Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
class A beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| bla_penA1 | Reslit | 2 | ceftazidime, carbapenems | Burkholderia multivorans ATCC 17616 | - | 2019, 2021 | - | - |
| bla_PenA1 | Reslit | 1 | carbapenems | Burkholderia multivorans +1 | - | 2021 | PDB 3W4Q|PDB 7D5J | - |
"Switching Partners": Piperacillin-Avibactam Is a Highly Potent Combination against Multidrug-Resistant Burkholderia cepacia Complex and Burkholderia gladioli Cystic Fibrosis Isolates.
The study identifies that piperacillin-avibactam effectively restores susceptibility to ceftazidime-avibactam-nonsusceptible Burkholderia cepacia complex and Burkholderia gladioli isolates. It shows that avibactam potently inhibits PenA1, while piperacillin inhibits AmpC1.
Assessing the Potency of β-Lactamase Inhibitors with Diverse Inactivation Mechanisms against the PenA1 Carbapenemase from Burkholderia multivorans.
The study characterizes the PenA1 carbapenemase from Burkholderia multivorans and evaluates the effectiveness of various β-lactamase inhibitors, highlighting the critical role of specific amino acid residues in the inhibition mechanism.
Activity of Imipenem-Relebactam against Multidrug- and Extensively Drug-Resistant Burkholderia cepacia Complex and Burkholderia gladioli.
The study demonstrates that imipenem-relebactam is effective against multidrug-resistant and extensively drug-resistant Burkholderia cepacia complex and Burkholderia gladioli, particularly showing potent activity against ceftazidime-avibactam-resistant isolates. Relebactam effectively inactivates the PenA1 carbapenemase, while imipenem shows some inhibition of AmpC1.
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