ia, fusB, msrA, ermC, mphC, tetK, mupA, cat, dfrG, lnuA, fusC, aph3-IIIa, sat4A, vgaA, and others. These genes conferred resistance to various antibiotics such as penicillin, fusidic acid, mupirocin, tetracycline, erythromycin, and chloramphenicol.
Molecular Characterization of Equine Staphylococcus aureus Isolates Exhibiting Reduced Oxacillin Susceptibility.
The study identifies several AMR genes and mutations associated with reduced oxacillin susceptibility in equine Staphylococcus aureus isolates, including blaZ, aadD, dfrG, tet(L), and aacA-aphD, along with various mutations in genes such as FemA, FemB, FemX, CcpA, GdpP, and PBP1-4.
Comparative Genomic Analysis of Staphylococcus haemolyticus Reveals Key to Hospital Adaptation and Pathogenicity.
The study identifies several AMR genes and mutations associated with hospital adaptation and pathogenicity in Staphylococcus haemolyticus, highlighting the importance of mecA, aacA-aphD, blaZ, ermC, mphC, qacA, qacB, folP, folB, and sraP in clinical isolates.
Evolution of Antibiotic Resistance of Coagulase-Negative Staphylococci Isolated from Healthy Turkeys in Egypt: First Report of Linezolid Resistance.
This study identified the first report of linezolid resistance in coagulase-negative staphylococci (CoNS) isolated from healthy turkeys in Egypt. The study found that 79.5% of the isolates were resistant to linezolid, and the resistance was associated with the presence of the cfr, optrA, and valS genes. The study also found high levels of resistance to other antibiotics, including erythromycin, chloramphenicol, oxacillin, daptomycin, and tigecycline.
Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure.
The study identifies silenced antibiotic resistance genes in Staphylococcus aureus, highlighting the prevalence of transient antibiotic resistance due to mutations that inactivate resistance genes, leading to apparent susceptibility but potential re-emergence of resistance.
Antimicrobial Resistance, Virulence, and Genetic Lineages of Staphylococci from Horses Destined for Human Consumption: High Detection of S. aureus Isolates of Lineage ST1640 and Those Carrying the lukPQ Gene.
The study identified antimicrobial resistance genes such as ant(6)-Ia, blaZ, dfrA, and dfrG in Staphylococcus aureus isolates, along with the equine-adapted leukocidin gene lukPQ and the complement inhibitor gene scn-eq. These findings highlight the presence of virulence and resistance determinants in S. aureus isolates from horses.
Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children's Hospital in México City in an eight-years survey.
The study identifies various AMR genes and mutations in multidrug-resistant Staphylococcus epidermidis strains isolated from a children's hospital in Mexico City, highlighting the presence of genes such as blaZ, mecA, and others, as well as mutations in gyrA and rpoB contributing to resistance.
Synergistic Antibacterial Activity of Designed Trp-Containing Antibacterial Peptides in Combination With Antibiotics Against Multidrug-Resistant Staphylococcus epidermidis.
The study identified that Trp-containing peptides synergistically enhance the antibacterial activity of antibiotics against multidrug-resistant Staphylococcus epidermidis by reducing the expression of resistance genes such as bla Z, tet(m), and msr A.
Characterization of Antibiotic and Biocide Resistance Genes and Virulence Factors of Staphylococcus Species Associated with Bovine Mastitis in Rwanda.
The study identified several antibiotic and biocide resistance genes in Staphylococcus species associated with bovine mastitis in Rwanda, including blaZ, tet(K), erm(C), vga(A), sal(A), lnu(A), msr(A), dfrA, dfrD, dfrG, smr, qacAB, cadD, copB, and arsA. These genes conferred resistance to various antibiotics such as penicillin, tetracycline, erythromycin, clindamycin, trimethoprim, and biocides like quaternary ammonium compounds.
Antimicrobial Resistance and Virulence Gene Profiles of Methicillin-Resistant and -Susceptible Staphylococcus aureus From Food Products in Denmark.
The study identified several antimicrobial resistance genes, including blaZ, tet(K), tet(L), tet(M), and various erm genes, in Staphylococcus aureus isolates from food products in Denmark. Additionally, the tst gene was detected in CC398 and CC45 isolates, indicating the presence of toxic shock syndrome toxin.
Characterization of the First mecA-Positive Multidrug-Resistant Staphylococcus pseudintermedius Isolated from an Argentinian Patient.
The study characterizes the first mecA-positive multidrug-resistant Staphylococcus pseudintermedius isolate from an Argentinean patient, identifying several AMR genes and mutations associated with resistance to multiple antibiotics.
Genotypic and Phenotypic-Based Assessment of Antibiotic Resistance and Profile of Staphylococcal Cassette Chromosome mec in the Methicillin-Resistant Staphylococcus aureus Recovered from Raw Milk.
The study identified several AMR genes in MRSA isolates from raw milk, including blaZ, tetK, dfrA1, aacA-D, ermA, and gyrA, which confer resistance to various antibiotics such as penicillin, tetracycline, trimethoprim-sulfamethoxazole, gentamicin, erythromycin, and fluoroquinolones.
Whole-Genome Sequencing of Lactobacillus helveticus D75 and D76 Confirms Safety and Probiotic Potential.
The study identified eight genes associated with moderate antibiotic resistance and resistance against xenobiotics in Lactobacillus helveticus D75 and D76, including blaZ, pbpX, mprF, and had.
Milk microbial composition of Brazilian dairy cows entering the dry period and genomic comparison between Staphylococcus aureus strains susceptible to the bacteriophage vB_SauM-UFV_DC4.
The study identified the presence of the beta-lactamase gene blaZ in Staphylococcus aureus strains, which conferred resistance to ampicillin. The MIC assay showed higher resistance levels in the strains compared to the resistance breakpoints.
Antimicrobial Resistance in Farm Animals in Brazil: An Update Overview.
The review highlights the prevalence of antimicrobial resistance in farm animals in Brazil, particularly in Salmonella, E. coli, and Campylobacter. Key resistance genes identified include blaCTX-M-2 and blaTEM-1, which confer resistance to beta-lactam antibiotics.
Genotypic and Phenotypic Evaluation of Biofilm Production and Antimicrobial Resistance in Staphylococcus aureus Isolated from Milk, North West Province, South Africa.
The study identified several antimicrobial resistance genes, including blaZ, vanB, tetK, tetL, and msrA/B, in Staphylococcus aureus isolates from milk. These genes were associated with resistance to penicillin, vancomycin, tetracycline, and macrolides. Additionally, biofilm-forming genes icaA, icaB, icaC, icaD, and bap were detected, highlighting the potential public health risk posed by these isolates.
Antimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus Causing Bloodstream Infections at Ruijin Hospital in Shanghai from 2013 to 2018.
The study identified blaZ as a gene conferring resistance to penicillin in Staphylococcus aureus isolates. No resistance to vancomycin, daptomycin, synercid, linezolid, or ceftaroline was found. MRSA isolates showed high resistance to penicillin and other antibiotics.
Virulence Factors and Phylogeny of Staphylococcus aureus Associated With Bovine Mastitis in Russia Based on Genome Sequences.
The study identified antibiotic resistance genes blaZ, ermC, aac(3), aph(2), and norA in Staphylococcus aureus isolates associated with bovine mastitis in Russia. These genes conferred resistance to penicillin, erythromycin, and gentamicin.
Characterization of Staphylococci and Streptococci Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified multiple AMR genes in Staphylococcus and Streptococcus isolates from bovine milk, including blaZ, mecA, erm(C), aac(aph)D, tetK, tetL, tetM, lnuA, erm(A), erm(B), aphA-3, aad-6, and optrA, indicating widespread resistance to beta-lactams, macrolides, aminoglycosides, tetracyclines, and linezolid.
Phenotypic and Genotypic Assessment of Antibiotic Resistance of Staphylococcus aureus Bacteria Isolated from Retail Meat.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from retail meat, including blaZ, tetK, aacA-D, and ermA, which confer resistance to penicillin, tetracycline, gentamicin, and macrolides/lincosamides/streptogramin B, respectively.
Profiles of Staphyloccocus aureus isolated from goat persistent mastitis before and after treatment with enrofloxacin.
The study identified several AMR genes in Staphylococcus aureus isolates from goat mastitis, including blaZ, ermA, ermB, mecA, tetK, tetM, norA, norC, and lmrS. These genes conferred resistance to various antibiotics such as penicillin, erythromycin, methicillin, tetracycline, and fluoroquinolones.
Prevalence and distribution of antimicrobial resistance determinants of Escherichia coli isolates obtained from meat in South Africa.
The study identified several AMR genes in E. coli isolates from meat in South Africa, including aadA, strA, aph(3)-Ia, aph(3)-IIa, aac(3)-IIa, blaTEM, blaZ, ampC, cat1, cat2, cmlA1, sul1, sul2, tetA, tetB, tetC, tetD, and tetM, which confer resistance to various antibiotics such as streptomycin, kanamycin, neomycin, gentamicin, amoxicillin, ampicillin, chloramphenicol, cotrimoxazole, and tetracycline.
Simultaneous Nasal Carriage by Methicillin-Resistant and Methicillin Susceptible Staphylococcus aureus of Lineage ST398 in a Live Pig Transporter.
The study characterizes two S. aureus ST398 strains, one methicillin-resistant (MRSA) and one methicillin-susceptible (MSSA), isolated from a pig transporter. The MRSA strain harbors the mecA gene, while the MSSA strain lacks it due to a large deletion. Both strains exhibit resistance to several antibiotics including tetracycline, lincosamides, aminoglycosides, and trimethoprim.
Complete genome sequence of a methicillin-resistant Staphylococcus lugdunensis strain and characteristics of its staphylococcal cassette chromosome mec.
The study identified three antibiotic resistance genes in the methicillin-resistant Staphylococcus lugdunensis strain JICS135: mecA, blaZ, and aac(6')-aph(2''). These genes confer resistance to β-lactam antibiotics, penicillins, cephalosporins, and aminoglycosides.
Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus.
Avibactam up-regulates the expression of blaZ and pbp2a in S. aureus SF8300, indicating its role in activating the bla and mec divergons.
Determining the Genetic Characteristics of Resistance and Virulence of the "Epidermidis Cluster Group" Through Pan-Genome Analysis.
Two resistance genes, aadD2 and blaZ, were identified in S. caprae SY333 and experimentally validated for their roles in conferring resistance to aminoglycosides and beta-lactams, respectively.
Genetic Characterization of Methicillin-Resistant Staphylococcus aureus Isolates from Human Bloodstream Infections: Detection of MLS(B) Resistance.
The study identified multiple AMR genes in MRSA isolates from bloodstream infections, including blaZ, ermA, ermC, msrA/B, mphC, aac(6')-Ie-aph(2'')-Ia, and ant(4')-Ia, which conferred resistance to various antibiotics such as beta-lactams, macrolides, lincosamides, streptogramin B, and aminoglycosides.
Genome Sequence of a Highly Virulent pvl-positive Vancomycin-intermediate-resistant Staphylococcus aureus Sequence Type 30.
The study identifies the blaZ gene encoding a beta-lactamase and a point mutation in the vraS gene associated with vancomycin intermediate resistance in a pvl-positive USA1100/ST30 methicillin-resistant Staphylococcus aureus isolate.
Cefazolin Inoculum Effect and Methicillin-Susceptible Staphylococcus aureus Osteoarticular Infections in Children.
The study identifies blaZ as a gene encoding a beta-lactamase that contributes to the cefazolin inoculum effect (CzIE) in methicillin-susceptible Staphylococcus aureus (MSSA) isolates, leading to reduced susceptibility to cephalosporins.
Performance of penicillinase detection tests in Staphylococcus epidermidis: comparison of different phenotypic methods.
The study evaluates various phenotypic methods for detecting penicillinase production in Staphylococcus epidermidis, highlighting the importance of the blaZ gene in conferring resistance to penicillin.
Genomic and Long-Term Transcriptomic Imprints Related to the Daptomycin Mechanism of Action Occurring in Daptomycin- and Methicillin-Resistant Staphylococcus aureus Under Daptomycin Exposure.
The study identified various AMR genes and mutations associated with daptomycin resistance in MRSA strains, including genes such as aac(6')-Ib, blaZ, mecA, ermC, fexB, tetM, tet38, dfrC, fosD, and vgaA, as well as mutations in mprF, rpoB, grlA, grlB, and gyrA.
Antibacterial activity and synergy of antibiotics with sanguisorbigenin isolated from Sanguisorba officinalis L. against methicillin-resistant Staphylococcus aureus.
The study shows that sanguisorbigenin (SGB) exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and enhances the efficacy of beta-lactam antibiotics. SGB reduces the expression of mecA, blaR1, and blaZ genes, which are involved in beta-lactam resistance.
Staphylococcus aureus and Methicillin Resistant S. aureus in Nepalese Primates: Resistance to Antimicrobials, Virulence, and Genetic Lineages.
The study identified various antibiotic resistance genes in Staphylococcus aureus isolates from Nepalese primates, including erm(C), aacA-aphD, blaZ, msr(A), and mph(C). These genes conferred resistance to multiple antibiotics such as erythromycin, clindamycin, gentamicin, penicillin, and others.
Characterization of highly virulent community-associated methicillin-resistant Staphylococcus aureus ST9-SCCmec XII causing bloodstream infection in China.
The study identified a highly virulent community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) ST9-SCCmec XII isolate, ZY462471, which exhibited resistance to multiple antibiotics including erythromycin, clindamycin, oxacillin, tetracycline, ciprofloxacin, levofloxacin, and gentamicin. The isolate was found to harbor the mecA, blaZ, and ermC genes, contributing to its resistance profile.
Significant increase in the secretion of extracellular vesicles and antibiotics resistance from methicillin-resistant Staphylococcus aureus induced by ampicillin stress.
The study identifies beta-lactamase (blaZ and SA1529) and penicillin-binding proteins (pbpA, pbp2, pbp3) in EVs from MRSA that contribute to β-lactam antibiotic resistance by degrading antibiotics and altering cell wall synthesis.
β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium.
This review discusses the mechanisms of β-lactam resistance in Staphylococcus aureus, focusing on penicillin-binding proteins (PBPs) and their roles in peptidoglycan biosynthesis. It highlights the importance of PBP2, PBP1, PBP3, and PBP4 in resistance mechanisms and their interactions with β-lactam antibiotics.
