blages−5

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Beta-lactamase

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to blages−5

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Validation StatusCandidate

Overview

Validation Method: experimental validation via WGS and PCR
Drug Classes: carbapenems
Organisms: Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens, Citrobacter freundii, Escherichia coli, Klebsiella oxytoca, Klebsiella michiganensis
Geographic Location: South Africa
Papers: 1
Databases: Reslit

Papers1

Carbonyl Cyanide m-Chlorophenylhydrazine (CCCP) Reverses Resistance to Colistin, but Not to Carbapenems and Tigecycline in Multidrug-Resistant Enterobacteriaceae.

PMID 28261184 · 2017

The study identified bla NDM−1 and bla GES−5 as carbapenem resistance genes in multidrug-resistant Enterobacteriaceae, and demonstrated that CCCP can reverse colistin resistance but not carbapenem or tigecycline resistance.

Gene Information

Gene Name: blages−5
Allele: blaGES−5
Encodes: Beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
• Enterobacter spp.
• Serratia marcescens
• Citrobacter freundii
• Escherichia coli
• Klebsiella oxytoca
• Klebsiella michiganensis
Geographic Location: South Africa
Validation Method: experimental validation via WGS and PCR
Sequence Accession: PRJNA287968

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blages−5

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blages−5

Gene Information