Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Beta-lactamase
Overview
Carbonyl Cyanide m-Chlorophenylhydrazine (CCCP) Reverses Resistance to Colistin, but Not to Carbapenems and Tigecycline in Multidrug-Resistant Enterobacteriaceae.
The study identified bla NDM−1 and bla GES−5 as carbapenem resistance genes in multidrug-resistant Enterobacteriaceae, and demonstrated that CCCP can reverse colistin resistance but not carbapenem or tigecycline resistance.
Genetic Configuration of Genomic Resistance Islands in Acinetobacter baumannii Clinical Isolates From Egypt.
The study identified a variety of AMR genes in Acinetobacter baumannii clinical isolates from Egypt, including novel variants such as blaADC-258 and resistance islands like RI-PER-7. Key findings include the prevalence of blaOXA-23, blaTEM-1, and armA, along with multiple resistance determinants associated with mobile genetic elements.
Antidepressants promote the spread of antibiotic resistance via horizontally conjugative gene transfer.
The study shows that antidepressants can promote the conjugative transfer of antibiotic resistance genes (ARGs) between different bacterial genera, highlighting the potential link between antidepressant use and the spread of antibiotic resistance.
Molecular eidemiology of carbapenem-resistant Enterobacter cloacae complex in a tertiary hospital in Shandong, China.
The study identified NDM-5 carbapenemase produced by ST171 and NDM-1 carbapenemase produced by ST418 as the leading causes of carbapenem resistance in Enterobacter cloacae complex strains in a tertiary hospital in Shandong, China. A novel ST (ST1965) was also detected, carrying the bla NDM−1 gene.
Molecular characterization of carbapenemase and extended spectrum beta-lactamase producing Acinetobacter baumannii isolates causing surgical site infections in Ethiopia.
The study identified several beta-lactamase genes, including bla CTX-M−15, bla CTX-M−65, bla TEM−1B, bla OXA−1, bla OXA−69, bla OXA−23, bla OXA−66, and bla NDM−1, which confer resistance to various beta-lactam antibiotics in Acinetobacter baumannii isolates causing surgical site infections in Ethiopia.
Detection of carbapenemases in Enterobacterales and other Gram-negative bacilli recovered from hospital and municipal wastewater in Mexico City.
The study identified several carbapenemase genes, including bla KPC, bla NDM, bla VIM−2, bla OXA−48, bla NDM−1, and bla NDM−5, in various Gram-negative bacteria from hospital and municipal wastewater in Mexico City.
Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics.
The study demonstrates that CRISPR interference (CRISPRi) can re-sensitize laboratory strains and clinical isolates to last-resort antibiotics by repressing the expression of specific antibiotic resistance genes (ARGs).
Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?
The study identified multiple antibiotic resistance genes in clinical Klebsiella pneumoniae isolates, including bla TEM, bla SHV, bla CTX-M, and bla OXA families, as well as aminoglycoside, fluoroquinolone, and sulfonamide resistance genes. Effluent isolates showed fewer resistance genes and lower resistance levels compared to clinical isolates.
Carbapenem-resistant Klebsiella pneumoniae gut colonization and subsequent infection in pediatric intensive care units in shanghai, China.
The study identified bla KPC−2, bla NDM−1, and bla NDM−5 as the most prevalent carbapenemase genes in CRKP isolates from anal swabs and infection specimens in pediatric ICU patients. ST11 was the most common sequence type, and bla KPC−2 was significantly more frequent in infection isolates.
Cefiderocol-resistant pathogens in German hospital wastewater: a reservoir for multidrug resistance.
The study identifies multiple AMR genes, including bla NDM−1, bla VIM−1, bla OXA−48, and bla KPC−2, in cefiderocol-resistant isolates from German hospital wastewater, highlighting the presence of multidrug-resistant pathogens with diverse resistance mechanisms.
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