Whole genome sequencing of coagulase positive staphylococci from a dog-and-owner screening survey.
The study identified several AMR genes in Staphylococcus aureus isolates, including blaZ, tet(K), norA, lmrS, mepR, and fosB, which confer resistance to penicillin, tetracycline, fluoroquinolones, and fosfomycin. No resistance genes were found in S. pseudintermedius isolates.
Colonization with Staphylococcus aureus and Klebsiella pneumoniae causes infections in a Vietnamese intensive care unit.
The study identifies multidrug-resistant Staphylococcus aureus ST188 and various Klebsiella pneumoniae strains with distinct resistance mechanisms, highlighting the role of colonization in causing infections in ICU patients.
A Preliminary Study: Antibiotic Resistance of Escherichia coli and Staphylococcus aureus from the Meat and Feces of Various South African Wildlife Species.
The study identified antibiotic resistance genes in Escherichia coli and Staphylococcus aureus from wildlife meat and feces, including blaCMY, aadA, sul1, sul2, tetA, tetB, tetK, tetL, tetM, vanA, vanB, and blaZ, which conferred resistance to ampicillin, streptomycin, sulfonamides, tetracycline, vancomycin, and penicillin.
Comparative characterisation of human and ovine non-aureus staphylococci isolated in Sardinia (Italy) for antimicrobial susceptibility profiles and resistance genes.
The study identified various AMR genes in non-aureus staphylococci from ovine and human sources, including blaZ, tetK, msrA, ermC, smr, and qacA/B, which confer resistance to penicillin, tetracycline, erythromycin, and antiseptics.
Genome-Wide Analysis of Staphylococcus aureus Sequence Type 72 Isolates Provides Insights Into Resistance Against Antimicrobial Agents and Virulence Potential.
The study identified several AMR genes in ST72 isolates, including blaZ, aadD, ermC, msr(A), mph(C), tetK, aac(6')-aph(2'), fusC, and dfrG, which confer resistance to various antibiotics. K07-204 showed resistance to methicillin, ampicillin, erythromycin, kanamycin, and tetracycline, while K07-561 exhibited resistance to ampicillin and tetracycline. Additionally, K07-204 was found to be highly resistant to lysostaphin.
Implanted Port Catheter System Infection Caused by Methicillin-resistant Staphylococcus pseudintermedius ST71-SCCmec type III.
The study reports a case of implanted port catheter system infection caused by methicillin-resistant Staphylococcus pseudintermedius ST71-SCC mec III, identifying several AMR genes and mutations including aac(6')-aph(2''), ant(6')-Ia, aph(3')-III, sat4A, mecA, blaZ, erm(B), dfrG, GyrA Ser84Leu, and GrlA Ser80Ile.
Recognition of (Sesc) for Easy Identification of Staphylococcus Epidermidis and Molecular and Phenotypic Study of Β-Lactam Resistance in Staphylococcus Epidermidis Isolates in Isfahan.
The study identified the presence of the blaZ gene in 80% of Staphylococcus epidermidis isolates, indicating β-lactam resistance. Methicillin resistance was detected in 60% of isolates, and high resistance to penicillin (93%) was observed.
Clonal Diversity and Antimicrobial Resistance of Methicillin-Resistant Staphylococcus pseudintermedius Isolated from Canine Pyoderma.
All 31 MRSP isolates were multidrug-resistant, showing resistance to penicillin, macrolides, lincosamides, aminoglycosides, tetracycline, and trimethoprim-sulfamethoxazole. Key resistance genes identified include blaZ, ermB, msr(A/B), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, ant(4')-Ia, tetM, tetK, and dfrG.
Whole Genome Sequencing and Antimicrobial Resistance of Staphylococcus aureus from Surgical Site Infections in Ghana.
The study identified blaZ, mecA, and tet(K) as the main antimicrobial resistance genes in Staphylococcus aureus isolates from surgical site infections in Ghana. These genes conferred resistance to penicillin, methicillin, and tetracycline, respectively.
Phenotypic and Genomic Profiling of Staphylococcus argenteus in Canada and the United States and Recommendations for Clinical Result Reporting.
The study characterizes the antimicrobial resistance genes and mutations in Staphylococcus argenteus isolates from North America, highlighting the presence of mecA, mgrA, arlR, mepR, blaZ, fosB, lmrS, and aac(6')-Ie-APH(2')-Ia, which confer resistance to various antibiotics.
A platform for detecting cross-resistance in antibacterial drug discovery.
The study presents a cross-resistance platform (CRP) consisting of 28 Staphylococcus aureus strains with defined resistance genotypes, designed to detect cross-resistance between established and novel antibacterial agents. The CRP includes various AMR genes and mutations that confer resistance to multiple antibiotic classes.
Staphylococcus aureus in Intensive Pig Production in South Africa: Antibiotic Resistance, Virulence Determinants, and Clonality.
The study identified several AMR genes in S. aureus isolates from intensive pig production in South Africa, including ermC, blaZ, tetK, aac(6')-aph(2"), and mecA, which confer resistance to erythromycin, penicillin, tetracycline, gentamicin, and methicillin respectively.
Clonal Lineages, Antimicrobial Resistance, and PVL Carriage of Staphylococcus aureus Associated to Skin and Soft-Tissue Infections from Ambulatory Patients in Portugal.
The study identified various AMR genes and mutations in S. aureus isolates from SSTIs in ambulatory patients in Portugal, including blaZ, mecA, erm(A), erm(C), msr(A), mph(C), aadD, aacA-aphD, aph(3')-IIIa, and fusC, along with mutations in grlA, gyrA, and fusA associated with fluoroquinolone and fusidic acid resistance.
Culture-Independent Genotyping, Virulence and Antimicrobial Resistance Gene Identification of Staphylococcus aureus from Orthopaedic Implant-Associated Infections.
The study identified blaZ and tetK as genes conferring resistance to penicillin and tetracycline, respectively, in Staphylococcus aureus from orthopaedic implant-associated infections using nanopore shotgun metagenomic sequencing.
Genomic Analysis of Staphylococcus aureus of the Lineage CC130, Including mecC-Carrying MRSA and MSSA Isolates Recovered of Animal, Human, and Environmental Origins.
The study identified several AMR genes in Staphylococcus aureus CC130 isolates, including mecC, blaZ, tet(K), arsB, and arsC. These genes conferred resistance to methicillin, penicillin, tetracycline, arsenite, and arsenate. The presence of the IEC system in some mecC-positive MRSA-CC130 strains suggests potential human adaptation.
Bacterial Targets of Antibiotics in Methicillin-Resistant Staphylococcus aureus.
The paper discusses the mechanisms of antibiotic resistance in methicillin-resistant Staphylococcus aureus (MRSA), focusing on genes such as blaZ, mecA, and dltA, which are involved in beta-lactam and glycopeptide resistance. It highlights the importance of understanding these resistance mechanisms to develop new therapeutic strategies.
Study on Demethoxycurcumin as a Promising Approach to Reverse Methicillin-Resistance of Staphylococcus aureus.
Demethoxycurcumin (DMC) inhibits the expression of PBP2a and beta-lactamase (blaZ), reversing methicillin-resistance in Staphylococcus aureus.
A Real-Time Thermal Sensor System for Quantifying the Inhibitory Effect of Antimicrobial Peptides on Bacterial Adhesion and Biofilm Formation.
The study identified several AMR genes in E. coli and S. aureus isolates, including beta-lactamases (blaOXA-1, blaTEM-1A), chloramphenicol acetyltransferase (catA1), trimethoprim resistance gene (dfrA1), fluoroquinolone resistance gene (floR), sulfonamide resistance genes (sul1, sul2), methicillin resistance gene (mecA), beta-lactamase (blaZ-like), and tetracycline efflux pumps (tet(K), tet(M)).
Characterization of methicillin-resistant Staphylococcus pseudintermedius isolates from Australian animals: discovery of novel sequence types
The study identified several AMR genes in MRSP isolates, including blaZ, mecA, cat-pC221, ermB, ermC, tetM, dfrG, aac6-aph2, ant6-Ia, aph3-III, and aadD, which confer resistance to various antibiotics such as oxacillin, penicillin, chloramphenicol, erythromycin, clindamycin, tetracycline, trimethoprim, and gentamicin.
Prevalence, antibiotic resistance, virulence and genetic diversity of Staphylococcus aureus isolated from bulk tank milk samples of U.S. dairy herds.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from bulk tank milk samples, including norA, aph(3')-Ia, blaZ, and mecA. These genes conferred resistance to fluoroquinolones, aminoglycosides, beta-lactams, and methicillin, respectively.
Antibiotic resistance profiles and population structure of disease-associated Staphylococcus aureus infecting patients in Fort Portal Regional Referral Hospital, Western Uganda.
The study identified various AMR genes in S. aureus isolates from Fort Portal Regional Referral Hospital, including blaZ, dfrA, dfrG, ermA, ermC, msrA, tetK, and tetM, contributing to resistance against multiple antibiotics. Additionally, mecA was detected, indicating methicillin resistance.
Phenotypic and Molecular Traits of Staphylococcus coagulans Associated with Canine Skin Infections in Portugal.
The study identifies the presence of blaZ, mecA, and erm(B) genes in Staphylococcus coagulans isolates, along with various mutations in grlA and gyrA that contribute to fluoroquinolone resistance.
Virulence Factors in Staphylococcus Associated with Small Ruminant Mastitis: Biofilm Production and Antimicrobial Resistance Genes.
The study identified the blaZ gene in several Staphylococcus species, including S. chromogenes, S. aureus, S. warneri, S. auricularis, S. caprae, and S. simulans, which conferred resistance to penicillin. Additionally, the tetK and tetM genes were found in S. aureus isolates, providing resistance to tetracycline.
Molecular Evolution and Adaptation of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) Sequence Type 9.
The study identifies multiple AMR genes and mutations in ST9 S. aureus, including mecA, blaZ, lnu(B), lsa(E), erm(C), fexA, tet(L), dfrG, vwb, and the MDR ST9 element, highlighting their role in multidrug resistance and host adaptation.
Regulation of virulence and beta-lactamase gene expression in Staphylococcus aureus isolates: cooperation of two-component systems in bloodstream superbugs.
The study characterizes the molecular relationships between two-component systems of virulence factors and the expression of the beta-lactamase gene in MRSA-BSI isolates, highlighting the role of genes such as mecA, blaZ, mecI, mecRI, sarA, RNAIII, and SaeRS in β-lactam resistance.
Antimicrobial Resistance Profiles and Genes of Staphylococci Isolated from Mastitic Cow's Milk in Kenya.
The study identified several antimicrobial resistance genes in staphylococci isolated from mastitic cow's milk in Kenya, including blaZ, strB, msrA, ermB, tetM, and tetK, which confer resistance to beta-lactams, streptomycin, erythromycin, and tetracycline.
Analysis of Virulence and Antimicrobial Resistance Gene Carriage in Staphylococcus aureus Infections in Equids Using Whole-Genome Sequencing.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from equids, including blaZ, mupA, lnuA, tetK, tetL, tetM, norA, dfrC, dfrG, dfrK, ermA, ermC, msrA, mphC, qacA/B, qacC, and fosB. An isolate (17-021) was found to carry the lnuA gene and mupA plasmid, conferring resistance to clindamycin and mupirocin. A mutation in the prs gene was associated with phenotypic susceptibility to β-lactam drugs in a mecA-positive isolate.
Prevalence and Characteristics of Staphylococcus aureus Isolated From Retail Raw Milk in Northern Xinjiang, China.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from retail raw milk in northern Xinjiang, China, including blaZ, mecA, ermA, ermB, ermC, aacA-aphD, tetK, tetM, vanA, rpoB, linA, optrA, and cfr, which confer resistance to penicillin, methicillin, oxacillin, erythromycin, gentamicin, tetracycline, vancomycin, rifampin, clindamycin, linezolid, chloramphenicol, and florfenicol.
Environmental Surveillance and Characterization of Antibiotic Resistant Staphylococcus aureus at Coastal Beaches and Rivers on the Island of Hawai'i.
The study identified various antibiotic resistance genes in Staphylococcus aureus isolates from coastal beaches and rivers on the island of Hawai'i, highlighting the presence of multidrug-resistant strains.
Molecular Characterization of Staphylococcus aureus Isolated from Raw Milk Samples of Dairy Cows in Manhiça District, Southern Mozambique.
The study identified several AMR genes in S. aureus isolates from raw milk samples, including blaZ for penicillin resistance, tetK for tetracycline resistance, mecA for methicillin resistance, ermC for erythromycin and clindamycin resistance, and dfrG for co-trimoxazole resistance.
Vancomycin resistant Streptococcus equi subsp. equi isolated from equines suffering from respiratory manifestation in Egypt.
The study identified vancomycin-resistant Streptococcus equi subsp. equi isolates carrying the vanA gene, along with tetK, blaZ, and fexA genes, indicating resistance to vancomycin, tetracycline, penicillin, and chloramphenicol, respectively.
High Proportion of Oxacillin-Susceptible mecA-Positive Staphylococcus aureus Isolates from Post-Viral Acute Rhinosinusitis Patients.
The study identified a high proportion of oxacillin-susceptible mecA-positive Staphylococcus aureus isolates, highlighting the need for genetic testing to accurately detect methicillin-resistant S. aureus.
Misidentification of meticillin-resistant Staphylococcus aureus by the Cepheid Xpert MRSA NxG assay, the Netherlands, February to March 2021.
The study reports two false-negative results in detecting meticillin-resistant Staphylococcus aureus (MRSA) using the Cepheid Xpert MRSA NxG assay. The isolates were resistant to multiple antibiotics, including beta-lactams, aminoglycosides, and tetracyclines, and carried resistance genes such as blaZ, mecA, erm(T), aac(6')-aph(2"), tet(L), and tet(M).
Epidemiology of Staphylococcus pseudintermedius in cats in Poland.
The study characterized the antibiotic resistance profiles of Staphylococcus pseudintermedius isolates from cats in Poland, identifying several resistance genes including blaZ, mecA, aac(6')Ie-aph(2")Ia, ermB, tet(L), and tet(M).
