Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
extended-spectrum beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaCTX−M−15 | Reslit | 5 | ceftazidime, cefotaxime +9 | Klebsiella pneumoniae +1 | Shanghai, China, South Korea, Egypt, South Africa, United Arab Emirates | 2021, 2022, 2024, 2025 | JAWIZL000000000 | - |
| blactx−M−15 | Reslit | 1 | cefotaxime | Escherichia coli | - | 2025 | - | - |
Drug Susceptibility and Molecular Epidemiology of Klebsiella pneumoniae Bloodstream Infection in ICU Patients in Shanghai, China.
The study identified bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, and bla KPC-2 as the most prevalent resistance genes in K. pneumoniae isolates from ICU patients in Shanghai, China.
Genetic characterization of third- or fourth-generation cephalosporin-resistant avian pathogenic Escherichia coli isolated from broilers.
The study identified various beta-lactamase genes, including bla CTX-M-15, bla TEM-1, bla CTX-M-1, bla CTX-M-14, bla SHV-12, bla CTX-M-27, bla OXA-1, bla TEM-135, and bla CMY-2, in third- or fourth-generation cephalosporin-resistant avian pathogenic E. coli isolates from Korean broiler operations.
Pathogenomics analysis of high-risk clone ST147 multidrug-resistant Klebsiella pneumoniae isolated from a patient in Egypt.
The study identifies multiple AMR genes in the MDR-KP isolate WSF99, including various beta-lactamases, carbapenemase, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and others, highlighting the complex resistance profile of this high-risk clone.
Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics.
The study demonstrates that CRISPR interference (CRISPRi) can re-sensitize laboratory strains and clinical isolates to last-resort antibiotics by repressing the expression of specific antibiotic resistance genes (ARGs).
Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?
The study identified multiple antibiotic resistance genes in clinical Klebsiella pneumoniae isolates, including bla TEM, bla SHV, bla CTX-M, and bla OXA families, as well as aminoglycoside, fluoroquinolone, and sulfonamide resistance genes. Effluent isolates showed fewer resistance genes and lower resistance levels compared to clinical isolates.
Genomic characterization of two distinct Klebsiella pneumoniae strains in a fatal case of relapsed acute myelogenous leukemia: a case report.
The study identified two distinct Klebsiella pneumoniae strains, ST147 and ST967, with varying resistance profiles. ST147 isolates harbored multiple resistance genes including bla OXA−181, aadA, aadA5, bla CTX−M−15, bla OXA−1, bla SHV−11, bla TEM−1, sul1, qnrS1, and tet(A), while ST967 had a more limited resistome with aac(3)-IIa, bla SHV−27, and dfrA14.
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