blal1a

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metallo-beta-lactamase

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UniProt

Protein entries specific to blal1a

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Validation StatusCandidate

Overview

Mechanism: hydrolyzes beta-lactam antibiotics
Validation Method: cell-based experiments with mutant variants
Drug Classes: ceftazidime, cefepime, imipenem, meropenem
Organisms: Stenotrophomonas maltophilia, Escherichia coli DH10B
Papers: 1
Databases: Reslit

Papers1

Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase.

PMID 36826989 · 2023

The study characterizes the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia, identifying key residues involved in conformational changes affecting the active site and catalytic activity. Mutations in these residues significantly impacted the enzyme's ability to hydrolyze beta-lactam antibiotics.

Gene Information

Gene Name: blal1a
Allele: blaL1a
Encodes: metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolyzes beta-lactam antibiotics
Confers Resistance To: ceftazidimecefepimeimipenemmeropenem
Organisms Tested In: • Stenotrophomonas maltophilia
• Escherichia coli DH10B
Validation Method: cell-based experiments with mutant variants

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blal1a

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blal1a

Gene Information