Antibiotic resistance in the pathogenic foodborne bacteria isolated from raw kebab and hamburger: phenotypic and genotypic study.
The study identified several antibiotic resistance genes, including blaTEM, blaSHV, blaZ, and mecA, in various foodborne pathogens isolated from raw kebab and hamburger samples. These genes were found to confer resistance to multiple antibiotics, highlighting the presence of multidrug-resistant bacteria in these food products.
A survey of prevalence and phenotypic and genotypic assessment of antibiotic resistance in Staphylococcus aureus bacteria isolated from ready-to-eat food samples collected from Tehran Province, Iran.
The study identified several AMR genes in S. aureus isolates from ready-to-eat food samples, including blaZ, aacA-D, tetK, ermA, and gyrA, which conferred resistance to penicillin, aminoglycosides, tetracyclines, macrolides, and fluoroquinolones.
Shotgun-metagenomics based prediction of antibiotic resistance and virulence determinants in Staphylococcus aureus from periprosthetic tissue on blood culture bottles.
The study identified three antibiotic resistance genes (blaZ, fosB, and tet38) in Staphylococcus aureus using shotgun-metagenomics. These genes were associated with resistance to penicillin, fusidic acid, and tetracycline.
Co-Carriage of Metal and Antibiotic Resistance Genes in Sewage Associated Staphylococci.
The study identified the co-carriage of antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) in sewage-associated staphylococci, particularly highlighting the presence of blaZ, cadD, cadX, erm(C), and Vga(A)LC in various isolates.
Molecular Characterization of Staphylococcus aureus Isolated from Human and Food Samples in Northern Algeria.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from human and food samples in northern Algeria, including blaZ, ermB, ermC, aphA3, sat, tetK, and tetM.
Antimicrobial Susceptibility Testing for Staphylococcus lugdunensis.
The study evaluated antimicrobial susceptibility testing methods for Staphylococcus lugdunensis, identifying blaZ and mecA as key genes responsible for penicillin and oxacillin resistance, respectively.
Antibiotic sensitivity patterns in Staphylococcus spp. isolated from goat milk in association with molecular detection of antibiotic resistance genes.
The study identified several antibiotic resistance genes in Staphylococcus spp. isolated from goat milk, including blaZ, mecA, tetK, and tetM, which confer resistance to penicillin, methicillin, and tetracycline.
Antimicrobial resistance, virulence genes and biofilm formation in Enterococcus species isolated from milk of sheep and goat with subclinical mastitis.
The study identified several antimicrobial resistance genes, including blaZ, vanA, ermB, tetM, and optrA, in Enterococcus species isolated from subclinical mastitic milk. High rates of multidrug resistance were observed, particularly against oxacillin, vancomycin, and linezolid.
The Genetic Relatedness and Antimicrobial Resistance Patterns of Mastitis-Causing Staphylococcus aureus Strains Isolated from New Zealand Dairy Cattle.
The study identified 14 AMR-associated genes, including blaI, blaR1, blaZ, tet(38), merR1, and norB4, in S. aureus isolates from New Zealand dairy cattle. These genes were associated with resistance to penicillin, tetracycline, mercury, and ciprofloxacin. The presence of resistance genes remained low, and no significant associations were found between resistance genes and antimicrobial usage or dry cow therapy.
Distribution and Clonal Diversity of Staphylococcus aureus and Other Staphylococci in Surface Waters: Detection of ST425-t742 and ST130-t843 mecC-Positive MRSA Strains.
The study identified mecC-positive MRSA strains ST425-t742 and ST130-t843 in surface waters, along with various AMR genes such as mecC, blaZ, ermT, msr(A/B), vgaA, tetL, mecA, mph(C), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, dfrA, fusB, and catpC221 in Staphylococcus aureus and coagulase-negative staphylococci.
Molecular Typing and Antimicrobial Susceptibility Profiles of Streptococcus uberis Isolated from Sheep Milk.
The study identified resistance genes ermB, ermC, blaZ, tetM, tetO, and tetK in Streptococcus uberis isolates from sheep milk, contributing to resistance against erythromycin, penicillin, and tetracycline.
First Report of CC5-MRSA-IV-SCCfus "Maltese Clone" in Bat Guano.
The study reports the first isolation of CC5-MRSA-IV-SCCfus 'Maltese Clone' from bat guano in Algeria, highlighting the presence of fusidic acid resistance element fusC, fosfomycin resistance gene fosB, and penicillinase gene blaZ in the MRSA isolates.
Genetic Characterization of Staphylococcus aureus From Subclinical Mastitis Cases in Dairy Cows in Rwanda.
The study identified the blaZ gene conferring penicillin resistance in 84% of the isolates, tet(K) or tetM genes for tetracycline resistance in 20% of the isolates, and the dfrG gene for trimethoprim resistance in 28% of the isolates.
Nucleotide sequence of the Staphylococcus aureus PC1 beta-lactamase gene.
Nucleotide sequence of the Staphylococcus aureus PC1 beta-lactamase gene.
Prevalence and antimicrobial resistance profiling of Staphylococcus aureus isolated from traditional cheese in Yunnan, China.
The study identified 18 antimicrobial resistance genes in Staphylococcus aureus strain DC.RB_015, including mecA, blaZ, mepA, tet(K), tet(38), arlR, arlS, norA, mgrA, LmrS, APH(3′)-IIIa, aad(6), ErmB, SAT-4, mecR1, GlpT, murA, and bacA, which confer resistance to various antibiotics such as methicillin, beta-lactam, tetracycline, fluoroquinolone, macrolide, aminoglycoside, nucleoside, fosfomycin, and bacitracin.
Antibiotic Resistance and Pathogenomics of Staphylococci Circulating in Novosibirsk, Russia.
The study identified several AMR genes in Staphylococcus isolates from Novosibirsk, Russia, including mecA, blaZ, aac(6')-Ie-aph(2'')-Ia, ant(4')-Ia, aph(3')-IIIa, ermA, ermC, msrA, norA, dfrC, fosB, and mphC, which confer resistance to beta-lactams, aminoglycosides, macrolides, quinolones, and other antibiotics.
Whole Genome Sequencing of Staphylococci Isolated From Bovine Milk Samples.
The study identified several antimicrobial resistance genes in non-aureus staphylococci (NAS) and Staphylococcus aureus, including lnuA, blaZ, ermA, ermB, ermC, mphC, msrA, aadD, aac-aph, str, and norA. These genes conferred resistance to lincomycin, penicillin, macrolides, aminoglycosides, and multiple antibiotics.
Genomic epidemiology and characterisation of penicillin-sensitive Staphylococcus aureus isolates from invasive bloodstream infections in China: an increasing prevalence and higher diversity in genetic typing be revealed.
The study identified blaZ gene variants with specific amino acid changes that influenced penicillin susceptibility in Staphylococcus aureus isolates, highlighting the importance of genetic characterization in understanding antimicrobial resistance mechanisms.
Staphylococcus ratti sp. nov. Isolated from a Lab Rat.
The study identifies Staphylococcus ratti sp. nov. as a novel species isolated from a lab rat, highlighting its unique phenotypic and genomic features, including the presence of a beta-lactamase gene (blaZ) that confers resistance to penicillin.
Prevalence and Characterization of PVL-Positive Staphylococcus aureus Isolated from Raw Cow's Milk.
The study identified the presence of blaZ and mecA genes in PVL-positive Staphylococcus aureus isolates from raw cow's milk, indicating resistance to penicillin, ampicillin, and methicillin.
Antimicrobial and Biocide Resistance among Feline and Canine Staphylococcus aureus and Staphylococcus pseudintermedius Isolates from Diagnostic Submissions.
The study identified various antimicrobial resistance genes in feline and canine Staphylococcus aureus and Staphylococcus pseudintermedius isolates, including blaZ, mecA, mecC, tet(K), tet(M), erm(A), erm(B), erm(C), erm(T), msr(A), aadE, aacA-aphD, aphA3, aadD, dfrG, lnu(B), and lsa(E). These genes conferred resistance to multiple antibiotics such as penicillins, tetracyclines, macrolides, aminoglycosides, and others.
Comparative Analysis of Bacillus cereus Group Isolates' Resistance Using Disk Diffusion and Broth Microdilution and the Correlation between Antimicrobial Resistance Phenotypes and Genotypes.
The study identified several antimicrobial resistance genes in Bacillus cereus group isolates, including beta-lactamase-encoding genes (bla1, blaZ, blaTEM), mph for erythromycin resistance, rph for rifampicin resistance, and fosB for fosfomycin resistance. These genes were detected using ABRIcate and MEGARes 2.0 database, and their association with resistance phenotypes was analyzed.
Survey of Staphylococcus aureus carriage by free-living red deer (Cervus elaphus): Evidence of human and domestic animal lineages.
The study identified several Staphylococcus aureus lineages in free-living red deer, including CC425, CC2671, and CC350, which were prevalent in nasal and intestinal samples. Resistance genes such as blaZ, blaI, blaR, and ermA were detected, along with virulence factors like lukM/lukF-P83, seb, sak, chp, and scn. No methicillin-resistant S. aureus (MRSA) was found.
Extensive metagenomic analysis of the porcine gut resistome to identify indicators reflecting antimicrobial resistance.
The study identified 1295 open reading frames recognized as antimicrobial resistance protein-coding genes in porcine gut microbiomes, highlighting tetracycline, aminoglycoside, and MLS resistance as predominant. Key ARGs like tet(W/N/W), APH(3')-IIIa, and ErmB were found to be highly prevalent and associated with resistance to specific antibiotics.
High prevalence of antibiotic resistance in pathogenic foodborne bacteria isolated from bovine milk.
The study identified bla TEM, bla SHV, mec A, and bla Z genes in E. coli, Salmonella spp., and S. aureus isolates from bovine milk, highlighting the high prevalence of antibiotic resistance in foodborne pathogens.
A One Health Approach Molecular Analysis of Staphylococcus aureus Reveals Distinct Lineages in Isolates from Miranda Donkeys (Equus asinus) and Their Handlers.
The study identified various antimicrobial resistance genes in Staphylococcus aureus and coagulase-negative staphylococci (CoNS) isolates from Miranda donkeys and their handlers, including blaZ, aph(3')-IIIa, tetK, tetL, tetM, lnuA, ermB, ermC, mecA, and optrA. These genes confer resistance to penicillins, aminoglycosides, tetracyclines, lincomycins, macrolides, lincosamides, streptogramin B, methicillin, and linezolid.
First Report of a Methicillin-Resistant, High-Level Mupirocin-Resistant Staphylococcus argenteus.
The study reports the first methicillin-resistant, high-level mupirocin-resistant Staphylococcus argenteus isolate, which harbors the mupA gene on a plasmid and the blaZ gene on another plasmid.
Multidrug-resistant and enterotoxigenic methicillin-resistant Staphylococcus aureus isolated from raw milk of cows at small-scale production units.
The study identified multidrug-resistant and enterotoxigenic methicillin-resistant Staphylococcus aureus (MRSA) in raw milk from cows at small-scale production units. The MRSA isolates exhibited resistance to β-lactams, tetracycline, and norfloxacin, with specific resistance genes such as blaZ, mecA, tetK, and norA detected. Enterotoxin genes like seb were also identified in MRSA isolates.
First study on diversity and antimicrobial-resistant profile of staphylococci in sports animals of Southern Thailand.
The study identified methicillin-resistant staphylococci (MRS) in sports animals, with a high prevalence of mecA and blaZ genes. S. sciuri was the most common species, showing high resistance to penicillins and cephalosporins.
Virulence and antimicrobial resistance gene profiles of Staphylococcus aureus associated with clinical mastitis in cattle.
The study identified blaZ and mecA as the primary antimicrobial resistance genes in S. aureus isolates from bovine mastitis, with high prevalence of blaZ (92.73%) and mecA (23.64%).
The Emergence of a Multidrug-Resistant and Pathogenic ST42 Lineage of Staphylococcus haemolyticus from a Hospital in China.
The study identifies the ST42 lineage of Staphylococcus haemolyticus as a multidrug-resistant and pathogenic clone with a high burden of antibiotic resistance genes (ARGs) and virulence determinants.
Antimicrobial Resistance and Clonal Lineages of Staphylococcus aureus from Cattle, Their Handlers, and Their Surroundings: A Cross-Sectional Study from the One Health Perspective.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from cattle, farm workers, and their environment, highlighting the potential for transmission between hosts and the need for monitoring AMR in One Health contexts.
Antimicrobial Susceptibility, and Molecular Characterization of Staphylococcus aureus Isolated From Different Raw Milk Samples in China.
The study identified several AMR genes in Staphylococcus aureus isolated from raw milk samples in China, including blaZ, aac(6')-aph(2"), tet(M), mecA, cfxA, ant(4')-Ia, and fexA. These genes conferred resistance to various antibiotics such as Penicillin G, Tetracycline, Gentamicin, Kanamycin, Cefoxitin, and Chloramphenicol.
Description of Staphylococcal Strains from Straw-Coloured Fruit Bat (Eidolon helvum) and Diamond Firetail (Stagonopleura guttata) and a Review of their Phylogenetic Relationships to Other Staphylococci.
The study describes the characterization of Staphylococcal strains from Straw-coloured fruit bats and a Diamond firetail, identifying them as belonging to the newly described species S. roterodami and S. singaporensis. The isolates exhibited unique genetic features and were found to be closely related to S. argenteus and S. schweitzeri.
Comparative Phenotypic and Genomic Features of Staphylococci from Sonication Fluid of Orthopedic Implant-Associated Infections with Poor Outcome.
The study identified various AMR genes in Staphylococcus isolates from orthopedic implant-associated infections, including mecA, blaZ, aminoglycoside modifying enzymes, and erythromycin resistance genes, highlighting the prevalence of multidrug resistance among these isolates.
Detection of Antibiotic Resistance, Virulence Gene, and Drug Resistance Gene of Staphylococcus aureus Isolates from Bovine Mastitis.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from bovine mastitis, including blaZ, aacA-aphD, tetK, tetM, norA, norB, norC, and mecA. These genes were associated with resistance to various antibiotics such as penicillin G, gentamicin, kanamycin, tetracycline, and ciprofloxacin.
