blactx-m-8–240d

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Extended-spectrum beta-lactamase

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Protein entries specific to blactx-m-8–240d

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Validation StatusCandidate

Overview

Validation Method: molecular characterization via PCR and sequencing
Drug Classes: cephalosporins
Organisms: Escherichia coli, Klebsiella pneumoniae
Geographic Location: Brazil
Papers: 1
Databases: Reslit

Papers1

Activity of ceftolozane/tazobactam and comparators against gram-negative bacilli: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART - Brazil), 2018‒2021.

PMID 39667188 · 2025

The study identified several beta-lactamase genes, including bla KPC-2, bla CTX-M variants, and bla NDM-1, which confer resistance to carbapenems and cephalosporins in Gram-negative bacilli in Brazil. These genes were detected in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa isolates.

Gene Information

Gene Name: blactx-m-8–240d
Allele: blaCTX-M-8–240D
Encodes: Extended-spectrum beta-lactamase
Source Database: Reslit
Confers Resistance To: cephalosporins
Organisms Tested In: • Escherichia coli
• Klebsiella pneumoniae
Geographic Location: Brazil
Validation Method: molecular characterization via PCR and sequencing

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blactx-m-8–240d

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blactx-m-8–240d

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