Genomics of Staphylococcus aureus and Staphylococcus epidermidis from Periprosthetic Joint Infections and Correlation to Clinical Outcome.
The study identified blaZ as a gene associated with penicillin resistance in Staphylococcus aureus and Staphylococcus epidermidis, with higher prevalence in strains from unresolved infections.
Assessment of multidrug-resistant Listeria monocytogenes in milk and milk product and One Health perspective.
The study identified multiple antimicrobial resistance genes in Listeria monocytogenes isolates from milk and milk products, including beta-lactamase genes (bla TEM, bla SHV, bla Z), tetracycline resistance genes (tet A, tet D, tet G, tet K, tet M), sulfonamide resistance genes (sul 1, sul 2), and an aminoglycoside resistance gene (aph (3)-IIa (aphA2)).
Outbreak of methicillin-resistant Staphylococcus aureus sequence type 1, spa type t1784, in an equine hospital in Japan.
The study identified MRSA ST1-t1784 isolates from horses and veterinarians, which exhibited resistance to oxacillin, gentamycin, and levofloxacin due to mutations in gyrA and grlA, along with the presence of resistance genes aac(6')-aph(2''), blaZ, mecA, and qacA.
Antimicrobial resistance and genomic analysis of staphylococi isolated from livestock and farm attendants in Northern Ghana.
The study identified several AMR genes in staphylococci from livestock and farm attendants in Northern Ghana, including mecA1, mecA, tet(K), tet(L), tet(M), cat(pC221), sal(A), aadD, dfrK, dfrG, erm(B), fosB, aac(6')-aph(2''), and blaZ, which confer resistance to various antibiotics such as beta-lactams, tetracyclines, chloramphenicol, aminoglycosides, and macrolides.
Whole-Genome Sequence of Multidrug-Resistant Methicillin-Resistant Staphylococcus epidermidis Carrying Biofilm-Associated Genes and a Unique Composite of SCCmec.
The study identified multiple antimicrobial resistance genes in multidrug-resistant methicillin-resistant Staphylococcus epidermidis isolates, including mecA, blaZ, fusB, fosB, aadD, aac(6')-aph(2"), tet(K), dfrG, msr(A), and qacA. These genes contribute to resistance against various antibiotics such as methicillin, penicillin, fusidic acid, fosfomycin, aminoglycosides, tetracycline, trimethoprim, macrolides, and chlorhexidine.
Methicillin Resistant Staphylococci Isolated from Goats and Their Farm Environments in Saudi Arabia Genotypically Linked to Known Human Clinical Isolates: a Pilot Study.
The study identified several AMR genes in methicillin-resistant staphylococci isolates from goats and their farm environments in Saudi Arabia, including mecA, blaZ, norA, lmrS, mepA, mepR, arlR, arlS, tet(38), mecR1, dfrC, fusC, fosB, fexA, tetM, msrA, mphC, fusB, APH(3′)-IIIa, tetK, and dfrG. These genes confer resistance to various antibiotics such as penicillins, fluoroquinolones, aminoglycosides, macrolides, phenicols, diaminopyrimidines, oxazolidinones, tetracyclines, and fosfomycin.
Comparison between Some Phenotypic and Genotypic Methods for Assessment of Antimicrobial Resistance Trend of Bovine Mastitis Staphylococcus aureus Isolates from Bulgaria.
The study identified blaZ, mecA, ermC, and tetK genes in Staphylococcus aureus isolates from bovine mastitis cases in Bulgaria, highlighting resistance to penicillin, methicillin, erythromycin, and tetracycline.
Microbiological and Molecular Features Associated with Persistent and Relapsing Staphylococcus aureus Prosthetic Joint Infection.
The study identified several AMR genes and mutations in Staphylococcus aureus isolates from persistent and relapsing prosthetic joint infections, including aac(6')-aph(2"), dfrB, blaZ, grlA, gyrA, and norA. These genes and mutations were experimentally validated and associated with resistance to various antibiotics.
Nasal Staphylococcus aureus and S. pseudintermedius carriage in healthy dogs and cats: a systematic review of their antibiotic resistance, virulence and genetic lineages of zoonotic relevance.
The study identifies various AMR genes such as mecA, blaZ, tet(M), erm(B), aac(6')-aph(2"), aadD, ant(6)-Ia, and sat4 in Staphylococcus aureus and S. pseudintermedius isolates from healthy dogs and cats, indicating widespread antibiotic resistance.
Molecular characterization of multi-drug-resistant Staphylococcus aureus in mastitis bovine milk from a dairy farm in Anhui, China.
The study identified multidrug-resistant Staphylococcus aureus in bovine milk samples, highlighting the presence of resistance genes blaZ, ermC, rpoB, and ant(4')-la, which confer resistance to penicillin, macrolides, rifampicin, and spectinomycin, respectively.
Diversity and emergence of multi-resistant Staphylococcus spp. isolated from subclinical mastitis in cows in of the state of Piauí, Brazil.
The study identified the presence of blaZ, tetL, tetM, mecA, and vanB genes in Staphylococcus spp. isolates from subclinical mastitis in cows in Piauí, Brazil, indicating multidrug resistance.
Whole-Genome Analysis of Staphylococcus aureus Isolates from Ready-to-Eat Food in Russia.
The study identified multiple antimicrobial resistance (AMR) genes in Staphylococcus aureus isolates from ready-to-eat food in Russia, including blaZ, mecA, inuA, cat, ermC, dfrG, dfrK, aaC, aaD, ant(9)-Ia, tet(K), tet(cluster), erm(A), erm(C), cat(pC194), and fexA. These genes conferred resistance to various antibiotics such as penicillins, lincosamides, phenicols, macrolides, aminoglycosides, tetracyclines, and fluoroquinolones.
Pathogenic potential and antimicrobial resistance of Staphylococcus pseudintermedius isolated from human and animals.
The study identified the presence of the mecA and blaZ genes in Staphylococcus pseudintermedius isolates, indicating resistance to methicillin and penicillin, respectively. Animal isolates exhibited higher antibiotic resistance compared to human isolates.
Genomic Characterization and Antimicrobial Susceptibility of Dromedary-Associated Staphylococcaceae from the Horn of Africa.
The study identified several antimicrobial resistance genes in Staphylococcaceae isolates from camels and cattle in East Africa, including tet(K), blaZ, blaARL, mecA, mecA1, msrA, mphC, salA, dfrG, aacA-aphD, and str. These genes were associated with resistance to tetracycline, benzylpenicillin, oxacillin, erythromycin, clindamycin, trimethoprim, gentamicin, and streptomycin.
First Finding of a Methicillin-Resistant Staphylococcus aureus (MRSA) t304/ST6 from Bovine Clinical Mastitis.
The study reports the first case of methicillin-resistant Staphylococcus aureus (MRSA) t304/ST6 isolated from bovine clinical mastitis, confirming the isolate as MRSA through detection of the mecA gene and demonstrating resistance to cefoxitin and penicillin.
Emergence of Cfr-Mediated Linezolid Resistance among Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) from Healthy Pigs in Portugal.
The study identified the cfr gene as a mediator of linezolid resistance in livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) from healthy pigs in Portugal. Additional resistance genes such as blaZ, mecA, fexA, tet(M), and tet(K) were also characterized.
Relationship between Biofilm Formation and Antibiotic Resistance and Adherence Genes in Staphylococcus aureus Strains Isolated from Raw Cow Milk in Shahrekord, Iran.
The study identified blaZ, mecA, and Aac-D as the most prevalent antibiotic resistance genes in S. aureus isolates from raw cow milk, with blaZ showing the highest prevalence and correlating with resistance to beta-lactam antibiotics.
Antimicrobial Resistance and Virulence Genes in Staphylococci Isolated from Aviary Capercaillies and Free-living Birds in South-eastern Poland.
The study identified several AMR genes in Staphylococcus isolates from birds, including mecA, blaZ, msrA/B, ermC, mphC, tetK, tetM, cfr, norA, aac(6')-aph(2"), sea, and tst. These genes conferred resistance to various antibiotics such as methicillin, beta-lactams, macrolides, tetracyclines, chloramphenicol, florfenicol, fluoroquinolones, and aminoglycosides.
Global Downregulation of Penicillin Resistance and Biofilm Formation by MRSA Is Associated with the Interaction between Kaempferol Rhamnosides and Quercetin.
The study identifies that kaempferol rhamnosides and quercetin interact with MRSA to downregulate penicillin resistance and biofilm formation, primarily through the downregulation of blaZ, sarA, and sigB.
First Genome-Based Characterisation and Staphylococcal Enterotoxin Production Ability of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus Strains Isolated from Ready-to-Eat Foods in Algiers (Algeria).
The study identified several AMR genes and mutations in S. aureus strains isolated from ready-to-eat foods in Algeria, including blaZ, ermB, lmrS, tet(L), tet(38), aph(3')-IIIa, ant(6)-I, mecA, and a gyrA mutation (S84L) conferring resistance to various antibiotics.
Phenotypic and genomic assessment of the potential threat of human spaceflight-relevant Staphylococcus capitis isolates under stress conditions.
All four Staphylococcus capitis strains were found to be resistant to fosfomycin, with no significant differences in antibiotic susceptibility among the strains.
Concordance between Antimicrobial Resistance Phenotype and Genotype of Staphylococcus pseudintermedius from Healthy Dogs.
The study identified 17 antibiotic resistance genes in Staphylococcus pseudintermedius isolates from healthy dogs, including blaZ, mecA, ermB, tetM, aac(6')-aph(2''), ant(6)-Ia, aph(3')-IIIa, spw, str, and dfrG. It also found mutations in gyrA and parC genes associated with fluoroquinolone resistance, and mutations in rpoB and clpP linked to vancomycin resistance.
Virulence Determinants and Methicillin Resistance in Biofilm-Forming Staphylococcus aureus from Various Food Sources in Bangladesh.
The study identified the methicillin resistance gene mecA, beta-lactam resistance gene blaZ, and tetracycline resistance genes tetA and tetC in biofilm-forming Staphylococcus aureus isolates from food sources in Bangladesh.
Detection of Methicillin-Resistant Staphylococcus aureus in Clinical and Subclinical Mastitis in Ruminants and Studying the Effect of Novel Green Synthetized Nanoparticles as One of the Alternative Treatments.
The study identified methicillin-resistant Staphylococcus aureus (MRSA) in mastitic milk samples from ruminants and characterized resistance genes including mecA, blaZ, ermB, tetM, and tetK. Green synthesized titanium dioxide nanoparticles (TiO2 NPs) showed potent antibacterial activity against MRSA.
Dispersion and persistence of antimicrobial resistance genes among Staphylococcus spp. and Mammaliicoccus spp. isolated along a swine manure treatment plant.
The study identified multiple antimicrobial resistance genes, including fexA, ermC, cfr, aac(6')-aph(2''), dfrG, tetK, blaZ, mecA, norA, tetM, and ermA, in Staphylococcus and Mammaliicoccus species isolated from a swine manure treatment plant, indicating widespread resistance to various antibiotics.
Diversity, heavy metals, and antibiotic resistance in culturable heterotrophic bacteria isolated from former lead–silver–zinc mine heap in Tarnowskie Gory (Silesia, Poland).
The study identified the blaZ gene in Staphylococcus spp., which confers resistance to ampicillin. This gene was experimentally validated through PCR and electrophoresis.
Methicillin-Resistant Staphylococcus aureus from Diabetic Foot Infections in a Tunisian Hospital with the First Detection of MSSA CC398-t571.
The study identified several AMR genes in S. aureus isolates from diabetic foot infections, including blaZ, erm(B), erm(A), msrA, tet(M), tet(K), tet(L), aac(6')-aph(2"), ant(4')-Ia, and fexA. These genes conferred resistance to various antibiotics such as penicillin, erythromycin, tetracycline, gentamicin, tobramycin, and chloramphenicol.
Phenotypic and Genotypic Virulence Characterisation of Staphylococcus pettenkoferi Strains Isolated from Human Bloodstream and Diabetic Foot Infections.
The study characterizes several AMR genes and mutations in Staphylococcus pettenkoferi strains, including blaZ, mecA, ant(9)-Ia, tet(K), ermA, vgaA, and fosB, as well as mutations in rpoB, gyrA, glrA, and grlB.
Staphylococcus aureus from Subclinical Cases of Mastitis in Dairy Cattle in Poland, What Are They Hiding? Antibiotic Resistance and Virulence Profile.
The study identified tet(K) and blaZ as the primary antibiotic resistance genes in Staphylococcus aureus isolates from subclinical mastitis cases in Polish dairy cattle, with resistance to tetracycline and penicillin being prevalent.
Comparative Genomic Analysis of a Multidrug-Resistant Staphylococcus hominis ShoR14 Clinical Isolate from Terengganu, Malaysia, Led to the Discovery of Novel Mobile Genetic Elements.
The study identified multiple AMR genes in the multidrug-resistant S. hominis ShoR14 isolate, including tetK, norA, aac(6')-aph(2"), aadD, blaZ, mecA, mupA, fusC, ermC, sul4, dfrC, and catA7, which contribute to resistance against various antibiotics.
Characteristics of Staphylococcus aureus Isolated from Patients in Busia County Referral Hospital, Kenya.
The study identified S. aureus isolates carrying genes conferring resistance to penicillin-G, trimethoprim, tetracycline, erythromycin, gentamicin, and other antibiotics. Key resistance genes included blaZ, tetK, tetM, dfrG, ermA, ermC, aacA-aphD, aad9, and mecA.
Insights into the Effects and Mechanism of Andrographolide-Mediated Recovery of Susceptibility of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics.
Andrographolide (AP) restores susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics by inhibiting the beta-lactamase BlaZ, downregulating resistance genes mecA and blaZ, and disrupting cell wall homeostasis.
A culture-, amplification-independent, and rapid method for identification of pathogens and antibiotic resistance profile in bovine mastitis milk.
The study identified AMR genes such as tet(38), fosB-Saur, and blaZ in bovine mastitis milk using a rapid, culture-independent method involving MinION nanopore sequencing and optimized DNA isolation protocols.
Bats Are Carriers of Antimicrobial-Resistant Staphylococcaceae in Their Skin.
The study identified the mecA gene in a Staphylococcus haemolyticus isolate and the blaZ gene in various Staphylococcaceae species, indicating resistance to cefoxitin and penicillin, respectively.
Phylogenetic Analysis and Virulence Characteristics of Methicillin-Resistant Staphylococcus aureus ST45 in China: a Hyper-Virulent Clone Associated with Bloodstream Infections.
The study identifies the presence of antimicrobial resistance genes blaZ, tetK, aac6 aph2, and ermC in MRSA ST45 isolates, highlighting their resistance to beta-lactam, tetracycline, aminoglycoside, and macrolide-lincosamide-streptomycin antibiotics. Additionally, the research emphasizes the high virulence potential of ST45-MRSA isolates in causing bloodstream infections.
Panton-Valentine Leukocidin-Positive CC398 MRSA in Urban Clinical Settings, the Netherlands.
The study identified PVL-positive CC398 MRSA strains in the Netherlands, highlighting their potential for community acquisition and the importance of genomic surveillance for early detection.
A multicentre study reveals dysbiosis in the microbial co-infection and antimicrobial resistance gene profile in the nasopharynx of COVID-19 patients.
The study identified a variety of antimicrobial resistance genes in the nasopharynx of COVID-19 patients, including beta-lactamases, macrolide-lincosamide-streptogramin resistance genes, tetracycline resistance genes, and others. These genes were found to be prevalent in both symptomatic and asymptomatic patients, highlighting the importance of monitoring antimicrobial resistance in the context of the pandemic.
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.
The study identified various AMR genes in sepsis-causing bacteria, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others, highlighting the complexity of AMR in these pathogens.
Antimicrobial resistance in methicillin-resistant staphylococcus aureus.
The study identifies key genes and mutations involved in methicillin-resistant Staphylococcus aureus (MRSA) resistance, including mecA, blaZ, mprF, and cfr, along with specific mutations in 23S rRNA that contribute to resistance against beta-lactams, daptomycin, and linezolid.
Prevalence, multiple antibiotic resistance and virulence profile of methicillin-resistant Staphylococcus aureus (MRSA) in retail poultry meat from Edo, Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant Staphylococcus aureus (MRSA) isolated from retail poultry meat in Edo, Nigeria, highlighting the prevalence of multidrug-resistant MRSA and the presence of virulence factors that pose a public health concern.
Intra-host variation of genetic lineages or AMR genotypes of CoPS
The study identifies various AMR genes including blaZ, dfrA, dfrG, ermB, catA, aac6′-aph2″, tet(M), dfrK, and ant4′ in Staphylococcus aureus and Staphylococcus pseudintermedius isolates. Additionally, a mutation in grlA (S80F) was found to confer fluoroquinolone resistance.
Staphylococcus aureus Carriage in the Nasotracheal Cavities of White Stork Nestlings (Ciconia ciconia) in Spain: Genetic Diversity, Resistomes and Virulence Factors.
The study identified several AMR genes in Staphylococcus aureus isolates from white stork nestlings, including blaZ, ermA, ermT, tetK, and lnuA, which confer resistance to penicillin, erythromycin, clindamycin, and tetracycline. Most isolates were methicillin-susceptible (MSSA) with low levels of AMR.
The Characterization and Beta-Lactam Resistance of Staphylococcal Community Recovered from Raw Bovine Milk.
The study identified the presence of beta-lactam resistance genes blaZ and mecA in staphylococcal isolates from raw bovine milk, indicating a low level of beta-lactam resistance.
Genomic Characterization of Staphylococcus aureus in Wildlife.
The study identified several AMR genes in S. aureus isolates from wildlife in Eastern Spain, including blaZ, mecA, mecC, and fosB, which confer resistance to penicillin, methicillin, and fosfomycin. These findings highlight the potential of wildlife as a reservoir for clinically relevant AMR strains.
Antimicrobial Resistance in Vaginal Bacteria in Inseminated Mares.
The study identified several AMR genes in E. coli, S. equisimilis, and S. simulans, including sul1, sul2, dfrA1, dfrA14, tet(A), mdf(A), blaEC-5, blaTEM-1, blaTEM-1B, blaEC, catB3, aadA5, aph(6)-ld, lsaC, and blaZ, which conferred resistance to various antibiotics.
Complete Genome Sequence and Analysis of a ST573 Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus SauR3 Clinical Isolate from Terengganu, Malaysia.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant S. aureus isolate SauR3, including blaZ, mecA, norA, norC, sdrM, ermC, lmrS, msrA, mphC, aph(3′)-IIIa, aadE, aac(6′)Ie-aph(2″)Ia, fosB, and SAT-4, contributing to resistance against various antibiotics.
Association of multilocus sequencing types and antimicrobial resistance profiles of methicillin-resistant Mammaliicoccus sciuri in animals in Southern Thailand.
The study identified mecA and blaZ as the primary antimicrobial resistance genes in methicillin-resistant Mammaliicoccus sciuri isolates from Southern Thailand, with no detection of mecC. Multiple multilocus sequence types (MLSTs) were found, highlighting the diversity of resistant strains.
Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococcaceae (MRS) and Mammaliicocci (MRM) in Dromedary Camels from Algeria: First Detection of SCCmec-mecC Hybrid in Methicillin-Resistant Mammaliicoccus lentus.
The study identified methicillin-resistant Staphylococcus and Mammaliicoccus species in dromedary camels in Algeria, including the first detection of a SCCmec-mecC hybrid in Mammaliicoccus lentus. Key resistance genes identified include mecA, mecC, blaZ, aadD, dfrG, ermB, ermA, msrA, mphC, fosB, fusB, and tet(K).
The Plasmidomic Landscape of Clinical Methicillin-Resistant Staphylococcus aureus Isolates from Malaysia.
The study identified various plasmid-borne antimicrobial resistance genes in Malaysian MRSA isolates, including ermC, cat, tetK, tetL, aadD, aac(6')-Ie-aph(2")-Ia, lnuA, cadAC, cadDX, copB, mco, arsB, arsC, and qacA, contributing to multidrug resistance.
Progress in the Prevalence, Classification and Drug Resistance Mechanisms of Methicillin-Resistant Staphylococcus aureus.
The paper reviews the prevalence, classification, and drug resistance mechanisms of methicillin-resistant Staphylococcus aureus (MRSA), focusing on the roles of mecA, mecC, and vanA genes in conferring resistance to beta-lactam and glycopeptide antibiotics.
Detecting patterns of accessory genome coevolution in Staphylococcus aureus using data from thousands of genomes.
The study identifies coevolving genes in Staphylococcus aureus, highlighting interactions among antibiotic resistance genes, mobile genetic elements, and virulence factors. Key findings include the coevolution of beta-lactam resistance genes (blaZ, blaI, blaR1), metal resistance genes (cadA, cadC, copB, mco), and plasmid replication genes (repD, repE, repN, pre).
Staphylococcus aureus in the Processing Environment of Cured Meat Products.
The study identified the blaZ gene, which encodes a beta-lactamase, in S. aureus isolates resistant to penicillin G. The gene was detected in all isolates resistant to penicillin.
Identification and Characterization of a Vancomycin Intermediate-Resistant Staphylococcus haemolyticus Isolated from Guangzhou, China.
The study identifies vancomycin intermediate-resistant Staphylococcus haemolyticus SH-1 carrying multiple drug resistance genes and novel mutations in WalK gene associated with vancomycin resistance.
Antibiotic Susceptibility Profiling of Human Pathogenic Staphylococcus aureus Strains Using Whole Genome Sequencing and Genome-Scale Annotation Approaches.
The study identified several AMR genes in multidrug-resistant S. aureus strains, including blaZ, mecA, mecC, norA, norC, MgrA, tet(45), APH(3′)-IIIa, ermC, AAC(6′)-APH(2″), and fusC. These genes confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, tetracyclines, aminoglycosides, macrolides, lincosamides, streptogramin B, and fusidic acid.
Evaluation of the synergistic effect of chitosan metal ions (Cu(2+)/Co(2+)) in combination with antibiotics to counteract the effects on antibiotic resistant bacteria.
The study identifies several antibiotic resistance genes, including mecA, blaz, pbp-4, pbp-1, blaTEM, blaCMY, and blaSHV, which are involved in resistance to penicillin in Staphylococcus aureus and Escherichia coli. These genes show reduced expression when treated with chitosan-metal ion nanoparticles in combination with antibiotics.
Clonal dissemination of successful emerging clone mecA-MRSA t304/ST6 among humans and hedgehogs in the Helsinki metropolitan area in Finland.
The study identifies the clonal dissemination of mecA-MRSA t304/ST6 among humans and hedgehogs in the Helsinki metropolitan area, highlighting the potential for spillback of human-adapted MRSA strains to wildlife.
Methicillin-Resistant Staphylococcus aureus Strains Isolated from Burned Patients in a Tunisian Hospital: Molecular Typing, Virulence Genes, and Antimicrobial Resistance.
The study identified several AMR genes in MRSA isolates from burned patients, including blaZ, erm(C), msr(A), and tet(M), which confer resistance to penicillin, erythromycin, and tetracycline.
Molecular Characterization of Staphylococcus aureus Isolated from Raw Milk and Humans in Eastern Tanzania: Genetic Diversity and Inter-Host Transmission.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from raw milk and humans in eastern Tanzania, including blaZ, dfrG, erm(C), tet(K), and str, which confer resistance to penicillin, trimethoprim, macrolides, tetracycline, and streptomycin, respectively.
Occurrence of antimicrobial-resistant Staphylococcus aureus in a Brazilian veterinary hospital environment.
The study identified several AMR genes in Staphylococcus aureus isolates from a Brazilian veterinary hospital, including blaZ, mecA, norA, norC, tetM, tet38, ermA, and ermB, which confer resistance to various antibiotics such as penicillin, methicillin, tetracycline, and erythromycin.
Prevalence and antibiotic resistance of Staphylococcus aureus associated with a college-aged cohort: life-style factors that contribute to nasal carriage.
The study identified several AMR genes in S. aureus isolates, including blaZ, mecA, tetM, dfrS1, ermA, ermC, msrA, and norA, which conferred resistance to penicillin, cefoxitin, tetracycline, trimethoprim, azithromycin, and ciprofloxacin.
Antimicrobial resistance and virulence profiles of staphylococci isolated from clinical bovine mastitis.
The study identified several AMR genes including blaZ, mecA, tetK, tetM, ermC, and ermB in Staphylococcus aureus and coagulase-negative staphylococci isolated from bovine mastitis. These genes conferred resistance to penicillin, methicillin, tetracycline, and erythromycin.
The Prevalence of the Virulence Genes of Staphylococcus aureus in Sickle Cell Disease Patients at KSUMC, Riyadh, Saudi Arabia.
The study identified the presence of several virulence genes and antibiotic resistance genes in clinical Staphylococcus aureus and MRSA isolates from SCD patients, including blaZ, mecA, tetK, and ermC.
Occurrence, Antibiotic Susceptibility, Biofilm Formation and Molecular Characterization of Staphylococcus aureus Isolated from Raw Shrimp in China.
The study identified multiple antibiotic resistance genes in Staphylococcus aureus isolates from raw shrimp in China, including mecA, mecR1, blaZ, aph(3')-IIIa, aad(6), ANT(4')-Ib, tet(K), mph(C), lnu(A), ermB, ermC, dfrC, dfrG, fosB, SAT-4, rpoB, msr(A), mepA, mepR, norA, mgrA, tet(38), sav1866, arlR, and arlS, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, macrolides, lincosamides, streptogramins, trimethoprim, fosfomycin, and others.
Elucidation of the Bovine Intramammary Bacteriome and Resistome from healthy cows of Swiss dairy farms in the Canton Tessin.
The study identified the presence of the tetracycline resistance gene tetK in Mammaliicoccus sciuri isolates, which was associated with tetracycline resistance. The gene was found on small plasmids, suggesting a potential mechanism for horizontal gene transfer.
Whole-Genome Sequencing-Based Screening of MRSA in Patients and Healthcare Workers in Public Hospitals in Benin.
The study identified multiple AMR genes and mutations in MRSA isolates from Benin, including mecA, aac(6')-Ie/aph(2")-Ia, aph(3')-IIIa, blaI, blaR1, blaZ, mecI, mecR1, fosB, erm(C), mph(C), msr(A), qacC, dfrG, and dfrS1, along with mutations in glpT, murA, gyrA, and parC associated with resistance to various antibiotics.
Antimicrobial susceptibility of staphylococci from bovine milk samples in routine microbiological mastitis analysis in Finland.
The study identified blaZ as a gene conferring penicillin resistance in staphylococci from bovine milk samples. mecA was found in some non-aureus staphylococci, contributing to methicillin resistance.
Whole genome sequence-based analysis of Staphylococcus aureus isolated from bovine mastitis in Thuringia, Germany.
The study identified multiple AMR genes and mutations in Staphylococcus aureus isolates from bovine mastitis in Thuringia, Germany, including blaZ, blaI, blaR, blaPC, mecA, tetM, tetK, ermA, dfrG, dfrK, ant(6)-Ia, aac(6')-Ie-aph(2"), aadD1, ant(9)-Ia, ant(4')-Ia, aph(2")-Ih, gyrA_S84L, and parC_S80F/Y.
Genetic and Phenotypic Characterization of Subclinical Mastitis-Causing Multidrug-Resistant Staphylococcus aureus.
The study identified blaZ, norA, norC, tet38, and icaD genes in multidrug-resistant Staphylococcus aureus isolates associated with subclinical mastitis. These genes were linked to resistance against penicillin, tetracycline, macrolides, fluoroquinolones, and biofilm formation.
Potential of Natural Phenolic Compounds as Antimicrobial Agents against Multidrug-Resistant Staphylococcus aureus in Chicken Meat.
The study identified several antimicrobial resistance genes in multidrug-resistant Staphylococcus aureus isolates from chicken meat, including aacA-aphD, blaZ, mecA, apmA, and vanA. These genes were experimentally validated and associated with resistance to various antibiotics.
Sub-MIC streptomycin and tetracycline enhanced Staphylococcus aureus Guangzhou-SAU749 biofilm formation, an in-depth study on transcriptomics.
The study identified several AMR genes in S. aureus Guangzhou-SAU749, including ermB, mecA, mecR1, mepA, aad(6), tet(38), and others. These genes were associated with resistance to various antibiotics. Additionally, the study found that sub-MIC concentrations of streptomycin and tetracycline enhanced biofilm formation, which was linked to the regulation of genes such as arlR, hssR, tagA, clfB, and atlA.
Whole genome sequence-based characterization of virulence and antimicrobial resistance gene profiles of Staphylococcus aureus isolated from food poisoning incidents in eastern China.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from food poisoning incidents in Eastern China, including blaZ, aadD1, mecA, ermB, and tetM, which confer resistance to penicillin, gentamicin, methicillin, erythromycin, and tetracycline, respectively.
Antimicrobial resistance profiles of salmonella spp. and escherichia coli isolated from fresh nile tilapia (oreochromis niloticus) fish marketed for human consumption.
The study identified various antimicrobial resistance genes in Salmonella spp. and E. coli isolates from Nile tilapia, including beta-lactamases, tetracycline, sulfonamide, trimethoprim, and aminoglycoside resistance genes, indicating the presence of multidrug-resistant strains.
Multidrug Resistance in Enterococci Isolated from Cheese and Capable of Producing Benzalkonium Chloride-Resistant Biofilms.
The study identified vancomycin resistance genes (vanA), erythromycin resistance genes (ermC), beta-lactam resistance gene (pbp5), aminoglycoside resistance gene (aac(6')-Ie-aph(2'')-Ia), and penicillin resistance gene (blaZ) in Enterococcus isolates from cheese. These isolates also showed multidrug resistance and biofilm formation capabilities.
Epidemiology and impact of methicillin-sensitive Staphylococcus aureus with β-lactam antibiotic inoculum effects in adults with cystic fibrosis.
The study identifies blaZ as a gene responsible for β-lactam antibiotic inoculum effects in methicillin-sensitive Staphylococcus aureus (MSSA) isolates from cystic fibrosis (CF) patients, particularly associated with reduced susceptibility to cefazolin and piperacillin-tazobactam.
Investigation of antimicrobial susceptibility and genetic diversity among Staphylococcus pseudintermedius isolated from dogs in Rio de Janeiro.
The study identified 21 resistance determinants in MRSP and MSSP strains of Staphylococcus pseudintermedius, including genes such as blaZ, sdrM, norA, fosB, ykkcd, sepA, aac(6')-aph(2''), dfrG, aph(3')-III, ant(6)-Ia, sat4, erm(B), aad(6), tet(M), cat(pC221), qacG, tet(K), and qacJ, which confer resistance to various antimicrobials.
Fatal bacteremia caused by Staphylococcus argenteus: A case report.
The case report describes a fatal bacteremia caused by Staphylococcus argenteus, which was found to be resistant to benzylpenicillin due to the presence of the blaZ gene encoding a beta-lactamase.
Antimicrobial Resistance Profiles of Staphylococcus Isolated from Cows with Subclinical Mastitis: Do Strains from the Environment and from Humans Contribute to the Dissemination of Resistance among Bacteria on Dairy Farms in Colombia?
The study identified several AMR genes in Staphylococcus isolates from dairy farms in Colombia, including blaZ, aacA-aphD, mecA, tetK, and ermC, which confer resistance to β-lactams, aminoglycosides, methicillin, tetracyclines, and macrolides, respectively.
Occurrence and Antimicrobial Resistance among Staphylococci Isolated from the Skin Microbiota of Healthy Goats and Sheep.
The study identified several antimicrobial resistance genes in staphylococci isolated from the skin microbiota of healthy goats and sheep, including mecA, blaZ, tetL, tetK, ermB, ermC, lnu, and grlA. These genes confer resistance to various antibiotics such as methicillin, penicillin, tetracycline, macrolides, lincosamides, and fluoroquinolones.
Molecular characteristics of Staphylococcus aureus strains isolated from subclinical mastitis of water buffaloes in Guangdong Province, China.
The study identified several AMR genes in S. aureus isolates from subclinical mastitis in water buffaloes, including tetM, msrB, blaZ, mecA, and fexA. These genes conferred resistance to tetracycline, erythromycin, penicillin, cefoxitin, and florfenicol, respectively.
Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance of Staphylococcus saprophyticus.
The study identifies several AMR genes in Staphylococcus saprophyticus, including mecA, blaZ, erm, erm(44)v, msr(A), and mph(C), which confer resistance to beta-lactams, macrolides, and lincosamides. The presence of these genes is associated with varying levels of resistance, and some genes, like mecA, are useful markers for predicting resistance to specific antibiotics.
Antibiotic Resistance Genes, Virulence Factors, and Biofilm Formation in Coagulase-Negative Staphylococcus spp. Isolates from European Hakes (Merluccius merluccius, L.) Caught in the Northeast Atlantic Ocean.
The study identifies multiple antibiotic resistance genes in coagulase-negative staphylococci (CoNS) isolated from European hakes, including blaZ, mphC, msr(A/B), lnuA, vgaA, fusB, and dfrA, which confer resistance to penicillin, macrolides/lincosamides, fusidic acid, and trimethoprim-sulfamethoxazole. These CoNS isolates also carry virulence factors such as scn and hla.
Canine Staphylococcaceae circulating in a Kenyan animal shelter.
The study identified various AMR genes in Staphylococcaceae strains isolated from dogs in a Kenyan animal shelter, including tetracycline, beta-lactam, and aminoglycoside resistance genes.
Prevalence, antibiotic resistance and molecular characterization of Staphylococcus aureus in ready-to-eat fruits and vegetables in Shanghai, China.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from ready-to-eat fruits and vegetables in Shanghai, China, including genes conferring resistance to beta-lactams, fluoroquinolones, aminoglycosides, lincosamides, and fosfomycin.
Unveiling the Relationship between Ceftobiprole and High-Molecular-Mass (HMM) Penicillin-Binding Proteins (PBPs) in Enterococcus faecalis.
The study identifies mutations in the pbp4 gene (del A and T418A) associated with reduced susceptibility to β-lactams, including BPR, in Enterococcus faecalis. Additionally, the presence of the blaZ gene was confirmed in certain strains, contributing to β-lactam resistance.
Beyond the Wild MRSA: Genetic Features and Phylogenomic Review of mecC-Mediated Methicillin Resistance in Non-aureus Staphylococci and Mammaliicocci.
The study identifies the mecC gene as a key mediator of methicillin resistance in non-aureus staphylococci and mammaliicocci, highlighting its prevalence in various species and its association with multidrug resistance. The genetic environment of mecC is found to vary significantly, with some strains carrying hybrid SCC mec-mecC elements.
Comparative genomic analysis of antibiotic resistance and virulence genes in Staphylococcus aureus isolates from patients and retail meat.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from both patients and retail meat, including blaZ, fosB-Saur, tet38, mphC, msrA, sat4, mecA, aph(3')-IIIa, and fusC. These genes were associated with resistance to various antibiotics such as penicillin, tetracycline, macrolides, and fusidic acid.
Molecular identification and whole genome sequence analyses of methicillin-resistant and mastitis-associated Staphylococcus aureus sequence types 6 and 2454 isolated from dairy cows.
The study identified methicillin-resistant Staphylococcus aureus strains BR-MHR220 and BR-MHR281, with BR-MHR220 harboring the mecA and blaZ genes, indicating resistance to methicillin, cefoxitin, oxacillin, and penicillin G. BR-MHR281 showed no antibiotic resistance genes but exhibited resistance to gentamicin and levofloxacin.
Virulence determinants and antibiotic resistance in staphylococci isolated from the skin of captive bred reptiles.
The study identified several AMR genes in staphylococci isolated from the skin of captive-bred reptiles, including blaZ, dfrK, dfrA(S1), tetK, msrA, mecA, and mecC. These genes conferred resistance to various antibiotics such as ampicillin, cefoxitin, trimethoprim, tetracycline, erythromycin, and cephalosporins. The study highlights the prevalence of multidrug resistance among these isolates.
Prevalence of virulence- and antibiotic resistance-associated genotypes and phenotypes in Staphylococcus aureus strains from the food sector compared to clinical and cow mastitis isolates.
The study identified various antibiotic resistance genes and mutations in Staphylococcus aureus strains from different sources, including beta-lactam resistance genes (blaZ, mecA), aminoglycoside resistance genes (ant(4')-Ia, aph(3')-Ia), tetracycline resistance genes (tetM, tetK), and the bleO gene for bleomycin resistance. Mutations in gyrA and grlA were also found to contribute to quinolone resistance.
Resistome, mobilome, and virulome explored in clinical isolates derived from acne patients in Egypt: unveiling unique traits of an emerging coagulase-negative Staphylococcus pathogen.
The study identified multiple antibiotic resistance genes in coagulase-negative staphylococci (CoNS) isolates from acne patients in Egypt, including blaZ, mecA, tet(K), erm(C), lnuA, vgaA, dfrC, fusB, fosBx1, norA, and vanT. These genes were found to be located on plasmids and chromosomes, indicating a multidrug-resistant profile.
Genomic epidemiology of the primary methicillin-resistant Staphylococcus aureus clones causing invasive infections in Paraguayan children.
The study identified several AMR genes in MRSA isolates causing invasive infections in Paraguayan children, including mecA, blaZ, ermC, aac(6')-aph(2"), tet(38), cat(pC221), fos-B-Saur, and rphC, which confer resistance to various antibiotics such as methicillin, penicillin, erythromycin, clindamycin, gentamicin, tetracycline, chloramphenicol, and rifampin.
Genetic Diversification and Resistome of Coagulase-Negative Staphylococci from Nostrils of Healthy Dogs and Dog-Owners in La Rioja, Spain.
The study identified various AMR genes including blaZ, mecA, erm(A), erm(C), erm(T), mph(C), msr(A), vga(A), lsaB, ant4′, aac6′-aph2″, tet(K), tet(M), dfrA, dfrG, catPC221, and mupA in CoNS isolates from healthy dogs and dog-owners. Additionally, a linezolid-resistant S. epidermidis isolate was found to have multiple amino acid substitutions in 50S ribosomal proteins L3 and L4.
Novel synergistic interactions between monolaurin, a mono-acyl glycerol and β lactam antibiotics against Staphylococcus aureus: an in vitro study.
The study identified the blaZ gene encoding a beta-lactamase responsible for resistance to ampicillin, amoxicillin, and piperacillin in Staphylococcus aureus. Monolaurin was shown to reduce the expression of blaZ, enhancing the efficacy of β-lactam antibiotics.
Hybrid Illumina-Nanopore assembly improves identification of multilocus sequence types and antimicrobial resistance genes of Staphylococcus aureus isolated from Vermont dairy farms: comparison to Illumina-only and R9.4.1 nanopore-only assemblies.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from Vermont dairy farms, including beta-lactam resistance genes (blaZ, blaI, blaR), tetracycline resistance genes (tet(K), tet(38)), erythromycin resistance genes (erm(T), erm(A)), lincomycin resistance gene (lnu(G)), aminoglycoside resistance genes (aaC3, ant(9)-la), multidrug resistance efflux pumps (lmrS, mepA, mepR, mepB, norA, norB, arlS, arlR, mgrA), and fosfomycin resistance gene (fosB).
Hybrid Illumina-Nanopore assembly improves identification of multilocus sequence types and antimicrobial resistance genes of Staphylococcus aureus isolated from Vermont dairy farms: comparison to Illumina-only and R9.4.1 nanopore-only assemblies.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from Vermont dairy farms, including beta-lactam resistance genes (blaZ, blaI, blaR), tetracycline resistance genes (tet(K), tet(38)), erythromycin resistance genes (erm(T), erm(A)), lincomycin resistance gene (lnu(G)), aminoglycoside resistance genes (aaC3, ant(9)-la), multidrug resistance efflux pumps (lmrS, mepA, mepR, mepB, norA, norB, arlS, arlR, mgrA), and fosfomycin resistance gene (fosB).
Green Synthesized Chitosan Nanoparticles for Controlling Multidrug-Resistant mecA- and blaZ-Positive Staphylococcus aureus and aadA1-Positive Escherichia coli.
The study identifies mecA, blaZ, and aadA1 as resistance genes in multidrug-resistant Staphylococcus aureus and Escherichia coli, demonstrating the efficacy of chitosan nanoparticles against these pathogens.
Molecular detection of multidrug and methicillin resistance in Staphylococcus aureus isolated from wild pigeons (Columba livia) in South Africa.
The study identified multiple antibiotic resistance genes, including mecA, tetM, aac(6')-aph(2"), ermC, and blaZ, in Staphylococcus aureus isolates from wild pigeons in South Africa, highlighting the presence of multidrug-resistant and methicillin-resistant S. aureus in the environment.
Alarming multidrug resistance in Staphylococcus aureus isolated from raw milk of cows with subclinical mastitis: Antibiotic resistance patterns and occurrence of selected resistance genes.
The study identified the presence of multidrug-resistant Staphylococcus aureus (MDR-S. aureus) and methicillin-resistant S. aureus (MRSA) strains in raw milk from cows with subclinical mastitis, carrying resistance genes blaZ, tetK, mecA, and aacA-aphD.
Methicillin-resistant Staphylococcus aureus and coagulase-negative Staphylococcus produce antimicrobial substances against members of the skin microbiota in children with atopic dermatitis.
The study identified two bacteriocin gene clusters, aureocin 4181 in MRSA 23ad and epidermicin NI01 in S. epidermidis 84ad, which are involved in the production of antimicrobial substances that inhibit the growth of other staphylococcal species.
Antimicrobial resistance, enterotoxin and biofilm production genes in Staphylococcus spp. isolated from facilities and fomites in veterinary hospital in the Caatinga biome.
The study identified several antimicrobial resistance genes including blaZ, mecA, tetM, tetL, and tetK in Staphylococcus spp. isolates from a veterinary hospital in the Caatinga biome. Additionally, the icaD gene associated with biofilm production was detected in one S. sciuri strain.
Genetic and Phenotypic Changes Related to the Development of mec-Independent Oxacillin Non-Susceptibility in ST8 Staphylococcus aureus Recovered after Antibiotic Therapy in a Patient with Bacteremia.
The study identifies a mec-independent oxacillin non-susceptible S. aureus strain (SA2) with a PBP2 Ala450Asp mutation contributing to oxacillin resistance and reduced teicoplanin susceptibility.
Emergence of novel methicillin resistant Staphylococcus pseudintermedius lineages revealed by whole genome sequencing of isolates from companion animals and humans in Scotland.
The study identified novel methicillin-resistant Staphylococcus pseudintermedius (MRSP) lineages, including ST726 and ST551, and characterized antimicrobial resistance genes such as mecA, blaZ, tetK, and mupA. It also noted a high prevalence of multidrug resistance (MDR) among MRSP isolates.
Mobile genetic element-driven genomic changes in a community-associated methicillin-resistant Staphylococcus aureus clone during its transmission in a regional community outbreak in Japan.
The study identified the blaZ gene as a determinant of penicillin resistance in the TDC clone of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) during a regional outbreak in Japan.
Staphylococcus aureus associated with surgical site infections in Western Kenya reveals genomic hotspots for pathogen evolution.
The study identifies blaZ as a beta-lactam resistance gene in ST152 S. aureus isolates and detects mutations in MurA, GyrA, and ParC that confer resistance to fosfomycin and fluoroquinolones.
Investigation of antimicrobial resistance and antimicrobial resistance genes in Staphylococcus aureus and coagulase-negative staphylococci isolated from rabbit.
The study identified multiple antimicrobial resistance genes, including bla Z, aac A- aph D, msr A, tet K, gyr A, grl A, dfr G, and cfr, in Staphylococcus aureus and coagulase-negative staphylococci isolated from rabbit clinical abscesses, highlighting the presence of multidrug-resistant strains.
Genomic analysis of Staphylococcus aureus isolates from bacteremia reveals genetic features associated with the COVID-19 pandemic.
The study identifies several antibiotic resistance genes and mutations in Staphylococcus aureus isolates associated with increased resistance to methicillin, macrolides, and other antibiotics during the COVID-19 pandemic.
High toxinogenic potential of Staphylococcus aureus from wild ungulates in Brandenburg, Germany with a low level of antibiotic resistance.
The study identified the blaZ gene conferring resistance to penicillin and cefoxitin in a Staphylococcus aureus isolate, and the fosB gene associated with fosfomycin resistance in four isolates.
Genomic characterization of methicillin-resistant Staphylococcus aureus isolated from patients attending regional referral hospitals in Tanzania.
The study identifies the presence of various AMR genes in MRSA isolates from Tanzanian regional hospitals, including blaZ, erm(C), aac(6')-aph(2''), and tet(K). These genes contribute to resistance against beta-lactams, macrolides, aminoglycosides, and tetracyclines, highlighting the complexity of resistance profiles in MRSA.
Emergence of Staphylococcus argenteus in pediatrics: Molecular insights from a hospital in East China.
The study identified six antibiotic-resistance genes in the S. argenteus strain 22WJ8192, including blaZ, blaI_of_Z, blaR1, aph(3')-IIIa, tet(38), and fosB-Saur, which conferred resistance to penicillin, amikacin, tetracycline, and fosfomycin. These genes were found to be more prevalent in human-origin strains compared to nonhuman-origin strains.
Prevalence of pathogens and antimicrobial resistance of isolated Staphylococcus spp. in bovine mastitis milk in South Korea, 2018-2022.
The study identified several antimicrobial resistance genes in Staphylococcus spp. isolated from bovine mastitis milk, including mecA, blaZ, tetK, ermC, lnuA, and lnuB. These genes were associated with resistance to penicillins, tetracyclines, erythromycin, and lincomycin.
Desiccation tolerance and reduced antibiotic resistance: Key drivers in ST239-III to ST22-IV MRSA clonal replacement at a Malaysian teaching hospital.
The study identifies AMR genes and mutations associated with the clonal replacement of MRSA strains in a Malaysian hospital, highlighting the role of desiccation tolerance and reduced antibiotic resistance.
Evaluation of the QIAstat-Dx BCID GN and GPF kits for direct identification and antimicrobial resistance prediction from blood culture bottles.
The QIAstat-Dx BCID GN and GPF kits showed high accuracy in detecting AMR genes such as blaZ, mecA, ermC, aac(6')-lb, ctx-m, ampC, shv, tem, tetM, and aac(6')/aph(2") in various bacteria, correlating well with phenotypic resistance results.
Altered genomic methylation promotes Staphylococcus aureus persistence in hospital environment.
The study identifies the aacA-aphD gene as a contributor to gentamicin resistance in a hospital-adapted Staphylococcus aureus lineage, highlighting the role of genomic methylation in regulating Agr expression and bacterial persistence.
Coexistence of the blaZ gene and selected virulence determinants in multidrug-resistant Staphylococcus aureus: insights from three Nigerian tertiary hospitals.
The study identifies the blaZ gene as a major contributor to β-lactam resistance in multidrug-resistant Staphylococcus aureus isolates, along with the presence of virulence factors such as PVL, cap5, cap8, and agr2.
Detection and genetic characterization of multidrug-resistant staphylococci isolated from public areas in an international airport.
The study identified multiple multidrug-resistant staphylococci, including methicillin-resistant S. haemolyticus, S. epidermidis, and a livestock-associated MRSA (LA-MRSA) strain, carrying various resistance genes such as mecA, blaZ, erm(C), aac(6')-aph(2''), and others, highlighting the presence of AMR in public environments.
Deciphering the genomic character of the multidrug-resistant Staphylococcus aureus from Dhaka, Bangladesh.
The study identified multiple AMR genes in multidrug-resistant S. aureus isolates from Bangladesh, including mecA, blaZ, ermC, mepA, norA, norC, sdrM, and lmrS, which confer resistance to various antibiotics.
Zoonotic transmission of asymptomatic carriage Staphylococcus aureus on dairy farms in Canterbury, New Zealand.
The study identified a bovine isolate carrying the extended-spectrum beta-lactamase gene blaTEM-116, highlighting concerns about antimicrobial resistance in dairy farm environments. Multiple antimicrobial resistance genes were detected in both bovine and human isolates, including genes conferring resistance to tetracyclines, penicillins, fosfomycin, and aminoglycosides.
Zoonotic transmission of asymptomatic carriage Staphylococcus aureus on dairy farms in Canterbury, New Zealand.
The study identified a bovine isolate carrying the extended-spectrum beta-lactamase gene blaTEM-116, highlighting concerns about antimicrobial resistance in dairy farm environments. Multiple antimicrobial resistance genes were detected in both bovine and human isolates, including genes conferring resistance to tetracyclines, penicillins, fosfomycin, and aminoglycosides.
NaHCO3 modulates the bla operon and β-lactam susceptibility in borderline oxacillin-resistant Staphylococcus aureus (BORSA).
NaHCO3 modulates the bla operon, reducing beta-lactamase production and enhancing susceptibility to penicillin and ampicillin in BORSA strains.
β-Lactam Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus Infective Endocarditis.
The study identifies blaZ as a gene that confers resistance to β-lactam antibiotics, and the presence of an inoculum effect in blaZ-positive strains is associated with increased mortality in methicillin-susceptible Staphylococcus aureus infective endocarditis.
Can α-Mangostin and Photodynamic Therapy Support Ciprofloxacin in the Inactivation of Uropathogenic Escherichia coli and Staphylococcus aureus Strains?
The study identified several antibiotic resistance genes in clinical strains of Staphylococcus aureus and Escherichia coli, including blaZ, grlA, grlB, gyrA, mecA, ermC, aph(6)-Id, aph(3")-Ib, aadA5, blaCTX-M-27, mph(A), sul1, sul2, tet(A), and dfrA17. These genes confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, aminoglycosides, sulfonamides, tetracyclines, and macrolides.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Mapping Antimicrobial Resistance in Staphylococcus epidermidis Isolates from Subclinical Mastitis in Danish Dairy Cows.
The study identified several antimicrobial resistance genes in Staphylococcus epidermidis isolates from subclinical mastitis in Danish dairy cows, including blaZ for penicillin resistance, fosB for fosfomycin resistance, msr(A) and mph(C) for erythromycin resistance, and tet(K) for tetracycline resistance.
Whole-genome analysis of a ST45-SCCmec IVa (2B)-t116 methicillin-resistant Staphylococcus aureus strain isolated from the sputum of a 5-year-old child with pneumonia.
The study identified the presence of the mecA and blaZ genes in the ST45-SCCmec IVa (2B)-t116 MRSA strain SA2107, which confer resistance to methicillin and penicillin, respectively.
Staphylococcus epidermidis: Antimicrobial Resistance Profiles of Biofilm-Forming Isolates From Pediatric Bacteremia in Pakistan.
The study identified mecA, msrA, and blaZ genes in biofilm-forming Staphylococcus epidermidis isolates from pediatric bacteremia, showing high prevalence of methicillin, erythromycin, and beta-lactam resistance.
Characteristic profiles of molecular types, antibiotic resistance, antibiotic resistance genes, and virulence genes of Staphylococcus aureus isolates from caprine mastitis in China.
The study identified several AMR genes in S. aureus isolates from caprine mastitis in China, including blaZ, mecA, tetK, tetM, ermB, lnu(B), aacA-aphD, and gyrA, which confer resistance to various antibiotics such as penicillin, oxacillin, tetracycline, erythromycin, lincomycin, gentamicin, amikacin, and fluoroquinolones.
Genotypic profile of Staphylococcus spp., Enterococcus spp., and E. coli colonizing dogs, surgeons, and environment during the intraoperative period: a cross-sectional study in a veterinary teaching hospital in Brazil.
The study identified resistance genes blaZ, mecA, tet(M), and aacA-aphD in Staphylococcus spp. and Enterococcus spp. isolates, indicating high rates of methicillin-resistant Staphylococcus spp. and tetracycline-resistant Enterococcus spp. in a veterinary teaching hospital setting.
Comparison of Staphylococcus pettenkoferi Isolated from Human Clinical Cases and Cat Carriers Regarding Antibiotic Susceptibility and Biofilm Production.
The study identified several AMR genes in Staphylococcus pettenkoferi isolates from human and feline sources, including blaZ, mecA, ermA, tet(L), vanA, aph3-IIIa, ter(M), mupA, and fusB, which confer resistance to various antibiotics such as penicillins, methicillin, erythromycin, tetracyclines, vancomycin, gentamicin, mupirocin, and fusidic acid.
Study on molecular characteristics of Staphylococcus from yak milk-Xizang.
The study identified several AMR genes in Staphylococcus isolates from yak milk, including blaZ, mecA, gyrA, glrB, gyrB, lnuA, tetK, aacA-aphD, vga, and ermC, which confer resistance to various antibiotics such as penicillin, methicillin, tetracycline, and aminoglycosides.
Molecular characterization and antimicrobial-resistance gene profile of Staphylococcus aureus strains isolated from ovine mastitis in Jordan.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from ovine mastitis in Jordan, including blaZ, aph(3')-III, ant(4')-Ia, str, and mecA. These genes conferred resistance to penicillin G, kanamycin, streptomycin, and methicillin.
Prevalence, virulence factors, and antibiotic resistance of Staphylococcus aureus in seafood products.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolated from seafood products, including blaZ, mecA, tetM, and ermA. These genes were associated with resistance to penicillin G, ampicillin, tetracycline, and erythromycin, respectively.
Prevalence of Variant GTR(I)Staphylococcus aureus Isolated from Dairy Cow Milk Samples in the Alpine Grazing System of the Aosta Valley and Its Association with AMR and Virulence Profiles.
The study identified the blaZ gene as a key determinant of penicillin resistance in Staphylococcus aureus isolates from dairy cows in the Aosta Valley, with high prevalence in the CLR genotypic cluster.
Identification of Novel Staphylococcus aureus Core and Accessory Virulence Patterns in Chronic Rhinosinusitis.
The study identifies various antimicrobial resistance genes in Staphylococcus aureus isolates from patients with chronic rhinosinusitis, including blaI, blaZ, blaPC1, blaR1, erm(T), erm(A), tet(38), mepA, fosB, and ermC, which confer resistance to penicillin, macrolides, lincosamides, streptogramins, tetracycline, and fosfomycin.
Identification of Novel Staphylococcus aureus Core and Accessory Virulence Patterns in Chronic Rhinosinusitis.
The study identifies various antimicrobial resistance genes in Staphylococcus aureus isolates from patients with chronic rhinosinusitis, including blaI, blaZ, blaPC1, blaR1, erm(T), erm(A), tet(38), mepA, fosB, and ermC, which confer resistance to penicillin, macrolides, lincosamides, streptogramins, tetracycline, and fosfomycin.
Genetic Variation in the blaZ Gene Leading to the BORSA Phenotype in Staphylococcus aureus.
The study identifies a novel blaZ variant F in Staphylococcus aureus that leads to the BORSA phenotype, characterized by increased resistance to beta-lactam antibiotics such as benzylpenicillin, cloxacillin, and oxacillin. Variant F shows enhanced beta-lactamase activity compared to existing variants A, B, C, and D.
Antimicrobial Resistant Staphylococcus spp., Escherichia coli, and Salmonella spp. in Food Handlers: A Global Review of Persistence, Transmission, and Mitigation Challenges.
The study highlights the prevalence of antimicrobial resistance in Staphylococcus spp., Escherichia coli, and Salmonella spp. isolated from food handlers, emphasizing the role of genes such as mecA, blaZ, msrA, linA, and fusB in conferring resistance to various antibiotics.
Skin Infections Caused by Panton-Valentine Leukocidin and Methicillin-Susceptible Staphylococcus aureus in Child, Japan.
The study identified the presence of the beta-lactam resistance gene blaZ, the macrolide resistance gene erm(A), and the aminoglycoside resistance gene ant(9)-Ia in the MSSA ST2233 strain causing recurrent skin infections in a child. Additionally, mutations in the GrlA and GyrA genes were detected, contributing to fluoroquinolone resistance.
Multidrug-Resistant Staphylococcus aureus in Diabetic Foot Infections (DFI) from Beira, Mozambique: Prevalence and Virulence Profile.
The study identified high levels of multidrug resistance in Staphylococcus aureus isolates from diabetic foot infections in Beira, Mozambique, with resistance genes blaZ, mecA, vancA, vancB, ermB, ermC, dfrA, and dfrG being prevalent.
Staphylococcus haemolyticus is a reservoir of antibiotic resistance genes in the preterm infant gut.
The study identifies aacA-aphD, blaZ, and mecA as key antibiotic resistance genes in Staphylococcus haemolyticus isolates from preterm infants, with strong associations to resistance against gentamicin and oxacillin.
Phenotypic and Genotypic Characterization of ESBL and AmpC beta-lactamase-Producing E. coli Isolates from Poultry in Northwestern Romania.
The study identified the presence of ESBL and AmpC beta-lactamase-producing E. coli isolates from poultry in northwestern Romania, highlighting the prevalence of resistance genes blaTEM, blaZ, and AmpC, which contribute to resistance against β-lactam antibiotics.
Comparative genomic analysis of resistance and virulence genes in staphylococcus epidermidis and their impact on clinical outcome of musculoskeletal infections.
The study identified mecA, blaZ, IS256, and icaADBC as key genes associated with resistance and virulence in Staphylococcus epidermidis isolates from musculoskeletal infections. Mutations in parE (D432V) and rpoB (H481N, I527M) were linked to quinolone and rifampicin resistance, respectively.
Emergence of livestock-associated MRSA in the Egyptian Nile Delta that carry the exfoliative toxin gene etA: a case for enhanced surveillance.
The study identifies a novel variant of a CC15 livestock-associated MRSA strain from Egypt that carries the exfoliative toxin gene etA, highlighting potential increased virulence and the need for enhanced surveillance.
Study of lug Operon, SCCmec Elements, Antimicrobial Resistance, MGEs, and STs of Staphylococcus lugdunensis Clinical Isolates Through Whole-Genome Sequencing.
The study identified several AMR genes, including mecA, blaZ, erm(A), aac(6')-aph(2"), aph(3')-III, ant(9)-Ia, and dfrG, in S. lugdunensis isolates, which conferred resistance to various antibiotics such as penicillins, oxacillin, erythromycin, clindamycin, aminoglycosides, and trimethoprim-sulfamethoxazole.
Adaptive laboratory-evolved MRSA with PPEF manifests cross-susceptibility to oxacillin and hypersensitivity to ciprofloxacin.
The study identifies the downregulation of several AMR genes, including blaZ, mecR1, kdpB, ble, pbp, and ermA, in PPEF-evolved MRSA-PR strains, leading to increased susceptibility to antibiotics such as oxacillin, ciprofloxacin, gentamicin, and imipenem.
Prevalence and antimicrobial resistance of methicillin-resistant and methicillin-susceptible Staphylococcus in small- to medium-scale and large-scale dairy farms in Thailand.
The study identified several AMR genes and mutations in Staphylococcus isolates from small- to medium-scale and large-scale dairy farms in Thailand, highlighting differences in resistance profiles between farm types.
Antimicrobial-Resistant Staphylococcus spp. Harbored by Hedgehogs (Erinaceus europaeus) in Central Italy.
The study identified the presence of antimicrobial-resistant Staphylococcus spp. in hedgehogs, including the detection of the blaZ and mecA genes associated with beta-lactam resistance. Vancomycin-resistant strains were also found, but they lacked the vanA and vanB genes.
Characteristics of Staphylococcus saprophyticus Isolated from Humans and Animals.
The study identified several AMR genes in Staphylococcus saprophyticus strains isolated from humans and animals, including blaZ, mecA, ermA, ermB, tetM, fusB, and mupA, which confer resistance to various antibiotics such as beta-lactams, macrolides, tetracyclines, fusidic acid, and mupirocin.
Staphylococcus epidermidis in Acute Myeloid Leukemia: A Comparative Genomic Study Against Non-AML Isolates.
The study identified several AMR genes in S. epidermidis isolates from AML patients, including mecA, mecR1, qacA, ermC, tetM, cfrA, ANT(4′)-Ib, blaZ, dfrG, cat, and mecI, which were associated with increased resistance to various antibiotics.
Antibacterial Activity of Clove Essential Oil (Syzygium aromaticum) Against Oxacillin-Resistant Staphylococcus pseudintermedius Isolated from Dogs with Otitis Externa.
The study identified the presence of mecA and blaZ genes in oxacillin-resistant Staphylococcus pseudintermedius isolates from dogs with otitis externa, highlighting their role in β-lactam resistance. Clove essential oil showed in vitro antimicrobial activity against both resistant and susceptible isolates.
Combatting resistance: natural products as tools to drive the discovery of untapped antibiotic targets.
The paper discusses the mechanisms of antibiotic resistance, focusing on genes such as blaZ, mecA, folP, and sul, which confer resistance to penicillins and sulfonamides. These genes were experimentally validated in the study.
Antimicrobial Activities of Propolis Nanoparticles in Combination with Ampicillin Sodium Against Methicillin-Resistant Staphylococcus aureus.
Propolis nanoparticles (PNPs) in combination with ampicillin sodium (AS) exhibit synergistic antibacterial and anti-biofilm effects against methicillin-resistant Staphylococcus aureus (MRSA) by downregulating the expression of mecA, mecR1, blaZ, and icaADBC genes.
Transposition of Tn552-II (a Tn552 derivative) to the conjugative pCtra plasmid family in pediatric multidrug-resistant community-associated MRSA.
The study reports the transposition of Tn552-II, a transposon carrying the blaZ gene, to the conjugative pCtra plasmid in multidrug-resistant community-associated MRSA, enhancing ampicillin resistance.
Isolation and Molecular Characterization of Three Staphylococcus pseudintermedius Strains from Dogs and Humans in Egypt.
Three Staphylococcus pseudintermedius isolates from dogs and humans in Egypt were characterized. The isolates showed resistance to various antibiotics, including penicillin, tetracycline, aminoglycosides, chloramphenicol, fusidic acid, macrolides, streptothricin, and trimethoprim. None of the isolates carried the mecA gene, which is associated with methicillin resistance.
Phosphorylation of Staphylococcus aureus beta-lactamase, a prerequisite to its sequestration on the cytoplasmic membrane.
The study identifies phosphorylation sites in BlaZ, a beta-lactamase in Staphylococcus aureus, and shows that lipidation is necessary for its phosphorylation and membrane sequestration, contributing to β-lactam resistance.
An NGS-assisted diagnostic workflow for culture-independent detection of bloodstream pathogens and prediction of antimicrobial resistances in sepsis.
The study evaluated the diagnostic performance of PISTE™ technology, an NGS-based workflow for detecting bloodstream pathogens and predicting antimicrobial resistance. It showed high accuracy in identifying pathogens and predicting resistance genes, including beta-lactamases, carbapenemases, aminoglycoside modifying enzymes, tetracycline efflux pumps, and quinolone resistance proteins.
Comprehensive genomic analysis of antibiotic resistance plasmids in animal-associated Staphylococcus aureus in France.
The study identified multiple antibiotic resistance genes in Staphylococcus aureus isolates from animals, including blaZ, str, cat(pC221), tet(M), aac(6')-aph(2'), and dfrK, which were associated with plasmids and contributed to multidrug resistance.
Comparative genomics of endemic Staphylococcus aureus ST1 in New Zealand.
The study identified several AMR genes in Staphylococcus aureus ST1 isolates from New Zealand, including blaZ, tet(38), mecA, mecR1, qacA, qacB, ermC, fusC, mupA, and others. These genes were associated with resistance to various antibiotics such as penicillin, tetracycline, methicillin, quaternary ammonium compounds, erythromycin, fusidic acid, mupirocin, and fluoroquinolones. The study also highlighted the presence of a novel prophage, φSabovST1, in bovine ST1 isolates, which encoded bovine-adapted leukocidins.
Molecular Epidemiology, Antimicrobial Resistance, and Virulence Profiles of Staphylococcus aureus from Fish, Aquatic Environments, and Fish Handlers in Southeast Nigeria.
The study identified 19 antimicrobial resistance genes in Staphylococcus aureus isolates from fish, aquatic environments, and fish handlers in Southeast Nigeria, highlighting the presence of multidrug-resistant strains with various resistance mechanisms.
Contamination and antimicrobial resistance testing of Staphylococcus aureus isolates from pork in the traditional market at Central Vietnam.
The study found that 100% of retail pork samples from traditional markets in Hue City, Vietnam, were contaminated with Staphylococcus aureus. High resistance rates were observed against penicillin, amoxicillin, and tetracycline, with the tetM, blaZ, and femA genes being the most prevalent AMR genes.
Molecular identification of antibiotic-resistant and virulent Escherichia coli and Staphylococcus aureus isolated from dogs in Southern Benin.
The study identified several antibiotic resistance genes in Escherichia coli and Staphylococcus aureus isolated from dogs in Southern Benin, including blaTEM, tetA, strA-strB, tetK, tetM, and blaZ, which confer resistance to penicillin, tetracycline, and streptomycin.
Zoonotic potential of methicillin-resistant Staphylococcus aureus isolated from pets and their owners in Bangladesh.
The study identified methicillin-resistant Staphylococcus aureus (MRSA) in pets and their owners in Bangladesh, highlighting the zoonotic potential of MRSA. Key AMR genes included mecA, tetA, tetK, tet(38), and blaZ, which conferred resistance to methicillin, tetracycline, and penicillin.
A beta-lactamase inhibitory protein mutant displays high potency and a broad inhibition profile due to an altered binding mode with beta-lactamases.
The BLIP E73W mutant exhibits high potency and a broad inhibition profile against class A beta-lactamases, achieved through a distinct binding mode that allows it to inhibit multiple beta-lactamase variants effectively.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
Emergence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus ST398 in Wild Birds, Brazil.
The study reports the first detection of livestock-associated Methicillin-Resistant Staphylococcus aureus ST398 in wild birds in Brazil, highlighting the emergence of antimicrobial-resistant S. aureus in a protected Atlantic Forest fragment. The MRSA isolates exhibited a broad resistome, including genes for resistance to multiple antimicrobial classes.
Antimicrobial resistance and virulence gene patterns of Staphylococcus aureus in infectious mastitis: implications for inflammatory myopathies of the lactating breast.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from lactating patients with infectious mastitis, including aac(6')/aph(2"), blaZ, mecA, aph(3')-III, and qacA/B. These genes were associated with resistance to various antibiotics such as penicillin G, erythromycin, clindamycin, gentamicin, levofloxacin, ciprofloxacin, and tetracycline.
GENETIC DETERMINANTS OF ANTIBIOTIC RESISTANCE AND VIRULENCE IN Staphylococcus aureus ISOLATES FROM HOSPITAL SURFACES IN HIGH-RISK AREAS OF LOJA, ECUADOR.
The study identified the blaZ gene associated with penicillin resistance, mecA for methicillin resistance, and vanA for vancomycin resistance in Staphylococcus aureus isolates from hospital surfaces in Loja, Ecuador.
Molecular epidemiology and geographical variation of methicillin-resistant Staphylococcus aureus: a multicentre study across Xinjiang, China.
The study identified several AMR genes in MRSA isolates from Xinjiang, China, including blaZ, ermB, aph(3')-III, aac(6')-aph(2''), ermC, tetM, and tetK, which confer resistance to various antibiotics such as penicillin, oxacillin, erythromycin, clindamycin, kanamycin, tetracycline, and gentamicin.
Nanopore targeted sequencing in lower respiratory infections: a retrospective study on diagnostic applications, clinical characterization, and antimicrobial guidance.
The study identified 16 distinct AMR genes in 15 patients using NTS, highlighting the effectiveness of NTS in detecting resistance genes in ESKAPE pathogens.
Antimicrobial Resistance in Staphylococcus aureus at the Human-Animal-Environment Interface in East Africa: A Systematic Review and Meta-Analysis
The study identified key resistance genes including mecA, blaZ, tet(K), and erm(C) in Staphylococcus aureus isolates from East Africa, highlighting the prevalence of methicillin-resistant and multidrug-resistant strains.
Distribution of Staphylococcus aureus drug resistance genes, biofilm formation and cell wall characteristics in dairy cattle from dairy farms in Northeast China.
The study identified various antibiotic resistance genes in Staphylococcus aureus isolates from dairy cattle in Northeast China, including tetM, aph(3')-III, ermC, aac(6')/aph(2'), grlB, gyrB, blaZ, and mecA, which confer resistance to tetracycline, aminoglycosides, erythromycin, fluoroquinolones, and beta-lactams.
Effect of surgical antimicrobial prophylaxis duration for colic surgery on complications and resistome.
The study found that extending surgical antimicrobial prophylaxis beyond 24 hours did not increase postoperative complications but led to a higher abundance of beta-lactam resistance genes, including TEM, BlaZ, SHV, CfxA, and PBP2, as well as aminoglycoside-modifying enzymes like AAC(6'), ANT(3"), ANT(6), APH(2"), APH(3'), APH(3"), and APH(6) in the fecal resistome of horses.
Molecular Epidemiology, Clinical Manifestations, Decolonization Strategies, and Treatment Options of Methicillin-Susceptible Staphylococcus Aureus Infection in Neonates.
The study identifies key antimicrobial resistance genes in methicillin-susceptible Staphylococcus aureus (MSSA) isolates, including blaZ, erm(C), and tet(K), which confer resistance to penicillin, macrolides, and tetracycline respectively. These findings highlight the complexity of antimicrobial resistance in MSSA and the need for continued surveillance and tailored antimicrobial stewardship.
Staphylococcus aureus in commercial laying hens from Pernambuco, Brazil: detection of efflux pumps and β-lactam resistance genes.
The study detected β-lactam resistance gene blaZ and methicillin resistance gene mecC, along with efflux pump genes norA, norC, and msrA in Staphylococcus aureus isolates from commercial laying hens in Brazil.
Design, Synthesis, and Evaluation of β‑Lactamase Inhibitors as Potential Therapeutics for Antimicrobial Resistance.
The study identifies compounds 3g and 6a as effective beta-lactamase inhibitors, demonstrating significant inhibition of beta-lactamase activity and synergistic effects when combined with imipenem against clinical isolates of S. aureus.
Emergence of Multidrug-Resistant and Biofilm-Producing Staphylococcus aureus from Raw Poultry in Algeria: Implications for Public Health.
The study identified several AMR genes in S. aureus isolates from raw poultry in Algeria, including blaZ, mecA, tet(M), tet(K), tet(S), erm(B), and erm(C). These genes were associated with resistance to penicillin, methicillin, tetracycline, and erythromycin.
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